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Chemistry: Molecular Biology And Microbiology > Micro-organism, Tissue Cell Culture Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition > Recombinant Dna Technique Included In Method Of Making A Protein Or Polypeptide > Hormones And Fragments Thereof

Hormones And Fragments Thereof

Hormones And Fragments Thereof patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

01/18/07 - 20070015257 - Alpha-msh related compounds and methods of use
The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering ...

01/11/07 - 20070009995 - Prevention of incorporation of non-standard amino acids into protein
The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino acids. Various embodiments of the invention provide for the substantial elimination of the incorporation of non-standard amino acids into recombinant proteins by ...

10/19/06 - 20060234352 - Homogeneity and secretion of recombinant proteins in mammalian systems
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. Specifically, the present invention relates to a method ...

10/19/06 - 20060234351 - Yeast protein expression secretion system
This invention discloses novel prepro-insulin polypeptides. The polypeptides consist of an N-terminal region, derived from N-terminal regions of secretory proteins, and a downstream insulin polypeptide region. The N-terminal region directs the polypeptides efficiently into the secretory pathway of yeasts. Modifications at the N-terminal region, just adjacent to the insulin polypeptide ...

10/05/06 - 20060223144 - Method for mass production of human pollicle stimulating hormone
The present invention relates to a method for mass-production of human follicle stimulating hormone, more precisely, to an expression vector containing human follicle stimulating hormone gene, a transformant transfected with the expression vector and a method for mass-production of human follicle stimulating hormone by using the same. Human follicle stimulating ...

08/17/06 - 20060183198 - Methods for expression and purification of recombinant human growth hormone
The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process ...

08/17/06 - 20060183197 - Variant growth hormone molecules conjugated with macromolecules compounds
Conjugates exhibiting growth hormone (GH) activity and comprising at least one non-polypeptide moiety covalently attached to a GH polypeptide, the amino acid sequence of which differs from that of wildtype human GH in at least one introduced and at least one removed amino acid residue comprising an attachment group for ...

07/27/06 - 20060166328 - Igf-i fusion polypeptides and therapeutic uses thereof
A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 ...

06/29/06 - 20060141578 - Method of protein synthesis
The present invention relates to a method of protein synthesis and, more particularly, to a method of effective protein synthesis by regulating the expression of a protein in a host cell, wherein said host cell is transformed with an expression vector comprising a promoter as well as a DNA fragment ...

05/04/06 - 20060094083 - Probiotic microorganisms producing chimeric human growth hormone fused with fc fragment of human igg for oral delivery system and methods for producing them
Accordingly, the invention demonstrates that the chimeric protein for oral delivery system can be absorbed in intestine, and delivery of the chimeric protein by oral route using Lactobacillus has very excellent efficiency in vivo test in rats. Accordingly, the Lactobacillus of the present invention is an excellent deliverer of protein ...

04/06/06 - 20060073571 - Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin b-subunit and uses thereof
The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropin-β fusion protein, and antibodies which recognize part or all the domains of the fusion protein. Also ...

01/19/06 - 20060014253 - Lamprey gnrh-iii polypeptides and methods of making thereof
Lamprey GnRH-III polypeptides for the four species of fish lamprey are disclosed. Also disclosed is a procedure for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing such polypeptides for sterilizing fish. ...

01/12/06 - 20060008881 - Mammalian diabetes-mediating proteins
Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable ...

12/29/05 - 20050287643 - Protein binding miniature proteins and uses thereof
In certain aspects, the present invention provides miniature proteins resulted from a protein scaffold such as an avian pancreatic polypeptide that can be modified by substitution of at least one amino acid residue. In other aspects, the present invention provides diagnostic and therapeutic uses of these miniature proteins. ...

11/10/05 - 20050250185 - Ogh fusion polypeptides and therapeutic uses thereof
A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit α1 or α2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). In one embodiment, the fusion protein comprises hOGH-hFc-hα2 or hTSH-hFc-hα1. ...

11/10/05 - 20050250184 - Peptide hormones zalpha48 and zsig97
The present invention relates to polynucleotide and polypeptide molecules for zalpha48 and zsig97, two proteins that define a novel peptide hormone family. The DNA encoding the peptides and the encoded peptides are useful in treating disorders of the thyroid, prostate, neural dysfunction, immune dysfunction, diseases of the pancreas, adrenal gland, ...

10/27/05 - 20050239170 - Alpha-msh related compounds and methods of use
The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering ...

10/20/05 - 20050233417 - Growth hormone variations in humans and their uses
The present invention relates to naturally-occurring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed variants of GH1, selected from the group consisting of: ...

10/06/05 - 20050221442 - Bacterial host cell for the direct expression of peptides
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth ...

10/06/05 - 20050221441 - Segment of glycosylation-deficient hgf alpha-chain
The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has ...

09/08/05 - 20050196842 - Polypeptides sharing sequence identity with a fibroblast growth factor polypeptide and nucleic acids encoding the same
The present invention is directed to novel polypeptides having homology to the PR0533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, ...

09/01/05 - 20050191728 - Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between ...

08/25/05 - 20050186662 - Heterodimeric follicle stimulating hormone-fc (fsh-fc) fusion proteins for the treatment of infertility
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc receptor (FcRn) and a second polypeptide including a beta subunit of FSH (βFSH) linked directly or indirectly to an FcRn binding ...



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