Measuring Or Testing For Antibody Or Nucleic Acid, Or Measuring Or Testing Using Antibody Or Nucleic Acid

Measuring Or Testing For Antibody Or Nucleic Acid, Or Measuring Or Testing Using Antibody Or Nucleic Acid patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

04/19/07 - 20070087431 - Cassette for sample preparation
A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample. ...

04/19/07 - 20070087430 - Method and apparatus for detection of biological organisms using raman scattering
A system for the detection of compounds, including a target biological organism or component from a sample, using one or more reactant that will bind to the biological organism or compound forming a Raman active product, concentrating the Raman active product, and detecting the Raman active product using Raman light ...

04/19/07 - 20070087429 - Reaction disk and separation cell for automatic analyzer
[Selected Drawing] FIG. 3 ...

04/12/07 - 20070082389 - Sample homogeniser
An apparatus for comminuting or homogenising biological tissue, comprising a container (1) with an interior bottom (5) comprised of an abrasive surface (6) a cap (10), and a grinder (20) receivable in the interior (2) of the container (1). Wherein the grinder (20) comprises a grinding head (21) and a ...

04/05/07 - 20070077645 - Biochemical treatment device with dispensing unit
The width of reaction wells and detection wells used for the same sample in a nozzle line direction is made to fall within an area smaller than the pitches of nozzle holding parts, so as to minimize a moving range and enable a pipette action for preventing contamination. ...

04/05/07 - 20070077644 - Bioassay substrate with feeder wirings
Provided is a configuration of feeder wirings for electrodes provided for reaction regions arranged in multiplicity on a disk-shaped substrate. Feeder wirings extended from a current passing portion (U) provided at a central portion of a substrate (A) to electrodes provided in reaction regions (R) arranged in multiplicity on the ...

03/29/07 - 20070072287 - Biomems cartridges
A cartridge includes a first layer to receive a printed circuit board hosting a biochip. A second layer is connected to the first layer and is configured for sample injection to the biochip. The second layer includes a first septum to isolate fluidic ports. A third layer is connected to ...

03/29/07 - 20070072286 - Label-free detection of biomolecules
The invention provides a method and a device for label-free detection of biomolecules or analytes in a sample liquid. The method comprises the steps of allowing an analyte to bind to one of at least two conductive surfaces. An alternating electrical field between at least two conductive surfaces. Amplitude and ...

03/22/07 - 20070065935 - Polymeric microarray support, method of forming microfeatures on an optical assay arrangement
The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth ...

03/15/07 - 20070059817 - Biochemical reaction cassette with improved liquid filling performance
A biochemical reaction cassette comprises a housing member, a reaction chamber arranged in the housing member and having a bottom section and a ceiling facing the bottom section, an injection port arranged at the ceiling of the reaction chamber, a discharge port arranged at the ceiling of the reaction chamber ...

03/08/07 - 20070054392 - Method for characterizing a surface, and device therefor
The present invention relates to a method of characterizing a surface and to a device for implementing this method. In particular, this method makes it possible to measure, qualitatively and/or quantitatively, interactions that may be physical, chemical, biochemical or biological. ...

03/08/07 - 20070054391 - Dna detection device and manufacturing method thereof
A DNA (Deoxyribo Nucleic Acid) detection device and a manufacturing method thereof detects DNA by an electrical method without a separate process for detection by using semiconductor microfabrication techniques. The DNA detection device includes a pair of chambers formed on a semiconductor substrate for accommodating a detection sample, a channel ...

03/01/07 - 20070048858 - Low adsorption surface
A device comprising an analytical sample substrate having at least one region that comprises a plurality of sample-support-structures. Each of the sample-support-structures have at least one dimension of about 1 millimeter or less. A sum of areas of contact surfaces of the sample-support-structures is substantially less than a total area ...

02/22/07 - 20070042489 - Self-contained assay device for rapid detection of biohazardous agents
The invention relates to self-contained assay cassette for detecting a ligand in a sample. The assay cassette provides for turbulent flow and mixing of the sample with assay components, including receptors that bind to a ligand, optional microspheres capable of binding the receptors or to which other secondary receptors are ...

02/15/07 - 20070037274 - Microarray synthesis instrument and method
During the light illumination period of a monomer addition cycle in synthesizing an DNA microarray, undesirable reflections of illumination light from various interfaces that the illumination light passes through near the synthesis surface of the substrate may reduce the light-dark contrast, and negatively affect the precision and resolution of the ...

02/15/07 - 20070037273 - Devices and methods for pharmacokinetic-based cell culture system
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ...

02/15/07 - 20070037272 - System for optically analyzing a substance
A microfluidic analysis system for optically analyzing a substance includes a light source having a plurality of selectable single-wavelength light sources, a substance presentation member optically coupled to the light source, and an optical detection system associated with the substance presentation member. ...

02/08/07 - 20070031961 - Biosensors and methods for their use
The invention disclosed herein provides biosensors and methods which increase the sensitivity of assays of optically labelled molecules fluorescently tagged polypeptides and polynucleotides while decreasing the sample volume required for detection. By integrating reflective sidewalls into the receptacles used in such assays, the signal-to-noise ratio of the optical signal is ...

02/08/07 - 20070031960 - Optical cuvette with platform-and-well construction
Formats for optical analysis of fluid samples are provided with platforms and wells for contacting fluid samples and bringing reagents in contact with fluid samples. Formats may be made in opposing platform-and-well constructions, allowing a platform protruding from one format member to enter a well contained within an opposing format ...

01/25/07 - 20070020749 - Materials and methods for creating imaging layers
The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some ...

01/04/07 - 20070004031 - Microfluidic device and methods of using same
A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited ...

01/04/07 - 20070004030 - Flow cell device, sensor unit and assay apparatus
A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface with a sensing surface for detecting reaction of sample. Two flow channels are formed in ...

01/04/07 - 20070004029 - Biochemical reaction cassette
A biochemical reaction cassette is designed to uniformize the flow of liquid in the reaction chamber by using a simple additional arrangement. A member for reducing the cross sectional area of the flow channel that includes an injection port, a reaction chamber and a discharge port is arranged in the ...

01/04/07 - 20070004028 - Signal measuring system for conducting real-time amplification assays
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a ...

01/04/07 - 20070004027 - Method for manufacturing a biosensor element
When probe biomolecules are immobilized on a substrate surface, a surfactant (phase transfer catalyst) is added for reaction, whereby immobilization efficiency of the probe biomolecules and coating uniformity thereof are improved. Consequently, it is possible to dramatically improve quantitativity and reproducibility of the biosensor element. ...

