REGISTER now for FREE 
|
FREE patent keyword monitoring and additional FREE benefits. REGISTER now for FREE
|
|
|
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai > Hetero Ring Is Six-membered And Includes At Least Nitrogen And Sulfur As Ring Members > 1,4-thiazines 1,4-thiazines1,4-thiazines patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/25/07 - 20070021414 - 1-'2-(4-hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists This invention provides a compound of the formula (I), wherein R1 and R2 independently represents a hydrogen atom or the like; R3 represents an aryl group having from 6 to 10 ring carbon or the like; said aryl groups having from 6 to 10 ring carbon atoms and said heteroaryl ... 01/04/07 - 20070004712 - Salts of novel heterocyclic compounds having antibacterial activity The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions. ... 01/04/07 - 20070004711 - Thiazole compounds and methods of use wherein the variables Ar1, R2, R3, R4, r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly ... 12/28/06 - 20060293315 - Intermediates of novel heterocyclic compounds having antibacterial activity and process for their preparation The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions. ... 12/28/06 - 20060293314 - 4- piridinylmethylsulphonamide derivatives as fungicidal plant protein agents X is phenyl, naphthyl or a five- or six-membered saturated, or partially unsaturated or aromatic heterocycle which is attached via a carbon atom and contains one to four heteroatoms from the group consisting of O, N and S, where X may be substituted according to the description; Processes for preparing ... 12/21/06 - 20060287304 - Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient (wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, ... 12/21/06 - 20060287303 - Modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ... 12/21/06 - 20060287302 - Mitotic kinesin inhibitors The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. ... 12/14/06 - 20060281740 - Biphenyl compounds useful as muscarinic receptor antagonists wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of ... 12/14/06 - 20060281739 - Compositions and methods for treatment of eye disorders The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a ... 11/30/06 - 20060270665 - Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity The invention relates to a combination which comprises a first active ingredient which is a vasculostatic compound and a second active ingredient which decreases the activity of the epidermal growth factor (EGF), in particular, for the delay of progression or treatment of a disease associated with deregulated angiogenesis, especially a ... 11/23/06 - 20060264426 - Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. ... 11/23/06 - 20060264425 - Novel anthranilamide pyridinureas as vascular endothelial growth factor (vegf) receptor kinase inhibitors The invention relates to novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are triggered by persistent angiogenesis. ... 11/23/06 - 20060264424 - Arylsulfonamidobenzylic compounds Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment or prevention of lipid disorders, metabolic disorders and cell-proliferative diseases. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in cholesterol metabolism. The subject compounds are particularly useful in the treatment ... 11/02/06 - 20060247232 - Heterocyclic compound and antitumor agent containing the same as effective ingredient wherein X represents nitrogen atom or CH; R1 represents CHnF3-n (wherein n is 1 or 2), hydroxy C1-C6 alkyl, NHR6 [wherein R6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy)]; R2 represents morpholino (which may be substituted with one to four C1-C6 alkyl), ... 10/26/06 - 20060241105 - Pesticidal 1-ayl-3-amidoxime-pyrazole derivatives or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof, processes for their preparation, and methods for their use for the control of arthropods (including insects and arachnids) and helminths (including nematodes). ... // - 1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib): - ... 09/28/06 - 20060217373 - Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same a process for their preparation and their use as medicaments are described. ... 09/28/06 - 20060217372 - Diaryl ethers as opioid receptor antagonist A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related ... 09/21/06 - 20060211689 - Aminoquinoline derivatives and their use as adenosine a3 ligands The present invention relates to an adenosine A3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop, and optically active isomer) thereof, to a pharmaceutical composition containing the ligand, to the use of the ligand, to its preparation, ... 08/31/06 - 20060194798 - Bicyclic-substituted amines as histamine-3 receptor ligands are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I). ... 