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Chemistry: Molecular Biology And Microbiology > Enzyme (e.g., Ligases (6. ), Etc.), Proenzyme; Compositions Thereof; Process For Preparing, Activating, Inhibiting, Separating, Or Purifying Enzymes > Transferase Other Than Ribonuclease (2.) Transferase Other Than Ribonuclease (2.)Transferase Other Than Ribonuclease (2.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087426 - Novel transferase and amylase, process for producing the enzymes, use thereof, and gene coding for the same The invention provides a novel transferase that acts on a saccharide, as a substrate, composed of at least three sugar units wherein at least three glucose residues on the reducing end are linked α-1,4 so as to transfer the α-1,4 lingages to a α-1, α-1 linkages; a process for producing ... 03/01/07 - 20070048854 - Los locus from c. jejuni This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter ... 03/01/07 - 20070048853 - Carnitine palmitoyltransferase ii crystals The present invention provides crystals of carnitine palmitoyltransferase (CPT) and co-crystals of CPT with an inhibitor compounds that allow screening for novel inhibitors of CPT-2 by determining the structure of co-crystals based on the coordinates of the crystals disclosed herein. ... 11/30/06 - 20060270013 - Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways The invention relates to a method for the preparation of evolved microorganisms which permit a modification of metabolic pathways, comprising the following steps: a) production of a modified microorganism by genetic modification of initial microorganism cells such as to inhibit the production of or the consumption of a metabolite when ... 09/28/06 - 20060216808 - Hyaluronan synthase gene and uses thereof The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan ... 09/21/06 - 20060211102 - Human lysophosphatidic acid acyltransferase gamma-1 polypeptide Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase. ... 09/14/06 - 20060205053 - 27411, a novel human pgp synthase The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosis and treatment in PGP synthase-mediated or -related disorders. The invention further ... 08/24/06 - 20060188973 - 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 (papss1) sequence variants Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described. ... 08/24/06 - 20060188972 - Targeted modification of chromatin structure Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences. ... 08/17/06 - 20060183211 - Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C—C bond between a prenyl group and a compound containing an aromatic nucleus, and also ... 08/17/06 - 20060183210 - Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member ... 08/03/06 - 20060172404 - Methods of screening for compounds that inhibit the biosynthesis of gpi in malaria parasites The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of ... 05/18/06 - 20060105444 - O-fucosyltransferase The present invention describes the identification, purification, recombinant production and characterization of novel O-fucosyltransferase enzymes. ... 05/11/06 - 20060099699 - Udp-galactose:beta-n-acetyl-glucosamine beta-1,3-galactosyl transferases, beta-3gal-t5 A novel gene defining a novel enzyme in the UDP-D-galactose: β-N-acetylglucosamine/β-N-acetylgalactosamine β1,3galactosyltransferase family, termed β3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of β3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs ... 05/04/06 - 20060094100 - Structural models of carnitine acyltransferases and uses thereof The present invention relates to structural models of carnitine acyltransferases, and, in particular, to models of the reactive sites of these enzymes. It is based, at least in part, on the X-ray crystallographic structures of murine carnitine acetyltransferase (“mCRAT”), both in pure form and in complex with its substrates carnitine ... 04/20/06 - 20060084162 - Catalytic domains of beta(1,4)-galactosyltransferase i having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the immunogenicity of an antigen; and polypeptide stem regions that can be used to promote in vitro folding of polypeptides, such as the catalytic domain from ... 03/16/06 - 20060057698 - Nucleic acids and polypeptides involved in the production of cryptophycin The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins. ... 03/16/06 - 20060057697 - Chondroitin systhetase and nucleic acid coding for the enzyme A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity. ... 03/16/06 - 20060057696 - Sugar chain synthases The present invention provides O-glycan α2,8-sialyltransferase which has novel substrate specificity and substrate selectivity, and β-galactoside α2,6-sialyltransferase which has novel action and substrate specificity. The sialyltransferase of the present invention can be used as a medicament for suppression of cancer metastasis, prevention of virus infection, suppression of inflammatory response, or ... 02/23/06 - 20060040371 - Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme. ... 01/19/06 - 20060014262 - Beta1,3-galactosyltransferase and dna encoding the same The present invention provides a protein having δ1,3-galactosyltransferase activity, a DNA encoding the protein, a transformant comprising the DNA, a process for producing the protein using the transformant, and a process for producing a galactose-containing complex carbohydrate using the transformant. ... 01/05/06 - 20060003430 - Lysophosphatidic acit acetyltransferases An isolated nucleic acid fragment encoding an LPAAT isozyme is disclosed. Construction of a chimeric gene encoding all or a portion of the LPAAT isozyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the LPAAT isozyme in a transformed host ... 11/24/05 - 20050260729 - Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production ... 10/06/05 - 20050221459 - Geranylgeranyl transferase type i (ggtase-i) structure and uses thereof Protein geranylgeranyl transferase type I (GGTase-I), a Ca1a2X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred proteins, including many GTP-binding regulatory proteins (G proteins). The presently disclosed subject matter comprises a plurality of crystal structures of mammalian GGTase-I in complex with substrates ... 09/29/05 - 20050214918 - Novel purified polypeptides from streptococcus pneumoniae The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 07/28/05 - 20050164363 - Novel purified polypeptides from staphylococcus aureus The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 07/14/05 - 20050153413 - Type ii thioesterase from streptomyces coelicolor a3(2) and the coding sequence The invention concerns a biosynthesis of nonaramatic polyketide compounds. More particularly, the present invention relates to a isolated polynucleotide molecule, a nucleic acid vector comprising the molecule, and isolated polypeptide and uses thereof. A new, type II thioestrerase can be obtained as an application outcome of this invention. The enzyme ... 06/16/05 - 20050130284 - Diacylglycerol acyltransferase genes, proteins, and uses thereof The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes and proteins that exhibit both long-chain acyltransferase and acetyltransferase activity. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant ... ### FreshPatents.com Support |