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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay > Assay In Which An Enzyme Present Is A Label > Heterogeneous Or Solid Phase Assay System (e.g., Elisa, Etc.) > Competitive Assay Competitive AssayCompetitive Assay patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.03/08/07 - 20070054341 - Immunoassay and reagents and kits for performing the same A sandwich immunoassay is disclosed that provides simple to perform yet sensitive identification of analytes in samples. All assay constituents needed (except analyte to be detected) for one assay are dried. Upon reconstitution with sample, a 10 to 15 minute incubation gives a rapid and convenient detection assay capability. The ... 01/11/07 - 20070009976 - Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody The present invention relates to the field of therapeutic antibodies. The invention especially relates to a method of detecting the target antigen of a therapeutic antibody in a sample comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with said therapeutic antibody under conditions ... 12/07/06 - 20060275853 - Methods to increase dynamic range and improve quantitative analysis in rapid biosensors Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to have both low end and high end sensitivity. Also described is a conductimetric assay device having a pre-capture zone ... 12/07/06 - 20060275852 - Assays based on liquid flow over arrays Cassette (50) performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (50), flowing over wide array (20) of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10−1 to 5×10−3, are heated in region (34) ... 12/07/06 - 20060275851 - Layered peptide/antigen arrays - for high-throughput antibody screening of clinical samples A method and composition for the identification of biomolecule in a sample are disclosed. The method comprises obtaining a coated capture membrane stack comprising a plurality of capture membranes with each capture membrane coated with a different peptide. The membrane stack is exposed to a sample, and, after a given ... 11/23/06 - 20060263837 - Immunoassay system and method for detection of antigens The present invention provides a system and method for detecting antigens without discrimination between antigens. The present invention further provides a diagnostic kit for detecting markers derived from a disease or clinical samples. ... 11/16/06 - 20060257958 - Magnetically-assisted test strip cartridge and method for using same The present invention provides a small (business card-sized) disposable mesofluidic or microfluidic plastic cartridge containing several straight microchannels potentially filled with culture media, solubilizing reagents (e.g., detergents) nitrocellulose paper strip, gel or other matrix materials and lyophilized paramagnetic microbeads or microparticles coated with antibodies, nucleic acid aptamers, oligonucleotides, or other ... 11/02/06 - 20060246526 - Microfluidic affinity assays with improved performance Method for measuring the signal from a label in a labeled measuring reagent that has been specifically adsorbed to its affinity counterpart in a zone of a porous nanolitre (nl) bed that is present in a microchannel structure of a microfluidic device. The measuring is part of an assay for ... 11/02/06 - 20060246525 - Method of screening remedy for heart disease and medicinal composition for treating heart disease A method for screening a substance that inhibits the onset of anti-cardiac troponin I autoantibody-related disease, a pharmaceutical composition and a base material for therapy of cardiac disease that contains the substance obtained by aforesaid method thereof, a therapeutic apparatus that removes anti-troponin I autoantibody for aforesaid antibody related disease, ... 10/26/06 - 20060240498 - Devices and methods for detecting amniotic fluid in vaginal secretions The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies. ... 09/28/06 - 20060216772 - Interfacial biomaterials for binding metal substrates An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including ... 08/31/06 - 20060194270 - Method for measuring oxidized ldl-crp complex and measurement kit The present invention provides a method for measuring a “complex of oxidized LDL and CRP” which comprises using an “anti-CPR antibody”. An “anti-apoB antibody and/or anti-β2-GPI antibody” is preferably used in the method of the present invention, which preferably comprises at least a step for forming a sandwich complex represented ... 08/17/06 - 20060183176 - Method and reagent for detecting cell death A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C ... 07/20/06 - 20060160164 - Immunoassay device with immuno-reference electrode An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the ... 