12/28/06 - 20060292686 - Analyte recovering device, and analyte recovering method
An analyte recovering device which supplies an analyte solution containing an analyte to a flow path including a substantially flat face on which a ligand is attached, for binding the ligand and the analyte in the analyte solution with each other, and recovering the bound analyte is provided. The device ...

12/21/06 - 20060286663 - Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
The invention provides methods for fabricating calorimetric resonant reflection biosensors. ...

12/21/06 - 20060286662 - Medical diagnostic test strip
A medical diagnostic test strip is disclosed, which comprises: a top plate, having at least a cell arranged therein for storing an enzyme, each cell having at least a microchannel channeling out to the outer rim of the top plate therefrom while enabling one of the plural microchannel to guide ...

12/14/06 - 20060281170 - Localized plasmon resonance sensor
A localized plasmon resonance sensor for detecting a change in optical constant uses a structure including metal. In a response spectrum with respect to light incident on the structure, there are at least two resonance peaks including at least one resonance peak shifted to a longer wavelength side and at ...

12/07/06 - 20060275892 - Reaction vessel, reaction apparatus and detection apparatus using the same, and method of manufacturing reaction vessel
A reaction vessel includes a three-dimensional substrate on which a probe applied to detection of a biorelated substance is immobilized, a coupling portion allowed to be coupled to a liquid driver in an airtight fashion, and a solution sucking portion allowed to suck a solution. The coupling portion and the ...

12/07/06 - 20060275891 - Apparatus and method for reading fluorescence from bead arrays
When detecting fluorescence of a bead chip array, reflected light from a bead is detected at the same time, so as to recognize the bead position. The reflected light can be detected in a similar manner for all beads, regardless of the presence or absence of a fluorescent substance. If ...

12/07/06 - 20060275890 - Method of manufacturing a disposable diagnostic meter
A method for manufacturing a diagnostic testing system is provided. Various methods are described for calibrating the test system to work with selected test media compatible with the calibration to provide accurate results. The methods eliminate the need for any kind of user-coding. Packaging only compatible selected diagnostic test media ...

11/30/06 - 20060270022 - Methods and apparatus for amplification of dna using sonic energy
Apparatus and methods for amplification of DNA are provided that use sonic energy in place of conventional thermocyclers. In one embodiment, sonic energy is applied to a PCR cocktail to effect dissociation of double stranded DNA into single strands of DNA. A quiescence stage, where no sonic energy is applied, ...

11/23/06 - 20060263874 - Apparatus and method of assay in utilizing attenuated total reflection
A surface plasmon resonance (SPR) assay apparatus has an assay stage, which is loadable with a sensor unit. The sensor unit has a prism, thin film, flow cell and flow channel for flow of sample. A multiple pipette assembly accesses the flow channel in the assay stage, and introduces the ...

11/23/06 - 20060263873 - Controlled flow microfluidic device and method of fabrication
The invention comprises a method and device for cell culture analysis using microporous membranes to control fluid flow in a device. The microporous membranes are of defined porosity and surface area to effectively increase the fluidic circuit resistance and control fluid flow through the device. ...

11/23/06 - 20060263872 - Spectrophotometric method and apparatus
Disclosed is a spectrophotometry for a spectral transmission measurement of an extremely small volume of sample solution. A sampler 15 is formed of a flat plate member formed with a sample-holding hole 152 which penetrates the flat plate member in its thickness direction and has a reverse truncated cone shape, ...

11/16/06 - 20060257996 - Analyte sensing biointerface
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a ...

11/16/06 - 20060257995 - Analyte sensing biointerface
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a ...

11/16/06 - 20060257994 - Device for capturing beads and method and apparatus for arraying beads
Beads having diameters of several tens of micrometers to several millimeters and immobilized with biomolecules are captured by one kind of bead capturing nozzle one by one without fail. Using a bead holding plate having a plurality of wells each of which holds a plurality of the beads and a ...

11/16/06 - 20060257993 - Integration of fluids and reagents into self-contained cartridges containing sensor elements
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or ...

11/16/06 - 20060257992 - Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or ...

11/16/06 - 20060257991 - Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or ...

11/02/06 - 20060246576 - Fluidic system and method for processing biological microarrays in personal instrumentation
A fluidic system and method for processing biological sensors. The fluidic system includes a fluidic component including at least a first container and a second container. The first container is capable of holding a first volume of a first fluid, and the second container is capable of holding a second ...

11/02/06 - 20060246575 - Microfluidic rare cell detection device
The present invention relates to microfluidic devices and methods for detecting rare cells. The disclosed microfluidic devices and methods integrate and automate sample preparation, cell labeling, cell sorting and enrichment, and DNA/RNA analysis of sorted cells. ...

11/02/06 - 20060246574 - Dispenser for making a lateral flow device
A dispenser for building a lateral flow immunoassay device comprises a fluid supply assembly and a jetting assembly. The fluid supply assembly comprises an antibody component including a plurality of reservoirs to supply at least one of member of a group comprising a species array of at least one species-specific ...

11/02/06 - 20060246573 - Bio-chip
A biological molecule biochip that supports biological molecules between a first member and a second member; in either the first member or the second member, by forming a plurality of grooves in parallel in a face that makes contact with the other member, a plurality of spaces are provided that ...

10/26/06 - 20060240542 - Substrate support lift mechanism
An apparatus for positioning a substrate support within a processing chamber is provided. In one embodiment, an apparatus for positioning a substrate support includes a yoke comprising a curved surface with a first slot formed therethrough, a base comprising a first surface adapted to support the substrate support and a ...

10/26/06 - 20060240541 - Lateral flow assay systems and methods
In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of ...

10/26/06 - 20060240540 - Biosensor, biosensor chip, and biosensor device
A biosensor device includes a biosensor having a plurality of biosensor sections each including a working pole and a counter pole. The biosensor device further includes a singal processing circuit for measuring a current flowing from the working pole when different voltages are applied between the working poles and the ...

10/19/06 - 20060234371 - System and method for processing large number of biological microarrays
A system and method for processing biological sensors. The system includes a support component configured to support a fluidic component. The fluidic component includes at least a first container and a second container. The first container is capable of holding a first volume of a first fluid, and the second ...

10/19/06 - 20060234370 - Analysis and culture apparatus
An analysis and culture apparatus including several wells, which have a cover that closes the well to form a closed space, as well as at least one inlet passage and one outlet passage for introducing matter to a closed space and for removing it from a closed space, respectively. The ...

10/05/06 - 20060223171 - High sensitivity mechanical resonant sensor
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first resonant frequency is determined for ...

10/05/06 - 20060223170 - Biomolecule detecting apparatus and biomolecule detecting method employing the same
A biomolecule detecting element capable of easily immobilizing a detecting probe and being used in a simple manner without requiring a dark box and the like. A biomolecule detecting probe is immobilized on the surface of a conductive electrode of an insulated gate field effect transistor, the conductive electrode being ...

