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Multicellular Living Organisms And Unmodified Parts Thereof And Related Processes > Nonhuman Animal Nonhuman AnimalNonhuman Animal patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.09/27/07 - 20070226814 - Fish food for aquatic farms, based on fermented polyunsaturated fatty acids This invention relates to a feed containing at least one biomass that has been obtained by fermentation or oil extracts obtained from the biomass. The feed is rich in long-chain, polyunsaturated omega-3 fatty acids and can contribute to the maintenance of the natural fatty acid profile in farmed fish or ... 05/31/07 - 20070124825 - Use of hepcidin as a regulator of iron homeostasis The invention concerns the use of hepcidin for the diagnosis and therapy of disorders of iron homeostasis. Hepcidin can be used in the treatment of disorders resulting from iron overload while inhibitors of hepcidin can be used in the treatment of anaemia. ... 05/17/07 - 20070113295 - Gene blocking method The invention relates to methods of regulating gene expression, e.g., to turn on or off, or up or down gene expression in an organism when and where desired, without the toxic side effects usually associated with other contemporary methods, such as those toxic side effects caused by introducing compounds that ... 05/03/07 - 20070101448 - Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use The present invention is directed to a synthetic apolipoprotein-E mimicking polypeptide consisting of a single domain. The invention is also directed to nucleic acid encoding the polypeptide, vectors including the nucleic acid, antibodies specific for the polypeptide, and compositions comprising the same and methods of using the same. ... 05/03/07 - 20070101447 - Diagnostic tests for the detection of motor neuropathy The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to diagnose distal hereditary motor neuropathy type II by detecting polymorphisms in HSP22 gene. ... 04/12/07 - 20070083940 - Transformed silkworm producing human collagen The present invention provides a transformed silkworm which has a polynucleotide encoding human collagen within the genomic DNA and produces recombinant human collagen as a part of proteins in the cocoon or the silk gland; a process for producing recombinant human collagen by using this transformed silkworm; and a recombinant ... 03/15/07 - 20070061901 - Methods to inhibit growth of prostate cancer cells A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The ... 02/08/07 - 20070033663 - Es cells having enhanced rnai effect The object of the present invention is to provide ES cells and mammals having enhanced RNAi effect, which can be used to analyze gene functions at an individual level. The present invention provides ES cells having enhanced RNAi effect, which are obtained by performing genetic manipulation on ES cells. ... 02/08/07 - 20070033662 - Glp-2 receptor gene promoter and uses thereof The invention is directed to the promoter region of the GLP-2 receptor gene and uses thereof. ... 01/25/07 - 20070022482 - High-throughput functional analysis of gene expression The invention is directed to an in vivo functional genomics screen for extracting functional information from a global gene expression profiling dataset in a high-throughput manner. ... 12/28/06 - 20060294601 - Compositions, organisms and methodologies employing a novel human kinase This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several protein kinases. The gene encoding this novel protein kinase is localized in or near the 3p23 locus of the human chromosome 3. The ... 12/21/06 - 20060288431 - Marker for undifferentiated state of cell and composition and method for separation and preparation of stem cells A gene is provided, which can be used as a marker for determining whether a certain cell, particularly an undifferentiated cell including a tissue stem cell, has pluripotency or an undifferentiated state. The gene is called Stm and includes a Stm1 gene, which is expressed specifically in a cell under ... 12/07/06 - 20060277613 - Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals Novel double and triple fusion reporter gene constructs harboring distinct imageable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies. ... 11/30/06 - 20060272037 - Millisecond activation switch for seven-transmembrane proteins The present invention relates to recombinant seven-trans-membrane receptor, whereby the amino terminus of said recombinant receptor is located on an extracellular side and the carboxy-terminus is located on an intracellular side of a membrane, comprising at least two detectable labels, whereby a first of said at least two detectable labels ... 11/23/06 - 20060265764 - Probe for detecting and quantifying lipid second messenger and method of detecting and quantifying lipid second messenger using the same The present invention provides probes for detection and quantification of a lipid second messenger, which comprises: a polypeptide specifically bound to the lipid second messenger; two chromophores respectively having different fluorescence wavelengths, wherein each of the chromophores is linked to each end of the polypeptide through a rigid linker sequence; ... 