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Multicellular Living Organisms And Unmodified Parts Thereof And Related Processes > Nonhuman Animal > Transgenic Nonhuman Animal (e.g., Mollusks, Etc.) > Mammal MammalMammal patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.11/15/07 - 20070266451 - Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (eclph) gene The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of ... 11/01/07 - 20070256148 - Dep2 and its uses in major depressive disorder and other related disorders The present invention relates to DEP2 and its uses in connection with major depression or related disorders. ... 10/25/07 - 20070250941 - Vegf receptor conditional knockout animals and methods of use Transgenic non-human animals and methods of producing non-human transgenic animals comprising within their genome a conditional targeted mutation in a VEGFR, e.g., VEGFR1 or VEGFR2, gene are provided along with methods and vectors used to produce such animals or cells. ... 10/11/07 - 20070240235 - Methods for supporting and producing human cells and tissues in non-human mammal hosts Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animal-hosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, ... 10/04/07 - 20070234437 - Detection of lethality gene for improved fertility in mammals Oligonucleic acid molecules comprising a SNP site at a position corresponding to position 7480 of the bovine signal transducer and activator of transcription (STAT5A) coding sequence (SEQ ID NO: 1). Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for ... 09/27/07 - 20070226815 - Interferon-alpha induced gene The present invention relates to identification of a gene upregulated by interferon-a administration corresponding to the cDNA sequence set forth in SEQ. ID. NO. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-α and other interferons which act at ... 09/20/07 - 20070220620 - Tat-046 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-046 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-046 is associated with abnormal development and growth, and may be useful as a ... 09/20/07 - 20070220619 - Methods for testing for caloric restriction (cr) mimetics Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the transgenic animal includes an added gene from another type of animal ... 09/06/07 - 20070209083 - Cell and transgenic animal modelling human antigenic presentation and their uses The invention concerns an isolated animal cell comprising at least a transgene including at least a nucleotide sequence coding for at least a human polypeptide involved in the recognition and/or antigenic activation by T cells. The invention is characterised in that said cell, or a progeny of said cell, expresses ... 09/06/07 - 20070209082 - Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby Methods and compositions for enhancing taxane sensitivity are provided. Aspects of the subject methods include administering to a subject a txr1 pathway modulatory agent in conjunction with a taxane. Also provided are txr1 polypeptides and nucleic acids encoding the same. The subject methods and compositions find use in a variety ... 08/30/07 - 20070204353 - Transgenic animals and methods of monitoring hedgehog responding cells Transgenic non-human animal models are described that allow for the fate mapping and identification of cells that respond to hedgehog signaling in vivo during a particular time period. More particularly, these animal models and cells obtained from these animal models may be used to screen for agonists or antagonists of ... 08/23/07 - 20070199081 - Variants of the gamma chain of ampx, dna sequences encoding the same, and uses thereof Variants of the gamma chain of vertebrate AMP-activated kinase (AMPK), as well as nucleic acid sequences encoding the variants and use thereof for the diagnosis or treatment of dysfunction of energy metabolisms. ... 08/16/07 - 20070192887 - Tat-042 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-042 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-042 is associated with abnormal development and growth, and may be useful as a ... 08/16/07 - 20070192886 - Tat-044 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-044 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-044 is associated with abnormal development and growth, and may be useful as a ... 08/16/07 - 20070192885 - Tat-039 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-039 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-039 is associated with abnormal development and growth, and may be useful as a ... 08/16/07 - 20070192884 - Tat-038 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-038 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-038 is associated with abnormal development and growth, and may be useful as a ... 08/16/07 - 20070192883 - Tat-028 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-028 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-028 is associated with abnormal development and growth, and may be useful as a ... 08/16/07 - 20070192882 - Hereditary angioedema type iii The present invention relates to a method of diagnosing hereditary angioedema type III (HAE III) or a predisposition thereto in a subject being suspected of having developed or of having a predisposition to develop a hereditary angioedema type III or in a subject being suspected of being a carrier for ... 08/16/07 - 20070192881 - Culture conditions and growth factors affecting fate determination, self-renewal and expansion of rat spermatogonial stem cells The present invention relates to methods of identifying and enriching rat spermatogonioal stem cells, and compositions thereof. Further, the invention relates to methods and compositions for the isolation, maintenance and proliferation of rat spermatogonial stem cells, as well as methods and compositions for the identification and use of factors influencing ... 08/16/07 - 20070192880 - Horming response element binding transregulators Disclosed are compositions and methods for ERE-binding tansregulators that specifically and potently regulate ERE-containing genes. To accomplish this, we took advantage of the modular nature of ER and initially designed a monomeric ERE binding module by co-joining two DNA binding domains with the hinge domain. Integradon of strong activation or ... 08/09/07 - 20070186296 - Cloning, characterization, and application of tnfrsf19 in neurological disorders TNFRSF19 nucleic acids and proteins, TNFRSF19 binding partners and modulators, and methods of using the same. ... 08/09/07 - 20070186295 - Tat-036 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-036 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-036 is associated with abnormal development and growth, and may be useful as a ... 