10/05/06 - 20060223169 - Multiplex fluorescence detection device having removable optical modules
Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a ...

10/05/06 - 20060223168 - Integrated cmos-compatible biochip
A device for analyzing a fluid sample is provided. The device includes a substrate, a trench formed in said substrate, and a processor. The trench includes a channel, a sample chamber, and a reagent chamber, each in fluid communication with each another. The sample chamber is configured to receive the ...

10/05/06 - 20060223167 - Biochip support comprising thin layers of sol-gel material and production method thereof
The invention relates to a biochip support comprising a substrate supporting at least one porous layer of material on a first face, the said layer being designed to fix biological molecules onto the said layer and in the volume of this layer, the said support being characterized in that the ...

09/28/06 - 20060216817 - Test device for analyzing body fluids
A test instrument for analyzing body fluids such as blood or urine. The instrument includes a wound test tape which can be transported from a storage space into a waste space by advancing the tap. The test tape has a plurality of test sections to which body fluid can be ...

09/28/06 - 20060216816 - Flow path system provided with reaction section suited for the detection of hybridization, and hybridization detecting device making use of the flow path system
A flow path system suitable for use in the detection of hybridization includes a capillary provided at a predetermined location thereof with a reaction section packed with beads. On the beads, a linker having a sequence of bases of the same type is immobilized, and a target nucleic acid complementarily ...

09/28/06 - 20060216815 - Oxidation resistane strcuture for metal insulatormetal capacitor
A method of fabricating an integral device of a biochip integrated with micro thermoelectric elements and the apparatus thereof is disclosed. The micro thermo-electric biochip includes a micro thermoelectric temperature control unit and a biochip unit, and both of the two units can be manufactured by using the fabricating method. ...

09/28/06 - 20060216814 - Molecule detecting method, molecule counting method, molecule localization detecting method, and molecule detecting device used for them
The present invention relates to a molecular detection method in which a chain molecule immobilized on a substrate is visualized and identified by probing with a scanning probe microscope in solution. Furthermore, the present invention relates to a system for detecting a chain molecule immobilized on a substrate, the system ...

09/28/06 - 20060216813 - Dna chip comprising a microarray made of an microelectrode system
A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the ...

09/14/06 - 20060205062 - Microfluidic analysis system
A microfluidic analysis system (1) performs polymerase chain reaction (PCR) analysis on a bio sample. In a centrifuge (6) the sample is separated into DNA and RNA constituents. The vortex is created by opposing flow of a silicon oil primary carrier fluid effecting circulation by viscous drag. The bio sample ...

09/14/06 - 20060205061 - Biosensors based upon actuated desorption
Provided are methods and systems for a rational concatenation of specific classes of proven microfluidic-based protocols to enable a systems approach to repetitive, synchronous analyte detection via a pristine detection array under programmed and/or automatic control. ...

09/14/06 - 20060205060 - Biosensor, biosensor system and method of using thereof
A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared ...

09/14/06 - 20060205059 - Dual path immunoassay device
The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or ...

08/31/06 - 20060194306 - System for gel electrophoretic immunoassay
A micro-analytical platform for performing electrophoresis-based immunoassays was developed by integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device. The microfluidic immunoassays are performed by gel electrophoretic separation and quantifying analyte concentration based upon conventional polyacrylamide gel electrophoresis (PAGE). To retain biological activity of proteins and maintain intact immune complexes, ...

08/24/06 - 20060188979 - Method and apparatus for improved temperature control in microfluidic devices
A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperature of the fluid within the microchannels is controlled in various ways ...

08/17/06 - 20060183217 - Cartridge for automatic measurement and measuring device using the same
An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a ...

08/03/06 - 20060172409 - Micro-reactor, dissociation constant measuring apparatus, dissociation constant measuring method, and dissociation constant measuring program
In order to make it possible to predict a dissociation constant at an initial stage of reaction, a concentration sensor for a sample is provided on a downstream side of a mass sensor. This makes it possible to learn concentration of a sample solution at the time when a mass ...

08/03/06 - 20060172408 - Device for immobilizing chemical and biochemical species and methods of using same
A substrate is provided that facilitates immobilization of nucleic acid molecules, including DNA molecules and RNA molecules. Also provided is a device that includes the substrate, which, for example, can be a chip. In addition, methods of using the substrate are provided, including, for example, methods of sequencing a DNA ...

07/20/06 - 20060160210 - Biological sample analysis plate
In a biological sample analysis plate, one ends of channels 11 and 12 are connected to a quantitative sorting part 10 having a predetermined volume for taking a predetermined amount of a biological sample. On the other end of the channel 11, a buffer agent storage part 7 for holding ...

07/20/06 - 20060160209 - Systems and methods for measurement optimization
The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein. ...

07/20/06 - 20060160208 - Multi-well plate with alignment grooves for encoded microparticles
A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of ...

07/20/06 - 20060160207 - Cucurbituril derivative-bonded solid substrate and biochip using the same
The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used to link biomaterials to the substrate. Protein chips, gene chips, and sensors for ...

07/20/06 - 20060160206 - Parallel prosessing of microfluidic devices
Microfluidic arrangement which comprises A) a number of microfluidic devices, and B) an instrument which comprises a spinner motor and a rotary member arranged such that liquid flow can be driven centrifugal force in each of the devices by spinning the. Each of the microfluidic devices comprises microchannel structures in ...

07/20/06 - 20060160205 - Devices and methods for biochip multiplexing
The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples. ...

07/13/06 - 20060154360 - Hybridization system using the control of pump and valves in closed system
Provided is a hybridization system for hybridizing a biochip including: a chamber device including at least a hybridization chamber including a support for a biochip and a first cover having a sample inlet; an agitation device including: two air channels connected to ends of the hybridization chamber; two valves disposed ...

07/06/06 - 20060148067 - Bio-bonding detection apparatus using ultrasonic waves and method thereof
An apparatus for detecting bio-bonding using ultrasonic waves and a method thereof are disclosed. The apparatus includes a generator for generating ultrasonic wave, a transformer, disposed in proximity to the generator, the transformer configured for vibration thereof by the generated ultrasonic wave. A probe biomolecule is immobilized on the transformer, ...

07/06/06 - 20060148066 - Electrospun nanofibrous membrane assembly for use in capturing chemical and/or biological analytes
A membrane assembly adapted for use in capturing an analyte of interest, the membrane assembly comprising in one embodiment (a) an electrospun nanofibrous membrane, the electrospun nanofibrous membrane comprising a random mat of electrospun nanofibers, at least some of the electrospun nanofibers including one or more types of functional groups; ...

