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Chemistry: Molecular Biology And Microbiology > Micro-organism, Tissue Cell Culture Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition > Recombinant Dna Technique Included In Method Of Making A Protein Or Polypeptide Recombinant Dna Technique Included In Method Of Making A Protein Or PolypeptideRecombinant Dna Technique Included In Method Of Making A Protein Or Polypeptide patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087413 - Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins Methods and compositions for producing secreted soluble receptors and biologically active polypeptides in trimeric forms are disclosed. The process involves fusing the DNA template encoding a soluble receptor with a ligand binding domain or biologically active polypeptide to a DNA sequence encoding a C-propeptide of collagen, which is capable of ... 04/19/07 - 20070087412 - Metalloprotease-disintegrin adam23 (svph3-17) The invention is directed to purified and isolated novel SVPH3-13 or SVPH3-17 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ... 04/19/07 - 20070087411 - Monomeric self-associating fusion polypeptides and therapeutic uses thereof Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target ... 04/19/07 - 20070087410 - Microbially-expressed thermotolerant phytase for animal feed The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase. ... 04/19/07 - 20070087409 - Angiotensin peptide-carrier conjugates and uses thereof The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of ... 04/19/07 - 20070087408 - Regulation of toll-like receptors on stem cells The discovery of Toll-like receptors (TLRs) on the surface of hematopoietic cells provides new methods for the stimulation and differentiation of various classes of progenitor cells. TLR2 and TLR4 agonists (natural ligands, mimetics, antibodies) are particularly useful in these methods. The cells can be isolated and used for various purpose ... 04/19/07 - 20070087407 - Hepatitis c receptor protein cd81 The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such purposes. ... 04/19/07 - 20070087406 - Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same Isoforms of RAGE and pharmaceutical compositions containing RAGE isoforms are provided. Methods for identifying and preparing RAGE isoforms are provided. Also provided are methods of treatment with the RAGE isoforms. ... 04/19/07 - 20070087405 - Expression system for producing collagen A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems and methods for the expression of the DNA molecule are also provided. ... 04/12/07 - 20070082381 - Polypeptides of alicyclobacillus sp. The present invention relates to Isolated mature functional polypeptide which is at least 90% identical to and exhibits the same function of a corresponding secreted polypeptide obtainable from the bacterium Alicyclobacillus sp. deposited under accession number DSM 15716 are disclosed. ... 04/12/07 - 20070082380 - Nucleic acids encoding and methods of producing fusion proteins The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain substantially intact. The agents are transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems. In some embodiments the ... 04/12/07 - 20070082379 - Novel chimeric polypeptide and use thereof A chimeric polypeptide comprising a TNF neutralizer domain, an IL-1 receptor antagonist domain, and a dimerization domain, wherein the three domains are operably linked to each other. Within the scope of this invention are (i) nucleic acids encoding the polypeptide; (ii) expression vectors and host cells containing the nucleic acids; ... 04/05/07 - 20070077626 - Polypeptides sharing sequence identity with a fibroblast growth factor polypeptide and nucleic acids encoding the same The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, ... 04/05/07 - 20070077625 - Purification of polypeptides A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the broth or homogenate an effective amount of a solution of 6,9-diamino-2-ethoxyacridine lactate (ethacridine lactate) to precipitate host cell impurities under conditions ... 04/05/07 - 20070077624 - Recombinant production of mixtures of antibodies The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention ... 04/05/07 - 20070077623 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/05/07 - 20070077622 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 04/05/07 - 20070077621 - Production of cpd glycosylases Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the ... 04/05/07 - 20070077620 - Site specific incorporation of phosphoserine into polypeptides using phosphoseryl-trna synthetase Nucleic acids encoding genes with SepRS and tRNASep activity for site specific incorporation of phosphoserine into a protein or polypeptide and methods of use thereof are described. Typically, SepRS preferentially aminoacylates tRNASep with O-phosphoserine and the tRNASep recognizes at least one codon such as a stop codon. In a preferred ... 04/05/07 - 20070077619 - Secretion of proteins from yeasts The present invention relates to expression constructs encompassing the nucleic acid sequence coding for a shuttle peptide construct processable by yeast cells; to corresponding expression vectors comprising such constructs; to methods carried out with the aid thereof for recombinant preparation of target proteins; to hosts transformed therewith; to shuttle peptides ... 03/29/07 - 20070072270 - Polypeptide We disclose a PS4 variant polypeptide derivable from a parent polypeptide, the parent polypeptide having non-maltogenic exoamylase activity, which PS4 variant polypeptide comprises one or more of the following substitutions: G69P, A141P, G223A, A268P, G313P, S399P and G400P, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence ... 03/29/07 - 20070072269 - Ubiquitin-specific protease occurring in the brain and dna encoding the same A ubiquitin-specific protease occurring in the brain and a DNA encoding it, which are useful for research on the molecular mechanism of the neuroplasticity expression and so on. ... 03/29/07 - 20070072268 - Sulfotransferase and dna encoding the enzyme A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin ≧0.05 and a molecular weight as calculated from constituent ... 03/29/07 - 20070072267 - Transformant having galactose induction system and use thereof The present invention provides a transformant having a gene expression inducing system having better responsiveness. The transformant of the invention has a galactose induction system and retains a coding region having a galactose induction system and encoding an assisting protein assisting transcription activation by a protein having the Gal4 activity ... 03/29/07 - 20070072266 - Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains ... 03/29/07 - 20070072265 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 03/29/07 - 20070072264 - Recombinant chimeric acetylcholine receptors and their derivatives recognized by cd4 t cells of myasthenic patients for the treatment of myasthenia gravis The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which ... 03/29/07 - 20070072263 - Dna19355 polypeptide, a tumor necrosis factor homolog A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided. ... 03/29/07 - 20070072262 - Arg1, arg2, arg3, his1, his2, his5, his6 genes and methods for stable genetic integration Novel genes encoding P. pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5 and HIS6 are disclosed. A method for inactivating alternately at least two biosynthetic pathways in a methylotrophic yeast is provided. A method for producing and selecting yeast strains characterized as being capable of genetic stable integration of heterologous sequences ... 03/29/07 - 20070072261 - Nucleic acids encoding pak5 polypeptidesm and methods of use thereof The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of ... 03/29/07 - 20070072260 - C1q related protein This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from ... 03/29/07 - 20070072259 - Fluorescent protein An object of the present invention is to provide a novel fluorescent protein derived from favia favus. The present invention provides a fluorescent protein derived from favia favus having the following properties: (1) an excitation maximum wavelength is 507 nm; (2) a fluorescence maximum wavelength is 517 nm; (3) a ... 03/22/07 - 20070065917 - Endogenous and non-endogenous, constitutively activated human g protein-coupled receptions The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity. ... 03/22/07 - 20070065916 - Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-mgam-4d and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to the corresponding amides, and the amidase is useful for hydrolysis of amides to ... 03/22/07 - 20070065915 - Nucleic acid expressed in the hypothalamus or muscle tissue in obese animals An isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complementary to a sequence encoding a molecule or derivative or homologue thereof wherein said nucleic acid molecule is expressed in a larger amount in one or both hypothalamus tissue or muscle tissue of obese animals compared to lean ... 03/22/07 - 20070065914 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 03/22/07 - 20070065913 - Isolation of binding proteins with high affinity to ligands The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via “display-less” library screening. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in soluble form in the periplasmic space ... 03/22/07 - 20070065912 - Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) ... 03/22/07 - 20070065911 - Hepatitis c virus vaccine The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and antibodies derived there from. ... 03/22/07 - 20070065910 - Mutations for enhanced tyrosine production The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar nucleic acids and methods for utilizing cells expressing mutated CM/PDH to produce tyrosine. ... 03/22/07 - 20070065909 - Prokaryotically produced antibodies and uses thereof The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment. ... 03/22/07 - 20070065908 - Human cathelicidin antimicrobial peptides Provided are peptide and peptide consensus sequences, which inhibit bacterial growth and/or viral growth and mimic the activity of LL-37, CRAMP, and/or FALL-39. The peptides are useful as antimicrobials, ant-inflammatories and antiviral agents. ... 03/22/07 - 20070065907 - Process for the production of biological substances by perfusion culturing of suspended animal cells The invention relates to a process for the production of a biological substance by perfusion culturing of suspended animal cells in a serum free cell culture medium, wherein the biological substance is separated from the cells by filtration, characterized in that at least 0.001 w/w % nonionic surfactant is present ... 03/22/07 - 20070065906 - Process for producing heterologous protein in e. coli A heterologous protein free from an inducer and a method for producing said protein are provided. A method for producing a heterologous protein which comprises the step of optionally culturing at low temperature recombinant E. coli cells expressing a heterologous protein under control of a promoter capable of inducing expression ... 03/22/07 - 20070065905 - Process for expression and secretion of proteins by the non-conventional yeast zygosaccharomyces bailii Herein is disclosed a method for the production of proteins. The protein is expressed by a yeast belonging to the species Zygosaccharomyces bailii. The yeast secretes the protein produced into the culture medium from where it is isolated, thereby simplifying the isolation process. Preferably the yeast is cultivated in chemically ... 03/22/07 - 20070065904 - Recombinant expression vectors for functional nav1.9 sodium channels The present invention is drawn to the stable cloning and expression of Nav1.9 sodium channel at the mRNA and protein levels, production of sodium channel currents characteristic of native currents in dorsal root ganglion neurons and to cell lines transiently or stably expressing recombinant Nav1.9 sodium channel. ... 03/15/07 - 20070059800 - Novel peptide, novel adsorbent, adsorption unit and adsorption method The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an ... 03/15/07 - 20070059799 - Inducing cellular immune responses to hepatitis b virus using peptide and nucleic acid compositions This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection. ... 03/15/07 - 20070059798 - Polypeptides useful for molecular weight determinations The invention also provides a process for preparing a composition comprising: preparing a mixture of polypeptides, wherein each polypeptide in the mixture (a) is a copolymer of the amino acids L-alanine, L-glutamic acid, L-tyrosine and L-lysine, and (b) may be present in the form of a pharmaceutically acceptable salt; and ... 03/15/07 - 20070059797 - Upstream control elements of the proopiomelanocortin gene and their use The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice ... 03/15/07 - 20070059796 - Binding motif and methods of regulating cell function The present invention relates to a binding motif and methods of regulating cell function which methods target a single amino acid residue preferably a Tyr in a binding motif equivalent to a motif of the common beta chain (βc) of the GM-CSF/IL-3/IL-5 receptor. Preferably, the cell functions affect cell survival ... 03/15/07 - 20070059795 - Engineered zinc finger proteins for regulation of gene expression Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome. ... 03/15/07 - 20070059794 - Chaperonin-target protein complex, method of producing the same, method of stabilizing target protein, method of immobilizing target protein, method of analyzing the structure of target protein, sustained-release formulation, and method of producing antib The present invention provides a chaperonin-target protein complex and a method of producing the same, and a method of stabilizing the target protein, a method of immobilizing the target protein, a method of analyzing the structure of the target protein, a sustained-release formulation, and a method of producing an antibody ... 03/15/07 - 20070059793 - Nogo receptor binding protein The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof. ... 03/15/07 - 20070059792 - Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously ... 03/15/07 - 20070059791 - Preparation of vaccines using a photosensitizer and light Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but ... 03/08/07 - 20070054364 - Polypeptide variants The invention relates to the provision of oligomeric polypeptides (dimers, trimers etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal ... 03/08/07 - 20070054363 - 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or ... 03/08/07 - 20070054362 - Recombinant production of mixtures of antibodies The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention ... 03/08/07 - 20070054361 - Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... 03/08/07 - 20070054360 - Compositions and methods for modulating immune responses The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and ... 03/08/07 - 20070054359 - Rational chemical modification of adiponectin variants An adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin, wherein the adiponectin variant has at least one covalently attached non-peptide moiety at at least one position selected from the group consisting of: A108, Y109, S146, D179, E220, R221, and L224, relative to ... 03/08/07 - 20070054358 - Insertion sequence-free bacteria A bacteria lacking genomic and non-genomic IS elements is provided. The bacteria may be more stable and useful for the production of amino acids, polypeptides, nucleic acids and other products. ... 03/08/07 - 20070054357 - Identification of useful bacteriophage A method of identifying particular bacteriophage is provided. ... 03/08/07 - 20070054356 - Glycine-rich proteins, their coding genes and applications This invention relates to Glycine-rich protein (Glyrichin), as well as its coding gene and application, especially relates to the application for antibacterial purpose. The Glyrichin of the present invention are at least one selected from the following protein families: proteins having amino acid residues in Sequence 1, 3-14 in the ... 03/08/07 - 20070054355 - Cbl-b polypeptides, complexes and related methods The application provides novel complexes of Cbl-b polypeptides and Cbl-b-associated proteins. The application also provides methods and compositions for treating Cbl-b-associated diseases such as viral disorders. ... 03/08/07 - 20070054354 - E.coli host cells with modified phos/psts periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type copurify with said recombinant antibody. ... 03/08/07 - 20070054353 - Nuclear receptor transcriptional corepressor and uses thereof The present invention provides a novel class of transcriptional corepressor polypeptides having an amino acid sequence which comprises at least one LXXLL nuclear receptor interacting NR box motif wherein L is leucine and X is any amino acid residue, and which are operably interactable with a nuclear receptor to actively ... 03/01/07 - 20070048839 - Novel amylolytic enzyme extracted from bacillus sp. a 7-7 (dsm 12368) and washing and cleaning agents containing this novel amylolytic enzyme The invention relates to a novel amylolytic enzyme extracted from the micro-organism Bacillus sp. A 7-7 (DSM 12368), to sufficiently similar proteins having an amylolytic function, to methods for the production thereof and to diverse fields of application for these proteins. In addition, they can be further developed beyond the ... 03/01/07 - 20070048838 - Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an ... 03/01/07 - 20070048837 - Site specific protein modification Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid ... 03/01/07 - 20070048836 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form ... 03/01/07 - 20070048835 - Cytokine receptor zcytor17 multimers Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and ... 03/01/07 - 20070048834 - Cytokine receptor zcytor17 multimers Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and ... 03/01/07 - 20070048833 - Cytokine receptor zcytor17 multimers Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and ... 03/01/07 - 20070048832 - Cytokine receptor zcytor17 multimers Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and ... 03/01/07 - 20070048831 - Cytokine receptor zcytor17 multimers Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and ... 03/01/07 - 20070048830 - Growth factor homolog zvegf4 Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the ... 03/01/07 - 20070048829 - Growth factor homolog zvegf4 Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the ... 03/01/07 - 20070048828 - Materials and methods for preparing dimeric growth factors Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a ... 03/01/07 - 20070048827 - Mammalian transforming growth factor beta-9 Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies. ... 03/01/07 - 20070048826 - Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes ... 03/01/07 - 20070048825 - Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... 03/01/07 - 20070048824 - Interleukin-17 receptor homologue Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.” ... 03/01/07 - 20070048823 - Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria The present disclosure relates to compositions and methods for producing recombinant apolipoproteins in lactic acid bacteria. ... 03/01/07 - 20070048822 - Erbb4 receptor-specific neuregulin related ligands and uses therefor The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, ... 03/01/07 - 20070048821 - Canine influenza vaccines The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza. ... 03/01/07 - 20070048820 - Methods for assaying inhibition of hiv-1 envelope glycoprotein-mediated membrane fusion This invention provides: agents determined to be capable of specifically inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4+ cell, but not a T cell-tropic isolate of HIV-1 to a CD4+ cell; and agents determined to be capable of specifically inhibiting the fusion of a T ... 03/01/07 - 20070048819 - Canine influenza vaccines The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza. ... 03/01/07 - 20070048818 - Human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 02/22/07 - 20070042467 - Nima interacting proteins A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or ... 02/22/07 - 20070042466 - Il-1 related polypeptides The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous ... 02/22/07 - 20070042465 - Mammalian transforming growth factor beta-9 Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies. ... 02/22/07 - 20070042464 - Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5′ upstream from a myeloproliferative sarcoma virus (MPSV) promoter. ... 02/22/07 - 20070042463 - Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or ... 02/22/07 - 20070042462 - Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb Prior art teaches an effective packaging capacity for adeno-associated virus and adeno-associated viral vectors of 4.1 kb to 4.9 kb as well as a packaging limit of 5.2 kb to 5.6 kb. However, the inventor discovered that this packaging limit as well as that effective packaging capacity does not apply ... 02/22/07 - 20070042461 - Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing ... 02/22/07 - 20070042460 - Oxidation of peptides The folding/oxidation of a reduced peptide or partially reduced peptide to form a disulphide bridged peptide is effected by dissolving it in an oxidizing organic solvent, alone or in admixture with water, adding an aqueous alkaline buffer to the solution, and recovering the resultant disulphide bridged peptide. The preferred oxidizing ... 02/15/07 - 20070037256 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/15/07 - 20070037255 - Antibody variants with faster antigen association rates Antibody variants with faster antigen association rates are disclosed. The antibody variants have one or more amino acid alteration(s) in or adjacent to at least one hypervariable region thereof which increase charge complementarity between the antibody variant and an antigen to which it binds. ... 02/15/07 - 20070037254 - Expression vectors and methods Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage. ... 02/15/07 - 20070037253 - Methods and compositions for treatment of arthritis and cancer The present invention provides a new 18-residue homodimerized peptide, designated PIP [59-67] dimer (SEQ ID NO: 1), which is a mutant of the optimized anti-inflammatory peptide P-NT.II, the patent for which has recently been filed [1]. P-NT.II has the potential to modulate both the inflammatory and bone damaging components of ... 02/15/07 - 20070037252 - Compositions and methods for topical application and transdermal delivery of an oligopeptide The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged “backbone” having positively charged branching or “efficiency” groups, as described herein. Most preferably ... 02/15/07 - 20070037251 - Novel protein expression system The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for efficient removal of purification tags. The invention further provides expression systems and a methods for purifying and isolating proteins. ... 02/15/07 - 20070037250 - Method for obtaining precursor z and use thereof for the production of a means for therapy of human molybdenum cofactor deficiency The invention relates to a method for obtaining the molybdopterin derivative precursor Z, wherein an over-production of precursor Z occurs in host organisms by recombinant expression of precursor Z synthesizing proteins. The invention further relates to the use of precursor Z for the production of a means for the therapy ... 02/15/07 - 20070037249 - Molecules that block viral infectivity and methods of use thereof Embodiments relate to the discovery that certain tripeptide amides and glycine amide can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More specifically, medicaments comprising said tripeptide amides and/or glycine amide and methods of using said compounds for the prevention and treatment of viral infection, such ... 02/15/07 - 20070037248 - Production of modified glycoproteins having multiple antennary structures The present invention relates to eukaryotic host cells, especially lower eukaryotic host cells, having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar and sugar nucleotide transporters to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an ... 02/15/07 - 20070037247 - Thermostable ribonuclease h A polypeptide having an RNaseH activity and being highly useful in gene engineering; a gene encoding. this polypeptide; and a genetic engineering process for producing the polypeptide. ... 02/15/07 - 20070037246 - Methods and compositions for enhanced protein expression and purification Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed. ... 02/08/07 - 20070031936 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/08/07 - 20070031935 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/08/07 - 20070031934 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/08/07 - 20070031933 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/08/07 - 20070031932 - Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant ... 02/08/07 - 20070031931 - Biosynthetic binding proteins for immuno-targeting Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains two polypeptide chains, each of which define single-chain Fv (sFv) binding ... 02/08/07 - 20070031930 - Process for protein extraction The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released ... 02/08/07 - 20070031929 - Polypeptides homologous to vegf and bmp1 The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be ... 02/08/07 - 20070031928 - Glucoamylase variants The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. ... 02/08/07 - 20070031927 - Biological system and assay for identifying inhibitors of tubulin glutamylases Tetrahymena is used as a host cell in a biological assay for identification of inhibitors of tubulin glutamylases. ... 02/08/07 - 20070031926 - Refolded membrane protein in monodisperse form The present invention relates to a method for preparing a solution of a refolded, recombinantly expressed or chemically synthesized eukaryotic membrane protein in monodisperse form, to methods for preparing a crystalline form of a recombinantly expressed or chemically synthesized membrane protein, to a crystalline form of a recombinantly expressed, or ... 02/08/07 - 20070031925 - Small molecular weight tnf receptor multimeric molecule The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more polypeptide linkers. The receptor can further comprise a signal peptide of a secreted protein, such as the ... 02/08/07 - 20070031924 - Biomolecule partition motifs and uses thereof The invention provides amino acid sequence motifs (e.g., biomolecule partition motifs) that can direct targeting of intracellular polypeptides to and through membranes, including cell surface membranes. ... 02/08/07 - 20070031923 - Modified viral particles with immunogenic properties and reduced lipid content useful for treating and preventing infectious diseases Described is a composition and method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating immunogenic ... 02/08/07 - 20070031922 - Altered polypeptides with increased half-life Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life. ... 02/08/07 - 20070031921 - Potent combinations of mrna transport elements This invention provides expression vectors that comprise a combination of RNA transport elements that improve expression. ... 02/08/07 - 20070031920 - High expression locus vector based on ferritin heavy chain gene locus High expression locus vectors based, in part, on the ferritin heavy chain locus are disclosed. The vectors include distal 5′ flanking sequences and/or proximal 5′ regulatory sequences derived from ferritin heavy chain locus. The vectors include a site for insertion of heterologous sequences and proximal 3′ regulatory and distal 3+ ... 02/01/07 - 20070026499 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/01/07 - 20070026498 - Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, ... 02/01/07 - 20070026497 - Method for controlling metallophosphate precipitation in high cell density fermentations The invention relates to the use of a phosphate glass as a phosphorous source in the media of high cell density bacterial fermentation processes in order to reduce metallophosphate precipitation reactions. The methods of the invention demonstrate a practical method for controlling levels of metallophosphate precipitation in both the nutrient ... 02/01/07 - 20070026496 - Process for producing polypeptides A process is described for producing a polypeptide heterologous to E. coli wherein E. coli cells comprising nucleic acid encoding the polypeptide are cultured in a culture medium while feeding to the culture medium a transportable organophosphate, such that the nucleic acid is expressed. The polypeptide is then recovered from ... 02/01/07 - 20070026495 - Novel integrin ligand itgl-tsp ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retmopathy), restenosis, ... 02/01/07 - 20070026494 - Mammalian iap gene family, primers, probes and detection methods Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. ... 02/01/07 - 20070026493 - System and method for optimizing animal production using genotype information A system for generating optimized values for variable inputs to an animal production system. The system includes a simulator engine configured to receive a plurality of animal information inputs and generate a performance projection. At least one of the animal information inputs is designated as a variable input and at ... 02/01/07 - 20070026492 - Expression of g protein-coupled receptors with altered ligand binding and/or coupling properties Modified forms of G protein-coupled receptors which display altered ligand binding and/or coupling properties are provided as well as cells expressing such receptors and assays utilizing these cells for screening and identifying pharmaceutically effective compounds that specifically modulate the activity of a these modified forms of G protein coupled receptors. ... 02/01/07 - 20070026491 - Candida kefyr cytosine deaminase A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme. ... 02/01/07 - 20070026489 - Vegetarian protein a preparation and methods thereof The invention relates to methods of producing Protein A without contamination of the Protein A by animal products. The invention also relates to a vegetarian fermentation media in which Staphylococcus aureus is grown to produce a vegetarian Protein A. The invention further relates to a vegetarian Protein A and the ... 02/01/07 - 20070026488 - Biosynthesis of bryostatins by polyketide synthases (pks) The present invention relates to the discovery, isolation and sequencing of novel polyketide synthase genes. These newly identified genes are involved in the biosynthesis of bryostatins. The genes are found to be expressed in all life stages of Bugula neritina, are associated with the bacterial symbiont Endobugula sertula and are ... 02/01/07 - 20070026487 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of ... 02/01/07 - 20070026486 - Coumermycin/novobiocin-regulated gene expression system A chimeric transactivator comprises a transcription activation domain, a repressor protein DNA binding domain and the bacterial DNA gyrase B subunit. A target gene is operatively linked to operator DNA sequences recognized by the repressor binding domain. The addition of the antibiotic coumermycin results in a coumermycin-switched dimerization of the ... 01/25/07 - 20070020732 - Mast cell-specific signal transducer and cdna thereof The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression ... 01/25/07 - 20070020731 - Thermostable amylase polypeptides, nucliec acids encoding those polypeptides and uses thereof This is invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability. ... 01/25/07 - 20070020730 - Method for overexpression of zwitterionic polysaccharides The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular ... 01/25/07 - 20070020729 - Novel collectin Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human ... 01/25/07 - 20070020728 - Muteins of apolipoprotein d A method of generating a mutein of human apolipoprotein D having detectable binding affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of subjecting apolipoprotein D to mutagenesis at the sequence positions 34 to 38, 60, 62 to 66, 68, 89 to 93, 115, ... 01/25/07 - 20070020727 - Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity. ... 01/25/07 - 20070020726 - Novel glutaminase, its gene and a method of producing it Glutaminase is purified from an Aspergillus oryzae, its partial amino acid sequence is determined, a partial sequence of glutaminase gene is obtained by PCR based on the obtained information, and DNA fragments containing glutaminase gene from Aspergillus oryzae genomic library and cDNA library, and Aspergillus nidulans genomic library by hybridization ... 01/25/07 - 20070020725 - Prokaryotically produced antibodies and uses thereof The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment. ... 01/25/07 - 20070020724 - 94 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 01/25/07 - 20070020723 - Ceramide kinase-like proteins A ceramide kinase like protein encoded by a polynucleotide of SEQ ID NO: 1 to SEQ ID NO: 9 and its use. ... 