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Chemistry: Molecular Biology And Microbiology > Process Of Mutation, Cell Fusion, Or Genetic Modification > Introduction Of A Polynucleotide Molecule Into Or Rearrangement Of Nucleic Acid Within A Microorganism (e.g., Bacteria, Protozoa, Bacteriophage, Etc.)

Introduction Of A Polynucleotide Molecule Into Or Rearrangement Of Nucleic Acid Within A Microorganism (e.g., Bacteria, Protozoa, Bacteriophage, Etc.)

Introduction Of A Polynucleotide Molecule Into Or Rearrangement Of Nucleic Acid Within A Microorganism (e.g., Bacteria, Protozoa, Bacteriophage, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

03/15/07 - 20070059836 - Compositions and methods for regulating genes of interest
Compositions and methods for regulating genes of interest are provided. The compositions comprise sense-antisense double stranded nucleic acid molecules, which have homology to a target nucleic acid sequence in a cell. The compositions and methods are useful for the treatment of disease and for preventing the proliferation of neoplastic cells. ...

01/11/07 - 20070010018 - Methods of screening for introduction of dna into a target cell
The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target cells having no useful auxotrophic markers can ...

01/04/07 - 20070004043 - Responses to singlet oxygen
The physiological response of a phototroph to singlet oxygen is altered by modulating the interaction between an anti-sigma factor, ChrR, and a sigma factor, σE, or by altering expression of a gene product required for viability in the presence of singlet oxygen. ...

12/07/06 - 20060275904 - Method for introducing a gene into labyrinthulomycota
An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by ...

11/30/06 - 20060270044 - Compositions and methods for altering cellular functions
The present invention relates to the field of bacteriology. In particular, the invention relates to novel compositions and methods for altering (e.g., inhibiting) the growth and virulence of populations of pathogenic microorganisms. ...

11/30/06 - 20060270043 - Bacteria with reduced genome
The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to about 20% smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for ...

11/09/06 - 20060252155 - methods for site-directed mutagenesis and targeted randomization
The present invention provides methods and compositions for the construction and direct transformation of site-saturation libraries into Bacillus. This method avoids the need for the use of intermediate hosts, such as E. coli for the development of Bacillus strains suitable for the production of proteins. ...

11/02/06 - 20060246589 - Adamts13 genes and proteins and variants, and uses thereof
The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, ...

08/03/06 - 20060172424 - Methods for enhancing expression of recombinant proteins
The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system. ...

08/03/06 - 20060172423 - New expression system from rhodococcus
The present invention provides an isolated polynucleotide comprising the kstD promoter from Rhodococcus erythrypolis. The polynucleotide can very advantageously be used as a controllable transcription activator. Said controlling function can be provided by providing said isolated polynucleotide with a nucleotide sequence encoding a transcription regulator of said promoter. In the ...

06/22/06 - 20060134791 - Compositions and methods for activating genes of interest
Compositions and methods for activating genes of interest are provided. The compositions comprise a masked targeted expression cassette which expresses a gene product only in the presence of a target molecule. The cassettes are useful for the treatment of disease and for preventing the proliferation of neoplastic cells. ...

03/16/06 - 20060057726 - Method for the positive selection of chromosomal mutations in c1 metabolizing bacteria via homologous recombination
A method for the positive selection of allelic exchange mutants is provided for C1 metabolizing bacteria. The chromosomal integration vectors, based on the pGP704 suicide vector, comprise at least one genetic selectable marker and the sacB gene, encoding levansucrase. A one- and two-step selection strategy is provided for the facile ...

02/02/06 - 20060024830 - Growth characteristics of filamentous microorganisms
The invention relates to industrial microbiology, in particular to fermentation technology and especially to fermentation methods for filamentous microorganisms, in particular, filamentous microorganisms such as actinomycetes. The present invention discloses a method for improving the production of a product of interest in a liquid culture of filamentous microorganisms comprising providing ...

01/19/06 - 20060014290 - Inhibition of biofilm formation
The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved ...

01/05/06 - 20060003454 - Non-dividing donor cells for gene transfer
The present invention relates to compositions comprising conjugation-competent non-dividing cells for delivery of genes to bacterial cells by conjugation. The present invention also relates to methods of making, using, and storing such conjugation competent non-dividing cells. ...

12/01/05 - 20050266569 - Regulator/promoter for tunable gene expression and metabolite sensing
A method for the facile and inexpensive inducible expression of heterologous genes has been discovered. The yhcS regulator gene has been found to be inducible by aromatic carboxylic acids and to alter the expression of operons in the LysR gene family, including the yhcRQP operon, common in enteric bacteria. Heterologous ...

08/04/05 - 20050170511 - Oxa1p enhanced protein secretion
The present invention provides methods and compositions for the efficient and enhanced secretion of a protein of interest from a host cell. In specific, proteins are secreted through the Sec-dependent pathway, involving the spoIIIJ and/or yqjG gene product(s). In some embodiments, expression of the spoIIIJ and/or yqjG gene product(s) is ...

06/16/05 - 20050130308 - Cloning and/or sequencing vector
A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison. ...

06/16/05 - 20050130307 - Broad host range pbbr1-based plasmid mutant derivatives having altered plasmid copy number
The present invention describes a mutant plasmid replication control region having the ability to convey a phenotype of altered plasmid copy number to the plasmid on which it resides. The mutant replication control region is based on a similar region isolated from the pBBR1 plasmid family. Plasmids containing this replication ...

06/02/05 - 20050118719 - Nucleic acid delivery and expression
The invention provides methods and materials involved in delivering nucleic acid to cells and regulating expression of nucleic acid in cells. ...



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