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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms > Nitrogen Attached Indirectly To The Six-membered Hetero Ring By Nonionic Bonding Nitrogen Attached Indirectly To The Six-membered Hetero Ring By Nonionic BondingNitrogen Attached Indirectly To The Six-membered Hetero Ring By Nonionic Bonding patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/25/07 - 20070021474 - Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals where the radicals are defined as specified, and also their pharmaceutically acceptable salts and processes for their preparation. The compounds are suitable, for example, for treating type 2 diabetes. ... 01/11/07 - 20070010564 - Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. ... 12/28/06 - 20060293369 - Fungicidal composition comprising a pyridylmethylbenzamide derivative and chlorothalonil A fungicidal composition comprising at least a pyridylmethylbenzamide derivative of general formula (I) and a chloronitrile derivative which is chlorothalonil; in a compound (I)/chlorothalonil weight ratio of from 0.005 to 1. Method for preventively or curatively combating the phytopathogenic fungi of crops by using this composition. ... 12/07/06 - 20060276518 - Aryl and heteroaryl compounds and methods to modulate coagulation This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway ... 12/07/06 - 20060276517 - Non-systemic control of parasites Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals. ... 11/30/06 - 20060270718 - Heterocyclic arylsulfonamidobenzylic compounds Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases. ... 11/23/06 - 20060264481 - Therapeutic modulation of ppargamma activity Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer. ... 11/23/06 - 20060264480 - Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same The present invention relates to an antagonist against vanilloid receptor and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, ... 11/02/06 - 20060247282 - Methods for using amino acids with affinity for the alpha2delta-protein This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. ... 10/26/06 - 20060241155 - Tnf-alpha production inhibitors wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively. ... 10/19/06 - 20060235057 - Phenyl compounds wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine. ... 10/12/06 - 20060229342 - Tnf-a production inhibitors wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively. ... 10/12/06 - 20060229341 - Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... 09/14/06 - 20060205794 - Phenethanolamine derivative for the treatment of respiratory diseases to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... 09/07/06 - 20060199850 - Insecticidal, acaricidal, and fungicidal nitromethylene compounds R2 is hydrogen or alkyl. The compositions are useful as insecticides, acaricides, and fungicides. ... 08/24/06 - 20060189665 - Oxamide derivatives useful as raf-kinase inhibitors The present invention relates to oxamide derivatives of Formula (I), the use of the compounds of Formula (I) as inhibitors of raf-kinase, the use of the compounds of Formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. ... 08/10/06 - 20060178410 - Aryl aniline beta2 adrenergic receptor agonists wherein R1-R13 and w have any of the values described in the specification. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds. ... 07/20/06 - 20060160866 - Anti-coronavirus compounds A method of treating coronavirus infection. The method includes administering to a subject suffering from or being at risk of suffering from such infection an effective amount of a compound of formula (I). Each variable in this formula is defined in the specification. ... 07/13/06 - 20060154972 - Amino acids with affinity for the alpha-2-delta-protein This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. ... 06/29/06 - 20060142352 - Compounds useful for the treatment of cancer, compositions thereof and methods therewith The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular ... 06/15/06 - 20060128765 - 2-(bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation Compounds disclosed herein are bradykinin B1 antagonist compounds useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... 06/15/06 - 20060128764 - Non-steroidal farnesoid x receptor modulators and methods for the use thereof The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR ... 06/08/06 - 20060122239 - Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... 06/08/06 - 20060122238 - Hydroxybenzoate salts of metanicotine compounds Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, ... 06/08/06 - 20060122237 - Hydroxybenzoate salts of metanicotine compounds Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, ... 05/25/06 - 20060111406 - Amide linker peroxisome proliferator activated receptor modulators The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I). ... 