07/20/06 - 20060160163 - Method of saying alastin digestion product and assay kit, method of detecting aortic dissection and detection kit An immunoassay method for conveniently and accurately measuring amount of the elastin degradation product in a circulating fluid of a subject, which is useful for detection of aortic dissection, the method comprising immunologically binding a first antibody and a second antibody to the elastin degradation product, wherein the first antibody ... 06/01/06 - 20060115867 - Trim 5 related protein as a biomarker of neurodegenerative disease The present invention relates to a biomarker for neurodegenerative disease, including amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), and Parkinson's (PD) disease. More particularly, the present invention relates to the identification of a tripartite motif protein TRIM5 isoform gamma related protein as a biomarker useful for the detection, diagnosis, and differentiation ... 06/01/06 - 20060115866 - Immunoassay method and kit to be used therein Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the competitive substance than for the target substance, a specimen is treated with these two antibodies. Then, the competitive ... 05/18/06 - 20060105411 - Method of detecting early pregnancy at high accuracy by measuring hcg and hyperglycosylated hcg concentrations equally The present invention relates to methods for analyzing concentrations of hyperglycosylated hCG (H-hCG) and hCG equally in blood, serum or urine samples, preferably urine samples, from female patients to determine with an unexpectedly high measure of accuracy whether or not the patient is pregnant and to appropriately monitor hCG levels ... 03/09/06 - 20060051825 - Methods and compositions for measuring canine bnp and uses thereof The present invention describes compositions and methods designed to determine the presence or amount of BNP or fragments thereof in a sample. In particular, the invention provides materials that may be configured to bind canine BNP in a sandwich assay format. The present invention provides, inter alia, assays designed to ... 02/16/06 - 20060035297 - Reagents and methods for mycophenolic acid immunoassay The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to MPA with cross-reactivity of no more ... 02/09/06 - 20060029990 - Method for diagnosing inflammatory diseases and infections by the determination of lasp-1 immunoreactivity Method for early diagnosis and diagnosis, for prognosis and assessment of the severity and for therapy-accompanying monitoring of inflammatory diseases and infections, in particular sepsis-like systemic infections and Alzheimer's disease, in which the presence and/or amount of the protein LASP-1 (SEQ ID NO:1) or of the protein LAP-1 (SEQ ID ... 02/02/06 - 20060024771 - Enhancement of sensitivity of fluorophore mediated biosensing and bioimaging A method of enhancing fluorescence emission in a fluorophore-mediated sensing, biosensing, imaging, and bioimaging. An example of biosensing is a fluorophore-mediated sandwich immunoassay with a 1° monoclonal antibody against a target analyte and a fluorophore-linked 2° monoclonal antibody, exposing the immunoassay to an enhancing agent, applying excitation light to the ... 12/22/05 - 20050282238 - High-sensitivity chemiluminescent elisa prion detection method A high-sensitivity chemiluminescent ELISA-based prion detection method is provided, the method comprising an ELISA plate coated with monoclonal antibody for the capture of PrPsc protein and treated with an optimized blocking reagent, and a set of labeling and detection reagents. The digestion cocktail is preferably a unique combination of proteolytic, ... 12/08/05 - 20050272110 - Supersensitive immunoassays An assay exhibiting improved sensitivity for achieving a factor of ten times (10×) better sensitivity than current sensitivity levels achieved by prior-art immunoassays, as exemplified by ELISA. Three main implementations are described: IA/MPD, Super-ELISA and Reverse Geometry Immunoassay, including specific panel biomarker relationships for the early detection and recognition patterns ... 12/01/05 - 20050266507 - Antibody pair screening methods The invention provides methods for identifying antibody preparations that can form a pair of antibodies that optimally detect a target antigen, for example, in a sandwich immunoassay. These methods provide high affinity and epitope-specific antibodies. ... 12/01/05 - 20050266506 - Method for diagnosing or monitoring carbohydrate metabolism disorders This invention provides a method for diagnosing geriatric diseases associated with insulin resistance, such as type II diabetes, at an early stage and a method for monitoring the therapeutic effects of agents for type II diabetes by quantitatively assaying GBP28 with the use of a monoclonal antibody that can assay ... 11/24/05 - 20050260695 - Methods, compositions, devices, and kits for detecting mastitis The present invention includes compositions, kits and methods useful for the detection of mastitis in an animal. These agents and methods are primarily directed to a method of detecting the presence of mastitis, including sub-clinical mastitis, in cows, involving incubating a sample of milk from the cow with an agent ... 