01/25/07 - 20070020722 - Telomere elongation The present invention relates, in general, to telomeres, and, in particular, to a method or effecting telomere elongation in mammalian cells. The invention further relates to a protein suitable for use in such a method and to nucleic acid sequences encoding same. ... 01/18/07 - 20070015254 - Crystal harvest from fermentation broth A method for producing a crystalline and/or amorphous metabolite suspension from a fermentation broth comprising treating the fermentation broth with one or more coagulants and/or one or more flocculants; and separating the biomass of the fermentation broth from the coagulated and/or flocculated fermentation broth by use of a separation equipment, ... 01/18/07 - 20070015253 - Latent fusion protein The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically ... 01/18/07 - 20070015252 - Corynebacterium glutamicum genes encoding regulatory proteins Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 01/18/07 - 20070015251 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 01/18/07 - 20070015250 - Methods and compositions for increasing longevity and protein yield from a cell culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, ... 01/18/07 - 20070015249 - Chondroitin polymerase and dna encoding the same A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase. ... 01/18/07 - 20070015248 - Expression vector and use thereof The present invention relates to an expression vector for the use in an auxotrophic, prokaryotic host cell and relates to an expression system containing an expression vector and an auxotrophic, prokaryotic host cell. The invention furthermore relates to an antibiotic-free fermentation medium containing an expression vector as mentioned above as ... 01/18/07 - 20070015247 - Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind. ... 01/18/07 - 20070015246 - Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer. ... 01/18/07 - 20070015245 - Production of a highly active, soluble form of the cytochrome p450 reductase (cpr a) from candida tropicalis The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal region. Also provided are host cells comprising the subject soluble CPR proteins. In addition, the present invention provides nucleotide and corresponding amino acid sequences ... 01/18/07 - 20070015244 - System for antibody expression and assembly The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can ... 01/18/07 - 20070015243 - Chimeric empty viral-like particles derived from the infectious bursal disease virus (ibdv), process for their production and applications The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound ... 01/18/07 - 20070015242 - Neostatins The invention provides fragments of type XVIII collagen termed neostatins, and methods for their use in the treatment of ophthalmological disorders associated with angiogenesis. ... 01/18/07 - 20070015241 - Sulfur atom-free enzyme protein A sulfur atom-free enzyme protein retaining the activity of the original enzyme protein and having oxidation resistance wherein L-cystein and L-methionine residues of the enzyme protein are substituted with 18 types of L-amino acid residues: L-alanine; L-aspartic acid; L-glutamic acid; L-phenylalanine; L-glycine; L-histidine; L-isoleucine; L-lysine; L-leucine; L-asparagine; L-proline; L-glutamine; L-arginine; ... 01/18/07 - 20070015240 - Subtilases The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase. ... 01/18/07 - 20070015239 - Correlation between the fucose content/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity The present invention relates to monoclonal antibodies with high ADCC activity, characterised in having glycannic structures with a ratio (fucose content/galactose content) of 0.6 or less on the glycosylation site thereof in the Fc region. The invention also relates to pharmaceutical compositions, containing said monoclonal antibodies with high effector activity. ... 01/18/07 - 20070015238 - Production of pseudotyped recombinant aav virions Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012−1×1013 vector genomes/ml. ... 01/11/07 - 20070009992 - Variant tlr4 nucleic acid and uses thereof The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality. ... 01/11/07 - 20070009991 - Gene expression in transgenic avians A recombinant nucleic acid is provided having an avian promoter. One embodiment of the present invention contemplates the use of a gut-specific promoter, wherein a promoter can be the chicken intestinal fatty acid binding protein promoter region. A method for making a transgenic bird is also disclosed by transfecting a ... 01/11/07 - 20070009990 - Site-specific incorporation of redox active amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active ... 01/11/07 - 20070009989 - Synthetic heparanase molecules and uses thereof The present invention relates to synthetically produced, enzymatically active heparanase nucleic acid molecules that are capable of expression in high yield heterologous expression systems, and to polypeptides encoded by said molecules. Also provided herein are methods of expressing mammalian heparanase in heterologous expression systems, wherein high yields of biologically active ... 01/11/07 - 20070009988 - Novel fungal proteins and nucleic acids encoding same Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein ... 01/11/07 - 20070009987 - Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same The present invention relates to a method producing dimer of chimeric recombinant binding domain-heterogeneous functional group fusion([B-F fusion]2) by using covalent disulfide-bond-bridge connecting the two monomers of chimeric recombinant binding domain-heterogeneous functional group fusion(B-F fusion). The dimer of chimeric recombinant binding domain(B)-heterogeneous functional group(F) fusion was the first to be ... 01/11/07 - 20070009986 - Compositions for modulating immune cell activity and methods for detection thereof The invention relates to a new method for measuring cytotoxic activity of immune cells, and to methods and products for treating abnormal immune responses. ... 01/11/07 - 20070009985 - Novel nitrile hydratase The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified ... 01/04/07 - 20070004008 - Human ccv polypeptides The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 01/04/07 - 20070004007 - Tnf-alpha converting enzyme inhibitory agents and stimulatory agents The invention provides peptides, variants of peptides, peptide fragments, and peptidomimetics that can inhibit the protease activity of tumor necrosis factor alpha converting enzyme. The invention also provides coupled proteins containing a partner protein coupled to a peptide, peptide fragment, or peptidomimetic. The invention also provides polyproteins containing at least ... 01/04/07 - 20070004006 - Method and kit for detecting porcine reproductive and respiratory syndrome virus The invention provides methods, devices, and kits for the detection of a class of porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV, in a biological fluid. The invention is based in part on an agent which binds the nucleocapsid (N) protein of PRRSV. The agent may be an antibody ... 01/04/07 - 20070004005 - Tendon-inducing compositions Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair. ... 01/04/07 - 20070004004 - Process for producing recombinant protein in bacterium belonging to the genus rhodococcus Provided is an expression vector capable of constitutive expression of a foreign gene in a bacterium belonging to the genus Rhodococcus. The vector is a constitutive expression vector for a bacterium belonging to the genus Rhodococcus comprising: DNA comprising a nucleotide sequence of a mutated TipA gene promoter where a ... 01/04/07 - 20070004003 - Koji mold-origin phospholipase a2 It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived ... 01/04/07 - 20070004002 - Artificial mammalian chromosome It is intended to provide an artificial mammalian chromosome which is stably held in mammalian cells and allows efficient expression of a target gene carried thereby. Namely, a first cyclic vector containing a mammalian centromere sequence and a selection marker gene and a second cyclic vector containing a functional sequence ... 12/28/06 - 20060292672 - Cell lines for expressing enzyme useful in the preparation of amidated products Cell lines are provided for expressing peptidylglycine alpha-amidating monooxygenase (PAM), or one of its two catalytic domains. High levels of enzyme expression are achieved while utilizing a non-animal source, low protein tissue culture medium. A robust two-step downstream purification results in high enzyme purity. Resulting PAM, or its PHM catalytic ... 12/28/06 - 20060292671 - Mannitol induced promoter systems in bacterial host cells The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention ... 12/28/06 - 20060292670 - Nell peptide expression systems and bone formation activity of nell peptide The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides. ... 12/28/06 - 20060292669 - Mammalian prickle gene The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be ... 12/28/06 - 20060292668 - Nuclear factor of activated t cell receptor Novel nuclear factor of activated T cells (“NFAT”) activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The ... 12/21/06 - 20060286640 - Process for production of polypeptides Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous ... 12/21/06 - 20060286639 - Complementary dnas encoding proteins with signal peptides The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs ... 12/21/06 - 20060286638 - Cell lines The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins. ... 12/21/06 - 20060286637 - Production of sialylated n-glycans in lower eukaryotes The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic ... 12/21/06 - 20060286636 - Vegf variants Applicants have defined the pro-inflammatory domain of the Vascular Endothelial Growth Factor VEGF164(165) protein molecule using VEGF164 protein mutants in which the heparin binding domain is inactivated through alanine scanning, site directed mutagenesis. The invention provides novel VEGF variants having a modified heparin binding domain. The VEGF variants modified heparin ... 12/21/06 - 20060286635 - Albumin fusion proteins The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention ... 12/21/06 - 20060286634 - Vector A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor. ... 12/21/06 - 20060286633 - Methods for production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a ... 12/21/06 - 20060286632 - Cysteine-containing peptides having antioxidant properties Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related ... 12/21/06 - 20060286631 - Method for preparating t-20 peptide by high cell density cultivation of recombinant e. coli containing t-20 peptide coding gene The present invention relates to a method for preparing a T-20 peptide by the high-cell-density cultivation of recombinant E. coli containing a T-20 peptide-coding gene, as well as a method for isolating and purifying the T-20 peptide with high purity from E. coli where the T-20 peptide have been expressed. ... 12/21/06 - 20060286630 - Posh interacting proteins and related methods The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as viral disorders, cancer, and neurological disorders. ... 12/14/06 - 20060281150 - Preparing membrane receptors from extracellular baculoviruses A method of determining whether a membrane receptor expressed in recombinant extracellular baculoviruses is active, the method comprising: providing recombinant extracellular baculoviruses expressing a membrane receptor; contacting the extracellular baculoviruses with a ligand to the membrane receptor; and determining whether binding of the ligand to the receptor occurs, wherein said ... 12/14/06 - 20060281149 - Transforming growth factor-beta-related molecules and uses thereof The present invention provides Transforming Growth Factor-Beta-Related (TGF-β-R) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TGF-β-R polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, ... 12/14/06 - 20060281148 - Cell-free extracts and synthesis of active hydrogenase Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains expressing at least one hydrogenase accessory protein. In some embodiments, the extracts are produced under anerobic conditions. ... 12/14/06 - 20060281147 - Thrombin-like recombinant baxtroxobin expressed by pichia sp.and production method thereof A recombinant thrombin-like enzyme batroxobin expressed by yeast, a production method thereof, and use of the batroxobin as a hemostatic agent or antithrombotic agent is disclosed. In order to express recombinant thrombin-like enzyme, an expression vector is prepared by inserting cDNA encoding the enzyme, the transformed cell is prepared by ... 12/14/06 - 20060281146 - Novel compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... 12/07/06 - 20060275872 - Method for modifying transglutaminases from microorganisms The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying MTG on the basis of the three-dimensional structure, and ... 12/07/06 - 20060275871 - Dna encoding mammalian phosphodiesterases The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such ... 12/07/06 - 20060275870 - Novel g-protein coupled receptors and uses therefor Novel G-protein coupled receptor molecules, designated LGR6 polypeptides, proteins, and nucleic acid molecules, are disclosed. In addition to isolated, LGR6 proteins, the invention further provides isolated LGR6 fusion proteins, antigenic peptides and anti-LGR6 antibodies. The invention also provides LGR6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule ... 12/07/06 - 20060275869 - Novel matrix metalloproteinases The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing. ... 12/07/06 - 20060275868 - Fusion proteins comprising tumor necrosis factor receptor Fusion proteins having a tumor necrosis factor receptor (TNF-R) polypeptide and at least one additional polypeptide covalently fused thereto and selected from an interleukin-1 receptor (IL-1R) and a second TNF-R polypeptide. The receptor polypeptides are preferably fused together by a peptidyl linker. Suitable fusions include, for example, TNF-R-linker-TNF-R; TNF-R-linker-IL-1R; and ... 12/07/06 - 20060275867 - Process A process for cultivating animal cells producing complex proteins, wherein one plant-derived peptone or a combination of plant-derived peptones is fed to the cell culture, as well as a method for reducing the toxic effect of over-feeding amino acids during a fed-batch process for cultivating animal cells producing complex proteins. ... 12/07/06 - 20060275866 - Novel nucleic acid sequences encoding g-protein coupled receptors The invention provides isolated nucleic acids molecules, designated 2871, 14926, 44576, 23992, 1983, 52881, 2398, and 52872 nucleic acid molecules, which encode novel G protein-coupled receptor family members that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2871, 14926, 44576, 23992, 1983, 52881, ... 12/07/06 - 20060275865 - Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy The present invention relates, in general, to autotaxin. In particular, the present invention relates to a DNA segment encoding autotaxin; recombinant DNA molecules containing the DNA segment; cells containing the recombinant DNA molecule; a method of producing autotaxin; antibodies to autotaxin; and identification of functional domains in autotaxin. ... 12/07/06 - 20060275864 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 11/30/06 - 20060269999 - Promoters Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS:1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in gram positive bacteria. ... 11/30/06 - 20060269998 - Methods and compositions to modulate adhesion and stress tolerance in bacteria Methods and compositions are provided which improve the adhesion of a bacteria to target substrates and/or improve the stress tolerance of a bacteria. Methods comprise exposing bacteria to adhesion adaptive conditions and thereby increasing the adhesion activity and/or stress tolerance of the bacteria. Further provided are bacteria having a modulated ... 11/30/06 - 20060269997 - Vascular endothelial cell growth factor variants and uses thereof The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided. ... 11/30/06 - 20060269996 - Human voltage gated sodium channel beta1a subunit and methods of use DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In ... 11/30/06 - 20060269995 - Novel assays utilizing nicotinic acetylcholine receptor subunits The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto. ... 11/30/06 - 20060269994 - Non-ribosomal peptide synthetases and associated biosynthetic genes The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes. ... 11/30/06 - 20060269993 - Dnaxccr10 Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided. ... 11/30/06 - 20060269992 - Methods of production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a ... 11/30/06 - 20060269991 - T cell protein and nucleotides encoding the same The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including ... 11/30/06 - 20060269990 - Process for the preparation of recombinant polypeptides The present invention relates to the preparation of a recombinant polypeptide, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell. In particular, this invention relates to a process to enhance the extraction yield of said recombinant polypeptide from the periplasm before further downstream processing. ... 11/30/06 - 20060269989 - Process for producing antibodies Focusing on the fact that antibody molecules with one H chain are not secreted when using the “knobs-into-holes” method, the present inventors revealed that desired bispecific antibodies can be preferentially formed by first expressing the H and L chains of one arm, and then suppressing their expression, followed by expressing ... 11/30/06 - 20060269988 - Complete biosynthetic gene set for synthesis of polyketide antibiotics, including the albicidin family, resistance genes, and uses thereof Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is ... 11/23/06 - 20060263854 - Immunodiagnostic assays using reducing agents The present invention relates to a solid phase immunoassay comprising on said solid phase an antigen in the presence of a reducing agent. The present invention also relates to a method for purifying a cysteine containing recombinantly expressed protein comprising at least 2, preferably 3 or 4 and even more ... 11/23/06 - 20060263853 - Recombinant il4 antibodies useful in treatment of il4 mediated disorders Chimeric and humanized IL4 A MAbs derived from affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided. ... 11/23/06 - 20060263852 - Asp2 ASP2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP2 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, cancer, and prohormone processing, among others, and diagnostic assays for such conditions. ... 11/23/06 - 20060263851 - Soluble interleukin-20 receptor A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to ... 11/23/06 - 20060263850 - Soluble interleukin-20 receptor A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to ... 11/23/06 - 20060263849 - Glucagon-like peptide-1 analogs Disclosed are glucagon-like peptide-1 (GLP-1) compounds with modifications at one or more of the following positions: 11, 12, 16, 22, 23, 24, 25, 27, 30, 33, 34, 35, 36, or 37. Methods of treating a subject in need of GLP-1 receptor stimulation using these GLP-1 compounds are also disclosed. ... 11/23/06 - 20060263848 - Cysteine-containing peptides having antioxidant properties Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related ... 11/23/06 - 20060263847 - Compositions and methods for treatment of sever acute respiratory syndrome (sars) Compositions and methods for treating Severe Acute Respiratory Syndrome (SARS) are disclosed herein. Inhibitors of SARS-associated inflammatory cytokines are provided herein for use in treating SARS, including SARS-associated coronavirus (SARS-CoV) infection. Inhibitors of TNF are disclosed herein, as is the use of said inhibitors for treating SARS, including SARS-CoV. Methods ... 11/23/06 - 20060263846 - S. penumoniae antigens The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof. ... 11/16/06 - 20060257973 - Pseudomycin production by pseudomonas syringae A method for producing one or more pseudomycins is described including cultures of Pseudomonas syringae that produce one or more pseudomycins having general formula (I) where R is a lipophilic moiety. ... 11/16/06 - 20060257972 - Purification of human monoclonal antibody and human polyclonal antibody This invention provides a method for separating and purifying human monoclonal antibodies and human polyclonal antibodies from an antibody-containing mixture where such antibodies are primarily used for therapeutic applications and are occasionally used for diagnostic and reagent applications. This method comprises at least the following steps of: (1) purification via ... 11/16/06 - 20060257971 - Antibodies to pro1561 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 11/16/06 - 20060257970 - Human hac3 The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes ... 11/09/06 - 20060252126 - Polypeptides having phospholipase b activity and nucleic acids encoding same The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. ... 11/09/06 - 20060252125 - Ice/ced-3 like protease designated fmh-1 Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. ... 11/09/06 - 20060252124 - Methods and compositions for generating human monoclonal antibodies The present invention provides a method for generating human monoclonal antibodies, especially those that are specific for surface antigens representative of a particular cell type. The present invention also includes populations of monoclonal antibodies produced by the invention methods, populations of polynucleotides comprising sequences encoding the immunoglobulins or fragments thereof, ... 11/09/06 - 20060252123 - Glucose dehydrogenase beta subunit and dna encoding the same A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequnece of a N-terminal signal sequence region of a GDH β subunit derived from Burkholderia cepacia KS1 strain. ... 11/09/06 - 20060252122 - A tumor necrosis factor related ligand Nucleic acids that encode Tumor Necrosis Factor Related Ligand (TRELL), a novel member of the tumor necrosis factor family (TNF), modified TRELL, are described. ... 11/09/06 - 20060252121 - Epilepsy mutations An isolated nucleic acid molecule encoding a mutant alpha subunit of a mammalian voltage-gated sodium channel, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled sodium channel comprising this mutated subunit ... 11/09/06 - 20060252120 - Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic ... 11/09/06 - 20060252119 - Fbl2-specific agents as modulators of flaviviridae rna replication Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions wherein but for the presence of the agent, the FBL2 protein and the Flaviviridae protein engage in a reference ... 11/09/06 - 20060252118 - Overexpression, purification and characterization of a thermoolabile phosphatase Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided. Uses for TAP include dephosphorylation of nucleic acids, sugars, peptides and proteins. TAP as described herein has advantages over phosphatases from other sources with respect to thermolability at 65° C. and efficiency ... 11/09/06 - 20060252117 - Metalloprotease proteins This invention relates to proteins termed INSPOO5a and INSPOO5b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. ... 11/09/06 - 20060252116 - Icam-4 binding sites The present invention relates to intercellular adhesion molecule-4 (ICAM-4), including binding sites on ICAM-4, antagonists affecting ICAM-4 and uses thereof. In one aspect of the invention there is provided an epitope for binding integrins, comprising strands A (or F) and G of domain 1 of ICAM-4. In another aspect of ... 11/02/06 - 20060246549 - Peptide acceptor ligation methods Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products. ... 11/02/06 - 20060246548 - Ce7-specific redirected immune cells Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the ... 11/02/06 - 20060246547 - Nematode-extracted serine protease inhibitors and anticoagulant proteins Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized ... 11/02/06 - 20060246546 - Manufacture of biologic cellular products The manufacture of cellular product such as a protein by expression from a cell line in a bioreactor is carried out wherein the bioreactor is a container made of flexible film, at least the interior surface of the container being fluoropolymer, and in addition, the nutrient medium and other agents ... 11/02/06 - 20060246545 - Gene inactivated mutants with altered protein production A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes ... 11/02/06 - 20060246544 - Manufacturing process for the production of peptides grown in insect cell lines The present invention provides a manufacturing method for the production of peptides that are grown in insect cell lines. The peptides are grown in insect cell cultures that are infected with baculovirus particles in a culture supplemented with a lipid mixture. The peptides are then isolated from the insect cell ... 11/02/06 - 20060246543 - Slim compositions and methods of use thereof This invention is based, at least in part, on the discovery of a novel nuclear protein which contains both PDZ and LIM domains, SLIM (STAT-interacting LIM). SLIM interacts with activated STAT molecules. The invention also provides methods of using these novel SLIM compositions. The invention also provides therapeutic methods involving ... 11/02/06 - 20060246542 - System for antibody expression and assembly The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can ... 11/02/06 - 20060246541 - Method of expressing proteins with disulfide bridges This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity. Various approaches are used including fusion to thioredoxin, cytoplasmic expression of disulfide isomerases, deficiencies in thioredoxin and/or glutathione reductases, deficiencies in proteases, and the like. The ... 11/02/06 - 20060246540 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 11/02/06 - 20060246539 - Protein production method utilizing yebf A method of producing a protein or polypeptide, in which an expression vector that encodes a fusion protein comprising the protein or polypeptide peptide located carboxy-terminally to YebF, or a biologically active variant or portion thereof, is expressed in a suitable bacterial cell, to make the fusion protein. The method ... 11/02/06 - 20060246538 - Branched neutral amino acid transporters acting as single molecule It is intended to provide novel amino acid transporters which act as a single molecule and transport neutral amino acids typified by branched amino acids, and genes thereof. A protein consisting of an amino acid sequence represented by SEQ ID NO:2, 4, 6 or 8 or an amino acid sequence ... 10/26/06 - 20060240523 - Endogenous and non-endogenous versions of human g protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity. ... 10/26/06 - 20060240522 - Process for bacterial production of polypeptides Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic acid encoding phage lysozyme and nucleic acid encoding the heterologous polypeptide under separate promoters, disrupting the cells mechanically to release the phage lysozyme so ... 10/26/06 - 20060240521 - Dna sequences for regulating transcription The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA polymerase binds which DNA sequence comprises a mRNA initiation site; and further (b) one or more DNA sequence(s) to ... 10/26/06 - 20060240520 - Novel receptor nucleic acids and polypeptides Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. ... 10/26/06 - 20060240519 - Novel receptor nucleic acids and polypeptides Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. ... 10/26/06 - 20060240518 - Novel receptor nucleic acids and polypeptides Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. ... 10/26/06 - 20060240517 - Novel receptor nucleic acids and polypeptides Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. ... 10/26/06 - 20060240516 - Interacting polypeptide comprising a heptapeptide pattern and a cell penetration domain The invention relates to an interacting polypeptide consisting of or comprising a heptapeptide pattern of sequence X1X2X3X4X5X6X7 and a transduction domain, characterized in that it is a chimera polypeptide, the amino acid X7 is located between 5 and 35 amino acids of the C-terminal end of said polypeptide, and that ... 10/26/06 - 20060240515 - Soluble fragments of the sars-cov spike glycoprotein The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins ... 10/26/06 - 20060240514 - Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-products using non-animal based products to replace the animal-derived products. Preferably, the media used are substantially ... 10/26/06 - 20060240513 - Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant ... 10/26/06 - 20060240512 - Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes, and uses thereof The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing ... 10/26/06 - 20060240511 - Purification of her-2 variants The present invention provides for a novel method for purification of EGFR family proteins obtained from cultures of insect cells. The process comprises subsequent steps of a) diafiltration and exchange of culture medium with buffer, b) immobilized metal affinity chromatography (IMAC), c) size exclusion chromatography (SEC), and d) anion exchange ... 10/26/06 - 20060240510 - Method for designing peptides The present invention relates to genetic engineering and; in specific, to design, generation, and modification of recombinant peptides using a combination of phage display and intein-mediated protein cleavage reaction. ... 10/26/06 - 20060240509 - Myrothecium sp transformation and expression system The present invention is related to a transformation and an expression system in which Myrothecium sp. host cells are used to express homologous or heterologous proteins or are used to genetically engineer metabolic pathways. ... 10/19/06 - 20060234350 - Endogenous and non-endogenous versions of human g protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown, and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity. ... 10/19/06 - 20060234349 - Fungal cell wall synthesis gene A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these ... 10/19/06 - 20060234348 - Method of production of rna polymerase protein A method of forming a stable RNA polymerase enzyme by expressing protein 2a in cells, pelleting the cells expressing protein 2a, macerating the cells expressing protein 2a to obtain a cell lysate, and filtering the cell lysate through an affinity resin. A stable RNA polymerase enzyme for copying RNA in ... 10/19/06 - 20060234347 - Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors Multivalent soluble receptor proteins that bind to more than one angiogenic factor are described. Nucleotide and vector sequences which encode the multivalent soluble receptor protein, as well as host cells which comprise them and methods of making and using them are also described. The multivalent soluble receptor proteins and vectors ... 10/19/06 - 20060234346 - Expression of mammalian proteins in pseudomonas fluorescens The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances Processes for improved ... 10/19/06 - 20060234345 - Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment. ... 10/19/06 - 20060234344 - Protein kinases The present invention relates to novel kinase polypetides, nucleotide sequences encoding the novel kinase polypetides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related disease and conditions. ... 10/19/06 - 20060234343 - Truncated egf receptor The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules. ... 10/19/06 - 20060234342 - Human dna topoisomerase i alpha Disclosed is a human is a hTopI-α polypeptide and DNA (RNA) encoding such hTopI-α polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of ... 10/19/06 - 20060234341 - Process for producing phosphorylase It is intended to provide a process for conveniently producing phosphorylase at a high purity using a phosphorylase-producing microorganism. Namely, a process for producing phosphorylase characterized by culturing a phosphorylase-producing microorganism in a medium containing phosphoric acid or its salt at a concentration of 50 mM or above and collecting ... 10/19/06 - 20060234340 - Human heavy chain antibody expression in flamentous fungi The present invention relates to a method for producing a functional human immunoglobulin, wherein a human heavy chain immunoglobulin, devoid of any light chain, is expressed, comprising the steps of: a) transforming a filamentous host cell with a recombinant construct encoding a modified human heavy chain immunoglobulin, wherein the modifications ... 10/19/06 - 20060234339 - Method of expressing protein having unnatural amino acid integrated thereinto A method of expressing a protein having an unnatural amino acid integrated thereinto characterized by comprising expressing (A) a mutant tyrosyl tRNA synthase which is a mutant of Escherichia coli-origin tyrosyl tRNA synthase and has an elevated specificity for a unnatural tyrosine derivative compared with the specificity for tyrosine, (B) ... 