REGISTER now for FREE 
|
FREE patent keyword monitoring and additional FREE benefits. REGISTER now for FREE
|
|
|
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered And Includes At Least Nitrogen And Oxygen As Ring Hetero Atoms (e.g., Monocyclic 1,2- And 1,3-oxazines, Etc.) > Morpholines (i.e., Fully Hydrogenated 1,4- Oxazines) > Additional Hetero Ring Attached Directly Or Indirectly To The Morpholine Ring By Nonionic Bonding > Ring Nitrogen In The Additional Hetero Ring Ring Nitrogen In The Additional Hetero RingRing Nitrogen In The Additional Hetero Ring patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/25/07 - 20070021420 - New derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments in racemic or enantiomeric form. ... 01/25/07 - 20070021419 - 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors Z is CR10 and R7-9 are all H, R10 is other than OCF2CHF2. ... 01/25/07 - 20070021418 - Method of inhibiting production of osteopontin A means a single bond, a C1-6 linear or branched alkylene group, or a C2-9 linear or branched alkenylene group; and X means an oxygen atom or a sulfur atom. ... 01/18/07 - 20070015754 - Acyl guanidines as beta-secretase inhibitors or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is ... 01/11/07 - 20070010516 - Novel piperidine derivatives The invention relates to novel piperidine derivatives and related compounds of General Formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and ... 01/04/07 - 20070004723 - Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof The present invention relates to substituted diphenyl heterocycle compounds having an oxadiazole moiety and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections. ... 01/04/07 - 20070004722 - 1,2,4-thiadazole compounds and use thereof The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R2?, C4-C7 straight alkenylene optionally substituted with one to four of R2?, ethylene-oxy-ethylene optionally substituted ... 12/28/06 - 20060293324 - Pyrimidine compounds This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject in need thereof an effective amount of one or more compounds of formula (I). Each variable in this formula is defined in the ... 12/21/06 - 20060287315 - Pyrazinedicarboxamides and their use The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders. ... 12/14/06 - 20060281748 - Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or preventive therapy. This method involves administering a composition containing a therapeutically effective amount of a ROS inhibitor to ... 11/30/06 - 20060270674 - Pharmaceutical composition promoting defecation The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof. ... 11/23/06 - 20060264435 - Novel compounds The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. ... 11/16/06 - 20060258656 - Compositions and methods for treating cancer Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents. ... 11/02/06 - 20060247241 - 2,4-di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders to process for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them ... 10/26/06 - 20060241112 - Kinase inhibitors or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula I is also described. ... 10/19/06 - 20060235017 - Cytokine inhibitors Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful ... 09/28/06 - 20060217380 - Heteroaryl-substituted alkyne compounds and method of use wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation ... 09/28/06 - 20060217379 - 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity. ... 09/21/06 - 20060211693 - Cis-imidazolines wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity. ... 09/14/06 - 20060205725 - Method for treating ocular hypertension and glaucoma Provided is a method for treating ocular hypertension and glaucoma with reduced side effects such as keratoconjunctive disorders and macular edema, which comprises administering an ophthalmic composition comprising latanoprost as an active ingredient thereof to a subject in need of said treatment, wherein the ophthalmic composition contains substantially no benzalkonium ... 09/14/06 - 20060205724 - Antagonizing nk-1 receptors inhibits consumption of substances of abuse This invention pertains to the surprising discovery that administration of one or more NK1 receptor antagonists to a mammal can inhibit self-administration of a substance of abuse (e.g. alcohol). In one embodiment, this invention provides a method of inhibiting or reducing self-administration of a substance of abuse by a mammal. ... 09/07/06 - 20060199821 - Heterocyclic amides and sulfonamides The invention is directed to compounds and methods to inhibit p38 kinase wherein the compounds are a pyrimidine or pyridine coupled to two mandatory substituents. ... 09/07/06 - 20060199820 - Human adam-10 inhibitors The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to ... 08/17/06 - 20060183742 - Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours. ... 