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Chemistry: Molecular Biology And Microbiology > Animal Cell, Per Se (e.g., Cell Lines, Etc.); Composition Thereof; Process Of Propagating, Maintaining Or Preserving An Animal Cell Or Composition Thereof; Process Of Isolating Or Separating An Animal Cell Or Composition Thereof; Process Of Preparing A Composition Containing An Animal Cell; Culture Media Therefore > Primate Cell, Per Se > Human > Blood, Lymphatic, Or Bone Marrow Origin Or Derivative Blood, Lymphatic, Or Bone Marrow Origin Or DerivativeBlood, Lymphatic, Or Bone Marrow Origin Or Derivative patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/05/07 - 20070077654 - Platelets from stem cells Human embryonic stem cells are induced to differentiate first into the hematopoietic lineage and then into megakaryocytes, the cells which generate platelets. The proper in vitro culture of megakaryocytes results in the production and shed of platelets. This makes possible, for the first time, the in vitro production of a ... 03/15/07 - 20070059825 - Cytokine zalpha11 ligand antibodies Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller ... 03/15/07 - 20070059824 - Human umbilical cord blood-derived pluripotent fibroblast-like-macrophages The present invention relates to a purified population of fibroblast-like macrophage (f-macrophage, f-MΦ) and methods using the same. The f-MΦ can be expanded in vitro and differentiated into several lineages, including insulin-expressing cells, endothelial cells, and neuronal cells. The f-MΦ described herein have been generated from human umbilical cord blood ... 01/18/07 - 20070015280 - Production of cultured human mast cells and basophils for high throughput small molecule drug discovery Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods generate uniform proliferated populations of cells. The proliferated populations contain a uniform population of a size suitable for use in high throughput screening methods, for ... 12/07/06 - 20060275901 - Method of forming dendritic cells from embryonic stem cells This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. ... 11/09/06 - 20060252151 - Stem cell and dental pulp harvesting method and apparatus Methods and apparatus for recovering dental pulp from dentition of a donor are disclosed, wherein the pulp from within extracted teeth utilizing such methods and apparatus is harvested, while preserving a sterile environment and avoiding trauma and infection, and stem cells, dendritic cells, and other cells isolating from the pulp, ... 11/09/06 - 20060252150 - Human embryonic stem cell cultures, and compositions and methods for growing same Human pluripotential embryonic stem cell cultures are provided, as are human feeder cells useful for growing the human embryonic stem cells, conditioned medium obtained from cultures of the human feeder cells, and factors derived from the conditioned medium. Also provided are methods of growing human embryonic stem cells in the ... 09/21/06 - 20060211112 - Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads A method and apparatus for reproducibly generating dendritic cells are provided. Blood mononuclear cells are loaded into a cell culture container containing microcarrier beads therein. Tissue culture comprising the cells loaded in the container is incubated for a predetermined period. Nonadherent cells and cells adhered to the beads are separated. ... 08/31/06 - 20060194319 - Promoter substitution for immunoglobulin therapy The present invention involves the identification of Bright as involved in immunoglobulin production, and the targeting of that function for the treatment of disease states associated with pathologic immunoglobulin production. Also provided are methods of identifying candidate substances with Bright-inhibitory activity. ... 08/31/06 - 20060194318 - Cultured cd14+ antigen presenting cells The present invention provides isolated CD14+ antigen presenting cells, e.g., dendritic cells and isolated and enriched populations thereof as well as methods for isolation and enrichment. Also provided are methods for using the CD14+ antigenpresenting cells to modulate T cell responses in vivo, in vitro, and ex vivo. ... 08/17/06 - 20060183223 - Continuous flow chamber device for separation, concentration, and/or purification of cells The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive ... 08/10/06 - 20060177929 - Regulation of self-renewal in stem cells Disclosed are methods for regulating the self-renewal capacity of stem cells such as, but not limited to, primitive hematopoietic stem cells (HSCs) (both mouse and human) by modulating the function and/or activity of target factors that are controlled or altered in their regulation by AML1-ETO expression in stem cells such ... 