08/09/07 - 20070186294 - Tat-030 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-030 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-030 is associated with abnormal development and growth, and may be useful as a ... 08/09/07 - 20070186293 - Rat embryonic stem cell The present invention provides a rat embryonic stem cell characterized by having the following properties of (a) expressing Oct3/4 gene and Nanog gene, (b) positive for alkaline phosphatase activity, (c) having an embryoid body forming ability, (d) expressing SSEA (Stage-Specific Embryonic Antigen)-1 and SSEA-4, (e) having the same number of ... 08/09/07 - 20070186292 - Methods for genetic diversification in gene conversion active cells The invention relates to a modified lymphoid cell having gene conversion fully or partially replaced by hypermutation, wherein said cell has no deleterious mutations in genes encoding paralogues and analogues of the RAD51 protein, and wherein said cell is capable of directed and selective genetic diversification of a target nucleic ... 08/02/07 - 20070180545 - Tat-031 and methods of assessing and treating cancer Surprisingly, the present inventors have discovered that expression of TAT-031 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-031 is associated with abnormal development and growth, and may be useful as a ... 08/02/07 - 20070180544 - Methods and compositions for autism spectrum disorders Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the endoplasmic reticulum (ER) to reverse incorrect disulfide binding of the protein neuroligin. Also ... 08/02/07 - 20070180543 - Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties The present invention provides methods and compositions for drug screens to identify and characterize agents that are agonistic or antagonistic to activation of the promoter region of the NAG-1 gone. Activation of the NAG-1 gene is associated with the apoptotic elimination of cancer cells both in vitro and in vivo. ... 08/02/07 - 20070180542 - Culture conditions and growth factors affecting fate determination, self-renewal and expansion of rat spermatogonial stem cells The present invention relates to methods of identifying and enriching spermatogonioal stem cells, and compositions thereof. Further, the invention relates to methods and compositions for the isolation, maintenance and proliferation of spermatogonial stem cells, as well as methods and compositions for the identification and use of factors influencing spermatogonial stem ... 07/26/07 - 20070174923 - Targeting of sall4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (mds) The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are disclosed which demonstrate that constitutive expression of SALL4 increases leukemogenic potential in cells of model animal systems. Moreover, constitutive expression of select isoforms (e.g., SALL4B) ... 07/26/07 - 20070174922 - Nucleic acid encoding novel type-1 cytokine receptor glm-r The present invention is directed to novel polypeptides having sequence similarity to Interleukin 6 receptor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide ... 07/19/07 - 20070169211 - Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof The invention features non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof. ... 07/19/07 - 20070169210 - Methods and compositions for modulating gamete adhesion Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one discoidin/C domain, and optionally at least one EGF domain. A representative polypeptide includes, but is not limited to SED1 polypeptides (SEQ ID NO. 2-7), ... 07/12/07 - 20070162987 - Leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissue mass. ... 07/12/07 - 20070162986 - Anf analogue A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin ... 07/12/07 - 20070162985 - Diabetes-mediating proteins and therapeutic uses thereof Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating proteins, and methods of preventing or ameliorating diabetes by administering a compound capable of altering the expression ... 07/12/07 - 20070162984 - Stars-a muscle-specific actin-binding protein The present invention relates to a new polypeptide and the gene coding therefore, gene being an evolutionarily conserved actin-binding protein, called STARS (striated muscle activator of Rho signalin), that is expressed specifically in cardiac and skeletal muscle cells and is upregulated in response to calcineurin signaling during cardiac hypertrophy. STARS ... 07/05/07 - 20070157327 - Parkin interacting polypeptides and methods of use The invention provides parkin binding polypeptides and encoding nucleic acids. The invention also provides antibodies specific for the parkin binding polypeptides. The invention additionally provides methods of detecting a parkin binding polypeptide and detecting a nucleic acid encoding a parkin binding polypeptide. The invention further provides methods of using a ... 07/05/07 - 20070157326 - Ee3-protein family and corresponding dna sequence The present invention relates to (i) DNA sequences, (ii) expression vectors comprising DNA sequences of the invention, (iv) host cells having the expression vectors of the invention, (v) gene products encoded by sequences of the invention, (vi) transgenic animals altered with respect to sequences of the invention, (vii) antibodies directed ... 06/28/07 - 20070150972 - Method for detecting nipah virus and method for providing immunoprotection against henipa viruses The present invention provides an animal model for monitoring Nipah virus infection, a method for the quantitative detection and rapid characterization of Nipah virus RNA in a sample, a composition which can be used to provide immunoprotection in an individual as well as monoclonal antibodies which neutralize Nipah and Hendra ... 06/28/07 - 20070150971 - Sequences upstream of the carp gene, vectors containing them and uses thereof The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells. The ... 06/21/07 - 20070143868 - Sperm cell processing and preservation systems Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, ... 06/21/07 - 20070143867 - Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In ... 06/21/07 - 20070143866 - Human photoaged skin model The method of producing the human photoaged skin model is characterized in that a transplanted skin area of an immunodeficient non-human animal which has undergone transplantation of human skin is irradiated with UV-B light of 80-100 mJ/cm2 for consecutive 4 to 8 weeks, and the irradiated area is left to ... 06/14/07 - 20070136830 - Transgenic rats and spermatogonial stem cells A transgenic rat expresses a gene of interest, such as EGFP, exclusively in the germ cells of both males and females. From such a transgenic rat one can isolate a line of spermatogonial stem cells, which can renew and proliferate in culture. ... 06/14/07 - 20070136829 - Novel type-1 cytokine receptor glm-r The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, ... 