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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Five-membered Hetero Ring Containing At Least One Nitrogen Ring Atom (e.g., 1,2,3-triazoles, Etc.) > 1,3,4-thiadiazoles (including Hydrogenated) > 1,3-thiazoles (including Hydrogenated) 1,3-thiazoles (including Hydrogenated)1,3-thiazoles (including Hydrogenated) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.02/01/07 - 20070027196 - Activator of peroxisome proliferator-activated receptor delta (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents ... 01/18/07 - 20070015802 - Inhibitors of cyclin dependent kinases and their use wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of ... 01/04/07 - 20070004786 - Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles ... 12/28/06 - 20060293371 - Prodrug and process for producing the same wherein each symbol is as defined in the specification. According to the present invention, the development of a prodrug based on the modification of a nitrogen-containing heterocycle and the like has become possible. ... 12/21/06 - 20060287371 - Epothilone derivatives in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof. ... 12/21/06 - 20060287370 - Isoindolinone kinase inhibitors are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... 12/21/06 - 20060287369 - Diarylmethyl and related compounds wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, ... 12/14/06 - 20060281796 - Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also ... 12/07/06 - 20060276519 - Thiazole derivatives for treating ppar related disorders The present invention provides combinations of compounds of formula (I) and other therapeutic agents for the treatment of PPAR related diseases. ... 11/23/06 - 20060264482 - Epothilones c, d, e and f, preparation and compositions The present invention relates to epothilones C, D, E and F, their preparation and their use for the production of therapeutic compositions and compositions for plant production. ... 11/16/06 - 20060258721 - Substituted indole compounds having nos inhibitory activity The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such ... 11/16/06 - 20060258720 - 1-acyl-pyrrolidine derivatives for the treatment of viral infections A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from ... 11/09/06 - 20060252808 - Methods for treating nephrolithiasis The present invention relates to methods of treating subjects suffering from nephrolithiasis by administering to a subject in need of treatment thereof a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof. ... 10/26/06 - 20060241156 - Preparation of epothilone derivatives wherein R3 is methyl or trifluoromethyl. The desoxepothilones of formula IV inhibit the growth of tumor cells and are therefore promising candidates for novel anticancer agents. ... 10/19/06 - 20060235059 - Cancer treatment with epothilones The present invention relates to an in vivo regimen for the treatment of a proliferative disease, where an epothilone, is administered in a loading dose followed by at least 1, maintenance doses. ... 10/12/06 - 20060229345 - Compositions comprising epothilones and their use for the treatment of carcinoid syndrome wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, R′ is methyl, methoxy, ethoxy, amino, methylamino, dimethylamino, aminomethyl or methylthio, and Z is O or a bond, or a pharmaceutically acceptable salt thereof, alone or in combination with at least ... 10/05/06 - 20060223867 - Cancer treatment with epothilones The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone. ... 10/05/06 - 20060223866 - Methods and compositions for modulating sphingosine-1-phosphate (s1p) receptor activity The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds. ... 09/21/06 - 20060211746 - Desferrithiocin derivatives and methods of use thereof are highly efficient in clearing excess iron from an organism. The invention also discloses methods of treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions. ... 09/14/06 - 20060205795 - Cancer treatment with epothilones The use of an epothilone for the treatment of a proliferative disease comprising the step of daily administration of a therapeutically effective amount of an epothilone by continuous intravenous (i.v.) administration. ... 08/31/06 - 20060194852 - Glutaminyl based dpiv inhibitors wherein X═CH2 or S or pharmaceutical acceptable salts thereof useful for treating conditions mediated by DPIV or DPIV-like enzymes, such as arthritis, obesity, immune and autoimmune disorders, allograft transplantation, cancer, neuronal disorders and dermal diseases. ... 08/31/06 - 20060194851 - Benzofuran compound and medicinal composition containing the same wherein each symbol is as defined in the description, a pharmaceutically acceptable salt thereof and the like. The compound of the present invention has superior leukotriene inhibitory action, BLT2 competitive inhibitory action, BLT2 blocking action, action for the prophylaxis or treatment of allergy, action for the prophylaxis or treatment of ... 