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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered And Includes At Least Nitrogen And Oxygen As Ring Hetero Atoms (e.g., Monocyclic 1,2- And 1,3-oxazines, Etc.) > Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., Maytansinoids, Etc.) > Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., 1,4-benzoxazines, Etc.) Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., 1,4-benzoxazines, Etc.)Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos (e.g., 1,4-benzoxazines, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.02/01/07 - 20070027148 - New enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints. ... 02/01/07 - 20070027147 - Biarylurea derivatives According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells. ... 01/25/07 - 20070021415 - Pharmaceutical composition for the prevention or treatment of cerebral oedemas or of its pharmaceutically acceptable salts, in the preparation of a medicament for the prevention or treatment of cerebral oedemas. ... 01/18/07 - 20070015750 - Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents process for their production and their use as anti-inflammatory agents. ... 01/11/07 - 20070010514 - Non-steroidal progesterone receptor modulators a process for their preparation, the use of the progesterone receptor modulators for producing medicaments, and pharmaceutical compositions comprising these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynaecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhoea, and for ... 01/11/07 - 20070010513 - Carbon-linked substituted piperidines and derivatives thereof useful as histamine h3 antagonists R1 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma or cognition deficit disorders using said ... 01/04/07 - 20070004717 - Novel bicyclic compounds as modulators of androgen receptor function and method wherein R1, R2, R5, X and n are defined herein. ... 01/04/07 - 20070004716 - Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic ... 12/28/06 - 20060293317 - Use of non-steroidal progesterone receptor modulators for the therapy and prophylaxis of gynaecological disorders and of hormone-dependent tumours, and for use for female fertility control and for hormone replacement therapy. ... 12/21/06 - 20060287310 - [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other ... 12/21/06 - 20060287309 - [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other ... 12/07/06 - 20060276466 - Bicyclic heterocycles as hiv integrase inhibitors The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV. ... 12/07/06 - 20060276465 - 1,2-di(cyclic) substituted benzene compounds wherein R10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R30, R31 and R32 may be the same or different and each represents hydrogen etc., R40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X1 represents CH ... 12/07/06 - 20060276464 - Diarylsulfone sulfonamides and use thereof which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis. ... 11/30/06 - 20060270667 - Novel medicament combinations for the treatment of respiratory diseases The present invention relates to new medicament combinations which contain in addition to one or more, preferably one, betamimetic 1, at least one anticholinergic 2 and at least one PDEIV-inhibitor 3, processes for preparing them and their use as pharmaceutical compositions. ... 11/23/06 - 20060264430 - Pyrazole derivative X: —NR1—CR2R3—, —CR2R3—NR1—, —NR1—SO2—, —SO2—NR1— or —CR4═CR5—, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more ... 11/23/06 - 20060264429 - Benzoxazinone derivatives, preparation thereof and uses in the treatment of cns and other disorders wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including depression and anxiety, are also disclosed. ... 11/16/06 - 20060258652 - Beta-blockers having antioxidant and no-donor activity Multifunctional beta-antagonist compounds are provided, that combine β-adrenergic receptor blocking activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating disorders in which the treatment with β-antagonists is indicated, or which are ... 11/02/06 - 20060247236 - Purified form of tanaproget Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms. ... 11/02/06 - 20060247235 - Polymorph form ii of tanaproget Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating ... 11/02/06 - 20060247234 - Compositions containing micronized tanaproget prepared by wet granulation Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, ... 11/02/06 - 20060247233 - Thiazoles inhibitors of the alk-5 receptor The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signaling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and ... 10/26/06 - 20060241109 - Pgd2 receptor antagonists for the treatment of inflammatory diseases The values for the variables of Structural Formula (I) are provided herein. ... 10/19/06 - 20060235008 - Novel polymorphs of efavirenz The present invention relates to novel amorphous and crystalline forms of efavirenz, processes for their preparation and pharmaceutical compositions containing them. In accordance with the present invention efavirenz crude is dissolved in acetone at 25° C.-30° C., the solution is slowly added to water for 30 minutes at 0° C.-5° ... 