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Chemistry: Analytical And Immunological Testing > Involving An Insoluble Carrier For Immobilizing Immunochemicals Involving An Insoluble Carrier For Immobilizing ImmunochemicalsInvolving An Insoluble Carrier For Immobilizing Immunochemicals patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087452 - Luminescent lanthanide complexes Here, R1, R2, and R3 are substituents of the tetraazacyclododecane ring system, that is further substituted at the 10-position by a sensitizer Z that is typically a polyheterocyclic ring system. The organic chelator may be capable of forming a luminescent complex with a lanthanide ion, and is optionally further substituted ... 04/12/07 - 20070082410 - Stabilization of cardiac troponin The present invention relates to a troponin protein or complex of two troponin proteins stabilized in a matrix containing at least one anionic surfactant. The stabilized troponin or complex of troponin proteins is used as a control or calibration standard in assays for the determination of blood levels of troponin ... 03/29/07 - 20070072308 - Methods of forming monolayers of phage-derived products and uses thereof Methods and compositions for identifying and characterizing the affinity of one or more ligands of a peptide are provided. In particular, a “stripped phage ligand sensor device” (SPLSD) is provided comprising a sensor coupled to a binding element of interest. Binding elements of the invention comprise phage which in most ... 03/29/07 - 20070072307 - Methods of purifying fc region containing proteins The present application provides methods of purifying polypeptides having a Fc region, for example, antibodies or antibody fusions, by adsorbing the polypeptides to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and ... 03/22/07 - 20070065953 - Methods for reducing the range in concentrations of analyte species in a sample The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures. ... 03/15/07 - 20070059845 - Reagents for the detection of protein phosphorylation in t-cell receptor signaling pathways The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such ... 03/15/07 - 20070059844 - Non-metameric color matching system and method A pigment library and a method for preparing it are provided, which includes identifying a plurality of thermoplastic polymers and then selecting pigments useful in the plurality of thermoplastic polymers. The pigments are heat stable at the melt temperature of each of the plurality of thermoplastic polymers and are not ... 03/15/07 - 20070059843 - Method of high-speed detection for biological analyte This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and ... 03/08/07 - 20070054416 - High density sample holder for analysis of biological samples A sample holder comprises a substrate microfabricated to define a multiplicity of microscopic islands defining sample support surfaces. At least one sump separates adjacent island surfaces and inhibits transport of samples between adjacent island surfaces. ... 03/08/07 - 20070054415 - Method and apparatus for assay in utilizing attenuated total reflection A surface plasmon resonance (SPR) assay apparatus is provided, in which a flow channel, a sensing surface and an optical assay unit are used. The sensing surface is associated with the flow channel, and contacted by a sample in the flow channel. The optical assay unit applies illuminating light to ... 02/22/07 - 20070042506 - Apparatus for carrying out an analysis process, in particular for identification of biochemical molecules, and analysis process which can be carried out using this apparatus An apparatus is disclosed for carrying out an analysis process, in which probe molecules which are immobilized on a substrate within an analysis area are brought into contact with an analyte solution, which contains target molecules as reaction partners, and reaction events are detected between target molecules and probe molecules ... 02/22/07 - 20070042505 - Liquid crystal based analyte detection The present invention relates to the field of detection of analytes, and in particular to detection of analytes using a liquid crystal assay format. In the present invention, analytes binding in a detection region is identified by changes in liquid crystal orientation caused by analyte binding independent orientation caused by ... 02/08/07 - 20070031979 - Protein biopolymer markers predictive of type ii diabetes The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 02/01/07 - 20070026535 - Novel methodology of conjugating chelators to biomolecules A novel method of conjugating chelators to biomolecules such as proteins is provided. More particularly, the invention provides compositions and methods of using those compositions for the detection, purification and transport of divalent metal cation binding biomolecules. ... 01/11/07 - 20070010030 - Complement c3 precursor biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 01/11/07 - 20070010029 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/28/06 - 20060292703 - Biopolymer marker indicative of disease state having a molecular weight of 2753 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/28/06 - 20060292702 - Method for modeling an simulating a biological system, and model carrying out this method A method of modeling and simulating a biological system comprising one or more tangible biological functional entities modeled by at least: a morphological occurrence comprising at least a biochemical constituent that identifies the biological functional entity and at least a transformation representing the way in which that constituent behaves as ... 