08/17/06 - 20060183781 - Novel thiazolylmethyl pyrazoles, method for the production thereof, and use thereof in dyes for keratin fibers wherein R denotes a straight-chain or branched C1-C6-alkyl group, an unsubstituted phenyl group or a singly or multiply substituted phenyl group wherein the substituents are selected independently of each other from among a halogen atom, a C1-C6 carboxylate ester group, a straight-chain or branched C1-C6-alkoxy group, a straight-chain or branched ... // - 4,5-Diaminopyrazoles of general formula (I) - ... 08/03/06 - 20060173056 - Proline derivatives and use thereof as drugs wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability. ... 07/27/06 - 20060167066 - Pyrrolidine inhibitors of iap wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6′ and R6′ are as described herein. ... 07/27/06 - 20060167065 - Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions. ... 07/06/06 - 20060148865 - Preparation of chemical compounds The present invention is directed to processes for the preparation of N-(3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-yl-oxycarbonyl-, (4S,5R)-4-[4-(2-methylthiazolo-4-methyloxy)-benzyl]-5-i-butyl-[(3,4-methylenedioxyphenyl)sulfonyl]-aminomethyl-2,2-dimethyl-oxazolidine. ... 06/29/06 - 20060142354 - Use of epothilone derivatives for the treatment of hyperparathyroidism or a pharmaceutically acceptable salt thereof. ... 06/22/06 - 20060135572 - Casr antagonist wherein each symbol is as defined in the description. ... 06/15/06 - 20060128770 - Thiazole derivatives A compound of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes ... 06/15/06 - 20060128769 - Thiazoyl biphenyl amides in which R1, R2, R3, R4, R5 and R6 are as defined in the disclosure, to a process for preparing these compounds and to their use for controlling unwanted microorganisms. ... 06/15/06 - 20060128768 - Furanthiazole derivatives as heparanase inhibitors The invention provides a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof. (I) wherein the groups Q, R2, R3, R4 and R5 represent various substituent groups, and their use as inhibitors of heparanase. ... 06/08/06 - 20060122241 - Novel macrocycles for the treatment of cancer diseases The present invention relates to novel macrocycles of the general formula (I) and to the use thereof in the treatment of cancer diseases. ... 06/01/06 - 20060116406 - 7-(1,3-thiazol-2-yl)thio!-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. ... 05/18/06 - 20060106073 - Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same wherein R1 is methyl, and R2 is an unsubstituted or substituted aryl; an unsubstituted or substituted heteroaryl; or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus; and salts thereof, and intermediates for the synthesis of a compound of formula 9 ... 05/04/06 - 20060094766 - Epothilone derivatives for the treatment of multiple myeloma to a combination comprising an epothilone, for simultaneous, separate or sequential use; and to a pharmaceutical composition and a commercial package comprising said combination. ... 04/27/06 - 20060089395 - Nf-kb activation inhibitors wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is {circle around (1)} a fused polycyclic heteroaryl group wherein the ring ... 03/30/06 - 20060069136 - Use of epothilones in the treatment of bone metastasis The present invention relates to the use of Epothilones in the treatment of bone metastases and bone tumors or cancers, more particularly in treating, preventing or alleviating bone metastasis in a cancer patient. ... 03/30/06 - 20060069135 - Benzimidazole derivatives and their use for modulating the gaba-a receptor complex The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases. ... 03/30/06 - 20060069134 - Process for producing optically active alpha-substituted cysteine or salt thereof, intermediate therefor, and process for producing the same The present invention provides a simple, practical, and industrially advantageous process for producing an optically active α-substituted cysteine or a salt thereof from inexpensive and readily available materials. The present invention provides a process for producing an optically active α-substituted cysteine or a salt thereof by converting a cysteine derivative ... 03/23/06 - 20060063815 - Polymorphs of an epothilone analog Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them. ... 03/23/06 - 20060063814 - Substituted hydantoins which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases. ... 02/16/06 - 20060035945 - Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or ... 02/16/06 - 20060035944 - Remedies for neurodegenerative diseases wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is {circle around (1)} a fused polycyclic heteroaryl group wherein the ring ... 