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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Phosphorus Containing Other Than Solely As Part Of An Inorganic Ion In An Addition Salt Doai > Nitrogen Containing Hetero Ring > Polycylo Ring System Having A Ring Nitrogen In The System Polycylo Ring System Having A Ring Nitrogen In The SystemPolycylo Ring System Having A Ring Nitrogen In The System patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.01/11/07 - 20070010491 - Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective ... 12/28/06 - 20060293282 - Substituted aminoalkanephosphonic acids The present invention relates the use of substituted aminoalkanephosphonic acids in treating neuropathic pain, affective and attention disorders, schizophrenia, tinnitus, myopia and other ocular disorders. ... 12/21/06 - 20060287280 - Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed. ... 12/07/06 - 20060276436 - Farnesyl dibenzodiazepinone formulation The invention relates to pharmaceutical formulations comprising a farnesyl dibenzodiazepinone compound, or an analog, or a pharmaceutically acceptable salt or prodrug thereof, and a pharmaceutically acceptable surfactant and having improved chemical and biological properties. Such a formulation is a ready-to-use solution suitable for parenteral or non-parenteral administration or a bulk ... 11/23/06 - 20060264405 - Phosphorus-containing macrocycles This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties. ... 11/23/06 - 20060264404 - Therapeutic phosphonate compounds The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents. ... 11/23/06 - 20060264403 - Aminopropanol derivatives wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them. ... 11/16/06 - 20060258625 - Process for the preparation of biphosphonic derivatives The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 ... 11/02/06 - 20060247211 - Cytotoxic indeno and isoindoloisoquinolones The synthesis and biological activity of benzoisoindoloisoquinolone compounds are described. The synthesis and biological activity of C-11-substituted indenoisoquinolones are also described. Indenoisoquinolones substituted at C-11 are prepared by McMurry reactions of 11-ketoindenoisoquinolones with aldehydes. ... 11/02/06 - 20060247210 - Pyrazolylbenzothiazole derivatives and their use as therapeutic agents Pharmaceutical pyrazolybenzothiazole compositions of formula (1) are provided. The compositions may be pharmaceutically acceptable salts. R1, R2 and R3 at each occurrence are independently selected from amino, aminosulfinyl, aminosulfonyl, aryl, azido, halogen, heteroalkyl, heteroaryl, hydrazinyl, hydrocarbyl, hydrogen, hydroxyl, nitro, nitroso, phosphate, phosphinate, phosphonate, phosphonium, phosphorothioate, phosphoryl, sulfamoyl, sulfate, sulfinic acid, ... 10/05/06 - 20060223783 - 3,4-disubstituted coumarin and quinolone compounds The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative. ... 09/21/06 - 20060211656 - Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators wherein X, a, b, R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them. ... 09/14/06 - 20060205692 - 1,1-and 1,2-bisphosphonates as apoliprotein e modulators The present invention relates to methods of use 1,1- and 1,2-bisphosphonate compounds to modulate apolipoprotein E levels and use of such compounds in therapy, including cardiovascular and neurological disease states. ... 08/31/06 - 20060194766 - Combinations comprising anti-epileptic drugs for the treatment of neurological disorders This invention relates to combinations comprising two anti-epileptics, pharmaceutical compositions comprising such combinations, and the use of such combinations for the preparation of a medicament for the treatment of neurological disorders, esp. epilepsy. ... 07/13/06 - 20060154897 - Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective ... 06/29/06 - 20060142248 - Xanthurenic acid derivative pharmaceutical compositions and methods related thereto R4 and R8 are independently H, (═O); hydroxy; or optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or —P(O)(ORa)(ORb) or —NRaRb, where Ra and Rb are independently H, or optionally substituted aliphatic, cycloalkyl or heterocycloalkyl, aryl or heteroaryl; or a prodrug or pharmaceutically acceptable salt thereof; and a pharmaceutically ... 06/22/06 - 20060135481 - Narcistatin prodrugs The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including ... 06/22/06 - 20060135480 - Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula (I), useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for ... 06/15/06 - 20060128668 - Pancratistatin cyclic phosphate prodrugs an phenpanstatin cyclic phosphate prodrugs Selective phosphorylation of phenpanstatin (3a) with tetrabutylammonium dihydrogen phosphate and dicyclohexyl-carbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient route to a new series (3b-3d) of promising 3,4-O-cyclic phosphate prodrugs designated phenpanstatin phosphates. Application of analogous reaction conditions to pancratistatin (1a) led to a ... 06/15/06 - 20060128667 - Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators The present invention relates to the novel hydroxyphosphonates and phosphonophosphates and the methods of their use to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... 06/01/06 - 20060116357 - Phosphonooxy quinazoline derivatives and their pharmaceutical use Quinazoline derivatives of formula (I) wherein A is 5-membered heteroaryl containing a nitrogen atom and one or two further nitrogen atoms; compositions containing them, processes for their preparation and their use in therapy. ... 