06/22/06 - 20060134784 - Methods and compositions for the growth and maintenance of stem cells The present invention relates to pluripotent stem cells and methods of promoting long term growth of such cells. In particular, the methods described are used to enhance the proliferation of hematopoietic stem cells, hematopoietic precursor cells, hemangioblasts and endothelial stem cells. The present invention also relates to methods of using ... 06/22/06 - 20060134783 - Methods of expanding myeloid cell populations and uses thereof The present disclosure relates to a method of expanding myeloid progenitor cells by culturing an initial population of cells in a medium comprising a mixture of cytokines and growth factors that promote growth and expansion of the myeloid progenitor cells. The expanded cell population provides a source of cells as ... 06/01/06 - 20060115899 - Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use The present invention provides methods for generating mammalian T cell populations comprising antigen-specific CD4+CD25+ regulatory T cells from freshly isolated CD4+CD25− T cells. The method comprises selecting CD4+CD25− T cells from a sample obtained from a mammalian subject; determining the MHC Class II type of the subject; inducing the generation ... 06/01/06 - 20060115898 - Cultured hematopoietic stem cells and method for expansion and analysis thereof Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor (IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said ... 04/20/06 - 20060084170 - Cytokine-free growth and maintenance of progenitor cells The invention pertains to methods and devices for the in vitro culture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors. The hematopoietic progenitor cells are cultured in the absence of exogenously added hematopoietic growth factors without loss in cell progenitor cell numbers and/or functionality, while ... 04/13/06 - 20060078994 - Mature dendritic cell compositions and methods for culturing same This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comprising an interferon gamma receptor (IFN-γR) agonist and/or ... 04/06/06 - 20060073589 - Rapid generation of activated mononuclear antigen presenting cells from monocytes A cell population prepared from blood mononuclear cells, the mononuclear cells being peripheral blood mononuclear cells (PBMC) or CD 14+ monocytes, the population containing from about 10% to about 50% of activated mononuclear antigen presenting cells (APCs) having the following characteristics: • they express surface markers CD2, CD83 and CD14, ... 03/23/06 - 20060063256 - Human regulatory t cells and uses thereof Regulatory T cell subpopulation (Treg) are isolated for a human host by selection for cells expressing CD4 and CD25. The Treg cells are further characterized by expression of CTLA-4, CCR6, and CD30. In addition, the Treg cells are CD62Lhi, CD45RBlo, CD45ROhi, CD45RA−. The Treg cells of the invention reflect the ... 03/16/06 - 20060057722 - Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment A therapeutic composition is provided that comprises a cell-free conditioned medium containing mixed secretion products of isolated angiogenic progenitor cells obtained from bone marrow, peripheral blood, or adipose tissue. The composition may additionally contain angiogenesis-promoting proteins obtained by transfecting the progenitors cells in culture with an angiogenesis promoting transgene. The ... 02/16/06 - 20060035374 - Method and device for multiplying and differentiating cells in the presence of growth factors and of a biological matrix or of a supporting structure The invention relates to an in-vitro and in-vivo method for multiplying and differentiating cells, during which the growth process of the cells is initiated or terminated and structurally directed by the use of growth factors thrombopoietin (TPO) and/or erythropoietin (EPO), and/or growth hormone (GH), particularly human growth hormone (HGH), and/or ... 02/02/06 - 20060024825 - Method of promoting expansion of stem cells The present application discloses a method for expanding a population of mammalian cells comprising contacting the cells with angiopoietin 1. ... 12/29/05 - 20050287666 - Cell culture medium comprising transition metals or trace elements The present invention provides improved cell culture media, media supplements, methods of manufacture of said media and methods of culturing cells. Transition metals or trace elements are controlled in a manner to provide improved conditions for culturing cells. Also provided are methods for supplementing media to improve culture and the ... 12/22/05 - 20050282277 - Methods of increasing platelet and hematopoietic stem cell production A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed. ... 