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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms > Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos > Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos > Tropanes (including Nor Or Dehydro Form) Tropanes (including Nor Or Dehydro Form)Tropanes (including Nor Or Dehydro Form) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/18/07 - 20070015789 - Novel methods using aminobenzoic acid compounds The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be ... 01/18/07 - 20070015788 - Chemical compounds Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal). ... 01/11/07 - 20070010550 - Scopolamine to reduce or eliminate hot flashes, night sweats, and insomnia Compositions and methods of treating or preventing hot flashes, night sweats, and/or insomnia in a subject that involve scopolamine are disclosed. For example, methods of treating hot flashes, night sweats, and/or insomnia in a subject that involve transdermal delivery of scopolamine are set forth herein. ... 10/19/06 - 20060235044 - Azabicyclononene derivatives The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as ... 10/12/06 - 20060229332 - Crystalline form of a quinolinone-carboxamide compound The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salt forms. ... 10/05/06 - 20060223846 - Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists and pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and, in particular, α4β1 and α4β7 integrin receptor antagonists. The invention is further directed to methods for use of the instant compounds for treating integrin mediated disorders including, but not limited to, inflammatory disorders, autoimmune disorders and ... 09/28/06 - 20060217414 - High affinity ligands for nociceptin receptor orl-1 or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of anxiety are disclosed. ... 09/14/06 - 20060205769 - Piperidine or 8-aza-bicyclo[3.2.1]oct-3-yl derivatives useful as modulators of chemokine receptor activity Compounds of formula (I): wherein R1, R2, R3, R4, A and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal). ... 09/14/06 - 20060205768 - Tropane derivatives and their use as ace inhibitors The invention relates to novel tropane derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as ... 09/07/06 - 20060199839 - Quinolinone compounds as 5-ht4 receptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. ... 09/07/06 - 20060199838 - Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's ... 08/31/06 - 20060194834 - Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment. ... 08/24/06 - 20060189651 - Combinations comprising antimuscarinic agents and beta-adrenergic agonists Combinations comprising (a) a β2 agonist and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid are useful, e.g., for the treatment of respiratory disease, e.g., asthma ... 08/24/06 - 20060189650 - Novel piperidine derivatives as modulators of chemokine receptor ccr5 Compounds of formula (I) wherein R1, R2R3, R4, Λ, X, m and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy them and their use in medical therapy (for example mod ulating CCR5 receptor activity in a warm blooded animal). ... 08/17/06 - 20060183769 - Benzoxazole carboxamides for treating cinv and ibs-d are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D. ... 08/10/06 - 20060178396 - Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... 08/10/06 - 20060178395 - Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... 08/03/06 - 20060173037 - Aminophenyl derivatives as selective androgen receptor modulators wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto. ... 07/20/06 - 20060160845 - Aminophenyl derivatives as selective androgen receptor modulators wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto. ... 07/20/06 - 20060160844 - Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... 07/06/06 - 20060148847 - Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclo[[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. ... 06/29/06 - 20060142331 - Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. ... 06/08/06 - 20060122220 - Method for treating hiv infection through co-administration of tipranavir and uk-427,857 A method for treating HIV infection through co-administration of tipranavir and UK-427,857. ... 06/08/06 - 20060122219 - Use of flumazenil in the production of a medicament for the treatment of cocaine dependency The invention relates to the use of flumazenil to produce a medicament for the treatment of cocaine dependency. The flumazenil can be administered sequentially in small quantities at short intervals until a therapeutically effective quantity for the treatment of cocaine dependency has been administered. ... 06/08/06 - 20060122218 - 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. ... 06/01/06 - 20060116395 - 1h-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved. ... 05/11/06 - 20060100236 - 5-ht4 receptor agonist compounds The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. ... 03/30/06 - 20060069120 - Novel piperidine derivaties as modulators of chemokine receptor ccr5 Compounds of formula (I): wherein R1, R2, R3, R4, R5, A and X are as defined herein; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal). ... 03/16/06 - 20060058344 - Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions wherein X− and the groups A, B, R, R1, R2, R3, R3′, R4, R4′, Rx and Rx′ may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions. ... 