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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Transferase Involving TransferaseInvolving Transferase patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.03/29/07 - 20070072253 - Method of determining standard activity value of nattokinase A method of determining a standard activity value of Nattokinase includes preparing a standard curve with respect to a plurality of Nattokinases having predetermined activity values by calculating corresponding dilution multiples using a standard essay, obtaining a sample curve with respect to an indeterminate Nattokinase by diluting the indeterminate Nattokinase ... 03/22/07 - 20070065892 - High throughput assay of lp-pla2 activity This invention relates to a method for determining the activity of Lp-PLA2 in a plurality of samples from animals. The invention also relates to a kit for determining Lp-PLA2 activity in a plurality of samples. ... 03/08/07 - 20070054343 - Use of thiol-reactive reagents for detecting enzyme activity Disclosed are assays useful for detecting enzyme activity. The assays may utilize thiol-reactive reagents. The assays may include reacting a reacting mixture that contains an ATP analog (e.g., ATPβS or GTPβS) to form an ADP analog (e.g., ATPβS or GTPβS). ... 03/01/07 - 20070048814 - Novel purified dihydrodipicolinate synthase polypeptides and structures thereof The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. ... 02/22/07 - 20070042451 - Glycine decarboxylase complex as a herbicidal target The invention relates to the use of glycine decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to ... 02/01/07 - 20070026477 - Whole cell assay involving cathepsin s The present invention relates to a method of identifying and evaluating chemical inhibitors of cathepsin S activity in whole cells. The present invention also relates to probes that are capable of forming irreversible adducts with cathepsin S at the active site. The probes used in the instant invention comprise radioactive ... 01/11/07 - 20070009979 - Cyclic gmp dependent protein kinase as a chemotherapeutic target for antiprotozoal agents Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents. ... 01/11/07 - 20070009978 - Three part assay for kinase or phosphatase activity The present invention relates to a method of determining kinase or phosphatase activity based on a three parts system. The method comprises contacting a binding partner which can bind phosphorylated peptides, a detection molecule and a substrate peptide. Determination of activities is achieved by measuring energy transfer between an energy ... 01/11/07 - 20070009977 - Kinase-directed, activity-based probes Various embodiments of the present invention are related to kinase-directed, activity-based probes (“KABPs”) that bind to, and label, kinases. Each KABP includes a binding group that is recognized and bound by one or more kinases, a reactive group that tightly, and generally irreversibly, binds to the kinase, a tag group ... 12/28/06 - 20060292654 - Microwell plate The shallower wells of a crystalisation plate in which it is intended to form crystals are part-spherical and of uniform wall thickness. The optical effect of the transparent plastics material from which the plate is moulded counter the distortion of a view through a microscope so that crystals viewed through ... 12/28/06 - 20060292653 - Metal mediated fluorescence superquenching assays for detection of phosphorylation and dephosphorylation of quencher-labeled substrates A method includes contacting an analyte; a phosphorylatable or dephosphorylatable substrate bound to a quencher; and a sensor that includes at least one fluorescent polymer complexed to one or more metal species; to form a composition; and determining the fluorescence of the composition, if any; wherein when the substrate is ... 12/28/06 - 20060292652 - Substrate detection assay Methods and compositions for evaluating nicotinamide-releasing activities as well as cell and organism-based evaluation methods are provided herein. ... 12/28/06 - 20060292651 - Protein labelling with oº-alkylguanine-dna alkyltrnsferase The present invention relates to methods of transferring a label from suitable substrates to O6-alkylguanine-DNA alkyltransferase (AGT) fusion proteins, to suitable fusion proteins, to suitable variants of AGT, and to novel labelled fusion proteins obtained. A protein of interest is incorporated into an AGT fusion protein, the AGT fusion protein ... 12/07/06 - 20060275855 - Enzyme array and assay The present invention relates to an enzyme array and assay for use with a mass spectrometer, particularly, though not exclusively, a laser desorption/ionisation, such as a MALDI mass spectrometer. It includes a method of determining the activity of an enzyme, or the effect a test compound has on the activity ... 11/23/06 - 20060263841 - Fluorescent probes for use in protein kinase inhibitor binding assay The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound ... 