11/16/06 - 20060259988 - Use of dg931 protein for treating diabetes, obesity and metabolic syndrome The present invention discloses proteins secreted by the developing pancreas, and polynucleotides, which identify and encode these proteins. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders. T ... 11/16/06 - 20060259987 - Variants of antithrombin iii Disclosed are compositions and methods related to variant antithrombin III molecules. ... 11/09/06 - 20060253912 - Nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro Aspects of the present invention relate to nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro. The present invention also concerns novel homodimeric and heterodimeric polypeptides and their use for altering mammalian ovarian follicular growth in vivo or in vitro. ... 11/09/06 - 20060253911 - Novel rna polymerase iii promoter, process for producing the same and method of using the same The present invention provides an RNA polymerase III promoter characterized in that a part of its sequence is substituted with a sequence capable of undergoing specific DNA recombination by Cre recombinase in such a manner functions of PSE and a TATA box are not impaired. This RNA polymerase III promoter ... 11/02/06 - 20060248603 - Novel fibrillin-like polypeptides The present invention discloses open reading frames (ORFS) in human genome encoding for novel fibrillin-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical ... 11/02/06 - 20060248602 - Bitter taste receptors The present invention relates to novel bitter taste receptors and corresponding agonists as well as processes employing these bitter taste receptors in processes directed at the identification of antagonists and agonists. The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to ... 11/02/06 - 20060248601 - Modification of organelle metabolism by unc-51-like kinases roma1 or 2tm proteins The invention discloses polypeptides (Unc-51 kinase, ROMA1, and/or 2TM protein) affecting the activity of Uncoupling Proteins (UCPs), thereby leading to an altered mitochondrial activity and thus contributing to membrane stability and/or function of organelles, preferably mitochondria. This invention relates to the use of these polypepetides in the diagnosis, study, prevention, ... 10/26/06 - 20060242718 - Socs-box containing peptides The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present ... 10/26/06 - 20060242717 - Expression systems A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of ... 10/19/06 - 20060236410 - Protein specific for cardiac and skeletal muscle The present invention relates to a muscle-specific protein, Ozz, and nucleic acids encoding the protein, that regulates development and function of muscle cells. The invention further relates to muscle-specific regulated expression of the protein, and of heterologous genes under control of the same regulatory sequences. In a specific example, a ... 10/12/06 - 20060230465 - K203 gene and protein The present invention is directed to the human and murine K203 protein and gene and to K203 binding compounds. Furthermore, the present invention relates to a pharmaceutical and diagnostic composition for use in the diagnosis and treatment of cancer as well as to a method for the diagnosis of cancer ... 09/21/06 - 20060212948 - Method of constructing nuclear-transplanted egg parthenogenetic embryo and parthenogenetic mammal The present invention is to provide a method of constructing a nucleus-implanted egg, a parthenogenetic embryo and a parthenogenetic mammal each having 2 haploid genome sets originating in mammarian ova, and provides methods of constructing a nucleus-implanted egg having a haploid genome set derived from ng ovum and a haploid ... 09/14/06 - 20060206948 - Compositions for blocking the inhibitory effect of human crp on human leptin Leptin controls the production of C-Reactive Protein (CRP), which, in turn, interacts with leptin to diminish its ability to signal satiety and reduce food intake. The interactions between leptin and CRP can be exploited to screen for agents capable of disrupting the leptin-CRP interaction, and thereby improve leptin signaling. Such ... 08/31/06 - 20060195915 - Novel neurotrophic factor protein and uses thereof The present invention discloses a novel neurotrophic factor protein, MANF2 and a genetic sequence encoding the same. The molecule will be useful in the development of a range of therapeutics and diagnostics useful in the treatment, prophylaxis and/or diagnosis of MANF2 dependent conditions. The molecule of the present invention is ... 08/24/06 - 20060191027 - Cystine-knot polypeptides: cloaked-2 molecules and uses thereof The present invention relates to novel Cloaked-2 polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing Cloaked-2 polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with Cloaked-2 polypeptides. ... 