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Chemistry: Natural Resins Or Derivatives; Peptides Or Proteins; Lignins Or Reaction Products Thereof > Proteins, I.e., More Than 100 Amino Acid Residues Proteins, I.e., More Than 100 Amino Acid ResiduesProteins, I.e., More Than 100 Amino Acid Residues patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/18/07 - 20070015909 - Adiponectin variants Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting ... 01/18/07 - 20070015908 - 123 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 01/18/07 - 20070015907 - Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a ... 01/18/07 - 20070015906 - Novel essential fungal polynucleotides, polypeptides, and methods of use The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening. ... 01/11/07 - 20070010658 - Trimeric binding proteins for trimeric cytokines The present invention pertains to the provision of trimeric binding units which bind to trimeric cytokines. In particular there is provided a trimeric polypeptide comprising a trimerising domain and three monomers with binding members capable of binding a trimeric cytokine. Preferably, the trimeric binding units bind in a manner such ... 01/11/07 - 20070010657 - Cytoplasmic dynein heavy chain 1 genes, expression products, non-human animal model uses in human neurological diseases A non-human animal model is provided, particularly a mouse model for movement hyperactivity, excitoxicity disorders (e.g. myoclonic cramping) and neurodegeneration, in which modified cytoplasmic dynein heavy chain1 is expressed. Modified human and mouse cytoplasmic dynein heavy chain1 proteins and nucleic adds are also provided, including the corresponding recombinant proteins. The ... 12/21/06 - 20060287504 - Universal procedure for refolding recombinant proteins A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The ... 12/21/06 - 20060287503 - Retinoid x receptor-interacting polypeptides and related molecules and methods Disclosed is purified DNA encoding retinoid X receptor-interacting proteins and methods for producing RXR-interacting proteins expressed from such DNA. ... 12/21/06 - 20060287502 - C3b/c4b complement receptor-like molecules and uses thereof Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides. ... 12/21/06 - 20060287501 - Soluble truncated polypeptides of the nogo-a protein The present invention refers to an isolated truncated Nogo-A polypeptide that corresponds to a truncated form of the Nogo-A protein consisting of the amino acids 174 to 940 of the full length protein of rat Nogo-A or of the amino acids 246 to 966 of the human full length Nogo-A ... 12/14/06 - 20060281902 - Human signal peptide-containing proteins The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP. ... 12/14/06 - 20060281901 - Method for the production of amyloid-beta peptide using ubiquitin The method for the production of amyloid-β peptide using ubiquitin as a fusion partner according to the present invention overcomes such problems of chemical methods for synthesizing amyloid-β peptide as low yield and high production cost, and can be effectively used for producing amyloid-β peptide in a high yield. ... 12/14/06 - 20060281900 - Lepidoptera voltage-gated calcium channels Novel nucleic acid sequences encoding lepidoptera calcium channel subunits, and recombinant expressions and host cells comprising the same are disclosed. Isolated lepidoptera calcium channel subunits, host cells expressing a lepidoptera calcium channel subunits, methods of producing the lepidoptera calcium channel subunits and antibodies specific for the lepidoptera calcium channel subunits ... 12/14/06 - 20060281899 - Mutants of biotin binding protein The present invention relates to new mutants of biotin binding proteins with improved properties, e.g., thermally stabilized compared to wild type proteins. Proteins, which bind biotin include chicken avidin and bacterial streptavidin, other poultry avidins, such as avidin proteins isolated from the duck, goose, ostrich and turkey, and chicken avidin-related ... 12/07/06 - 20060276631 - Antibody against a mast cell surface antigen A mast cell surface antigen, DNA thereof and an antibody against the antigen are provided. The amino acid sequence of this mast cell surface antigen is the translation of the coding region of its DNA. The base sequence of this DNA has been clarified in the following manner. Namely, mast ... 12/07/06 - 20060276630 - Method for detecting protein crystal, apparatus for detecting protein crystal and program for detecting protein crystal It is an object of the present invention to provide a protein crystal detection method, protein crystal detection apparatus, and protein crystal detection program with which protein crystals can be efficiently detected at a high reliability. To detect protein crystals with the present invention, an observed image obtained by observing ... 12/07/06 - 20060276629 - Purification and characterization of soluble human hla proteins The present invention relates generally to the production and use of functionally active soluble HLA molecules that are isolated and purified substantially away from other proteins, and methods of purifying same. ... 11/30/06 - 20060270836 - Eergamma peptide fragment complexes and uses thereof in drug discovery The present invention includes a method for the identification of novel compounds that interact and stabilize the ligand binding domain of ERRγ, a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands and the identification of novel biologically-active compounds that have an effect on ... 11/30/06 - 20060270835 - Diagnosis and treatment of alzheimer disease The present invention generally features therapeutic and diagnostic compositions and methods for increasing or decreasing the binding of a lysozyme polypeptide to a Treponema pallidum P17 polypeptide (Tp17) or a Tp17-like polypeptide. More particularly, the invention relates to compositions and methods for detecting, treating, or preventing a pathogen infection or ... 11/30/06 - 20060270834 - Vhl peptide Intractable neuronal diseases are treated by inducing differentiation of neural stem cells into neurons without accompanying a risk such as cytotoxicity and infection. Intractable neuronal diseases, such as Parkinson's disease, cerebral infarction, Alzheimer's disease, spinal cord injury, brain contusion, amyotropic lateral sclerosis, Huntington's disease, malignant tumor, and the like, are ... 11/30/06 - 20060270833 - Peptide complex A complex comprising at least one heat shock protein (HSP) and at least one peptide selected from the group consisting of R1-QXRAA-R2 with R1=peptide with 1-10 amino acids R2=peptide with 1-10 amino acids X=K or R GFFYTPK (insulin 23-29) SEQ ID No 1 GFFYTPKT (insulin 23-30) SEQ ID No 2 ... 11/23/06 - 20060264615 - Cytokine polypeptides and nucleic acids New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic acids, methods of making the polypeptides and nucleic acid, antibodies to the polypeptides, and methods of using the polypeptides and nucleic acids are provided. Integrated systems ... 11/23/06 - 20060264614 - T24 antigen for immunodiagnosis of taenia solium cysticercosis The present disclosure relates to T24 nucleic acid sequences, amino acid sequences, and antibodies. Methods for detecting and diagnosing Taenia solium infection in a subject using the T24 sequences and specific binding agents are also disclosed. The T24 sequences disclosed herein can be formulated into a pharmaceutical composition for administration ... 