07/06/06 - 20060148065 - Collection of micro scale devices
A collection of one or more microfluidic devices which together carry a plurality of microchannel structures each of which comprises a reaction microcavity (104a-h) in which there is a solid phase with an immobilized affinity ligand L, characterized in that (i) the plurality is divided into sets of microchannel structures, ...

07/06/06 - 20060148064 - Apparatus and method for immunotherapy of a cancer through controlled cell lysis
The treatment device includes an extraction mechanism, configured to extract a tissue sample from a patient or a tumor, coupled to a lysis mechanism. The lysis mechanism is configured to induce lysis of the tissue sample into a lysed tissue sample. The treatment device also includes an administration mechanism that ...

06/29/06 - 20060141612 - Automated method of manufacturing polymer arrays
The present invention provides methods to process multiple sensors by providing a sensor plate and HT plates. In a preferred embodiment of the invention, methods for assembling microarray pegs and microarray plates are described for high throughput microarray processing. ...

06/29/06 - 20060141611 - Spatially scanned optical reader system and method for using same
An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). ...

06/29/06 - 20060141610 - Microarray devices having controllable reaction volume
This invention relates generally to the field of microarray reaction devices and uses thereof. In particular, the invention a microarray reaction device wherein a plurality of reaction spaces are formed between a first and second plurality of projections, the heights of said plurality of reaction spaces being substantially identical and ...

06/22/06 - 20060134775 - Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore
Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore are provided. One system configured to measure fluorescence of particles includes an illumination subsystem configured to illuminate the particles with light having linear polarization oriented in a non-vertical direction, circular polarization, or elliptical polarization. The polarization of the ...

06/22/06 - 20060134774 - Detection of protease enzymes
Methods and compositions for the detection of biomolecules, for example, proteases, are provided. The novel compositions, methods, and kits of the present invention have broad applicability in the detection of proteases, and providing enhanced specificity in the detection of proteases. The compositions and methods may be used to measure the ...

06/15/06 - 20060128007 - Device and method for multiple analyte detection
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid ...

05/25/06 - 20060110821 - Devices for motile sperm separation
Device (10, 110) for separating motile sperm from a sample (100, 200), comprises a vessel (15, 115) having an inlet port (20, 120), an outlet port (35, 135) which is initially closed, a medium (40, 140) into which motile sperm in the sample (100, 200) can migrate into the vessel ...

05/25/06 - 20060110820 - Capturing apparatus and method of minute objects
A capturing apparatus that captures plural minute objects that float on a fluid, includes a capturing part that includes plural attraction ports, each of which can attract each object, wherein attractions by the plural attraction ports are independent of each other. ...

05/25/06 - 20060110819 - Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces
The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in ...

05/18/06 - 20060105449 - Biochip having an electode array on a substrate
A biochip for electrical, e.g., capacitive, detection of biochemical molecules has an electrode array on a substrate, the electrodes of the electrode array being each connected through the substrate to an electrically conductive contact surface via an electrical conductor. The contact surfaces are situated on the side of the substrate ...

05/11/06 - 20060099704 - Method for providing protein microarrays
The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein micorarray can ...

05/04/06 - 20060094108 - Thermal cycler for microfluidic array assays
A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of ...

04/27/06 - 20060088929 - Micro-reactor for gene inspection
After lysing a bacterial cell in the specimen by bacteriolysis reagent stored in bacteriolysis reagent storage section 3, and after adsorbing bacterial genes on carriers filled in carrier filling section 4, there is conducted preliminary processing for washing and detecting bacterial genes. Further, there are provided a control means that ...

04/13/06 - 20060078986 - Analytical devices with primary and secondary flow paths
The present invention provides analytical devices comprising primary and secondary flow paths. A secondary flow path is configured to allow for a portion of a liquid sample to enter the secondary flow path from a primary flow path and subsequently be drawn back into the primary flow path, thereby providing ...

04/13/06 - 20060078985 - Device and method for quantitatively measuring immobilized sample
Evaluation of an amount of immobilized sample in a surface plasmon resonance (SPR) immunoassay is provided. To immobilize the sample, a sensor unit has a sensing surface. The sensor unit includes a transparent dielectric medium, and a metal film having the sensing surface. The metal film is connected with the ...

04/13/06 - 20060078984 - Sensors for biomolecular detection and cell classification
A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent ...

03/30/06 - 20060068491 - Microdevice for performing method of separating and purifying nucleic acid
A microdevice for performing a method for separating and purifying a nucleic acid, the microdevice comprising: at least one opening; and at least one channel for passing a sample solution, wherein the method comprises: (A) a step of bringing a nucleic acid-containing sample solution into contact with a nucleic acid-adsorbing ...

03/30/06 - 20060068490 - Flow-through chemical and biological sensor
The invention provides a mixing flow apparatus. The mixing flow apparatus consists of a waveguide and a mixing flow chamber; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal, and the mixing flow chamber having a body forming a flow chamber with ...

03/16/06 - 20060057709 - Plate and test method using the same
A flow path is formed in a zigzag shape to have a predetermined width from an upstream side to a downstream side. Accordingly, both side surfaces of the flow path divide the flow path into a plurality of regions from the upstream side to the downstream side to function as ...

03/16/06 - 20060057708 - Testing plate
Light shielding portions are provided along a flow path on a top surface of a plate substrate at both sides, that is, an X1 side (right side) and an X2 side (left side) of the flow path. Then, when a fluorescent intensity is measured to determine whether a test sample ...

02/23/06 - 20060040380 - Bioarray chip reaction apparatus and its manufacture
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the ...

02/23/06 - 20060040379 - Biochip cartridge and biochip reader
A biochip cartridge has a vessel and a lid portion having a plurality of microlenses. A biochip having a plurality of sites is provided in the vessel. The plurality of sites are to be disposed at the same pitches as the microlenses. Excitation light is applied to each of the ...

02/23/06 - 20060040378 - Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules
A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated ...

02/23/06 - 20060040377 - Protein microarrays
Methods for making a microarray having minimal background binding of proteins by appropriately coating a substrate surface which is initially derivatized with organic functional groups. A protein-resistant polymeric coating is applied which has hydrophilic backbone polymers that are crosslinked to a substantial degree via polyfunctional isocyanate moieties. Three dimensional hydrogel ...

02/09/06 - 20060030034 - Arrays with elongated features
Arrays having multiple biopolymer features on a substrate, including elongated features which have a length/width ratio greater than 1.3 or more. Such arrays may be oriented in various directions and of shapes described, and fabricated using apparatus, methods, or computer program products of the invention. ...

02/09/06 - 20060030033 - Label-free high-throughput optical technique for detecting biomolecular interactions
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ...