11/23/06 - 20060263840 - Method for rapid determination of thiopurine methyltransferase activity This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination of TPMT activity in biological samples. ... 11/16/06 - 20060257960 - Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform ... 10/19/06 - 20060234328 - Anthrax lethal factor is a mapk kinase protease The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells. ... 10/19/06 - 20060234327 - Methods for identifying enzyme inhibitors and protein kinases The present invention provides methods for identifying compounds that inhibit kinases. In addition, methods for profiling protein kinases are also provided. In addition, methods for determining the mode of action of kinase inhibitors are also provided. ... 10/19/06 - 20060234326 - Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels The present invention provides a method for detecting a metabolic disorder in an individual. The method involves (a) contacting a sample containing (i) one or more metabolically indicative enzymes and (ii) one or more metabolic analytes, with one or more substrates for said one or more enzymes to produce a ... 10/12/06 - 20060228766 - Assay for detection of transferase enzyme activity in drug screening The invention provides methods for assaying the activity of the translocase enzyme and/or transferase enzyme involved in peptidoglycan biosynthesis in bacteria using scintillation proximity assay methodology. The methods are suitable for high throughput screening of potential anti-bacterial drugs. ... 09/28/06 - 20060216776 - Screening assay for agents that alter target of rapamycin activity The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by TOR. Naturally occurring TOR which may be used in the methods of the ... 09/28/06 - 20060216775 - Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes This invention generally relates to methods and compositions for identifying a protein of interest. The compositions further provide microarrays. The methods provide a viable screen for genetic and proteornic events in natural and engineered systems. ... 09/28/06 - 20060216774 - Method A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro ... 09/21/06 - 20060211075 - Enzyme sensors including environmentally sensitive or fluorescent labels and uses thereof Sensors for detecting enzyme activity are provided. The sensors include substrate modules having environmentally sensitive labels and detection modules whose binding to the substrate modules results in changes in signals from the environmentally sensitive labels or polypeptides or polypeptide substrates including environmentally sensitive or fluorescent labels. Compositions including substrate modules, ... 09/21/06 - 20060211074 - Kinase-directed, activity-based probes Various embodiments of the present invention are directed to kinase-directed, activity-based probes (“KABPs”) that tightly bind to, and label, kinases. Each KABP includes a binding group that is recognized and bound by one or more kinases, a reactive group that tightly, and generally irreversibly, binds to the kinase, a tag ... 09/21/06 - 20060211073 - Assay for b-raf activity based on intrinsic mek atpase activity The present invention provides a convenient assay to identify compounds with B-Raf inhibitory activity, referred to as the BRAMA (B-Raf Accelerated MEK ATPase) assay. The BRAMA assay is based on the discovery of ATPase activity of MEK, and utilizes changes in NADH concentration over time as an indicator of the ... 09/14/06 - 20060205027 - Alkylguanyltransferase assays This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring ... 09/14/06 - 20060205026 - Parallel inducible cell-based kinase screen A parallel inducible cell-based kinase screen (PICKS) includes a plurality of cells that express a kinase gene under the control of an inducer and a reporter gene, wherein the cells are derived from a single cell line, and wherein the reporter gene generate a signal in response to catalytic activity ... 08/24/06 - 20060188952 - Homogeneous fluorescence assay for kinases, phosphatases, and phosphodiesterases The present invention relates to a homogeneous assay method of quantitative measurement of kinase, phosphatase and phosphodiesterase (PDE) reactions. The method may be used both in a direct and in a competitive assay format. ... 08/03/06 - 20060172362 - Methods and compositions for assaying homocysteine This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion ... 08/03/06 - 20060172361 - Assay for detection of translocase enzyme activity in drug screening The invention provides a method for assaying the activity of the translocase enzyme involved in peptidoglycan biosynthesis in bacteria using scintillation proximity assay methodology. The method is suitable for high throughput screening of potential anti-bacterial drugs. ... 08/03/06 - 20060172360 - Mkk7 activation inhibitor PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun ... 