05/11/06 - 20060100252 - Aminoalcohol derivatives R9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence. ... 05/11/06 - 20060100251 - Substituted phenylalkanoic acids which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention ... 04/27/06 - 20060089394 - Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hppar activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... 04/27/06 - 20060089393 - Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors Compounds of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... 04/20/06 - 20060084686 - Methods of food intake management Methods for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The ... 04/06/06 - 20060074112 - N-aryl (thio) anthranilic acid amide derivatives, their preparation and their use as vegf receptor tyrosine kinase inhibitors Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R1 ... 04/06/06 - 20060074111 - Chemical compounds R6 is phenyl or a 6 membered heteroaryl group containing 1, 2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, —OC1-6 alkyl, —SO2C1-3 alkyl, phenyl (optionally substituted by one or ... 03/16/06 - 20060058359 - Compounds useful as pesticides Compounds useful to control pests are provided. ... 02/09/06 - 20060030603 - Novel aryl urea analogs and use thereof as antibacterial agents wherein R1A, R1B, R1C, R1D, X, Z, Q, R2A, R2B, R2C and R2D are as defined herein. Compositions comprising compounds of formulas (I) and (II) are also provided. ... 02/02/06 - 20060025456 - Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants processes for their preparation, pharmaceutical formulations comprising these compounds and the use of saturated and unsaturated heteroarylcycloalkylmethyl-amines for the preparation of pharmaceutical formulations. pharmaceutical formulations and related methods of treatment or prophylaxis of certain condition, especially depression and/or pain, are also disclosed. ... 01/19/06 - 20060014807 - Neuroprotective small organic molecules, compositions and uses related thereto The present application is directed to therapeutic compounds, compositions, and methods for culturing neuronal cells and for preventing and the treatment of neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS). ... 01/19/06 - 20060014806 - Dihalo-allyloxy-phenol derivatives having pesticidal activity Compounds of formula (I), wherein A1 and A2 are each independently of the other a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge; X1 and X2 are each independently of the other fluorine, chlorine or bromine; Y is O, NR7, S, SO or SO2; R1, R2 and R3 ... 01/19/06 - 20060014805 - Pesticidal fluoroalkene derivatives Pesticidal fluoroalkene derivatives (I) wherein A is oxygen, NRa; Ra is hydrogen; optionally halogenated alkyl, alkenyl, alkynyl; X is hydrogen, halogen; optionally halogenated alkyl or phenyl; R1,R2 are hydrogen, halogen, hydroxyl, cyano, nitro, mercapto, amino; alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkylthio, alkylamino, dialkylamino, alkoxycarbonyl, alkylcarbonyloxy, optionally halogenated or substituted by ... 01/12/06 - 20060009498 - Ophthalmic compositions and methods for treating ophthalmic conditions Compositions, and methods of using such compositions, useful for placement, for example injection, into the interior of human or animal eyes are provided. Such compositions include a therapeutic component, such as one or more corticosteroids, a biocompatible polymeric component, and a solvent component. The composition is in a fluid form ... 01/05/06 - 20060004063 - Inhibitors of hcv ns5b polymerase The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases. ... 01/05/06 - 20060004062 - Compounds for inhibiting insulin secretion and methods related thereto including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein. ... 12/29/05 - 20050288338 - Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor MR, and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or ... 12/22/05 - 20050282871 - 3-(3,5-disubstituted-4-hydroxyphenyl)propionamide derivatives as cathepsin b inhibitors The present invention is directed to novel 3-(3,5-disubstituted-4-hydroxyphenyl)-propionamide derivatives that are inhibitors of Cathepsin B. Pharmaceutical composition comprising these compounds, method of treating diseases mediated by Cathepsin B, utilizing these compounds and methods of preparing these compounds are also disclosed. ... 12/15/05 - 20050277681 - N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, ... 12/15/05 - 20050277680 - Compounds for treatment of cell proliferative diseases The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines. ... 12/08/05 - 20050272783 - Amino acids with affinity for the alpha2delta-protein This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric pain and other disorders. ... 12/01/05 - 20050267171 - Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... 