02/09/06 - 20060030032 - Three-phase tilting agitator for microarrays
A low-cost, easy to operate, three-phase tilting agitator for microarrays, including large area microarrays, provides experimentally verified improvements in hybridization intensity and uniformity. Motion is coupled from a single motor to a sample holder via three suspension tethers. The microarrays may be immersed in a water bath during agitation to ...

02/09/06 - 20060030031 - Apparatus and method for measuring concentrations of molecules through a barrier
An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms and molecules that cause their chemical interactions and reactions, to infer, based on the behavior ...

02/09/06 - 20060030030 - Programmable mask and method of fabricating biomolecule array using the same
The present invention relates to a programmable mask used in a photolithography process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same and, more particularly, to a programmable mask which can increase a contrast ratio of transmittance versus shielding of light incident to ...

02/09/06 - 20060030029 - Analyte sensors
An analyte sensor with a tailored analyte binding motif that binds an analyte and a host protein operatively linked to the analyte binding motif, in which the binding of the analyte to the analyte binding motif produces a detectable change and manipulation of the analyte binding motif manipulates the responsiveness ...

02/09/06 - 20060030028 - Biosensor
A simple-structured biosensor is provided for measuring a substrate in a sample rapidly and highly precisely, without significant influence of a peptide included in the sample. A biosensor for measuring the substrate contained in a sample solution includes one or a plurality of insulating base plate(s) 1; a pair of ...

02/02/06 - 20060024815 - High sensitivity array-based detection system
A high sensitivity array-based detection system includes a plurality of probes immobilized onto a plurality of locations provided on a surface of a patterned array, such as a microarray. At least one target selectively binds to at least one of the plurality of probes when disposed proximate thereto under appropriate ...

02/02/06 - 20060024814 - Aptamer-functionalized electrochemical sensors and methods of fabricating and using the same
This disclosure describes systems for electrochemically sensing chemical species using nucleic acid aptamers and methods for using and fabricating these systems. This disclosure also describes a plurality of electrochemical sensors capable of measuring multiple chemical species. ...

01/26/06 - 20060019373 - Biosensor with rf signal transmission
A device (1) and method for measuring and or detecting the presence of biomolecules. The device comprises a resonance circuit arranged to operate and emit a resonance frequency (f). The resonance circuit comprises or is coupled to a sensor element (5) for detecting the binding of biomolecules (6a) to binding ...

01/26/06 - 20060019372 - Laser system
A laser system and interferometer are disclosed comprising a laser source for generating a laser beam, and first and second adjustable elements wherein the first and second adjustable elements have limited rotational motion so rotation of the first adjustable element causes deviation of a laser beam in one plane and ...

01/19/06 - 20060014271 - Fabrication of a completely polymeric microfluidic reactor for chemical synthesis
An inexpensive apparatus and method of fabricating completely polymeric (e.g., SU-8, PMMA, and PEEK) microfluidic reactors suitable for the synthesis of chemicals, particularly nanoparticles (e.g., mono, bi, tri, alloy, core-shell, polymeric, and metal-polymer nano-particles), is disclosed. A high precision process uses polymeric microfluidic patterning techniques and a new microfluidic sealing ...

01/19/06 - 20060014270 - System, device and method for detection of several individual analystes in a solution, and a disposible flow cell for use therein
A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing ...

01/12/06 - 20060008897 - Lens assembly for biological testing
The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having first and second surfaces formed on the lens, the second surface substantially opposed ...

01/12/06 - 20060008896 - Electronic analyte assaying device
The invention is an electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a LCD display. The ...

01/12/06 - 20060008895 - Microarray chip for detection of immunoglobulin
Disclosed is a microarray chip for allergy-related immunoglobulin detection, especially for quantitative detection of total IgE and allergen-specific immunoglobulins (such as specific IgE, specific IgG, and specific IgM), which comprises a solid substrate, a reactive layer fabricated on the solid substrate, and at least one allergen or substance capable of ...

01/05/06 - 20060003440 - Device and process unit for providing a hybridization chamber
A device provides a hybridization chamber for hybridizing nucleic acid samples, proteins or tissue sections on a slide, and is an essentially rectangular body movable opposite the slide. The device includes a surface, lines for supplying and/or removing media, a specimen supply line and an agitating device. The agitation device ...

01/05/06 - 20060003439 - Microfluidic system
The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. ...

01/05/06 - 20060003438 - Growth of inorganic thin films using self-assembled monolayers as nucleation sites
Systems and methods for preparing inorganic-organic interfaces using organo-transition metal complexes and self-assembled monolayers as organic surfaces. In one embodiment, a silicon wafer is cleaned and reacted with stabilized pirhana etch to provide an oxide surface. The surface is reacted with the trichlorosilyl end of alkyltrichlorosilanes to prepare self assembling ...

12/22/05 - 20050282267 - Micro device and method for high resolusion delivery and monitoring of stimuli to a biological object, in vitro
A micro device and method are provided for examining and testing a slice of a biological object, such as brain tissue. The micro device includes a body defining a chamber and a channel in communication with the chamber. A stimulation fluid flows axially along a flow path in the channel ...

12/08/05 - 20050272145 - Hand-held fluorescence polarimeter
A small, portable, hand-sized apparatus for detecting microorganisms or chemicals in liquid samples by fluorescence polarization. The apparatus operates using a low power excitation light source, such as an LED, in order to irradiate a sample with polarized light. Detection of emitted polarized light from the sample is detected in ...

12/08/05 - 20050272144 - Micro-reactor for improving efficiency of liquid mixing and reaction
A micro-reactor is provided with a flow jointing section to joint flows of at least two kinds of liquids including a reacting reagent by feeding the two kinds of liquids with a micro pump; a mixing flow path connected to a downstream end of the flow jointing section so as ...

12/08/05 - 20050272143 - Solid support comprising a functionalized electricity conductor or semiconductor surface, method for preparing same and uses thereof
The invention concerns a solid support comprising a functionalized electricity conductor or semiconductor surface coated with a functionalized electrografted organic layer wherein at least 90% of the number of functional groups of interest is accessible. The invention also concerns the method for preparing such a support and uses thereof, in ...

11/24/05 - 20050260741 - Wide field image for quantitative analysis of microarrays
This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges from about 30 degrees to about 75 degrees from the normal to ...

11/17/05 - 20050255582 - Surface modifying composition
R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that ...

11/17/05 - 20050255581 - Self-organized nanopore arrays with controlled symmetry and order
An ordered, single domain nanopore array having a macroscale area in a first material is provided. A method of making a nanopore arrays with a controlled pattern include providing a substrate comprising a first surface having a first patter, depositing a first material capable of forming nanopores onto said first-surface ...