10/12/06 - 20060229305 - Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents process for their production, and their use as anti-inflammatory agents. ... 10/12/06 - 20060229304 - (r)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted ... 10/05/06 - 20060223796 - Novel compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy ... 09/14/06 - 20060205719 - Novel compounds having an antibacterial activity These compounds are, amongst others, of interest as inhibitors of Topoisomerase IV (Topo IV) as well as of DNA gyrase. ... 09/07/06 - 20060199816 - Aryl sulfonyl piperidines as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome. ... 09/07/06 - 20060199815 - Nk1 antagonists wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. ... 09/07/06 - 20060199814 - Chemical intermediate Compounds of Formula I, wherein R2 represents C1-6 alkyl (optionally substituted by one or more substituents selected from —OH, halo, cyano, nitro and aryl) or aryl, wherein each aryl and aryloxy group, unless otherwise specified, is optionally substituted, and methods of preparation thereof are disclosed. ... 08/31/06 - 20060194801 - Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others. ... 08/31/06 - 20060194800 - Pteridine derivatives as nitric oxide synthase activators The present invention relates to the use of pteridine derivatives as nitric oxide synthase activators. In particular, the derivatives find use in the treatment of diseases associated with endothelial dysfunction such as cardiovascular diseases. ... 08/24/06 - 20060189607 - Long-acting betamimetics for the treatment of respiratory complaints wherein n, A, R1, R2 and R3 may have the meanings specified in the description and claims, processes for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints. ... 08/24/06 - 20060189606 - Methods for treating hepatitis c The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity. ... 08/24/06 - 20060189605 - New pharmaceutically-active compounds for the treatment of respiratory diseases wherein the groups R1, R2 and R3 may have the meanings specified in the claims and in the description, for preparing a pharmaceutical composition for the treatment of respiratory complaints, as well as new compounds of formula 1, processes for preparing them, and pharmaceutical formulations containing them. ... 08/10/06 - 20060178363 - Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity The present invention is directed to compounds of the formula (1) Wherein A, B, D, X, Y, n, R1, R3, R4, R5, R15, R16, R17, R18 and the dashed line are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as ... 08/03/06 - 20060173001 - Novel compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, orby chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for ... 07/27/06 - 20060166981 - Novel compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy ... 07/27/06 - 20060166980 - New oxabispidine compounds useful in the treatment of cardiac arrhythmias wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias. ... 07/27/06 - 20060166979 - New oxabispidine compounds useful in the treatment of cardiac arrhythmias wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias. ... 07/20/06 - 20060160796 - N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia: ... 07/20/06 - 20060160795 - Novel compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy ... 07/06/06 - 20060148795 - Novel compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy ... 06/29/06 - 20060142280 - Cyclothiocarbamate derivatives as progesterone receptor modulators wherein R1, R2, R3, R4, R5, and Q1 are defined herein. ... 06/15/06 - 20060128701 - Benzoxazinone-derived compounds, their preparation and use as medicaments The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals. ... 06/15/06 - 20060128700 - Morpoline-bridged indazole derivatives The present invention relates to novel morpholine-bridged indazole derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of disorders of the central nervous system. ... 06/08/06 - 20060122177 - Phenylpiperazines with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites wherein the symbols have the meanings given in the specification. ... 06/08/06 - 20060122176 - Azolidinone-vinyl fused-benzene derivatives The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1, R2 ... 05/18/06 - 20060106012 - Benzoxazine and quinoxaline derivatives and uses thereof or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein k, m, n, p, q, X, Y, Z, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I. ... 05/11/06 - 20060100204 - Anti-cytokine heterocyclic compounds which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds. ... 05/11/06 - 20060100203 - Fungicides based on nitrogen-containing heterocycles 1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. ... 05/11/06 - 20060100202 - Novel compounds wherein, R1, R2, P, p and n are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition containing such compounds and the use of such compounds in medicine. ... 04/27/06 - 20060089353 - Indole derivative compounds and drugs containing the compounds as the active ingredient (wherein the symbols in the formula are as mentioned in the specification) and a salt thereof Since the compounds represented by formula (I) binds to PGD2 receptors and shows antagonistic activity, they are believed to be useful for prevention and/or treatment of diseases such as allergic disease (such as allergic ... 