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Prosthesis (i.e., Artificial Body Members), Parts Thereof, Or Aids And Accessories Therefor > Arterial Prosthesis (i.e., Blood Vessel) > Drug Delivery Drug DeliveryDrug Delivery patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.12/14/06 - 20060282160 - Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-based polymeric coating facilitates the performance of such devices in inhibiting restenosis. ... 11/16/06 - 20060259130 - Device for blocing blood vessel Disclosed is a device for occlusion of blood vessel comprising a metallic coil, a sustained-release element and a cell growth factor. Examples of the cell growth factor include basic fibroblast growth factor (bFGF), acidic fibroblast growth factor (aFGF), platelet-derived growth factor (PDGF), transforming growth factor β1 (TGC-β1), vascular endothelia growth ... 10/26/06 - 20060241742 - Stent comprising a coating system A stent comprises a tubular base body which is open on the front sides thereof and has a peripheral wall that is at least partially covered with a coating system consisting of at least one polymer carrier and at least one pharmacologically active substance, which is released into the surrounding ... 10/19/06 - 20060235507 - Overlapping coated stents The present invention avoids a patient receiving a double dose of a therapeutic agent when a coated stent is overlapped with another coated stent within a vessel. A stent having a therapeutic coating on a portion of the stent is delivered within a vessel such that the portion of the ... 10/12/06 - 20060229713 - Implantable medical device with openings for delivery of beneficial agents with combination release kinetics A method and system for delivering drug includes a first set of holes filled with a first formulation of the drug and a second set of holes filled with a second formulation of the same drug. This dual formulation or dual release kinetic system allows the creation of specifically tailored ... 10/12/06 - 20060229712 - Method of stent mounting to form a balloon catheter having improved retention of a drug delivery stent A method of mounting a drug delivery stent on a balloon of a balloon catheter. The method securely mounts the drug delivery stent on the balloon without damaging the drug delivery layer of the stent. In one embodiment, the method generally comprises positioning a drug delivery stent on a balloon ... 09/28/06 - 20060217798 - Stent having active release reservoirs Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release. ... 09/28/06 - 20060217797 - Asymmetric drug eluting hemodialysis graft A hemodialysis graft has one end provided with a deposit containing an anti-stenotic agent. The coated end is connected to a vein to provide protection against stenosis occurring at the venous anastomosis. ... 09/07/06 - 20060200232 - Nanofibrous materials as drug, protein, or genetic release vehicles The present invention is a bioactive, nanofibrous material construct which is manufactured using an unique electrospinning perfusion methodology. One preferred embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a biodurable synthetic polymer; (ii) a biologically active agent; and (iii) ... 09/07/06 - 20060200231 - Stent coating for eluting medication A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that ... 08/17/06 - 20060184236 - Intraluminal device including an optimal drug release profile, and method of manufacturing the same An intraluminal device, an intraluminal stent delivery system, and a method of manufacturing the same. The device includes a body. At least one therapeutic agent coating is positioned on the body and positioned substantially on an interface portion to provide an optimal drug release profile. The stent delivery system includes ... 08/10/06 - 20060178736 - Stent for neutron capture therapy and method of manufacture therefor Improved method and apparatus for neutron capture therapy are disclosed, which may beneficially be used to counteract restenosis. An improved stent and a method for manufacturing the stent are also presented. The stent comprises a stable nuclide having a large neutron capture cross-section. When a clinical need exists for radiation ... 08/10/06 - 20060178735 - Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor A method for treating blood vessel occlusions in the heart delivers an angiogenic agent from an implantable device locally to the walls of the blood vessel over an extended administration period sufficient to establish self sustaining blood vessels. An expandable medical device for delivery of angiogenic agents includes openings in ... 08/10/06 - 20060178734 - Methods of delivering anti-restenotic agents from a stent A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended, and substantially linear drug release profile. The method ... 