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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms > Piperidines > Additional Ring Containing > The Additional Ring Is A Hetero Ring The Additional Ring Is A Hetero RingThe Additional Ring Is A Hetero Ring patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/11/07 - 20070010556 - Thiophene derivatives as chk 1 inhibitors This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer. ... 12/14/06 - 20060281788 - Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3. ... 12/07/06 - 20060276509 - Tripeptidyl peptidase inhibitors wherein n is an integer 0 or 1; X represents O; S; or —(CR4R5)m— wherein m is an integer 1 or 2; R4 and R5 are each independently from each other hydrogen or C1-4alkyl; R1 is C1-6alkylcarbonyl optionally substituted with hydroxy; C1-6alkyloxycarbonyl; aminoC1-6alkylcarbonyl wherein the C1-6alkyl group is optionally substituted ... 11/23/06 - 20060264470 - Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R11 are as defined herein. Further embodiments of the invention include a method of preparation of a compound of formula (I), its pharmaceutical composition and a method of treatment of a disease using a compound of formula (I). ... 11/23/06 - 20060264469 - Pharmaceutical composition for oral administration of a pyrazole-3-carboxamide derivative This invention discloses and claims a pharmaceutical composition in liquid or semi-liquid form, which is self-emulsifying or self-microemulsifying in aqueous medium, for the oral administration of a pyrazole-3-carboxamide derivative, in which said derivative is dissolved in an amphiphilic mixture containing one or more lipid solvents and a nonionic hydrophilic surfactant. ... 11/16/06 - 20060258709 - Combination of a cb1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity. ... 10/26/06 - 20060241146 - Nitrogen-containing 5-membered ring compound R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof. ... 10/26/06 - 20060241145 - Piperidine derivative crystal, process for producing the same, and use wherein each symbol is as defined in the specification, and a salt thereof. ... 10/26/06 - 20060241144 - Method for treating apathy syndrome The present invention provides a method of treating apathy syndrome in a human subject. The human subject is first evaluated to determine whether one or more behavioral characteristics of apathy are observed. If such characteristics are observed, the subject is treated with a 2-oxopyrrolidine compound, such as nefiracetam, piracetam, aniracetam, ... 10/26/06 - 20060241143 - Combination of paroxetine and 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2s-phenyl-piperidin-3s-yl)-amine for treatment of depression and/or anxiety The present invention relates to therapeutic combinations comprising paroxetine or physiologically acceptable salts or solvates thereof and 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)]-(2S-phenyl-piperidin-3S-yl)-amine or physiologically acceptable salts or solvates thereof, to pharmaceutical compositions containing said combinations and their use in the treatment of depression and/or anxiety. ... 09/21/06 - 20060211736 - Glutarimide-containing polyketide analogs and methods thereof The present invention provides library of glutarimide-containing polyketide analogs, such as analogs of migrastatin, iso-migrastatin, dorrigocin A and B, epi-dorrigocin, NK30424 A and B and lactimidomycin, methods of synthesizing and using these analogs and further methods of creating a combinatorial library of these compounds through chemical modifications. ... 09/14/06 - 20060205789 - Gacyclidine formulations Improved formulations of gacyclidine for direct administration to the inner or middle ear. ... 09/14/06 - 20060205788 - Compounds having activity at 5ht2c receptor and uses thereof wherein R1 is hydrogen, fluoro, chloro, hydroxy, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkyloxy, C1-6alkoxy or haloC1-6alkoxy; m is 0 when ═ is a double bond and m is 1 when ═ is a single bond; R2 is hydrogen, halogen, cyano, nitro, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkyloxy, haloC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, C1-6alkylthio, amino, mono- or di-C1-6alkylamino or ... 08/31/06 - 20060194843 - 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy). ... 08/24/06 - 20060189658 - Substituted pyrazoline compounds, their preparation and use as medicaments The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. ... 08/10/06 - 20060178403 - Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein m, n, X, R1, R2, R3, R4, and R5 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof. ... 07/27/06 - 20060167053 - Heteroarylcarbamoylbenzene derivative as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes and related conditions. Compositions and methods of treatment are also included. ... 07/27/06 - 20060167052 - Piperidine derivative, process for producing the same, and use wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally lo substituted imino ... 07/20/06 - 20060160857 - Thiazole-4-carboxyamide derivatives wherein R1 to R4 are as defined in the specification. ... 07/20/06 - 20060160856 - Diarylurea derivatives and their use as chloride channel blockers The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, ... 06/15/06 - 20060128754 - Tubulysins, method for producing the same and tubulysin preparations Z=(for Y=O or free electron pair) CH3 or (for Y=free electron pair) COR11. ... 06/08/06 - 20060122230 - 1,5-diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators The present invention relates to a compound of formula (I) in which R1 and R2 independently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; and R3 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, ... 06/08/06 - 20060122229 - 4,5-diarylthiazole derivatives as cb-1 ligands in which R1 and R2 independently represent phenyl, thienyl or pyridyl and R3 represents a group —X—Y—NR4R5 in which X is CO or SO2; Y is absent or represents NH and the other substituente are as defined in the description and their use in the treatment of obesity, psychiatric and ... 05/18/06 - 20060106068 - Sigma receptor inhibitors having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved. ... 04/27/06 - 20060089385 - Pharmaceutical compositions Forms and formulations of VX-950 and uses thereof. ... 