06/14/07 - 20070136828 - Methods of using molecules related to organic cation transporter 3 (oct3) for treating depression, anxiety neuroses, drug dependencies, and other similar mental disorders Mice in which OCT3 expression is suppressed were successfully constructed by administering antisense against OCT3 gene into the brain. Mice in which OCT3 expression is suppressed display phenotypes related to mental disorders such as anti-depression and anti-anxiety, and therefore the mice can be applied to the screening of therapeutic agents ... 06/14/07 - 20070136827 - Cis/trans riboregulators The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA ... 06/07/07 - 20070130629 - Renal regulatory elements and methods of use thereof Disclosed are cis-acting regulatory elements from a KIM-1 gene. The elements can be used to direct the expression of operably linked sequences in renal tissue. ... 05/17/07 - 20070113296 - Novel brain-localized protein kinases homologous to homeodomain-interacting protein kinases The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression ... 05/10/07 - 20070107073 - Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome The present invention discloses proteins secreted by the developing pancreas, and polynucleotides, which identify and encode these proteins. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes), obesity, and/or metabolic syndrome. ... 05/10/07 - 20070107072 - Transgenic amphibian models for lymphatic vessel development The present invention provides molecular tools for the visualization of the lymphatic vessel system in amphibian. Furthermore, the invention provides assays that allow screening for compounds able to modulate lymphangiogenesis. ... 05/10/07 - 20070107071 - Use of regulatory sequences for specific, transient expression in neuronal determined cells The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the ... 05/03/07 - 20070101450 - High-affinity choline transporter The present invention provides a protein having high-affinity choline transporter activity which is important physiologically, a gene encoding the protein, and a method of screening a material promoting the high-affinity choline transporter activity with the use of the same, and the like. By examining high-affinity choline uptake activity of Na+-dependent ... 04/26/07 - 20070094743 - Abcg1/abcg4-related methods and compositions This invention provides a non-macrophage cell having therein an expression vector encoding ABCG1, wherein the non-macrophage cell expresses ABCG1. This invention further provides a non-macrophage cell having therein an expression vector encoding ABCG4, wherein the non-macrophage cell expresses ABCG4. This invention further provides related transgenic animals and methods. ... 04/19/07 - 20070089177 - Transgenic animal and methods for decreasing cardiac cell death via cardiac-specific sir2alpha overexpression The present invention relates to a transgenic animal and methods for increasing the expression or activity of Sir2α protein. An increase in the expression of Sir2α protein prevents stress- and age-related cardiac cell death thereby facilitating the treatment of cardiac diseases or conditions associated with aging. ... 04/19/07 - 20070089176 - Cytokine involved in epithelial-mesenchymal transition The functional characterization of ILEI to be a novel cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD. ... 04/12/07 - 20070083941 - Rat trpm7 polynucleotide and encoded protein This invention relates to isolated nucleic acid and amino acid sequences of rat TRPM7 gene, expression cassettes nucleic acid sequences of rat TRPM7 gene, recombinant host cells comprising nucleic acid and amino acid sequences of rat TRPM7 gene, and methods of screening for modulators of the TRPM7 gene and protein. ... 04/05/07 - 20070079392 - Human g protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the ... 03/29/07 - 20070074298 - Versican and epithelial-mesenchymal interaction The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability. ... 03/29/07 - 20070074297 - Taar1 knock out animal The present invention relates to a vector construct comprising genomic sequences homologous to upstream and downstream regions flanking the single coding exon of the TAAR1 gene, one or more selection marker genes and optionally a reporter gene and the use thereof. The present invention further provides TAAR1 knock-out animals and ... 03/29/07 - 20070074296 - Rtd receptor Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided. ... 03/22/07 - 20070067858 - Novel il-8-like polypeptides The present invention discloses open reading frames (ORFs) in human genome encoding for novel IL-8-like/TMEM9 polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical ... 03/15/07 - 20070061906 - Human t2r75 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R75 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070061905 - Human t2r51 taste receptor and related assays for identifying bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R51 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070061904 - Human t2r65 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R64 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070061903 - Human t2r54 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R54 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070061902 - Human t2r64 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R64 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/08/07 - 20070056052 - Methods of generating knock-out rodents A method for generating knock-out rodents including rats and mice is disclosed. The method involves mutagenizing a rodent with a mutagen, obtaining progeny of the mutagenized rodent, and identifying, among the progeny, one progeny that carries a loss-of-function modification of a target gene. The preferred mutagen for generating knock-out mice ... 03/01/07 - 20070050857 - Method of treatment and prophylaxis The present invention relates generally to a method for the treatment and/or prophylaxis of a disease condition, agents useful in such treatments and an animal model useful in screening and evaluating potentially efficacious therapeutic agents. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of a ... 03/01/07 - 20070050856 - Use of protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome The present invention discloses proteins expressed by the developing pancreas, and polynucleotides, which identify and encode these proteins. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes), obesity, and/or metabolic syndrome. ... 02/22/07 - 20070044164 - Methods for producing micrornas The invention relates to recombinant vectors for inducible and/or tissue specific expression of double-stranded RNA molecules that interfere with the expression of a target gene. In certain embodiments, the invention relates to the use of Tet (tetracycline)-responsive RNA Polymerase II (Pol II) promoters (e.g., TetON or TetOFF) to direct inducible ... 