11/23/06 - 20060264613 - Polypeptides and methods for making the same An isolated protein having at least 90% homology with the dimeric protein having the following amino acid sequence (I) with the proviso that at the C-terminal end of the monomeric forms, 2 to 10 amino acid distance from Z2, a Cys is present for forming the dimeric or multimeric protein, ... 11/23/06 - 20060264612 - Optimised protein synthesis The invention concerns a method for the optimized production of proteins in an in vitro or in vivo expression system and reagents suitable therefor. ... 11/23/06 - 20060264611 - Pancreatic islet transcription factor and uses thereof The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes. ... 11/23/06 - 20060264610 - Protein complexes of the tip60 transcriptional activator protein The present invention relates to the TIP60-transcriptional activator protein complex, which is a part of the beta-amyloid precursor protein (APP) processing pathway, component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complexes. The present invention also relates to methods for use ... 11/23/06 - 20060264609 - Use of heat shock proteins The present invention relates to a fragment of heat shock protein that can increase the level of one or more cytokines and/or one or more CC chemokines and/or NO produced by a cell, above that caused by the corresponding full length heat shock protein. The invention also relates to the ... 11/16/06 - 20060258849 - Nucleic acids and proteins from streptococcus groups a & b The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics. ... 11/16/06 - 20060258848 - Human antipneumococcal antibodies from non-human animals The invention described herein provides human antibodies produced in non-human animals that specifically bind to Streptococcus pneumoniae capsular polysaccharide (PPS-3). The invention further provides methods for making the antibodies in a non-human animal and for expressing the antibodies in cells including hybridomas and recombinant host cell systems. Kits and pharmaceutical ... 11/16/06 - 20060258847 - Method of preparing botulinum neurotoxin type a light chain The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentially of amino acid residues 1 through 425 of the botulinum toxin light chain type A. A method of screening inhibitors is ... 11/16/06 - 20060258846 - Crystal structure of snap-25 in complex with botulinum neurotoxin and uses thereof The present invention provides a crystallized form of the E224Q Y336F mutant of the light chain of botulinum neurotoxin serotype A (BoNT/A) protein as well as the atomic structure of this mutant protein. The present invention also provides crystals of the E224 Y336F mutant of the BoNT/A light chain in ... 11/16/06 - 20060258845 - Novel purified polypeptides from staphylococcus aureus The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 11/16/06 - 20060258844 - Algae fluorescence protein dry powder structure and manufacturing method thereof This present invention is related to an algae fluorescence protein dry powder structure and the manufacturing method thereof. The algae fluorescence protein dry powder structure includes a substrate and a mixture layer, which is coated around the substrate. The mixture layer consists of polysaccharide and algae fluorescence protein, wherein the ... 11/16/06 - 20060258843 - Post-translational modifications and clostridial neurotoxins The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain. ... 11/16/06 - 20060258842 - Human anthrax toxin neutralizing monoclonal antibodies and methods of use thereof The invention fully humanized monoclonal antibodies that neutralize Bacillus anthracis. Also provided are methods of treating or preventing a Bacillus anthracis infection. The invention also provides methods of passive vaccination of a subject against Bacillus anthracis. ... 11/16/06 - 20060258841 - Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also ... 11/16/06 - 20060258840 - Peroxisome proliferator-activated receptor The present invention features mutated forms of PPAR ligand binding domain polypeptides that: (1) bind a partial PPAR agonist; and (2) is bound or activated by a full PPAR agonist to a lesser extent than the wild-type receptor. The mutated ligand binding domain contains an amino acid sequence wherein one ... 11/09/06 - 20060252918 - Use of hepatitis virus (hcv) p7 protein The present invention relates to the use of hepatitis C virus (HCV) p7 protein, and particularly but not exclusively, to its use in rationalised drug design and as a screen for antiviral therapeutic agents. ... 11/02/06 - 20060247421 - Liver x receptor alpha splicing mutant protein, gene thereof and utilization of the same The present invention provides a liver X receptor α splicing mutant protein which is an isoform of a liver X receptor α, and which comprises at least an amino acid sequence encoded by exon 5 of a liver X receptor α gene, a gene thereof, and use thereof, and these ... 11/02/06 - 20060247420 - Immune cell recptor ligand and immune cell receptor The present invention relates, in general, to immune cell receptor ligands and immune cell receptors. More specifically, the invention relates to an NKG2D immunoreceptor ligand and to an immune cell receptor having the same C-type lectin structure as the NKG2D receptor, and to nucleic acid sequences encoding same. ... 11/02/06 - 20060247419 - Translocation dependent complementation for drug screening The present invention relates to various uses of complementing proteins protein fragments to discover chemical compounds or drugs interfering with protein translocation/redistribution and/or protein interactions. The invention takes advantage of the fact that many interacting proteins reside in separate and distinct locations prior to the activation of the signaling pathways ... 11/02/06 - 20060247418 - Gfp fusion proteins and their use The present invention provides fusion proteins including a green fluorescent protein inserted into the internal amino acid sequence of a Gαs protein and further provides method of using the fusion protein construct to follow activation of a G-protein receptor by a candidate drug. ... 10/26/06 - 20060241285 - Crystals and structure of synagis fab The present invention provides machine readable media embedded with the three-dimensional atomic structure coordinates of Synagis Fab, and subsets thereof, and methods of using them. ... 10/26/06 - 20060241284 - Transmembrane protein amigo and uses thereof The present invention provides methods and compositions relating to vertebrate AMIGO, AMIGO2, AMIGO3, collectively vertebrate AMIGO polypeptides, related nucleic acids, and polypeptide domains thereof having vertebrate AMIGO-specific structure and activity, and modulators of vertebrate AMIGO function. ... 10/19/06 - 20060235204 - Bmp-2 variants with improved properties The invention relates to variants of BMP-2 with improved properties and methods for their use. ... 10/19/06 - 20060235203 - Mn gene and protein Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN gene expression. Also disclosed are methods to treat pre-neoplastic/neoplastic disease involving the ... 