08/17/06 - 20060185025 - Human artificial chromosome (hac) vector The present invention relates to a human artificial chromosome (HAC) vector and a method for producing the same. The present invention further relates to a method for introducing foreign DNA using a human artificial chromosome vector and a method for producing a cell which expresses foreign DNA. Furthermore, the present ... 07/27/06 - 20060168669 - Gene silencing Provided are methods of screening for the occurrence of gene silencing (e.g. post transcriptional gene silencing) in an organism (e.g. a plant or animal), which method comprises the steps of: (i) obtaining a sample of material from said organism, (ii) producing a nucleic acid extract from said sample, (iii) analysing ... 07/27/06 - 20060168668 - Phosphodiesterase 2a and methods of use The invention relates to phosphodiesterase PDE2A isoforms, as well as nucleic acids encoding such polypeptides. The invention further relates to methods for utilizing such polypeptides in diagnostic assays and in methods of screenin potential modulators, especially inhibitors, of the novel PDE2A disclosed herein. The polypeptides of the invention are involved ... 07/27/06 - 20060168667 - Minibrain homologous proteins involved in the regulation of energy homeostasis The present invention discloses minibrain homologous proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention; and treatment of metabolic diseases and disorders. ... 07/13/06 - 20060156423 - Method of screening antiobesity agents and animal model of obesity A promoter for an angiopoietin-related growth factor (AGF), a vector comprising the promoter, a transformant comprising the promoter, and a method for screening an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent by using the transformant, are disclosed. Further, an AGF knockout animal useful as an animal model for ... 07/06/06 - 20060150262 - Novel mucin-like polypeptides The present invention discloses open reading frame (ORFs) in human genome encoding for novel mucin-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical ... 06/15/06 - 20060130160 - Full-length human cdnas encoding potentially secreted proteins The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for ... 06/08/06 - 20060123492 - Methods of identifying modulators of nmur2-mediated activity Methods for screening for agents capable of modulating human neuromedin U receptor 2 (NMUR2) activity are provided, as well as therapeutic methods for treating NMUR2-mediated conditions. More specifically, methods are provided for identifying agents capable of inhibiting NMUR2-mediated pain or nociception. ... 06/08/06 - 20060123491 - Method for a (high through-put) screening detection of genetic modifications in genome engineering The present invention is related to a method for a high through-put screening detection of genetic modifications in genome engineering and a system for homologous recombination of an exogenous nucleotide sequence into a target cell genome sequence. ... 06/08/06 - 20060123490 - Pluripotent cells with improved efficiency of homologous recombination and use of the same The present invention provides a method of enhancing an efficiency of homologous recombination when a gene encoding a desired protein known or unknown in terms of function is introduced into a genome of a pluripotent cell such as ES cell. More particularly, the present invention relates to: a non-human animal-derived ... 06/08/06 - 20060123489 - Sex-specific automated sorting of non-human animals The present invention relates to populations of male and female non-human animals which can be induced to produce single sex populations, and which may comprise a heterologous gene of interest, preferably a neurodegenerative disease gene, which is expressed in a tissue specific manner. The invention also relates to methods for ... 06/01/06 - 20060117396 - Assay methods for identifying modulators of opsdl3 and transgenic knockouts Methods for treating or alleviating pain by treating a subject in need thereof with an agonist of OPSDL3 activity or expression. Further provided are screening methods for identifying agents capable of activating OPSDL3, and transgenic non-human animals which homozygous for deletion of the endogenous OPSDL3 gene and/or comprise a human ... 05/11/06 - 20060101529 - Lymphocyte surface receptor that binds caml and methods of use thereof A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, is shown to increase lymphocyte response, and to identify ligands of the protein receptor. Antibodies to the proteins of the invention are generated for ... 05/11/06 - 20060101528 - Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterised in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of ... 04/13/06 - 20060080744 - Novel chemokine-like polypeptides The present invention discloses open reading frames (ORFs) in human genome encoding for novel chemokines-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical ... 