10/19/06 - 20060234338 - Isomaltose synthase-knockout microorganism belonging eumycota It is intended to provide a host microorganism whereby the expression of a gene encoding a target protein can be effectively elevated in the case of transferring the gene. It is also intended to provide a transformant whereby a target protein can be produced at a high efficiency. It is ... 10/19/06 - 20060234337 - Expression system for actinomycete-origin cytochrome p-450 in escherichia coli This invention relates to a system for the expression of cytochrome P-450 gene in host Escherichia coli, and provides Escherichia coli which contains actinomycete ferredoxin gene and also ferredoxin gene and ferredoxin reductase gene which are xenogenic to Escherichia coli. Thus, this invention is useful for the promotion of effective ... 10/19/06 - 20060234336 - Methylotrophic bacterium for the production of recombinant proteins and other products The present invention relates to a method of producing a recombinant peptide, a recombinant protein, or a product from metabolic engineering using a genetically modified methylotrophic bacterium, and more particularly to Methylobacterium extorquens ATCC 55366. The method comprises introducing am expression vector into the methylotrophic bacterium, the expression vector comprising ... 10/12/06 - 20060228780 - Chromatographic method and system for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... 10/12/06 - 20060228779 - Method for producing factor g derived from horseshoe crab The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily and at low cost, a cell harboring the virus, and a method of producing factor G by use of the cell. ... 10/12/06 - 20060228778 - Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof The present invention relates to novel vitamin D receptor related (VDRR) polypeptides, and formulations containing the same. Nucleic acid sequences encoding the VDRR polypeptides, expression vectors containing such sequences and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel VDRR ... 10/12/06 - 20060228777 - Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-products using non-animal based products to replace the animal-derived products. Preferably, the media used are substantially ... 10/12/06 - 20060228776 - Pink-1 promoter The invention provides methods and compositions of an upstream regulatory element (PINK-1 promoter) operably linked to an expressible gene, wherein the expression of the expressible gene is driven by the upstream regulatory element. ... 10/12/06 - 20060228775 - Differential expression of nucleic acid molecules The present invention relates generally to nucleic acid molecules expressed at least in the hypothalamus, liver, mesenteric adipose tissue, or red gastrocnemius muscle conveniently identified using differential display techniques under differing physiological conditions. The nucleic acid molecules are associated with or act as markers for conditions of inter alia a ... 10/12/06 - 20060228774 - Oxygen-resistant hydrogenases and methods for designing and making same The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H2. Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases are disclosed, as are the methods of transforming and culturing appropriate host cells with the oxygen-resistant [Fe]-hyrdogenases. Finally, the invention provides methods for utilizing the transformed, ... 10/12/06 - 20060228773 - Method for preparing recombinant heterocarpine A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells ... 10/05/06 - 20060223143 - Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. ... 10/05/06 - 20060223142 - Extended cdnas for secreted proteins The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping ... 10/05/06 - 20060223141 - Transcription amplification system for molecular imaging The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product in a cell-type, specific manner. The present invention also relates to methods for producing, detecting, imaging, and monitoring the heterologous gene product in ... 09/28/06 - 20060216788 - Cash (caspase homologue) with death effector domain, modulators of the function of fas Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use. ... 09/28/06 - 20060216787 - Modified shine-dalgarno sequences and methods of uses thereof Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, ... 09/28/06 - 20060216786 - Feline interferon-alpha proteins The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine ... 09/28/06 - 20060216785 - Methods and compositions for protein expression and purification Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed. ... 09/28/06 - 20060216784 - Process for production of polypeptides Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous ... 09/28/06 - 20060216783 - Polypeptide factor from a thermophilic eubacterial species and use thereof in the production of functional, heterologous proteins in an expression host A polypeptide factor derived from the thermophilic eubacterial species Thermus thermophilus has universal protein expression-assisting activity. The polypeptide factor has been named the CzrB protein active in full length or truncated form has the potential to act as a universal protein expression-assisting molecule which can increase the yields of all ... 09/28/06 - 20060216782 - Methods for expression and purification of immunotoxins In one aspect the present invention relates to a method of expressing an immunotoxin in Pichia pastoris strain mutated to toxin resistance comprising a) growing the Pichia pastoris in a growth medium comprising an enzymatic digest of protein and yeast extract and maintaing a dissolved oxygen concentration at 40% and ... 09/21/06 - 20060211094 - Glucose dehydrogenase beta subunit and dna encoding the same A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequnece of a N-terminal signal sequence region of a GDH β subunit derived from Burkholderis cepacia KS1 strain. ... 09/21/06 - 20060211093 - Membrane scaffold proteins and embedded membrane proteins Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their ... 09/21/06 - 20060211092 - Membrane scaffold proteins and tethered membrane proteins Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their ... 09/21/06 - 20060211091 - Mage-a3 peptides presented by hla class ii molecules The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized ... 09/21/06 - 20060211090 - Human cdnas and proteins and uses thereof The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for ... 09/21/06 - 20060211089 - Expression of defensins in filamentous fungi The present invention relates to recombinant expression of defensin antimicrobial peptides in fermentation of filamentous fungi. ... 09/21/06 - 20060211088 - Method for generating variable domain sequences of heavy chain antibodies The present invention relates to a method for generating or cloning a nucleic acid or nucleotide sequence that encodes a heavy chain antibody or an antigen-binding fragment thereof, wherein said heavy chain antibody or antigen-binding fragment is directed against a specific antigen, said method comprising the steps of providing a ... 09/21/06 - 20060211087 - Compositions and methods for producing recombinant proteins A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described are methods of using Mistic polypeptides and Mistic fusion proteins to produce and/or isolate ... 09/21/06 - 20060211086 - Process for manufacture of nematode-extracted anticoagulant protein (nap) The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug substance that can be formulated as a NAP drug product. The present invention provides NAP drug substances and NAP drug products manufactured by ... 09/21/06 - 20060211085 - Methods for reducing or eliminating alpha-mannosidase resistant glycans for the production of glycoproteins The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR2 gene encoding β1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors ... 09/21/06 - 20060211084 - Simplified eukaryotic nitrate reductase The invention provides modification to the polynucleotide coding sequence for Pichia angusta NAD (P)H: nitrate reductase [YNaR1; GenBank accession number Z49110], which has Enzyme Commission number 1.7.1.2 (formerly EC 1.6.6.2), yielding the polynucleotide coding sequence for simplified eukaryotic nitrate reductase (S-NaR1). The invention also provides a method for recombinant expression ... 09/14/06 - 20060205035 - Biologic variability of asthma associated factors useful in treating and diagnosing atopic allergies including asthma and related disorders This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is deleted resulting in the loss of glutamine 173 ... 09/14/06 - 20060205034 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the ... 09/14/06 - 20060205033 - Infectious clones of rna viruses and vaccines and diagnostic assays derived thereof An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA virus, transfecting the host cell with ... 09/14/06 - 20060205032 - Hslim modulates immune responses Human SLIM polypeptides for use in modulating STAT-dependent gene transcription. ... 09/14/06 - 20060205031 - Newly identified cholinephosphotransferases and ethanolaminephosphotransferases The present invention relates to polypeptides comprising one or more of the amino acid motifs selected from the group consisting of a sequence with at least 80% identity to any of (a) P-L-X-D-X(35,75)-R-R-X(8)-[YF]-X(2)-R-X(6)-T (b) C-X-D-X(3)-S-G-H-T (c) H-Y-[TS]-X-D-[VI]-X(3)-[FYI]-X(6)-F-X(2)-Y-H, which transfer phosphocholine and phosphoethanolamine, nucleotide sequences coding for any of these polypeptides ... 09/07/06 - 20060199250 - Method for generating a mutant protein which efficiently binds a target molecule The present invention relates to a method for generating a mutant protein which efficiently binds a target molecule. The method of the invention employs saturation mutagenesis and random mutagenesis approaches producing one or more mutant proteins with enhanced binding efficiency for a target molecule compared to binding of a wild-type ... 09/07/06 - 20060199249 - Method for protein production To provide a novel method for obtaining a protein of interest efficiently in a soluble form when the protein is produced by expressing a foreign gene in host cells such as microorganisms etc. In a method for, by culturing host cells into which a foreign gene has been introduced, producing ... 09/07/06 - 20060199248 - Q3 sparc deletion mutant and uses thereof The invention provides for SPARC polypeptides with a mutation corresponding to a deletion of the third glutamine in the mature form of the human SPARC protein, nucleic acids encoding such polypeptides, antibodies against such polypeptides, and methods of the use of such polypeptides, nucleic acids, and antibodies. ... 09/07/06 - 20060199247 - Method for identifying modulators gene expression A method of cloning mammalian genes encoding proteins which can function in microorganisms, particularly yeast, and can modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the micro-organism. It further relates to mammalian genes cloned by the present method, as well as to ... 09/07/06 - 20060199246 - Zinc-regulated prokaryotic expression cassettes The invention concerns prokaryotic expression cassettes comprising a promoter zinc-regulated by a L. lactis zitR repressor. Said cassettes can be used for expressing genes of interest in gram-positive bacteria. ... 08/31/06 - 20060194291 - Polypeptide variants with altered effector function The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof. ... 08/31/06 - 20060194290 - Polypeptide variants with altered effector function The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof. ... 08/31/06 - 20060194289 - Method of production of recombinant proteins in eukaryote cells The invention provides a method for production of polypeptides in eukaryote microcarrier cell culture, the method comprising the steps of (i) Culturing cells expressing said polypeptide on microcarriers under conditions and at a setpoint temperature appropriate for expression of said polypeptide; (ii) Cooling the culture to a predetermined temperature below ... 08/31/06 - 20060194288 - Nucleic acid molecules encoding endonucleases and methods of use thereof We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective amount of enzymes having strand cleavage activity, 3′ to 5′ exonuclease activity, and ... 08/31/06 - 20060194287 - Chemokine-binding protein and methods of use Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine-binding domain of a THAP-family polypeptide. Also disclosed are methods of binding chemokines, inhibiting the activity of chemokines, detecting chemokines, and reducing the symptoms associated with a chemokine mediated or influenced condition by ... 08/31/06 - 20060194286 - Apo-2li and apo-3 polypeptides Novel polypeptides, designated Apo-3 and Apo-2LI, involved in apoptosis are provided. Compositions including chimeric molecules, nucleic acids, and antibodies are also provided. ... 08/31/06 - 20060194285 - Biological production of clavulanic acid and related compounds Disruption of the two-component regulatory system encoded by the cbsA locus is associated with improved production of cephamycin C and/or clavulanic acid in Streptomyces clavuligerus. ... 08/31/06 - 20060194284 - Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. ... 08/31/06 - 20060194283 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 08/31/06 - 20060194282 - Fluorescent protein variants and methods for making same The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomeric structures. The invention also ... 08/31/06 - 20060194281 - Novel hcv core‘protein, methods for diagnosis of hcv infections, prophylaxis, and for screening of anti-hcv agents The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a nucleotide sequence extending from ... 08/31/06 - 20060194280 - Methods for refolding of recombinant antibodies The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent. ... 08/31/06 - 20060194279 - Protein-refolding material The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding ... 08/31/06 - 20060194278 - Process for producing glucose dehydrogenase A glucose dehydrogenase complex is produced by culturing an Escherichia bacterium, which is introduced with DNAs encoding the α-subunit and the β-subunit of glucose dehydrogenase of Burkhorderia cepacia in an expressible form, and in which expression of the ccm system (cytochrome c maturation system) is enhanced, to express the aforementioned ... 08/31/06 - 20060194277 - Method for producing target proteins by deleting or amplifyingibpa and/or ibpb gene coding for inclusion body-associated proteins A method for producing target proteins by deleting or amplifying ibpA and/or ibpB genes coding for inclusion body-associated proteins. Two methods for producing target proteins using ibpA and/or ibpB genes coding for inclusion body-associated proteins of E. coli are described, The first method enhances the secretory production and activity of ... 08/31/06 - 20060194276 - Specificity grafting of a murine antibody onto a human framework The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework. ... 08/31/06 - 20060194275 - Transporter and ion channels The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH. ... 08/24/06 - 20060188962 - 19 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 08/24/06 - 20060188961 - Intergenic regions as novel sites for insertion of hiv dna sequences in the genome of modified vaccinia virus ankara The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives. ... 08/24/06 - 20060188960 - Chimeric histamine h3 receptor Chimeric H3 receptor polypeptides are provided, as are polynucleotides encoding such polypeptides, and vectors and cells for recombinant expression of such polypeptides. Chimeric H3 receptor polynucleotides and polypeptides may be used, for example, to identify agents that specifically interact with H3 receptor. Such agents find use within therapies for humans ... 08/24/06 - 20060188959 - Crystal structure of worm nitfhit reveals that a nit tetramer binds tow fhit dimers In invertebrates, Fhit is encoded as a fusion protein with Nit. Outside of invertebrates, Nit homologs are found as separate polypeptides in organisms with Fhit homologs. Therefore, Nit and Fhit are expected to interact physically and function in the same cellular pathway. The structure of the NitFhit fusion protein and ... 08/24/06 - 20060188958 - Artificial enzyme and method for producing the same The method for producing an artificial enzyme according to the invention is a method for producing an artificial enzyme and includes the step of selecting an artificial enzyme precursor which includes an oligonucleotide sequence containing modified nucleosides prepared by introducing a substituent into each nucleoside and at least one of ... 08/24/06 - 20060188957 - Novel tnf receptor death domain ligand proteins and inhibitors of ligand binding Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death ... 08/24/06 - 20060188956 - Relaxin3-gpcr135 complexes and their production and use A GPCR135/relaxin3 complex is described, which is useful as an assay reagent for screening for modulators of GPCR135 receptor activity. ... 08/17/06 - 20060183196 - Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and ... 08/17/06 - 20060183195 - Transgenic non-human animals for producing heterologous antibodies The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence antibodies. ... 08/17/06 - 20060183194 - Heregulin variants The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-β1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can ... 08/17/06 - 20060183193 - Vectors and methods for high throughput co-expression The present invention includes vectors and methods for high throughput co-expression. ... 08/17/06 - 20060183192 - Modulation of sodium channels in dorsal root ganglia A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+ current through the receptor are provided, as well as related therapeutic and diagnostic methods. ... 08/17/06 - 20060183191 - Synthetic approach to designed chemical structures This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. ... 08/17/06 - 20060183190 - Novel transporter protein A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to ... 08/17/06 - 20060183189 - Regulatable gene expression in mammalian cells and mammals The present invention discloses mammalian cells useful for regulated gene expression in response to compounds being gaseous or liquid at the cultivation temperature of said mammalian cell, and non-human mammals comprising such mammalian cells. The invention further discloses methods for producing proteins in mammalian cells in a regulated way in ... 08/17/06 - 20060183188 - Genes from propionibacterium freudenreichii encoding enzymes involved in vitamin b12 biosynthesis Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway of vitamin B12. The four enzymes are: A: cobyrinic acid a, c-diamide synthase; B: a bifunctional enzyme, which is a ... 08/17/06 - 20060183187 - Gene and polypeptide sequences The present invention provides a polypeptide comprising (i) a leader sequence, the leader sequence comprising a (a) secretion pre sequence, and (b) the following motif: -X1-X2-X3-X4-X5- where X1 is phenylalanine, tryptophan, or tyrosine, X2 is isoleucine, leucine, valine, alanine or methionine, X3 is leucine, valine, alanine or methionine, X4 is ... 08/17/06 - 20060183186 - Gene expression profiles in stomach cancer The present invention results from the examination of tissue from stomach tumors to identify genes that are differentially expressed between cancerous and normal tissue. The invention includes diagnostic, monitoring, drug design and therapeutic methods using these genes, as well as solid supports comprising oligonucleotide arrays that are complementary to or ... 08/10/06 - 20060177907 - Methods and materials for characterizing and modulating interaction between heregulin and her3 The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein ... 08/10/06 - 20060177906 - Igf-i responsive gene and use thereof A protein encoded by a gene comprises nucleic acid sequence SEQ ID No. 1, 2, 3, 4, 5, 6 or a derivative or mutant or fragment or variant or peptide thereof. The protein promotes the attachment and modulates the motility and invasion capability of cells. ... 08/10/06 - 20060177905 - Udp-glucosyltransferases This invention pertains to nucleic acid fragments encoding plant glucosyltransferases, heretofore undescribed, that exhibit catalytic activity with p-hydroxybenzoic acid (pHBA) as a substrate and only attach glucose to the aromatic carboxyl group of pHBA, to form the pHBA glucose ester. These enzymes have potential applications both in vitro and in ... 08/10/06 - 20060177904 - Secreted proteins and polynucleotides encoding them Novel polynucleotides and the proteins encoded thereby are disclosed. ... 08/10/06 - 20060177903 - Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention ... 08/10/06 - 20060177902 - Cytokine receptor chain Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. ... 08/10/06 - 20060177901 - Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor. ... 08/10/06 - 20060177900 - Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing ... 08/10/06 - 20060177899 - 14273 receptor, a novel g-protein coupled receptor The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, ... 08/10/06 - 20060177898 - Methods for producing modified glycoproteins Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower ... 08/10/06 - 20060177897 - Pr1550 polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 08/10/06 - 20060177896 - Anti-cd3 antibodies and methods of use thereof The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy ... 08/10/06 - 20060177895 - Methods for enhancing expression of recombinant proteins The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system. ... 08/10/06 - 20060177894 - Protein knobs Compositions containing a knob attached to a specific site of a protein and methods of producing and using these compositions are disclosed. The compositions comprise a knob, a tail portion and a protein portion. The protein portion contains a substituted cysteine residue at the desired location of labeling. The tail ... 08/03/06 - 20060172391 - Bmp-11 compositions Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective ... 08/03/06 - 20060172390 - Consensus phytases A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins. ... 08/03/06 - 20060172389 - Canine erythropoietin gene and recombinant protein One aspect of the present invention is an isolated nucleic acid molecule encoding canine erythropoietin. The present invention also relates to an isolated canine erythropoietin protein or polypeptide. Another aspect of the present invention is a method for providing erythropoietin therapy to a dog or a cat including administering recombinant ... 08/03/06 - 20060172388 - Methods for enhancing expression of recombinant proteins The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system. ... 08/03/06 - 20060172387 - Chimeric avidin mutants The present invention relates to new chimeric mutants of avidin protein with improved properties, e.g. thermostability, better stability against proteolysis, better charge properties (for example lower pl) compared to native avidin and avidin-related proteins, AVRs. The chimeric avidin mutants comprise mutants where a region or regions in avidin are substituted ... 08/03/06 - 20060172386 - Human fgf-20 gene and gene expression products This invention relates to human fibroblast growth factor (hFGF-20), and to variants thereof and to polynucleotides encoding FGF-20. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, to methods of treating neuronal degenerative disease such as Parkinson's disease and to ... 08/03/06 - 20060172385 - Methods for producing soluble membrane-spanning proteins Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in ... 08/03/06 - 20060172384 - Fgf18 production in prokaryotic hosts The expression vectors and methods using an E. coli expression system for the large scale production of FGF18 are described. The vectors utilize the FGF18 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, ... 08/03/06 - 20060172383 - Process for constructing strain having compactin hydroxylation ability The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to ... 08/03/06 - 20060172382 - Selection of host cells expressing protein at high levels The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of interest, the polypeptide of interest having a translation initiation sequence separate from that of the selectable marker polypeptide, characterized in ... 08/03/06 - 20060172381 - Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins The present invention provides methods and compositions for generating novel nucleic acid molecules through RNA trans-splicing that target a highly expressed pre-mRNA and contain the coding sequence of a protein or polypeptide of interest. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with the target precursor ... 08/03/06 - 20060172380 - Tab1 protein and dna coding therefore TAB1 protein having activity which activates factor TAK1 in the TGF-β signaling pathway, and having the amino acid sequence shown in FIG. 1. ... 08/03/06 - 20060172379 - Methods for transforming and expression screening of filamentous fungal cells with a dna library The present invention relates to methods for expression screening of filamentous fungal transformants, comprising: (a) isolating single colony transformants of a DNA library introduced into E. coli; (b) preparing DNA from each of the single colony E. coli transformants; (c) introducing a sample of each of the DNA preparations of ... 08/03/06 - 20060172378 - Variants of protein kinases The present invention concerns nucleic acid sequences and amino acid sequences of dominant negative variants of kinases, i.e. of sequences which inhibit activity of kinases in a dominant manner. The invention also concerns pharmaceutical compositions and detection methods using these sequences. ... 08/03/06 - 20060172377 - Site-specific serine recombinases and methods of their use The present invention provides a method for obtaining site-specific recombination in a eukaryotic cell, the method comprising providing a eukaryotic cell that comprises a first recombination attachment site and a second recombination attachment site; contacting the first and second recombination attachment sites with a prokaryotic recombinase polypeptide, resulting in recombination ... 08/03/06 - 20060172376 - Method and device for the continuous production of biomolecules The invention relates to a method and device for the continuous production of endogenous or recombinant native polypeptides. The method and device comprise the steps of cultivating recombinant microorganisms in a bioreactor, withdraw a sample of the microbial suspension in the reactor in a continuous manner and subject the same ... 08/03/06 - 20060172375 - D-aminoacylase A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like, ... 08/03/06 - 20060172374 - Phosphorylated ndr kinase The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular biology, chemistry, pharmacology, and screening technology. ... 08/03/06 - 20060172373 - Mutant recombinases The invention provides hyperactive mutant recombinases and hybrid mutant recombinases, and methods for their identification. Also provided are nucleic acids encoding hyperactive mutant recombinases and hybrid recombinases, as well as vectors and host cells. Host cells include eukaryotic cells capable of expressing said recombinases and carrying out site-specific recombination in ... 07/27/06 - 20060166327 - Human g-protein receptor hgber32 Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat ... 07/27/06 - 20060166326 - 32142, 21481, 25964, 21686, novel dehydrogenase molecules and uses therefor The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which ... 07/27/06 - 20060166325 - Glial cell line-derived neurotrophic factor receptor The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of a high affinity receptor for ... 07/27/06 - 20060166324 - Screening tools for discovery of novel anabolic agents The disclosure provides nucleic acids including the polynucleotide sequence of the human MAFbx core promoter involved in muscle specific expression. Also provided are reporters operably linked to a polynucleotide sequence including MAFbx transcription regulatory sequences, and constructs including polynucleotides that encode reporters and other polynucleotide sequences operably linked to the ... 07/27/06 - 20060166323 - Compositions comprising promoter sequences and methods of use Nucleic acid molecules, fragments and variants thereof having promoter activity are provided in the current invention. The invention also provides vectors containing a nucleic acid molecule of the invention and cells comprising the vectors. Methods for making and using the nucleic acid molecules of the invention are further provided. ... 07/27/06 - 20060166322 - Egvi endoglucanase and nucleic acids encoding the same The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same. ... 07/27/06 - 20060166321 - Recombinant influenza vectors with tandem transcription units The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or PolII promoters. ... 07/27/06 - 20060166320 - In vitro expression of the hcv arfp/f-core‘coding open reading frame A method of producing and purifying an HCV polypeptide, wherein the method comprises providing host cells containing an expression vector comprising a polynucleotide operably linked to expression control elements, wherein the polynucleotide is an open reading frame that overlaps the core gene in the +1 frame (core+1 ORF) of HCV, ... 07/27/06 - 20060166319 - Charging trna with pyrrolysine Provided herein is a method for preparing a cell that, when exposed to the non-canonical amino acid, pyrrolysine or a derivative thereof and transformed or transfected with a polynucleotide comprising an in-frame UAG or TAG codon incorporates the pyrrolysine residue or derivative thereof into the protein or polynucleotide into the ... 07/27/06 - 20060166318 - Methods, compositions, and cells for encapsidating recombinant vectors in aav particles Isolated recombinant polynucleotides comprising elements which promote encapsidation into AAV particles, packaging cells comprising the recombinant polynucleotides, and methods for their use are provided in the present invention. These isolated recombinant polynucleotides comprise a non-AAV ITR encapsidation element (such as the P1 sequence located within the AAV S1 integration site ... 07/27/06 - 20060166317 - Nucleic acids encoding sialytransferases from c. jejuni This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter ... 07/27/06 - 20060166316 - Phosphodiesterase 10a7 isoforms and methods of use The invention relates to mammalian phosphodiesterase PDE10A7 isoforms, as well as the nucleic acids encoding such polypeptides. The invention further relates to methods for utilizing such polypeptides in diagnostic assays and in methods of screening potential modulators, especially inhibitors, of the novel PDE10A7 disclosed herein. The polypeptides of the invention ... 07/27/06 - 20060166315 - Process for producing pnpase The invention provides a process for producing PNPase, wherein PNPase can be produced easily with high efficiency, and problematic contamination with endotoxin in synthesis of a nucleic acid polymer as a raw material of pharmaceutical preparations can be reduced. PNPase is produced by Escherichia coil or the like having a ... 07/27/06 - 20060166314 - Method for rational mutagenesis of alpha/beta t-cell receptors and correspondingly mutated mdm2-protein specific alpha/beta t-cell ceceptores The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been ... 07/27/06 - 20060166313 - Novel glycero kinase, gene thereof and process for producing the glycerol kinase by using the gene Relating to a gene encoding a new glycerol kinase and a method for preparing the enzyme by gene recombination technique. A Glycerol kinase which has high resistance against preservative, a recombinant vector comprising a gene encoding the glycerol kinase, a transformant prepared by transforming a host cell with the recombinant ... 07/27/06 - 20060166312 - Novel microorgnaism sensitive to lysozyme A microorganism of the genus Rhodococcus is provided which has a higher sensitivity to lysozyme at a low concentration than a wild-type strain, which can easily cause cell lysis, and from which a recombinant protein expressed therein is easily recovered. More specifically, a mutant microorganism of the genus Rhodococcus having ... 07/27/06 - 20060166311 - Novel notch-origin polypeptides and biomarkers and reagents using the same It is intended to provide extracellular markers whereby Notch signal transduction can be detected. Polypeptides (Nβ), which are novel peptides originating in Notch protein and released form cells in the step of the nuclear migration of NICH (Notch intracellular cytoplasmic domain) due to the extracellular digestion and the subsequent protein ... 07/27/06 - 20060166310 - Serotonin receptor This invention relates to a protein, termed INPIONCH1, herein identified as a 5-HT3 receptor and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease. ... 07/27/06 - 20060166309 - Novel g-protein coupled receptors The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of G-protein coupled receptors. ... 07/20/06 - 20060160186 - Nucleic acid underexpressed in stomach tumor and lung tumor The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 07/20/06 - 20060160185 - Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and ... 07/20/06 - 20060160184 - Fab library for the preparation of anti vegf and anti rabies virus fabs The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising ... 