02/09/06 - 20060030606 - Cyclohexyl prostaglandin analogs as ep4-receptor agonists wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1, R2 and R3 are as defined in the specification. ... 02/09/06 - 20060030605 - Pharmaceutical compounds Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bivalent ... 02/02/06 - 20060025458 - Alkylammonium compounds as antifungal and antitrypanosomal agents The use of alkyl quaternary ammonium compounds including certain choline analogs for treating or preventing fungal and trypanosomal (e.g., Leishmaniasis) infections is described. These compounds, characterized as mono- and bis-alkyl ammonium compounds, were demonstrated to be highly effective in inhibiting growth of Candida albicans, Saccharomyces cerevisiae and Leishmania major. Quaternary ... 01/26/06 - 20060020000 - Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective ... 01/26/06 - 20060019999 - Novel compounds There are provided novel compounds of formula (I) wherein R1, R2, R3, R10, M, Q, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors ... 01/05/06 - 20060004065 - Novel macrocycles for the treatment of cancer The present invention relates to new Macro-cycles of Formula (I), and their use for the treatment of cancer. ... 12/29/05 - 20050288340 - Substituted heteroaryl- and phenylsulfamoyl compounds The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including ... 12/22/05 - 20050282873 - Epothilone derivative for the treatment of hepatoma and other cancer diseases The present invention relates to a method of treating a warm-blooded animal, especially a human, having a cancer disease selected from hepatoma; primary fallopian tube cancer; primary peritoneal cancer; breast cancer progressing after treatment with hormonal agents or radiotherapy; renal cell carcinoma progressing after treatment with a cytokine, radiotherapy and/or ... 12/15/05 - 20050277683 - Novel pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections. ... 12/15/05 - 20050277682 - Therapeutic formulations of desoxyepothilones Formulations of desoxyepothilones are stable before and after dilution into aqueous media. ... 12/08/05 - 20050272785 - Biphenyl carboxamides R1, R2, m, n, R3, Y and A are as defined in the description, a plurality of processes for preparing these substances and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation. ... 12/01/05 - 20050267174 - Condensation reagents and a process for their preparation R1, R2, R3, R4, n and X have the meaning indicated in the disclosure, a process for their preparation, their use as condensation reagents, particularly as peptide coupling reagents, and intermediates for the preparation of these compounds. ... 12/01/05 - 20050267173 - Serine protease inhibitors where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... 11/10/05 - 20050250823 - Gyrase inhibitors Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B. ... 11/10/05 - 20050250822 - Substituted benzanilide compound and noxious organism controlling agent wherein G represents a ring such as G-7, G-13 and G-71, etc., W1 and W2 each independently represent oxygen atom or sulfur atom, X represents halogen atom, etc., Y represents C1 to C6 alkyl, etc., R1, R2 and R3 each independently represent hydrogen atom, a C1 to C12 alkyl or ... 10/20/05 - 20050234114 - Therapeutic calcium phosphate particles and methods of making and using same The present invention provides calcium phosphate nano-particles encapsulated with biologically active macromolecules. The particles may be used as carriers of biologically active macromolecule for delivery of the macromolecules. The invention also provides methods of making and using the particles. ... 10/20/05 - 20050234113 - Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin Free radicals and reactive oxygen species have the potential to damage a wide variety of organic molecules, typically by oxidizing certain moieties. These damaging species can, for example, be produced by an organism as a by-product of cellular respiration or by the reaction of iron(II) and peroxide. The present invention ... 10/06/05 - 20050222223 - Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders wherein R1 to R6, X, Z and A are as defined. These compounds have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the present Formula. ... 10/06/05 - 20050222222 - Pyrrolidine compounds wherein R1 R2, R3, R4, R5, R6, W, X, Y, Z, m, n, and p are as defined herein. This invention also covers methods for inhibiting dipeptidyl peptidase IV or VIII, or treating Type II diabetes with such a compound. ... 10/06/05 - 20050222221 - Method for the improvement of islet signaling in diabetes mellitus and for its prevention The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic β-cells and to cause differentiation of pancreatic epithelial cells into insulin producing β-cells. Oral administration a DP IV inhibitor causes the active form of ... 