03/30/06 - 20060070132 - Methods for producing proteins using silkworm middle silk gland-specific gene expression system Transgenic silkworms comprising GFP whose expression is regulated by the sericin gene promoter were produced. Observation of the silk glands of the last instar larvae of the silkworms showed fluorescence only in the middle silk glands. GFP was secreted from middle silkgland cells from around the spinning stage, indicating that ... 03/09/06 - 20060053500 - Modification of sugar metabolic processes in transgenic cells, tissues and animals The present invention provides natural or transgenic galactose deficient cells, tissues, organs and animals that have been genetically modified to compensate for the abnormalities in galactose metabolic pathways. The present invention modifies sugar metabolic pathways to to prevent the deleterious accumulation of sugar metabolites in animals, tissues, organs, cells and ... 03/09/06 - 20060053499 - An invertebrate animal model with neurodegenerative phenotype for screening and testing substances The present invention claims an invertebrate animal that has been modified to express a set of genes, said set comprising the gene coding for a modified version of the gamma subunit of AMP-activated protein kinase (AMPKg). According to the invention, the animal displays an identifiable phenotype related to lipid metabolism ... 03/09/06 - 20060053498 - Full-length human cdnas encoding potentially secreted proteins The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for ... 03/09/06 - 20060053497 - Salmonella typhimurium-infected caenorhabditis elegans for identifying inhibitors of infection Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that control or regulate genes responsible for establishing a persistent infection, as in the colonization of the gut of the nematode. ... 02/23/06 - 20060041946 - Nuclear transfer nuclei from histone hypomethylated donor cells The present invention provides a method of producing an animal embryo, the method comprising transferring from a nuclear donor cell which has been selected on the basis that it is histone hypomethylated at least a portion of the nuclear contents including at least the minimum chromosomal material able to support ... 02/09/06 - 20060031949 - Inducible expression systems for modulating the expression of target genes in eukaryotic cells and non-human animals The present invention relates to inducible expression systems and to compositions and methods for modulating the expression of at least one target gene in an eukaryotic cell and non-human animal. ... 02/09/06 - 20060031948 - Inducible expression systems for modulating the expression of target genes in eukaryotic cells and non-human animals The present invention relates to inducible expression systems and to compositions and methods for modulating the expression of at least one target gene in an eukaryotic cell and non-human animal. ... 02/09/06 - 20060031947 - Novel mutated mammalian cells and animals Novel mutated mammalian cells are provided that have been characterized by identifying the sequence of the genes that have been mutated. Preferably, novel mutated cells are murine ES cells that stably incorporate retroviral gene trap constructs in the specifically identified genes. The novel mutated cells and animals are useful in ... 02/09/06 - 20060031946 - Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis The present invention provides a method for enhancing the in vivo delivery of chimeric oligonucleotides, containing for example DNA/2′OMeRNA, into cells of a plant, an animal or a human, comprising a step of applying topically to or injecting into a tissue, or tissue adjacent to a tissue, containing said cells, ... 02/09/06 - 20060031945 - Inducible expression systems for modulating the expression of target genes in eukaryotic cells and non-human animals The present invention relates to inducible expression systems and to compositions and methods for modulating the expression of at least one target gene in an eukaryotic cell and non-human animal. ... 01/19/06 - 20060015951 - Proteins involved in the regulation of energy homeostasis The present invention discloses novel uses for energy homeostasis regulating proteins and polynucleotides encoding these in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders. ... 12/22/05 - 20050283842 - Mipp1 homologous nucleic acids and proteins involved in the regulation of energy homeostatis The present invention discloses Mipp1 homologous proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders. ... 12/15/05 - 20050278795 - Stearoyl-coa desaturase 4 gene The cloning of a fourth mouse SCD gene, mSCD4, as well as its corresponding cDNA and amino acid sequences are disclosed. Mouse SCD4 is expressed mainly in the heart tissue and synthesizes the bulk of monounsaturated fatty acids in the heart. The disclosure here enables new tools (e.g., nucleic acids, ... 