12/08/05 - 20050272152 - Stem cell populations and methods of use The invention provides populations of expanded CD34-expressing cells and methods of use. Particular embodiments provide for defined culture media useful for growing these cells, and grafts comprising these cells. The invention finds use in methods for reconstituting, repairing, and regenerating tissue damage. ... 12/08/05 - 20050272151 - Dendritic cell line The invention relates to plasmacytoid dendritic human cell lines (pDC), methods for the production thereof and to said cells. More specifically, said invention relates to the plasmacytoid dendritic human cell line called GEN2.2 which is deposited in CNCM under number CNCM I-2938. The use of said cells and pharmaceutical compounds ... 12/01/05 - 20050266557 - Method of expanding cord blood cells Based on previous evidence suggesting positive effects of fever on in vivo hematopoiesis, the effect of hyperthermia on the expansion and differentiation of megakaryocytes (MKs) in ex vivo cultures of CB CD34-enriched cells has now been tested. Cells were cultured at 37° C. or 39° C. for 14 days in ... 12/01/05 - 20050266556 - Isolation, expansion and use of clonogenic endothelial progenitor cells A hierarchy of endothelial colony forming cells (EPCs) was identified from mammalian cord blood, umbilical vein and aorta. A newly isolated cell named high proliferative potential—endothelial colony forming cell (HPP-ECFC) was isolated and characterized. Single cell assays were developed that test the proliferative and clonogenic potential of endothelial cells derived ... 11/24/05 - 20050260751 - Pluripotent adult stem cells The invention relates to isolated human pluripotent adult stem cells which express CD13, CD34, CD56 and CD117, and which do not express CD10, which are capable of differentiating in all three germ lineages; differentiated cells derived therefrom; and methods of use. ... 11/17/05 - 20050255593 - Bone marrow stromal cell-derived schwann cells There is provided a method of inducing bone marrow stromal cells to differentiate into bone marrow stromal cell-derived Schwann cells in vitro, comprising the steps of: collecting bone marrow stromal cells from bone marrow and culturing the cells in a standard essential culture medium supplemented with a serum; adding a ... 11/17/05 - 20050255592 - Multi-lineage progenitor cells Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described. ... 11/10/05 - 20050250204 - Methods and apparatus for separation of particles The present invention relates to a method for separating particles. The invention has particular advantages in connection with separating and purifying progenitor cells or stem cells obtained from bone marrow. The method comprises removing a desired volume of stem cell staring product from a donor/patient and eluting off a first ... 10/20/05 - 20050233453 - 6-o-sulfated n-acetylheparosan and hematopoietic stem cell growth auxiliary agent A 6-O-sulfated N-acetylheparosan in which a primary hydroxyl group of N-acetylglucosamine constituting N-acetylheparosan is sulfated; a hematopoietic stem cell growth auxiliary agent, which has hematopoietic stem cell growth-accelerating activity and comprises the 6-O-sulfated-N-acetylheparosan as an active ingredient; a medium for a hematopoietic stem cell, which comprises the hematopoietic stem cell ... 10/20/05 - 20050233452 - Cell populations which co-express cd49c and cd90 Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are ... 10/20/05 - 20050233451 - Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer A method of preparing autologus T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs) from a patient immunized with an antigen of the cancer, stimulating the PBMCs with the antigen of the cancer in vitro, transducing the PBMCs with a retrovial vector, ... 10/13/05 - 20050227354 - Process for producing cytotoxic lymphocyte The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof. ... 10/06/05 - 20050221483 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for ... 10/06/05 - 20050221482 - Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof The present invention provides an isolated population of adult hematopoietic stem cells (HSC) derived from embryonic stem cells (ESC) induced to differentiate in vitro by culturing ESCs in a medium with stem cell factor, interleukin (IL)-3, and IL-6. HSC of immunophenotype c-kit+ or c-kit+/CD45+ from this population are isolated and ... 10/06/05 - 20050221481 - Amplification of t cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2 The present invention relates to a method of ex vivo amplification of neonatal T cells from umbilical cord blood which comprises obtaining light density mononuclear cells from a sample of umbilical cord blood and then culturing said light density mononuclear cells in a serum-deprived culture medium supplemented with various cytokine ... 