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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon Atoms Hetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon AtomsHetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon Atoms patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.02/01/07 - 20070027155 - Biaryl piperazinyl-pyridine analogues wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods ... 02/01/07 - 20070027154 - Insecticide for agricultural or horticultural use and method of use thereof The compounds represented by formula (1) exhibit an excellent preventive effect as insecticides and also exhibit an excellent preventive effect when being combined with another insecticide, an acaricide, a nematocide, a fungicide, a herbicide, a plant growth regulator, or a biological pesticide. ... 01/25/07 - 20070021424 - Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics. ... 01/25/07 - 20070021423 - Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions. ... 01/25/07 - 20070021422 - Prokineticin 1 receptor The present invention relates to methods of monitoring the biological activity of the PK1 receptor. ... 01/18/07 - 20070015758 - Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism. ... 01/18/07 - 20070015757 - Novel glucagon antagonists/inverse agonists Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists. ... 01/18/07 - 20070015756 - Chemical compounds Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. ... 01/04/07 - 20070004729 - Methods and compositions of novel triazine compounds The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that ... 01/04/07 - 20070004728 - Method of synthesis of azole-containing amino acids The invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method. ... 01/04/07 - 20070004727 - Use of compounds for the prevention of drug-induced cell toxicity The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment the compounds have at least ... 12/28/06 - 20060293325 - Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments where Z is an amine, alcohol, or thiol-containing group, and Y is an alkyl-containing amine. Methods of producing such compounds and using them to treat patients with diabetes and obesity are also disclosed. The present invention also relates to treating such conditions with GADPH inhibitors and screening compounds useful for ... 12/21/06 - 20060287320 - Preparation of thioarabinofuranosyl compounds and use thereof wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells. ... 12/21/06 - 20060287319 - Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds A group of compounds that inhibit HIV replication by blocking HIV entry was identified. One representative compound, designated NB-206, and its analogs inhibited HIV replication (p24 production) with IC50 values at nanomolar levels. It was proved that NB-206 and its analogs are HIV entry inhibitors by targeting the HIV gp41 ... 12/21/06 - 20060287318 - Method for treating glaucoma iii b Provided, among other things, is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing or ocular accommodation improving amount of a compound of the formula (1): Y-Ar⊕•X− ... 12/07/06 - 20060276474 - Novel carboxylic acid derivatives, their preparation and use where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ... 12/07/06 - 20060276473 - Use and administration of bacterial efflux pump inhibitors This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial, and novel medical methods. ... 11/23/06 - 20060264437 - Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline as 5-ht1a antagonists are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia, and are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such eating disorders, disorders of thermoregulation, ... 11/16/06 - 20060258657 - Apoptosis promoters Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member. ... 11/09/06 - 20060252754 - Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds ... 11/02/06 - 20060247242 - Pesticidal compositions or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof, processes for their preparation, and methods for their use for the control of arthropods (including insects and arachnids) and helminths (including nematodes). ... // - 5-Substituted-sulfonylaminopyrazole derivatives of formula (I): - ... 10/26/06 - 20060241113 - Polyarylcarboxamides useful as lipid lowering agents are useful as lipid lowering agents. ... 10/19/06 - 20060235018 - Prokineticin 1 receptor antagonists and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders. ... 10/12/06 - 20060229310 - Antibacterial compounds Antibacterial compounds, processes for making them and intermediates used in the processes, compositions containing them, and methods for treatment of bacterial infections using them are disclosed. ... 10/05/06 - 20060223806 - Microbicidal composition based on formaldehyde donor compounds and antioxidants Microbicidal composition for product preservation, including a microbicidal composition which comprises a) at least one formaldehyde donor compound and b) at least one antioxidant chosen from gallic esters, phenol derivatives, L-ascorbic acid, and salts and derivatives thereof, and tocopherols and derivatives thereof, and to the use thereof for the preservation ... 