12/08/05 - 20050273870 - Preparation and selection of donor cells for nuclear transplantation The invention relates to a method of synchronizing a population of somatic cells in G1 for purposes of preparing the cells for nuclear transfer or nuclear transplantation by using mechanical shake-off and selection of mitotic doublet cells. This method may further comprise cooling of the cells or other means of ... 12/08/05 - 20050273869 - Plasmids and phages for homologous recombination and methods of use Lambda phages that can be used to introduce recombineering functions into host cells are disclosed. Also disclosed are plasmids that can be used to confer recombineering functions to a variety of strains of E. coli and to other bacteria, including Salmonella, Pseudomonas, Cyanobacteria, Spirochaetes. These plasmids and phages can be ... 12/08/05 - 20050273868 - Methods and compositions for enhancing risc activity in vitro and in vivo The present invention provides methods of enhancing the efficacy and specificity of RNAi by priming RISC activity in cells, cell extracts, and organisms using priming agents such as siRNAs as well as other nucleic acids. The invention also provides priming agents, extracts and cells with high levels of primed RISC ... 12/08/05 - 20050273867 - Non-invasive real-time in vivo bioluminescence imaging of local ca²+ dynamics in living organisms The present invention also concerns a transgenic non-human animal expressing said recombinant polypeptide sensitive to calcium concentration, in conditions enabling the in vivo monitoring of Ca2+ dynamics. In a particular embodiment, the expression and/or localization of said recombinant polypeptide is restricted to a specific tissue, a single-cell type and/or in ... 11/24/05 - 20050262577 - Polypeptides and nucleic acids encoding these and their use for the prevention, diagnosis or treatment of liver disorders and epithelial cancer The invention relates to polypeptides and nucleic acids encoding these and to their use for the diagnosis, prevention and/or treatment of liver disorders and neoplastic disorders, especially cancer of the liver and other epithelial tissues, benign liver neoplasms such as adenoma and other proliferative liver disorders such as focal nodular ... 11/10/05 - 20050251872 - Lentiviral vectors, related reagents, and methods of use thereof The present invention provides new lentiviral vectors, including lentiviral transfer plasmids and infectious lentiviral particles. Lentiviral vectors of the invention were designed to offer a number of desirable features including reduced size, convenient cloning sites (including multiple cloning sites and sites for particularly useful restriction enzymes), loxP sites, self-inactivating LTRs, ... 11/10/05 - 20050251871 - Novel ubiquitin ligases as therapeutic targets The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, ... 11/10/05 - 20050251870 - Csnk1gs as modifiers of the p21 pathway and methods of use Human CSNK1G genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of CSNK1G are provided. ... 11/03/05 - 20050246780 - Phytases, nucleic acids encoding them and methods for making and using them The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where ... 10/27/05 - 20050241007 - Frog prince, a transposon vector for gene transfer in vertebrates The present invention relates to a transposon-based DNA integration system comprising (a) a transposon which is devoid of a polynucleotide encoding a functional transposase and which comprises a polynucleotide of interest, wherein the transposon comprises inverted repeats having a degree of identity with the repeats within SEQ ID NO: 2 ... 10/20/05 - 20050235368 - Method of transporting transgenic xenopus laeves oocytes A method is disclosed herein of providing transgenic Xenopus laevis oocytes. The method comprises preparing transgenic Xenopus laevis oocytes at a first location and transporting the transgenic Xenopus laevis oocytes to a second location remote from the first location. Preferably, the transgenic Xenopus laevis oocytes are prepared by injecting Xenopus ... 10/20/05 - 20050235367 - Regulatory sequences capable of conferring expression of a heterologous dna sequence in endothelial cells and uses thereof Described are recombinant DNA molecules comprising the regulatory sequence(s) of an intron of the Endothelial Growth Factor (VEGF) receptor-2 gene (Flk-1) or of a gene homologous to the Flk-1 gene, being capable of conferring expression of a heterologous DNA sequence in endothelial cells, preferably in vivo. Vectors comprising said DNA ... 10/13/05 - 20050229264 - Recombinant gelatins The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same. ... 10/13/05 - 20050229263 - Transgenesis by sperm-mediated gene transfer The invention relates to improved methods to integrate heterologous DNA into the genome of non-human animals. The transgenic constructs contain a site recognized by a site specific recombinase which can be used to catalyze the insertion of the transgene into the animal's genome. The transgenic constructs and site specific recombinase ... 