07/27/06 - 20060166300 - Method of measuring homocysteine A method for detecting or measuring homocysteine in a sample includes the steps of (a) reacting a D-amino acid present in a sample with a D-amino acid converting enzyme to convert the D-amino acid into a substance that does not serve as a substrate of D-amino acid oxidase or D-amino ... 07/06/06 - 20060148020 - Inhibitors of gst a3-3 and gst a1-1 for the treatment of cancer The present invention relates to a novel drug target, glutathione transferase (GST), preferably GST A3-3, as target for treatment of cancer and other diseases responsive to inhibition of steroid hormone production. The present invention also relates to a method for screening of compounds or drug candidates that modulate, preferably inhibit, ... 06/29/06 - 20060141550 - Novel metabolic targets and markers The present invention provides metabolic markers and targets, especially PEMT activity and metabolic markers and components associated therewith useful for diagnosing and treating various disease conditions. ... 06/29/06 - 20060141549 - Cell-based kinase assay The present invention relates to improved systems and strategies for the investigation of kinase activity in cells. More specifically, cell-based assay methods are provided that allow the phosphorylating activity of a kinase to be determined inside a cell. The invention also provides cell-based screening assays for identifying compounds that have ... 06/22/06 - 20060134714 - Detection and identification of peptide and protein modifications Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diagnosis, ... 06/01/06 - 20060115870 - High throughput assay for human rho kinase activity The present invention provides a high throughput assay for human Rho kinase activity in vitro, and methods and kits therefor. A high throughput method of assaying a test compound for human Rho kinase modulating activity is also provided. ... 06/01/06 - 20060115869 - Uses of carbamoyl phosphate synthetas for the diagnosis of inflammatory diseases and sepsis Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of ... 05/18/06 - 20060105414 - Inhibition of b-cell maturation and antibody production The present invention provides methods and compositions for the inhibition of B-cell maturation and antibody production without interfering with innate or T-cell mediated immunity. ... 05/18/06 - 20060105413 - Rick3 nucleic acids and proteins The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-κB signaling. The present invention thus provides novel targets for drug screening ... 04/20/06 - 20060084129 - Novel ways of assessing metabolic processes The present invention provides methods for assessing contribution of one or more pathways to the biosynthesis of a metabolite, e.g., a lipid using the levels of the product made and the metabolite precursors for each pathway. ... 04/20/06 - 20060084128 - Enzyme assay with nanowire sensor Systems and methods for enzyme assay using nanowire sensor are disclosed. In some embodiments, a substrate and a group suitable for assaying a target enzyme are identified. The selected substrate is immobilized to a nanowire. The target enzyme introduced to the immobilized substrate modifies the substrate to facilitate addition or ... 03/30/06 - 20060068456 - Methods for screening and identifying compounds The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes, diabetes-related disorders, obesity, cardiovascular disease, cancer, and other diseases or ... 03/30/06 - 20060068455 - Gaba detection methods and applications Disclosed herein are silica glass sensors comprising more than one active biological material in a single sol-gel layer. The silica glass sensors may be used to assay complex biological mechanisms in cells and tissues cultivated thereon. Also disclosed are silica glass sensors having GABA-T, SSADH, or both, for detecting GAD, ... 03/23/06 - 20060063219 - Trivalent metal mediated homogeneous luminescent proximity assay An in vitro protein kinase assay technology that (1) exhibits a high assay signal to background ratio (S/B) and range (S-B); (2) is homogenous; (3) is non-radioactive; and (4) does not require a phospho-specific antibody involves complexing a trivalent metal ion (e.g. Ga3+, Fe3+, Al3+, In3+, Ru3+, Sc3+, Y3+) to ... 03/16/06 - 20060057658 - Labeled substrate conjugates for identifying enzyme inhibitors This invention provides labeled-substrate conjugates for assaying enzymes, particularly neuraminidases. Also provided are assays that are useful for identifying compounds that inhibit sialyltransferases or neuraminidases and may be useful in treating subjects with influenza. In particular, the present invention relates to methods of using such labeled substrate conjugates to screen ... 03/09/06 - 20060051829 - Regulating pas domain function with foreign pas ligands A functional surface binding specificity of a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is changed by (a) introducing into the hydrophobic core of the PAS domain a foreign ligand ... 