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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Sulfur Containing Hetero Ring > The Hetero Ring Is Five-membered > Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Polycyclo Ring System Having The Hetero Ring As One Of The CyclosPolycyclo Ring System Having The Hetero Ring As One Of The Cyclos patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/25/07 - 20070021493 - Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity. ... 01/25/07 - 20070021492 - Sulfamatet benzothiophene derivatives as steroid sulfatase inhibitors The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them. ... 01/04/07 - 20070004794 - Novel salicylic anilides Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity. ... 12/21/06 - 20060287387 - Fused tricyclic heterocycles useful for treating hyper-proliferative disorders and its use for the treatment of hyper-proliferative disorders. ... 12/21/06 - 20060287386 - Benzo[b]furane and benzo[b]thiophene derivatives The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use. ... 12/21/06 - 20060287385 - Small organic molecule regulators of cell proliferation The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit ... 11/16/06 - 20060258735 - 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic ... 08/24/06 - 20060189678 - 4,5-dihydronaphtho[1,2-b]thiophene derivative (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 ... 06/08/06 - 20060122257 - Phenyl substituted carboxylic acids which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative ... 05/25/06 - 20060111430 - 2,3,4-substituted cyclopentanones as therapeutic agents or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments related thereto are also disclosed. ... 05/18/06 - 20060106089 - Bissulfonamide compounds as agonists of galr1, compositions, and methods of use Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions. ... 05/18/06 - 20060106088 - 2,3,4-substituted cyclopentanones as therapeutic agents E is an aromatic heterobicyclic ring system which may have substituents comprising up to 6 non-hydrogen atoms each. Methods, compositions, and medicaments related thereto are also disclosed. ... 03/30/06 - 20060069149 - Thiadibenzoazulene derivatives for the treatment of inflammatory diseases The present invention relates to (a) novel 1-thiadibenzoazulene derivatives of the formula (I), (b) to their pharmacologically acceptable esters, salts and solvates, (c) to processes and intermediates for the preparation thereof, (d) to a process for preparing pharmaceutical formulations for the treatment of inflammatory diseases and conditions and (e) to ... 03/16/06 - 20060058371 - Nf-kb inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in which diseases excessive activation of NF-κB is implicated. ... 02/09/06 - 20060030616 - Anhydride modified cantharidin analogues useful in the treatment of cancer Anhydride modified cantharidin analogues useful in the treatment of certain forms of cancer also methods for the screening for anti-cancer activity of these analogues and/or their ability to sensitise cancer cells to cancer treatment. The modified cantharidin analogues have structure (I) or (II), wherein R1, R2, R3 and R4 are ... 02/02/06 - 20060025473 - Pharmaceutical formulations containing substituted 2 heteroarylaminoacetic acid compounds Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds corresponding to formula I and their use in the production of drugs and in related methods of treatment or inhibition of certain conditions or diseases. ... 12/01/05 - 20050267200 - Heteroaromate osc inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes. ... 11/10/05 - 20050250843 - Medicinal compositions improving brain function and method for improving brain function wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. ... 07/28/05 - 20050165086 - Nf-kb inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in which diseases excessive activation of NF-κB is implicated. ... 07/21/05 - 20050159476 - Pharmaceutical composition for preventing or treating respiratory disease An object of the present invention is to provide a pharmaceutical composition and a method for preventing or treating a respiratory disease. The pharmaceutical composition comprises a compound represented by formula (1): or a pharmaceutically acceptable salt thereof as an active ingredient. ... 06/23/05 - 20050137249 - 1-or 3-thia-benznaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well ... ### FreshPatents.com Support |