04/20/06 - 20060084646 - Method of preparing alkylated salicylamides via a dicarboxylate intermediate The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well. ... 04/13/06 - 20060079520 - Sulfonamide peri-substituted bicyclics for occlusive artery disease A representative example is: ... 04/13/06 - 20060079519 - Anti-cytokine heterocyclic compounds which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds. ... 04/06/06 - 20060074081 - Progesterone receptor structure This invention relates to progesterone receptor/ligand complexes, and related methods and software systems. ... 04/06/06 - 20060074080 - Combination product comprising melagatran and an anti-arrhythmic oxabispidenes There is provided a combination product comprising: (1) melagatran or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 of WO 01/28992 or (2) a compound of Claim 34 of WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts thereof) ... 03/30/06 - 20060069094 - Compositions and methods for treating cognitive disorders Methods and pharmaceutical compositions relating to selective antagonists of the 5-HT6 receptor and 5-HT2A receptor useful for the treatment of cognitive disorders are presented. ... 03/30/06 - 20060069093 - Substituted 2h-1,3-benzoxazin-4(3h)-ones Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient. ... 03/30/06 - 20060069092 - Pharmaceutical compositions for the treatment of diseases related to neurotrophines The present invention refers to pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II) and (III) acting as agonists of human neurotrophines. Therefore, such compounds of formula (I), (II) and (III) are useful for treatment of diseases in which the ... 03/23/06 - 20060063762 - Indole indazole and benzazole derivative Q is, together with W, a group of the formula: —C(W)═C(R3A)—N(R3)—, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is ... 03/16/06 - 20060058292 - 2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized ... 03/02/06 - 20060046986 - Cytokine inhibitors which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds. ... 02/23/06 - 20060040933 - Nonsteroidal antiinflammatory agents are useful in the treatment of inflammation. ... 02/23/06 - 20060040932 - Stable crystalline form of bifeprunox mesylate (7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3h)-benzoxazolone monomethanesulfonate) The invention relates to a stable polymorphic form of the compound 7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate (INNM bifeprunox mesylate), a method for the preparation of said polymorphic form and its use in pharmaceutical products, especially in pharmaceutical products for the treatment of psychotic disorders and Parkinson's disease. ... 02/23/06 - 20060040931 - Benzomorpholine derivatives or pharmaceutically acceptable salts thereof and platelet aggregation inhibitors comprising the same. The compounds of the present invention have a strong inhibitory effect of platelet aggregation, so that they are effective for treating and preventing diseases in which thrombus is involved. ... 02/16/06 - 20060035891 - Cycloalkyl substituted pyrimidinediamine compounds and their uses The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers. ... 02/09/06 - 20060030561 - Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, ... 02/02/06 - 20060025410 - 2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized ... 12/22/05 - 20050282805 - Five-membered heterocycles useful as serine protease inhibitors or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation ... 12/08/05 - 20050272726 - Novel medicaments for the treatment of respiratory diseases wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of respiratory complaints. ... 12/01/05 - 20050267106 - New enentiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments wherein the groups R1, R2, R3, R4 and X− may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints. ... 12/01/05 - 20050267105 - Bicyclic heterocycles as hiv integrase inhibitors The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV. ... 11/24/05 - 20050261287 - Lactam-containing compounds and derivatives thereof as factor xa inhibitors or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa. ... 11/24/05 - 20050261286 - Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints. ... 11/17/05 - 20050256115 - Aerosol formulation for the inhalation of beta-agonists wherein the groups R1, R2, R3 and X− may have the meanings given in the claims and specification, for inhalation. ... 11/17/05 - 20050256114 - Novel long acting bronchodilators for the treatment of respiratory diseases wherein n, A, B, D, L, R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints. ... 11/17/05 - 20050256113 - Anti-cytokine heterocyclic compounds The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds. ... 11/10/05 - 20050250772 - Methods for inducing anti-anxiety and calming effects in animals and humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, or their precursor compounds, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to calm and/or reduce anxiety and related behaviors and ... 