10/19/06 - 20060235202 - Novel galanin receptor The present invention is directed to a novel receptor for galanin which has been designated as galanin receptor 2. The invention encompasses both the receptor protein as well as nucleic acids encoding the protein. In addition, the present invention is directed to methods and compositions which rely upon either GAL-R2 ... 10/19/06 - 20060235201 - Enduring t cell response The present invention provides a trimeric polypeptide construct, wherein each monomer of the trimeric polypeptide construct consists of two or three domains, and wherein the first domain is the extracellular domain of 4-1BBL or (a) part(s) thereof, the second domain consists of an antigen-interaction-site which is located N-terminally of the ... 10/19/06 - 20060235200 - Mutagenesis of aspergillus fungi and identification of genes essential for growth The present invention is directed to polynucleotides encoding proteins Essential For the Growth (EFG) of filaments fungi. The invention also deals with namely polypeptides encoded by said polynuctleotides, screening assays for identifying compounds capable of inhibiting said EFG proteins activities pharmaceutical or phytosanitary compositions comprising such compounds. ... 10/12/06 - 20060229435 - Lymphocyte homing receptors DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions. ... 10/12/06 - 20060229434 - Low-molecular weight peptides inhibiting ion channel activity It is intended to provide novel polypeptides which specifically inhibit the activity of a mechano-sensitive channel; and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing these polypeptides or salts thereof. The above objects can be achieved by using polypeptides having amino acid sequences represented by SEQ ID NO:I (TVPOO3), ... 09/28/06 - 20060217535 - Hemipteran muscarinic receptor Novel nucleic acid sequences encoding hemipteran muscarinic receptors, and recombinant expressions and host cells comprising the same are disclosed. Isolated hemipteran muscarinic receptors, host cells expressing hemipteran muscarinic receptors, methods of producing the hemipteran muscarinic receptors and antibodies specific for hemipteran muscarinic receptors are also disclosed. Methods of identifying modulators ... 09/21/06 - 20060211848 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses The invention relates to Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, ... 09/21/06 - 20060211847 - Drive device The invention relates to a drive device, particularly for doors, garage doors, etc., comprising a guide device, particularly a rail or guide rail, extending in movement direction of the door. The invention is characterised in that the feed means comprises a first insert body which can be plugged at the ... 09/14/06 - 20060205925 - Streptoccal inhibitor of complement-mediated lysis, protein sic A protein from Streptococcus pyogenes, serotype M1 has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by interacting with the plasma proteins clusterin, and members of the cystatin protein super family such as histidine rich glycoprotein (HRG). The protein, ... 09/14/06 - 20060205924 - Spliced variants of lgr6 The present invention provides Leucine-Rich Repeat-Containing G-Protein Coupled Receptor-6 (LGR6-Vs) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing LGR6-SVs polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of ... 09/07/06 - 20060199947 - Canine and feline b7-1 nucleic acid molecules The present invention relates to B7 proteins; to B7 nucleic acid molecules, including those that encode such B7 proteins; to antibodies raised against such B7 proteins; and to therapeutic compounds that regulate B7 function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, ... 09/07/06 - 20060199946 - Apoptosis inducing agent and method for inducing apoptosis An object of the present invention is to provide a novel means for stably and surely inducing cell apoptosis using the c-myc gene as a target. The present invention relates to an apoptosis-inducing agent containing a protein that interacts with an FBP protein or a polynucleotide encoding the protein as ... 08/31/06 - 20060194950 - Mutant protein The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for ... 08/31/06 - 20060194949 - Structure of the farnesoid x receptor ligand binding domain and methods of use therefor The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The ... 08/24/06 - 20060189792 - Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies The invention provides (Neisseria meningitidis) BASB030 polypeptides and polynucleotides encoding BASB030 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are antibodies, diagnostic, prophylactic and therapeutic uses thereof. ... 08/24/06 - 20060189791 - Recombinant expression of streptococcus pyogenes cysteine protease and immunogenic compositions thereof The present invention generally relates to the fields of molecular biology, clinical bacteriology and protein folding. More particularly, the invention relates to methods for recombinantly expressing a soluble mature Streptococcus pyogenesexotoxin B (SpeB) polypeptide in a host cell. ... 08/24/06 - 20060189790 - Removal of lipopolysaccharides from protein-lipopolysaccharide complexes by non flammable solvents. During the production of recombinant proteins from gram negative bacteria, lipopolysaccharides (LPS, endotoxin) are released along with the protein of interest. In many instances, LPS will copurify with the target protein due to specific or non-specific protein-ILPS interactions. We have investigated the ability of alkanediols to effect the separation of ... 08/17/06 - 20060183886 - Ligands to enhance cellular uptake of biomolecules The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payload” to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway. ... 08/17/06 - 20060183885 - Protein forming complex with c-fos protein, nucleic acid encoding the same and method of using the same Proteins that interact with c-Fos, nucleic acids encoding them and inhibitors utilizing them as well as methods for detecting an interaction and screening methods utilizing a protein that interacts with c-Fos are provided. Comprehensive analysis of transcription control factor complexes in a mouse brain cDNA library with c-Fos as a ... 08/10/06 - 20060178504 - Eotaxin: eosinophil chemotactic cytokine A chemoattractant protein called “eotaxin” is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that inhibit or otherwise hinder the production, release or activity of eotaxin may be used therapeutically in the treatment of asthma and other inflammatory ... 08/10/06 - 20060178503 - Antibody to an integrin heterodimer and/or a subunit thereof A recombinant or isolated integrin heterodimer comprising a novel subunit α10 in association with a subunit β is described. The α10 integrin may be purified from bovine chondrocytes on a collagen-type-II affinity column. The integrin or the subunit of α10 can be used as a marker or target of all ... 08/10/06 - 20060178502 - Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided. ... 08/03/06 - 20060173166 - Protein lattice Protein lattice (1) having a regular structure with a repeating unit repeating in three dimensions may have many uses, for example to support an array of macromolecular entities for x-ray crystallography. The repeating unit comprises protein protomers (2) which each comprise at least two monomers (5, 6) fused together. The ... 