12/21/06 - 20060286682 - Surface treatment Described is a process for producing a biomolecular monolayer on a biosensor surface comprising the steps of: reacting a biosensor surface with a solution of heterobifunctional reagent having a first functional group and a second functional group, the first functional group being capable of forming a covalent bond to the ... 12/21/06 - 20060286681 - Proximal markers of arterial thrombosis and inflammation for risk stratification of coronary heart disease The present invention relates to a method for establishing a diagnosis if an individual has suffered from or a prognosis if an individual is at risk of suffering from a coronary heart event, which method comprises determining the concentration of sCD40L in a body fluid of the individual; determining the ... 12/21/06 - 20060286680 - Fiber-optic biosensor and biosensing methods A method for biosensing that includes passing, via convective flow, a sample believed to contain one or more target biomarkers through a microfluidic channel and over the surface of an optical waveguide that has been prepared to bind the one or more target biomarkers, and sensing for an emission output ... 12/07/06 - 20060275923 - Methods for reducing the range in concentrations of analyte species in a sample The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures. ... 11/30/06 - 20060270064 - Methods and apparatus for blood typing with optical bio-discs This invention relates to clinical diagnostic assays and related optical bio-discs and a disc-reading apparatus. The invention is directed to a methods for determining the blood cell type of an individual. ... 11/30/06 - 20060270063 - Compositions for use as a signal generation component and methods of using same wherein R is one or more substituents, each substituent comprising an electron donating group; n=2-10; x=1-2; and y=2-4. ... 11/30/06 - 20060270062 - Mass spectrometric immunoassay Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass ... 11/23/06 - 20060263904 - Analyte detection using an active assay Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer ... 11/16/06 - 20060258021 - Biocompatible linkers for surface plasmon resonance biosensors A method of coating an SPR biosensor specific for an analyte to reduce protein fouling, the method has the steps of providing an SPR biosensor, providing a solution of 11-mercaptoundecanol; incubating the SPR biosensor in the 11-mercaptoundecanol solution to form a self-assembling monolayer (SAM); incubating the SPR with SAM in ... 11/09/06 - 20060252159 - Photocrosslinked hydrogel blend surface coatings Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone ... 11/02/06 - 20060246603 - Generation of chemiluminescence by hydrogen The invention concerns a method for detecting an analyte in a sample using a luminescent metal complex as a labelling group and a device that is suitable therefor. ... 10/26/06 - 20060240571 - Biosensors and methods for detecting agents based upon time resolved luminescent resonance energy transfer Disclosed are biosensors useful in the detection of potentially harmful or undesirable agents, particularly chemicals and microorganisms in food and water. The biosensors operate under the principle of time-resolved luminescence resonance energy transfer. In a preferred embodiment, the biosensor comprises at antibodies that recognized different but proximal epitopes on a ... 10/26/06 - 20060240570 - Cobalamin assay The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates. ... 10/19/06 - 20060234392 - Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment The present invention provides methods and reagents for detecting anti-phospholipid-cofactor protein-antibodies. ... 10/19/06 - 20060234391 - Optical sensor based on resonant porous silicon structures A sensor includes at least one high refractive index layer; and at least one low refractive index layer coupled to the high refractive index layer. ... 10/19/06 - 20060234390 - Process for determining target function and identifying drug leads The present invention relates to methods for using chemical ligands to determine target function and identify drug leads. ... 10/05/06 - 20060223196 - Method and system for controllably releasing solutions A method and system for releasing active ingredients into the surrounding atmosphere is disclosed. In one embodiment, the dispersion rate of the active ingredient through the membrane is passively regulated by adjusting the porosity of the membrane. In another embodiment, materials with microfluidic channels of various diameters are interposed together ... 10/05/06 - 20060223195 - Stress based removal of nonspecific binding from surfaces A biological material sensing surface is exposed to a biological material that is selectively bound to a selected sensing portion of the sensing surface. The sensing surface is then subjected to shear stress oscillations to selectively remove nonspecifically bound material. The shear stress may be provided by an ultrasound resonator ... 