02/22/07 - 20070044163 - Interferon gamma-like protein This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of disease. ... 02/22/07 - 20070044162 - Transgenic rat as animal model for human huntingdon's disease Huntington's Disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disease from the group of CAG repeat/polyglutamine diseases and is characterized by a triad of psychiatric alterations, dementia and motor dysfunction. On a sub-cellular level, a mutation with extended CAG tri-nucleotide repeats has been identified as the cause of HD. The ... 02/08/07 - 20070033665 - Unactivated oocytes as cytoplast recipients for nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a ... 02/08/07 - 20070033664 - Quiescent cell populations for nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer ... 02/01/07 - 20070028313 - Quiescent cell populations for nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer ... 02/01/07 - 20070028312 - Unactivated oocytes as cytoplast recipients for nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a ... 01/25/07 - 20070022484 - Probes for analyzing interaction between proteins and method of analyzing interaction between proteins using the same The present invention provides a pair of probes for analyzing protein-protein interactions, which comprises a probe A containing at least an N-terminal half polypeptide of split Renilla luciferase, and a probe B containing at least the remaining C-terminal half polypeptide of split Renilla luciferase. ... 01/18/07 - 20070016970 - Guinea pig-chymase The present invention relates to the sequence of guinea pig chymase. Since guinea pigs express only one chymase isoform, they are particularly suitable as a model for a method for identifying compounds that modulate chymase. ... 01/18/07 - 20070016969 - Expression vector for hirudin and transformed cells and transgenic animals containing said vector The present invention relates to a nucleic acid construct encoding hirudin and a transgenic mammal whose genome comprises the nucleic acid construct as well as a process for producing hirudin from the transgenic mammal. ... 01/18/07 - 20070016968 - Treatment of pain through expression of opioid receptors Disclosed are compositions and methods related to nucleic acid constructs containing a HUMOR encoding element. These constructs can be used in the treatment of pain. ... 01/18/07 - 20070016967 - Novel ifngamma-like polypeptides The present invention discloses novel open reading frames (ORFs) in human genome encoding for ORFs characterized for polypeptides having at least one activity in human Interferon gamma, and reagents related thereto including variants and fragments of said polypeptides, as well as the encoding nucleic acids and ligands directed against them. ... 01/11/07 - 20070011757 - Transgenic rodents as animal models for modulation of b1 bradykinin receptor protein Transgenic rats are generated which incorporate a primate B1 bradykinin receptor transgene(s) into their genome. This B1 bradykinin receptor gene is expressed in these transgenic rats, which results in binding of compounds which are selective for the primate form (such as the human form) of the receptor and not the ... 01/11/07 - 20070011756 - Method of constructing offspring originating from frozen sperm stem cell The present invention provides a method of producing offspring originating in a spermatogonial stem cell of a donor animal which comprises generating spermatozoa in the reproductive organ of a male recipient animal with the use of frozen spermatogonial stem cells originating in the donor animal to give a male individual ... 01/11/07 - 20070011755 - Diabetes type 2 animal model A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipfl/Pdx 1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the ... 01/04/07 - 20070006332 - Methods for enhancing embryo viability The present invention provides a method for enhancing embryo viability comprising administering at least one inhibitor of p53 or a p53-associated pathway to one or more of the following: the embryo, oocytes, sperm, a femme animal or a male animal. ... 12/28/06 - 20060294608 - Novel haemopoietin receptor and genetic sequences encoding same The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and ... 12/28/06 - 20060294607 - Human podocalyxin alternative-spliced forms and uses thereof The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents ... 12/28/06 - 20060294606 - Tn5 transposase-mediated transgenesis The present invention relates to methods for obtaining transgenic embryos, animals, and plants. Also encompassed in the present invention are transposase-mediated trangenesis methods including transposase-mediated intracytoplasmic sperm injection (TN:ICSI), transposase-mediated intracytoplasmic round spermatid injection (TN:ROSI), and transposase-mediated in vitro fertilization (TN:IVF). ... 12/28/06 - 20060294605 - Novel human dickkopf-related protein and nucleic acid molecules and uses therefor Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule ... 12/28/06 - 20060294604 - Model for studying the role of genes in tumor resistance to chemotherapy The invention provides the components of in vivo and in vitro systems and methods which use them to study the effects of altered expression of a gene activity, such as the human akt, bcl-2, eIF4E or PTEN activities, on the descendants of stem cells that have been engineered to give ... 12/28/06 - 20060294603 - Cloning of transgenic animals comprising artificial chromosomes The invention is directed in part to totipotent cells that have one or more artificial chromosomes; processes for producing such cells; processes for using such cells (e.g., nuclear transfer); transgenic embryos and transgenic animals cloned from such cells; and processes for producing such embryos and animals. ... 12/21/06 - 20060288433 - Selecting animals for parentally imprinted traits The present invention relates to a method for selecting a domestic animal having desired genotypic properties comprising testing the animal for the presence of a parentally imprinted quantitative trait locus (QTL). The invention further relates to the use of an isolated and/or recombinant nucleic acid comprising a QTL or functional ... 12/21/06 - 20060288432 - Identification of a jak2 mutation in polycythemia vera The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative ... 12/14/06 - 20060282909 - Methods and compositions for therapeutic intervention in cardiac hypertrophy The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca++ stimulation of the hypertrophic response is mediated through NF-AT3. Thus, the present invention provides methods of treating cardiac hypertrophy as ... 12/14/06 - 20060282908 - Identification of the genetic determinants of the polymorphic cyp3a5 expression The present invention relates to a polymorphic CYP3A5 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or ... 