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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Viable Micro-organism > Testing For Antimicrobial Activity Of A Material Testing For Antimicrobial Activity Of A MaterialTesting For Antimicrobial Activity Of A Material patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/12/07 - 20070082376 - Device and method for determining antibiotic susceptibility The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present ... 04/12/07 - 20070082375 - Method for treating onychomycosis A novel method for evaluating an effect of an antimicrobial agent which comprises removing the antimicrobial agent remaining in a biological sample or the like to thereby accurately evaluate the effect of the antimicrobial agent without being affected by the remaining antimicrobial agent. A therapeutic agent for onychomycosis which can ... 03/15/07 - 20070059788 - Method and apparatus for electrically detecting an adverse effect of a toxic substance on procaryotic cells A method and apparatus for electrically measuring an adverse effect of toxic substances on prokaryotic cells includes measuring a whole intracellular change caused by the presence of toxic substances as a change in an electric signal of cell membranes of the prokaryotic cells. According to the present invention, it is ... 03/08/07 - 20070054349 - Biochip A biochip comprising a substrate defining a plurality of fluid holding areas, the fluid holding areas separated by fluid separating elements for preventing mixing of fluids held in the fluid holding areas until the application of pressure to one or more of the fluids. ... 02/22/07 - 20070042453 - High throughput screening method for antimicrobial formulations Methods and systems are provided for increasing the speed and throughput at which the antimicrobial effects of chemical formulations can be evaluated. Generally, the invention provides a method for screening antimicrobial chemical formulations, comprising depositing microorganisms on a slide, depositing chemical formulations onto the deposited microorganisms, removing the chemical formulations ... 02/08/07 - 20070031915 - Blood and urine test The present invention provides a test medium comprising a test microorganism, an indicator and a metal in ionized form, wherein the valence of said metal is at least 2 and the concentration of said metal is between 0.001 M and 1 M. Furthermore, there is provided a method for the ... 12/21/06 - 20060286624 - Method for identifying selective growth inhibitors Selective growth inhibitors are identified by (i) providing a semi-solid nutrient medium (e.g., an agar plate) co-seeded with a strain of cells (e.g., bacteria or fungi) that is sensitive to growth inhibitors having a particular mode of action and with a strain that is essentially the same as the sensitive ... 12/14/06 - 20060281141 - Method for isolating potential antibiotic microorganisms The present invention provides a method identifying nonparaffinophilic microorganisms suitable for antibiotic screening. The method provides the growing of nonparaffinophilic microorganisms on substrates in a bioreactor, wherein the bioreactor provides an environment conducive to the metabolism of many nonparaffinophilic microorganisms while being restrictive to methanogens and methane production. The method ... 11/09/06 - 20060252114 - Compound combinations for inhibiting cell division and methods for their identification and use The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell ... 11/09/06 - 20060252113 - Methods for identifying compounds that modulate an enzyme in the glucose metabolic pathway of a pathogenic microorganism A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and ... 11/09/06 - 20060252112 - Methods for indentifying compounds that modulate an enzyme involved in biotin metabolism in a pathogenic microorganism A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and ... 10/26/06 - 20060240505 - Identification of targets of antimicrobial compounds A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method ... 10/05/06 - 20060223136 - Scytalone dehydrogenase gene showing tolerance to agricultural pesticide The present invention provides a gene that can be used extensively in studies relating to resistant rice blast fungi. The gene codes for either one of the following proteins (a) or (b): (a) a protein consisting of the amino acid sequence shown in SEQ ID NO:2; or (b) a protein ... 09/21/06 - 20060211082 - Methods and compositions for rapidly detecting and quantifying viable legionella Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed. ... 09/21/06 - 20060211081 - Sec14 as an antifungal target The invention provides SEC14 cytosolic factor (SEC14) as a novel antifungal target, screening methods for SEC14 inhibitors and their use as antifungal compounds, pharmaceutical compositions containing them and their use in medicine. ... 09/07/06 - 20060199242 - Chemical probe compounds that become fluorescent upon reduction, and methods for their use Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including ... 08/03/06 - 20060172368 - Cgt1 as an antifungal target The invention provides CGT1 guanylyltransferase (CGT1) as a novel antifungal target, screening methods for CGT1 inhibitors and their use as antifungal compounds, pharmaceutical compositions containing them and their use in medicine. ... 06/22/06 - 20060134726 - Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents Particular aspects provide a method of sampling, testing and validating test lots (e.g., single-unit production lots), comprising: assembling a plurality of product portions from each of a plurality of test lots and combining the collected product portions to provide a corresponding set of test lot samples (wherein each test lot ... 06/22/06 - 20060134725 - Method for the determination of the presence of an antibiotic in a fluid The present invention provides a method for determining the presence or absence of an antibiotic in a fluid comprising: (a) contacting a fluid sample with a test medium comprising a test microorganism and at least one indicator; (b) incubating the test microorganism with the fluid under conditions whereby growth of ... 06/22/06 - 20060134724 - Method and probe for identifying bacterial virulence modifying agents, agents thus identifed, and their use A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+ depleted bacteria with an agent the antibacterial effect of which shall be determined, recording the light emitted by the bacteria upon addition of an aldehyde, the incubation being carried ... 