10/05/06 - 20060223805 - Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics Wherein n, A, R1, R2, and R3 are as defined herein. The invention also relates to methods of preparation of compound of formula (I) as well as its use in therapeutics. ... 10/05/06 - 20060223804 - Nk1 antagonists or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough. ... 10/05/06 - 20060223803 - Process for resolving aimines that are useful for the treatment of disorders associated with insulin resistance syndrome The present invention is directed towards a process for resolving a racemic amino compound derived from dihydro-1,3,5-triazines. The invention is also directed towards the enantiomers of amino derivatives of dihydro-1,3,5-triazines and to their use for the preparation of medicaments, in particular for the treatment of diabetes and malaria. ... 09/21/06 - 20060211694 - Diaryl substituted pyridinones and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using ... 08/31/06 - 20060194802 - Phenylamino isothiazole carboxamidines as mek inhibitors The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones. ... 08/24/06 - 20060189614 - Substituted diamino-1,3,5-triazine derivatives the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido ... 08/24/06 - 20060189613 - Sulphonamide compounds that modulate chemokine receptor activity (ccr4) The invention provides pyrimidine, pyridazine and triazine compounds for use in therapy. ... 08/17/06 - 20060183743 - Kappa opioid receptor ligands Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions. ... 08/10/06 - 20060178367 - Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof and pharmaceutically acceptable salts, solvates, crystal forms, chelates, non-covalent complexes, prodrugs, and mixtures thereof, are described herein. Pharmaceutical compositions comprising at least one chemical entity of Formula 1, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from ... 07/20/06 - 20060160808 - New carboxylic acid derivatives, their preparation and their use pharmaceutically acceptable salts and enantiomers thereof and pharmaceutical compositions containing this compound, its pharmaceutically acceptable salts and enantiomers are claimed. ... 07/20/06 - 20060160807 - Selective inhibitors of erk protein kinase and uses thereof Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer. ... 07/20/06 - 20060160806 - Ureas having antiangiogenic activity are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds. ... 07/13/06 - 20060154928 - Novel 2,4-diamino-1,3,5-triazine derivative or a pharmaceutically acceptable salt thereof. ... 06/29/06 - 20060142291 - Use of formaldehyde and formaldehyde-releasing compounds in a composition for controlling mycobacteria The invention relates to the use of a bactericide selected from formaldehyde and formaldehyde-releasing compounds in a composition for controlling mycobacteria, for example in a cooling lubricant. ... 06/22/06 - 20060135522 - Tricyclic delta-opioid modulators The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described. ... 06/15/06 - 20060128706 - Apoptosis promoters Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member. ... 06/08/06 - 20060122183 - Taxol enhancer compounds R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions ... 06/01/06 - 20060116377 - Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but ... 05/25/06 - 20060111353 - Substituted arylcyclopropylacetamides as glucokinase activators According to the present invention there is provided a compounds of formula (I): and pharmaceutically acceptable salts thereof. ... 05/11/06 - 20060100209 - Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations. ... 05/11/06 - 20060100208 - Pyrazole derivatives as cannabinoid receptor antagonists One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and ... 05/04/06 - 20060094721 - Sulfonamides as potassium channel blockers Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated ... 04/20/06 - 20060084649 - Substituted alkyl amido piperidines This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective ... 03/16/06 - 20060058301 - Modulators of ppar and methods of their preparation The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases ... 02/16/06 - 20060035896 - Lpaat-beta inhibitors and uses thereof The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPMT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity. ... 02/09/06 - 20060030563 - Novel pyrazole analogs acting on cannabinoid receptors One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and ... 01/26/06 - 20060019956 - Compositions useful as inhibitors of rock and other protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. ... 01/12/06 - 20060009453 - Protein kinase modulators and method of use wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes ... 01/05/06 - 20060004005 - Triazines derivatives as cell adhesion inhibitors The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, ... 12/15/05 - 20050277642 - Pyrimidine kinase inhibitors As selective inhibitors of inappropriate kinase activities, the compounds of the present invention are useful in the treatment of conditions associated with such activity, including, but not limited to, inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting ... 