07/20/06 - 20060160183 - Vaccines and immunotherapeutics derived from the human immunodeficiency virus (hiv) transactivator of transcription protein for the treatment and prevention of hiv disease Anti-lentivirus vaccines and immunotherapeutics and methods for preparing and using same are disclosed. The vaccines and immunotherapeutics are produced using non-immunosuppressive lentivirus trans-activator of transcription (Tat) proteins. An associated in vitro ultra-sensitive macrophage Tat bioassay is disclosed for assessing the immunosuppressive qualities of the lentivirus Tat preparations of the present ... 07/20/06 - 20060160182 - Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production The present invention provides methods and compositions for generating novel nucleic acid molecules through RNA trans-splicing that target a highly expressed pre-mRNA and contain the coding sequence for antibody polypeptide(s). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with the target precursor messenger RNA molecule (target ... 07/20/06 - 20060160181 - Fibroblast growth factor-23 molecules and uses thereof The present invention provides Fibroblast Growth Factor-23 (FGF-23) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGF-23 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, ... 07/20/06 - 20060160180 - Production of alpha-abeta An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a ... 07/20/06 - 20060160179 - Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated P. pastoris MNN4B gene. The present invention further relates to methods for producing modified ... 07/20/06 - 20060160178 - Methods of generating antibody diversity in vitro The present invention provides a high throughput method for generating fully human monoclonal antibodies. ... 07/20/06 - 20060160177 - Peptide extended glycosylated polypeptides Glycosylated polypeptides comprising the primary structure NH2-X-Pp-COOH, wherein X is a peptide addition comprising or contributing to a glycosylation site, and Pp is a polypeptide of interest or comprising the primary structure NH2-Px-X-Py-COOH, wherein Px is an N-terminal part of a polypeptide Pp of interest, Py is a C-terminal part ... 07/20/06 - 20060160176 - Functional assays for identifying compounds that modulate t1r1/t1r3 (umami) taste Functional assays for identifying compounds that activate or modulate the activation of the T1R1/T1R3 (umami) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R1/T1R3 (umami) taste receptor or on the activation of T1R1/T1R3 umami taste receptor by another compound e.g., ... 07/20/06 - 20060160175 - Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include leucyl orthogonal tRNAs, leucyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of leucyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs. ... 07/20/06 - 20060160174 - Modified l49-sfv exhibiting increased stability and methods of use thereof The present invention relates to a modified L49 single chain antibody (L49-sFv) that exhibits increased refolding efficiency and/or greater stability in mouse serum, and surprisingly substantially maintains binding affinity for its binding ligand, p97 melanotransferrin. p97 melanotransferrin is expressed on the surface of a number of types of cancer (carcinoma) ... 07/20/06 - 20060160173 - Feedback-resistant homoserine transsuccinylases having a modified c terminus The invention relates to a homoserine transsuccinylase, which exhibits reduced sensitivity towards L-methionine or SAM in comparison with a homoserine transsuccinylase wild-type enzyme, whereby the latter comprises an amino acid sequence containing a TyrGlnXaaThrPro sub-sequence, the Thr of said sub-sequence lying between positions 285 and 310 of the amino acid ... 07/13/06 - 20060154339 - Novel clock gene bmal2 The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the proteins to screen a promoter or a suppressor of the promoter transactivation, and the like. ... 07/13/06 - 20060154338 - Novel antibiotic alternatives The present invention relates to two recombinant colicin expression systems, one utilizing a yeast expression system that produces a protein that is inexpensive to purify, and the other utilizing a plasmid expression system to be used as a probiotic culture. The recombinant colicins provide effective alternatives to conventional antibiotics and ... 07/13/06 - 20060154337 - Gene encoding chondroitinase abc and uses therefor Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABC protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABC protein are described. Chondroitinase ABC prepared by chemical synthesis is also described. Monoclonal and ... 07/13/06 - 20060154336 - Nucleic acid molecules for optimized cab-2 expression and their use The invention provides for nucleic acid molecules encoding a CAB-2 protein and variants thereof. The invention also provides constructs, transformed eukaryotic cells, and methods of producing CAB-2 protein and variants thereof. ... 07/13/06 - 20060154335 - Novel members of the steroid/thyroid superfamily and uses therefor Novel peroxisome proliferators-activated receptor subunits designated PPARγ and PPARδ are described. Nucleic acid sequences encoding the receptor subunits, expression vectors containing such sequences and host cells transformed with such vectors are also disclosed, as are heterodimeric PPAR receptors comprising at least one of the invention subunits, and methods for the ... 07/13/06 - 20060154334 - Method of producing an antibody to epidermal growth factor receptor The present invention is directed to a method of producing an antibody to Epidermal Growth Factor Receptor (EGFR). The method includes producing transformed cells that express EGFR antibodies, culturing the transformed cells, harvesting the transformed cells to collect the EGFR antibodies, and purifying the EGFR antibodies. ... 07/13/06 - 20060154333 - Pan-her antagonists and methods of use The present invention features human epidermal receptor (HER) antagonists. These antagonists are polypeptide variants of ligands of HER. The HER ligand polypeptide variants of the invention possess Pan-HER antagonistic properties and can inhibit at least one HER-mediated biological activity of one or more HER subtypes, such as inhibition of the ... 07/13/06 - 20060154332 - Selective capture and enrichment of proteins expressed on the cell surface The present invention provides a method for enriching cell surface proteins by oxidizing glycosylated protein with periodate. The present invention further provides that the cell surface proteins are obtained from intact cells either from cell lines or from tissues. The present invention provides a method not only capable of obtaining ... 07/13/06 - 20060154331 - Erythrocyte differentiation factor, gene encoding same, and methods of use thereof The present invention relates to an erythrocyte differentiation factor designed Codanin-1, and to an isolated nucleic acid which encodes for the differentiation factor. Mutations in the differentiation factor are associated with Congenital Dyserythropoietic Anemias (CDA), a group of inherited red blood cell disorders associated with dysplastic changes in late erythroid ... 07/13/06 - 20060154330 - Akap18 delta, a novel splicing variant of a protein kinase a anchor protein and the use of the same The invention relates to a nucleic acid sequence encoding a protein kinase A anchor portein, to the use of said nucleic acid sequence in a fusion protein, to a method of determining the interaction of said protein kinase A anchor protein with regulatory subunits of protein kinase A, and to ... 07/13/06 - 20060154329 - Expression system The present invention provides a recombinant polynucleotide, the polynucleotide comprising a first and a second sequence, the first sequence encoding a signal peptide comprising a TAT signal and a Sec avoidance signal and the second sequence encoding a heterologous protein. The sequence of the signal peptide is M-X1—K/R—X2—K/R—X3—RR—X4—K/R-A in which ... 07/06/06 - 20060148037 - Polynucleotides encoding potassium channels The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes. ... 07/06/06 - 20060148036 - Gabaalpha receptor epsilon subunits The present invention relates to a novel GABAA receptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing ... 07/06/06 - 20060148035 - Methods for producing modified glycoproteins Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower ... 07/06/06 - 20060148034 - Method for preventing and/or treating viral infection in aquatic animals The present invention provides a preferred method for preventing and/or treating a virus infection in aquatic animals, including the steps of: (i) providing a composition including trichoanguin protein; (ii) adding the composition to an aqueous solution including aquatic animals; and (iii) exposing the aquatic animals to the composition; wherein the ... 07/06/06 - 20060148033 - Cold-induced expression vector A vector having a region encoding a cold shock protein gene mRNA-origin 5′-nontranslated region, characterized in that the 5′-nontranslated region has a mutation having been transferred therein so as to change the distance of the stem structure formed by the region. ... 07/06/06 - 20060148032 - Novel phosphoprotein The present invention relates generally to cancer therapy and cancer diagnostics and to agents useful therefor. More particularly, the present invention provides a novel tumorigenesis-related phosphoprotein and a nucleic acid molecule encoding same. The present invention also provides diagnostic agents to detect the presence or absence of the tumorigenesis-related phosphoprotein ... 07/06/06 - 20060148031 - Hemipteran myosin light chain kinase Novel nucleic acid sequences encoding hemipteran myosin light chain kinases are disclosed. Isolated hemipteran myosin light chain kinases are also disclosed. ... 07/06/06 - 20060148030 - Nuclear receptor err y 3 The present invention relates to novel nuclear receptor ERRγ3. Although ERRγ3 itself lacks a DNA binding domain, it comprises the function of enhancing the transcriptional activation function of arbitrary nuclear receptors, such as ERR, ER, or TR. Moreover, the present inventors found that, like ERRγ3, the known proteins ERRγ1 and ... 07/06/06 - 20060148029 - Lactoferricin gene and transformant expressing lactoferricin Disclosed is a gene encoding a mutated lactoferricin peptide and an E. coli cell transformed with the same, wherein the mutated lactoferricin peptide has substitutions at the 7th and 10th amino acid residues of the wildtype bovine lactoferricin. The gene of the present invention can be expressed in E. coli ... 06/29/06 - 20060141577 - Selection of host cells expressing protein at high levels The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a polypeptide of interest, and for ii) a selectable marker polypeptide functional in a eukaryotic host cell, wherein the polypeptide of interest has a translation initiation sequence separate from that of the selectable marker polypeptide, and ... 06/29/06 - 20060141576 - Variants of corticotropin releasing hormone receptor type 1 and uses thereof The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin ... 06/29/06 - 20060141575 - Secreted proteins and nucleic acids encoding them The invention concerns cDNA molecules encoding TANGO 180, TANGO 181, TANGO 182, TANGO 183, TANGO 184, TANGO 185, TANGO 186, TANGO 187, TANGO 188, TANGO 189, and TANGO 215, all of which are either secreted or transmembrane proteins. The nucleic acids and polypeptides of the present invention are useful as ... 06/29/06 - 20060141574 - Method for producing monoclonal antibodies An improved method for the production of monoclonal antibodies is disclosed. ... 06/29/06 - 20060141573 - Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention ... 06/29/06 - 20060141572 - Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates ... 06/29/06 - 20060141571 - Method for promoting cell growth and increasing the production of the expressed target gene products The present invention is related to a method to promote cell growth, comprising: (a) cloning one or more aspartase coding sequence into a vector to become a recombinant vector, wherein the recombinant vector including a promoter and one or more aspartase coding sequences manipulated to link and insert into the ... 06/29/06 - 20060141570 - Intein-mediated protein purification using in vivo expression of an aggregator protein Purification of recombinant proteins is performed by expressing in a host cell a fusion protein comprising: (a) a product protein domain, (b) an intein, and (c) at least one aggregator protein domain, wherein the aggregator protein domain comprises a protein that is capable of specific association with granules of polyhydroxyalkanoate ... 06/29/06 - 20060141569 - Compositions and methods for the assay of g-protein coupled receptors and their ligands A cell comprising one or more endogenous promiscuous G-proteins and an exogenous nucleic acid sequence that encodes a G-protein coupled receptor (GPCR), which optionally comprises a calcium release activated calcium channel (CRAC channel) provides features and improvements that significantly improve membrane level expression of the GPCR, increase signal responses and ... 06/29/06 - 20060141568 - Modification of collagenous materials and medical treatment, diagnosis and monitoring of fibrotic conditions The present invention relates to the gene PLOD2 which codes for telopeptide lysyl hydroxylase (TLH). This enzyme converts telopeptidyl Lys into telopeptidyl Hyl, that can subsequently be converted into hydroxyallysine cross-links. Collagen with hydroxyallysine cross-links shows a higher resistance to degradation by proteinases than collagen with cross-links derived from allysine. ... 06/29/06 - 20060141567 - Human chemotactic cytokine The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a ... 06/29/06 - 20060141566 - Virus preparations and methods Methods are disclosed for the preparation of herpesvirus, such as herpes simplex virus type 2 for vaccine use. Such viruses can be grown on serum free or serum containing media and can be prepared from the virus containing culture supernatant or virus containing cells. The virus is prepared for subsequent ... 06/29/06 - 20060141565 - Novel fibroblast growth factor and uses thereof The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-22), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof. ... 06/29/06 - 20060141564 - Nucleic acids encoding duramycin Nucleic acids encoding preduramycin and produramycin are described, along with recombinant nucleic acids and host cells containing the same and methods of use thereof, such as for the manufacture of the lantibiotic duramycin. ... 06/29/06 - 20060141563 - Mutant protein and refolding method An FrpB protein having one or more deletions of non-conserved amino acids compared to a corresponding wild-type FrpB protein, and a method of refolding an FrpB protein. ... 06/29/06 - 20060141562 - Mutant e. coli appa phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement. ... 06/29/06 - 20060141561 - Apo-2 ligand/trail variants and uses thereof The disclosure provides Apo-2 ligand variant polypeptides. Methods of making and chemically modifying Apo-2 ligand variant polypeptides are also provided. In addition, formulations of Apo-2 ligand variant polypeptides are provided. In addition, therapeutic methods for using Apo-2 ligand variant polypeptides are provided. ... 06/29/06 - 20060141560 - Estrogen receptor genes and utilization thereof An estrogen receptor gene comprising a nucleotide sequence coding for any of the following amino acid sequences: (a) the amino acid sequence of SEQ ID NO: 1, (b) the amino acid sequence of SEQ ID NO: 4, (c) the amino acid sequence of SEQ ID NO: 23, (d) an amino ... 06/22/06 - 20060134752 - Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member ... 06/22/06 - 20060134751 - Identification of novel ms4a gene family members expressed by hematopoietic cells Isolated nucleic acids encoding MS4A polypeptides, isolated MS4A polypeptides, and uses thereof. The disclosed MS4A nucleic acids and polypeptides can be used to generate a mouse model of atopic disorders, for drug discovery screens, and for therapeutic treatment of atopic disorders or other MS4A-related conditions. ... 06/22/06 - 20060134750 - Method of treatment using interferon-tau Methods of treating an autoimmune condition by administering IFNτ are described. IFNτ is administered orally at a dose sufficient to achieve obtain a desired clinical endpoint, such as a reduction in new contrast-enhanced brain lesions in multiple sclerosis patients. ... 06/22/06 - 20060134749 - Protease, dna encoding the same, and method for manufacturing protease The present invention provides a protease, DNA encoding this protease, a recombinant vector comprising this DNA, and a method for manufacturing the protease using the transformant. ... 06/22/06 - 20060134748 - Orthogonal suppressor trnas and aminoacyl-trna synthetases and uses thereof The present invention provides novel orthogonal suppressor tRNAs, aminoacyl-tRNA synthetases, and suppressor tRNA/aminoacyl-tRNA synthetase pairs. In preferred embodiments the suppressor tRNAs function in mammalian cells and in certain embodiments they are not aminoacylated by any of the mammalian cytoplasmic aminoacyl-tRNA synthetases. The invention provides a novel ochre suppressor tRNA that ... 06/22/06 - 20060134747 - Heterologous alpha amylase expression in aspergillus The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same. ... 06/22/06 - 20060134746 - Adding photoregulated amino acids to the genetic code Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal leucyl-tRNAs, orthogonal leucyl-aminoacyl-tRNA synthetases, and orthogonal pairs of leucyl-tRNAs/synthetases, which incorporate photoregulated amino acids, OMe-L-tyrosine, α-aminocaprylic acid, or o-nitrobenzyl cysteine into proteins are provided in response to an amber selector codon. Methods for identifying these orthogonal pairs ... 06/22/06 - 20060134745 - Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression ... 06/22/06 - 20060134744 - Method and apparatus for the production of soluble mhc antigens and uses thereof The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one method and apparatus for the production of soluble Class I and II HLA molecules. The ... 06/22/06 - 20060134743 - Vectors and methods for enhanced cell longevity and protein expression It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression of P-ank-1 and I2-ank-3 proteins in cell culture has increased ... 06/22/06 - 20060134742 - Production of ggl with low environmental impact A method is disclosed for increasing the specific activity of myo-inositol oxygenase. The method includes incubating a mixture including myo-inositol oxygenase and a non-sulfur containing reductant under conditions effective to increase the specific activity of the myo-inositol oxygenase. Also disclosed are methods for producing D-glucuronic acid and glucurono-γ-lactone comprising incubating ... 06/22/06 - 20060134741 - Composition and methods relating to senp1-a sentrin-specific protease The invention relates to a novel protease, called SENP1, which is active against sentrin-modified proteins in vivo. The invention more specifically relates to the genomic and amino acid sequences for SENP1, compositions related to and based on these sequences, and methods of using these sequences and compositions. ... 06/22/06 - 20060134740 - Engineered proteases for affinity purification and processing of fusion proteins The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention is fused to a second protein to form a protease prodomain fusion protein. The presence of a protease prodomain protein ... 06/22/06 - 20060134739 - Synthesis of proteins by cell-free protein expression In Vitro peptide/protein or biological macromolecule synthesis systems, and methods and kits thereof improve efficiency of in vitro protein or biological macromolecule synthesis and related compositions. ... 06/22/06 - 20060134738 - Gene expression inducing fusion protein and method for controlling gene expression induction The invention relates to a gene expression inducing fusion protein comprising a) a ribonucleic acid linking peptide domain and a post-transcriptional gene expression activator domain and b) a domain enabling cytoplasmic membrane delocalization. The invention also relates to a modulatable permanent external method for controlling gene expression induction by modulating ... 06/15/06 - 20060127984 - Modified vaccinia virus ankara for the vaccination of neonates The invention concern the use of a virus for the preparation of a medicament for the vaccination or treatment of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of ... 06/15/06 - 20060127983 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to ... 06/15/06 - 20060127982 - Development of an asporogenic bacillus licheniformis and production of keratinase therefrom A recombinant bacteria and methods of making and using the same are provided. The recombinant bacteria is a recombinant Bacillus having an inactive endogenous spoIIAC gene, with said recombinant Bacillus producing greater quantities of keratinase than a corresponding wild-type Bacillus that does not have said inactive endogenous spoIIAC gene inserted ... 06/15/06 - 20060127981 - Targeting viruses using a modified sindbis glycoprotein The present invention relates to viruses that are engineered to contain a surface ligand molecule which targets the virus to a cell of interest. In particular non-limiting embodiments, the cell of interest is desirably ablated and may be a cancer cell, an infected cell, a cell exhibiting a non-malignant proliferative ... 06/15/06 - 20060127980 - Human excitatory amino acid transporter-2 gene promoter and uses thereof The nucleic acid sequence of the human Excitatory Amino Acid Transporter-2 Gene (hEAAT2) promoter, a nucleic acid sequence that hybridizes to the hEAAT2 promoter nucleic acid sequence under stringent hybridization conditions, and a nucleic acid sequence that is functionally equivalent to the hEAAT2 promoter sequence are provided, as are vectors ... 06/15/06 - 20060127979 - Chimeric human papillomavirus (hpv) l1 molecules and uses therefor Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing ... 06/15/06 - 20060127978 - Nucleic acid recombination method, host cell and expression vector This invention is to provide a nucleic acid recombination method which enables to carry out precisely homologous recombination of a desired target region, a host cell which enables to carry out precisely homologous recombination of a desired target region, and an expression vector which can be used for the nucleic ... 06/15/06 - 20060127977 - Isolated (t1r2/t1r3) sweet taste receptors that respond to sweet taste stimuli Isolated or biologically pure taste receptors comprised of at least one T1R2 and T1R3 polypeptide and compositions containing are provided. These taste receptors specifically bind and/or are specifically activated by sweet taste stimuli such as natural and artificial sweetener compounds. These taste receptors are useful in screening assays for identifying ... 06/15/06 - 20060127976 - Use of oxalate deficient aspergillus niger strains for producing a polypeptide The invention relates to oxalate deficient A. niger strains for the production of a given enzyme, wherein the oxalate deficient strain produces at least the same amount of enzyme as the wild type strain it originates from under the same culture conditions. Preferably, the oxalate deficient A. niger strain produces ... 06/15/06 - 20060127975 - Method for culturing cells in order to produce substances The invention concerns a method for culturing cells in order to produce substances. According to the invention a cell line producing substances is cultured while feeding a nutrient medium in such a manner that glucose limitation occurs in the culture solution. The degree of glucose limitation DGL=qGlc/qGlcmax (qGlc=observed current specific ... 06/15/06 - 20060127974 - Mpg added to fermentation A method for recovering a protein of interest from a culture solution comprising: adding a polyol having the formula CnH2n+2On, wherein n is from 4 to 8, and/or a carbohydrate, and/or a derivative thereof, to the culture solution during recovery processing. ... 06/15/06 - 20060127973 - Dna sequences of major secreted proteins from the ciliate tetrahymena and use thereof Furthermore a method is disclosed for the heterologous expression of proteins from Tetrahymena using gene constructs made from regulatory elements selected from the group consisting of promoters or terminators from Tetrahymena and coding nucleic acid sequences of a protein to be expressed heterologously, said regulatory elements from Tetrahymena being obtainable ... 06/08/06 - 20060121574 - Recombinant method for making multimeric proteins The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein. ... 06/08/06 - 20060121573 - Production of proteins A method for forming a fusion protein that is expressed as a recombinant protein body-like assembly in host eukaryotic cells and organisms other than higher plants as host systems is disclosed. More particularly, peptides and proteins are fused to protein sequences that mediate the induction of recombinant protein body-like assembly ... 06/08/06 - 20060121572 - Production of heterologous proteins in caulobacter The present invention has identified the Caulobacter RsaFa and RsaFb proteins as the OMP components of the S-layer protein secretion machinery. The present invention has also identified that an enhanced production of a heterologous protein from Caulobacter can be achieved by increased production of RsaFa and/or RsaFb. Expression vectors, genetically ... 06/08/06 - 20060121571 - Lactobacillus acidophilus nucleic acids and uses thereof Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells comprising the expression vectors. Methods for ... 06/08/06 - 20060121570 - Methods for producing polypeptide binding sites, monoclonal antibodies and compositions thereof The present invention describes methods for producing binding sites on polypeptides, and particularly for producing binding sites within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles. The invention also describes oligonucleotides useful for preparing the binding sites, and human ... 06/08/06 - 20060121569 - Production of tnfr-lg An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a ... 06/08/06 - 20060121568 - Production of polypeptides An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a ... 06/08/06 - 20060121567 - Infectious bursal disease virus (ibdv) variant from georgia A VP2 protein isolated from a variant Georgia strain of Infectious Bursal Disease Virus (IBDV) and method of generating such VP2 protein and variant strain for use to reduce or prevent infection in poultry by IBDV. ... 06/08/06 - 20060121566 - Stem cell expansion factor blocking gene limiting hox-induced expansion and method using such factor The present invention relates to a stem cell expansion factor comprising a blocker which reduces expression level of at least one gene normally limiting HOX-induced expansion of stem cells, whereby reducing expression level of said gene enhances expansion of stem cells containing a HOX peptide. The present invention also relates ... 06/08/06 - 20060121565 - Methods for increasing the production of a recombinant polypeptide from a host cell The present invention provides a host cell comprising a nucleic acid sequence encoding a recombinant polypeptide in which the production of a naturally occurring metalloprotease comprising a sequence provided in SEQ ID NO:1 has been reduced or inhibited by genetic manipulation. The present invention also relates to methods for enhancing ... 06/08/06 - 20060121564 - Novel expression vector suitable for expression of recombinant protein at low temperature An inducible expression vector which can express a protein at low temperature and a method for expressing a protein at low temperature using this vector are provided. The inducible expression vector can express a gene encoding a protein whose expression product, inhibits proliferation of the host cell under medium to ... 06/08/06 - 20060121563 - Novel tricistronic vectors and uses therefor A tricistronic vector (i.e., a vector capable of expressing three exogenous genet, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides ... 06/08/06 - 20060121562 - Human receptor tyrosine kinase mertk Reagents that regulate human receptor tyrosine kinase MerTK and reagents which bind to human receptor tyrosine kinase MerTK gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, gastrointestinal and liver disorders, cancer, metabolic disorders (particularly diabetes), neurological disorders, cardiovascular disorders ... 06/08/06 - 20060121561 - Gene for increased somatic recombination The present invention relates to nucleic acids encoding polypeptides involved in homologous recombination, as well as vectors and host cells comprising the nucleic acids and polypeptides encoded by the nucleic acids. Also provided are methods for inducing somatic and/or meiotic homologous recombination in a cell, comprising modulating the expression or ... 06/01/06 - 20060115877 - Hyaluronate synthase gene and uses thereof Disclosed are DNA sequences encoding hyaluronic acid synthase that are employed to construct recombinant cells useful in the production of hyaluronata synthase and hyaluronic acid (HA). In preferred aspects, chromosomal DNA encoding the HA synthase gene, hasA, was cloned from a Streptococcus pyoganas genomic library. These vectors were used to ... 06/01/06 - 20060115876 - Site-directed modification of fviii This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. ... 06/01/06 - 20060115875 - Detection, characterization and treatment of viral infection and methods thereof A method of detecting, characterizing and treating viral infection is provided. In particular, a strategy of molecular mimicry is provided for characterizing viral behavior and/or a predisposition for a given viral outcome in vivo. Novel compositions are also provided for detecting, characterizing and treating viral infections. ... 06/01/06 - 20060115874 - Enrichment method for variant proteins with altered binding properties A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous ... 05/25/06 - 20060110800 - Testis-specific receptor Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and ... 05/25/06 - 20060110799 - Mitogen-activated protein kinase kinase mek6 and methods of use thereof Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and ... 05/25/06 - 20060110798 - Cells expressing recombinase useful for adenovirus vector production and control of gene expression Embodiments of the invention provide cells that stably express an integrase family recombinase, for example Cre or FLP. Examples of production of such cells, and uses of such cells, are provided. In some embodiments, a cell may additionally express one or more adenovirus E1 proteins. In some embodiments, the cell ... 05/25/06 - 20060110797 - Polypeptides having xyloglucanase activity and nucleic acids encoding same The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. ... 05/25/06 - 20060110796 - In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars. ... 05/25/06 - 20060110795 - Protein secretion in eukaryotic cells The present invention relates to the use of a glucosidase II mutation to increase protein secretion in eukaryotic cells. The present invention relates further to the use of eukaryotic cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant α-1,2-mannosidase gene and/or a recombinant ... 05/25/06 - 20060110794 - Peptides from the e2 proteins of human papillomaviruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are ... 05/25/06 - 20060110793 - Methods and compositions for increasing longevity and protein yield from a cell culture Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. By transfecting cells in culture with an apoptosis-inhibiting gene or vector, cells in culture ... 05/25/06 - 20060110792 - Potassium channels, nucleotide sequences encoding them, and methods of using same This invention relates generally to a new family of potassium channels. More particularly, the present invention relates to the cloning and characterization of a family of distinct trans-membrane potassium ion channels, characterization of such channels, newly identified polynucleotide sequences, polypeptides encoded by such sequences, expression vectors capable of heterologous expression ... 05/25/06 - 20060110791 - Heterologus expression of trypanothione reductase from leishmania donovani in a prokaryotic system The present invention relates to a process for heterologous expression and large-scale production of functionally active enzyme trypanothione reductase of Leishmania donovani in prokaryotic system. ... 05/25/06 - 20060110790 - Expression system for large functional proteins The present invention provides a system and method for expressing functional ABC (ATP-binding cassette) proteins, from the ABCA subfamily, in a host cell. A system comprises two or more expression vectors each comprising a nucleic acid molecule encoding one or more domains of an ABC transporter gene and a means ... 05/25/06 - 20060110789 - Methods to mediate polyketide synthase module effectiveness Linking sequence which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides. The modules are provided suitable linkers so that the polyketide chain is passed ... 