08/03/06 - 20060173165 - Systems for expressing toxic proteins, vectors and method of method of producing toxic proteins The present invention relates to a system for expressing toxic proteins, to an expression vector comprising this system, to a prokaryotic cell transformed with this system, and also to a method for synthesizing a toxic protein using this expression system. The expression system of the invention is characterized in that ... 08/03/06 - 20060173164 - Staphylococcal nuclease fusion proteins for the produciton of recombinant peptides Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier protein acts to promote the over-expression of the peptide-protein fusion in the form of inclusion bodies, which minimizes in-cell proteolysis of desired peptides. ... 07/27/06 - 20060167229 - Biologically active peptide conjugates Thirty substantially pure and biologically active peptides are disclosed. Nucleic acids that have sequences coding for the biologically active peptides and pharmaceutical formulations produced therefrom are also disclosed. Methods for altering the biological activity of the peptides are disclosed. ... 07/27/06 - 20060167228 - Sequences from an endosymbiont and their uses rDNA corresponding to an endosymbiotic bacteria associated with Ecteinascidia turbinata has been identified. The bacterium appears to be responsible for the biosynthesis of ecteinascidin compounds. The 16S rDNA sequence corresponding to Candidatus Endoecteinascidia frumentensis SEQ ID NO: 1 has been deposited in GeneBank with the accession number AY054370. ... 07/27/06 - 20060167227 - Truncated tau proteins Described are novel N- and C-terminally double truncated tau molecules, (“type IA, IB, IIA and IIB tau molecules”) as well as methods for providing these molecules, both from recombinant and biological sources. Moreover, screening methods using these molecules in connection with Alzheimer's diagnosis and therapy are provided. ... 07/27/06 - 20060167226 - Mutations of voltage-gated ion channnels that allow them to express a voltage-independent phenotype and an improved method to use the same The subject invention includes mutant voltage-gated ion channels that are open over a wide range of potential differences across membranes. The present invention also includes methods of use such mutant voltage-gated ion channels in cells with highly negative potential differences across their membranes. One preferred mutant voltage-gated ion channel is ... 07/27/06 - 20060167225 - Novel fluorescent protein from aequorea coerulscens and methods for using the same The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from Aequorea coerulscens and fluorescent and non-fluorescent mutants and derivatives thereof, as well as peptides and proteins encoded by these nucleic acid compositions. The subject protein and nucleic acid compositions of the present invention are colored ... 07/20/06 - 20060160992 - Method of identifying cells expressing a protein having pre-b cell growth-supporting ability A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability or a part of it. A method for producing said novel membrane protein polypeptide by preparing transformants by transforming a ... 07/20/06 - 20060160991 - Genes and polypeptides relating to prostate cancers The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes ... 07/20/06 - 20060160990 - Fluorescent protein and chromoprotein It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property. ... 07/13/06 - 20060155115 - Multivalent t cell receptor complexes The present invention relates to a synthetic multivalent T cell receptor complex for binding to a MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell ... 07/13/06 - 20060155114 - Protein complex, process for producing the same and use thereof It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the protein complex in a biosensor, an immobilized enzyme and so on. A protein complex comprising a polyhedral ... 07/13/06 - 20060155113 - Replication protein This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its ... 07/13/06 - 20060155112 - Fibrr-shaping peptides capable of interacting with self-assembling peptides The present invention relates to a fibre-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fibre-shaping peptides of the present invention. ... 07/13/06 - 20060155111 - Novel genes and their use in the modulation of obesity, diabetes and energy imbalance The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for ... 07/06/06 - 20060149038 - Pro211 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 07/06/06 - 20060149037 - Cupredoxin derived transport agents and methods of use thereof The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer. ... 07/06/06 - 20060149036 - Composition and method for self-assembly and mineralizatin of peptide amphiphiles The present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a solution comprised of a positively or negatively charged peptide-amphiphile and a like signed ion from the mineral. Mixing this solution with a second solution containing ... 06/29/06 - 20060142548 - Methods of identifying and designing cell surface receptor inhibitors The methods described herein provide for ways of modulating, specifically inhibiting, integrin activation. The methods include identifying compounds such as naturally occurring and non-naturally occurring polypeptides and small molecules which bind to the βA domain of an integrin thus mimicking the contact between the CD loop with βA domain. Contacting ... 06/29/06 - 20060142547 - Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered thermoreceptor belonging to the Transient Receptor Potential (TRP) family of non-selective cation channels that participates in thermosensation and pain. This receptor, designated ANKTMI, ... 06/22/06 - 20060135751 - Human n-type calcium channel isoform and uses thereof The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hα1B+SFVG channel. Also included are human N-type calcium channel hα1B+SFVG subunit inhibitors which ... 06/22/06 - 20060135750 - Novel protein and gene encoding the same With the object of providing a novel protein expression of which is specifically elevated in abnormal cells or abnormal tissue, and also providing a diagnostic method and diagnostic kit for diseases involving elevated expression of a gene encoding that protein, along with a screening method and screening kit for substances ... 06/22/06 - 20060135749 - Cd47 partal peptdie and anti-shps-1 monoclonal antibody A CD47 partial peptide which has an amino acid sequence constituting an extracellular region having an immunoglobulin-like structure of a CD47 protein, which is specifically bound to an N-terminal immunoglobulin-like structure of a dephosphorylation substrate protein SHPS-1 of an SH2 domain-containing protein, and which can act on a function of ... 06/22/06 - 20060135748 - Antimicrobial peptide isolated from halocynthia aurantium The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong ... 06/15/06 - 20060128945 - Reaction process A reaction process, characterised by the step of introducing reaction components to a medium, wherein at least one of the reaction components has a different flow rate from the other reaction component(s) through the medium, so that a moving reaction phase is formed which causes reaction products. ... 