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Chemistry: Molecular Biology And Microbiology > Micro-organism, Tissue Cell Culture Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition > Recombinant Dna Technique Included In Method Of Making A Protein Or Polypeptide > Lymphokines Or Monokines Lymphokines Or MonokinesLymphokines Or Monokines patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087414 - Uses of human zven proteins and polynucleotides The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides. ... 04/05/07 - 20070077627 - Murine zcytor17 ligand polypeptides and polynucleotides The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing ... 03/01/07 - 20070048840 - Human zven polynucleotides The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood ... 02/22/07 - 20070042471 - Homogeneous preparations of il-28 and il-29 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity ... 02/22/07 - 20070042470 - Homogeneous preparations of il-28 and il-29 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity ... 02/22/07 - 20070042469 - Homogeneous preparations of il-28 and il-29 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity ... 02/22/07 - 20070042468 - Interferon-like protein zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides. ... 02/01/07 - 20070026500 - Crystalline neutrokine-alpha protein, method of preparation thereof, and method of use thereof The invention relates to a Neutrokine-alpha protein in crystalline form, a method of preparing a Neutrokine-alpha protein in crystalline form, and methods of using a Neutrokine-alpha protein in crystalline form. In particular, the three-dimensional structure of a Neutrokine-alpha protein in crystalline form is used to design molecules that have biological ... 12/14/06 - 20060281151 - Globular adiponectin variants An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to ... 10/12/06 - 20060228781 - Synthetic gene coding for human granulocyte-colony stimulating factor for the expression in e.coli The invention relates to the synthetic gene coding for hG-CSF which enables expression in E. coli with an improved expression level of the recombinant hG-CSF regarding the total cellular proteins after expression. ... 10/05/06 - 20060223145 - Method for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris This invention relates to a process for expression of recombinant Interferon-alfa2b polypeptide in yeast cells and its method of purification and formulation. ... 08/17/06 - 20060183200 - Methods and means relating to protein variants A method of providing a subject polypeptide variant with improved stability compared with a parent subject polypeptide, employing translation and selection using an RNA expression system, wherein two or more stability selection pressures are applied simultaneously during translation, two or more stability selection pressures are applied simultaneously during selecting, or ... 08/17/06 - 20060183199 - Novel expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived ... 06/29/06 - 20060141579 - Cytokine zcytor17 ligand polynucleotides The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing ... 06/15/06 - 20060127985 - Cytokine designated 4-1bb ligand and human receptor that binds thereto Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the ... 05/25/06 - 20060110802 - Cytokine designated 4-1bb ligand and human receptor that binds thereto Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the ... 04/27/06 - 20060088917 - Il-17 homologous polypeptides and therapeutic uses thereof The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073573 - Chemotactic cytokine iii Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists ... 04/06/06 - 20060073572 - Cytokine structurally related to il-17 The cytokine ML-1 is a target for treating airway inflammation. Candidate therapeutic agents for treating airway inflammation can be screened for the ability to bind to an ML-1 protein or polynucleotide, from the ability to decrease functional properties of ML-1, or for the ability to decrease ML-1 gene expression. Pharmaceutical ... 03/30/06 - 20060068474 - Endothelial-monocyte activating polypeptide iii A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the ... 01/12/06 - 20060008882 - Antibodies to chemokine alpha-5 The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and ... 12/01/05 - 20050266531 - Compositions and methods for inhibiting liver stellate cell growth The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocytes as containing a death factor that induces apoptosis of activated liver stellate cells. This pro-apoptotic ... 11/17/05 - 20050255560 - Ztnf11, a tumor necrosis factor Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ... 11/03/05 - 20050244930 - Il-21 antagonists The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC50 that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of ... 10/20/05 - 20050233418 - Cytokine polypeptides This invention relates to TMEM7 and TMEM7-related cytokines and to new members of the human cytokine polypeptide family, to methods of making such polypeptides, to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to methods of using ... 10/06/05 - 20050221443 - Tumor necrosis factor super family agonists The invention relates to novel proteins with TNFSF agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders. ... 08/25/05 - 20050186663 - Cystine-knot fold protein This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of ... 07/21/05 - 20050158831 - Multimeric fusion proteins of tnf superfamily ligands A method for constructing stable bioactive fusion proteins of the difficult to express turn or necrosis factor superfamily (TNFSF), and particularly members CD40L (CD 154) and RANKL/TRANCE, with collectins, particularly pulmonary surfactant protein D (SPD) is described. Single trimers of these proteins lack the full stimulatory efficacy of the natural ... 07/14/05 - 20050153400 - Human gil-19/ae289 proteins and polynucleotides encoding same Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed. ... 06/09/05 - 20050124044 - Interleukin-21 analogs Isolated polynucleotides encoding mature interleukin-21, interleukin-21 analogs, polypeptides obtainable from the polynucleotides and uses are disclosed. ... 06/09/05 - 20050124043 - Chemokine-like factors (cklfs) with chemotactic and hematopoietic stimulating activities The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound ... 06/02/05 - 20050118683 - Method for producing a polypeptide Disclosed are methods of producing a cytokine antagonist polypeptide by co-expressing the cytokine antagonist polypeptide with a nucleic acid encoding a complexing polypeptide for the cytokine antagonist polypeptide. ... ### FreshPatents.com Support |