09/29/05 - 20050215604 - Combination therapies with epothilones and carboplatin A combination therapy of an epothilone and carboplatin is effective for treating tumors. ... 09/29/05 - 20050215603 - Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. ... 09/15/05 - 20050203152 - Polymorph of a pharmaceutical A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed. ... 09/15/05 - 20050203151 - Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions Described herein are novel mono- and bicyclic compounds compounds, including compounds capable of modulating the activity of human peroxisome proliferator activated receptor of the subtype delta (hPPAR-delta), and methods for utilizing such modulation to treat a disease or condition mediated or impacted by hPPAR-delta activity such as Type 2 diabetes, ... 09/01/05 - 20050192324 - Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors their analogs, isomers, pharmaceutical compositions, therapeutic uses and methods of making the same. ... 08/25/05 - 20050187271 - Use of 2-methyl-thiazolidine-2,4-dicarboxylic acid and/or its physiologically tolerable salts as a cancer-fighting agent Use of 2-methyl-thiazolidine-2,4-dicarboxylic acid (2-MTDC) and/or its physiologically tolerable salts for the treatment and/or prevention of cancer. ... 08/25/05 - 20050187270 - 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use A compound of formula C, BC and ABC. ... 08/11/05 - 20050176785 - Process for preparing thiazole derivative and the intermediate compounds for preparing the same The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPARδ), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of formula (XI). ... 08/04/05 - 20050171167 - Process and formulation containing epothilones and analogs thereof A process for formulating certain epothilones and analogs thereof for parenteral administration is provided wherein the pH of the formulation for administration can be controlled to enhance the stability and thus, potency of the epothilone, or analog thereof. ... 08/04/05 - 20050171166 - Substituted 5-membered n-heterocyclic compounds and their uses for treating or preventing neurodegenerative diseases This invention relates to substituted 5-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, R3, R4, V, W, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 ... 07/28/05 - 20050165071 - Cancer treatment with epothilones The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone. ... 07/28/05 - 20050165070 - Compositions with a biostimulating activity A description follows of compositions with a biostimulating activity comprising at least two components selected from a thiazolidine-4-carboxylic acid, an N-acyl derivative of thiazolidine-4-carboxylic acid and/or an amino acid component consisting of one or more essential amino acid. ... 07/21/05 - 20050159461 - Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. ... 07/21/05 - 20050159460 - Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease The present invention relates to methods of treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of known compounds of formula (I) wherein R1, R2, R3, U′, U″, V, Y, W, Q, R′ are as defined herein. ... 07/07/05 - 20050148641 - 2-methylthiazolidine-2,4-dicarboxylic acid and salts thereof for the treatment of neurodegenerative diseases The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases, methods for the prophylaxis and/or treatment of neurodegenerative diseases, and pharmaceutical compositions containing said compounds together with physiologically compatible carriers, auxiliary agents, ... 06/30/05 - 20050143429 - Synthesis of epothilones, intermediates thereto, analogues and uses thereof as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I). ... 06/30/05 - 20050143428 - Disubstituted thiazolyl carboxanilides and their use as microbicides R1 and R2 are as defined in the disclosure, to a plurality of processes for preparing these substances and their use for controlling unwanted microorganisms, and further relates to novel intermediates of their preparation. ... 06/16/05 - 20050131035 - Medicaments Methods or prevention or treatment of inflammatory diseases or conditions, the use of PPAR delta activators in such methods and methods for the identification of compounds useful in such treatment. ... 06/09/05 - 20050124673 - Methods of preparing compounds useful as protease inhibitors useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I). ... 06/09/05 - 20050124672 - N-phenylarylsulfonamide compound drug containing the compound as active ingredient intermediate for the compound and processes for producing the same (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its ... 06/02/05 - 20050119318 - Inhibitors of hcv replication are disclosed. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5B protein. ... 06/02/05 - 20050119317 - Isoxazoline derivatives useful as antimicrobials processes for their manufacture and pharmaceutical compositions containing them are described. ... ### FreshPatents.com Support |