08/03/06 - 20060172999 - Tetrahydropyran compounds as tachykinin antagonists The present invention relates to the compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis ... 07/20/06 - 20060160794 - Tachykinin receptor antagonists The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins. ... 07/13/06 - 20060154923 - N-phenyl-3-cyclopropylpyrazole-4-carbonitriles as ectoparasiticidal agents R13 is H or a C1-C6alkyl, aryl or heteroaryl group each optionally substituted; or a stereoisomer or tautomer thereof. ... 07/13/06 - 20060154922 - Muscarinic agonists The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor. ... 05/18/06 - 20060106011 - 2-(bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation Compounds disclosed herein are bradykinin B1 antagonist compounds useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... 05/11/06 - 20060100201 - Inhibitors of c-fms kinase wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast ... 04/20/06 - 20060084644 - Novel pyridine compounds, process for their preparation and compositions containing them The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan. ... 03/23/06 - 20060063760 - Hydroxamic acids useful in the treatment of hyper-proliferative disorders This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders. ... 03/16/06 - 20060058289 - Mercaptoimidazoles as ccr2 receptor antagonists The present invention relates to a compound of formula (I) having CCR2 receptor antagonistic properties, particularly anti-infflammatory properties. ... 03/09/06 - 20060052374 - Amino-tetrazole analogues and methods of use is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed. ... 03/09/06 - 20060052373 - Combination of dopamine agonists and aralkyl and aralkylidene heterocyclic lactams and imides as defined in the specification, and optionally (iii) a pharmaceutically acceptable carrier, and to their medicinal use. These compositions are useful as psychotherapeutic agents. ... 03/02/06 - 20060046984 - Novel gamma-lactams as beta-secretase inhibitors or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure ... 02/09/06 - 20060030558 - Novel compounds as opioid receptor modulators This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders. ... 01/19/06 - 20060014737 - Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein. ... 01/12/06 - 20060009449 - Naphthaline derivatives as h3 inverse agonists and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors. ... 01/12/06 - 20060009448 - Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]thiomorpholin-3-one Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]-thiomorpholin-3-one, and use of same. ... 12/29/05 - 20050288281 - Hetero isonipecotic modulators of vanilloid vr1 receptor This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals. ... 12/22/05 - 20050282803 - Cis-imidazolines and the pharmaceutically acceptable salts and esters thereof, a process for their manufacture, medicaments containing them as well as the use of these compounds as pharmaceutically active agents. The compounds show antiproliferative activity and may be especially useful for the treatment of cancer. ... 12/22/05 - 20050282802 - Disalt inhibitors of il-12 production This invention relates to disalt nitrogen-heteroaryl inhibitors of IL-12 production, and related methods and pharmaceutical compositions. ... 12/08/05 - 20050272725 - Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol where * indicates a chiral center, R1 and R2 each independently represent H, C1-C6alkyl, —CN or —CCH, and R3 and R4 each independently represent H or C1-C6alkyl. ... 12/01/05 - 20050267104 - Acyloxymethylcarbamate prodrugs of oxazolidinones The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria. ... 11/24/05 - 20050261285 - Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R15 and R16 represent a variety of substituents; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or ... 11/17/05 - 20050256112 - Combination of atypical antipsychotics and 5ht-1b receptor antagonists (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally ... 11/10/05 - 20050250769 - Heterocyclic cannabinoid receptor antagonists and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors. ... 11/10/05 - 20050250768 - Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal. ... 11/03/05 - 20050245511 - Novel compounds that inhibit tryptase activity or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention of diseases that are mediated by tryptase activity. ... 10/27/05 - 20050239776 - Tachykinin receptor antagonists The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins. ... 10/20/05 - 20050234052 - Treatment for ocular infections The invention provides a method for treating ocular infections such as endophthalmitis. ... 10/20/05 - 20050234051 - 5-substituted 2-aryl-4 pyrimidinones Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are ... 10/20/05 - 20050234050 - Ph sensitive prodrugs of 2,6-diisopropylphenol The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of ... 