REGISTER now for FREE 
|
FREE patent keyword monitoring and additional FREE benefits. REGISTER now for FREE
|
|
|
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Five-membered Hetero Ring Containing At Least One Nitrogen Ring Atom (e.g., 1,2,3-triazoles, Etc.) > Tetrazoles (including Hydrogenated) > Polycyclo Ring System Having The Diazole Ring As One Of The Cyclos > Benzo Fused At 4,5-positions Of The Diazole Ring Benzo Fused At 4,5-positions Of The Diazole RingBenzo Fused At 4,5-positions Of The Diazole Ring patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.02/01/07 - 20070027200 - Bis-benzimidazoles and related compounds as potassium channel modulators The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods. ... 01/25/07 - 20070021483 - Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for ... 01/25/07 - 20070021482 - 1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the gabaa receptor complex The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex. ... 12/28/06 - 20060293377 - Amorphous and polymorphic forms of telmisartan sodium Provided is the amorphous form of telmisartan sodium and the preparation thereof. Also provided are the telmisartan sodium polymorph crystal Forms 0 to XIII and XV to XX and preparations thereof. Also provided are pharmaceutical composition of amorphous and polymorphic forms of telmisartan sodium or mixtures thereof, and methods of ... 12/28/06 - 20060293376 - Benzopyran derivatives substituted with a benzimidazole derviative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect ... 12/28/06 - 20060293375 - Crystal of benzimidazole derivative and process for producing the same Various crystal forms of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid from a solvent, and a process for production thereof are provided. ... 12/14/06 - 20060281802 - Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of Formula 1 in admixture with a pharmaceutically acceptable carrier or excipient. The compositions may include additional therapeutic agents for combination therapy. The present invention provides a new class of pharmaceutically ... 12/07/06 - 20060276526 - Crystalline form of telmisartan sodium The invention relates to a crystalline sodium salt of 4′-[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid (INN: telmisartan), processes for preparing it and the use thereof for preparing a pharmaceutical composition. ... 12/07/06 - 20060276525 - Processes of preparing highly pure telmisartan form a, suitable for pharmaceutical compositions Processes are disclosed for preparing Telmisartan form A, which is free-flowing and which does not contain electrostatic charge and is thus industrially process-able. The free-flowing Telmisartan form A is prepared by crystallization from a polar organic solvent e.g., DMSO, DMF, DMA, NMP, or water and is suitable for use in ... 11/23/06 - 20060264492 - Benzimidazole vascular damaging agents wherein A represents a multi-substituted alkyl group or aromatic ring. ... 11/23/06 - 20060264491 - Telmisartan production process The present invention provides an intermediate and a process for preparing Telmisartan, which overcomes the drawbacks of conventional methods and produces Telmisartan in high purity and yield. ... 11/23/06 - 20060264490 - Compounds, compositions containing them, preparation thereof and uses thereof i wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. ... 11/02/06 - 20060247290 - Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3) alkyl, (C1-C3) alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a ... 11/02/06 - 20060247289 - Certain chemical entities, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. ... 10/12/06 - 20060229351 - 2-substituted-1 h-benzimidazile-4-carboxamides are parp inhibitors inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I). ... 09/14/06 - 20060205803 - 1,2 diarylbenzimidazoles and their pharmaceutical use and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described. ... 09/14/06 - 20060205802 - Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. ... 08/31/06 - 20060194859 - Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... 08/24/06 - 20060189672 - Viral polymerase inhibitors wherein wherein A, B, R2, R3, M1, M2, M3, M4, Y1 and Z are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase. ... 08/17/06 - 20060183784 - Human growth hormone antagonists wherein X, R1, R2, R3, R4 and R5 are as defined herein. ... 07/20/06 - 20060160872 - Vanilloid receptor ligands and their use in treatments Substituted benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory ... 07/13/06 - 20060154977 - Therapeutic molecules and methods-1 Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of ... 07/06/06 - 20060148873 - Low-temperature-stable preservatives A liquid, cold-temperature-stabilized preservative is based on carbendazim or a salt thereof, which includes, as low-temperature stabilizer, at least one aromatic alcohol and/or at least one aromatic glycol ether and/or a pyrrolidone. ... 06/29/06 - 20060142365 - Benzimidazole compounds and antiviral uses thereof The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of benzimidazole compounds as inhibitors of ... 06/29/06 - 20060142364 - Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R1, R2, RF1, RF2 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. ... 06/15/06 - 20060128777 - Cancer treatments Methods and compositions for treating cancers characterized by death-resistant cancer cells are described. In general, such methods involve administration of a therapeutically effective amount of a compound that induces mitotic catastrophe in the some, and preferably most or all, of the cancerous cells. Methods for assessing the efficacy of such ... 06/08/06 - 20060122248 - Methods of making 6-[(4,5-dihydro-1h-imidazol-2-yl)amino-]-7-methyl-1h-benzimidazole-4-carbonitrile and its preferred salt form 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension. ... 06/01/06 - 20060116412 - Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms) The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... 05/25/06 - 20060111417 - Amorphous telmisartan Amorphous telmisartan and combinations of amorphous telmisartan with one or more pharmaceutical carriers. ... 05/25/06 - 20060111416 - Octahydropyrrolo[3,4-c]pyrrole derivatives and to processes for the preparation thereof, compositions containing the same and the uses thereof. ... 05/25/06 - 20060111415 - 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, R1 and R2 are defined herein. ... 05/25/06 - 20060111414 - 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, R1, R2, Y and Z are defined herein. ... 05/25/06 - 20060111413 - 2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, R1, R2, X, Y and Z are defined herein. ... 