08/10/06 - 20060178365 - Novel sulfamides The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists. ... 08/03/06 - 20060173004 - 1-(4-benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases. ... 07/27/06 - 20060166988 - Novel compounds The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred. ... 07/27/06 - 20060166987 - Opioid receptor antagonists A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed. ... 07/27/06 - 20060166986 - Novel stereoselective synthesis of benzimidazole sulfoxides The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazol is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5-(and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- ... 07/20/06 - 20060160804 - Novel pyridazine derivatives and medicines containing the same as effective ingredients wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) ... 07/20/06 - 20060160803 - Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases. ... 07/20/06 - 20060160802 - Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... 07/20/06 - 20060160801 - Pyrimidinone derivaties as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases. ... 06/29/06 - 20060142284 - Novel compounds The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to a nilinopyrazole derivatives useful as CDK2 inhibitors and use of the anilinopyrazoles in the treatment of ... 06/22/06 - 20060135519 - 5-aryltetrazole compounds and compositions thereof ABSTRACT5-ARYLTETRAZOLES COMPOUNDS AND COMPOSITIONS THEREOFThe present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a 5-Arytetrazole Compound, and methods for treating an inflammation disease, a reperfusion disease, or hyperuricemia in an animal in need thereof comprising administering to the animal an effective amount of a 5-Aryltetrazole compound. ... 04/27/06 - 20060089356 - Substituted imidazoles as cannabinoid receptor modulators The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) ... 04/13/06 - 20060079524 - Amino substituted aryloxybenzylpiperidine derivatives This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically ... 04/06/06 - 20060074085 - N-sulfonylurea apoptosis promoters are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... 03/30/06 - 20060069096 - Pyrazolo[3,4-e]benzoxazoles for the treatment of glaucoma Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed. ... 02/23/06 - 20060040937 - N-aroyl cyclic amines as orexin receptor antagonists This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals. ... 02/02/06 - 20060025415 - Compositions useful as inhibitors of voltage-gated sodium channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... 02/02/06 - 20060025414 - Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists wherein P, Q, X1, X2, X3, X4 X5, X6, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of ... 01/26/06 - 20060019953 - Pyridine inhibitors of erk2 and uses thereof The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. ... 01/26/06 - 20060019952 - Anti-viral therapeutics Heterocyclic compounds of formula (I), (II), (III), and (IV) and methods of treating or preventing an HIV-mediated disorder by administering a compound of formula (I), (II), (III), or (IV) are described herein. ... 01/26/06 - 20060019951 - Vacuolins The present invention provides compositions and methods relating to vacuolins and their uses. Vacuolins are small molecule agents that affect certain membrane fusion events involving intracellular compartments. The invention further provides compositions and methods for altering antigen presentation mediated by class II MHC molecules, and/or for inhibiting histamine release from ... 12/29/05 - 20050288287 - Chiral cis-imidazolines and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity. ... 12/22/05 - 20050282809 - Heteroaryl-hydrazone compounds or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is —C(Rg)═N-A. The invention also relates to methods of treating IL-12 overproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a ... 12/15/05 - 20050277640 - Pyrimidine derivatives for treatment of hyperproliferative disorders in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative ... 11/24/05 - 20050261291 - 1,2-di(cyclic)substituted benzene compounds wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc. ... 11/17/05 - 20050256120 - Heterocyclo-substituted imidazoles for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (V), wherein R3 is a radical selected from hydrido, alkyl, haloalkyl, aralkyl, heterocycloalkyl, heteroaralkyl, acyl, cyano, alkoxy, alkylthio, alkylthioalkyl, alkylsulfonyl, cycloalkylthio, cycloalkylthioalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, haloalkylsulfonyl, arylsulfonyl, halo, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, ... 11/03/05 - 20050245521 - Novel benayl(idene)-lactam derivatives wherein R1, R3, R6, R13 X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the ... 