09/29/05 - 20050214942 - Activation and expansion of cells The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in ... 09/22/05 - 20050208655 - Blood cells having modified antigenicity This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique alpha N-acetylgalactosaminidases and alpha-galactosidases with superior kinetic properties for ... 09/22/05 - 20050208654 - Process for producing t lymphocytes The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts. ... 09/08/05 - 20050196860 - Novel eps8 compounds for therapy and diagnosis and methods for using same The present invention provides methods and compositions for detecting, diagnosing, prognosing and monitoring the progress of EPS8-related cancers and malignancies and kits for use in said methods. Further provided are methods for screening to identify agonists and antagonists of cancer antigens associated with EPS8-related cancers and malignancies. ... 08/18/05 - 20050181504 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the ... 08/11/05 - 20050176143 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic stem cells; and (b) culturing the undifferentiated hemopoietic stem cells in a medium containing a stromal cell conditioned medium, the stromal cell conditioned ... 08/11/05 - 20050176142 - Mammalian megakaryocyte progenitor cell A substantially enriched mammalian hematopoietic cell population is provided, which is characterized as a progenitor cell committed to the megakaryocyte lineage. Methods are provided for the isolation and culture of these cells. The cell enrichment methods employ reagents that specifically recognize CD9 and CD41, in conjunction with other markers expressed ... 08/04/05 - 20050170503 - In vitro induction of antigen-specific t-cells using dendritic cell-tumor cell or dendritic cell-viral cell derived immunogens Antigen-specific T-cells prepared by culturing T-cells in formulations comprising combinations of DCs and either tumor cells or virally infected cells are disclosed. These formulations generally comprise hybridoma of at least one dendritic cell fused to either at least one tumor cell or at least one virally infected cell, or co-cultures ... 07/28/05 - 20050164387 - Modified rapid expansion methods (modified-rem) for in vitro propagation of t lymphocytes The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater ... 07/21/05 - 20050158858 - Growth factor therapy mobilization of stem cells into the periperal blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral blood stem cells (PBSC) by ... 07/21/05 - 20050158857 - Hematopoietic stem cell identification and isolation The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, ... 07/21/05 - 20050158856 - Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce ... 07/14/05 - 20050153447 - Activation and expansion of cells The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in ... 07/07/05 - 20050148074 - Progenitor cells from wharton's jelly of human umbilical cord Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC−/− progenitor cells, and is useful to grow and repair human tissues including bone. ... 06/16/05 - 20050130304 - Regulation of endogenous gene expression in cells using zinc finger proteins The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. ... 06/16/05 - 20050130303 - Stimulation of hematopoiesis by ex vivo activated immune cells A protocol of activating and administering human blood cells so that bone marrow histology and/or blood cell counts of patients suffering from a plastic anemia approach normal. The protocol includes culturing the blood cells in the presence of a cytokine and an ionophore. It is emphasized that this abstract is ... 06/16/05 - 20050130302 - Method and composition for regulating expansion of stem cells A method and substance for regulating expansion of a stem cell, such as a hematopoietic stem cell, is provided. Therefore, a method is provided for regulating expansion of a stem cell, such as a hematopoietic stem cell, a germ line stem cell, or a neural stem cell, comprising the steps ... 06/16/05 - 20050130301 - Isolation of bone marrow fraction rich in connective tissue growth components and the use thereof to promote connective tissue formation A bone marrow isolate rich in one or more connective tissue growth components, methods of forming the isolate, and methods of promoting connective tissue growth using the isolate are described. A biological sample comprising bone marrow is centrifuged to separate the sample into fractions including a fraction rich in connective ... 06/02/05 - 20050118714 - Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood and differentation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues The present invention relates to a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method comprises the steps of: overlaying umbilical cord blood ... ### FreshPatents.com Support |