11/03/05 - 20050244906 - Detection kit, assay plate to be used therein, detection method, evaluation method, polyclonal antibody of frog vitellogenin and process for producing the same On a surface of a well previously disposed on a plate, a primary antibody that recognizes vitellogenin is solid-phased, in the well a sample obtained from a test body exposed to an environment is injected to react, followed by injecting a secondary antibody that is labeled with an enzyme and ... 10/27/05 - 20050239151 - Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form ... 10/27/05 - 20050239150 - Method for diagnosing sepsis by determining anti-asialogangliside antibodies The invention relates to a method for the early detection and detection, the progression prognosis and the evaluation of the degree of severity, and the treatment-accompanying progression evaluation of sepsis and sepsis-like systemic infections, and for the estimation of the danger which would be presented to patients at high risk ... 10/06/05 - 20050221408 - Compositions and methods for detection of single molecules The invention relates to compositions and methods for analyzing polymers such as proteins and their interactions with other molecules, including measuring affinity and kinetic constants. ... 10/06/05 - 20050221407 - Method for detecting lysosomal storage diseases A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay ... 09/29/05 - 20050214883 - Novel alanine transaminase enzyme and methods of use A novel alanine transaminase gene (ALT2) is isolated from human tissue. ALT2 specific polynucleotides, polypeptides, and antibodies are described. ALT2 is expressed predominately in liver, kidney, brain, muscle, and adipose tissue. ALT2 can be used to diagnose injury and diseases involving tissues expressing ALT2. ... 09/08/05 - 20050196819 - Methods and compositions to lower plasma cholesterol levels A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol is provided that includes assessing the ability of the compound to form a complex with the lipoprotein, e.g., LDL or VLDL, and then determining ... 09/08/05 - 20050196818 - Antibodies to alpha-synuclein The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes. ... 08/25/05 - 20050186647 - Methods for identifying or monitoring a patient with increased risk of cardiovascular calcification The present invention includes novel methods of using a calcification risk index (CRI) for identifying or monitoring a patient with increased risk of cardiovascular calcification and/or mortality, or monitoring an effect of therapeutic treatment for a patient having cardiovascular calcification or with increased risk of cardiovascular calcification. The methods may ... 08/11/05 - 20050176081 - Detection of specific nitrated markers Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to ... 08/04/05 - 20050170446 - Sandwich assay and kit A sandwich assay method for detecting the presence of a target molecule in a sample comprising a complex biological fluid is provided. The assay comprises providing a first affinity ligand with affinity for the target molecule, which affinity ligand is capable of being immobilized to a solid support; applying the ... 07/21/05 - 20050158812 - Kits and methods for autoantibody detection An immunoassay method and test kit for detecting autoantibody in a patient sample, such as autoantibodies that interferes with the complexation of intrinsic factor with vitamin B12. A labeled receptor, i.e., intrinsic factor, is mixed with the sample and then with an anti-intrinsic factor antibody that binds competitively with the ... 07/14/05 - 20050153382 - Biochip kit comprising biochip based on antigen-antibody reactions, and its usage This invention concerns a biochip kit, comprising at least one biochip with at least one reactor, in which probe antibody and probe antigen are immobilized non-randomly in the form of probes array or/and probes pattern. This invention also concerns a method for testing a biological sample by using the kit. ... 07/07/05 - 20050148041 - Sandwich assay kits for detecting shigatoxin ctx3c A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of the antibodies is labeled and each of them binds specifically to a ... 06/16/05 - 20050130247 - Rapid prion-detection device, system and test kit Test devices, systems, and test kits are provided for rapid detection with high specificity of the pathogenic form of prion protein responsible for neurodegenerative diseases affecting humans and animals, such as transmissible spongiform encephalopathy in bovine, sheep, and cats. The present invention is also useful for testing animal feedstock made ... 06/16/05 - 20050130246 - Detecting human anti-therapeutic antibodies The invention provides a method for detecting the presence of anti-therapeutic antibody antibodies in a patient being treated with a therapeutic antibody. In one aspect of the invention, the invention is implemented by the following steps: (i) providing a first therapeutic antibody having a molecular tag attached thereto by a ... ### FreshPatents.com Support |