05/18/06 - 20060105428 - Alkaline protease The present invention relates to genes expressing an alkaline protease having a prepro sequence, vectors containing the same, and transformants containing said vector. The present invention also relates to a method for producing an alkaline protease. ... 05/18/06 - 20060105427 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to ... 05/18/06 - 20060105426 - Mcfp encoding nucleic acids, polypeptides, antibodies and methods of use thereof mcFP encoding nucleic acids, polypeptides and antibodies immunologically specific therefore are disclosed. Methods of use thereof are also provided. ... 05/18/06 - 20060105425 - Aspergillus niger promoter for expressing genes in host cells The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same. ... 05/18/06 - 20060105424 - Process for production of cephalosporin c The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium chrysogenum host cells which have been transformed with such a vector and to a method for production of cephalosporin C using ... 05/18/06 - 20060105423 - Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors The invention relates to a microorganism with a nucleotide sequence coding for a cell antigen in which the following components are inserted and are expressible: I) a nucleotide sequence coding for at least one epitope of an antigen of a tumor cell and/or a nucleotide sequence for at least one ... 05/11/06 - 20060099688 - Udp-galactose: beta-d-galactose-r4-alpha-d-galactosyltransferase, alpha4gal-t1 A novel gene defining a novel enzyme UDP-galactose: β-D-galactose-R 4-α-D-galactosyltransferase, termed α4Gal-T1, with unique enzymatic properties is disclosed. The invention provides isolated DNA molecules and DNA constructs encoding α4Gal-T1 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting α4Gal-T1 activity, as well as cloning and expression ... 05/11/06 - 20060099687 - 14926 receptor, a novel g-protein coupled receptor The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further ... 05/11/06 - 20060099686 - Generation of artificial binding proteins on the basis of ubiquitin proteins The invention relates to modified proteins of the superfamily of “ubiguitin-like proteins”, proteins that have a ubiguitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention ... 05/11/06 - 20060099685 - Recombinant expression of factor viii in human cells The invention discloses a process for recombinant production of blood coagulation Factor VIII in an immortalized human embryonic retina cell, said cell expressing at least an adenoviral E1A protein and comprising a nucleic acid sequence encoding said Factor VIII, said nucleic acid sequence being under control of a heterologous promoter, ... 05/11/06 - 20060099684 - Novel antiangiogenic peptides The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1, or a fragment thereof, which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the fragment has at least 50% inhibition of bFGF-stimulated EC ... 05/11/06 - 20060099683 - Isolated hoat polypeptide This invention is concerned with human organic anion transporter (“hOAT”). Isolated nucleic acid encoding hOAT is provided, along with ioslated hOAT polypeptide. hOAT nucleic acid and/or hOAT polypeptide are employed in transgenic animals, recombinant cells, replicable vectors and analytical procedures for identifying hOAT agonists or antagonists, assays for identifying hOAT ... 05/11/06 - 20060099682 - Human vanilloid receptors and their uses The invention provides novel human vanilloid receptor (hVR) proteins, in particular hVR1 and hVR3, nucleotide sequences encoding for the novel hVR proteins, and hVR proteins for use in a method for screening for agents useful in the treatment or prophylaxis of disorders which are responsive to modulation of hVR activity ... 05/11/06 - 20060099681 - Human and mouse alkaline ceramidase 1 and skin diseases Newly discovered, isolated, and cloned human alkaline ceramidase 1 (haCER1) and mouse alkaline ceramidase 1 (maCER1) are provided, which are predominantly expressed in skin cells and hydrolyze D-erthyro-ceramide exclusively. ... 05/11/06 - 20060099680 - Yeast transformant into which genes associated with synthesis system of o-fucosylated protein are introduced An object of the present invention is to provide a means for producing O-fucosylated protein in large quantities, a means for searching for new genes associated with the synthesis system of O-fucosylated protein or the proteins expressed by the genes, and a means for elucidating the functions thereof. According to ... 05/11/06 - 20060099679 - Methods for engineering polypeptide variants via somatic hypermutation and polypeptides made thereby Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising ... 05/11/06 - 20060099678 - Method of inducing homologous recombination of somatic cell The present invention provides a method for obtaining diverse novel genes by inducing somatic cell homologous recombination at genetic loci in somatic cells. By controlling transcription activity of a gene that exists at a genetic locus in a eukaryotic organism cell wherein DNA homologous recombination is occurring at an arbitrary ... 05/11/06 - 20060099677 - Dna/rna transduction technology and its clinical and basic applications This invention relates to a method for in vivo and in vitro transferring efficiently DNA/RNA coding materials regulating bio-function to cytoplasm or nucleus in eukaryotic or prokaryotic cells using PTD (Protein Transduction Domain) and DNA/RNA binding factor. Particularly, this invention provides a method for in vivo transferring the materials to ... 05/11/06 - 20060099676 - Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes The invention provides nucleotide sequence of a novel mammalian gene, the RapR6 gene, which is involved in resistance and tumorgenesis, and amino acid sequences of the encoded proteins. The present invention also provides methods and compositions for regulating rapamycin resistance and/or tumorgenesis by modulating the expression and/or the activity of ... 05/11/06 - 20060099675 - Method for preparing an extracellular matrix and its use for tumor cell culture The invention concerns a method for preparing an isolated extracellular matrix, secreted by tumor cells, in particular epitheliomatous cells, methods for tumor cell culture using such a matrix, the use of such a matrix for producing a tumor cell line as well as novel tumor cell lines obtained by said ... 05/11/06 - 20060099674 - Chromatographic purification of recombinant human erythropoietin The invention provides a method for recovering and purifying recombinant human erythropoietin (rhEpo) from a cell culture medium comprising host cells, which method comprises the steps of: (a) removing host cells, cellular constituents and debris from the cell culture medium by centrifugation using a disc stack separator followed by a ... 05/11/06 - 20060099673 - Novel recombinant gene expression method by stop codon suppression This invention describes a novel recombinant gene expression method based on a novel recombinant gene expression vector, comprising in the following order a promoter sequence, a gene of interest, a translational stop signal and translationally linked to said gene of interest a selectable marker gene. ... 05/04/06 - 20060094082 - Composition of lactoferrin related peptides and uses thereof The present invention is directed to a composition consisting of a series of novel biologically active 33-mer peptides. ... 05/04/06 - 20060094081 - Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization The present invention includes a crystal structure of the kinase domain of c-fms and a methodology to produce diffraction quality crystals of the c-fms kinase domain by heterologous substitution of the kinase insert domain. Also included in the invention is the structure of the c-fms kinase domain in liganded form ... 05/04/06 - 20060094080 - Trichoderma reesei glucoamylase and homologs thereof The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences, ... 05/04/06 - 20060094079 - Protein for blocking platelet adhesion A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The ... 05/04/06 - 20060094078 - Method of improving the production of biomass or a desired product from a cell The production of biomass or a desired product from a cell can be improved by inducing conversion of ATP to ADP without primary effects on other cellular metabolites or functions which is achieved by expressing an uncoupled ATPase activity in said cell and incubating the cell with a suitable substrate ... 04/27/06 - 20060088916 - Il-17 homologous polypeptides and therapeutic uses thereof The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/27/06 - 20060088915 - Novel physiologically active peptide and use thereof The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity ... 04/27/06 - 20060088914 - Ucp5 The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous ... 04/27/06 - 20060088913 - Mutation associated with epilepsy An isolated mammalian DNA molecule encoding a mutant γ-aminobutyric acid type A (GABAA) receptor subunit, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled GABAA receptor, or an otherwise functional fragment ... 04/27/06 - 20060088912 - Compositions and methods of purifying myelin-associated glycoprotein (mag) The present invention provides compositions and methods useful for purifying recombinant myelin-associated glycoprotein (MAG) and fragments thereof. In particular, the invention provides a one-step purification method for MAG and MAG fragments. Novel forms of human recombinant MAG protein are also disclosed in addition to methods of reliably producing and storing ... 04/27/06 - 20060088911 - Yeast transformation system Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein. ... 04/27/06 - 20060088910 - Rt-pcr-based cloning of the human beta-amyloid precursor protein gene and the construction of its expression plasmids Beta-amyloid peptide (βA) is a major fibrillar component of neuritic plaques in Alzheimer's disease brains and is related to the pathogenesis of the disease. βA generation depends on proteolytic cleavage of the amyloid precursor protein (APP). The present invention is a new procedure for the cloning of human βA precursor ... 04/27/06 - 20060088909 - Virus-like particles, methods of preparation, and immunogenic compositions Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of liciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core ... 04/27/06 - 20060088908 - Mutiens of human neutrophil gelatinase-associated lipocalin and related proteins Disclosed is a method for generating a mutein of a protein selected from the group consisting of human neutrophil gelatinase-associated lipocalin (hN-GAL), rat α2-microglobulin-related protein (A2m) and mouse 24p3/uterocalin (24p3), said mutein having detectable affinity to a given target. The method comprises the step of subjecting the protein to mutagenesis ... 04/27/06 - 20060088907 - Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, ... 04/20/06 - 20060084147 - Apo-2 receptor Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided. ... 04/20/06 - 20060084146 - Method for cell-free protein synthesis using extract solution derived from insect cell The present invention provides a simple cell-free protein synthesis method capable of affording synthesis of a protein in a high amount in a short time at a low cost. A method for cell-free protein synthesis using an extract derived from an insect cell, the method comprising removing a component which ... 04/20/06 - 20060084145 - Srage mimetibody, compositions, methods and uses Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed. ... 04/20/06 - 20060084144 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/20/06 - 20060084143 - Tweak receptor The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac ... 04/20/06 - 20060084142 - Activating mutations of platelet derived growth factor receptor alpha (pdgfra) as diagnostic markers and therapeutics targets This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules ... 04/20/06 - 20060084141 - Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin The present invention relates to compositions and methods involving antitumor agents derived from bacteria. In particular, the present invention provides the ansamitocin biosynthetic gene cluster for the production of novel maytansinoid analogs with potent antitumor activity and reduced human toxicity. ... 04/20/06 - 20060084140 - Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39 The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention ... 04/20/06 - 20060084139 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/20/06 - 20060084138 - The pro4979 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/13/06 - 20060078968 - Sequence specific dna recombination in eukaryotic cells The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence ... 04/13/06 - 20060078967 - Antibodies for il-17 receptor like polypeptides and uses thereof The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of ... 04/13/06 - 20060078966 - Il-17 receptor like polypeptides and uses thereof The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of ... 04/13/06 - 20060078965 - Chinese hamster ovary cell line transfected with 30k gene The present invention relates to a CHO (Chinese hamster ovary) cell line transfected with 30 K gene. More particularly, the present invention is directed to a CHO cell line transfected with 30 K genes obtained from the silkworm Bombyx Mori, which has anti-apoptotic property. ... 04/13/06 - 20060078964 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073570 - Apo-2 receptor Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided. ... 04/06/06 - 20060073569 - Von willebrand factor (vwf) - cleaving protease This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain ... 04/06/06 - 20060073568 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073567 - Novel insulin/igf/relaxin family polypeptides and dnas thereof The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by ... 04/06/06 - 20060073566 - Active modified hedgehog proteins The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly ... 04/06/06 - 20060073565 - Novel nucleic acid molecules encoding opioid growth factor receptors This invention relates to novel nucleic acid molecules coding for opioid growth factor receptors. In particular, the present invention provides isolated nucleic acid molecules coding for human and rat OGF receptors. Antisense molecules, expression vectors and host cells, isolated proteins encoded by such nucleic acid molecules, antibodies directed against such ... 04/06/06 - 20060073564 - Nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (apeced) The present invention relates to a nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). In addition, the invention relates to a mammalian, preferably murine, homologue of the above nucleic acid molecule. The present invention further relates to a nucleic acid molecule ... 04/06/06 - 20060073563 - Erythropoietin derivatives with altered immunogenicity The present invention relates to novel erythropoietin protein variants with altered immunogenicity. ... 04/06/06 - 20060073562 - Protein tyrosine kinase substrate lat and its use in the indentification of (ant)agonists of the kinase The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their ... 04/06/06 - 20060073561 - 157 human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, ... 04/06/06 - 20060073560 - Selective expression in filamentous fungi Gene promoters activated only during development of the fruiting body of filamentous fungi permit expression of large quantities of heterologous genes, even where such are otherwise toxic to the organism. ... 04/06/06 - 20060073559 - Ehanced protein expression in bacillus The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and ... 04/06/06 - 20060073558 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073557 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073556 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073555 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073554 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073553 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073552 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073551 - Pro4487 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073550 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073549 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073548 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073547 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073546 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 04/06/06 - 20060073545 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hostcells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of ... 04/06/06 - 20060073544 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 03/30/06 - 20060068472 - Compositions to ameliorate protein misfolding and aggregation The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of torsin activity, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which encode polypeptides having varying degrees ... 03/30/06 - 20060068471 - Soluble zcytor 11 cytokine receptors Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding ... 03/30/06 - 20060068470 - Antifreeze proteins from basidiomy cetes The present invention provides antifreeze proteins produced by a basidiomycete. The antifreeze protein has a high antifreeze activity such as a thermal hysteresis activity or an ice-recrystallization inhibition activity. ... 03/30/06 - 20060068469 - Bacterial vector systems The present invention provides bacterial vectors and fusion proteins containing a TTSS polypeptide, compositions of such fusion proteins including polynucleotides, and methods of delivering one or more genes into a target cell that involve contacting the cell with a composition that includes such a fusion protein. Compositions and methods of ... 03/30/06 - 20060068468 - Actrii receptor polypeptides, methods and compositions In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and ... 03/30/06 - 20060068467 - Rhodococcus nitrile hydratase The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in ... 03/30/06 - 20060068466 - Novel g protein-coupled receptor The present invention is directed to novel G protein-coupled receptors that are found predominantly in the dorsal root ganglia. The invention encompasses both the receptor proteins as well as nucleic acids encoding the proteins. In addition, the present invention is directed to methods and compositions which utilize the receptors. ... 03/30/06 - 20060068465 - Ubiquitin-specific protease occurring in the brain and dna encoding the same A ubiquitin-specific protease occurring in the brain and a DNA encoding it, which are useful for research on the molecular mechanism of the neuroplasticity expression and so on. ... 03/30/06 - 20060068464 - Regulation of human g protein coupled receptor Reagents which regulate human G protein-coupled receptor and reagents which bind to human GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, ... 03/30/06 - 20060068463 - Natural killer cell activating factor ii The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to ... 03/23/06 - 20060063234 - Efficient production of igm in recombinant mammalian cells Described is an immortalized human retina cell expressing E1A and E1B proteins of an adenovirus, wherein the cell includes recombinant nucleic acid encoding an IgM molecule in expressible format. Also described are methods for recombinant production of an IgM molecule, such methods including culturing a cell of the invention and ... 03/23/06 - 20060063233 - Cytokine protein family The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral ... 03/23/06 - 20060063232 - Host-vector system for antibiotic-free coie1 plasmid propagation A host-vector system that uses the RNA-based copy number control mechanism of ColE1-type plasmids for regulating the expression of a marker gene allows for antibiotic-free selection of plasmids and is useful for production of plasmid DNA and recombinant proteins. ... 03/23/06 - 20060063231 - Compositions and methods for protein production Disclosed herein are methods and compositions for enhanced protein production and overexpression using engineered zinc finger proteins. ... 03/23/06 - 20060063230 - Sulfatases and methods of use thereof Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of ... 03/23/06 - 20060063229 - Mmfp encoding nucleic acids, polypeptides, antibodies and methods of use thereof mmFP encoding nucleic acids, polypeptides and antibodies immunologically specific therefor are disclosed. Methods of use thereof are also provided. ... 03/23/06 - 20060063228 - Antibodies against human interleukin-13 and uses therefor This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or ... 03/23/06 - 20060063227 - Secreted proteins and polynucleotides encoding them Novel polynucleotides and the proteins encoded thereby are disclosed. ... 03/16/06 - 20060057677 - Organic anion transporter and gene coding for the same A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The protein and gene therefor are ... 03/16/06 - 20060057676 - Compositions and methods using the yeast ylr110c promoter The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon source, such as ethanol, or both. Therefore, expression of nucleic acid molecules ... 03/16/06 - 20060057675 - Human toll homologue The invention relates to the identification and isolation of novel DNAs encoding the human Toll protein PRO358 and its variants, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO358. ... 03/16/06 - 20060057674 - Translocating enzyme as a selection marker The subject of the present invention is a selection system for microorganisms, which is based on the inactivation of an essential translocating enzyme and the curing of this inactivation by means of an indentically acting factor which is made available to the cells concerned by means of a vector. One ... 03/16/06 - 20060057673 - Epitope analogs Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which ... 03/16/06 - 20060057672 - Exo-endo cellulase fusion protein The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo ... 03/16/06 - 20060057671 - Immobilized probes and methods of detecting conformationally altered prion proteins The present invention provides methods of making immobilized probes that are specific for prion proteins, methods of using such probes to bind, detect, and remove prion proteins from samples, and kits for practicing the invention. The invention discloses immobilized probes that are locked into a particular, pre-determined configuration and that ... 03/16/06 - 20060057670 - Genomic markers of hepatitis b virus associated with hepatocellular carcinomas The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). ... 03/16/06 - 20060057669 - Inactive transcription factor tif-ia and uses thereof Inactive transcription factor TIF-IA and uses thereof. Described are inactive forms of the human transcription initiation factor TIF-IA, preferably a mutant form of TIF-IA which lacks functionally important posttranslational modifications, e.g. phosphorylation, acetylation, glycosylation etc. Moreover, nucleic acid molecules encoding said TIF-IA are described as well as recombinant vectors containing ... 03/16/06 - 20060057668 - Antimicrobial polypeptide and utilization thereof The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences ... 03/16/06 - 20060057667 - Isolated human transporter proteins nucleic acid molecules encoding human transporter proteins and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying ... 03/16/06 - 20060057666 - Human g protein coupled receptor The invention provides isolated nucleic acids that encode GPCR-A-1, and fragments thereof, vectors for propagating and expressing GPCR-A-1 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel GPCR-A-1 isoforms, and antibodies thereto. The invention further provides ... 03/16/06 - 20060057665 - Galectin-14 therapeutic molecule and uses thereof The present invention relates generally to a novel galectin and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof capable of modulating an immune response and, in particularly, an inflammatory response. More particularly, the present invention relates to ecalectin-like galectin (herein referred to as “galectin-14”) and to derivatives, homologues, analogues, ... 03/16/06 - 20060057664 - Polypeptides and polynucleotides encoding same The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection, ... 03/16/06 - 20060057663 - Novel g protein-coupled receptor protein and dna thereof The present invention provides a human-derived protein or a salt thereof, a DNA encoding the same, a method for determination of ligand to the protein, a screening method/kits for a compound or its salt that alters a binding property between ligand and the protein, and the like. The human-derived protein ... 03/16/06 - 20060057662 - Membrane scaffold proteins Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their ... 03/09/06 - 20060051843 - Novel fluorescent proteins A GFP with an F64L mutation and an E222G mutation is provided. This GFP has a bigger Stokes shift compared to other GFPs making it very suitable for high throughput screening due to a better resolution. This GFP also has an excitation maximum between the yellow GFP and the cyan ... 03/09/06 - 20060051842 - Nucleic acid encoding alpha chain of human il-11 receptor The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof ... 03/09/06 - 20060051841 - Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase a2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities Isolated novel and purified and characterized phospholipase A2, referred to herein as calcium-independent phospholipase A2zeta (iPLA2zeta) having SEQ. ID. NO: 2 (See FIG. 1), and nucleic acid sequence (SEQ. ID. NO: 4), and calcium-independent phospholipase A2eta (iPLA2eta) having SEQ. ID. NO: 3 (See FIG. 1), and nucleic acid sequences (SEQ. ... 03/09/06 - 20060051840 - Hybrid expression of neisserial proteins Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH. ... 03/09/06 - 20060051839 - Dna expression vectors and methods of use The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, ... 03/09/06 - 20060051838 - Genetic computing using combinatorial transcription control A scheme is provided for selecting the regulatory DNA sequences to exert combinatorial control of gene transcription in vivo by multiple regulatory proteins, i.e., transcription factors (TFs). The method provides the ability to implement a wide range of complex logic functions through the manipulation of the regulatory DNA sequences, typically ... 03/09/06 - 20060051837 - Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides ... 03/09/06 - 20060051836 - Molecules for disease detection and treatment Various embodiments of the invention provide human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ... 03/09/06 - 20060051835 - Pael receptor, cells and animal expressing pael receptor and method of screning remedy for parkinson's disease An object of the present invention is to provide a substrate of Parkin, a system for elucidating the cause of Parkinson's disease using the substrate and a method of screening for a remedy for Parkinson's disease. An animal cell having a DNA encoding a human Pael receptor or a DNA ... 03/02/06 - 20060046284 - Bgl4 beta-glucosidase and nucleic acids encoding the same The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same. ... 03/02/06 - 20060046283 - Dna encoding anti-apoptotic protein and recombinant 30k protein The present invention relates to DNAs encoding anti-apoptotic 30K proteins. More particularly, the present invention is directed to 30K protein genes and a recombinant proteins prepared by using novel anti-apoptotic gene obtained from silkworm. The present invention also provides anti-apoptotic health care food, pharmaceutical preparation, additive for cell culture medium, ... 02/23/06 - 20060040360 - Adipocyte complement related protein homolog zacrp7 The present invention relates to polynucleotide and polypeptide molecules for zacrp7, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in homo and heterotrimerization or oligomerization and may be used in the study thereof. The ... 02/23/06 - 20060040359 - Oxidation-reduction sensitive green fluorescent protein variants The disclosure provides proteins that can be used to determine the redox status of an environment (such as the environment within a cell or subcellular compartment). These proteins are green fluorescent protein (GFP) variants (also referred to as redox sensitive GFP (rosGFP) mutants), which have been engineered to have two ... 02/23/06 - 20060040358 - Igf-1 receptor interacting proteins The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide. ... 02/23/06 - 20060040357 - Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the ... 02/23/06 - 20060040356 - Methods of using a mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials ... 02/23/06 - 20060040355 - Mutated tn5 transposase proteins and the use thereof Transposase proteins that are modified relative to and have higher transposase activities than the wild-type Tn5 transposase are disclosed. A transposase protein of the present invention differs from the wild-type Tn5 transposase at amino acid position 41, 42, 450, or 454 and has greater avidity than the wild-type Tn5 transposase ... 02/23/06 - 20060040354 - Novel polyadenylation signal for use in expression vectors Disclosed are novel polynucleotides and expression vectors which comprise an immunoglobulin gene polyadenylation signal and a DNA sequence encoding a polypeptide wherein the DNA sequence is other than a genomic DNA sequence from the immunoglobulin gene. Also, disclosed is a eukaryotic cell or cell-line comprising the novel expression vectors and ... 02/23/06 - 20060040353 - Production of galactosylated glycoproteins in lower eukaryotes The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in ... 02/23/06 - 20060040352 - Expression of mammalian proteins in pseudomonas fluorescens The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances Processes for improved ... 02/23/06 - 20060040351 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 02/23/06 - 20060040350 - Novel glutamate receptors and utilization thereof The inventive subject matter relates to novel glutamate receptors and utilization thereof; more specifically to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method ... 02/23/06 - 20060040349 - Thermophilic hydrophobin proteins and applications for surface modification The present invention relates to a thermophilic hydrophobin, TT1, or a protein or polypeptide substantially similar thereto, derived from the thermophilic fungus Talaromyces thermophilus. The invention further relates to a polynucleotide encoding such hydrophobin, as well as to materials coated with such hydrophobin. ... 02/23/06 - 20060040348 - Methods for producing and purifying recombinant alpha-l-iduronidase The present invention provides a recombinant human α-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human α-L-iduronidase enzyme thereof. ... 02/23/06 - 20060040347 - Use of triplex structure dna in transferring nucleotide sequences The invention concerns a recombinant vector characterised in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), said regions being of retroviral or retroviral-like origin, said vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and retranscription ... 02/23/06 - 20060040346 - Bacillus host cell A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more polypeptide(s) involved in antibiotic synthesis which is at least 80% identical to one or more of the polypeptides shown in SEQ ... 02/16/06 - 20060035338 - Method and apparatus for the production of soluble mhc antigens and uses thereof The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one method and apparatus for the production of soluble Class I and II HLA molecules. The ... 02/16/06 - 20060035337 - Leukocyte adhesion inhibitor-1 (lai-1) There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1 (CKα1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and ... 02/16/06 - 20060035336 - Prokaryotic collagen-like proteins and uses thereof The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host ... 02/16/06 - 20060035335 - Use of hcv proteins A Hepatitis C virus (HCV) protein such as a non-structured protein 4 (NS4) or a non-structured protein 3 (NS3) or a derivative or fragment or variant or peptide thereof or product of cells activated by the agent is useful in the treatment and/or prophylaxis of an inflammatory and/or an immune-mediated ... 02/16/06 - 20060035334 - Apo-2 receptor Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided. ... 02/16/06 - 20060035333 - Methods and compositions for concentrating secreted recombinant protein Methods and compositions are described that relate to obtaining concentrated preparations of secreted recombinant proteins. These proteins are expressed in the form of fusion proteins with a chitin-binding domain (CBD). The fusion proteins are capable of being concentrated in the presence of chitin. Also described is: a shuttle vector that ... 02/16/06 - 20060035332 - Novel rfrp-3 and dna thereof The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism. ... 02/16/06 - 20060035331 - G-protein coupled receptors The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC. ... 02/16/06 - 20060035330 - Non aggregating fluorescent proteins and methods for using the same Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the the non-aggregating feature arises from the modulation of residues in the N-terminus of the protein ... 