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Multicellular Living Organisms And Unmodified Parts Thereof And Related Processes > Method Of Using A Transgenic Nonhuman Animal To Manufacture A Protein Which Is Then To Be Isolated Or Extracted > The Protein Is Isolated Or Extracted From Blood Or Serum > The Protein Is An Immunoglobulin The Protein Is An ImmunoglobulinThe Protein Is An Immunoglobulin patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.11/15/07 - 20070266448 - Method for the production of antibodies The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently ... 11/01/07 - 20070256145 - Mammalian transforming growth factor beta-9 Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies. ... 08/16/07 - 20070192878 - Clarification of transgenic milk using depth filtration Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various feedstreams for the removal of a molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is ... 06/07/07 - 20070130628 - Method for producing immortalised antibodies-secreting cells A method for producing immortalized antibody-secreting cells, comprising: (a) providing a transgenic animal having antibody-secreting cells capable of expressing one or more transgenes, wherein the antibody-secreting cells are in a non-immortalized state in the absence of a stimulus and are capable of changing to an immortalized state by means of ... 05/03/07 - 20070101446 - Antibodies against epitopes with homology to self antigens, methods of preparation This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal that does not biosynthesize at least one epitope of the antigen and utilizes the lack of self-tolerance of the host to the epitope to produce ... 03/22/07 - 20070067854 - Chimeric mouse having an immune system constructed with human cd34+ cells and use thereof Chimeric mice were constructed by transferring human CD34+ cells (hematopoietic stem cells) into a SCID mouse. In these chimeric mice, hematopoietic stem cells persistently differentiated into immune cells. Consequently, the chimeric mice can be immunized over a long time and enable one to obtain human antibodies against arbitrary antigens containing ... 03/15/07 - 20070061900 - Methods of modifying eukaryotic cells A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically ... 03/15/07 - 20070061899 - Transgenic mammal with constitutive, tissue-specific cytokine expression and use as a cancer model The invention is directed to a transgenic non-human mammal with constitutive, tissue-specific cytokine expression and the use of the transgenic mammal as a model for spontaneous development of cancer. Particularly, the invention provides for a transgenic mouse where specific expression of interlueukin-1β in the stomach results in the development of ... 02/08/07 - 20070033661 - Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several human or humanized immunoglobulin transloci. This can be done by overexpressing the apoptosis inhibitor, i.e. ... 01/11/07 - 20070011753 - Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the ... 12/21/06 - 20060288430 - Animals, cells and methods for production of detectably-labeled antibodies Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is ... 09/14/06 - 20060206947 - Heterodimeric protein binding compositions The invention relates to methods for making modified immunoglobulin compositions to maximize antigen binding and effector function by swapping of sequences of the heavy and light chains within an IgG Fab domain for the purpose of reorienting the Fc domain relative to the antigen-binding domain. ... 08/24/06 - 20060191025 - Method for the rapid selection of homozygous primary cell lines for the production of transgenic animals by somatic cell nuclear transfer The present invention provides for the production of homozygous primary cells that carry a specific transgenic integration of interest on both chromosomes by bypassing breeding. These cell lines can they be used for the accelerated production of homozygous transgenic animals by somatic cell nuclear transfer. The invention is thus useful ... 08/24/06 - 20060191024 - Method for preparing anti-mif antibodies The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF−/−). Also provided are methods of preparing hybridomas which produce the anti-MIF antibodies, methods of administering the antibodies to treat inflammatory or cancerous conditions ... 07/20/06 - 20060161997 - Methods for producing human antibodies in scid mice An improved method for producing human antibodies in SCID mice is provided. The improvement includes the use of dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents. ... 07/20/06 - 20060161996 - Process for producing human-origin immunocompetent cell It is an object of the present invention to provide an immunodeficient animal capable of generating human-derived lymphoid cells, a human-derived lymphoid cell, and a method for producing a human antigen-specific antibody. The means for solving the aforementioned object is: an immature immunodeficient mammal into which human-derived hematopoietic precursor cells ... 07/20/06 - 20060161995 - Artificial human chromosome containing human antibody a light chain gene The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing ... 07/13/06 - 20060156422 - Methods and compositions for the generation of antibodies The present invention relates to a novel method for the generation of monoclonal antibodies. In particular the invention relates to a novel method for the generation of monoclonal antibodies from non-human somatic transgenic animals. Uses of antibodies generated using the method of the invention are also described. ... 07/06/06 - 20060150261 - Intracellular antibodies for a retrovirus protein A transgenic organism is provided comprising a polynucleotide construct encoding an intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose α 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds specifically to a retrovirus protein, such as a PERV particle protein. Also ... 06/15/06 - 20060130157 - Ungulates with genetically modified immune systems The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from ... 06/01/06 - 20060117395 - Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, ... 06/01/06 - 20060117394 - Expression of xenogenous (human) imunoglobulins in cloned, transgenic ungulates The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, ... 03/16/06 - 20060059575 - Method for preparing monoclonal antibody A significantly increased amount of a monoclonal antibody is obtained from the culture medium of recombinant hybridoma prepared by introducing genes encoding a protein identical to the immunoglobulin heavy chain polypeptide of the specific monoclonal antibody into an immortalized B cell (hybridoma) producing the monoclonal antibody. ... 02/23/06 - 20060041945 - Transgenic animals and uses thereof In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein. ... 02/02/06 - 20060026698 - Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ... 02/02/06 - 20060026697 - Genetic immunization of transgenic animals with non-eukaryotic expression systems The present disclosure is directed to novel methods for genetic immunization which utilize a eukaryote host with a non-eukaryotic expression system. Preferably the non-eukaryotic expression system is a bacteriophage RNA Polymerase, for example T7 RNA Polymerase, which is preferably expressed in specific tissue(s) of the host. Genetic immunization occurs when ... 02/02/06 - 20060026696 - Humanized immunoglobulin loci The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations. ... 01/19/06 - 20060015950 - Nuclear transfer embryo formation method A nuclear transfer embryo is formed by destabilizing microtubules of an oocyte, whereby essentially all endogenous chromatin collects at a second polar body during meiosis of an oocyte. The oocyte is fused with the nucleus of a donor somatic cell of the same species of said oocyte prior to cessation ... 01/19/06 - 20060015949 - Transgenic non-human animals for producing heterologous and chimeric antibodies The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity. ... 10/27/05 - 20050241006 - Human antibodies derived from immunized xenomice Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either ... 09/29/05 - 20050216958 - Cells of which genome is modified A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain ... 07/21/05 - 20050160483 - Transgenically produced decorin Transgenically produced decorin and methods of making and using transgenically produced decorin. ... 07/07/05 - 20050149996 - Generation of chicken cell lines from embryonic stem cells and germ cells The invention provides compositions of chicken cell lines and methods of production and use thereof. The cell lines are obtained from chicken germ cells or embryonic stem cells. The methods of the invention include a method of creating a chicken cell line, a method of propagating a pathogen, and a ... ### FreshPatents.com Support |