06/15/06 - 20060127968 - Protozoan rhomboid proteins Protozoan Rhomboid Proteins This invention relates to the identification of protozoan Rhomboid proteins that are involved in the invasive processes of protozoan pathogens, such as P. falciparum. Modulation of these Rhomboid proteins may thus be useful in treating protozoan pathogen infection. Methods and means relating to the modulation of protozoan ... 06/15/06 - 20060127967 - In vitro test for studying compound predicting pharmacologic and/or harmacokinetic and/or pharmacodynamic parameters of a compound The invention provides a method and an assay for predicting the pharmacologic and/or pharmacokinetic and/or pharmacodynamic activity and/or effective concentration of a test material using cell and/or protozoa and/or micro-organism by assessing the effect of the test material on the and/or protozoa and/or micro-organism. Further, the invention provides an apparatus ... 05/04/06 - 20060094075 - Methods for indentifying compounds that modulate an enzyme in the coenzyme a biosynthetic pathway in a pathogenic microoganism A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and ... 04/27/06 - 20060088902 - Methods and materials for the identification of antifungal substrates in filamentous fungi The present invention relates to a method for the identification of antifungal substrates, in particular substrates which are capable of combating filamentous fungi by disturbing cell wall biogenesis. A nucleotide sequence encoding α-1,3-glucan synthase including its promoter sequences is provided, obtainable from Aspergillus niger, which can be used to develop ... 03/23/06 - 20060063224 - Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway ... 02/16/06 - 20060035310 - Media for recovery of microorganism in the presence of antibiotics The present invention provides a media and a method of using such as media for the bioburden or sterility testing of antibiotics or environmental testing of antibiotic manufacturing areas. The medium contains one or more divalent or trivalent cation constituents, preferably of magnesium, calcium, aluminum and iron that allow for ... 02/16/06 - 20060035309 - Method of detecting meticillin-resistant micro-organisms The invention relates to a novel solid medium for detecting meticillin-resistant micro-organisms, containing an antibiotic selected from the cephalosporin group, particularly second and third generation, and a chromogenic agent bearing a chromophore which is released after hydrolysis with an active enzyme in said micro-organisms. ... 12/22/05 - 20050282242 - Screening assays for antimicrobial agents The present invention provides methods for screening antimicrobial agents that make use of mutated microbial polypeptides. Because these polypeptides have biological activity and result in increased antimicrobial drug resistance, candidate compounds that specifically target these polypeptides provide therapeutics or therapeutic lead compounds for treating infections caused by drug resistant microbial ... 12/15/05 - 20050277170 - Device and method for detecting antibiotic inactivating enzymes The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present ... 12/15/05 - 20050277169 - Active microcosm: screening antimicrobial producing microorganisms The Active Microcosm approach offers a new method for detecting antimicrobial producing microorganisms in natural samples prior to plating and culture isolation. The method involves inoculating portions of natural substrates; soil, litter, water etc., onto different agar nutrient media contained in the wells of a standard 96-well membrane filter plate. ... 11/17/05 - 20050255538 - Methods for screening for acrab efflux pump inhibitors The invention relates to the field of antimicrobial agents, and to methods for the identification and characterization of potential antimicrobial agents and compounds which enhance the effect of antimicrobial agents. More specifically this invention relates to methods for screening agents for which the mode of action involves the acrAB family ... 11/10/05 - 20050250174 - Method for evaluating antifungal agent A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and ... 11/03/05 - 20050244917 - Device and method for detecting antibiotic inactivating enzymes The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present ... 11/03/05 - 20050244916 - Methods for predicting protein activity based on identification of multidimensional signatures The present invention provides a method for predicting antimicrobial activity of a candidate protein by determining the correlation between a multidimensional antimicrobial signature and a multidimensional antimicrobial signature model. The invention also is directed to a method for identifying a protein having antimicrobial activity by screening a library of candidate ... 10/13/05 - 20050227309 - Optically-detectable enzyme substrates and their method of use The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods ... 09/15/05 - 20050202522 - Method of screening for antimicrobial agents [Solving Means] Using the genomic sequence of a bacterium, FFRPs coded therein are identified on the basis of correlation between FFRPs summarized in a multiple alignment shown in FIG. 1. By specifying chemical compounds that can specifically interact with the identified FFRPs or their assemblies, thereby changing their 3D structures, ... 08/25/05 - 20050186653 - Compositions and methods for screening antibacterial compounds The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention, three two-component systems are described: LiaR & LiaS (formerly YvqCE); YvcP & YvcQ; and BceR & BceS (formerly YtsAB). These systems, ... 07/21/05 - 20050158816 - Aequorin as a growth marker in yeast A yeast cell containing constitutively expressed aequorin and methods of using the cells in growth and toxicity assays are disclosed. ... 06/02/05 - 20050118669 - Novel fluorogenic substrates for beta-lactamase gene expression Fluorescent substrates for beta-lactamases having the general formula shown above are provided. Z includes a fluorophore or chromophore and includes a group that may link to the lactam-containing group; R1 and R2 are independently selected from H, aliphatic, aromatic, alkyl, and acyl; R4 may be H and lower alkyl; B ... 06/02/05 - 20050118668 - Modified acyl carrier proteins Disclosed are apo-, holo-, and acylated-acyl carrier proteins modified to have a non-radioactive label covalently bonded to a modified tyrosine residue within the acyl carrier protein. Also disclosed are methods of using the labeled acyl carrier proteins to investigate reaction involving or mediated by acyl carrier proteins. Also disclosed are ... ### FreshPatents.com Support |