11/10/05 - 20050250771 - Substituted indoles and their use as integrin antagonists where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, , R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein. ... 11/03/05 - 20050245512 - Method and composition for rejuvinating cells, tissues organs, hair and nails In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce ... 10/27/05 - 20050239779 - Cyanopyrrole-containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, ... 10/27/05 - 20050239778 - Novel medicament combinations for the treatment of respiratory diseases wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, at least one other active substance 2, processes for preparing them and their use as pharmaceutical compositions. ... 10/20/05 - 20050234055 - Pyrazole derivative X: —NR1—CR2R3—, —CR2R3—NR1—, —NR1—SO2—, —SO2—NR1— or —CR4═CR5—, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more ... 10/13/05 - 20050227975 - New long acting beta-2-agonists and their use as medicaments wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints. ... 10/06/05 - 20050222145 - Cathepsin s inhibitors This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such ... 10/06/05 - 20050222144 - Medicaments for the treatment of chronic obstructive pulmonary disease R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD). ... 10/06/05 - 20050222143 - Helix mimetics and composition and methods related thereto including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, R1 and R2 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) ... 10/06/05 - 20050222142 - Phenylaminopropanol derivatives and methods of their use or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly ... 09/29/05 - 20050215547 - Optically active pyridine derivative and a medicament containing the same An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]α-azin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity. ... 09/22/05 - 20050209228 - 8-{4-[3-(5-fluoro-1h-indol-3-yl)-propyl]-piperazin-1-yl}-2-methyl-4h-benzo[1,4]oxazin-3-one mesylate with high affinity for the dopamine d2 receptor and the serotonin reuptake site The invention relates to the novel mesylate of a phenylpiperazine derivative of the formula (I). This salt has a favourable properties as compared with the free base of this compound. ... 09/22/05 - 20050209227 - Novel long acting betamimetics for the treatment of respiratory diseases wherein the groups R, R1, R2, R3 and A may have the meanings given in the claims and specification, processes for preparing them and their use as medicaments, particularly for the treatment of inflammatory and obstructive respiratory complaints. ... 09/22/05 - 20050209226 - Tetrahydroquinoline analogues as muscarinic agonists The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment ... 09/22/05 - 20050209225 - Substituted indoles and their use as integrin antagonists where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein. ... 09/22/05 - 20050209224 - Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic ... 08/11/05 - 20050176703 - Heterocyclic antiviral compounds This invention relates to piperidine derivatives of formulae Ia and Ib with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. More particularly, the present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one and 1-oxa-3,9-diaza-spiro[5.5]undecan-2-one compounds and related derivatives, ... 08/04/05 - 20050171100 - Process for the production of oxabispidines There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula ... 07/28/05 - 20050165011 - Benzoxazine and benzoxazinone substituted triazoles This invention relates to benzoxazine and benzoxazinone substituted triazoles which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β, type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the ... 07/14/05 - 20050153960 - Substituted arylamine derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention ... 07/07/05 - 20050148583 - Phenoxyalkylamine derivatives useful as opioid delta receptor ligands “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group ... 06/16/05 - 20050130962 - Benzoxazine derivatives and uses thereof a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I. ... 06/16/05 - 20050130961 - Muscarinic m1 receptor agonists for pain management Disclosed herein are compounds and methods for treating chronic neuropathic pain. It has been discovered that compounds that selectively interact with a muscarinic receptor subtype are effective in treating neuropathic pain. Specifically, compounds that selectively interact with the M1 muscarinic receptor subtype may be used. ... 06/09/05 - 20050124613 - Benzoxazine derivatives and uses thereof or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y and m are as defined herein. Also provided are compositions comprising, methods for using, and methods for preparing compound of formula (I). ... 06/02/05 - 20050119259 - Combination product comprising an anti-coagulant and anti-arrhythmic oxabispidenes There is provided a combination product comprising: (1) an anti-coagulant; and (1) a compound as defined in claim 1 of WO 01/28992 or (2) a compound of claim 34 of WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts thereof) for use in treating ... ### FreshPatents.com Support |