06/15/06 - 20060128944 - Molecular linkers suitable for crystallization and structural analysis of molecules of interest, method of using same, and methods of purifying g protein-coupled receptors A method of crystallizing a molecule-of-interest is disclosed. The method comprises (a) contacting molecules of the molecule-of-interest with at least one type of heterologous molecular linker being capable of interlinking at least two molecules of said molecule-of-interest to thereby form a crystallizable molecular complex of defined geometry; and (b) subjecting ... 06/08/06 - 20060122373 - Delta3, fthma-070, tango85, tango77, spoil,neokine, tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, ... 06/08/06 - 20060122372 - Polymorphisms in the human genes for oct1 and their use in diagnostic and therapeutic applications The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or ... 06/01/06 - 20060116506 - Tenebrio antifreeze proteins A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, Tenebrio molitor. Internal sequencing of the proteins, leading to cDNA cloning and production of the protein in bacteria has ... 06/01/06 - 20060116505 - Glucose and/or fructose transporter naglt1 and its gene The present invention provides a novel glucose and/or fructose transporter involved in renal diabetes, its gene, their variant, and their use. The glucose and/or fructose transporter of the present invention and its gene are a glucose and/or fructose transporter involved in renal diabetes and its gene, the protein and the ... 06/01/06 - 20060116504 - Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, ... 05/25/06 - 20060111558 - Recombinant infectious laryngotracheitis virus and uses thereof The present invention provides a recombinant, attenuated infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the glycoprotein gG gene. This attenuated virus is useful as a vaccine against infectious laryngotracheitis virus. The present invention also provides a recombinant, attenuated infectious laryngotracheitis virus comprising the ... 05/25/06 - 20060111557 - Water soluble toxin produced by pfiesteria species An isolated and purified Pfiesteria toxin having the NMR spectra given in FIG. 1 herein is described. The toxin may be produced by (a) culturing a Pfiesteria species in a growth media to produce Pfiesteria toxin therein; (b) separating a first fraction of organic compounds including said Pfiesteria toxin from ... 05/25/06 - 20060111556 - Preventives/remedies for neurodegenerative diseases A compound or its salts inhibiting the activity of the protein of the present invention, a compound inhibiting the expression of a gene for the protein, the antisense polynucleotide of the present invention, the antibody of the present invention, and the like can be used as prophylactic/therapeutic agents for neurodegenerative ... 05/25/06 - 20060111555 - Protein crystallisation method A method for the crystallization of macromolecules in a three-phase system using a vessel containing a lower aqueous phase, a middle phase and an upper hydrophobic phase having a lower density than that of the lower aqueous phase, wherein an aqueous solution of the macromolecules is added to the middle ... 05/25/06 - 20060111554 - Method, computing routine, device for predicting properties of mhc/peptide complexes, and data and peptides produced therefrom The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for ... 05/18/06 - 20060106202 - Peripheral-type benzodiazepine receptor associated proteins, cloning, expression and methods of use The present invention relates to nucleic acids encoding PBR-associated proteins (PAPs) and methods for use in producing PAPs and methods of using PAPs. In this study we have identified proteins (PAPs) that interact with PBR protein by a yeast two-hybrid system. We used PBR as bait to screen a mouse ... 05/18/06 - 20060106201 - Novel hemopoietin receptor protein, nr12 A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was ... 05/18/06 - 20060106200 - Soluble, functional apoptotic protease-activating factor 1 fragments The structure of a soluble, functional fragment of human Apaf-1 protein having ADP bound thereto is disclosed. The invention includes such soluble, functional fragments of human Apaf-1 and other metazoan Apaf-1 homologs. Also included in the invention are methods of making such fragments and methods of using them, for example ... 05/18/06 - 20060106199 - Streptavidin-binding peptide The invention relates to novel streptavidin binding peptides. ... 05/11/06 - 20060100418 - Cultured xenopus cell line expressing mutated apc Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell ... 05/11/06 - 20060100417 - Isolated human transporter proteins nucleic acid molecules encoding human transporter proteins and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying ... 05/11/06 - 20060100416 - Novel substitution mutant receptors and their use in an nuclear receptor-based inducible gene expression system This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression ... 05/04/06 - 20060094863 - Cat kidney disease marker In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast ... 05/04/06 - 20060094862 - Specificity exchangers that redirect antibodies to a pathogen Specificity exchangers and methods of making and using specificity exchangers are disclosed. Specificity exchangers are useful for preventing and treating human diseases including cancer and those resulting from pathogens such as bacteria, yeast, parasites, fungus, viruses, and the like. More specifically, specificity exchangers can redirect existing antibodies in a subject ... 04/27/06 - 20060089490 - Survival motor neuron (smn) gene: a gene for spinal muscular atrophy The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding ... 04/20/06 - 20060084792 - Versatile platform for nanotechnology based on circular permutations of chaperonin protein The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the folded modified chaperonin polypeptide. In the modified chaperonin polypeptide, the naturally-occurring N-terminal ... 04/20/06 - 20060084791 - Purified polypeptide, isolated nucleic acids encoding said polypeptide, vectors and use thereof The present invention relates to a purified polypeptide, which is capable of mediating infection of a cell, by use of the polytropicixenotropic receptor encoded by the Rmc1 locus from a NIH Swiss inbred NFS/N mouse for entry, and unable of mediating infection of a cell by use of a human ... 04/20/06 - 20060084790 - P-rex1, a ptdins (3,4,5) p3-g-beta-gamma-regulated guanine-nucleotide exchange factor for rac A novel protein useful as an anti-inflammatory target is described. Methods of making the protein, and use of the protein in assays for identification of anti-inflammatory agents are described. Methods of making knock-out mice for the gene encoding the protein are also desired. ... 04/13/06 - 20060079670 - 98 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 04/13/06 - 20060079669 - Crystal structures of nh3-dependent nad synthetases The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 04/13/06 - 20060079668 - Junctional adhesion molecule splice variants This invention provides splice variants of human junctional adhesion molecules (huJAM) and polynucleotides which encode the huJAM splice variants. The invention further provides methods using the molecules of the invention for treating wound healing, cancer, inflammatory disorders, immune system disorders and cardiovascular disorder. ... 