03/02/06 - 20060046277 - Protein kinase and phosphatase substrates and multiplex assays for identifying their activities The present invention provides protein kinase and protein phosphatase substrates, methods of detecting protein kinases and protein phosphatases, and kits for detection of protein kinases and protein phosphatases. The substrates, methods, and kits use multiple substrates that can easily be differentiated from all other substrates, thus enabling rapid and easy ... 02/16/06 - 20060035303 - Jnk3 modulators and methods of use The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response ... 02/16/06 - 20060035302 - Kinase substrates with multiple phosphorylation sites Disclosed are fluorescent compositions and methods for detecting and/or characterizing enzymes and various uses thereof. ... 02/16/06 - 20060035301 - Method of identifying protein kinase modulators and uses therefore Methods of identifying AMPK or AK modulators are provided. In particular, methods that feature identifying modulators of AK and its associated substrates (including AMP, ATP or AMP and ATP) or AMPK or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are ... 02/02/06 - 20060024775 - Substrates for o6-alkylguanina-dna alkyltransferase The present invention relates to methods of transferring a label from novel substrates to O6-alkylguanine-DNA alkyltransferases (AGT) and O6-alkylguanine-DNA alkyltransferase fusion proteins, and to novel substrates suitable in such methods. Proteins of interest are incorporated into an AGT fusion protein, the AGT fusion protein is contacted with particular AGT substrates ... 12/22/05 - 20050282239 - Cell-permeable enzyme activation reporter that can be loaded in a high throughput and gentle manner A membrane traversing peptide conjugate comprises (i) a label, (ii) a target peptide, attached to the label, and (iii) a transduction domain, attached to the target peptide. The target peptide is a reactant for a chemical reaction occurring in a cell. ... 12/01/05 - 20050266510 - T cell anergy is reversed by active ras and regulated by diacylglycerol kinase T cell anergy has been correlated with defective Ras signaling. However, neither a causal relationship nor the mechanism of Ras hypoactivation have been established. Using adenoviral transduction of CAR Tg T cells to enable genetic manipulation in nonproliferating cells, we show that Ras61L restores IL-2 production and MAP kinase signaling ... 12/01/05 - 20050266509 - Interaction of nmda receptor with protein tyrosine phosphatase The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and the protein tyrosine phosphatase PTPMEG. The present invention provides methods for screening a PTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provides methods and compositions for treatment of disorders mediated ... 11/10/05 - 20050250167 - Purified pkb ser 473 kinase and uses thereof This invention provides purified PKB Ser 473 kinase and methods of purifying it. The methods involve the use of several sequential steps, including subcellular fractionation to isolate a plasma membrane fraction and the use of gel filtration or chromatography that separates molecules according to their size or affinity. ... 11/10/05 - 20050250166 - Cdc7-ask kinase complex, substrates of the kinase complex, antibody specific to the substrate, and method of screening compound capable of inhibiting cdc7-ask kinase using the same The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex ... 11/03/05 - 20050244911 - Methods and reagents for treating autoimmune disorders The present invention provides methods and reagents for identifying compounds to treat autoimmune diseases. ... 10/27/05 - 20050239157 - High throughput screen for inhibitors of fatty acid biosynthesis in bacteria Methods for identifying compounds that are inhibitors of bacterial fatty acid biosynthesis are disclosed. Such compounds can be used as lead compounds in methods for preparing antibacterial agents for treating bacterial infections (e.g., in humans, animals, and plants). Inhibitors of bacterial fatty acid synthesis can also be tested for their ... 10/20/05 - 20050233401 - Specificity and activity assay for phospholipid transfer proteins and method for identification and characterization of diseased states Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the presence of suitable osmotic pressure. ... 10/13/05 - 20050227305 - Methods for the identification of inhibitors of adenylosuccinate synthase as antibiotics The present inventors have discovered that adenylosuccinate synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of adenylosuccinate synthase gene expression in fungi results in drastically reduced pathogenicity. Thus, adenylosuccinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides ... 10/06/05 - 20050221411 - Interaction of nmda receptor with the protein tyrosine phosphatase step in psychotic disorders The present invention relates to the identification of STEP being as involved in signaling pathways relating to psychotic diseases, including schizophrenia, and other disorders in which NMDA receptor dysfunction is implicated. The present invention provides methods for screening STEP inhibitors that modulate NMDA-R signaling. The present invention also provides methods ... 