09/21/06 - 20060211150 - Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211149 - Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211148 - Protein biopolymer markers indicative of age matched control The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211147 - Protein biopolymer markers indicative of age matched control The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211146 - Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211145 - Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211144 - Protein biopolymer markers indicative of age matched control The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211143 - Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211142 - Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211141 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211140 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211139 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211138 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211137 - Biosensor It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention ... 09/21/06 - 20060211136 - Method for gold deposition A method for depositing gold on a substrate is provided. By this aspect nucleation centers are bound, deposited or formed at one or more sites on the substrate, the substrate is then contacted with a treatment composition which comprises soluble gold-providing agent from which gold is deposited onto a nucleation ... 09/14/06 - 20060205091 - Protein biopolymer markers predictive of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/14/06 - 20060205090 - Water-soluble conjugates for electrochemical detection The present invention provides water-soluble conjugates and methods of using them in diagnostic and detection assays. Devices for performing detection and quantitation assays are also provided. In various embodiments the conjugates are useful in immunoassays and later flow assays. The invention provides methods of preparing the conjugates that result in ... 09/14/06 - 20060205089 - Mapping discontinuous antibody or aptamer epitopes for protein structure determination and other applications The present invention is directed to methods of mapping antibody or aptamer epitopes for use in a variety of utilities including the elucidation of the tertiary structure of proteins. A method of the invention, antibody imprinting, uses antibodies or aptamers against target proteins and random peptide probe libraries to map ... 09/07/06 - 20060199280 - Quantification of proteins The invention provides a method and kit for determining the quantity of certain proteins comprising post-translationally modified sulfhydryl groups. The invention also provides a method and kit for determining the quantity of a protein having no cysteines in its amino acid sequence. ... 09/07/06 - 20060199279 - Methods for identifying post-translationally modified polypeptides The invention provides methods of analyzing a sample. In general, the methods involve multi-dimensionally fractionating a sample to produce a set of sub-fractions, identifying a sub-fraction of interest by evaluating binding of a first portion of the sub-fractions to a binding agent; and analyzing the mass of analytes in a ... 08/31/06 - 20060194345 - Concentration measuring method, concentration measuring kit, and sensor chip for use in the method The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the ... 08/31/06 - 20060194344 - Plasmon resonant structure, controlling method thereof, and a metallic domain manufacturing method Metallic particle layers with metallic domains being arranged therein each at a predetermined space within a horizontal plane are laminated at an appropriate distance in the vertical direction in a dielectric layer. The distance ΔW between each of the metallic domains may be controlled by controlling the growth of metallic ... 08/31/06 - 20060194343 - Sensor chips A method for selectively orienting molecules on a surface of a solid support. The method includes the steps of: (a) attaching a linker molecule to the surface of the solid support, the linker molecule including a head group that is capable of binding to the solid support, and a tail ... 08/31/06 - 20060194342 - Agglutination based sample testing device A sample testing device (100) for testing for the presence of a component of interest in a liquid sample comprises: (a) at least one capillary pathway (120) which has an upstream end and a downstream end and which incorporates a reagent system capable of causing agglutination with said component to ... 08/31/06 - 20060194341 - Library of compounds labelled with radiosotope Library of compounds or their pharmaceutically acceptable salts, each compound being associated with information on its chemical identity and structure, wherein at least two of the compounds is labelled with radioisotope characterised in that the radioisotope is an AMS active radioisotope; A solid support having a compound or its pharmaceutically ... 