12/14/06 - 20060282907 - Transgenic animal having fatty acid desaturase and method of producing the same To provide meat that is beneficial to human health, for the purpose to produce transgenic animals in which the content of unsaturated fatty acids increase is increased, transgenic animals characterized by increased content of unsaturated fatty acids that are beneficial to human health is provided by the present invention. Furthermore, ... 12/07/06 - 20060277617 - Nucleic acid construct, metabolic disordered non-human animal and use thereof The present invention provides a transgenic non-human animal comprising a human-derived LXRα mutant gene to express a human LXRα mutant protein, wherein the human LXRα mutant is an isoform of LXRα involved in inhibition of normal cholesterol metabolism by normal LXRα; a nucleic acid construct which can be used to ... 12/07/06 - 20060277616 - Method for cloning of the rat by nuclear transfer The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the production of molecules of interest or as study models. ... 12/07/06 - 20060277615 - Method of determining xenograft responses The present invention provides a method of modifying or engineering cells that are intended for introduction into a host as a xenograft, the modification or engineering of the cells comprising inclusion of at least one suitable reporter system. Inclusion of a reporter system permits monitoring of the xenograft and determination ... 12/07/06 - 20060277614 - Mammal prolactin variants The invention relates to mammal prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids thereby preventing the formation of a disulfide bridge between Cys4 and Cys11 and, a sterically hindering mutation or set of mutations within binding site 2 of PRL. These variants ... 11/23/06 - 20060265767 - Compositions and methods for treatment of autoimmune and related diseases Compositions and methods are provided for treatment of autoimmune and other related diseases. 3d, a point mutation of the protein uncoordinated-93b (unc-93B), unc-93A, unc-93B, and unc-93C, polypeptides, nucleic acids encoding them and methods for making and using them, for example, to produce transgenic non-human animals. ... 11/16/06 - 20060259992 - Animal models of long qt syndrome and uses thereof Provided are animal models of long QT syndrome (LQTS). The animal models are useful, for example, in screening of drugs for adverse effects in subjects with LQTS, in screening candidate therapeutics for the treatment or prevention of LQTS, and in determining gene expression in LQTS. ... 11/09/06 - 20060253913 - Production of hsa-linked butyrylcholinesterases in transgenic mammals The present invention provides methods for the large-scale production of recombinant butyrylcholinesterase fused to human serum albumin in cell culture, and in the milk and/or urine of transgenic mammals. The recombinant butyrylcholinesterase-albumin fusion protein of this invention can be used to treat and/or prevent organophosphate pesticide poisoning, nerve gas poisoning, ... 11/02/06 - 20060248606 - Mouse model for hepatitis c A rodent model for HCV infection is obtained by introducing into rodents which harbor a liver-specific defect an expression system which comprises an HCV replicon or a reverse transcript thereof and at least a nucleotide sequence encoding a rescue protein which remedies the defect. ... 10/26/06 - 20060242721 - Gene families associated with liver cancer The invention relates generally to the changes in gene expression in hepatocellular carcinoma. The invention relates specifically to human genes that correspond to mRNA species that are differentially expressed in cancerous liver tissue and in cancerous neoplasms compared to non-cancerous liver tissue. ... 10/19/06 - 20060236415 - Neural crest cells specific promoters; isolated neural crest cells; and methods of isolating and of using same A vector comprising a promoter sequence driving the coding sequence of a visual marker protein, wherein the promoter sequence functions specifically in neural crest cells and methods for using same. ... 10/19/06 - 20060236414 - Proteases and methods for producing them A secreted mature polypeptide derived from an S2A or S1E protease which after maturation has protease activity, which polypeptide when expressed and before maturation comprises a heterologous pro-region. ... 10/19/06 - 20060236413 - Transposon-based targeting system The present invention relates to a targeting system comprising, preferably as distinct components, (a) a transposon which is devoid of a polynucleotide encoding a functional transposase comprising a polynucleotide of interst; and (ba) a fusion protein comprising (i) a domain specifically binding to a transposase or a fragment or derivative ... 10/19/06 - 20060236412 - Porcine uroplakin ii promoter and the production method of useful proteins using said promoter The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the present invention promotes the bladder-specific expression of a target protein at high efficiency. An animal, which was transformed using ... 10/19/06 - 20060236411 - Antagonists il-15 The invention relates to fusion proteins consisting of a wild-type IL-15 and a IgG-Fc fragment, apart from a mouse IgG2b fragment, nucleic acids encoding said proteins, vectors, modified cells, and also to the use thereof for preparing drugs which are used, for example for preventing and/or curing disorders resulting from ... 09/28/06 - 20060218653 - Novel molecular variant and uses thereof The present invention relates to CLN5 nucleic acid and protein variants and functional derivatives, homologues and analogues thereof, together with cellular expression systems, and uses for same. The present invention also provides genetically modified mammalian animals and methods of use thereof. More particularly, the present invention relates to mammalian animals ... 09/21/06 - 20060212951 - Site-specific recombination in eukaryotes and constructs useful therefor Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline would simplify current protocols for producing mice bearing homologously recombined alleles that have been secondarily rearranged by ... 09/21/06 - 20060212950 - Inducible small rna expression constructs for targeted gene silencing The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals. ... 09/14/06 - 20060206949 - Custom-made meganuclease and use thereof New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal, or plant comprising said polynucleotide sequences, process for producing said rare-cutting endonucleases and any use thereof, more particularly, for genetic engineering, antiviral therapy and gene therapy. ... 09/07/06 - 20060200870 - Methods of treating muscular dystrophy The invention provides methods of preventing, treating and ameliorating symptoms of muscular dystrophy. The invention also provides experimental systems for identifying and evaluating such treatments. ... 