07/13/06 - 20060155369 - Selective adherence of stent-graft coverings An endoluminal prosthesis including a first polymer member bonded to a second polymer member to selectively encapsulate a stent. Selective bonding between the first and second polymer members results in unbonded regions or pockets that accommodate movement of the stent, permitting compression of the prosthesis using minimal force and enabling ... 06/29/06 - 20060142850 - Functionalisation of stents with lipases The invention relates to intravascular stents having in an inner surface an enzyme capable of catabolizing cholesterol and lipids, such as lipase, or cells that have been genetically modified to produce the enzyme, and to their use in the treatment or prevention of obstructive artheriosclerotic lesions in coronary and peripheral ... 06/22/06 - 20060136051 - Coated medical device A stent that is adapted for introduction into a body passageway and which releases at least one biological agent after being inserted in the body passageway. The release of the at least one biological agent can be a controlled release via molecular diffusion through a non-porous polymer layer. ... 06/22/06 - 20060136050 - Autologous growth factors to promote tissue in-growth in vascular device Methods and devices for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed is coating of autologous growth factor compositions onto stent grafts prior to stent graft implantation. Additional embodiments include stent grafts having autologous growth factor ... 06/22/06 - 20060136049 - Implantable systems and stents containing cells for therapeutic uses An implantable system includes cells that produce and release a therapeutic agent, or agents, to a host in need. The system can include cells capable of eluting therapeutic agents in response to changing physiological conditions within a host. The system may comprise naked cells, encapsulated cells, or a mixture of ... 06/22/06 - 20060136048 - Abluminal, multilayer coating constructs for drug-delivery stents Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal ... 06/08/06 - 20060122697 - Expandable medical device with openings for delivery of multiple beneficial agents An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to ... 05/11/06 - 20060100695 - Implantable stent with modified ends A stent is provided with modified ends (782, 786) and enhanced drug delivery. The stent assembly also provides for enhanced overlapping between adjacent stents. ... 04/13/06 - 20060079957 - Intraluminal therapeutic patch The present invention includes systems, methods and apparatus. A system in accord with the present invention may include an intraluminal patch sized to fit within a lumen and an expandable therapeutic delivery device. The patch in this embodiment may have an adhesive region on an exposed surface and a drug ... 02/09/06 - 20060030937 - Carrier and kit for intraluminal delivery of active principles or agents A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance ... 02/09/06 - 20060030936 - Method of making a coated medical device Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at ... 01/26/06 - 20060020329 - Semi-directional drug delivering stents A semi-directional drug delivery stent for selectively delivering one or more therapeutic agents to an area of interest within a bodily or luminal structure is disclosed. In one embodiment, a semi direction drug delivery stent includes a generally cylindrical body defining at least one internal passage positioned longitudinally therein, a ... 01/26/06 - 20060020328 - Composite vascular graft having bioactive agent A composite vascular graft incorporates bioactive agents to deliver therapeutic materials and/or inhibit or reduce bacterial growth during and following the introduction of the graft to the implantation site in a vascular system. A composite vascular graft includes a porous tubular graft member. A flexible ePTFE sheath is disposed over ... 01/19/06 - 20060015174 - Expandable medical device for delivery of beneficial agent An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut ... 01/12/06 - 20060009840 - Carrier for releasing a therapeutic substance in response to the presence of an enzyme A composition that releases a therapeutic substance in response to an enzyme is disclosed. The composition can be, for example, a coating for a stent. ... 01/05/06 - 20060004441 - Therapeutic blood vessel treatment A method and device for the treatment of an aneurysm are provided. Different therapeutic agents are delivered to the aneurysmal site by a delivery vehicle in a localized, time-release regimen, to treat and reduce the severity of the aneurysm. The delivery vehicle is provided in conjunction with the placement of ... 12/15/05 - 20050278016 - Stent designed for the delivery of therapeutic substance or other agents A stent comprising a serpentine portion extending about the circumference of the stent, the serpentine portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween, at ... 12/08/05 - 20050273161 - Electrostatic loading of drugs on implantable medical devices A method for electrostatic loading of drugs on an implantable medical device is disclosed. ... 