11/10/05 - 20050250200 - Testing microreactor, testing device and testing method
A micro-reactor for analyzing a sample, comprises (1) a plate-shaped chip; (2) a plurality of regent storage sections each having a chamber to store respective agents; (3) a regent mixing section to mix plural regents fed from the plurality of regent storage sections so as to produce a mixed reagent; ...

11/10/05 - 20050250199 - Integrated nucleic acid diagnostic device
The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of ...

11/10/05 - 20050250198 - Biochemical measuring chip and measuring apparatus
A simple and convenient sensor and measuring apparatus utilizing the optical interference effect of an optical thin film capable of measuring the binding between biochemical substances at a high throughput and having alkali resistance. An optical thin film of silicon nitride is disposed on the first surface and the rear ...

11/03/05 - 20050244955 - Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays
Systems and methods are providing for performing high-throughput, programmable, multiplexed assays of biological, chemical or biochemical systems. Preferably, a micro-pallet includes a small flat surface designed for single adherent cells to plate, a cell plating region designed to protect the cells, and shaping designed to enable or improve flow-through operation. ...

11/03/05 - 20050244954 - Binding acceleration techniques for the detection of analytes
The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM. ...

11/03/05 - 20050244953 - Techniques for controlling the optical properties of assay devices
A system that employs optical detection techniques to identify the presence or quantity of an analyte residing in a test sample is provided. Unlike conventional systems, the optical detection system of the present invention uses the assay device itself to enhance the ability of an optical reader to detect the ...

11/03/05 - 20050244952 - Electroluminescent illumination source for optical detection systems
An optical detection system that utilizes an electroluminescent (EL) illumination source is provided. Unlike illumination sources used with some conventional optical detection systems, an EL device is relatively homogeneous and diffuse, and thus may provide uniform illumination to the test sample. In addition, the emitted light intensity of the EL ...

11/03/05 - 20050244951 - Array hybridization chamber with disassembly feature and method
The present invention provides an array hybridization apparatus including a gasket slide and an array slide. The array slide is adapted to be disposed closely adjacent the gasket slide to form a hybridization chamber for retaining an analyte solution in close proximity to an array. At least one of the ...

11/03/05 - 20050244950 - Method and apparatus of quantitative assays
A sample testing apparatus (100) for use in measuring an analyte in a sample (105) is disclosed. The apparatus includes a sample well (104) for receiving the sample. A solid analyte binding agent (160) is disposed in the sample well. The apparatus further includes a mixing device (156) for mixing ...

10/27/05 - 20050239194 - Biosensor
There is provided a biosensor in which a spacer 6 having a cutout portion is bonded between at least first support 1 and a second support 8 to form a specimen supply path 7 through which a supplied specimen is sucked into a space between the supports 1 and 8, ...

10/27/05 - 20050239193 - Device and method of use for detection and characterization of microorganisms and microparticles
The present invention includes a method and apparatus for the detection of a microorganism or microparticle. ...

10/20/05 - 20050233440 - Apparatus for biochemical analysis
An integrated device for nucleic acid analysis having a support and a first tank for introducing a raw biological specimen includes at least one pre-treatment channel, a buried amplification chamber, and a detection chamber carried by the support and in fluid connection with one another and with the tank. The ...

10/20/05 - 20050233439 - Optical method and system to determine distribution of lipid particles in a sample
The system and method of the present invention relate to characterizing lipoproteins in a sample. The system includes a light source that delivers electromagnetic energy in a predetermined range of wavelengths to the sample and a sensor that senses an intensity spectrum which emerges from the sample when the sample ...

10/20/05 - 20050233438 - Device based on partially oxidized porous silicon and method for its production
Device having a flat macroporous support material made of silicon and having surfaces, a plurality of pores each having a diameter in a range of from 500 nm to 100 μm distributed over at least one surface region of the support material and extending from one surface through to the ...

10/20/05 - 20050233437 - Integrated sample processing platform
An integrated desktop analytic device comprises a fluidics station coupled to a confocal microscope detector, and a biochip is moved from the fluidics station to the detector without manual intervention of an operator. ...

10/06/05 - 20050221473 - Sensor array integrated circuits
An apparatus includes a condensed array addressed device; and a spectroscope optically coupled to the condensed array addressed device. A method includes determining bonding and/or lack-of-bonding of a target molecule to a condensed array addressed device by characterizing a subsequent rate of electrolysis on the condensed array addressed device. A ...

09/29/05 - 20050214934 - Test cell for magnetic immunoreaction assay and method for producing same
A test cell for magnetic immunoreaction assay, comprising a polymer having a quantity of residual magnetism of 15 pT or less, when a magnetic field is applied under a magnetic field of 0.1 T, and with a distance between a sample and a SQUID sensor being set at 1.5 mm, ...

09/29/05 - 20050214933 - Ultrasonic micromixer with radiation perpendicular to mixing interface
The present invention provides an ultrasonic micromixer which is used in fields of bio-MEMS (micro-electro-mechanical-system) and μ-TAS (total analysis system) and radiates ultrasonic waves using a piezoelectric device in a direction perpendicular to a horizontal mixing interface between a plurality of sample fluids flowing in a chamber, so as to ...

09/29/05 - 20050214932 - Apparatus and chip for injecting substance into particle
An apparatus for injecting a substance into a particle includes a chip. The chip includes a base. A charging unit in which the particle is charged, an extracting unit from where the particle with the substance injected therein is extracted, a flow path that connects the charging unit to the ...

09/29/05 - 20050214931 - System and method for analyzing biochip
A system and method for analyzing a biochip are provided. Wherein, a first modulator circuit outputs a first modulated signal with a first frequency. A first light source module output a first light beam based on the first modulated signal. A first optical signal is generated after the first light ...

09/29/05 - 20050214930 - Apparatus and method for preventing cross contamination when dissassembling an array
An array hybridization apparatus and method. The apparatus employs a first substrate that contacts and attaches to an array slide, a second substrate that contacts and attaches to a gasket slide, and a separation means for separating the first substrate from the second substrate. Methods of disassembly of the apparatus ...

09/29/05 - 20050214929 - System for point of care diagnosis and/or analysis
This invention relates to a system (1) for point of care diagnosis and/or analysis of a body fluid of a patient, comprising at least one cartridge (2), at least one handheld diagnosis and/or analysis device (3) and at least one data processing device (4). Each cartridge (2) comprises a sample ...

09/22/05 - 20050208648 - Microdialysis needle assembly
A device for the measurement of analytes in a body fluid including a support with an upper surface, a layer adhered to the upper surface, the layer being of a hardenable material wherein at least one microfluidic channel has been etched after the layer is at least partially hardened, and ...

09/22/05 - 20050208647 - Biochemical concentrator and drug discovery
A novel label-free sensitive detection method by employing a novel sensitive charge sensor is provided. Dissociation constant information is provided by a simple measurement of the dissociation of the target molecule form the target's receptor. The later process is affected by a novel system and its configuration as described herein. ...