12/15/05 - 20050277641 - 2,4-disubstituted triazine derivatives the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein −a1=a2−a3=a4—forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each ... 12/01/05 - 20050267110 - Propane-1, 3-dione derivative Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect. ... 12/01/05 - 20050267109 - Pyridyl-triazine derivatives as microbiocidal active substances Triazine derivatives of formula (1) wherein R1 is C1-C20alkyl; C3-C7cycloalkyl; or C1-C20perfl C1-C20alkyl; or C3-C7cycloalkyl; and R3 is hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C1-C20perfluoroalky; C1-C20alkyl-carbonyl; C3-C7cycloalkyl-carbonyl; C1-C20perfluoroalkyl-carbonyl; or phenylcarbonyl; are described. The compounds exhibit pronounced action against gram-positive and gram-negative bacteria and also against yeasts and moulds. They are also suitable for ... 11/24/05 - 20050261293 - Compounds which inhibit leukocyte adhesion mediated by vla-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, ... 11/24/05 - 20050261292 - Pharmaceutical composition containing n-sulfamoyl-n'-arylpiperazines for the treatment or inhibition of obesity and related conditions and their physiologically compatible acid addition salts for the treatment or inhibition of obesity and related conditions. ... 11/17/05 - 20050256121 - Substituted 2,5-heterocyclic derivatives The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: ... 11/03/05 - 20050245523 - Heteroaryl derivatives and their use as medicaments The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... 10/13/05 - 20050227984 - Drugs for improving the prognosis of brain injury and a method of screening the same Brain injury in which prostaglandin D2 is participated is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by inhibition of activation of prostaglandin D receptor ... 10/13/05 - 20050227983 - Triazine compounds and their analogs, compositions, and methods The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory ... 10/06/05 - 20050222152 - New use of pyrimidine - or triazine - 2 carbonitiles for treating diseases associated with cysteine prostease activity and novel pyrimidine-2-carbonitile derivatives The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also ... 09/22/05 - 20050209234 - 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds R4 and R5 each represent hydrogen, or are adjacent and, together with the carbon atoms carrying them, form a benzo ring, Ar represents aryl or heteroaryl. Medicinal products containing the same which are useful as thrombin inhibitors. ... 09/08/05 - 20050197338 - Substituted pyrazole urea compounds for the treatment of inflammation wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed. ... 08/11/05 - 20050176709 - Selective npy (y5) antagonists This invention is directed to triazine derivatives, bicyclic compounds and tricyclic compounds which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made ... 08/04/05 - 20050171105 - Methods and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, ... 08/04/05 - 20050171104 - Novel thyroid receptor ligands This invention relates to novel compounds according to the general formula: which are thyroid receptor ligands, preferably antagonists, partial antagonists or partial agonists and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyro-toxicosis, subclinical hyperthyrodism and liver diseases. ... 07/28/05 - 20050165022 - Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. The compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome. ... 07/28/05 - 20050165021 - Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases. ... 07/28/05 - 20050165020 - 3-heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides R1-R7 are hydrogen, alkyl or haloalkyl; Y is unsubstituted or substituted aryl, or benzo[1,4]dioxonyl, benzo[1,3]dioxolanyl, 2,3-dihydrobenzofuranyl or benzimidazole; or unsubstituted or substituted 5- to 6-membered heteroaryl; and their agriculturally useful salts, processes and intermediates for their preparation, and the use of these compounds or of the compositions comprising these compounds ... // - 3-Heteroaryl-substituted isoxazolines of the formula I - ... 07/14/05 - 20050153965 - Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade. ... 06/23/05 - 20050137197 - 1h-imidazole derivatives as cannabinoid receptor modulators wherein R, R1-R4 and X have the meanings given in the specification. ... 06/23/05 - 20050137196 - Medical devices employing triazine compounds and compositions thereof The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that ... 06/16/05 - 20050130969 - 4'-thio-l-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; ... 06/16/05 - 20050130968 - Fungicidal 4-(2-aminopyridin-4-yl)-n-phenyl-1,3,5-triazin-2-amine derivatives The present invention relates to triazine derivatives, especially 4-(2-aminopyridin-4-yl)-N-phenyl-1,3,5-triazin-2-amine derivatives and their use as fungicidal compositions. Novel compounds showing fungicidal activity are disclosed and further, novel compositions containing 4-(2-aminopyridin-4-yl)-N-phenyl-1,3,5-triazin-2-amine derivatives can be used in fungicide applications. ... 06/09/05 - 20050124619 - Medical devices employing triazine compounds and compositions thereof The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that ... ### FreshPatents.com Support |