09/07/06 - 20060200869 - Lentiviral vectors carrying synthetic bi-directional promoters and uses thereof It is described a bidirectional promoter for expression of at least two coding sequences in opposite direction in animal cells; bidirectional expression cassettes; expression constructs; gene transfer expression vectors, and methods for the use thereof. ... 08/31/06 - 20060195918 - Embryonic stem cell self maintenance and renewal reporter The present invention relates to methods and compositions for assaying embryonic stem cell maintenance. In particular, the present invention provides reporter constructs for stem cell pluripotency and differentiation and cells and organisms containing such constructs. ... 08/24/06 - 20060191029 - Method and system for fusion and activation following nuclear transfer in reconstructed embryos The present invention provides data to demonstrate that the re-fusion, of a mammalian karyoplast to an enucleated in vivo ovulated oocyte, following an unsuccessful initial simultaneous electrical fusion and activation event offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production ... 08/24/06 - 20060191028 - Developmental animal model of temporal lobe epilepsy Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the ... 08/17/06 - 20060185027 - Systems and methods for identifying mirna targets and for altering mirna and target expression The present invention generally relates to microRNAs such as vertebrate microRNA (miRNA), for example, mammalian miRNA. Various aspects of the invention are directed to the detection, production, or expression of miRNA. In one aspect, the invention provides systems and methods for identifying targets of miRNA sequences. For instance, in one ... 08/10/06 - 20060179500 - Methods and vectors for improving nucleic acid expression The invention features methods of making transgenic animals, and transgenic animals made by such methods. The method includes introducing into a cell, a nucleic acid construct comprising a nucleic acid sequence encoding a heterologous polypeptide under the control of a mammary epithelial cell promoter, an insulator positioned 5′ from the ... 08/10/06 - 20060179499 - Non-human animal models for diabetic complications and their uses The instant invention relates to methods for generating a non-human animal model for a diabetic complication. The invention further relates to screening methods for therapeutics of diabetic complications using the animal model generated by the methods of the invention. ... 08/10/06 - 20060179498 - Reverse breeding A method for efficiently producing homozygous organisms from a heterozygous non-human starting organism, comprising providing of a heterozygous starting organism; allowing the starting organism to produce haploid cells; creating homozygous organisms from the haploid cells thus obtained; and selecting the organisms having the desired set of chromosomes, wherein during production ... 08/03/06 - 20060174359 - Method for selecting cell lines to be used for nuclear transfer in mammalian species The present invention provides data to demonstrate that the fusion performance of a cell-line in procedures involving fusion and cleavage indices either alone or in combination are a means for selecting a cell lines that will be successful in a nuclear transfer or microinjection program. This technique and method of ... 08/03/06 - 20060174358 - Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells An improved method of nuclear transfer employing long-term cultured somatic cells as the donor cells and enucleated oocytes as the recipient cells to produce dividing cybrids. Such cybrids are useful for developing viable animals clones when nurtured in a suitable host environment. ... 07/27/06 - 20060168673 - Transgenic animals as models for neurodegenerative disease The present invention relates to cell and animal models for a disease condition and in particular to an animal model which can function as a model for neurodegenerative diseases, such as Alzheimers. ... 07/27/06 - 20060168672 - B7-like molecules and uses thereof Novel B7-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing B7-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with B7-like polypeptides. ... 07/27/06 - 20060168671 - Injection of caprine sperm factor (csf), phospholipase c zeta (plczeta) and adenophostin a as alternative methods of activation during nuclear transfer in the caprine species It has been found that caprine sperm factor, alone or in combination with adenophostin A, produces the Ca2+ oscillations characteristic of egg activation seen with fertilization. The introduction of caprine sperm factor and adenophostin A to eggs to produce reconstructed embryos has been optimized. ... 07/13/06 - 20060156424 - Quiescent cell populations for nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer ... 06/22/06 - 20060137029 - Novel g protein-coupled receptor encoding gene and diagnostic uses therefor The present invention provides GPR56 genes and polypeptides encoded therefor. The GPR56 genes of the invention are expressed highly in malignant tissues and the invention also provides diagnostic processes for detecting cancer or malignant tumors in human subjects The diagnostic and prognostic test of the present invention is particularly useful ... 06/15/06 - 20060130163 - Method of performing trangenesis The invention provides a method for generating transgenic animals and cells by the coinsertion of nucleic acid and a nucleus into an unfertilized oocyte. Preferably, the coinsertion is by microinjection and more preferably by piezo-electrically actuated microinjection. Transgene (tg) expressing embryos are here produced following coinjection of unfertilized mouse oocytes ... 06/08/06 - 20060123502 - Assay methods for identifying re2-like antagonists, methods of use, and non-human transgenic animals Provided is a human RE2-L protein, as well as the encoding nucleic acid, methods for screening for agents capable of modulating RE2-L related activity and treating RE2-L-mediated conditions. Further provided are animal models useful for screening agents capable of ameliorating or reducing anxiety related disorders and obsessive-compulsive disorders. ... 06/08/06 - 20060123501 - Method for treating inflammatory disorders The invention features a method of treating an inflammatory disorder, such as sepsis, in a subject. The method involves administering to the subject an antagonist of cIAP2 expression and/or function, so that the disorder is treated. ... 06/08/06 - 20060123500 - Methods of prescreening cells for nuclear transfer procedures The present invention provides for the production of transgenic animals through pre-screening methods designed to improve the efficiency of nuclear transfer and consequentially the production characteristics of transgenic mammals relative to proteins of interest. The invention is thus useful in the production of transgenic ungulate animals capable of producing desired ... 