08/31/06 - 20060194340 - Protein biopolymer markers predictive of type ii diabetes The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 08/31/06 - 20060194339 - Protein biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 08/31/06 - 20060194338 - Complement c3 precursor biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 08/31/06 - 20060194337 - Fibronectin precursor biopolymer markers indicative of alzheimer's disease The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 08/24/06 - 20060189001 - Ssx-2 peptides presented by hla class ii molecules The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized ... 08/17/06 - 20060183245 - Prevention and treatment of atherosclerosis by reducing carbamylation of ldl or the effects of carbamylated ldl The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of measuring the level of cLDL and/or autoantibody to cLDL in a sample obtained from this individual. The invention further discloses a method of reducing carbamylation in an individual with a ... 08/10/06 - 20060177944 - Ri-labeled compound synthesizing system An RI-labeled compound synthesizing system comprises an RI material synthesizing section that synthesizes a labeled precursor by using a radioisotope; a plurality of RI compound manufacturing sections into which the labeled precursor and a reagent are introduced and in which a radioisotope-labeled compound is manufactured; and a switching device that ... 08/10/06 - 20060177943 - Method of inhibiting nonspecific interaction between molecules on solid phase support The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the ... 08/03/06 - 20060172437 - Method for manufacturing a carrier for chemical or biochemical assays Method for manufacturing a preparation carrier, in particular suitable for use in chemical and biochemical research, wherein: on at least one surface of a carrier base, a layer of plastic is provided, wherein the plastic layer is treated thermally and/or chemically, such that the surface roughness of the side of ... 08/03/06 - 20060172436 - Diagnosis supporting system A diagnosis supporting system (10) includes a diagnosis data obtaining unit (20) that obtains diagnosis data in which a movement parameter reflecting a movement speed of each component in separating a sample collected from a test subject into plural components with a chip (12) and a character of each component ... 07/20/06 - 20060160246 - Graphitic nanotubes in luminescence assays Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional ... 07/20/06 - 20060160245 - Methods to view and analyze the results from diffraction-based diagnostics An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of different diffraction-based diagnostic methods and systems. The analyzer enhances the accuracy and/or usefulness of these devices in ... 07/13/06 - 20060154379 - Process for structuring a surface layer A process for structuring a surface layer of an object includes applying bio-components to the surface of the object that carry away surface material. The bio-components are contained in at least one of a nutrient and osmotic protective medium. The at least one of a nutrient and osmotic protective medium ... 07/06/06 - 20060148101 - Fluorescent ligands for gpcr arrays Microarrays employing a fluorescent ligand including a material having a binding affinity in the range of about 0.01 to about 25 nM, or about 0.1 to about 10 nM; a specificity to its cognate receptor in the range of about 50 to about 99%, or about 65 to about 99%; ... 07/06/06 - 20060148100 - Real time binding analysis of antigens on a biosensor surface The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors. ... 07/06/06 - 20060148099 - Sensor device for determining protein aggregation The present invention relates to a sensor device and method for determining the extent of aggregation of a protein such as beta amyloid in a fluid (e.g. a bodily fluid). ... 07/06/06 - 20060148098 - Method and kit for detecting antigens The invention relates to a method for the detection of an antigen, the antigen being in the presence of aluminium hydroxide, and kits comprising instructions and components suitable for carrying out said method. ... 06/15/06 - 20060128033 - Fluorogenic dyes Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule. ... 06/15/06 - 20060128032 - Biosensor It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The present invention provides a biosensor, which comprises a substrate coated with a hydrophobic polymer having an alkyl group substituted ... 06/15/06 - 20060128031 - Addressable recovery of bound analytes from an evanescent wave sensor The invention provides an evanescent wave sensor containing a cleavably bound capture agent. Upon exposure of the sensor to a suitable stimulus the capture agent and any analyte bound thereto are released from the sensor. The released analyte may be transferred into a mass spectrometer apparatus and investigated therein. ... 06/15/06 - 20060128030 - Bioassay substrate and bioassay device and method A bioassay substrate (1) takes a flat-plate shape in which the principal surface similar to that of optical disc such as CD, etc. is circular. At the center of the substrate (1), there is formed a center hole (2) into which a chucking mechanism for rotation and holding is inserted. ... 06/08/06 - 20060121627 - Diluent, methods of manufacture and use The use of diluent to reduce non-specific drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of ... 06/01/06 - 20060115907 - Immune complex-specific antibodies for increased sensitivity in immunoassay array tests The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bnx are bound on different discrete areas on a support where Bnx in each case contain the various antigens ... 