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Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) > Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai > Cyclopeptides > Bicyclic

Bicyclic

Bicyclic patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

02/08/07 - 20070032412 - Use of kahalalide compounds for the manufacture of a medicament for the treatment of psoriasis
Kahalalide compounds, in particular kahalalide F, are of use in a method to treat a mammal suffering from skin disease with avoiding toxicity and leading to clinical improvement. ...

12/14/06 - 20060281671 - Organic compounds
Analogues of the amino acid sequence KAPREKY and their use in screening for compounds which interacts with FcεRIα. ...

12/07/06 - 20060276380 - Antimicrobial peptide, compositions, and uses therefor
The invention refers to small peptides with low hemolytic activity, presenting similar antiparasitic, antifungal and antibacterial activities. More specifically, it refers to a peptide called gomesin, with 18 amino acid residues, configured as a hairpin structure consisting of two anti-parallel beta-folded sheets joined by a beta turn, containing four invariable ...

10/05/06 - 20060223747 - Therapeutic agent for soft tissue sarcoma
A therapeutic agent for soft tissue sarcoma (particularly synovial sarcoma) contains a histone deacetylase inhibitor (particularly compound of formula I) as an active ingredient ...

09/28/06 - 20060217295 - Neuroprotective macrocyclic compounds and methods for their use
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions. ...

08/10/06 - 20060178298 - Antitumoral treatments
Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies. ...

08/03/06 - 20060172926 - Aplidine for multiple myeloma treatment
Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma. ...

06/22/06 - 20060135413 - Depsipeptide for therapy of kidney cancer
The present invention provides a therapeutic agent of kidney cancer, which comprises FK228 of the formula (I) or a salt thereof. FK228 or a salt thereof, which is an active ingredient in the present invention, shows a superior antitumor activity in vivo against kidney cancer. ...

04/20/06 - 20060084596 - Growth factor binding molecules
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In ...

02/02/06 - 20060025333 - Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac hypertrophy. Surprisingly, the present invention demonstrates that HDAC inhibitors inhibit cardiac hypertrophy by ...

12/08/05 - 20050272647 - Arthrodial cartilage extracellular matrix degradation inhibitor
An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, ...

11/24/05 - 20050261174 - Insecticidal activity of a cyclic peptide
A cyclic peptide isolated from an extract of the bark of a Madagascan plant, having a structure of formula (I), has insecticidal activity. ...

10/06/05 - 20050222015 - Dehydrodidemnin b
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives. ...

09/22/05 - 20050209135 - Process for preparing macrocyclic compounds
and the other variables are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection. ...

09/22/05 - 20050209134 - Novel depsipeptide compound
The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an ...

08/25/05 - 20050187149 - Antitumor agent
An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the ...

08/25/05 - 20050187148 - Antitumor agent
An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the ...

08/04/05 - 20050171011 - Depsipeptide and congeners thereof for use as immunosuppressants
wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease ...

07/14/05 - 20050153877 - Macrocyclic hepatitis c serine protease inhibitors
wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. ...

06/16/05 - 20050130883 - Serine protease inhibitors
The present disclosure concerns peptides and peptidomimetics having inhibitory activity against serine proteases. The disclosed peptides and peptidomimetics are particularly useful as selective inhibitors of matriptase and MTSP1. Pharmaceutical compositions comprising serine protease inhibitors and methods for administering the compositions also are disclosed. ...

06/02/05 - 20050119169 - Spatially-defined macrocycles incorporating peptide bond surrogates
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian ...



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