10/06/05 - 20050223418 - Porcine cmp-n-acetylneuraminic acid hydroxylase gene The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell lines derived from such animals, tissues, and organs, which lack expression of functional CMP-Neu5Ac hydroxylase. Such animals, tissues, ... 10/06/05 - 20050223417 - Compositions and methods for increasing animal size and growth rate The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growth rate. ... 09/29/05 - 20050216960 - Trail-r as a negative regulator of innate immune cell responses Methods and composition are provided for modulating innate immunity by modulating activation of the TRAIL receptor. Signaling through the TRAIL-R inhibits the responsiveness of cells including dendritic cells, macrophages, and the like. The activity of these cells is increased or decreased by the administration of agents that inhibit or activate ... 09/29/05 - 20050216959 - Particle-mediated transformation of animal somatic cells A method is disclosed for the convenient transformation of the somatic cells of animals. Somatic cell transformation is useful for medical and veterinary care of genetic diseases, and other therapeutic or animal improvement purposes. The method makes use of an electric discharge particle acceleration apparatus which can inject very small ... 09/22/05 - 20050210535 - Toxoplasma gondii apical membrane antigen-1 The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provided. In addition the invention provides methods involving use of the polypeptides, nucleic acids, and ... 09/15/05 - 20050204411 - Human coagulation factor vii polypeptides The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment. ... 09/15/05 - 20050204410 - Sirt6 transgenic non-human animals and assay methods Assay methods for identifying agents capable of modulating SIRT6 activity or expression, as well as non-human transgenic animals useful for identifying agents capable of inhibiting aging-associated degenerative processes. ... 09/15/05 - 20050204409 - Gene for identifying individuals with familial dysautonomia This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is characterized by widespread sensory and variable autonomic dysfunction. Previously, we ... 09/15/05 - 20050204408 - Tropoelastin derivatives The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the invention. The invention further provides methods for the production of the derivatives, variants, expression products and hybrid molecules. Further provided are formulations, ... 09/15/05 - 20050204407 - Methods for identifying and developing compounds that interact with voltage-gated potassium channels of the kv4 family Methods for identifying and developing compounds that interact with voltage-gated potassium channels of the Kv4 family, optionally with auxiliary proteins such as KChiP proteins. Methods for identifying and developing compounds that may interact with voltage-gated potassium channels of the Shal (Kv4) family. Transgenic nematodes of the species Caenorhabditis elegans that ... 09/08/05 - 20050198695 - Nematode atp synthase subunit e-like sequences Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, ... 08/25/05 - 20050188427 - Lysyl oxidase-like 1 (loxl1) and elastogenesis Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fibers. ... 08/11/05 - 20050177880 - Nucleic acid isolated from the 5' nontranslated region (5'ntr) end of the human fgf-1 gene having ires activity The invention relates to an isolated nucleic acid of the human FGF-1 gene having IRES (internal ribosome entry site) activity, said nucleotide sequence being derived from the 5′ non-translated region (5′NTR) end of the human FGF-1 gene. The invention also concerns an expression cassette of at least one molecule of ... 07/28/05 - 20050166272 - Enhancement of rnai activity through mutation A double-stranded RNA comprising an antisense RNA and a sense RNA with specific mutations are disclosed as having enhanced RNAi activities. The double stranded RNA has at least one substitution or insertion mutation introduced at a first, second or third nucleotide position from the 5′ end of the antisense RNA ... 07/28/05 - 20050166271 - Fatty acid desaturase gene obtained from pomegranate and method for the production of unsaturated fatty acids The present invention relates to a process for the production of unsaturated or saturated fatty acids and to a process for the production of oils and/or triglycerides with an increased content of unsaturated or saturated fatty acids. The invention furthermore relates to nucleic acid sequences, nucleic acid constructs, vectors and ... 07/21/05 - 20050160484 - Orphanin fq receptor polypeptides The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences for the identification of pharmaceutical agents and ... 07/14/05 - 20050155090 - Compositions and methods comprising a ligand of chemerinr The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related ... 