06/01/06 - 20060115906 - Sensor surface comprising an improved signal-noise ratio The present invention concerns a sensor surface with an improved signal/noise ratio that is based on a blocking reagent covalently immobilized on the sensor surface, as well as apparatuses comprising such surfaces and methods for the use of same. ... 05/18/06 - 20060105472 - Reduction of non-specific binding in assays Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the ... 05/18/06 - 20060105471 - Coated metal surface on solid support useful in analyte detection by displacement A coated metal surface on a solid support, wherein the coating consists of a protein layer firmly attached to the metal surface, and said protein layer is coupled to linker molecules that are bound to low molecular weight antigens, wherein the linker molecules are coupled to the protein layer and ... 05/11/06 - 20060099720 - Methods for performing differential capture proteomics Disclosed herein are improved methods for identifying, isolating, and comparing proteins and other biomolecules differing between two biological samples using affinity chromatography and phage display techniques. ... 04/27/06 - 20060088945 - Electrochemical test device and related methods An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with ... 04/20/06 - 20060084186 - System and method for identifying proteins A method is disclosed for identifying one or more specific proteins in a heterogeneous test solution with a plurality of micro-cantilevers which have two or more conductive arms coupled to an end area having a higher resistance than the conductive arms. The method includes the operation of heating each end ... 04/06/06 - 20060073611 - Immunoassay The present invention relates to methods of assaying the levels of proteins or antibodies in a test sample. In particular, the present invention relates to a method of determining the relative abundance of a plurality of proteins in a test sample compared to a reference sample, the method comprising: (a) ... 04/06/06 - 20060073610 - Patterned composite membrane and stenciling method for the manufacture thereof A patterned composite membrane useful, for example, in proteomic and genomic biopolymer characterization is disclosed. The patterned composite membrane, in general, comprises a substantially planar support and porous material arranged thereon to define a plurality of discrete binding sites. Each binding site is configured such that it will preferentially bind ... 03/30/06 - 20060068505 - Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 03/30/06 - 20060068504 - Functional particle array and method of use thereof In a capillary bead array, a method for retaining stably in a capillary an agent, enzyme, and fluorescent labeling agent necessary for a chemical reaction performed therein by functional particles and eluting the agent or the like in the capillary is provided. Further, a method for adsorbing and separating various ... 03/30/06 - 20060068503 - Solid support membranes for ion channel arrays and sensors: application ro rapid screening of pharmacological compounds The present invention relates to synthetic membranes and provides a solid supported membrane comprising: a support; a chromium layer; a gold layer; an alkyl monolayer, a lipid monolayer; and an ion channel protein, wherein the alkyl monolayer and the lipid monolayer form a bilayer, and further wherein a functionally reconstituted ... 03/30/06 - 20060068502 - Sensor constructs and detection methods Sensor constructs for detecting the presence of an analyte in a sample comprise a molecular scaffold, a pair of labels which interact via Förster resonance energy transfer, and at least one molecular recognition domain. When the analyte is bound by the molecular recognition domain, the Förster resonance energy interaction between ... 03/23/06 - 20060063276 - Alteration of surface affinities The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be ... 03/16/06 - 20060057741 - Rapid classification of biological components A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to ... 03/16/06 - 20060057740 - Method for manufacturing tool for analysis The present invention relates to a method of manufacturing an analytical tool, where the method includes a reagent member forming process for preparing a reagent member containing a reagent to react with a specific component contained in sample liquid. The reagent member forming process includes a plurality of applying and ... 03/09/06 - 20060051879 - Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. ... 03/09/06 - 20060051878 - Nano-sized optical fluorescence labels and uses thereof A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a ... 03/09/06 - 20060051877 - Fibronectin biopolymer marker indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 03/02/06 - 20060046313 - Cellular analysis using raman surface scanning Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly ... 03/02/06 - 20060046312 - Biosensor using microdisk laser A compact sensor for detecting the presence of biological or chemical species includes a microdisk laser and a wavelength shift detector. The microdisk laser is coated with a biological or chemical recognition element, which binds preferentially with a target analyte. Because the recognition element and the target analyte adhere to ... 