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Multicellular Living Organisms And Unmodified Parts Thereof And Related Processes > Nonhuman Animal > The Nonhuman Animal Is A Model For Human Disease The Nonhuman Animal Is A Model For Human DiseaseThe Nonhuman Animal Is A Model For Human Disease patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.11/22/07 - 20070271620 - Animal model for type ii diabetes mellitus and syndrome x and methods and uses thereof The invention provides a method for generating a type II diabetes mellitus and/or Syndrome X model in pigs. A method of the invention comprises partially destructing pancreatic beta-cells in pigs. From these pigs, a pig is preferably selected that comprises a fasting plasma glucose level higher than 6 mmol/L. The ... 08/16/07 - 20070192879 - Transgenic non-human mammal An object of the present invention is to provide a model animal of Parkinson's disease comprising an α-synuclein gene introduced therein. The present invention provides a transgenic non-human mammal or a portion thereof, wherein an α-synuclein gene is introduced and the gene is expressed in neurons, and the number of ... 07/05/07 - 20070157324 - Human disease modeling using somatic gene transfer This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing are provided for. ... 05/10/07 - 20070107069 - Animal model having a chimeric human liver The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in ... 04/05/07 - 20070079391 - Hyperlipemia/hyperalbuminemia model animal The present invention provides a hyperlipemia and/or hyperalbuminemia animal model that is useful for the development of preventive/therapeutic drugs for hyperlipemia and hyperalbuminemia, and in particular, that develops hyperlipemia and hyperalbuminemia at the stage of senility (advanced age) (in case of human, middle-aged and elderly). The hyperlipemia and/or hyperalbuminemia animal ... 04/05/07 - 20070079390 - Animal model for schizophrenia The invention is an animal model which exhibits neuropathological and behavioral features associated with human schizophrenia. The invention also encompasses an in vivo method of preparing an animal model of human schizophrenia. Such a model is useful for screening and identifying therapeutic agents for treating human schizophrenia. ... 02/15/07 - 20070039062 - Goodpasture's syndrome model mouse The present invention provides a non-human model animal of Goodpasture's syndrome that contributes to the treatment of Goodpasture's syndrome where the development of therapy had been delayed due to the lack of adequate disease models, a method for screening a remedy for Goodpasture's syndrome by using the model animal, and ... 11/02/06 - 20060248604 - Adeno-associated virus-delivered ribozyme compositions and methods of use Provided are methods for the identification of novel genes involved in a variety of cellular processes, including retinal degeneration, retinal disease, cancer, memory and learning, amylotropic lateral sclerosis, and methods for the identification of the function of a variety of genes and gene fragments of unknown function. The genes thus ... 08/31/06 - 20060195916 - Transgenic animal as a model for fibrotic diseases Disclosed is a transgenic non-human animal with broad or cell type-specific ectopic expression of fra-2 that manifests itself in a fibrotic disease, methods for obtaining such animal and their use. Fra-2 transgenic animals, in particular mice, are useful as model systems for human fibrotic disease, e.g. lung scleroderma and pulmonary ... 07/20/06 - 20060161998 - Non-traumatic model for neurogenic pain A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into the fascial tunnel through which the peripheral nerve passes. The placement of the gel substance leads to one or more ... 06/29/06 - 20060143719 - Use of golden hamster as infectivity model of sars A model system for sudden acute respiratory syndrome infection (SARS) in humans, comprising a non-human animal infected with a SARS-causing coronavirus (CoV), wherein the non-human animal is a golden hamster. ... 06/15/06 - 20060130161 - Animal model systems for viral pathogenesis of neurodegeneration, autoimmune demyelination, and diabetes Provided are non-human animal model systems for viral pathogenesis of neurodegeneration, autoimmune demyelination, and autoimmune diseases such as diseases of the central nervous system, including multiple sclerosis (MS), and diabetes. Such non-human animal model systems may be suitably employed for the study of diseases such as MS and diabetes and ... 03/09/06 - 20060053501 - Method for detecting nipah virus and method for providing immunoprotection against henipa viruses The present invention provides an animal model for monitoring Nipah virus infection, a method for the quantitative detection and rapid characterization of Nipah virus RNA in a sample, a composition which can be used to provide immunoprotection in an individual as well as monoclonal antibodies which neutralize Nipah and Hendra ... 02/16/06 - 20060037086 - Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals The present invention is directed to various methodologies to make NT a practical procedure for animals, specifically, primates including human and non-human primates. Furthermore, the methods and molecular components provided by the present invention provide a practical means for producing embryos with desired characteristics. In a specific embodiment, the methodology ... 11/24/05 - 20050262578 - Non-human animal models of atherosclerosis and methods of use thereof The present invention provides transgenic, non-human animals comprising a transgene that encodes apolipoprotein(a), which animal exhibits an atherosclerotic phenotype. The present invention further provides transgenic, non-human animals comprising a transgene that encodes apolipoprotein(a) and a transgene that encodes apolipoprotein B-100, which animal exhibits an atherosclerotic phenotype. The present invention further ... 10/27/05 - 20050241008 - Transgenic models of alzheimer's disease and uses therefor in the treatment of a variety of neurodegenerative diseases In accordance with the present invention, it is demonstrated that selected mutations such as an Asp->Ala (D664A) mutation in APP (which prevents cleavage at the caspase cleavage site) prevent both hippocampal synaptic loss and dentate gyral atrophy, even though such mutations do not interfere with the production of Aβ or ... 09/08/05 - 20050198696 - Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders A transgenic zebrafish animal model for the study of haemopoietic cell differentiation, control, and screening of therapeutic agents. ... 07/28/05 - 20050166273 - Rat model of diabetic nephropathy A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat ... 06/30/05 - 20050144657 - Rhpv as a model for hpv-induced cancers Provided is an animal model system for the study of papillomaviruses, especially anogenital papillomaviruses, especially those causing anogenital and/or head and neck cancers. The Rhesus papillomavirus (especially RhPV1) is a useful model for human papillomaviruses which cause anogenital infections and cancers of the anogenital region and/or the head, neck and ... 06/23/05 - 20050138678 - Isolation and identification of transcription control elements associated with mouse eosinophil peroxidase expression The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. Such transcription control elements may comprise isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals, as described herein. ... 06/23/05 - 20050138677 - Transgenic animal model for the treatment of skin tumors A novel animal model for the treatment of skin tumors is described. In particular, the invention provides transgenic non-human animals comprising a recombinant nucleic acid molecule containing a nucleic acid sequence encoding at least one of the gene products of the early genes of a virus of the Human Papilloma ... 06/02/05 - 20050120398 - Animal model for hcv infection The present invention relates to a non-transgenic, non-human animal useful as a model for protease activity and for liver damage, including steatosis. ... ### FreshPatents.com Support |