09/22/05 - 20050208646 - Bioarray chip reaction apparatus and its manufacture
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the ...

09/15/05 - 20050202556 - Process and spotting solution for preparing microarrays
A process is proposed for preparing a microarray including a multiplicity of analytical positions or spots and arranged on a support. The spots include probe molecules and a polymer which has been solidified to give a film. A spot is generated by applying an initially flowable spotting solution to the ...

09/15/05 - 20050202555 - Cell detection chip and fabricating method thereof and cell detecting method
A microarray detection chip is described. The detection chip includes several probes immobilized on a matrix, and these probes have affinity with corresponding specific molecules on a cell membrane surface. Since these probes are correlated with the specific molecules on the cell membrane surface, this microarray detection chip can be ...

09/15/05 - 20050202554 - Optical waveguide termination with vertical and horizontal mode shaping
An optical device is disclosed which includes a single-mode waveguide (700) which supports a first optical mode in a first region and a second optical mode in a second region. The waveguide includes a guiding layer (703) having at least one wing (750) extended outwardly from the guiding layer (703). ...

09/08/05 - 20050196856 - Polyelectrolyte-coated size-exclusion ion-exchange particles
A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided. ...

09/08/05 - 20050196855 - Cartridge for use with electrochemical sensor
A cartridge is disclosed. The cartridge includes an independent storage component and transport component. The storage component can be coupled with the transport component. The storage component includes one or more pockets that each contain a solution to be used in an assay. The transport component is configured to transport ...

08/25/05 - 20050186670 - Method of detecting error spot in dna chip and system using the method
Provided are a method of detecting an error spot and a system using the method. The method includes analyzing a difference in variances of a background intensity and a foreground intensity for each spot in a DNA chip, verifying whether the mean of the background intensity and the mean of ...

08/18/05 - 20050181498 - Multilayer body with a layer having at least one laser -sensitive material
The present invention relates to a multi-layer body which is a paper document with a hot stamping film embossed thereon. The hot stamping film has a laser-sensitive layer in which a laser-induced color image is produced by laser treatment. Arranged on the document are further security identifications such as a ...

08/11/05 - 20050176137 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
A bioreactor plug comprising a container having an outlet and an inlet and containing therein a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, the substrate supporting at least 5×106 stromal cells per cubic centimeter of ...

08/11/05 - 20050176136 - Afinity domain for analyte sensor
The preferred embodiments provide a membrane system, particularly for use on an electrochemical sensor, wherein the membrane system includes an affinity domain that dampens the effects of target interferant(s) on the sensor. The affinity domain can be layer, surface, region, and/or portion of the membrane system formed using sorbents ...

08/11/05 - 20050176135 - Cassette for isolation, amplification and identification of dna or protein and method of use
The present invention is directed to a device for DNA analysis. More particularly, the present invention is directed to a cassette which comprises a first chamber suitable for isolating DNA from a biological sample that is suspected of containing a target DNA, one or more second chambers suitable for amplifying ...

08/11/05 - 20050176134 - Apparatus and method to generate and control optical traps to manipulate small particles
The present invention relates generally to an apparatus and method to generate and control optical traps (1000, 1002) for manipulation of small particles. An upstream modification of an input laser beam (12, 22) provides a beam with a square or other preselected, cross section of intensity which can be used ...

08/04/05 - 20050170496 - Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method
A method for processing a nucleic acid sample contained in a liquid comprises: (a) introducing the liquid into a chamber (11) of a cartridge (12) which contains a chip shaped carrier (14), an active surface (15) of which carries an array of oligonucleotides; (b) positioning cartridge (12) into a cartridge ...

08/04/05 - 20050170495 - Lens assembly for biological testing
The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having a plurality of focusing lens segments greater than the plurality of biological samples ...

08/04/05 - 20050170494 - Structure, structure manufacturing method and sensor using the same
A plasmon resonance device 100 according to an example of a structure is characterized in that metallic particles 7 isolated from each other are formed in each of a plurality of pores 5 of anodic oxidized alumina 3. As a method of manufacturing the plasmon resonance device 100, a metal ...

08/04/05 - 20050170493 - Disposable sample processing module for detecting nucleic acids
A disposable sample processing module is provided for processing DNA or RNA samples. The module includes a hybridization chamber adapted to receive an oligonucleotide covalently bonded to an internal surface of the hybridization chamber. The module also include a sample well adapted to hold a DNA or RNA sample, said ...

07/28/05 - 20050164375 - Nucleic acid detection apparatus
A nucleic acid detection apparatus is described that include: a nucleic acid detection apparatus for amplifying a nucleic acid in a reaction solution accommodated in a detection container and detecting the amplified target nucleic acid, the nucleic acid detection apparatus including a plurality of detectors having a light-emitting part for ...

07/28/05 - 20050164374 - Method and apparatus for efficient thin film fluid processing of flat surfaces
A method and apparatus for thin film fluid processing of biological samples without rinsing between treatments is provided. An apparatus having a treatment zone for treating a biological sample with a liquid reagent, comprising first and second substrates having facing surfaces defining a space therebetween in which the biological sample ...

07/28/05 - 20050164373 - Diffusion-aided loading system for microfluidic devices
Microfluidic devices having a diffusion-aided system for loading samples into the microfluidic device are provided. Methods of gas-venting a microfluidic device through a non-porous, gas permeable material sealing cover layer, for example, during liquid sample loading, are also provided. The non-porous, gas-permeable material can be, for example, a polysiloxane, for ...

07/21/05 - 20050158850 - Biosensor
It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types ...

07/21/05 - 20050158849 - Process of fabricating polymer sustained microelectrodes
In one aspect, a process for fabricating a microelectrode is described that includes: a) providing a substrate comprising at least one polymer micro-ridge, where the polymer micro-ridge comprises an upper surface and two walls, and the two walls form an angle with a lower surface; b) depositing a metal thin ...

07/21/05 - 20050158848 - Method for immobolizing molecules on surfaces
In a method for immobilizing molecules on a surface, a layer of a hydrophobic, e.g., a non-swelling polymer, may be applied to the surface and molecules are immobilized on a surface of the polymer layer. The hydrophobic polymers may be polyimide or polystyrene, and the surface to which the polymer ...

07/21/05 - 20050158847 - Centrifugal array processing device
A device is provided in which a carousel is provided for use in such biochemical and chemical processes as polymerase chain reactions, using the centrifugal force resulting from rotation of the carousel to motivate fluid movement through microchannels embedded in microslides. The slides are arranged and positioned to function as ...