06/08/06 - 20060123499 - Civet animal model system for severe acute respiratory syndrome (sars) coronavirus infection and uses thereof The present invention is directed towards the use of the masked palm civet Paguma larvata (“civet”) as an animal model system for SARS, and is based on the novel demonstration of the present invention that civets may be infected with exogenous coronavirus, and that such infection produces SARS-like symptoms in ... 06/08/06 - 20060123498 - Paks as modifiers of the chk pathway and methods of use Human PAK genes are identified as modulators of the CHK pathway, and thus are therapeutic targets for disorders associated with defective CHK function. Methods for identifying modulators of CHK, comprising screening for agents that modulate the activity of PAK are provided. ... 06/08/06 - 20060123497 - Sperm-specific cation channel, catsper-4, and uses therefor Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods ... 06/08/06 - 20060123496 - Animal models A transgenic non-human animal whose genome comprises a polynucleotide encoding human ICAM-1 domains D1 and D2 and preferably encoding human ICAM-1 domains D1 and D2 and host non-human ICAM-1 domains D3, D4 and D5. Methods for the production of such transgenic animals, screening methods using such transgenic animals, associated transgenes, ... 06/08/06 - 20060123495 - Knockout mice and their use Non-human mammals and their progenies comprising an integrin alpha10 gene, integrin alpha11 gene, or both genes are provided, wherein at least a part of the integrin alpha10 gene, the integrin alpha11 gene, or both genes, of said non-human mammal and its progeny has/have been replaced with a DNA sequence comprising ... 06/01/06 - 20060117398 - Suppression of endogenous immunoglobulin expression The invention provides a novel approach for the suppression of endogenous antibody expression in non-human transgenic animals genetically engineered to express one or several human or humanized immunoglobulin transloci. Endogenous immunoglobulin expression in transgenic non-human animals is suppressed by selective expression of a suicide gene like a toxin only in ... 05/18/06 - 20060107336 - Nonbacterial prostatitis model animal The present invention provides an animal model for use in the development of a preventive or therapeutic agent for human chronic nonbacterial prostatitis, in particular a nonbacterial prostatitis nonhuman animal model mimicking the pathology of human chronic nonbacterial prostatitis. The nonbacterial prostatitis animal model is prepared by injecting hydrochloric acid ... 04/13/06 - 20060080745 - Gene reactivation by somatic hypermutation The invention provides an inactivated or attenuated gene functionally linked to a hotspot for somatic hypermutation. Inventive nucleic acids include inactivated genes operatively linked to immunoglobulin gene control elements. Embodiments of the invention include murine models of plasma cell disease and germinal center cell lymphoma. ... 03/30/06 - 20060070134 - Diagnosis and treatment of fanconi's anemia The novel FLJ11011 gene encoding a human ubiquitin-conjugating (E2) enzyme as well as gene fragments, coding sequences, mRNA variants and encoded proteins are disclosed. Additionally, methods of diagnosing and treating a patient that has or is suspected of having Fanconi's anemia or increased susceptibility to cancer or diminished capability of ... 03/30/06 - 20060070133 - Methods and compositions for importing nucleic acids into cell nuclei The present invention relates to methods and compositions for importing DNA into the nuclei of a specific cell type. In particular, the present invention provides methods and compositions for specifically targeting the nuclei of pulmonary cells. ... 03/23/06 - 20060064765 - Obesity gene The invention describes a previously unknown gene, termed 5′OT-EST, which is responsible for inducing an obesity and/or infertility phenotype in transgenic animals, and transgenic animals comprising mutants of 5′OT-EST which are useful for assaying compounds for the treatment of obesity and/or infertility. ... 03/23/06 - 20060064764 - Increasing gamete production with a gene switch A method of enhancing the production of gametes in a transgenic non-human animal is carried out by: (a) providing a transgenic non-human animal comprising cells that contain: (i) a response element; (ii) a nucleic acid encoding FSHβ operatively associated with said response element; (iii) an FSHβ promoter; (iv) an FSHβ ... 03/16/06 - 20060059577 - Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies are heart failure, and in particular diluted cardiomyopathy. ... 03/09/06 - 20060053502 - Systems and methods for protein production The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest ... 02/09/06 - 20060031952 - Methods for producing transgenic animals The invention provides methods for producing transgenic embryos and animals with a higher efficiency than presently available procedures based on Intracytoplasmic Sperm Injection (ICSI) of nucleic acid complexed with recombinase. ... 02/09/06 - 20060031951 - Improved modalities for the treatment of degenerative diseases of the retina This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. ... 02/02/06 - 20060026701 - Human albumin animal models for drug evaluation, toxicology and immunogenicity studies An animal model is provided which is genetically engineered to express human serum albumin, and such animals may be advantageously used in assessing drugs, vaccines or other therapeutic compounds that may be used in humans. In addition, an animal model is provided which does not manufacture its own albumin and ... 02/02/06 - 20060026700 - Tissue specific genes and gene clusters The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster ... 01/26/06 - 20060021071 - Cell in which genome is modified The present invention provides a cell capable of controlling the sugar chain structure of a glycoprotein which is a producing protein, that is, a cell capable of producing a glycoprotein having high physiological activity; a process for producing a glycoprotein using the cell; a glycoprotein produced by the process; and ... 01/12/06 - 20060010506 - Method for improving protein production The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or ... 12/29/05 - 20050289659 - Cre-lox based method for conditional rna interference The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. Vectors for use in conditional expression of a coding sequence based on a strategy in which the mouse U6 promoter is modified to include a hybrid between a LoxP site and a TATA box, and ... 