02/16/06 - 20060035329 - Human hairless gene and protein The novel nucleotide sequence and deduced amino acid sequence of the human Hairless gene and protein, respectively, are disclosed. A Hairless expression construct may be used in transcription assays. Moreover, processes of making and using the aforementioned products in screening assays which affect Hairless-regulated transcription are disclosed. Kits comprising a ... 02/16/06 - 20060035328 - Artery-and vein-specific proteins and uses therefor Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a ... 02/16/06 - 20060035327 - Recombinant super-compound interferon and uses thereof This invention provides a recombinant super-compound interferon (rSIFN-co) and its equivalent with changed spatial configuration, high efficacy and low side effects. Therefore, high dose of rSIFN-co may be used. One characteristic of rSIFN-co is its ability to inhibit the HBV DNA duplication and secretion of HBsAg and HBeAg in in ... 02/16/06 - 20060035326 - Genes The present invention relates to two primordial germ cell-specific expressed genes, Fragilis and Stella. The sequences and sues of human Stella and Fragilis are disclosed herein, as are several mouse sequences related to Fragilis. The present invention relates to the use of Stella and Fragilis as markers for primordial germ ... 02/16/06 - 20060035325 - Regulated apoptosis We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells. ... 02/16/06 - 20060035324 - Basb019 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... 02/16/06 - 20060035323 - Method for producing sweetners and alcohol The present invention relates to variants of a parent α-amylase, which parent α-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least ... 02/16/06 - 20060035322 - T-cell epitopes in erythropoietin The invention relates to the identification of epitopes for T-cells in human EPO as well as T-cell epitope peptides derived from EPO by means of which it is possible to create novel modified EPO variants with reduced immunogenicity. ... 02/16/06 - 20060035321 - Hydantoin racemase The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least 87% idcntity with SEQ ID: NO. 2 or SEQ ED: NO. 4. The invention also relates to nucleic acid sequences encoding these polypeptides. ... 02/16/06 - 20060035320 - Immunoglobulin frameworks which demonstrate enhanced statbility in the intracellular envioronment and methods of identifying same Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and ... 02/16/06 - 20060035319 - Chimaeric human papillomavirus 16 l1 virus like particles and a method for preparing the particles The invention describes a method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide. The method comprises the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for the L1 polypeptide; introducing ... 02/16/06 - 20060035318 - Teneurin c-terminal associated peptides (tcap) and uses thereof The invention provides a novel family of biologically active neuropeptides and the nucleic aid molecules coding for same. The peptides are derived for the C-terminus of the teneurin family peptides (Ten M1-4). These novel peptides, referred to as teneurin C-terminal associated peptides (TCAPs) are active in neuronal communication and are ... 02/16/06 - 20060035317 - Effect of treatment with 4,5-dihydroxy-2-cyclopenten-1-one (dhcp) on gene expression and quorum-sensing in bacteria DHCP (4,5-dihydroxy-2-cyclopenten-1-one) has been previously shown to have antibacterial activity against Escherichia coli. Global transcriptional pattern of E. coli was analyzed in response to DHCP by DNA microarray. It is now shown that DHCP has widespread effects in E. coli, affecting genes encoding proteins involved in general metabolism and cell ... 02/16/06 - 20060035316 - Plasmids expressing human insulin and the preparation method for human insuling thereby The present invention relates to human insulin expression plasmids and a method for producing insulin using the same. The plasmids comprise a sequence encoding a compound of the formula R—B—X-A, in which R is a leader peptide of the formula of Met-Thr-Met-Ile-Thr-Y (SEQ ID NO: 36), in which Y is ... 02/16/06 - 20060035315 - Transporters and ion channels The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH. ... 02/16/06 - 20060035314 - Receptors and signalling proteins capable of binding meiotic acting sterols (mas) Proteins capable of binding meiosis activating sterols (MAS), designated SAM1a and SAM1b, and useful in methods for assaying MAS receptor ligands, agonists and antagonists, as well as DNA sequences encoding such proteins. ... 02/09/06 - 20060030005 - C3b/c4b complement receptor-like molecules and uses thereof Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides. ... 02/09/06 - 20060030004 - Brain natriuretic peptide Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis. ... 02/09/06 - 20060030003 - Composition and method for introduction of rna interference sequences into targeted cells and tissues A composition and method are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by ... 02/09/06 - 20060030002 - Isoforms of the human vitamin d receptor The invention provides isolated polynucleotide molecules which encode novel isoforms of the human Vitamin D receptor (hVDR) or variant transcripts for hVDR. These isolated polynucleotide molecules may be utilised in, for example, methods of screening compounds for VDR agonist and/or antagonist activities. ... 02/09/06 - 20060030001 - Useful polypeptides The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the ... 02/09/06 - 20060030000 - Growth factor binding constructs materials and methods The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial growth factors, platelet derived growth factors, and other ligands are provided. ... 02/09/06 - 20060029999 - Nucleic acid sequences having an activity of regulating translation efficiency and utilization thereof The present invention provides a polynucleotide comprising a nucleic acid sequence having an activity of regulating the translation efficiency of a template in a cell-free protein synthesis system and also provides a method for utilizing the same, etc. Protein synthesis is carried out by a translation template containing a polynucleotide ... 02/09/06 - 20060029998 - Human semaphorin l (h-semal) and corresponding semaphorins in other species The invention relates to novel semaphorins which are distinguished by a particular domain structure and derivatives thereof, nucleic acids (DNA, RNA, cDNA) which code for these semaphorins, and derivatives thereof, and the use thereof. The present invention relates to semaphorins which have a novel, as yet undisclosed and unexpected domain ... 02/09/06 - 20060029997 - Cloning and expression of recombinant adhesive protein mefp-1 of the blue mussel, mytilus edulis The present invention comprises a Mytilus edulis cDNA sequenc having a nucleotide sequence that encodes for the Mytilus edulis foot protein-1 (Mefp-1), an example of a mollusk foot protein. Mefp-1 is an integral component of the blue mussels' adhesive protein complex, which allows the mussel to attach to objects underwater. ... 02/09/06 - 20060029996 - Cloning and expression of recombinant adhesive protein mefp-2 of the blue mussel, mytilus edulis The present invention includes a Mytilus edulis cDNA having a nucleotide sequence that encodes for the Mytilus edulis foot protein-2 (Mefp-2), an example of a mollusk foot protein. Mefp-2 is an integral component of the blue mussels' adhesive protein complex, which allows the mussel to attach to objects underwater. The ... 02/02/06 - 20060024792 - G-protein coupled receptors The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC. ... 02/02/06 - 20060024791 - Method The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N— or C-terminus with one or more marker moieties and arrays containing such proteins, as well as the use of ... 02/02/06 - 20060024790 - Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant dna Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino acid such as lysine or a ... 02/02/06 - 20060024789 - Lipase from geobacillus sp. strain t1 A biologically pure culture of Geobacillus Strain T1 bacteria isolated from Palm Oil Mill Effluent capable of producing thermostable lipase T1 gene. The production of thermostable lipase T1 gene from a novel Geobacillus bacterium having a designated as strain T1, was aerobic, gram positive and endospore-forming, rod-shaped. The G+C content ... 02/02/06 - 20060024788 - Inducible alphaviral gene expression system The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising nucleotide sequences that are transcribed to form RNA molecules which are then replicated by a temperature-sensitive replicase to form additional RNA molecules. The RNA molecules ... 02/02/06 - 20060024787 - Chimp trace amine associated receptors and polypeptides The present invention provides a fingerprint sequence which is specific and selective for chimp trace amine associated receptors (TAAR) forming a subfamily of G protein coupled receptors. The invention also provides the novel chimp polypeptides identified as members of this family, nucleic acids encoding said polypeptides, and vectors and host ... 02/02/06 - 20060024786 - Wasp and n-wasp constructs and methods of expressing such constructs WASP and N-WASP proteins are provided that can be expressed in soluble form, including fusion proteins that contain full-length WASP and N-WASP. The proteins retain at least partial activity of full length WASP or N-WASP and some of the proteins fully recapitulate the activity of full-length WASP and N-WASP. Methods ... 02/02/06 - 20060024785 - Variants of vascular endothelial cell growth factor, their uses, and processes for their production The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect of binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within ... 02/02/06 - 20060024784 - Phenol oxidizing enzymes Disclosed herein are novel phenol oxidizing enzymes encoded by nucleic acid capable of hybridizing to the nucleic acid having the sequence as shown in SEQ ID NO:1 and in particular those obtainable from fungus. The present invention provides nucleic acid sequences and amino acid sequences from Bipolaris spicifera, Curvularia pallescens ... 02/02/06 - 20060024783 - Bmp10 propeptides and related methods In certain aspects, the present invention provides BMP10 propeptides for use in treating a variety of disorders including heart disorders and other disorders associated with unwanted activity of the mature BMP10 polypeptide. The present invention also provides methods of screening compounds that modulate activity of BMP10. ... 02/02/06 - 20060024782 - Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell The present invention relates to methods for producing a monoclonal antibody in a heterokaryon fungus or in a fungal host cell. Furthermore, it also relates to a nucleic acid construct a first nucleic acid sequence encoding a light chain of an antibody and a third nucleic acid sequence encoding a ... 02/02/06 - 20060024781 - Detection of truncation mutations by mass spectrometry This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference. ... 02/02/06 - 20060024780 - Wwox: a tumor suppressor gene mutated in multiple cancers The present invention provides the isolation and cloning of WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in several cancers. This gene encodes a tumor suppressor with apoptotic functions. The invention provides WWOX nucleic acid- and polypeptide-based cancer therapies. The invention also provides ... 01/26/06 - 20060019350 - Recombinant negative strand rna virus expression system and vacccines Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The RNA templates are prepared by transcription of appropriate DNA sequences with a DNA-directed RNA ... 01/26/06 - 20060019349 - Position dependent recognition of gnn nucleotide triplets by zinc fingers The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid ... 01/26/06 - 20060019348 - Method of mass producing silk protein and gene recombinant silk-like protein with added functionality A method of producing silk or silk-like protein wherein silk or a silk-like polymer comprising at least one protein selected from among domestic silkworm fibroin, wild silkworm fibroin, elastin and fibronectin, and essentially comprising the aforesaid domesticated silkworm fibroin or silkworm fibroin is designed. The minimum unit of the silk ... 01/26/06 - 20060019347 - Biosynthetic polypeptides utilizing non-naturally encoded amino acids Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided. ... 01/26/06 - 20060019346 - Identification of a novel bitter taste receptor t2r76 that specifically responds to brucine and prop bitter ligands Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably ... 01/26/06 - 20060019345 - Human gabab receptor 1 promoters The present invention relates to nucleic acid molecules constituting GABAB receptor 1 promoters P1a and/or P1b, and to methods for screening for compounds which are modulators of GABAB receptor 1 transcription, said methods comprising the use of nucleic acid molecules constituting GABAB receptor P1a and/or P1b promoters. ... 01/26/06 - 20060019344 - C-erbb-2 external domain: gp75 Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor ... 01/26/06 - 20060019343 - Pichia methanolica secretory signal Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded by a novel Pichia methanolica secretory signal sequence. ... 01/26/06 - 20060019342 - Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis The present invention relates to a reliable, reproducible method for improving the producibility of an antibody. More specifically, this invention provides a method for modifying the heavy chain of an antibody to improve its producibility in eukaryotic cells. Additionally, the method of the invention may improve both antibody producibility and ... 01/26/06 - 20060019341 - Aminopeptidase A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of the yfcK gene and encodes an aminopeptidase. Alternatively, a gram-negative bacterial cell is deficient in a chromosomal gene ... 01/26/06 - 20060019340 - Cd44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6. ... 01/26/06 - 20060019339 - Measurement of bioactive hepcidins The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal; a method for measuring the ... 01/26/06 - 20060019338 - Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods The invention provides an isolated squirrel monkey prokineticin receptor 2 (PKR2) polypeptide containing the amino acid sequence referenced as SEQ ID NO:2; an isolated chimpanzee PKR2 containing the amino acid sequence referenced as SEQ ID NO:4; and an isolated rhesus monkey prokineticin receptor 1 (PKR1) referenced as SEQ ID NO:30. ... 01/26/06 - 20060019337 - Dual expression vector system and screening methods The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect cells. The dual promoter system allows use of the same vector in both host cell systems so that construction of only a single vector is needed to ... 01/26/06 - 20060019336 - Factor vii or viia - like molecules Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided. ... 01/26/06 - 20060019335 - Compositions and methods to promote c-iap autodegradation The present invention generally relates to a method that may be employed as a means to regulate apoptosis. More particularly, the current invention relates to the use of Smac nucleic acid sequences and amino acid sequences expressed therefrom, which promote the ubiquitylation-mediated, auto-degradation of c-IAP. ... 01/19/06 - 20060014252 - Flk-1 binding protein A protein designated flk-1bp binds the vascular endothelial cell surface receptor flk-1. Isolated DNA encoding flk-1bp is provided, along with expression vectors and transformed host cells useful in producing flk-1bp polypeptides. Antibodies that are immunoreactive with flk-1bp are generated using the polypeptides disclosed herein. ... 01/19/06 - 20060014251 - Alternatively spliced isoform of calcium channel, voltage dependent, alpha-ii subunit (cacna1i) The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of calcium channel, voltage dependent, alpha-1I subunit (CACNA1I). The polynucleotide sequence of CACNA1Isv1 is provided by SEQ ID NO 3. The amino acid sequence of CACNA1Isv1 is provided by SEQ ID NO 4. The present invention ... 01/19/06 - 20060014250 - Descendants of bacteria devoid of n terminal formylation useful for the production of proteins and peptides Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain. ... 01/19/06 - 20060014249 - Human g-protein coupled receptor A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or ... 01/19/06 - 20060014248 - Tnf super family members with altered immunogenicity The present invention relates to non-naturally occurring variant Tumor Necrosis Factor Super Family member proteins with reduced immunogenicity. More specifically, the present invention relates to variant BAFF, RANKL, TRAIL, CD40L and APRIL proteins with reduced immunogenicity. ... 01/19/06 - 20060014247 - Method and dna constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separated by a linker region. The DNA construct ... 01/19/06 - 20060014246 - Canine cold- and menthol-sensitive receptor 1 The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays. ... 01/19/06 - 20060014245 - Fusion proteins containing recombinant cytotoxic rnases Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be ... 01/19/06 - 20060014244 - Novel nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, dna fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the ... 01/19/06 - 20060014243 - Human g-protein chemokine receptor hsatu68 Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat ... 01/19/06 - 20060014242 - Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5) In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 ... 01/19/06 - 20060014241 - Extended glucagon-like peptide-1 analogs The invention encompasses GLP-1 peptides with modifications at various positions coupled with an extended C-terminus that provides increased stability. ... 01/12/06 - 20060008880 - Mouse trace amine associated receptors and polypeptides The present invention provides a fingerprint sequence which is specific and selective for trace amine associated receptors (TAAR) forming a subfamily of G protein coupled receptors. The invention also provides the novel mouse polypeptides identified as members of this family, nucleic acids encoding said polypeptides, and vectors and host cells ... 01/12/06 - 20060008879 - Polypeptides having alpha-glucosidase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. ... 01/12/06 - 20060008878 - Monomeric red fluorescent proteins Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. ... 01/12/06 - 20060008877 - Expression systems with sec-system secretion Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides. ... 01/12/06 - 20060008876 - Me-5, me-2, and epp2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with ... 01/12/06 - 20060008875 - Novel tfiih subunit The present invention pertains to a nucleic acid sequence encoding a human TFIIH 8 kDa subunit and related sequences. The nucleic acids may be used in methods for producing a TFIIH subunit, as well as in methods for diagnosing or treating transcription and NER deficiencies, in particular in some forms ... 01/12/06 - 20060008874 - Plant transcriptional regulators of abiotic stress The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, variants of naturally-occurring sequences, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including improved cold and other osmotic stress tolerance, as compared to wild-type ... 01/12/06 - 20060008873 - Cloning and sequencing of allergens of dermatophagoides (house dust mite) Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagolides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II ... 01/12/06 - 20060008872 - Method of improving efficacy of biological response-modifying proteins and the exemplary muteins Disclosed is a protein variant which substitutes valine for phenylalanine residue in a binding domain having a biological response-modifying function by binding to a receptor, ligand or substrate. Also, the present invention discloses a DNA encoding the protein variant, a recombinant expression vector to which the DNA is operably linked, ... 01/05/06 - 20060003421 - Method for purifying a fermentation-derived product Process for purifying a fermentation-derived product. ... 01/05/06 - 20060003420 - Monomeric and dimeric fluorescent protein variants and methods for making same The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomerc structures. The invention also ... 01/05/06 - 20060003419 - Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... 01/05/06 - 20060003418 - Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... 01/05/06 - 20060003417 - Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... 01/05/06 - 20060003416 - Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors Described are means and methods for providing a cell with a protein expression unit, the method comprising providing a nucleic acid sequence comprising the unit with a nucleic acid sequence encoding a binding site for a member of a chromatin modification system for rendering chromatin more accessible for transcription (opener), ... 01/05/06 - 20060003415 - Stable acanthamoeba protein expression systems The present invention relates to stable expression systems for production of a protein comprising: a) a host organism selected from the group consisting of the species of Acanthamoeba; b) a DNA vector which comprises a selection marker gene which codes for a protein which, after transformation of the host organism, ... 01/05/06 - 20060003414 - Signal peptide for producing a polypeptide The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to ... 01/05/06 - 20060003413 - Novel human protein kinase, phosphatase, and protease family members and uses thereof The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin ... 01/05/06 - 20060003412 - Protein engineering with analogous contact environments The invention relates to novel methods for engineering protein sequences using structural and homology information. ... 01/05/06 - 20060003411 - Mutated d-aminotransferase and method for producing optically active glutamic acid derivatives using the same A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183,243 and 244) involved in efficiently producing the (2R, 4R)-monatin in an amino acid sequence of ... 01/05/06 - 20060003410 - Prostaglandin reductase An isolated polypeptide containing the sequence of SEQ ID NO: 1 or a functional equivalent of SEQ ID NO:1, in which the polypeptide reduces 15-keto prostaglandin but not leukotriene B4. Also disclosed is an antibody that binds specifically to the polypeptide and a double-stranded ribonucleic acid for inhibiting expression of ... 01/05/06 - 20060003409 - Novel molecules of the card-related protein family and uses thereof Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into ... 01/05/06 - 20060003408 - Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cells and enzyme compositions including the same which optionally include glucoamylase. ... 01/05/06 - 20060003407 - Methods for preparing highly active april ligand polypeptides The present invention relates to improved methods for producing biologically active truncated APRIL ligand polypeptides and analogs thereof. The invention further relates to truncated APRIL ligand polypeptides and analogs thereof that retain a high biological activity and may be isolated in high yields, as well as the nucleotide sequences that ... 01/05/06 - 20060003406 - Process of purifying vancomycin hydrochloride Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange resin, a weak base anion exchange resin, alumina and a hydrophobic absorbent resin sequentially. ... 01/05/06 - 20060003405 - Method of expressing recombinant protein in cho cells Method of expressing recombinant protein in CHO cells, by using an expression vector comprising the murine IgG 2A gene locus. ... 01/05/06 - 20060003404 - Method for specific integration of t7 rna polymerase gene in the chromosome of corynebacterial and the resultant corynebacteria-t7 promoter based shuttle vector system The present invention relates to method for obtaining optimum expressed proteins in a transformed gram positive bacteria by specific integration of T7 RNA polymerase gene into the chromosome of a gram positive bacteria exhibiting resistance to aminoglycosides, said method comprising:- digesting an E. coli plasmid with a restriction enzyme- digesting ... 12/29/05 - 20050287642 - Efficient protein expression system Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids. ... 12/29/05 - 20050287641 - Gene encoding a nonribosomal peptide synthetase for the production of ramoplanin The present invention relates to isolated genetic sequences encoding nonribosomal peptide synthetase (NRPS) proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms such as Actinoplanes sp. The isolated gene sequences serve as substrates for bioengineering of antibiotic structures. ... 12/29/05 - 20050287640 - Human spasmolytic polypeptide in glycosylated form or a functionally equivalent homologue thereof, characterized by being in glycosylated form. ... 12/29/05 - 20050287639 - Methods of incorporating amino acid analogs into proteins The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs. ... 12/29/05 - 20050287638 - Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same A purified recombinant mammalian HARE comprising a polypeptide which is able to specifically bind at least one of HA, chondroitin and chondroitin sulfate is disclosed, as well as methods of expressing and using same. Also disclosed are functionally active variants of HARE which are able to specifically bind at least ... 12/29/05 - 20050287637 - Engineering intracellular sialylation pathways Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the ... 12/29/05 - 20050287636 - Proapolipoproteina-i mutant and pharmaceutical composition comprising the same for prevention and treatment of atherosclerosis and hyperlipidemia The proapoA-I mutants of the present invention exhibit superior LDL-antioxidant activities over the wild-type proapoA-I and higher efficiencies for delivering cholesterol to hepatocytes than the previously reported apoA-I-R173C, and thus they can be effectively used for prevention and treatment of hyperlipidemia or atherosclerosis. ... 12/29/05 - 20050287635 - Rtd receptor Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided. ... 12/29/05 - 20050287634 - Novel genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or ... 12/29/05 - 20050287633 - Vanilloid receptor The isolated nucleic acid encoding human vanilloid receptor, said receptor, its preparation, cells expressing said receptor and an assay for testing compounds for their potential to decrease pain in humans. The receptor is involved in detection of noxious stimuli in mammalian organisms. ... 12/29/05 - 20050287632 - Peptide amidation process The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2-X3, wherein X2 is any amino ... 12/29/05 - 20050287631 - Compositions and methods related to a dimeric mhc class i and ii-like molecule (dsmhci and dsmhcii) Embodiments of the invention include dimeric soluble MHC molecules (dsMHCs) and compositions and methods for their use. The molecules may be used to downregulate activated T cells. The dsMHCs may be administered by intraperitoneal infusion into a tissue or an organ recipient. The administration of dsMHCs molecules may also be ... 12/29/05 - 20050287630 - Human antibodies derived from immunized xenomice Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se ... 12/29/05 - 20050287629 - Class ii human histone deacetylases, and uses related thereto The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors. ... 12/29/05 - 20050287628 - System and method for the production of recombinant glycosylated proteins in a prokaryotic host A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic information encoding for a metabolic apparatus capable of carrying out the requested N-glycosylation of the target protein. Said prokaryotic organism also contains ... 12/22/05 - 20050282256 - Adipocyte complement related protein zacrp13 The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or ... 12/22/05 - 20050282255 - Monomeric protein of the tgf-beta family The present invention is concerned with proteins selected from the members of the TGF-β superfamily, which are monomeric due to substitution or deletion of a cysteine which is responsible for dimer formation. The invention is also concerned with nucleic acids, encoding such monomeric proteins, vectors or host cells containing the ... 12/22/05 - 20050282254 - Optimized recognition site of the alphavirus non-structural protease for tag removal and specific processing of recombinant proteins The present invention discloses highly efficient novel recognition sites for Pro39 protease. The invention further provides a wide range of conditions for protein purification and modification with the novel recognition sites. The invention even further provides expression vectors for expression of fusion proteins in cells and method to purify fusion ... 12/22/05 - 20050282253 - Therapeutic antiangiogenic endostatin compositions Endostatin compositions capable of inhibiting endothelial cell proliferation, inhibiting angiogenesis and causing tumor regression are described. Specifically, amino acid sequences of endostatin proteins and nucleic acid sequences coding for endostatin proteins are provided. ... 12/22/05 - 20050282252 - Rh(d)-binding proteins and magnetically activated cell sorting method for production thereof The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included. ... 12/22/05 - 20050282251 - Heparanase ii, a novel human heparanase paralog The present invention provides a cDNA encoding a heretofore unknown enzyme termed heparanase II; constructs and recombinant host cells incorporating the cDNA; the heparanase II polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing. ... 12/22/05 - 20050282250 - Method for the recombinant production and purification of protein kinases A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase ... 12/22/05 - 20050282249 - Recombinant hexose oxidase, a method of producing same and use of such enzyme A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and dairy products, animal feed, pharmaceuticals, cosmetics, dental care products and in the manufacturing of lactones. Suitable sources of DNA ... 12/22/05 - 20050282248 - Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the ... 12/22/05 - 20050282247 - Recombinant single chain antibody in heterotrophic algae for pathogen control and use Expression of functionally active recombinant single chain antibody in prokaryotic and eukaryotic heterotrophic algae cells for pathogen treatment or control in aquaculture and agriculture applications is disclosed; and subsequent modification of the strains to generate transgenic algae propagated in defined conditions. ... 12/15/05 - 20050277176 - Human and mouse beta-defensins, antimicrobial peptides The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 β-defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the β-defensin genes encoding the ... 12/15/05 - 20050277175 - Truncated adamts molecules The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods ... 12/15/05 - 20050277174 - Mutant tyrosine repressor, a gene encoding the same, and a method for producing l-dopa A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor. A microorganism which is able to express large amounts of tyrosine phenol-lyase is obtained by introducing the mutant tyrosine repressor into the microorganism. The ... 12/15/05 - 20050277173 - Method for producing human antibodies with properties of agonist, antagonist, or inverse agonist A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of ... 12/15/05 - 20050277172 - Novel variant hypocrea jecorina cbh1cellulases Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility. ... 12/08/05 - 20050272129 - Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity and stress resistance of fungi Methods for enhancing growth in fungi and, more particularly, transgenic fungi expressing the Bcl-2 gene having improved biomass production, survival, longevity and stress resistance in solid and liquid culture are disclosed. Also disclosed are methods of using the transgenic fungi of the present invention for biocontrol. ... 12/08/05 - 20050272128 - Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved therapeutic properties, including antibodies with increased antibody-dependent cellular cytotoxicity. ... 12/08/05 - 20050272127 - Novel polypeptide and gene encoding the same A polypeptide having the amino acid sequence as set forth in SEQ ID NO: 2, 4, or 6, a DNA encoding the same, and an antibody against said polypeptide, and the use thereof. The above amino acid sequence has a homology with chondromodulin-I that has an effect of controlling the ... 12/08/05 - 20050272126 - Testis-specific differentiation-regulatory factor A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also ... 12/08/05 - 20050272125 - Method for making acylated polypeptides The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the ... 12/08/05 - 20050272124 - Polypeptide production in animal cell culture A method of producing a polypeptide in fed batch cell culture is provided which involves an initial cell growth phase and a distinct production phase. In the initial growth stage, animal cells having nucleic acid encoding the polypeptide are cultured at a starting osmolality of about 280-330 mOsm in the ... 