07/14/05 - 20050155089 - Signal peptide-containing molecules The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. ... 07/14/05 - 20050155088 - Ralstonia ahl-acylase gene This invention provides a gene, qsbA, which encodes a protein useful for inactivating certain bacterial quorum-sensing signal molecules (N-acyl homoserine lactones) which participate in bacterial virulence and biofilm differentiation pathways. This gene was isolated from Ralstonia sp., strain XJ12B. The invention also provides the QsbA protein, which possesses N-acyl homoserine ... 06/30/05 - 20050144656 - Novel use of neuroactive compounds The invention relates to a novel use of neuroactive compounds by treating the fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds strychnine, pentylenetetrazol, tetraethylammonium chloride, lithium carbonate and nicotine, crossing the drug treated males with untreated females to obtain progenies and self-crossing the progenies ... 06/30/05 - 20050144655 - Methods of modifying eukaryotic cells A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically ... 06/23/05 - 20050138676 - Identification of genes involved in alzheimer's disease using drosophila melanogaster Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. ... 06/16/05 - 20050132426 - Long-term cell culture compositions and genetically modified animals derived therefrom The present invention generally relates to neural stem cells, preferably fetal neural stem cells and their progeny thereof. The present invention provides methods of isolating culturing and propagating neural stem cells and the development of neural stem cell lines and lineages. The present invention also relates to the use of ... 06/16/05 - 20050132425 - Transgenic flies expressing abeta42-italian The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of ... 06/16/05 - 20050132424 - Transgenic flies expressing abeta42-dutch The present invention discloses a transgenic fly that expresses the Dutch mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Dutch peptide of human amyloid-β precursor protein (APP). The transgenic flies of ... 06/16/05 - 20050132423 - Transgenic flies expressing abeta42-flemish The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of ... 06/16/05 - 20050132422 - Transgenic flies expressing abeta42-iowa The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Iowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of ... 06/16/05 - 20050132421 - Transgenic flies expressing abeta42-arctic The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of ... 06/09/05 - 20050125848 - Method of isolating human neuroepithelial precursor cells from human fetal tissue A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells ... 06/09/05 - 20050125847 - Use of coral red fluorescence proteins as tracers for easy identification of genetic modified baculoviruses The present invention provides a method of tracking the presence of genetic modified baculoviruses (GMBVs) in pest insects, comprising infecting the pest insects with GMBVs, which are engineered to express tracer proteins, i.e., coral red fluorescence proteins. The color of the expressed coral red fluorescence proteins are red or pink ... 06/09/05 - 20050125846 - Thyroid sodium/iodide symporter and nucleic acid encoding same The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention ... 06/02/05 - 20050120397 - Compounds and methods for regulation of spermatid differentiation The present invention provides methods for the regulation of spermatid differentiation. This invention also provides applications of regulated spermatid differentiation, including the treatment of infertility, contraception and pest control. This invention also describes agents for effecting such methods and compositions comprising same. ... 06/02/05 - 20050120396 - Human mekk1 protein and nucleic acid molecules and uses therefor Isolated nucleic acid molecules encoding human MEKK1, and isolated human MEKK1 proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human ... 06/02/05 - 20050120395 - Method for genetically modifying a target population of an organism A method for genetically modifying a target population of an organism, comprising the steps of 1. providing a modified organism, wherein the modified organism is capable of sexually reproducing with an organism of the target population, and wherein a selected gene in the germline of the modified organism is disrupted ... 06/02/05 - 20050120394 - System for achieving high expression of genes The present invention relates to a method of expressing a gene by inserting the genome into a host organism using genetic engineering techniques. The present invention further relates to a novel promoter, a recombinant vector containing the promoter and a target gene, a transformant containing the recombinant vector, and a ... 06/02/05 - 20050120393 - Full-length prostate selective polynucleotides and polypeptides The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ... ### FreshPatents.com Support |