03/02/06 - 20060046311 - Biomolecule analysis using raman surface scanning Methods and apparatus are provided herein for assaying biological samples using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs are Raman-active nanoparticles made up of aggregated primary metal crystal particles with Raman-active organic compounds ... 02/23/06 - 20060040408 - Lateral flow format, materials and methods The present invention provides a lateral flow format and materials and methods for using the format in a variety of applications. More particularly, the present invention provides single-layer lateral flow formats, materials and methods for detecting the presence of an analyte using a test strip comprising a dry porous medium ... 02/23/06 - 20060040407 - Alleviation of non-specific binding in microarray assays A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate during a binding assay. Following incubation, a one-step wash is carried out with a liquid containing digester, e.g., a digestive enzyme (protease) or lysosome, which ... 02/16/06 - 20060035387 - Non-specific binding resistant protein arrays and methods for making the same Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the ... 02/02/06 - 20060024846 - Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released ... 02/02/06 - 20060024845 - Method of immobilizing compound on solid phase support The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without ... 02/02/06 - 20060024844 - Method for the idenification of ligands The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co-regulator dependent target molecule based on the ability to modify the stability of the target molecule. ... 01/26/06 - 20060019408 - Optical biosensors and methods of use thereof A fundamental biosensor for detection of biological or environmental analytes is provided. The biosensor comprises a selectivity component for recognition of a target molecule and a reporter molecule that is sensitive to changes in the microenvironment. Methods of using the biosensor are also provided, including in vivo and in vitro ... 01/19/06 - 20060014302 - Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The ... 01/19/06 - 20060014301 - Antibody-based system for detection of differential protein expression patterns The present invention is a kit and method for identifying the presence or absence of a protein expression profile that is known to be associated with a particular disease or an altered biological state. The method is based on the combination of a known protein expression pattern biomarker with the ... 01/19/06 - 20060014300 - Sensor for detection and identification of biological particles The illustrative embodiment of the present invention is a system and a method for the detection and limited identification of biological agents. The system is small, light weight, requires little power to operate and uses few consumables. The system can be configured for use in either stationary or mobile applications. ... 01/12/06 - 20060008923 - Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The ... 01/12/06 - 20060008922 - Clinical method for the genetic screening of newborns using tandem mass spectrometry and internal standards therefor A method for screening newborns using electrospray tandem mass spectrometry. The method improves the current protocols that use tandem mass spectrometry by assuring accurate and consistent results at the clinical level through enhanced quality controls and quality assurance protocols as applied to the scan profiling and sample preparation of blood ... 01/05/06 - 20060003463 - Methods for assaying or isolating constituents of samples Methods for assaying or isolating constituents of samples include applying a sample to a capillary column, which includes a matrix that includes the same material as a nonporous substrate within which the capillary column is formed, as well as drawing the sample through at least a portion of a length ... 12/15/05 - 20050277204 - Sample preparation methods and devices The present invention provides improved devices for separating and/or detecting targets from biological, environmental, or chemical samples. ... 12/15/05 - 20050277203 - Immunochemical filter device and methods for use thereof The invention provides an immunochemical filter device and use thereof, said filter device comprising a filter material attached to a support member. The filter material comprises a labeled binding reagent, wherein said labeled binding reagent is released from the filter material into solution by migration of a liquid sample solution ... 11/24/05 - 20050260770 - Antigen array and diagnostic uses thereof A method of diagnosing an immune disease, or a predisposition thereto, in a subject is disclosed. The method comprises determining a capacity of immunoglobulins of the subject to specifically bind each antigen probe of an antigen probe set, wherein the antigen probe set comprises a plurality of antigen probes selected ... 11/24/05 - 20050260769 - Handheld medical logging apparatus and method A handheld medical logging apparatus for recording and logging data related to a person's blood glucose level comprises measuring means adapted to measure a glucose level, one or more buttons, and control circuitry coupled to the buttons. The control circuitry is adapted to, in response to an activation of a ... 