07/14/05 - 20050153435 - Multiple sample screening using a silicon substrate
A silicon substrate for enabling the analysis of a biological sample is provided which includes the silicon substrate having an active surface and a backside surface where the active surface of the silicon substrate has a plurality of recessed regions defined therein. The recessed region has a probe region on ...

07/14/05 - 20050153434 - Retaining microfluidic microcavity and other microfluidic structures
A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of ...

07/14/05 - 20050153433 - Retaining microfluidic microcavity and other microfluidic structures
A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of ...

07/14/05 - 20050153432 - Retaining microfluidic microcavity and other microfluidic structures
A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of ...

07/14/05 - 20050153431 - Retaining microfluidic microcavity and other microfluidic structures
A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of ...

07/14/05 - 20050153430 - Nucleic acid detecting cassette, nucleic and detecting apparatus utilizing nucleic acid detecting cassette, and nucleic acid detecting system utilizing nucleic acid detecting cassette
A nucleic acid detecting cassette comprises a fluid holding channel capable of varying the inner volume and holding a reagent, an inlet-outlet port connected to the fluid holding channel and capable of selecting an opened state under which the fluid injection out of the outer portion of the cassette can ...

07/14/05 - 20050153429 - Cell adhesion resisting surfaces
A coated surface that resists cell adhesion comprises hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins). ...

07/14/05 - 20050153428 - Measuring device and removal device for stored object
A measuring device (A) includes a cartridge mount portion (6), a take-out device (B) for taking out a sensor (S) from a cartridge (2), and a measurement circuit (31) for performing measurement by utilizing the sensor (S) taken out from the cartridge (2) by the take-out device (B). The take-out ...

07/07/05 - 20050148067 - Materials and methods for binding nucleic acids to surfaces
Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By masking the phosphate charges of the nucleic acids, undesired interactions may be minimized or eliminated, thereby ...

07/07/05 - 20050148066 - Apparatus and methods for parallel processing of micro-volume liquid reactions
Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays ...

07/07/05 - 20050148065 - Biosensor utilizing a resonator having a functionalized surface
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or ...

07/07/05 - 20050148064 - Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
A microfluidic device and method is disclosed for fractionating and/or trapping selected molecules with a diffusion barrier or porous membrane. The device includes a source fluid flow channel and a target fluid flow channel. The target fluid flow channel and the source fluid flow channel meet at cross-channel area and ...

07/07/05 - 20050148063 - Disposable reaction vessel with integrated optical elements
The present invention provides disposable, semi-reusable, or single use reaction vessels with integrated optical elements for use with diffraction based assay systems. The vessel for assaying liquids for analytes includes a housing having at least one chamber or well for receiving a liquid therein and an optical element integrally formed ...

06/23/05 - 20050136534 - Apparatus and method for dispensing fluid, semi-solid and solid samples
The invention relates generally to the field of automated collection and deposition of fluid, semi-solid, and solid samples of biological or chemical materials. More specifically, the invention relates to the field of microarrayers, which are devices for autonomously depositing minute droplets of biological or chemical fluid samples in ordered arrays ...

06/23/05 - 20050136533 - Biochip substrate holding method and biochip-reader
In measurement of a biochip whose substrate is held on a base and samples are spotted onto the sites in an array on the substrate, a biochip substrate holding method, which does not generate deviation of site positions between the arrangement of multiple samples on the biochip and mounting of ...

06/23/05 - 20050136532 - System of scattering surface plasmon resonance for detecting a target
A system of scattering surface plasmon resonance for detecting a target is disclosed. The system of scattering surface plasmon resonance includes: a base slide having a metal layer and a plurality of insulating nano-particles thereon, wherein said plurality of insulating nano-particles are dispersed on the surface of said metal layer ...

06/23/05 - 20050136531 - Folded substrate with applied chemistry
A chemical is applied to a substrate in discrete areas, and then the substrate is folded in such a manner as to cause the discrete chemical areas to become interior surfaces after folding to reduce or eliminate chemical residues when the exterior surfaces of the substrate contact other surfaces or ...

06/16/05 - 20050130296 - Electronic detection of biological molecules using thin layers
This invention provides novel sensors that facilitate the detection of essentially any analyte. In general, the biosensors of this invention utilize a binding agent (e.g. biomolecule) to specifically bind to one or more target analytes. In preferred embodiments, the biomolecules spans a gap between two electrodes. Binding of the target ...

06/16/05 - 20050130295 - Multifunctional self-diagnostic device for in-home health-checkup
A new kind of of multifunctional self-diagnostic device for in-home health-checkup is disclosed. Normal ranges for various test results are stored in the devices″s memory and users can easily tell whether their bio-chemical test response(s) fall within the normal range, and thus providing benefits of early in-home detection subclinical status, ...

06/16/05 - 20050130294 - Methods and apparatus for blood separation and analysis using membranes on an optical bio-disc
Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feature of a sample. The bio-disc also includes a conjugate release pad, and an analysis membrane ...

06/16/05 - 20050130293 - Dry reagent strip configuration, composition and method for multiple analyte determination
An assay device, analytical instrument and assay method for determining the presence or amount of an analyte in a fluid is disclosed. The device is a one-step lateral flow dry reagent immunoassay with one, two or more zones along a transverse axis of the device, each zone can contain or ...

06/09/05 - 20050124059 - Level-controlled pipette for automated analytic devices
An automatic pipette in an analytic device uses disposable pipette tips, and in which proper coupling of the pipette tip to the pipette, accurate volume of the aspirated fluid, and distance of the pipette tip to a biochip are determined using a plurality of sensors that are coupled to the ...

06/09/05 - 20050124058 - System for housing/processing carrier and method for housing/processing carrier
An object is to provide a carrier housing/processing apparatus and a method wherein complicated reaction processes are simplified, and the processes can be easily performed with a small scale apparatus structure. The construction comprises; one or a plurality of carriers fixed or able to be fixed with chemical substances such ...

06/02/05 - 20050118709 - High capacity assay platforms
A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of ...

06/02/05 - 20050118708 - Cover for a hybridization chamber
Cover of a hybridization chamber with a peripheral frame with filling and ventilation holes extending from the upper face to the lower face of the frame, a peripheral shoulder outside the filling and ventilation holes on the lower face of the frame, a cover wall arranged within the frame, flush ...

06/02/05 - 20050118707 - Positioning system for moving a selected station of a holding plate to a predetermined location for interaction with a probe
A device for positioning the tip of an elongated probe (14) at a selected station of a holding plate (12) includes motors to move the holding plate and a supporting stage within a coordinate plane (mxy). The elongated probe is also movable along a linear probe axis that is orientated ...

###

Design/code © 2013 FreshContext LLC/Freshpatents.com.
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and may contain additional data/images. FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents and there may be applicable trademarks or servicemarks within the documents.

FreshPatents.com Support - Terms & Conditions