11/24/05 - 20050261762 - Medical devices to prevent or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain anti-inflammatory agents, are disclosed. The-anti-inflammatory agents are selected from the group consisting of ENMD-0997, gusperimus hydrochloride, BMS-561392, CP-461, RDP-58, CNI-1493, CEP-1347, CMT-3, prinomastat, rebimastat, leflunomide, BX-471, DF-1681, BXT-51072, M-40403, LY-293111 sodium, and pharmaceutically acceptable ... 11/17/05 - 20050256565 - Replenishable stent and delivery system Apparatus and a method for treating an irregularity in a wall of a vessel of a patient defined by an irregular or afflicted wall portion with adjacent normal wall portions comprises a catheter having a distal end portion for being guided through the vessel to the site of the irregularity. ... 11/17/05 - 20050256564 - Intraluminal stent including therapeutic agent delivery pads, and method of manufacturing the same An intraluminal stent, an intraluminal stent delivery system, and a method of manufacturing an intraluminal stent. The stent comprises a body and at least one pad operably attached to the stent body. The pad includes at least one therapeutic agent disposed thereon. The delivery system comprises a catheter and the ... 11/10/05 - 20050251246 - Dilating and support apparatus with disease inhibitors and methods for use A dilating and support apparatus with disease inhibitors and methods for use is disclosed that is particularly useful for repairing and/or serving as a conduit for body passageways that require reinforcement, dilatation, disease prevention or the like. Such apparatuses are utilized to deliver a therapy, that therapy being from a ... 10/20/05 - 20050234544 - Expandable medical device with openings for delivery of multiple beneficial agents An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to ... 10/20/05 - 20050234543 - Plug for use in left atrial appendage A plug or insert occludes the left atrial appendage (LAA), thus preventing blood from entering. The plug is formed in one piece without separately movable parts, and may be monolithic. A drug coating can be provided, with or without a plug. ... 10/13/05 - 20050228490 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain antiproliferative agent, are disclosed. The anti-restenotic antiproliferative agent is BMS-181176, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents ... 10/06/05 - 20050222677 - Coated implantable medical device A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on ... 10/06/05 - 20050222676 - Method and apparatus for loading a beneficial agent into an expandable medical device The present invention relates to method and apparatus for dispensing a beneficial agent into an expandable medical device. The method includes the step of placing an expandable medical device on a support and dispensing a beneficial agent into a plurality of openings in the medical device with a shield gas ... 09/22/05 - 20050209688 - Local vascular delivery of panzem in combination with rapamycin to prevent restenosis following vascular injury Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed ... 09/15/05 - 20050203613 - Drug delivery stent An implantable stent comprises a tubular member having an interior surface and an exterior surface, with a region of at least one of the surfaces being hydrophobic. The region is provided with an array of microstructures or nanostructures that covers first portions of the surface but leaves second portions exposed ... 09/15/05 - 20050203612 - Devices delivering therapeutic agents and methods regarding the same Devices and methods for reducing, inhibiting, or treating restenosis and hyperplasia after intravascular intervention are provided. In particular, the present invention provides luminal prostheses which allow for sustained or controlled release of at least one therapeutic capable agent with increased efficacy to selected locations within a patient's vasculature to reduce ... 09/15/05 - 20050203611 - Synthetic vascular prosthesis The present invention relates to a vascular prosthesis containing an active substance that has the capacity to stimulate the ingrowth of vascular cells, into the prosthesis. The present invention further relates to a method for the treatment of a vascular prosthesis, wherein the prosthesis is provided with an active substance ... 09/01/05 - 20050192664 - Controlled release endoprosthetic device The invention relates to improved drug-delivery endoprosthetic device for insertion at a vascular site via catheter placement at the site, comprising: (a) a structural member into the upper and/or lower surface of which one or more micro-deepenings are engraved and/or on which a polymer member is carried, for co-expansion with ... 08/18/05 - 20050182485 - Local vascular delivery of cladribine in combination with rapamycin to prevent restenosis following vascular injury Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed ... 