11/24/05 - 20050260768 - Sequential high throughput screening method and system A method and system for high-throughput screening of multiphase reactions are provided. In an exemplary embodiment the method includes the steps of sequentially loading a plurality of discrete combinations of reactants into a longitudinal reaction zone; reacting each of the combinations as it passes through the reaction zone to provide ... 11/24/05 - 20050260767 - Treatment with cytokines An inflammatory process is suggested to be involved in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by the presence of neuritic plaques within the cerebral cortex that are mainly composed of a small insoluble protein of 40-42 amino acids (amyloid protein). The biological correlates of this process ... 10/20/05 - 20050233473 - Methods and reagents for surface functionalization Reagents and a method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications. ... 10/13/05 - 20050227374 - Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... 10/13/05 - 20050227373 - Method and device for high sensitivity detection of the presence of dna and other probes The present invention provides a method for capacitive detection of the presence of target sample on a substrate, which comprises the steps of: binding a target sample to selective binding sites on the substrate, the target sample being directly or indirectly labeled with conductive labels, and sensing the presence of ... 10/06/05 - 20050221503 - Plasmonic and/or microcavity enhanced optical protein sensing Instruments for molecular detection at the nano-molar to femto-molar concentration level include a longitudinal capillary column (10) of known wall thickness and diameter. The column (10) contains a medium (24) including a target molecule (30) and a plurality of optically interactive dielectric beads (26) on the order of about 10−6 ... 09/08/05 - 20050196877 - Stress-based electrostatic monitoring of chemical reactions and binding Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses ... 09/08/05 - 20050196876 - Detection of biomolecules using porous biosensors and raman spectroscopy The invention provides methods used to analyze the contents of a biological sample, such as blood serum, with cascade Raman sensing. A fluorescence producing nanoporous biosensor having probes that bind specifically to known analytes is contacted with a biological sample and one or more bound complexes coupled to the porous ... 09/01/05 - 20050191762 - Reagents for assays for ligands One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement ... 09/01/05 - 20050191761 - Analyte sensing via acridine-based boronate biosensors Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a ... 08/11/05 - 20050176158 - Process for analyzing the tear fluid The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up ... 08/04/05 - 20050170529 - Metal chelates and methods of using them for time-resolved fluorescence β-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent chelates (complexes) with lanthanide(III) rare earth metal ions (such as Eu3+). ... 08/04/05 - 20050170528 - Binary prediction tree modeling with many predictors and its uses in clinical and genomic applications The statistical analysis described and claimed is a predictive statistical tree model that overcomes several problems observed in prior statistical models and regression analyses, while ensuring greater accuracy and predictive capabilities. Although the claimed use of the predictive statistical tree model described herein is directed to the prediction of a ... 07/28/05 - 20050164411 - Quantitative protein assay using single affinity capture agent for identification and detection This invention discloses a single capture affinity assay and apparatus for the identification and quantification of an analyte in a biological sample. The assay uses an array of affinity capture agents specific for an analyte wherein the analyte is removed prior to detection. After the analyte is bound to the ... 07/28/05 - 20050164410 - Methods and apparatus for improved luminescence assays An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and ... 07/28/05 - 20050164409 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard ... 07/28/05 - 20050164408 - Solid phase isolation of proteins, nucleic acids and other macromolecules The invention is a method for the isolation of molecules of interest using tubes in which at least a portion of the inner walls of the tube are coated with microbeads that are coated with a capture reagent to bind the molecule of interest. The microbeads may be glass or ... 07/28/05 - 20050164407 - Increasing the sensitivity and specificity of nucleic acid chip hybridization tests The invention relates to a method of increasing the sensitivity and specificity of nucleic acid chip hybridization tests and to devices suitable for carrying out the inventive method. ... 07/07/05 - 20050148099 - Immunoassay apparatus and immunoassay method An immunoassay apparatus is described that includes a measuring sample preparing section for preparing a measuring sample by mixing a specimen with carrier particles on which an antibody or an antigen against an analyte is immobilized, a detector for detecting internal information and size information from particles contained in the ... 