03/16/06 - 20060058343 - Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols c) optionally converting a compound of formula I wherein R is benzyl, R5-benzyl, allyl, —C(O)R6 or —C(O)OR6 to a compound of formula I wherein R is —CH(R7)2. Intermediates in the process are also claimed. ... 03/09/06 - 20060052413 - Novel piperidine derivatives as modulators of chemokine receptor ccr5 Compounds of formula (I): wherein R1, R2, R3, R4, n, A and X are defined above; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal). ... 03/02/06 - 20060046995 - Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents. ... 02/09/06 - 20060030585 - Tricyclic delta-opioid modulators The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described. ... 01/26/06 - 20060019983 - Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV ... 01/26/06 - 20060019982 - Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV ... 01/19/06 - 20060014780 - Nicotinamide derivatives useful as pde4 inhibitors The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders ... 12/15/05 - 20050277664 - Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid generation The invention relates to the use of a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety for the preparation of a medicament for inhibiting β-amyloid generation. ... 10/27/05 - 20050239824 - Triple monoamine reuptake inhibitors for the treatment of chronic pain The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain. ... 10/13/05 - 20050228014 - Quinolinone-carboxamide compounds as 5-ht4 receptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. ... 09/15/05 - 20050203124 - Compounds for the sustained reduction of body weight The invention relates to the use of a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof for a medicament for the for the sustained reduction of body weight. ... 09/15/05 - 20050203123 - Substituted piperidine compounds and methods of their use Certain 4-aryl-piperidine compounds, including N-substituted 9β-substituted-5-(3-substituted-phenyl)morphans and N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines, pharmaceutical compositions, and methods of their use, inter alia, as opioid antagonists are disclosed. ... 09/08/05 - 20050197360 - Cocaine receptor binding ligands A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for ... 08/18/05 - 20050182090 - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist The invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one dopamine agonist or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof. ... 08/18/05 - 20050182089 - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist Accordingly, the invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one NMDA receptor antagonists or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof. ... 08/11/05 - 20050176755 - Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists and pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and, in particular, α4β1 and α4β7 integrin receptor antagonists. The invention is further directed to methods for use of the instant compounds for treating integrin mediated disorders including, but not limited to, inflammatory disorders, autoimmune disorders and ... 08/04/05 - 20050171145 - Process for the preparation of 2-(ethoxymethyl)-tropane derivatives The present invention relates to a process for preparing a 2-(ethoxymethyl)-tropane derivative or a pharmaceutically acceptable salt thereof, by reacting the corresponding 2-(hydroxymethyl)-tropane derivative with ethyl bromide in the presence of a base, and a phase transfer catalyst. ... 07/14/05 - 20050154009 - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor The invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one acetylcholinesterase inhibitor or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and a ... 06/23/05 - 20050137225 - Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands The present invention discloses novel cholinergic receptor ligands. The present invention also relates to the synthesis of substituted derivatives of aza-bridged bicyclic amines for use as muscarinic receptor ligands as well as methods of regulating function of certain cholinergic receptors, and hence acting as antagonists, agonists and partial agonists at ... 06/23/05 - 20050137224 - 2-cyanopyrrolidinecarboxamide compound R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.]having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM. ... 06/09/05 - 20050124651 - Solid pharmaceutical preparation The invention relates to a solid pharmaceutical preparation containing one or more solid carriers and/or excipients and an active substance selected from among the Monoamine Neurotransmitter Re-uptake Inhibitors which have a 2,3-disubstituted tropane structure, the preparation thereof and use thereof for preparing a pharmaceutical composition for the treatment or prevention ... 06/09/05 - 20050124650 - Process for preparing a pharmaceutically active compound (granisetron) The invention relates to a process for preparing granisetron, or a pharmaceutically acceptable salt thereof, which comprises: a) cyclisation of a compound of formula (I) in an inert solvent and at a temperature between 0-100° C., in the presence of a strong acid, in order to yield the compound of ... ### FreshPatents.com Support - Terms & Conditions |