08/11/05 - 20050177226 - Stents, stenting systems, and related methods for agent delivery A stenting system for insertion into the lumen of a body duct or vessel for delivering a therapeutic agent to a treatment site on the duct or vessel. The stenting system includes an a tubular stent member having a lumen there through to allow the passage of material, an outer ... 08/11/05 - 20050177225 - Medical implants and anti-scarring agents Implants are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. The agent may be any suitable anti-scarring agent, e.g., a cell cycle inhibitor, and may be used in conjunction with a second pharmaceutical agent, ... 08/04/05 - 20050171600 - Heparin stent There is provided a medical device adapted for insertion into a human or animal body, characterised in that its exterior surface is coated with (1) an inner first layer of a biocompatible carrier comprising a sulphated glycosaminoglycan and providing sustained release of a biologically active agent dissolved or dispersed therein; ... 07/28/05 - 20050165476 - Vascular grafts with amphiphilic block copolymer coatings One aspect of the invention relates to a graft, a surface of which is coated with an amphiphilic block copolymer that includes both hydrophobic and hydrophilic polymer chains. An amphiphilic block copolymer coating according to the invention can serve as a carrier for a very broad range of drugs, possibly ... 07/21/05 - 20050159809 - Implantable medical devices for treating or preventing restenosis Implantable medical devices having anti-restenotic antioxidants are disclosed. The anti-restenotic medical devices include stents and vascular grafts. Intravascular stents are preferred medical devices. The preferred anti-restenotic antioxidant is probucol. The medical devices can have coatings that include a polymer matrix. Related methods of treating or inhibiting restenosis using the Implantable ... 07/14/05 - 20050154454 - Intravascular devices and fibrosis-inducing agents Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices ... 07/14/05 - 20050154453 - Intravascular devices and fibrosis-inducing agents Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices ... 07/14/05 - 20050154452 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain isoflavonoid, are disclosed. The anti-restenotic isoflavonoid is phenoxodiol, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred ... 07/14/05 - 20050154451 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly certain protein farnesyl transferase inhibitors, are disclosed. The anti-restenotic protein farnesyl transferase inhibitors are tipifarnib, lonafarnib, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medial devices include stents, catheters, micro-particles, probes and ... 07/14/05 - 20050154450 - Stent reducing system and device A system for reducing the diameter of a stent comprises a stent contracting assembly and a fluid source. The assembly comprises a plurality of contracting members that define a diameter reduction chamber for receiving a stent. When the chamber is in a pre-reduction configuration the stent has a first diameter ... 07/07/05 - 20050149175 - Intravascular devices and fibrosis-inducing agents Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices ... 07/07/05 - 20050149174 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly certain PPAR agonists, are disclosed. The anti-restenotic PPAR agonists are netoglitazone, tesaglitazar, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents ... 07/07/05 - 20050149173 - Intravascular devices and fibrosis-inducing agents Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices ... 06/30/05 - 20050143808 - Coating for implantable medical devices An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol) polymer. The coating can also include a drug. ... 06/23/05 - 20050137684 - Stent with therapeutically active drug coated thereon Delivery of a Janus Kinase 3 (JAK3) inhibitor locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent ... 06/23/05 - 20050137683 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain endothelin receptor inhibitor, are disclosed. The anti-restenotic endothelin receptor inhibitor is atrasentan, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. ... 06/16/05 - 20050131532 - Apparatus and methods for controlled substance delivery from implanted prostheses The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention provides luminal prostheses which allow for a programmed and controlled substance delivery protocols for a variety of purposes. The prostheses comprise a scaffold which is ... 06/09/05 - 20050125054 - Devices delivering therapeutic agents and methods regarding the same Devices and methods for reducing, inhibiting, or treating restenosis and hyperplasia after intravascular intervention are provided. In particular, the present invention provides luminal prostheses which allow for sustained or controlled release of at least one therapeutic capable agent with increased efficacy to selected locations within a patient's vasculature to reduce ... ### FreshPatents.com Support |