11/17/05 - 20050256172 - Novel derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them are described wherein n is an integer from 1 to 4, R1 is a hydrogen atom, hydroxyl group or lower C1-6alkoxy group R2 is a hydrogen atom or a straight or branched lower C1-6alkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-Cl,2,4-di-Cl or lower C1-6alkoxy group, ... 11/10/05 - 20050250820 - Therapeutic modulation of ppargamma activity Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer. ... 11/03/05 - 20050245583 - 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives R7 is H, C1-C6alkyl, C1-C6alkoxyalkyl or C1-C6alkylcarbonyl; k, when D is nitrogen, is 1, 2 or 3; or, when D is CH, is 1, 2, 3 or 4; and m is 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in ... 10/27/05 - 20050239849 - Substituted phenoxyacetic acids Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis. ... 10/20/05 - 20050234110 - Novel 2-pyridylethylbenzamide derivative Compound of general formula (I) in which p is an integer equal to 1, 2, 3 or 4; q is an integer equal to 1, 2, 3, 4 or 5; each substituent X is chosen, independently of the others, as being halogen, alkyl or haloalkyl, at least one of the ... 10/20/05 - 20050234109 - Beta-amyloid protein production. secretion inhibitor and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them. ... 10/06/05 - 20050222217 - Non-systemic control of parasites Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals. ... 10/06/05 - 20050222216 - Carboxyoic acid compounds and drugs containing the compounds as the active ingredient (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound. Since the compound represented by formula (I) binds to a DP receptor and shows antagonistic activity for the DP receptor, it is useful for prevention and/or treatment of diseases such ... 10/06/05 - 20050222215 - Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors The present invention concerns the compounds having the formula (I), N-oxides, salt, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Haryl is an aromatic monocyclic, bicyclic or tricyclic heterocycle having 3 to 14 ring members which contains one or more heteroatom ring members selected from nitrogen, oxygen and ... 09/29/05 - 20050215601 - Therapeutic agent for rheumatic disease comprising benzamide derivative as active ingredient The present invention provides a method of treating rheumatic diseases comprising administering to a patient a pharmaceutically effective amount of a benzamide derivative or salts thereof. The benzamide derivative is a compound represented by the following general formula [1] or a salt thereof as an active ingredient. In the formula, ... 09/15/05 - 20050203149 - Insecticide containing hydrazone derivatives as the active ingredient and novel hydrazone derivates wherein A and Q are an aryl or a heterocyclic group, W is oxygen atom, an aminylene, an alkylene group, an oxyalkylene group or an alkyleneoxy, X1 and X2 are hydrogen atom, an alkyl, an alkenyl, an alkynyl, an aryl, a heterocyclic group, formyl, an acyl, an alkoxycarbonyl, an aryloxycarbonyl, ... 08/25/05 - 20050187265 - Novel benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides Rp3 are one to five identical or different radicals from the group consisting of: hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkoxyalkoxy, C1-C6-alkylcarbonyl; n is 0-5; p is, depending on the number of free valencies, 0-4. ... 08/25/05 - 20050187264 - Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative (wherein Ar1 represents substituted or unsubstituted pyridyl; Ar2 represents phenyl substituted by alkoxy, etc.; R1 represents hydrogen, alkyl, or aryl; R2 represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R3 represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each independently ... 08/18/05 - 20050182108 - Hetero-substituted acetanilide derivatives as analgesic agents Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever. ... 08/11/05 - 20050176784 - Malononitrile compounds and their use as pesticides The present invention relates to a novel malononitrile compound represented by the formula (I): wherein, R1 represents a C1 to C5 (halo)alkyl and the like, R2 represents a C1 to C5 (halo)alkyl, R3 and R4 are the same or different and are a C1 to C6 (halo)alkyl and the like, ... 06/23/05 - 20050137236 - Aminoalcohol derivatives R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence. ... 06/16/05 - 20050131034 - Compounds capable of activating cholinergic receptors Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine. ... 06/09/05 - 20050124669 - Methods for using amino acids with affinity for the alpha2delta-protein This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. ... 06/09/05 - 20050124668 - Amino acids with affinity for the alpha2delta-protein Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. ... ### FreshPatents.com Support |