04/20/06 - 20060084681 - Substituted pyrazoles, compositions containing such compounds and methods of use The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus. ... 03/30/06 - 20060069128 - N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes N-ureidoalkyl piperidines as modulators of chemokine receptors, or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... 03/30/06 - 20060069127 - Imidazolo-related compounds, compositions and methods for their use wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for ... 02/16/06 - 20060035935 - Acylated piperidine derivatives as melanocortin-4 receptor agonists Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual ... 02/02/06 - 20060025448 - Hair growth stimulators The present invention discloses method for modulating the growth of body and/or head/cranial hair on mammalian organisms, for example humans, by administering thereto, whether topically and/or systemically, therapeutically effective amounts of at least one cannabinoid ligands, in combination with or without other suitable therapeutically active agents. ... 01/26/06 - 20060019994 - I-sulphonlyl piperidine derivatives Piperidine derivatives of formula (1) that are useful in the inhibition of metalloproteinases, in particular TNF-α Converting Enzyme (TACE) and thus in the treatment of autoimmune disease, allergic/atopic diseases, transplant rejection, graft versus host disease, cardiovascular disease, reperfusion injury and malignancy. ... 01/19/06 - 20060014794 - Cxcr1 and cxcr2 chemokine antagonists useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease. ... 01/05/06 - 20060004055 - Derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n-(piperidine-1-yl)-1h-pyrazole-3-carboxamide, the preparation and therapeutic use thereof Preparation process and therapeutic use. ... 12/15/05 - 20050277677 - Method for treating emesis with ghrelin agonists R4 is H or CH3; or a pharmaceutically acceptable salt or solvate thereof, in an amount that is effective in treating nausea, emesis, or symptoms associated therewith in said patient. ... 12/15/05 - 20050277676 - M3muscarinic acetylcholine receptor antagonists M3 Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... 12/08/05 - 20050272776 - Compositions containing opioid antagonist Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having ... 11/17/05 - 20050256167 - Preparation and use of imidazole derivatives for treatment of obesity This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders. ... 11/17/05 - 20050256166 - Nitrogen-containing compounds wherein ring A represents a nitrogen containing heterocyclic ring, ring B represents 5-membered heterocyclic ring which may have substituents, R represents a hydrogen atom or cyano and the other symbols represent as described in the specification; or a salt thereof. The compound represented by formula (I) has an inhibitory activity ... 11/03/05 - 20050245576 - Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described. ... 11/03/05 - 20050245575 - 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included. ... 10/27/05 - 20050239843 - Diaminothiazoles are discussed. These compounds selectively inhibit the activity of Cdk4 and are thus useful in the treatment or control of cancer, in particular, the treatment or control of solid tumors. This invention also provides pharmaceutical compositions containing such compounds and methods of treating or controlling cancer, most particularly, the treatment ... 09/15/05 - 20050203143 - Novel compounds as opioid receptor modulators The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors. ... 08/25/05 - 20050187253 - Medicinal kit to quit tobacco consumption comprising central cannabinoid receptor antagonist The invention relates to the use of a medicinal kit comprising N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide for helping to quit tobacco consumption. ... 08/25/05 - 20050187252 - Novel compounds as opioid receptor modulators This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders. ... 08/11/05 - 20050176772 - Pharmaceutically active compounds wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. ... 08/11/05 - 20050176771 - 2-cyano-4-fluoropyrrolidine derivative or its salt Provided is a compound having excellent dipeptidyl peptidase IV-inhibiting activity, and a remedy based on the activity for insulin-dependent diabetes (type 1 diabetes), especially for non insulin-dependent diabetes (type 2 diabetes), insulin-resistant disorders, and obesity. ... 08/04/05 - 20050171161 - Method of treatment or prevention of obesity The present invention relates to a method of treating or preventing obesity (or suppressing the appetite) in a human patient by antagonizing CB1 receptors and inhibiting the enzyme 11β-HSD1 in an amount that is effective to treat or prevent obesity. Compounds useful in the present invention have an ion channel ... 07/21/05 - 20050159453 - Novel methods for the treatment and prevention of ileus Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaterary benzomorphans. The methods are particularly suitable for ... 07/14/05 - 20050154024 - Compounds useful in therapy Het6 represents an optionally substituted 5- or 6-membered saturated, partially saturated or aromatic heterocyclic ring; are useful for treating a disorder for which a V1a antagonist is indicated. ... 06/30/05 - 20050143421 - Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives. ... 06/16/05 - 20050131025 - Amelioration of cataracts, macular degeneration and other ophthalmic diseases R7 is C1 to C6 alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl or where R6 and R7, or R5, R6 and R7, taken together, form a carbocycle or heterocycle having from 3 to 7 atoms in the ring. ... 06/09/05 - 20050124660 - Novel medical uses of compounds showing cb1-antagonistic activity and combination treatment involving said compounds The present invention relates to a novel medical use of compounds with CB1-receptor activity selected from the group of 4,5-dihydro-1H-pyrazole derivatives, 1H-Imidazole derivatives, thiazole derivatives and/or 1H-1,2,4-triazole-3-carboxamide derivatives, as each defined in the specification, or of a prodrug thereof, a tautomer thereof or a salt thereof, in the manufacture of ... ### FreshPatents.com Support |