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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Five-membered Hetero Ring Containing At Least One Nitrogen Ring Atom (e.g., 1,2,3-triazoles, Etc.) > The Five-membered Hetero Ring Consists Of One Nitrogen And Four Carbons > Polycyclo Ring System Having The Five-membered Hetero Ring As One Of The Cyclos > Tricyclo Ring System Having The Five-membered Hetero Ring As One Of The Cyclos Tricyclo Ring System Having The Five-membered Hetero Ring As One Of The CyclosTricyclo Ring System Having The Five-membered Hetero Ring As One Of The Cyclos patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.02/01/07 - 20070027202 - Process for the preparation of carvedilol and its salts Disclosed herein is a process for preparation of carvedilol substantially free from its bis-impurity comprises the reaction of 4-(2,3-epoxypropoxy)carbazole and 2-(2-methoxyphenoxy)ethylamine in a polar aprotic solvent media; followed by isolation of carvediol from the reaction mass as an acid addition salt and subsequent conversion into pure carvedilol. ... 12/14/06 - 20060281804 - Novel cycloalkyl'b! condensed indoles The present invention relates to compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds. ... 11/30/06 - 20060270729 - Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production ... 11/30/06 - 20060270728 - Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) wherein: X is an alkali metal or a basic amine moiety; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl, the rings of these groups being optionally substituted; R2 is H, halogen, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —NH2, or —NO2; R3 is phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, with ... 11/02/06 - 20060247295 - Cytotoxic compounds and conjugates with cleavable substrates The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them. ... 09/21/06 - 20060211758 - M3 muscarinic acetylcholine receptor antagonists Novel thiazole aniline compounds, pharmaceutical compositions, methods of making them and uses thereof in treating M3 muscarinic acetylcholine receptor mediated diseases are disclosed. ... 08/10/06 - 20060178418 - Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders:process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... 07/27/06 - 20060167077 - Process for preparation of carvedilol The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated ... 07/20/06 - 20060160876 - Indole derivatives Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ... 07/20/06 - 20060160875 - Matrix metalloproteinase inhibitors R10 and R11 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described. ... 07/13/06 - 20060154979 - Use of alpha-phenylthiocarboxylic and alpha-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the preparation of a medicine for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, its complications, the various forms of insulin resistance, ... 07/06/06 - 20060148878 - Pseudopolymorphic forms of carvedilol The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them. ... 05/25/06 - 20060111424 - Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... 05/04/06 - 20060094771 - Carvedilol pharmasolve solvate This invention relates to carvedilol pharmasolve solvate, compositions containing this compound and methods of using carvedilol pharmasolve solvate to treat hypertension, congestive heart failure and angina. ... 04/13/06 - 20060079567 - Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for ... 04/06/06 - 20060074124 - Methods of treating a disorder and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders. ... 03/30/06 - 20060069148 - Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases. ... 03/23/06 - 20060063821 - Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus wherein substitutions at R1-R13, m and Y are set forth in the specification. ... 02/23/06 - 20060041004 - Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4h-carbazol-4-one and ondansetron therefrom The present invention provides a rapid, high-yielding process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one without using a secondary amine as a catalyst, and without using glacial acetic acid as a solvent. The present invention further provides a rapid, high-yielding process for preparing ondansetron from 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one without using alumina as a catalyst. ... 02/23/06 - 20060041003 - Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone ... 02/09/06 - 20060030614 - Carvedilol This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof. ... 01/19/06 - 20060014818 - Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of g-protein coupled receptors (gpcrs) The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends on the pathobiochemical effect of GPCRs. The compounds of the invention act in ... 01/05/06 - 20060004081 - Cytotoxic compounds and conjugates The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them. ... 12/15/05 - 20050277689 - Carvedilol salts, corresponding compositions, methods of delivery and/or treatment The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or ... 12/08/05 - 20050272799 - Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... 12/08/05 - 20050272798 - Disulfide prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides ... 11/24/05 - 20050261356 - Methods and compositions for the treatment of chronic lymphocytic leukemia The level of the leukemic lymphocytes in patients suffering from chronic lymphocytic leukemia (CLL) is reduced by the administration of certain indole or carbazole compounds, such as the nonsteroidal anti-inflammatory drug etodolac or related indole or carbazol compounds. ... 11/24/05 - 20050261355 - Carvedilol hydobromide The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of ... 11/17/05 - 20050256181 - Treating a viral disorder Heterocyclic compounds of formula (I) and methods of treating or preventing an HIV-mediated disorder by administering a compound of formula (I) are described herein. ... 11/10/05 - 20050250836 - Inhibitors of checkpoint kinases (wee1 and chk1) This invention relates to substituted indacene molecules that specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 and are useful in the treatment of proliferative disorders. ... 11/10/05 - 20050250835 - Novel tumor-selective chemotherapeutic agents The present invention relates to novel CC-1065 derivatives that bind to albumin in vitro and in vivo forming albumin-drug conjugates, and their methods of preparation and use as antitumor agents. ... 11/03/05 - 20050245590 - Crystalline forms of imidoalkanpercarboxylic acids Imidoalkancarboxylic acids of formula (I) are described, wherein A, X and M are as defined in the application, said acids being in a crystalline form which in contact with water gives rise to crystals having sizes lower than 30 micron. ... 10/27/05 - 20050239864 - Novel tumor-selective chemotherapeutic agents The present invention relates to novel CC-1065 derivatives that bind to albumin in vitro and in vivo forming albumin-drug conjugates, and their methods of preparation and use as antitumor agents. ... 09/22/05 - 20050209300 - Methods of treating a disorder and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders. ... 09/08/05 - 20050197380 - Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, ... 09/08/05 - 20050197379 - Macrolides and methods for producing same This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them. ... 09/01/05 - 20050192334 - Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, ... 08/25/05 - 20050187282 - Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, ... 07/14/05 - 20050154044 - Substituted tetrahydrocarbazole and cyclopentanoindole derivatives The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion. ... 07/07/05 - 20050148651 - Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl-(amine- derived)] compounds and analogues thereof, and to products obtained therefrom The invention provides processes of preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl(amine-derived)] compounds of formula (I) and its analogues, or a physiologically functional derivative thereof, (I), wherein A and B together may represent a fused optionally substituted benezene, naphthalene, pyridine, furan or a pyrrole ring, where the optional substituents are represented by ... 06/09/05 - 20050124680 - Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases. ... ### FreshPatents.com Support |