12/29/05 - 20050289658 - System for regulating in vivo the expression of a transgene by conditional inhibition The present invention relates to novel constructs and compositions and to a novel method for regulating the expression of a transgene of interest in vivo by conditional inhibition, and to the uses thereof in experimental, clinical and therapeutic domains or for the production of animals or plants. For example, the ... 12/22/05 - 20050283845 - Method for producing non-human mammal having rnai phenotype It is an object of the present invention to develop a novel method for producing mammals such as mice having an RNAi phenotype, thereby enabling the production of RNAi-expressed progenies by a new mechanism to transfer information to progenies, and to improve a method for introducing dsRNA to improve the ... 12/22/05 - 20050283844 - Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof Methods and compositions are provided for circularizing target sequences in a sample. In particular, ligation oligonucleotides are employed to selectively hybridize with the target such that the target can be ligated into a closed circular target. Rolling circle amplification can then be performed directly on the target sequence for subsequent ... 12/22/05 - 20050283843 - Novel nuclear transfer technique through the processes of enucleation after activation to produce cloned mammals The present invention relates to a method for producing a mammal reconstruction cell, a method for producing a nuclear transferred (NT) embryo capable of developing into a non-human mammal, a method for producing a non-human mammal fetus, a method for producing a non-human mammal and the products prepared by the ... 12/15/05 - 20050278796 - Fiat nucleic acids and proteins and uses thereof The invention provides FIAT nucleic acids and proteins, and methods of using such nucleic acids and proteins. ... 11/24/05 - 20050262579 - Novel clock gene promoter The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene. The screening method uses ... 11/17/05 - 20050257278 - Transgenic non-human animals expressing a truncated activin type ii receptor The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of ... 11/17/05 - 20050257277 - Regulation of transcription with a cis-acting ribozyme The present invention provides a recombinant transcription unit capable of producing an RNA transcript of a predetermined size comprising a regulatory sequence operably linked to a nucleotide sequence comprising a transcribed region such that the transcription of said transcribed region is controlled by said regulatory sequence. The transcribed region comprises ... 10/20/05 - 20050235371 - Noval modified msp-1 nucleic acid sequences and methods for increasing mrna levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell culture systems, or in transgenic animals. The preferred protein candidates for ... 10/20/05 - 20050235370 - Spatiotemporally controlled adult somatic mutagenesis system The present invention relates to an inducible and reversible gene knockdown system. The target gene is under the control of a suppressor which is regulated by a repressible promoter with the repressible promoter being under the control of a transcription-activating gene to activate gene expression and a transcriptional repressor to ... 10/20/05 - 20050235369 - Gene regulation ii We describe a transgenic non-human animal comprising a heterologous nucleic acid binding polypeptide which binds to a target gene and modulates its expression, in which the heterologous nucleic acid binding polypeptide is encoded by a transgene, and in which the expression of a target gene in at least one cell ... 10/13/05 - 20050229266 - Method for producing non-human mammal rnai phenotype using papilloma virus vector It is an object of the present invention to improve a method for introducing dsRNA, so as to improve the efficiency of obtaining mammals such as mice having an RNAi phenotype. The present invention provides a method for producing a non-human mammal wherein the function of a target gene is ... 09/22/05 - 20050210537 - Pluripotent mammalian cells The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the production of pluripotent stem cells from many mammalian species but has particular application in man where pluripotent stem cell ... 09/01/05 - 20050193431 - Somatic cell line The invention features a purified embryonic or fetal caprine somatic cell. The somatic cell can be in a preparation of embryonic or fetal caprine somatic cells. In addition, the cell can be used to derive an embryonic or fetal caprine somatic cell line. The somatic cell can be a genetically ... 08/25/05 - 20050188428 - Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of ... 08/11/05 - 20050177882 - Method and system for fusion and activation following nuclear transfer in reconstructed embryos The present invention provides data to demonstrate that the re-fusion, of a mammalian karyoplast to an enucleated in vivo ovulated cocyte, following an unsuccessful initial simultaneous electrical fusion and activation event offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production ... 08/04/05 - 20050172346 - Method for treating a condition with a socs-3 promoter linked to a polynucleotide encoding socs-3 Disclosed is a nucleic acid construct comprising a murine SOCS-3 promoter sequence having SEQ. ID. NO.:1, or a non-murine homologue thereof, or an operative fragment or derivative. The construct can also contain, operatively linked to the SOCS-3 promoter, a gene encoding any preselected protein, and optionally contains a reporter gene ... 07/14/05 - 20050155093 - Rabbit nuclear cloning method and uses thereof The invention concerns a method for producing non-human mammal embryos, in particular rabbit by nuclear cloning. The invention also concerns the mammals obtained and their uses. ... 07/14/05 - 20050155092 - Desmin gene having novel point mutation causative of dilated cardiomyopathy The present invention is intended to elucidate the cause of severe cardiomyopathy in subline (T) not manifesting the macroscopic cardiac hypertrophy, which has been separated from a hamster (B) with hypertrophic cardiomyopathy and clarify the pathogenic cause of dilated cardiomyopathy, thereby establishing a method of detecting and identifying dilated cardiomyopathy ... 07/07/05 - 20050149998 - Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portion of a first region of ... 06/09/05 - 20050125849 - Stem cell-specific promoters and their use The present invention relates to a method of isolating stem cells from a mixed population of different cell types. This method involves selecting a promoter which functions only in said stem cells and not in the other cell types. The promoter can have a nucleotide sequence selected from the group ... 06/02/05 - 20050120399 - Unactivated oocytes as cytoplast recipients for nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a ... ### FreshPatents.com Support |