04/06/06 - 20060074221 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060074220 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 03/30/06 - 20060069243 - Ovary-specific genes and proteins Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which ... 03/30/06 - 20060069242 - Neurotrophic factor receptor There is disclosed a novel mammalian receptor protein designated GFRα-4 and the nucleic acid sequence encoding therefore; an isolated and purified GFR α-4 receptor polypeptide comprising SEQ ID NO: 9. Also provided is an expression vector comprising the nucleic acid sequence and host cells transformed or transfected with the vector. ... 03/30/06 - 20060069241 - Endocytosing delivery vehicle for targeting drugs and antibodies to prostate and other tissues A chimeric transmembrane protein comprising a membrane-spanning polypeptide and an internalization motif of the sequence MXXXL, where X is any amino acid. The chimeric protein can be expressed on the surface of a cell and internalized. Polynucleotides and expression vectors encoding chimeric transmembrane proteins are also provided. Expression of chimeric ... 03/30/06 - 20060069240 - Identification and characterization of reflectin proteins from squid reflective tissues A family of reflectin proteins is identified herein that is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins are encoded by at least six genes in three subfamilies and have no reported homologues outside of squids. Reflectins possess 5 repeating domains, that are ... 03/30/06 - 20060069239 - Epididymis-specific gene as potential contraceptive target Isolated splice variant polypeptides from the family of human epididymis-specific receptors called HE6, and related polypeptides from mouse (ME6) and rat (RE6), are described. Also described are isolated polynucleotides encoding the polypeptides, and fragments and variants of the polypeptides and polynucleotides. The polypeptides are involved in maturation of sperm during ... 03/23/06 - 20060063919 - Self-assembling-peptide-based structures and processes for controlling the self-assembly of such structures The thermodynamics of self-assembling peptides may be altered to produce different morphologies. By altering environmental factors, initiation and propagation of self-assembly processes may be altered, thereby consequently altering the morphology of the resultant structure. ... 03/16/06 - 20060058510 - Anticalins The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus ... 03/16/06 - 20060058509 - Refolding of membrane proteins In a method for production of membrane receptors folded into their native structure, first, receptors solubilized in a first detergent are provided. To induce folding of receptors into their native form, the first detergent is exchanged for a second detergent. Both for the first and for the second detergent, examples ... 03/16/06 - 20060058508 - Novel functional peptide nucleic acid and process for producing the same (wherein R represents H, a functional molecule or a protecting group, and n represents an integer of 1 to 11). ... 03/16/06 - 20060058507 - Krib polynucleotides and polypeptides and uses thereof in the treatment of metabolic disorders The present invention relates to the field of metabolic research. KRIB polypeptides have been identified that are beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic disorders. These metabolic disorders include hyperlipidemia, atherosclerosis, diabetes, and hypertension. ... 03/16/06 - 20060058506 - Synthetic anti-candida albicans oligosaccharide based vaccines The present invention provides methods of making and using immunogenic oligosaccharide compositions comprising native O-linked and S-linked oligosaccharides coupled to a protein carrier, wherein the resultant conjugate elicits a protectively immunogenic response. These compositions may be useful in vaccines against pathogenic Candida species. ... 03/16/06 - 20060058505 - Nucleic acid and polypeptide linked to breast cancer and uses therefor The present invention relates to an isolated domain of G3BP-2 that mediates binding between G3BP-2 and other proteins, and nucleic acids encoding same. The invention also relates to a method for diagnosing, treating and preventing breast cancer including the step of using a nucleic acid and/or encoded polypeptide for G3BP-2, ... 03/09/06 - 20060052584 - Human-derived bradeion proteins, dna coding for the proteins, and uses thereof A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it ... 03/09/06 - 20060052583 - Protein production Proteins may be made by genetically engineered microorganisms, the protein being stored in the form of inclusion bodies (IB). The proteins in the inclusion bodies are in an insoluble and inactive form. They may be dissolved using a solubilisation reagent (18), and the resulting solution diluted so that the proteins ... 03/02/06 - 20060047106 - Neisseria meningitdis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments, the invention relates to multivalent immunogenic compositions comprising five distinct Neisseria meningitidis inner core lipo-oligosaccharide epitope groups, wherein the multivalent compositions induce cross-reactive immune responses against Neisseria meningitidis ... 02/23/06 - 20060041108 - Renilla reniformis green fluorescent protein Green fluorescent protein (GFP) polypeptides from Renilla reniformis and Renilla kollikeri are disclosed. The amino acid sequence of R. reniformis GFP and back-translated nucleotide sequences of nucleic acids encoding the R. reniformis GFP are also disclosed. These isolated polypeptides, along with the pertinent amino acid and nucleotide sequence information, are ... 02/23/06 - 20060041107 - Mutants of streptococcal toxin a and methods of use This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins ... 02/23/06 - 20060041106 - Apo-3 polypeptide Novel polypeptides, designated Apo-3, which are capable of stimulating or inducing apoptosis are provided. Compositions including Apo-3 chimeras, nucleic acid encoding Apo-3, and antibodies to Apo-3 are also provided. ... 02/16/06 - 20060036079 - Surface protein of leptospira The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... 02/16/06 - 20060036078 - Fluorescent proteins The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified GFPs exhibit enhanced fluorescence relative to wtGFP when expressed in non-homologous ... 02/16/06 - 20060036077 - Gamma secretase substrates and in vitro assays The present invention features γ-secretase substrates and in vitro assays for measuring γ-secretase activity employing such substrates. The γ-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a β-CTF domain. A “β-CTF domain” is a polypeptide that can be cleaved by γ-secretase and ... 02/16/06 - 20060036076 - Metalloproteinase-binding proteins Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders. ... 02/16/06 - 20060036075 - Process for removing endogenous vitamin b12 and folate from albumin preparations Processes for removing endogenous Vitamin B12 and folate are provided. The albumin preparations produced by the process are suitable for use as reference control samples in assays for determining these analytes in a test sample. Kits and methods related to the albumin preparations are also provided. ... 02/16/06 - 20060036074 - Bromodomain protein Hupolybromo1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hupolybromo1 polypeptides and polynucleotides in diagnostic assays. ... 