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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Hydrolase > Involving Esterase > Involving Phosphatase Involving PhosphataseInvolving Phosphatase patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/12/07 - 20070082374 - Method of treating a condition associated with phosphorylation of task-1 This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of ... 02/08/07 - 20070031909 - Modulation of protein methylation and phosphoprotein phosphate The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising ... 12/21/06 - 20060286622 - Polypeptides exhibiting pde7 activity and their use for selecting compounds which inhibit pde 7 enzyme activity The present invention relates to polypeptides exhibiting a higher PDE7 phosphodiesterase activity than the endogenous full length PDE7 and their use for selecting compounds which inhibit PDE7 enzyme activity. ... 11/16/06 - 20060257962 - High sensitivity assay for detection of nucleoside diphosphate production The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or ... 11/09/06 - 20060252108 - Direct detection of biomolecules in a gel A method for detecting a target biomolecule directly in a polyacrylamide gel in which it has been separated from other substances. Prior to binding the target to a probe and while the target biomolecule remains in the gel, the gel is immersed in a water miscible aqueous extracting medium containing ... 09/28/06 - 20060216778 - Peptides and methods for deactivation of organophosphorus-based nerve agents and insecticides This invention provides methods and peptides for the inactivation of organophosphorus-based insecticides and chemical warfare agents. The instant methods include peptide screening methods, peptides and peptide libraries, related compositions of matter, articles of manufacture, and methods for prophylaxis, treatment, decontamination and detection. ... 08/31/06 - 20060194271 - Phosphorylation and regulation of akt/pkb by the rictor-mtor complex In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity. ... 06/22/06 - 20060134718 - Assay for camp based on exclusive binding of camp to the b-binding sites of camp dependent protein kinase (capk) The present invention provides a method for assaying for cAMP in a sample, said method comprising contacting a sample with an unknown cAMP content with a polypeptidic cAMP binding agent and optionally with a labelled cAMP and detecting conjugates of cAMP or labelled cAMP and said binding agent, characterized in ... 06/22/06 - 20060134717 - Method for making biochips A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method. ... 06/08/06 - 20060121550 - Modulation of pde11a activity The invention provides genetically modified non-human mammals and genetically modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal ... 05/25/06 - 20060110783 - Diagnostics and therapeutics for diseases associated with human phosphodiesterase 10a (pde10a) The invention provides a human PDE10A which is associated with the disorders of the peripheral and central nervous system (e.g. Alzheimer), cardiovascular diseases, cancer (e.g. thyroid, oesophagus, stomach, liver, ovary, kidney), gastroenterological diseases (e.g. liver cirrhosis), endocrinological diseases and urological diseases (e.g. benign prostate hyperplasia). The invention also provides assays ... 05/04/06 - 20060094074 - Methods for screening and therapeutic applications for kinesin modulators The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated ... 04/27/06 - 20060088900 - Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway The invention is directed to a method for determining the inhibition activity of a compound to be tested on at least the DHPS activity of the folate synthesis pathway, which is coupled with the detection of the release of formed inorganic phosphate. An enzymatic assay, implementing this method of determination ... 03/23/06 - 20060063220 - Charcoal stabilization of phenyl phosphates The invention discloses methods, compositions and kits for stabilizing a solubilized phenyl phosphate, preferably paranitrophenyl phosphate (PNPP), using charcoal. Also disclosed are methods, compositions and kits for recycling solubilized phenyl phosphate, preferably PNPP, that has an absorbance of less than 0.1 when measured at 405 nm due to non-enzymatic hydrolysis. ... 03/09/06 - 20060051830 - Quantitation of enzyme activity using planar waveguides Enzyme activity sensors comprising a planar waveguide can be used for sensitive and quantitative measurement of enzyme activity. Such enzyme activity sensors are useful in a variety of settings, including clinical, commercial, and public health settings. ... 01/19/06 - 20060014231 - Methods and compositions to promote bone homeostasis Methods are disclosed for identifying osteogenic promoting compounds by contacting test compounds with a target gene polypeptide or fragment thereof, which target gene is identified as involved in the osteogenesis process, and measuring a compound-polypeptide osteogenesis property. Also disclosed are methods of promoting osteogenesis by contacting progenitor cells with an ... 12/01/05 - 20050266511 - High throughput sarcomeric assay The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts. ... 11/17/05 - 20050255537 - Method for monitoring treatment with a parathyroid hormone The present invention relates to a method for monitoring effects of administration of a parathyroid hormone by determining levels of one or more markers of an activity of this hormone. Suitable markers of bone formation include one or more enzymes indicative of osteoblastic processes of bone formation, preferably bone specific ... 11/03/05 - 20050244914 - Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis ... 10/27/05 - 20050239159 - Gtp cyclohydrolase ii as as target for fungicides The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II, and also to the use of compounds identified as fungicides via the abovementioned method. ... 10/20/05 - 20050233404 - Methods for the identification of inhibitors of cyclic nucleotide phosphodiesterase as antibiotics The present inventors have discovered that a cyclic nucleotide phosphodiesterase is essential for normal fungal pathogenicity. Specifically, the inhibition of PDE2 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, PDE2 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present ... 10/06/05 - 20050221412 - Probes for imaging protein phosphorylation and dephosphorylation and method for detecting and determining protein phosphorylation and dephosphorylation using the same As a versatile method of detecting and assaying intracellular protein phosphorylation and dephosphorylation that enables nondestructive monitoring as well as spatial and temporal analysis for living cells, animal bodies, plant bodies and the like, a probe for imaging protein phosphorylation and dephosphorylation, which comprises a tandem fusion unit composed of ... 09/29/05 - 20050214888 - Methods of eavaluating phosphatase inhibitors The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be ... 06/16/05 - 20050130250 - Method of diagnosing adolescent idiopathic scoliosis and related syndromes A method for diagnosing an increased risk for a disease characterized by a dysfunctional melatonin-signaling path-way in an animal comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in at least one of the animal's cells, wherein the presence of at least one impairment in ... 06/09/05 - 20050124024 - Charcoal stabilization of phenyl phosphates The invention discloses methods, compositions and kits for stabilizing a solubilized phenyl phosphate, preferably paranitrophenyl phosphate (PNPP), using charcoal. Also disclosed are methods, compositions and kits for recycling solubilized phenyl phosphate, preferably PNPP, that has an absorbance of less than 0.1 when measured at 405 nm due to non-enzymatic hydrolysis. ... 06/09/05 - 20050124023 - Phosphoamidase assay The present invention relates to the use of compounds and to methods for the qualitative and/or quantitative determination of the activity of phosphoamidases or protein phosphoamidases specific for hydrolyzing phosphoamide (P—N) bonds. N-phosphorylated basic amino acids like phospholysine, phosphoarginine and phosphohistidine. ... 06/09/05 - 20050124022 - Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a polypeptide that converts ATP into a detectable entity. Accordingly, this invention focuses on sulfurylase-luciferase fusion proteins. This invention also relates to pharmaceutical compositions ... ### FreshPatents.com Support |