12/08/05 - 20050272123 - Novel human g-protein coupled receptor The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as IGS4-family. The invention also relates ... 12/08/05 - 20050272122 - Novel human g-protein coupled receptor The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as IGS4-family. The invention also relates ... 12/08/05 - 20050272121 - Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination Translation systems and other compositions including orthogonal aminoacyl tRNA-synthetases that preferentially charge an orthogonal tRNA with an iodinated or brominated amino acid are provided. Nucleic acids encoding such synthetases are also described, as are methods and kits for producing proteins including heavy atom-containing amino acids, e.g., brominated or iodinated amino ... 12/08/05 - 20050272120 - Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... 12/08/05 - 20050272119 - 2', 5'-oligoadenylate phosphodiesterase Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recombinant plasmid DNAs, processes for screening for 2′,5′-oligoadenylate phosphodiesterase activity inhibitor substances, and processes for screening for 2′,5′-oligoadenylate phosphodiesterase expression regulation ... 12/08/05 - 20050272118 - Novel composition and methods for the treatment of immune related diseases The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease ... 12/08/05 - 20050272117 - Method A method for optimized refolding of a protein which method comprises selecting for the protein at least three control factors which affect refolding of the protein and at least three levels for each control factor, making a Taguchi matrix of the control factors and levels, conducting experiments as required by ... 12/08/05 - 20050272116 - Polymer substrate for recombinant protein purification and environmental remediation A polymer substrate for recombinant protein purification is provided. A process for purifying recombinant proteins is also provided. In general, the present invention is directed to a chelating composition which may be used in a self-supported purification medium for recombinant protein purification. In another embodiment, a process for removal of ... 12/01/05 - 20050266529 - Novel human g-protein coupled receptor The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as IGS4-family. The invention also relates ... 12/01/05 - 20050266528 - Composition exhibiting a von willebrand factor (vwf) protease activity comprising a polypeptide chain with the amino acid sequence aaggilhlellv The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production. ... 12/01/05 - 20050266527 - Human g-protein receptor hibef51 Human G-protein Coupled receptor (HIBEF51) polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to ... 12/01/05 - 20050266526 - Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a ... 12/01/05 - 20050266525 - Expression control sequence An expression control sequence which controls expression of a target gene linked downstream of the expression control sequence depending on an intracellular concentration of an amino acid, wherein in a bacterial cell which harbors a DNA construct comprising the expression control sequence, a promoter linked upstream of the expression control ... 12/01/05 - 20050266524 - Beta integrin gene and protein Recombinant materials for the production of β integrin protein characteristic of Manduca sexta are useful for screening pesticides for this moth. ... 12/01/05 - 20050266523 - Glycorandomization and the production of novel erythronolide and coumarin analogs The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or ... 12/01/05 - 20050266522 - Human amine receptor A Human amine receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting compounds which bind to and activate and bind to and inhibit such polypeptide and the use of compounds for treating diseases ... 12/01/05 - 20050266521 - Production method for iturin a and its homologues (1) A method for producing iturin A and its homologues by cultivating a Bacillus microbe that produces iturin A and its homologue in a medium containing 2 mass % or more of soybean pulverisate or its extract as a nitrogen source to allow the microbe to accumulate iturin A and ... 12/01/05 - 20050266520 - Process for the synthesis of peptides A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching a α-nitrogen protect Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the ... 12/01/05 - 20050266519 - Methods and compositions for modulating and detecting activin dimer and dimer formation Methods and compositions for modulating activin dimer formation, such as the formation of activin dimers formed by the dimerisation of activin subunits βA, βB, βC, βD, or βE, or combinations thereof, are provided. The invention also relates to methods and compositions for detecting an activin monomer or dimer using, for ... 11/24/05 - 20050260714 - Novel compounds Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays. ... 11/24/05 - 20050260713 - Polypeptides and nucleic acids encoding same Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research ... 11/24/05 - 20050260712 - Process for preparing dipeptidyl peptidase iv inhibitors and intermediates therefor with di-tert-butyl dicarbonate to form the BOC-protected amine. ... 11/24/05 - 20050260711 - Modulating ph-sensitive binding using non-natural amino acids The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In ... 11/24/05 - 20050260710 - Methods for producing recombinant polyclonal immunoglobulins (4) culturing said mixture of the transformants, and obtaining mixture of polypeptides from the transformants culture, wherein said polypeptides contain a plurality of types of immunoglobulin variable regions respectively. ... 11/24/05 - 20050260709 - Lipin1 function The present invention addresses the mechanistic role of Lipin1 in the absence of embryonic development. Accordingly, the present invention relates to novel Lipin1 polypeptides and nucleic acids encoding these polypeptides, which polypeptides are involved in body-weight regulation, energy homeostasis, metabolism, obesity, and diabetes. Furthermore, the invention provides substances modulating the ... 11/24/05 - 20050260708 - Proteases and protease inhibitors The invention provides human proteases and protease inhibitors (PPIM) and polynucleotides which identify and encode PPIM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PPIM. ... 11/24/05 - 20050260707 - Corynebacterium glutamicum genes encoding metabolic pathway proteins Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 11/24/05 - 20050260706 - Silk biomaterials and methods of use thereof The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered ... 11/24/05 - 20050260705 - Methods and cells for expression of recombinant protein products under the transcriptional control of an inducible promoter The present invention relates generally to improved methods for the expression of recombinant protein products under the transcriptional control of an inducible promoter, such as an araB promoter, in bacterial host cells that are deficient in one or more of the active transport systems for the inducer of the inducible ... 11/24/05 - 20050260704 - Novel thrombolytic enzyme and a process for its preparation The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant ... 11/24/05 - 20050260703 - Biochemical blocking layer for liquid crystal assay A rubbed substrate structure for use in a liquid crystal assay device, includes: a biochemical blocking compound chemically immobilized on a surface of one side of a support forming a biochemical blocking layer; and a biomolecule recognition agent deposited on the side of the support containing the biochemical blocking layer. ... 11/24/05 - 20050260702 - Novel integrin alpha subunit and uses thereof The invention provides human and murine isolated nucleic acid molecules, designated A259 nucleic acid molecules, which encode secreted proteins with homology to integrin α subunits, specifically to integrin α10. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into ... 11/17/05 - 20050255559 - Isolated nucleic acid molecule(s) encoding a human calcium sensitive potassium channel subunit protein designated beta2, encoded proteins, and uses thereof The present invention is directed to novel human DNA sequences encoding calcium sensitive potassium channel subunits β2, β3a, β3b, β3c, and β3d, the proteins encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of calcium sensitive potassium ... 11/17/05 - 20050255558 - Novel compounds Polypeptides and polynucleotides of the genes set forth in Table 1 and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table 1 in diagnostic assays. ... 11/17/05 - 20050255557 - Novel compounds Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays. ... 11/17/05 - 20050255556 - Refolding of ion channel proteins A method of ion channels folded into their active structure, or functional subunits thereof, is described. For this purpose, initially expressed subunits, which are solubilized and denatured in a first detergent, of an ion channel are provided, and subsequently the first detergent is replaced by a second detergent which induces ... 11/17/05 - 20050255555 - Egf receptor epitope peptides and uses thereof The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically ... 11/17/05 - 20050255554 - Fusion peptides isolatable by phase transition Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a function of solution environment. The invention also provides methods for purifying the FPs, which take advantage of these unique properties, including high-throughput purification methods. ... 11/17/05 - 20050255553 - Mage c2 antigenic peptides and uses thereof This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA ... 11/17/05 - 20050255552 - Antibody specificity transfer using minimal essential binding determinants The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, ... 11/17/05 - 20050255551 - Methods and compositions relating to chimeric nicotinic receptor subunits A chimeric nAChR receptor subunit polypeptide having a substitution of at least about 15% of the native amino acid sequence of the subunit in the area of the C-terminal cytoplasmic domain is provided, as well as polynucleotides encoding the polypeptide. Vectors, host cells, and related methods for evaluating compounds are ... 11/17/05 - 20050255550 - Suppression of xenotransplant rejection This invention relates to the suppression of graft rejection, particularly to the suppression of xenograft rejection. In particular, the invention relates to biological tissues that contain endothelial cells that may be induced to generate a compound which down-regulates the expression of a cell adhesion molecule in these cells. ... 11/17/05 - 20050255549 - Irak-4: compositions and methods of use The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including IL-1 receptors, IL-18 receptors and LPS receptors. IRAK-4 sequences from human ... 11/17/05 - 20050255548 - Protein scaffolds for antibody mimics and other binding proteins Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands. ... 11/17/05 - 20050255547 - Hexamers of receptors, members of the tnf receptor family, their use in therapy and pharmaceutical compositions comprising the same The present invention relates to novel hexamers of receptors, members of the TNF receptor family, their use in therapy and pharmaceutical compositions comprising the same. ... 11/17/05 - 20050255546 - Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation ... 11/17/05 - 20050255545 - Regulation of human hematopoietin receptor-like protein Reagents that regulate human hematopoietin receptor-like protein and reagents which bind to human hematopoietin receptor-like gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, CNS disorders, COPD, cardiovascular disorders, liver disorders, cancer, asthma, and hematological disorders. ... 11/17/05 - 20050255544 - Lipolytic enzyme variants and method for their production The inventors have developed a method using protein engineering to produce lipolytic enzymes having a relatively high activity for one ester bond in an amphiphilic substrate with two lipophilic groups) and a relatively low activity for the ester bond in an amphiphilic substrate with one lipophilic group, e.g. a relatively ... 11/17/05 - 20050255543 - Enzyme-deficient c3 botulinum protein species and their use to promote neuronal growth and neuronal regeneration The present invention is directed to nucleotide sequences and their encoded enzyme-deficient proteins and peptides which regulate neurite especially axonal growth, recognitions agents thereto, and the therapeutic and diagnostic uses of such proteins and peptides. The invention relates also to the use of enzyme-deficient or enzymatic inactive C3 proteins/peptide-derivatives derived ... 11/10/05 - 20050250183 - In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... 11/10/05 - 20050250182 - Novel genes, compositions, and methods for modulating the unfolded protein response The present invention relates to methods and compositions for modulating the unfolded protein response. The method further relates to methods and compositions for the treatment and diagnosis of protein conformational diseases or disorders, including, but not limited to, α1-antitrypsin deficiency, cystic fibrosis, and autoimmune diseases and disorders. The invention further ... 11/10/05 - 20050250181 - Cell-wall degrading enzyme variants The present invention relates to variants of a cell-wall degrading enzyme having a beta-helix structure, which variant has at least one substituent in a position determined by identifying all residues potentially belonging to a stack; characterizing the stack as interior or exterior; characterizing the stack as polar, hydrophobic or aromatic/heteroaromatic ... 11/10/05 - 20050250180 - Secreted protein and polynucleotides encoding them Novel polynucleotides and the proteins encoded thereby are disclosed. ... 11/10/05 - 20050250179 - Inhibition of sulfate-reducing-bacteria-mediated degradation using bacteria which secrete antimicrobials The present invention relates to the field of degradation or corrosion prevention or inhibition through the use of bacteria which secrete antimicrobial chemical compositions. In particular, the invention relates to the use of bacteria which, either naturally or through the use of recombinant technology, secrete chemical compositions which inhibit the ... 11/10/05 - 20050250178 - Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and ... 11/03/05 - 20050244929 - Expression of functional antibody fragments Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab′ and F(ab′)2 antibody fragments are provided. Expression of heavy and light chain Fv in a microbial secretory system is followed by recovery of Fv from the periplasm under conditions that maintain a cysteine residue as a free thiol. ... 11/03/05 - 20050244928 - Method of producing recombinant proteins A method of producing recombinant proteins, or polypeptides, in bacteria or other host cells grown on a substantially solid, i.e., solid or semi-solid, nutrient growth medium harboring DNA sequences of interest for encoding the recombinant proteins under the control of an inducer-regulated promoter or constitutive promoter. The bacteria are harvested ... 11/03/05 - 20050244927 - Process for producing polypeptides A process is described for producing a polypeptide heterologous to E. coli wherein E. coli cells comprising nucleic acid encoding the polypeptide are cultured in a culture medium while feeding to the culture medium a transportable organophosphate, such that the nucleic acid is expressed. The polypeptide is then recovered from ... 11/03/05 - 20050244926 - Novel fructosyl peptide oxidase The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis, and an object of providing a method for producing the fructosyl peptide oxidase. A novel fructosyl peptide oxidase having physicochemical properties ... 11/03/05 - 20050244925 - Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding MP. The ... 11/03/05 - 20050244924 - Methods and constructs for high yield expression of clostripain The invention provides methods and nucleic acid constructs to express clostripain. ... 11/03/05 - 20050244923 - Novel phenol oxidizing enzymes Disclosed herein is the amino acid and nucleic acid sequence for Stachybotrys phenol oxidizing enzymes as well as expression vectors and host cells comprising the nucleic acid. Disclosed herein are methods for producing the phenol oxidizing enzyme as well as methods for constructing expression hosts. ... 11/03/05 - 20050244922 - Bacillus host cell A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 ... 11/03/05 - 20050244921 - Fluorescent protein variants and methods for making same The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomeric structures. The invention also ... 10/27/05 - 20050239168 - Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying ... 10/27/05 - 20050239167 - Fusion polypeptides of human serum albumin and a therapeutically active polypeptide Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides. ... 10/27/05 - 20050239166 - Polynucleotides encoding human secreted protein, zzp1 The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for Zzp1, a novel Zona Pellucida protein. The polypeptides, and polynucleotides encoding them, are fertility modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the Zzp1 polypeptides. ... 10/27/05 - 20050239165 - Method for cultivation of the nitrile-hydratase-producing strain rhodococcus rhodochrous m33 The invention relates to a method for cultivation of the nitrile-hydratase-producing strain Rhodococcus rhodochrous M33, using a culture medium which is based on a 12 to 60 mM phosphate buffer, covers the demand of the cells for phosphorus and maintains the pH in the range of 5.5 to 9.0 during ... 10/27/05 - 20050239164 - Glutathione production The present invention relates to a process for the production of glutathione, wherein said process comprises culturing a mutant yeast strain under conditions promoting glutathione production, and wherein said yeast strain has one or more genetic mutations that result in increased secretion of glutathione into the culture medium relative to ... 10/27/05 - 20050239163 - Mammalian dna binding membrane-associated protein-encoding gene and uses The present invention relates to novel mammalian DNA-R proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian DNA-R proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian DNA-R gene. Also ... 10/20/05 - 20050233416 - Lysine biosynthetic system genes derived from thermophilic bacteria An Escherichia coli mutant strain deficient in dihydrodipicolinate synthase or dihydrodipicolinate reductase is transformed with a chromosomal gene library of Bacillus methanolicus, and a transformant strain which can grow on a minimal medium is selected. Recombinant DNA which codes for dihydrodipicolinate synthase or dihydrodipicolinate reductase is obtained from the transformant. ... 10/20/05 - 20050233415 - Methods for increasing polypeptide production The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at ... 10/20/05 - 20050233414 - Everninomicin biosynthetic genes This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin ... 10/20/05 - 20050233413 - Neuroprotective polypeptides and methods of use Humanin (HN), which has the sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala, is a polypeptide that was identified by screening for molecules that suppress neuronal cell death induced by a gene mutant associated with an familial Alzheimer's disease. The present application provides polypeptides derived from Humanin, which contain one or more D-amino acids or phosphorylated ... 10/13/05 - 20050227329 - Recombinant fibroblast growth factor analogs The DNA sequences encoding analogs of human acidic and basic fibroblast growth factors (FGF) can be recombinantly expressed to obtain practical amounts of proteins useful in effecting both pathologies related to persistent angiogenesis and wound healing and related tissue repair. ... 10/13/05 - 20050227328 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 10/13/05 - 20050227327 - Nicotinamide riboside kinase compositions and methods for using the same The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or ... 10/13/05 - 20050227326 - Method for construction and use of kluyveromyces lactis promoter variants in k. lactis that substantially lack e. coli transcriptional capability Methods and compositions are provided relating to production of recombinant protein in yeast. A modified PLAC4 is described where one or more mutations may be introduced into the Pribnow box-like sequences in the promoter. The modified promoter when placed upstream of a target gene in a vector causes a significant ... 10/13/05 - 20050227325 - Recombinant polynucleotide A highly expressible recombinant polynucleotide is constructed. The recombinant polynucleotide contains a nucleotide sequence encoding a signal peptide derived from the N-terminal region of acid phosphatase present in bacterium belonging to Enterobacteriaceae. In addition the recombinant polynucleotide may contain a nucleotide sequence encoding a protein integrated downstream of the nucleotide ... 10/13/05 - 20050227324 - Monovalent antibody fragments useful as therapeutics The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment. ... 10/13/05 - 20050227323 - Human ipla2epsilon A novel function phospholipase A2, referred to herein as calcium-independent phospholipase A2ε (iPLA2ε) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2ε. This novel enzyme has been isolated and characterized and is ... 10/13/05 - 20050227322 - Recombinant prion-like genes and proteins and materials and methods comprising the same The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; and methods of making and using the foregoing. ... 10/13/05 - 20050227321 - Low-cost production of peptides The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the peptide/AMP as compared to those heretofore known in the art. The subject methods also surprisingly enable the use of Pseudomonas fluorescens to ... 10/13/05 - 20050227320 - Rationally designed polysaccharide lyases derived from chondroitinase b The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from ... 10/13/05 - 20050227319 - Dna sequences coding for enzymes capable of facilitating the synthesis of linear alpha-1,4 glucans in plants, fungi and microorganisms The invention relates to DNA sequences coding for proteins having the enzymatic activity of an amylosucrase which allows the synthesis of linear α-1,4 glucans from the substrate sucrose by bacteria, fungi and plants or in cell-free systems. The invention furthermore describes plasmids and bacteria containing these DNA sequences as well ... 10/13/05 - 20050227318 - Site-specific incorporation of redox active amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active ... 10/13/05 - 20050227317 - Mammalian expression system The present invention relates to protein expression systems and in particular to a mammalian protein expression system. Specifically, the present invention provides a rodent cell line with enhanced protein production capabilities. The invention also relates to eukaryotic cloning and expression vectors and related methods, and in particular to DNA vectors ... 10/13/05 - 20050227316 - Synthetic genes The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important ... 10/13/05 - 20050227315 - Exogenous protein expression system in an avian system The invention concerns the use of an avian cell for producing an exogenous protein of interest in an animal belonging to the avian species, said cell being transformed by an expression vector comprising the gene coding for said protein, said cell being introduced in the sub-germinal cavity of an embryo, ... 10/06/05 - 20050221438 - Novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells and antibodies that identify the same The invention relates to a novel compound termed NKp30 that is selectively expressed by all mature NK cells and that is involved in human natural cytoxicity as an activatory receptor, to new antibodies that bind to the NKp30 structure, and to the pharmaceutical and medicinal uses thereof. ... 10/06/05 - 20050221437 - Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying ... 10/06/05 - 20050221436 - Human neuropeptide y-like g protein-coupled receptor Reagents which regulate human neuropeptide Y-like G protein-coupled receptor (NPY-like GPCR) protein and reagents which bind to human NPY-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, ... 10/06/05 - 20050221435 - Biological material for preparing pharmaceutical compositions intended for treating mammals The invention concerns a biological material for preparing pharmaceutical compositions for treating mammals including either a nucleic acid sequence, containing at least a gene of therapeutic interest and elements expressing the gene in vivo in target cells genetically modified by one such nucleic sequence, or at least a target cell ... 10/06/05 - 20050221434 - Receptor of the edb-fibronectin domains The invention relates to a protein that binds specifically to the EDb-fibronectin domains, process for screening compounds that bind to a receptor of the EDb-fibronectin domains or to EDb-fibronectin domains themselves, as well as the uses of protein. ... 10/06/05 - 20050221433 - Il-18 specific polypeptides and therapeutic uses thereof Fusion polypeptides and multimeric fusion polypeptides capable of binding interleukin-18 (IL-18) with high affinity, as well as nucleic acids encoding the IL-18-specific polypeptides, which are useful therapeutically in methods of treating IL-18-related conditions or diseases. The IL-18-specific polypeptides may include components derived from IL-18 binding protein (IL-18BP), a fusion component ... 10/06/05 - 20050221432 - Methods for altering protein production rates Methods for altering the cellular secretion rate of a protein, such as an antibody and the altered cells produced by the method are disclosed. The methods and altered cells are useful for producing high levels of proteins for therapeutic, diagnostic or research purposes. ... 10/06/05 - 20050221431 - Cysteine-containing peptide tag for site-specific conjugation of proteins The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the ... 10/06/05 - 20050221430 - Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing The invention provides a method of producing multiple polypeptides, such as antibodies or antibody fragments, in a eukaryotic cell using a single expression vector. The expression vector is engineered to comprise two or more expression cassettes under the control of a single promoter wherein the expression cassettes have splice sites ... 10/06/05 - 20050221429 - Host cells containing multiple integrating vectors comprising an amplifiable marker The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector comprising an exogenous gene and an amplifiable marker. The present invention further relates to the use of integrating vectors comprising an amplifiable marker. The ... 10/06/05 - 20050221428 - Chimeric neuropeptide y receptors Novel chimeric G-protein coupled receptors are provided as isolated polypeptides, membrane preparations containing such chimeric receptors, nucleic acids encoding such chimeric receptors, and cells expressing such receptors. The chimeric receptors are NPY5 receptors with most or all of either one or both of the third cytoplasmic loop domain or the ... 10/06/05 - 20050221427 - Method for screening restriction endonucleases Methods for identifying isoschizomers of known restriction endonucleases, which isoschizomers possess a desired physical property, such as thermostability, are also provided by the present invention, as are several novel restriction endonucleases isolated from M. jannaschii, MjaIII and MjaIV. Additionally, a gene was identified that encoded a previously observed endonuclease activity, ... 10/06/05 - 20050221426 - Novel cell-based assays employing voltage and calcium dyes Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated ... 10/06/05 - 20050221425 - Novel temperature regulated promoters and expression vectors for proteins from schizosaccharomyces pombe The present invention relates to novel temperature promoters and set of expression vectors isolated from Schizosaccharomyces pombe. The vectors so developed can be used for regulated expression of proteins, both homologous and heterologous, very efficiently and economically. ... 10/06/05 - 20050221424 - Bispecific molecules for use in therapy and diagnosis of immune related and other diseases Provided are bispecific molecules that are characterized by having at least a first binding domain which binds T-cell immune response cDNA 7 (TIRC7) and a second binding domain which binds HLA-(Human Leukocyte associated Antigen); and optionally comprising further functional domains. Furthermore, compositions comprising said bispecific molecules and their use in ... 10/06/05 - 20050221423 - Bacillus host cell A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more polypeptide(s) involved in sporulation which is at least 80% identical to one or more of the polypeptides shown in SEQ ID ... 10/06/05 - 20050221422 - Novel galactose transferases, peptides thereof and nucleic acid encoding the same The present inventors succeeded in identifying novel galactosyltransferases, C1Gal-T2 and C1Gal-T3, with a 957-bp ORF and 948-bp ORF, respectively. These enzymes were suggested to be core 1 sugar chain (galactose β1-3 acetylgalactosaminyl α1-R) synthetases. These enzymes and the polynucleotides that encode them are expected to serve as suitable therapeutic agents ... 10/06/05 - 20050221421 - Method of producing and using heat shock proteins The present invention relates to a method of manufacturing and using heat shock proteins containing a step of initiating a coagulative necrotic process in a tissue. In particular, a method of manufacturing and using heat shock proteins comprises the steps of heating a tissue to initiate the coagulative necrotic process ... 10/06/05 - 20050221420 - Nogo receptor homologues and their use This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of ... 09/29/05 - 20050214909 - Genes from a gene cluster ML-236B is an inhibitor of HMG-CoA reductase and useful in preparing another such inhibitor, pravastatin. The preparation of ML-236B using an ML-236B-producing microorganism is enhanced using a polynucleotide encoding a gene related to the polyketide synthase cluster occurring in such a microorganism. ... 09/29/05 - 20050214908 - Regulation of human transketolase-like enzyme Reagents which regulate human transketolase-like enzyme and reagents which bind to human transketolase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including but not limited to, cancer, anemia, and end-stage renal disease, including sensory periphery neuropathy associated with uremia. ... 09/29/05 - 20050214907 - Immunoglobulins and method for their modification Heavy chain immunoglobulins that comprise an amino acid with a side chain which is not positively charged, in the first tryptic site, especially at position 27, show increased stability in the gastrointestinal tract. ... 09/29/05 - 20050214906 - Means and methods for regulating gene expression The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with ... 09/29/05 - 20050214905 - Novel compounds Polypeptides and Polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays. ... 09/29/05 - 20050214904 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 09/29/05 - 20050214903 - O-superfamily conotoxin peptides The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. ... 09/29/05 - 20050214902 - Method for albumin purification The present invention is a method of purifying recombinant human serum albumin (rHSA) from a solution, which method comprises to subject a cell culture supernatant (CCS) comprising rHSA cation exchange on a bimodal high salt tolerant matrix; hydrophobic interaction chromatography (HIC); anion exchange; and recovering the purified rHSA. The bimodal ... 09/29/05 - 20050214901 - Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumour cells and/or virally infected cells. A nucleotide sequence encoding ... 09/22/05 - 20050208626 - Sgip peptides The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in ... 09/22/05 - 20050208625 - Monoclonal antibodies with reduced immunogenicity Antibodies having reduced immunogenicity and methods for making them are disclosed. ... 09/22/05 - 20050208624 - Fluorescent protein (3) an amino acid sequence from the 1st amino acid to the (n-1)th amino acid from the N-terminus of the fluorescent protein described in (1) above. ... 09/22/05 - 20050208623 - Expression of granular starch hydrolyzing enzyme in trichoderma The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity. ... 09/22/05 - 20050208622 - 50 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 09/22/05 - 20050208621 - 28 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 09/22/05 - 20050208620 - Compositions and methods for hydroxylating epothilones Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these ... 09/22/05 - 20050208619 - 29 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 09/22/05 - 20050208618 - Novel integrin ligand itgl-tsp ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retinopathy), restenosis, ... 09/22/05 - 20050208617 - N-acetylglucosamintransferase iii expression in lower eukaryotes The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be ... 