07/07/05 - 20050148098 - Methods for using raman spectroscopy to obtain a protein profile of a biological sample The invention provides methods for analyzing the protein content of a biological sample, for example to obtain a protein profile of a sample provided by a particular individual. The proteins and protein fragments in the sample are separated on the basis of chemical and/or physical properties and maintained in a ... 06/23/05 - 20050136553 - Self-contained swab-based diagnostic systems A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second end. A swab is disposed at the first end of the stem, the swab ... 06/16/05 - 20050130323 - Inhibitor for adhesion of metal hydroxide-containing substance to waste liquor line of automatic analyzer The present invention provides an inhibitor for adhesion of a metal hydroxide-containing substance to a waste liquid line of an autoanalyzer comprising a polysaccharide; a method of inhibiting adhesion of a metal hydroxide-containing substance to a waste liquid line of an autoanalyzer wherein the inhibitor is used; a reagent for ... 06/16/05 - 20050130322 - Assay device Disclosed is an assay device to determine the presence of at least one analyte of interest in a liquid sample, the device comprising means for generating a first signal (the ‘test’ signal) which indicates the presence and/or amount of analyte of interest in the sample; and means for generating a ... 06/16/05 - 20050130321 - Methods for analysis of spectral data and their applications This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis. ... 06/16/05 - 20050130320 - Method for identifying the proteome of cells using an antibody library microarray The invention describes a method for identifying the level of various proteins in a cells or tissue and also comparing the levels of the same protein in two different tissues which we have termed as Antibody Microarray Proteomics Technology (AMP Technology). Proteins that are differentially expressed between a normal and ... 06/09/05 - 20050124077 - Diagnostic testing process and apparatus A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold ... 06/02/05 - 20050118732 - Immunoassay method for lyzed whole blood The present invention provides an immunoassay method in which blood can be measured even without pretreatment by means of a centrifuge etc. In the present invention, antibodies or antigens in a sample are subjected to agglutination reaction with insoluble carriers onto which antigens or antibodies specifically reacting with the antibodies ... 06/02/05 - 20050118731 - Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions without labels A surface-selective nonlinear optical technique, such as second harmonic or sum frequency generation, is used to detect target-probe binding reactions or their effects, at an interface, in the presence of indicators. In addition, the direction of the nonlinear light is scattered from the interface in a well-defined direction and therefore ... 06/02/05 - 20050118730 - Microchannel array component, microchannel array for recovering biomolecules, and method for recovering biomolecules Various types of biomolecules as the objects of recovery included in a sample solution in minute amounts are separated in accordance with their affinity for various types of probe molecules and readily recovered. A sample solution 8 including biomolecules 7 as the objects of recovery are poured into a microchannel ... 06/02/05 - 20050118729 - Microarrays of cellulose binding chimeric proteins and methods of use thereof The present invention provides microarrays of proteins comprising a cellulose binding region as a means for binding to a cellulase substrate such as cellulose. The cellulose binding region may further contain biologically active exogenous moities introduced therein while maintaining the ability to bind cellulase substrates with high affinity. In addition, ... 06/02/05 - 20050118728 - Two-layer antibody capture system A multimolecular complex that includes an anti-immunoglobulin (anti-Ig) linking antibody reversibly bound to a substrate, a primary antibody bound to the anti-Ig linking antibody to yield an immobilized primary antibody, and optionally, an antigen is bound to the immobilized primary antibody; and a method for immunochemically immobilizing a molecule of ... 06/02/05 - 20050118727 - Conjugates and their use in detection methods Methods for quantitatively or qualitatively detecting an analyte in a sample and suitable reagents for this purpose, in particular to a carrier molecule to which one or more analyte-specific binding partner(s) is/are bonded and which possesses additional binding sites for a specific binding partner X or Y which is associated ... 06/02/05 - 20050118726 - System and method for detecting bioanalytes and method for producing a bioanalyte sensor The present invention discloses an indicator protein, and a method for making such a fusion protien, having a first binding moiety having a binding domain specific for a class of analytes that undergoes a reproducible allosteric change in conformation when said analytes are reversibly bound; a second moiety and third ... ### FreshPatents.com Support |