02/09/06 - 20060030694 - Notch-based fusion proteins and uses thereof This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. ... 02/02/06 - 20060025571 - Morphogen-induced dendritic growth Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In ... 02/02/06 - 20060025570 - Megakaryocyte stimulating factors Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided. ... 01/26/06 - 20060020115 - Nematode neuromuscular junction gaba receptors and methods related thereto The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA ... 01/26/06 - 20060020114 - Apo-2dcr Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided. ... 01/26/06 - 20060020113 - Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four ... 01/19/06 - 20060014932 - Purified and isolated protein zero related (pzr) and therapeutic and screening methods using same Isolated and purified proteins and nucleic acids including a novel member of the immunoglobulin super-family characterized as having SHP-2 binding activity and cell signaling activity and called protein zero related or PZR, and cDNA encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along ... 01/19/06 - 20060014931 - Novel promoter Disclosing a promoter of the protease MDTS9, which is induced by TGF-β, which is involved in the metabolism of extracellular matrix, and in which the expression of the gene thereof is elevated in renal failure model animals, which promoter is useful as a tool for screening an agent for treating ... 01/12/06 - 20060009620 - Protein structures and protein fibres This invention relates to protein fibre formation and in particular to methods of producing protein fibres to form a protein structure comprising a plurality of first polypeptide units arranged in a first polypeptide strand and a plurality of second polypeptide units arranged in a second polypeptide strand, the strands preferably ... 01/12/06 - 20060009619 - Ricin vaccine and methods of making and using thereof Disclosed herein are polypeptides and variants thereof comprising a polypeptide sequence having substantial identity to ricin A chain (RTA) that lack detectable N-glycosidase-rRNA activity or exhibit reduced N-glycosidase-rRNA activity as compared to controls and methods of making and using thereof. The polypeptides and variants have a greater solubility in aqueous ... 01/12/06 - 20060009618 - Expression receptors with 7 transmembrane domains in baculovirus-insect cell system The invention concerns the expression in a baculovirus-insect cell system of receptors with seven transmembrane domains, in particular receptors coupled to proteins (;, in particular olfactory receptors, under the transcriptional control of a promoter derived from the polyhedrin promoter by deletion of all or part of the region of said ... 01/05/06 - 20060004187 - Bk beta subunits of slo family potassium channels The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for ... 01/05/06 - 20060004186 - P. ariasi polypeptides, p. perniciosus polypeptides and methods of use Substantially purified salivary P. ariasi and P. perniciosus polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the P. ariasi and P. perniciosus polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, ... 12/29/05 - 20050288489 - Voltage-dependent calcium channel beta subunit functional core The present invention relates to crystallized forms of a voltage dependent calcium channel β subunit functional core, methods of producing and methods of utilizing the same. ... 12/29/05 - 20050288488 - Ah receptor cdna and genetically engineered cells for detecting agonists to the ah receptor Murine and human Ah receptor cDNAs are provided. These molecules can be used to generate large quantities of Ah-receptor protein. The Ah receptor can be inserted into cell systems such as yeast or mammalian, expressed, and used in assays to detect agonists to the Ah receptor. The Ah receptor inserted ... 12/29/05 - 20050288487 - Human mast cell-expressed membrane proteins Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein ... 12/22/05 - 20050282999 - Beta-amyloid peptide-binding proteins and polynucleotides encoding the same Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided. ... 12/15/05 - 20050277763 - Cytotoxic cyplasin of the sea hare, aplysia punctata, cdna cloning and expression of bioreactive recombinants Described is a nucleic acid coding for a protein called “cyplasin” that shows a preferential toxicity to autonomously growing mammalian cells. Cell death induced by this protein differs from both apoptosis and necrosis. An intracellular cell death which occurs when recombinantly preparing cyplasin in cell cultures can be avoided by ... 12/15/05 - 20050277762 - Semisynthetic protein-based site-directed probes for identification and inhibition of active sites, and methods therefor A C-terminally modified Ubiquitin (Ub) derivative) ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that irreversibly modifies a subset of Ub C-terminal hydrolases (UCHs) and Ub specific processing proteases (UBPs), is provided. [125I]-UbVS modifies 6 of the 17 known ... 12/15/05 - 20050277761 - Potassium channel interactors polypeptides and uses thereof The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been ... 12/08/05 - 20050272915 - Skrp, astray, string, vacm associated with metabolic control The present invention discloses novel uses for energy homeostasis regulating proteins and polynucleotides encoding these in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders. ... 11/24/05 - 20050261478 - Compositions and methods for regulating lymphocyte activation The present invention relates to regulation of lymphocyte activation. In particular, it relates to compositions and methods for regulating lymphocyte activation by selectively binding multiple cell surface antigens expressed by the same lymphocyte. ... 11/24/05 - 20050261477 - Pharmaceutical compositions and medical treatments comprising notch ligand proteins Provided is a Notch ligand protein or polypeptide comprising a Notch ligand DSL domain; 1 to 5 (but no more than 5) Notch ligand EGF repeat domains; optionally, all or part of a Notch ligand N-terminal domain; and optionally, one or more heterologous amino acid sequences. Also provided is a ... 11/24/05 - 20050261476 - Peptides for chlamydophila pneumoniae vaccine and diagnosis Peptides are disclosed that include SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, or a conservative variant or mimic thereof, wherein the conservative variant or mimic specifically binds an antibody that specifically binds SEQ ID NO: 1, SEQ ... 11/10/05 - 20050250933 - Peptide fragment of respiratory syncytial virus protein g, immunogenic agent, pharmaceutical composition containing it and preparation method A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence ... 11/03/05 - 20050245728 - Novel purified polypeptides from pseudomonas aeruginosa The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 11/03/05 - 20050245727 - Novel polypeptide scaffolds and use thereof Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ... 10/27/05 - 20050240009 - T-cell epitopes in staphylococcal enterotoxin b The present invention relates to the field of immunology. The invention identifies determinants on staphylococcal enterotoxin B (SEB) able to evoke an immune response. In particular the invention is concerned with the identification of epitopes for T-cells in SEB. The invention relates furthermore to T-cell epitope peptides derived from SEB ... 