10/13/05 - 20050227974 - Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers or a pharmaceutically-acceptable salt or solvate thereof, wherein n, X, R1, R2 and R3 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative ... 10/13/05 - 20050227973 - Human adam-10 inhibitors The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination ... 10/13/05 - 20050227972 - Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same a process for their preparation and their use as medicaments are described. ... 10/06/05 - 20050222140 - Phenylalanine derivatives as depeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed ... 09/22/05 - 20050209223 - Novel antibacterial compounds: process for their preparation and pharmaceutical compositions containing them their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ... 09/22/05 - 20050209222 - Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders. ... 09/22/05 - 20050209221 - Substituted heterocyclic compounds and methods of use The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion ... 09/15/05 - 20050203086 - Methods of treatment using an ep2 selective receptor agonist The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, ... 09/08/05 - 20050197334 - Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents. ... 09/01/05 - 20050192275 - Novel antimycobacterial compounds Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method ... 08/18/05 - 20050182049 - Combination of gamma-aminobutyric acid modulators and 5-ht1b receptor antagonists (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier. ... 08/18/05 - 20050182048 - 5-substituted-alkylaminopyrazole derivatives as pesticides The invention relates to the use for the control of parasites in animals, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for ... 08/11/05 - 20050176701 - Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain ... 08/04/05 - 20050171097 - 3-arylphenyl sulfide derivative and insecticide and miticide (wherein R is a C2-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group or the like, B0 to B2 and B3 are hydrogen atoms, halogen atoms, cyano groups, C1-C4 haloalkyl groups or the like, n is 0, 1 or 2, and Ar is a phenyl ring, a pyridine ... // - 3-Arylphenyl sulfide derivatives represented by general formula (I): - ... 08/04/05 - 20050171096 - Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), aggrecanase, or a combination thereof. ... 08/04/05 - 20050171095 - Combination of crf antagonists and 5-ht1b receptor antagonists (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally ... 07/21/05 - 20050159413 - Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders. ... 07/21/05 - 20050159412 - Bacterial enzyme inhibitors Compounds of formula (I) are antibacterial agents: wherein: Z is —N(OH)CH(═O) or —C(═O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula —N(OH)CH(═O), a hydroxy, halo or amino group; R2, R3 and R4 independently represents hydrogen or a group R10-(D)n-(ALK)m- wherein R10, D, n, ... 07/14/05 - 20050153959 - Heterocyclic anti-migraine agents as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as ... 07/14/05 - 20050153958 - Substituted aryl ketones A1, A2, A3, R1, R2, R3, R4, R5, R6, R7, X, Y, and m are as defined in the disclosure, to their use as pesticides, in particular herbicides, and to processes and intermediates for their preparation. ... 06/30/05 - 20050143376 - Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones or a pharmaceutically acceptable salt thereof wherein A, X, Y, Z, R2, R3, R4, R5, and R6 are as defined herein. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens. ... 06/30/05 - 20050143375 - Imidazole derivatives wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment of genitourinary diseases. ... 06/16/05 - 20050130959 - Inhibitors of cathepsin s The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively ... 06/16/05 - 20050130958 - Substituted 6−membered n−heterocyclic compounds and their uses as neurological regulator This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for ... 06/09/05 - 20050124610 - Amino substituted pyridinyl methanone compounds useful in treating kinase disorders The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the ... 06/02/05 - 20050119257 - Cyclic sulfone containing retroviral protease inhibitors The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease. ... 06/02/05 - 20050119256 - Aromatic amino acid derivates and medicinal compositions R3 is {circle over (1)} a hydrogen atom, {circle over (2)} an aroylamino group, {circle over (3)} a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. {circle over (4)} a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, {circle over (5)} an unsaturated mono-cyclic heterocyclic ... // - 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: - ... 06/02/05 - 20050119255 - Phenylpyrimidine amines as ige inhibitors An amine, which is substituted by phenyl-substituted pyrimidin; and phenyl; and a third substituent and its use as an immunoglobulin E (IgE) inhibitor. ... ### FreshPatents.com Support |