05/18/06 - 20060106081 - Benzimidazole acetic acids exhibiting crth2 receptor antagonism and uses thereof The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to ... 05/04/06 - 20060094770 - 1,2 diarylbenzimidazoles and their pharmaceutical use and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described. ... 04/20/06 - 20060084691 - Combined treatment with bortezomib and an epidermal growth factor receptor kinase inhibitor The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and bortezomib combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. ... 04/13/06 - 20060079564 - Indazole benzimidazole compounds A method of inhibiting c-ABL in a patient includes administering an effective amount of a compound of structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer to the patient. ... 04/06/06 - 20060074119 - Thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... 02/16/06 - 20060035951 - N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer. ... 02/02/06 - 20060025464 - Benzimidazole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced ... 12/29/05 - 20050288349 - Cancer treatments and pharmaceutical compositions therefor wherein R is selected from the group consisting of H, carboxyl (—CO2H), hydroxyl, amino or esters (—CO2R′) wherein R′ is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl wherein the alkyl groups have from 1-8 carbons or CH3CH2(OCH2CH2)n— or CH3CH2CH2(OCH2CH2CH2)n— or (CH3)2CH—(OCH(CH3)CH2)n— wherein n is from 1-3, ... 12/29/05 - 20050288348 - Compounds and methods for use thereof in the treatment of cancer Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator. ... 12/15/05 - 20050277686 - Benzimidazole compounds for regulating ige This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. ... 12/08/05 - 20050272792 - Benzimidazoles, process for their preparation and use thereof as medicament wherein R1 to R6 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. ... 12/08/05 - 20050272791 - Benzimidazoles and benzothiazoles as inhibitors of map kinase The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis. ... 11/17/05 - 20050256179 - Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases Preferred aspects of the present invention relate to the inhibition of intracellular protein trafficking pathways through selective pharmacologic down-regulation of specific resident ER and golgi proteins, and more particularly, to methods of treating a variety of disease conditions, which depend on these intracellular protein trafficking pathways. ... 11/10/05 - 20050250833 - Derivatives of n-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed. ... 11/10/05 - 20050250832 - Novel benzimidazol-2-one derivatives and their use The present invention provides novel benzimidazol-2-one derivatives useful as therapeutic agents. ... 11/10/05 - 20050250831 - Peroxisome proliferator activated receptor modulators The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula 1: and pharmaceutically acceptable salts thereof, wherein: (a) W is selected from the group consisting of O, C, N and S: (b) Z is an aliphatic linker wherein one carbon atom ... 10/27/05 - 20050239855 - Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of ... 10/06/05 - 20050222236 - Viral polymerase inhibitors wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase. ... 09/15/05 - 20050203158 - Substituted benzimidazole compounds wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds. ... 09/08/05 - 20050197376 - Concomitant drugs This invention provides a pharmaceutical agent containing, in combination, a sulfonamide compound and other therapeutic agent, preferably, at least one compound represented by the formula (I): R1—SO2—NH—CO-A1-CH2—R2 [each symbol is as defined in the specification] or a pharmaceutically acceptable salt thereof, and at least one pharmaceutical agent selected from the ... 09/08/05 - 20050197375 - Use of benzimidazole analogs in the treatment of cell proliferation The preferred embodiments are directed to small molecule inhibitors that are cellular proliferation inhibitors and thus are useful as anticancer agents. The small molecules have the general formulas that include a phenylbenzimidazole core ring. ... 09/01/05 - 20050192329 - Treating agent for irritable bowel syndrome A therapeutic method and pharmaceutical compositions for treatment of irritable bowel syndrome including non-constipated irritable bowel syndrome such as diarrhea-predominant irritable bowel syndrome and alternating constipation/diarrhea irritable bowel syndrome in male and female patients, which may comprise administering a patient with from 0.001 to 0.05 mg of ramosetron hydrochloride as ... 09/01/05 - 20050192328 - Compounds and methods for use thereof in the treatment of viral infections Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator. ... 08/11/05 - 20050176797 - 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed. ... 08/04/05 - 20050171175 - Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9—; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is —C(═O)—, —O—C(═O)—, ... 07/14/05 - 20050154040 - Nitrogen-containing heteroaryl derivatives Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections. ... 07/14/05 - 20050154039 - 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine The invention concerns novel 5-sulphanyl-4<I>H</I>-1,2,4-triazole derivatives of formula (1), wherein: R1, R2 and R3 represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein ... 07/07/05 - 20050148646 - Dicationic triaryl analogs as anti-protozoan agents Novel dicationic, heterocyclic triaryl compounds are useful in the treatment of microbial infections, such as Trypanosoma brucei rhodesiense infection and Plasmodium falciparum infection. These compounds are accordingly useful in treating second-stage human African trypanosomiasis. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections. ... 06/30/05 - 20050143439 - 1-aryl-2-n-, s- or o-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of ... 06/30/05 - 20050143438 - N3 alkylated benzimidazole derivatives as mek inhibitors and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such ... 06/23/05 - 20050137242 - Betamimetics having a long-lasting activity, processes for preparing them, and their use as medicaments R6 is a methoxyphenyl group, if X is nitrogen, or is an anellated phenyl ring also linked to X, if X is carbon, or the individual optical isomers, mixtures of the individual enantiomers, racemates, or acid addition salt thereof. ... 06/23/05 - 20050137241 - Imidazole derivatives, processes for preparing them and their uses The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... 06/09/05 - 20050124678 - Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. ... ### FreshPatents.com Support |