11/03/05 - 20050245520 - 2-phenylpyridin-4-yl derivatives as alk5 inhibitors This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment ... 10/13/05 - 20050227981 - Aralkyl and aralkylidene heterocyclic lactam and imides wherein R1, R2, R3, X, Y and the dashed line are as defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents. ... 10/13/05 - 20050227980 - Aralkyl and aralkylidene heterocyclic lactam and imides wherein R1, R2, R3, X, Y and the dashed line are as defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents. ... 10/06/05 - 20050222151 - Non-imidazole heterocyclic compounds Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... 10/06/05 - 20050222150 - 6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect ... 09/29/05 - 20050215551 - 1-[2h-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders wherein the symbols have the meanings as given in the description. ... 09/29/05 - 20050215550 - Pyrazole-derived kinase inhibitors and uses thereof where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease. ... 09/22/05 - 20050209233 - Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described. ... 09/22/05 - 20050209232 - Pyridazinone ureas as antagonists of alpha4 integrins methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated disorders. More particularly, the pyridazinone urea compounds of the present invention are α4β7 integrin inhibitors useful for treating integrin mediated disorders. ... 09/22/05 - 20050209231 - Compositions and methods for inducing cardiomyogenesis The present invention provides compositions and methods for inducing cardiomyogenesis in mammalian cells, particularly embryonic stem cells, in vitro and in vivo. ... 09/22/05 - 20050209230 - 2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized ... 09/15/05 - 20050203092 - 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention ... 09/08/05 - 20050197337 - Aminomethylpyrimidines as allosteric enhancers of the gabab receptors It has been found that the compounds of the invention are active on the GABAB receptor and therefore are useful for the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated ... 09/08/05 - 20050197336 - Inhibitors of histone deacetylase Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC. ... 08/25/05 - 20050187218 - Imidazole based kinase inhibitors and their use for the treatment of cancer. ... 08/04/05 - 20050171102 - Semicarbazide derivatives for combating thromboembolic diseases Novel compounds of the formula I in which R, R1, R1, X are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours. ... 07/28/05 - 20050165019 - Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suitable for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on ... 07/28/05 - 20050165018 - Retinoic acid mimetic anilides the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S or NR3; R1 represents hydrogen, hydroxy, C1-6alkyl or aryl; R2 represents hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl; aryl; Het1; or R1 and R2 taken together may form a bivalent radical of formula ... 07/28/05 - 20050165017 - Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use. ... 07/28/05 - 20050165016 - Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein t, R1, R2, L, Q, X, Y, Z and (a) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ... 07/21/05 - 20050159418 - 5-aryltetrazoles compounds and compositions thereof The present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a a 5-Aryltetrazole Compound, and methods for treating an inflammation disease, a reperfusion disease, or hyperuricemia in an animal in need thereof comprising administering to the animal an effective amount of a 5-Aryltetrazole compound. ... 07/14/05 - 20050153964 - Novel compounds are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. In Formula I R1, R2, R3, R4, R5, R6, X and Y are as defined herein. ... 06/30/05 - 20050143378 - Treatment of conditions through pharmacological modulation of the autonomic nervous system Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is pharmacologically modulated with at least one beta-blocker in a manner that is effective ... 06/23/05 - 20050137195 - Polymorphs Disclosed are polymorphs of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea and processes from making the same. ... 06/16/05 - 20050130967 - 3-substituted-4-pyrimidone derivatives wherein R2 and R3 independently represent a hydrogen atom or a C1-C8 alkyl group; R4 represents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring ... 06/02/05 - 20050119262 - Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent The present invention provides methods and compositions for the prevention and/or treatment of an optic neuropathy, comprising a Cox-2 inhibitor and an intraocular pressure reducing agent. ... 06/02/05 - 20050119261 - Biaryl substituted triazoles as sodium channnel blockers Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and ... ### FreshPatents.com Support |