04/06/06 - 20060074054 - Phospho-indoles as hiv inhibitors 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds. ... 03/30/06 - 20060069066 - Glycogen synthase kinase-3 inhibitors Novel compounds designed to allow interactions with binding sites of GSK-3 and hence are capable of inhibiting GSK-3 activity, via inhibition of substrate binding are disclosed. Further disclosed are pharmaceutical compositions including same and methods of using same in the treatment of GSK-3 mediated conditions. ... 02/23/06 - 20060040900 - R(-)-11-hydroxyaporphine derivatives and uses thereof The invention features derivatives of R(—)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith. ... 02/09/06 - 20060030544 - Protein kinase and phosphatase inhibitors and methods for designing them The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may ... 01/26/06 - 20060019928 - Tricyclic-heteroaryl compounds useful as kinase inhibitors wherein, Q is optionally substituted aryl or heteroaryl, R1 is hydrogen or C1-4alkyl, and R2, R3, R4 and R5 are hydrogen or optional substituents as defined in the specification. ... 01/19/06 - 20060014725 - Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (pai-1) wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, ... 01/05/06 - 20060003967 - Method for preparing pyrrolotriazine compounds A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V, ... 12/22/05 - 20050282781 - Compositions of stable bioactive metabolites of docosahexaenoic (dha) and eicosapentaenoic (epa) acids An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce ... 12/01/05 - 20050267073 - Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or ... 12/01/05 - 20050267072 - Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction The present invention relates to the novel medicinal use of dually acting compounds capable of inhibiting neutral endopeptidase (=NEP) and human soluble endopeptidase (=hSEP) in the prophylaxis and/or treatment of sexual dysfunction in mammals and humans. ... 11/24/05 - 20050261246 - Methods for treating inflammatory and autoimmune diseases The present invention provides methods for treating inflammatory conditions, rheumatoid diseases, autoimmune conditions, and conditions associated with bone loss, comprising administering to a subject with an inflammatory condition an amount effective to treat the condition of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′ phosphate and pancratastatin-3′,4′ ... 11/17/05 - 20050256087 - Phosphonic acid diester compounds and an ACAT-1 inhibitor containing the compound as an active ingredient. ... 11/10/05 - 20050250742 - Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting nima (pin1) Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell ... 10/20/05 - 20050234022 - Use of 2-alkoxyphenyl-substituted imidazotriazinones The present invention relates to the use of known 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position and cGMP PDE-inhibitory properties for the production of medicaments for the treatment of cardiac insufficiency, psoriasis, female infertility, cancer, diabetes, ophthalmic disorders such as glaucoma, disorders of gastric motility, cystic fibrosis, ... 09/29/05 - 20050215525 - Anti-infective phosphonate analogs The invention is related to phosphorus substituted anti-infective compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. ... 09/22/05 - 20050209195 - Indolinone derivatives Novel derivatives of compound (E)-1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-2H-indol-2-one and the use thereof for the preparation of medicaments for the treatment of tumors in which the tyrosine kinase activity proteins Met, PDGF-R, FGF-R1, FGF-R3, Kit and the oncoproteins of the Ret family are involved. ... 09/08/05 - 20050197320 - Non nucleoside reverse transcriptase inhibitors Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes. ... 09/01/05 - 20050192253 - Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... 07/21/05 - 20050159391 - Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, ... 07/14/05 - 20050153936 - Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neuro-degenerative disorders wherein the symbols have the meanings as given above in the description. ... 07/14/05 - 20050153935 - Compound and method for treating androgen-independent prostate cancer The present invention provides compositions and methods for treating prostate cancer. The composition comprises a morpholino antisense compound having uncharged phosphorus-containing backbone linkages and a base sequence that is complementary to a target region containing at least 12 contiguous bases in a preprocessed or processed human androgen receptor transcript. The ... 06/23/05 - 20050137171 - Novel organophosphorus derivatives of indazoles and use thereof as medicinal products The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers. ... 06/23/05 - 20050137170 - Novel phosphorous containing steroid mimics phosphorous atom in the above structures 3-7 is indicated at 13, 14, and 17 positions, it is to be noted that the phosphorous can be substituted at any one of the seventeen positions in non-aromatic or eleven positions in aromatic steroids. The phosphorous atom may be trivalent or tetravalent, and ... 06/02/05 - 20050119228 - Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... ### FreshPatents.com Support |