09/22/05 - 20050208616 - Method and materials for producing deletion derivatives of polypeptides The present invention describes an in vitro transposition-based methodology for generation of deletion derivatives of polypeptides. An artificial transposon containing at least partly within its transposon ends a modification with translation stop codons in three reading frames is provided. In the method, transposition complexes are assembled using the modified transposon ... 09/15/05 - 20050202534 - Binding domain-immunoglobulin fusion proteins The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC ... 09/15/05 - 20050202533 - Maltogenic alpha-amylase variants The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an ... 09/15/05 - 20050202532 - Helical synthetic peptides that stimulate cellular cholesterol efflux The present invention provides peptides comprising at least one amphipathic alpha helix and having an cholesterol mediating activity and a ABCA stabilization activity. The invention further provides methods of using such peptides. ... 09/15/05 - 20050202531 - Cd40 splice variants, compositions for making and methods of using the same Provided are isolated CD40 splice variants that include altered internal sequences and unique tail sequences relative to previously described CD40 protein sequences. Also provided are fragments of the CD40 splice variants comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique ... 09/15/05 - 20050202530 - Enhanced secretion of a polypeptide by a microorganism Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, ... 09/15/05 - 20050202529 - Humanised antibodies CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (78) and (88) and/or (91). The CDR-grafted light chains comprise ... 09/15/05 - 20050202528 - Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of ... 09/15/05 - 20050202527 - Thrombin-cleavable chimeric proteins The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide ... 09/15/05 - 20050202526 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 09/08/05 - 20050196841 - Modified chitin-binding domain and use thereof Compositions and methods are provided for reversibly binding chitin binding domain (CBD) to a chitin or equivalent substrate under non denaturing conditions. CBD is modified preferably by a mutation to achieve this change in properties. In one embodiment, an aromatic amino acid residue located in the binding cleft of the ... 09/08/05 - 20050196840 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 09/08/05 - 20050196839 - Beta-secretase enzyme compositions and methods Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some ... 09/08/05 - 20050196838 - Anti-il-12 antibodies and nucleic acids The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices. ... 09/08/05 - 20050196837 - Artificial mammalian chromosome The invention relates to the field of gene therapy, gene expression, and vectors for these uses. In particular, the invention relates to the development and use of an artificial or synthetic chromosome for gene expression and gene therapy in mammals, and especially humans. The invention allows the controlled construction of ... 09/08/05 - 20050196836 - Gamma-glutamylcysteine producing yeast A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an aspartic acid ... 09/08/05 - 20050196835 - Cold-active beta galactosidase, the process for its preparation and the use thereof The present invention relates, for example, to an isolated DNA comprising a sequence which encodes a cold-active beta galatosidase that is specific for lactose and has a stable enzymatic activity at a temperature below 8° C. In embodiments of the invention, the DNA is isolated from the psychrophilic bacterium Pseudoalteromonas ... 09/08/05 - 20050196834 - Stable gene variants of lipases The present invention relates to the generation and production of novel thermostable, organic solvent stable and pH tolerant lipase gene variants. The invention also relates to methods of selecting lipase variants for high temperatures and for their purification. ... 09/08/05 - 20050196833 - Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding. cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides. ... 09/08/05 - 20050196832 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 09/08/05 - 20050196831 - Human g-protein chemokine receptor (ccr5) hdgnr10 Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat ... 09/08/05 - 20050196830 - Amino acid modified polypeptides Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are introduced into recombinant host cells and expressed. Trimeric collagen is recovered from the recombinant host cells. ... 09/08/05 - 20050196829 - Haplotypes of the fcer1a gene Novel genetic variants of the Fc Fragment Of Ige, High Affinity I, Receptor For; Alpha Polypeptide (FCER1A) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the FCER1A gene. Compositions and methods for haplotyping and/or genotyping the FCER1A gene ... 09/01/05 - 20050191727 - Cytomegalovirus intron a fragments Cytomegalovirus (CMV) Intron A fragments for expressing gene products are disclosed. Also described are expression vectors including the fragments, as well as methods of using the same. ... 09/01/05 - 20050191726 - Expression of heterologous multi-domain proteins in yeast This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the inclusion of a plurality of (up to three) modular expression cassettes which may encode multiple polypeptide chains of a heterologous multi-domain protein on ... 09/01/05 - 20050191725 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 09/01/05 - 20050191724 - Nematode-extracted serine protease inhibitors and anticoagulant proteins Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized ... 09/01/05 - 20050191723 - Method for simultaneous production of multiple proteins; vectors and cells for use therein The invention relates to the field of biochemistry, molecular biology, pharmacology and diagnosis. More specifically the present invention relates to the production of proteins in a host cell. Even more specifically, the invention relates to a method for improving expression of two or more proteins in a (host) cell. The ... 09/01/05 - 20050191722 - Streptavidin-binding peptides and uses thereof The invention provides peptides with high affinity for streptavidin. These peptides may be expressed as part of fusion proteins to facilitate the detection, quantitation, and purification of proteins of interest. ... 09/01/05 - 20050191721 - Tim-3 ligands and methods thereof The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a ... 09/01/05 - 20050191720 - Surface expression method of peptides p5 and anal3 using the gene encoding poly-gamma-glutamate synthetase The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from ... 08/25/05 - 20050186661 - Production of protease from bacillus stearothermophilus f1 A biologically pure strain of Bacillus stearothermophilus F1 capable of Producing protease which is tolerant to any organic compound selected from the group leucine, cysteine, arginine, glycine, asparagine (BDH) and aspartic acid. Peptone iv derived from soybean was the best organic compound for the enzyme production. Sodium nitrate, ammonium salts ... 08/25/05 - 20050186660 - Human procalcitonin and the preparation and use thereof The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing ... 08/25/05 - 20050186659 - Methods for protein purification The present invention relates to process for the production of a soluble polypeptide having at least one ligand binding site, the process comprising (i) providing a host cell comprising a nucleic acid sequence encoding the soluble polypeptide; (ii) culturing the host cell under conditions whereby the polypeptide is produced, wherein ... 08/25/05 - 20050186658 - Chimeric metabotropic glutamate receptors and uses thereof The present invention provides chimeric receptors that include an extracellular domain from a metabotropic glutamate receptor and a non-native signal peptide, e.g., a calcium receptor signal peptide. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate ... 08/18/05 - 20050181481 - Hadhs as modifiers of the p21 pathway and methods of use Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided. ... 08/18/05 - 20050181480 - Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence ... 08/18/05 - 20050181479 - Periplasmic expression of antibodies using a single signal sequence The present invention relates to recombinant polynucleotides, expression vectors and methods for the production of multimeric proteins. The vectors and methods are useful for the production of multimeric protein and are unique in that they utilize a minimal number of signal sequences. More specifically, the present invention provides recombinant polynucleotide ... 08/18/05 - 20050181478 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 08/18/05 - 20050181477 - Extracellular/epidermal growth factor like protein The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and ... 08/18/05 - 20050181476 - Novel splice variant of myd88 and uses thereof The present invention relates to the field of infection and inflammation and, more specifically, to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88S), which has been identified encoding a protein that inhibits LPS-induced NF-κB activation. MyD88S is a target to ... 08/18/05 - 20050181475 - Immunogenic monoclonal antibody The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen. ... 08/18/05 - 20050181474 - Transport peptides and uses therefor The invention describes isolated transport peptides, which cross the cell membrane of a cell and/or home to a target cell. The invention also describes a transport complex in which a transport peptide is linked to a cargo moiety to be delivered into/to a cell. Methods are disclosed describing delivery of ... 08/18/05 - 20050181473 - Bacterial adpglucose pyrophospatase method for obtaining the latter and its use in the production of assay devices and in the obtention of transgenic plants and bacteria Bacterial ADPglucose pyrophosphatase, method of production, use in the manufacture of testing devices and in the production of transgenic plants and bacteria. AGPPase is an enzyme that catalyzes the hydrolysis of ADPG (adenosine diphosphate glucose). The enzyme obtained from microbial extracts is used in testing devices for determining levels of ... 08/18/05 - 20050181472 - Butinol i esterase The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis ... 08/11/05 - 20050176103 - Vascular endothelial growth factor 2 Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound ... 08/11/05 - 20050176102 - Totipotent hematopoietic stem cell receptors and their ligands Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. ... 08/11/05 - 20050176101 - Enzyme expression methods Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme and/or for identification of soluble and/or active catalytic domains by systematic variation of fragment lengths around catalytic domain boundaries. ... 08/11/05 - 20050176100 - Zace1: a human metalloenzyme Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin H from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc ... 08/11/05 - 20050176099 - Plasmid system for multigene expression The present invention provides a plasmid system which facilitates the construction of a single amplifiable plasmid that, having the potential to accommodate many independent expression cassettes, has the ability to express multi-subunit complex proteins such as antibodies and receptors. ... 08/11/05 - 20050176098 - Human ion channels The present invention provides novel ion channel polypeptides and polynucleotides that identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The invention also provides methods for the identification of ion channel agonists/antagonists, useful for the treatment of human diseases and conditions. ... 08/11/05 - 20050176097 - Bacillus host cell A Bacillus licheniformis mutant host cell comprising a mutation (deletion) in one or more genes encoding polypeptides having proteolytic activity wherein the mutant host cell expresses at least 5% less of the one or more proteases than the parent host cell, when cultivated under comparable conditions. The mutant host cell ... 08/11/05 - 20050176096 - Stabilized biocatalysts and methods of bioconversion using the same The present invention relates to a biocatalyst displayed on spore or virus surface and a method of bioconversion using the same, in particular to a method of bioconversion using a biocatalyst, which comprises the steps of: (a) preparing a vector for spore surface display comprising a gene construct containing a ... 08/11/05 - 20050176095 - Transcriptional factor, transcriptional factor gene, recombinant vector containing transcriptional factor gene, koji-mold transformed by the vector and method of using koji-mold This invention provides a transcription factor that has functions of regulating the expression of a sulfur-assimilatory gene of koji mold during culture, and a gene encoding the same. This invention also relates to a protein comprising the amino acid sequence as shown in SEQ ID NO: 3, and a gene ... 08/11/05 - 20050176094 - Interferon-alpha induced gene The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ. ID. No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-α and other interferons which act at ... 08/04/05 - 20050170466 - Equine fc epsilon receptor alpha protein The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present ... 08/04/05 - 20050170465 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 08/04/05 - 20050170464 - Prokaryotically produced antibodies and use thereof The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment. ... 08/04/05 - 20050170463 - Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus e1a and e1b proteins The invention provides a method for producing at least one polypeptide of interest in a eukaryotic cell, the method comprising: providing a eukaryotic cell comprising nucleic acid encoding the polypeptide of interest; culturing the cell in a suitable medium; and harvesting the at least one polypeptide of interest from the ... 08/04/05 - 20050170462 - Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics. ... 08/04/05 - 20050170461 - Polypeptides, their production and use The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and ... 08/04/05 - 20050170460 - Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl trna synthetases The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl ... 08/04/05 - 20050170459 - Thymic stromal lymphopoietin receptor molecules and uses thereof The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, ... 08/04/05 - 20050170458 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 08/04/05 - 20050170457 - Novel recombinant proteins with n-terminal free thiol where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino ... 08/04/05 - 20050170456 - Enhanced secretion of a polypeptide by a microorganism Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, ... 08/04/05 - 20050170455 - Novel prokineticin receptor isoforms and methods of use The invention provides an isolated prokineticin receptor 2 long isoform polypeptide that contains an amino acid sequence selected from the amino acid sequences referenced as SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4. Also provided is an isolated prokineticin receptor 2 short isoform polypeptide, which contains the amino ... 08/04/05 - 20050170454 - Cell culture medium A method for culturing cells in the presence of an alcanoic acid for enhancing protein production. ... 08/04/05 - 20050170453 - Modified promoter It is intended to provide base sequences participating in the regulation of the expression of a promoter. It is also intended to modify a promoter based on the base sequence data to give a modified promoter having a high expression activity. Namely, a modified promoter constructed by inserting a first ... 08/04/05 - 20050170452 - Method to engineer mammanlian-type carbohydrate structures The present invention relates to host cells having modified lipid-linked oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be ... 08/04/05 - 20050170451 - Human type antihuman ige receptor antibody and fragment An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor ... 08/04/05 - 20050170450 - Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells Disclosed is a new process for the production of recombinant proteins, by transient transfection of suspension-grown human embryonic kidney cells (293 cell line and its genetic variants) with an expression vector, using polyethylenimine (PEI) as a transfection reagent. In a preferred embodiment, the process uses 293E cells expressing the Epstein-Barr ... 07/28/05 - 20050164350 - Heat-resistant thioredoxin and related enzymes The inventors isolated from hyperthermophilic archaebacteria Aeropyrum pernix a heat resistant thioredoxin, thioredoxin reductase and thioredoxin peroxidase having at least 50% residual activity after heat treatment at 100° C. for 0.5 hour, and sequenced the amino acid and base sequences. The inventors also isolated from hyperthermophilic archaebacteria Pyrococcus horikoshii a ... 07/28/05 - 20050164349 - Methods for enhancing expression of recombinant proteins The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system. ... 07/28/05 - 20050164348 - Method of suppressing differentiation by administering a human serrate-1 polypeptide A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to ... 07/28/05 - 20050164347 - Actinobacillus succinogenes shuttle vector and methods of use An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, ... 07/28/05 - 20050164346 - Actinobacillus succinogenes shuttle vector and methods of use An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, ... 07/28/05 - 20050164345 - Synthesis of human procollagens and collagens in recombinant dna systems Methods of making collagen with hosts, and vectors that express collagen, and collagen post-translation enzymes are disclosed. Collagen post-translation enzymes include prolyl-4-hydroxylase, lysyl hydroxylase, lysyl oxidase, C-proteinase, and N-proteinase, and these enzymes increase the yield of properly folded, recombinant collagen in non-mammalian hosts. The collagens produced by these methods, hosts, ... 07/28/05 - 20050164344 - Nucleic acid molecule encoding homer 1b protein A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a ... 07/28/05 - 20050164343 - Novel compounds Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays. ... 07/28/05 - 20050164342 - Cloned glutamic acid decarboxylase cDNA molecules coding for GAD65 polypeptide. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD65. The invention further ... 07/28/05 - 20050164341 - Methods of purification of cytochrome p450 proteins and of their crystallizing The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from said culture and suspending said cells in a high salt buffer; lysing said cells and removing cell debris to provide a ... 07/21/05 - 20050158830 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to herologous polypeptide sequences, antibodies which bind to the polypeptides ... 07/21/05 - 20050158829 - Fusion polypeptides capable of activating receptors A fusion polypeptide comprising (A)x—M—(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a ... 07/21/05 - 20050158828 - Production of tetravalent antibodies The present invention relates to a novel process for the preparation of biologically active antibody dimers in a pharmaceutically acceptable composition. The dimers can be composed of two antibody molecules having the same antigen binding specificity and linked through a reducible, disulfide, or a non-reducible thioether, bond (homodimer). Alternatively, the ... 07/21/05 - 20050158827 - Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors ... 07/21/05 - 20050158826 - Treating arthritis by cleaving tnf receptors The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifying additional compounds that influence TNF receptor shedding. As the active ... 07/21/05 - 20050158825 - Production of functional antibodies in filamentous fungi Described herein are methods for the production of monoclonal antibodies in filamentous fungi host cells. The monoclonal antibodies are expressed as full-length fusion proteins that retain functional antigen binding and antibody-dependent cellular cytotoxicity capabilities. Improvements in the cleavage of the glucoamylase-light chain fusion protein to yield a mature antibody are ... 07/21/05 - 20050158824 - Neublastin expression constructs A method of producing a secreted neublastin polypeptide using a heterologous signal sequence is disclosed. The secreted neublastin does not contain a neublastin pro sequence. ... 07/21/05 - 20050158823 - Method of using a cytokine that induces apoptosis A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well. ... 07/21/05 - 20050158822 - High level expression of recombinant human erythropoietin having a modified 5'-utr The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5′-UTR sequence and a truncated 3′-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and ... 07/21/05 - 20050158821 - Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into ... 07/14/05 - 20050153398 - Flavobacterium heparinum expression system This invention is directed to Flavobacterium heparinum for use as a host cell organism for the expression of homologous and heterologous genes. ... 07/14/05 - 20050153397 - Methods for producing polypeptides in aspergillus mutant cells The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the ... 07/14/05 - 20050153396 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention used to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 07/14/05 - 20050153395 - Unique integrin binding site in connective tissue growth factor (ctgf) The invention relates to a connective tissue growth factor peptide that encompasses a CTGF binding site for an integrin such as αvβ3 or α5β1 and uses therefor. The invention also relates to agonists and inhibitors of the CTGF-integrin binding and methods of treating and preventing CTGF-related disorders. ... 07/14/05 - 20050153394 - Expression vector This invention provides nucleic acids and expression vectors, and host cells transformed with the same, for providing high expression of a desired polypeptide. Also provided are methods of using the expression vectors, nucleic acids, and host cells which have been modified by these compositions, for increasing expression of a gene ... 07/14/05 - 20050153393 - Enhanced secretion of a polypeptide by a microorganism Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, ... 07/14/05 - 20050153392 - Transgenesis with humanized immunoglobulin loci The invention concerns recombinase-mediated transfer of human or humanized immunoglobulin loci into the genome of non-human transgenic animals. In particular, the invention relates to improved methods to integrate human and/or humanized immunoglobulin loci into the genome of non-human animals using transgenic constructs which contain immunoglobulin loci comprising human gene sequences ... 07/14/05 - 20050153391 - Ligand to gpr8 and dna thereof The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc. The ligand to GPR8 of the present invention is useful in developing a ... 07/07/05 - 20050148051 - Cloning and characterization of a human adenylyl cyclase A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described. ... 06/30/05 - 20050142640 - Muc-1 derived peptides Described are peptides and polypeptides derived from the MUC-1 polypeptide which are able to activate Cytotoxic T Lymphocyte (CTL) response, analogues of such peptides and polypeptides nucleotide sequences encoding such peptides and polypeptides and therapeutic uses thereof. Moreover, indications for selecting appropriate minimal antigenic MUC-1 polypeptides with reference to the ... 06/30/05 - 20050142639 - Method of producing apolipoprotein analogues The invention relates to a pharmaceutical composition comprising an apolipoprotein construct, to an apolipoprotein construct, a nucleic acid sequence encoding the apolipoprotein construct, a vector comprising the nucleic acid sequence, a method for producing the apolipoprotein construct, and a method of treatment comprising administering the apolipoprotein construct. The presented data ... 06/30/05 - 20050142638 - Proteases from gram-positive organisms The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of ... 06/30/05 - 20050142637 - Long-wavelength fps Two long-wavelength fluorescent proteins isolated from the strawberry anemone, Corynactis californica are provided. These proteins are homologous to known fluorescent proteins, but their unique properties, including yellow or red color of emission, can find use in replacing and supplementing known fluorescent proteins. In addition, because of their longer wavelength absorption ... 06/30/05 - 20050142636 - Process of high purity albumin production A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an ... 06/30/05 - 20050142635 - Reshaped human antibody to human interleukin-6 receptor A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 ... 06/30/05 - 20050142634 - Novel modulator of non-genomic activity of nuclear receptors (mnar) and uses thereof A novel protein modulator of non-genomic activity of nuclear receptors (MNAR), which interacts with estrogen receptors alpha (ERα), estrogen receptor beta (ERβ), and other nuclear receptors, was discovered and characterized. An MNAR-ER complex, in vitro and in vivo, relates to nucleic acids, antisense, recombinant expression of nucleic acids, as well ... 06/23/05 - 20050136515 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 06/23/05 - 20050136514 - Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying ... 06/23/05 - 20050136513 - Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation. ... 06/23/05 - 20050136512 - Galphaq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors The invention provides a series of Gαq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. ... 06/23/05 - 20050136511 - Gaba b receptors The invention relates to polypeptides which exert the biological activity of GABA B receptors, and to nucleic acids which encode these polypeptides, and in particular to their use for finding active compounds for crop protection. ... 06/16/05 - 20050130268 - Method of suppressing differentiation by administering a human serrate-1 polypeptide A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to ... 06/16/05 - 20050130267 - Modulation of gene expression using localization domains Methods and compositions for regulating gene expression are provided. In particular, methods and compositions comprising localization domains, and fusions of localization domains with DNA binding domains and, optionally regulatory domains, are provided. ... 06/16/05 - 20050130266 - Prosuction of antibodies or (functionalized) fragments thereof derived from heavy chain immounogobulins of camelidae A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an example DNA sequence encoding the antibody or (functionalized) fragment thereof, wherein the antibody or (functionalized) fragment thereof is derived from a heavy chain immunoglobulin of ... 06/16/05 - 20050130265 - Aiolos, helios, daedalos and ikaros: genes, polypeptides, regulatory elements and uses thereof Provided herein are (a) Aiolos gene, Aiolos polypeptides, Aiolos homodimers, Aiolos/Ikaros heterodimers and methods of using Aiolos nucleic acids and polypeptides; (b) Helios gene, Helios polypeptides, Helios homodimers, Helios/Ikaros heterodimers, Helios/Aiolos heterodimers, and methods of using Helios nucleic acids and polypeptides; (c) Daedalos nucleic acids, Daedalos polypeptides, and other related ... 06/16/05 - 20050130264 - Nucleotide sequences which code for the rpob gene The present invention relates to polynucleotides corresponding to the rpoB gene and which encode the β-subunit of RNA polymerase B, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having activity of the β-subunit of RNA polymerase B. ... 06/16/05 - 20050130263 - Compositions isolated from bovine mammary gland and methods for their use Isolated polynucleotides encoding polypeptides expressed in bovine mammary gland tissue are provided, together with genetic constructs and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided. ... 06/16/05 - 20050130262 - Mutated photoproteins and their uses Mutated photoproteins derived from isolated jellyfish photoproteins, characterised in that they exhibit a thermostability higher than that of the photoproteins from which they are derived, and are called thermostable mutated photoproteins, and/or a luminescence duration longer than that of the photoproteins from which they are derived, and are called persistent ... 06/09/05 - 20050124042 - Method for expression of heterologous proteins in yeast Compositions and methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form using a yeast host cell as the expression system are provided. Compositions of the invention are nucleotide sequences encoding a signal peptide sequence for a yeast secreted protein, an optional leader peptide ... 06/09/05 - 20050124041 - Antibody variable region of a monoclonal antibody against human tumor necrosis factor alpha and a gene encoding the same An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic ... 06/09/05 - 20050124040 - Novel dehydrogenase and a gene encoding the same The object of the present invention is to provide a novel dehydrogenase having a property which is different from that of known dehydrogenases. The present invention provides a dehydrogenase having the following physicochemical properties: (1) effect: to produce N-alkyl-L-alanine from pyruvic acid and alkylamine or dialkylamine using NADPH and/or NADH ... 06/09/05 - 20050124039 - Genetic immunization with cationic lipids A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also disclosed. A method for epitope mapping is also disclosed. ... 06/09/05 - 20050124038 - Transfection of cartilage and matrices thereof in vitro The invention provides methods for transfecting and/or transducing neocartilage or juvenile cartilage comprising infecting cultured neocartilage or juvenile cartilage with a recombinant vector. Preferably, the vector is adenovirus fiber type 51. Transfected and/or transduced chondrocyte cells and intact neocartilage or juvenile cartilage are also provided. ... 06/09/05 - 20050124037 - Nucleic acid molecules encoding proteins which impart the adhesion of neisseria cells to human cells Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid molecules and antibodies directed against them. Furthermore, pharmaceutical compositions, vaccines and diagnostic compositions containing the nucleic acid molecules, proteins and/or antibodies ... 06/09/05 - 20050124036 - Method for producing recombinant proteins in micro-organisms The invention relates to a method for producing a recombinant functional plasminogen in micro-organisms, and to a method for identifying plasminogen activators. The nucleic acid sequence coding for the fuctional part of the plasminogen is fused with a nucleic acid molecule coding for at least one signal peptide. The nucleic ... 06/02/05 - 20050118681 - Novel regulatory molecule and genetic sequences encoding same The present invention relates generally to a regulatory molecule and to genetic sequences encoding same. More particularly, the present invention provides a molecule involved in, associated with or which otherwise facilitates myogenesis. In a particularly preferred embodiment, the regulatory molecule is a transcription factor involved in the expression of genes ... 06/02/05 - 20050118680 - Human chemotactic protein A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating ... 06/02/05 - 20050118679 - Novel metalloproteinases The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for ... 06/02/05 - 20050118678 - Modified polypeptides with therapeutic activity and methods of use Polypeptides modified by fatty acid conjugation and methods of using such modified polypeptides in treating bacterial infections, including the treatment of antibiotic resistant bacterial infections, are disclosed. ... 06/02/05 - 20050118677 - Cc chemokine receptor 5 dna, new animal models and therapeutic agents for hiv infection The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCRS plays an essential role in the membrane fusion step ... 06/02/05 - 20050118676 - Gene therapy vectors having reduced immunogenicity The present invention provides compositions and methods for specifically inhibiting host immune responses against expression vectors and target cells transfected with such vectors. In particular, methods of specifically inhibiting the humoral and cellular components of the host immune response to vector-associated antigens and target-cell associated antigens are described. ... 06/02/05 - 20050118675 - Heptahelix receptor and its use as leukotriene b4 receptor A full-length cDNA encoding a 352-amino-acid protein contains seven regions of hydrophobic amino acids representing membrane-spanning domains of a heptahelix receptor, tentatively named CMKRL1. It shows nearly 30% overall identity with the c5a anaphylatoxin receptors and similar degree of homology with other chemoattractant receptors. Receptor expression was shown in lymphoid ... 06/02/05 - 20050118674 - Engineering of controlled deamidation rates in peptides, proteins, and similar structures Experiments that quantitatively determine the sequence dependence of deamidation and three-dimensional structure observations have been carried out. These experiments and theoretical computation methods based upon them, allow the invention of techniques for engineering of deamidation rates for amides in peptides, hormones and proteins as well as peptide-like, hormone-like and protein-like ... ### FreshPatents.com Support - Terms & Conditions |