10/06/05 - 20050221410 - Scintillation proximity assay method of measuring acetyl coa carboxylase enzyme activity The present invention relates generally to enzyme assays and more particularly to a rapid, sensitive, reliable and robust homogeneous assay for acetyl CoA carboxylase activity comprising a coupled enzyme assay in a scintillation proximity format suitable for high-throughput screening. In one aspect, the assay couples ACC and FAS and the ... 10/06/05 - 20050221409 - Methods for the identification of inhibitors of amidophosphoribosyltransferase as antibiotics The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the ... 09/29/05 - 20050214887 - Method for analyzing residual agricultural chemical The present invention relates to a method for analyzing residual agricultural chemicals which comprises the steps of acting a reduced glutathione as a reactive substrate and a glutathione transferase serving as a catalyst for the reaction on a carbofuran derivative or a methomyl derivative as a carbamate type agricultural chemical ... 09/29/05 - 20050214886 - Tnf modulation Modulators such as proteins, peptides, antibodies or analogs, fragments or derivatives of any of them are provided which are capable of interacting with, or binding to, the intracellular domain of the membrane-bound form of TNF (26 KD TNF). These modulators are capable of regulating the expression, proteolytic processing, bioactivity or ... 09/29/05 - 20050214885 - Method for detecting mild impaired glucose tolerance or insulin hyposecretion It is intended to provide a noninvasive method of conveniently detecting mild impaired glucose tolerance and/or insulin hyposecretion at the early stage with the use of an enzyme. Namely, mild impaired glucose tolerance and/or hyposecretion at the early stage are detected by quantifying myoinositol secreted into the urine before loading ... 09/22/05 - 20050208612 - Transglutaminase has intrinsic kinase activity A method of identifying compounds capable of modulating trans-glutaminase (TG) kinase activity is described. The method involves adding a test compound to a mixture of TG and a suitable TG kinase substrate, incubating the mixture under conditions promoting TG kinase activity, and determining if the test compound activates or modulates ... 09/22/05 - 20050208611 - Process for identifying compounds with fungicide activity based on ump/cmp kinases from fungi The invention refers to a process for identifying fungicides, the use of a UMP/CMP kinase for identifying fungicides, as well as nucleic acids coding for UMP/CMP kinases and the polypeptides coded by them. ... 09/15/05 - 20050202519 - Mutated abl kinase domains The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, ... 09/08/05 - 20050196822 - Anthrax lethal factor is a mapk kinase protease The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells. ... 09/01/05 - 20050191718 - Methods for measuring phosphatase activity A method for determining the level of kinase activity or phosphatase activity in a sample without the use of antibodies or radioactive labels is disclosed. The method employs a fluorescently-labeled phosphorylatable reporter peptide that is capable of being cleaved by a protease only when the peptide is in an unphosphorylated ... 07/28/05 - 20050164323 - Methods of treating asthma Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC-θ protein, as well as for agents that inhibit the kinase activity of a PKC-θ protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. ... 07/07/05 - 20050148042 - Hybrid phosphoinositide phospholipids: compositions and uses The methods and compositions disclosed herein concern the synthesis of a novel class of “two-headed” phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those ... 06/30/05 - 20050142630 - Interaction of nmda receptor with the protein tyrosine phosphatase step in psychotic disorders The present invention relates to the identification of STEP being as involved in signaling pathways relating to psychotic diseases, including schizophrenia, and other disorders in which NMDA receptor dysfunction is implicated. The present invention provides methods for screening STEP inhibitors that modulate NMDA-R signaling. The present invention also provides methods ... 06/30/05 - 20050142629 - Identification of active-site inhibitors of glycosyltransferases using a generalizable high-throughput screen A method is described for identifying a compound that modulates the ability of a glycosyltransferase to bind a substrate comprising combining a glycosyltransferase, a labeled substrate, and a compound, in a reaction vessel, under conditions known to be suitable for the glycosyltransferase to bind the labeled substrate, measuring an amount ... 06/02/05 - 20050118663 - Methods and compositions for modulating cell proliferation This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating ... ### FreshPatents.com Support |