10/27/05 - 20050240008 - Novel protein, dna thereof and process for producing the same The present invention relates to a novel protein containing a peptide having a ligand activity to a G-protein copuled receptor protein; amides, esters, salts of the peptides; and drugs containing the same. ... 10/20/05 - 20050234223 - Histamine receptor h3 ordinary activity mutant and utilization thereof Internal domain 3 of seven transmembrane G protein-coupled receptors is important for G protein binding or receptor activity, and is well conserved. In H3 receptors, which are a type of G protein-coupled receptor, this region is also conserved in the same way. Therefore, as a result of using PCR to ... 10/20/05 - 20050234222 - Conjugate The present invention relates to a polypeptide comprising at least one alpha-helix having synthetically attached thereto a plurality of therapeutic or diagnostic moieties, wherein said therapeutic or diagnostic moieties may be the same or different and are spatially oriented on the polypeptide so as to minimise interactions between said moieties. ... 10/20/05 - 20050234221 - Il-17 receptor like molecules and uses thereof Novel IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor ... 10/13/05 - 20050228170 - B7-like molecules and uses thereof The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions ... 10/13/05 - 20050228169 - Polypeptide binding to human syntaxin 1a There is provided a polypeptide that binds to syntaxin-1a and comprises the amino acid sequence shown in SEQ ID NO: 1 in the Sequence Listing, or a polypeptide having a homology of at least approximately 90% to the amino acid sequence that binds to syntaxin-1a, a partial peptide thereof, and ... 10/06/05 - 20050222390 - Tumor-associated peptides binding to mhc-molecules The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide has the ability to bind to a molecule of the human major histocompatibility complex (MHC) class-I. The invention ... 10/06/05 - 20050222389 - Method for preparing modified polypeptides Methods for producing polypeptide with altered immunogenicity or improved stability properties are disclosed. The methods involve a) expressing a diversified population of nucleotide sequences encoding a polypeptide of interest, b) screening the polypeptides expressed in step a) for function, immunogenicity and/or stability, c) selecting functional polypeptides having altered immunogenicity and/or ... 10/06/05 - 20050222388 - Fusion protein of hiv regulatory/accessory proteins The invention relates to fusion proteins comprising the amino acid sequence of at least four HIV proteins selected from Vif, Vpr, Vpu, Rev, Tat and Nef or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV ... 10/06/05 - 20050222387 - Smac-peptides as therapeutics against cancer and autoimmune diseases The invention is directed to the use of Smac to sensitize different tumors and self-reactive immune cells to various pro-apoptosic stimuli, in that the cells subsequently undergo apoptosis. Therefore, Smac can be used as a compound for the manufacture of a medicament for the treatment of cancer and autoimmune diseases. ... 10/06/05 - 20050222386 - Biomolecule transduction motif sim-2-btm and the use thereof This invention is about a novel Biomolecule Transducton Motif (BTM), Sim-2 peptide, which has a potential to transduce many biological response modifiers effectively into the cytoplasm, intracellular organelles or nucleus of prokaryotic or eukaryotic cells in vivo and in vitro, and the related technological methods using Sim-2 BTM. This Sim-2 ... 10/06/05 - 20050222385 - Hybrid and tandem expression of neisserial proteins Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH2-A-[-X-L-]n-B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is ... 09/15/05 - 20050203282 - G-coupled receptor showing selective affinity for atp The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention ... 09/15/05 - 20050203281 - Production of recombinant fragments of muscle acetylcholine receptor and their use for ex vivo immunoadsorption of anti-ch receptor antibodies from myasthenic patients A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous systems and obtained in sufficiently folded state appropriate for binding major fractions of anti-AChR antibodies in myasthenia gravis (MG) patients and of immunoadsorbing these ... 09/15/05 - 20050203280 - Alloiococcus otitidis open reading frames (orfs) encoding polypeptide antigens, immunogenic compositions and uses thereof The present invention relates to the complete genomic sequence of Gram-positive bacterium, Alloiococcus otitidis. The present invention also relates to polynucleotide sequences encoding polypeptides of Alloiococcus otitidis. In particular, the invention relates to antigenic polypeptides encoded by the Alloiococcus otitidis open reading frames (ORFs), and to their use in immunogenic ... 09/08/05 - 20050197492 - Crystal structure of vegfrkd: ligand complexes and methods of use thereof Polypeptides containing the kinase domain of a VEGFR are described. Also described are crystal structures of these polypeptides, including the crystal structures of VEGFR2KD:ligand complexes. The atomic coordinates derived from the crystal structures provide a three-dimensional description of the ligand-binding pocket of the kinase domain useful in drug discovery and ... 09/08/05 - 20050197491 - Human ependymin The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin protein. Ependymin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention ... 09/01/05 - 20050192427 - Novel death domain proteins In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also ... 08/18/05 - 20050182245 - Novel receptors The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors. ... 08/18/05 - 20050182244 - Modified polypeptides stabilized in a desired conformation and methods for producing same The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock ... 08/18/05 - 20050182243 - Membrane scaffold proteins The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence ... 08/18/05 - 20050182242 - Global analysis of protein activities using proteome chips The present invention relates to proteome chips comprising arrays having a large proportion of all proteins expressed in a single species. The invention also relates to methods for making proteome chips. The invention also relates to methods for using proteome chips to systematically assay all protein interactions in a species ... 08/11/05 - 20050176932 - Method for refolding of proteins A method of refolding proteins from a suspension comprising the proteins in a predominately misfolded form. The method involves adding of a denaturant to the suspension comprising the misfolded proteins to obtain the proteins in a substantially unfolded form. The suspension comprising the unfolded proteins is diluted so as to ... 08/11/05 - 20050176931 - Eotaxin : eosinophil chemotactic cytokine A chemoattractant protein called “eotaxin” is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that inhibit or otherwise hinder the production, release or activity of eotaxin may be used therapeutically in the treatment of asthma and other inflammatory ... 08/11/05 - 20050176930 - Marker molecules associated with lung tumors The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts ... 08/11/05 - 20050176929 - Hiv-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates |