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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay > Assay In Which An Enzyme Present Is A Label > Heterogeneous Or Solid Phase Assay System (e.g., Elisa, Etc.) Heterogeneous Or Solid Phase Assay System (e.g., Elisa, Etc.)Heterogeneous Or Solid Phase Assay System (e.g., Elisa, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087396 - Method of tacrolimus extraction and quantification using aqueous detergents The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the ... 04/05/07 - 20070077608 - Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids. ... 04/05/07 - 20070077607 - Novel screening method The present invention provides a method for identifying a drug-like compound, or lead compound for the development of a drug-like compound, which is capable of modulating cellular adhesion and/or cell survival comprising the step of testing said compound for an ability to modulate the binding of a complex of tissue ... 03/29/07 - 20070072252 - Method for the in vitro titration of an ncta application thereof in a method for the evaluation and/or monitoring of a biological product production method The invention relates to a method for the in vitro titration of a non-conventional transmissible agent (NCTA), using transgenic cell lines. The invention also relates to: the application of the aforementioned in vitro titration method in a method for the in vitro evaluation and/or monitoring of the effectiveness of a ... 03/15/07 - 20070059787 - Kinase and phosphatase assays Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the ... 03/15/07 - 20070059786 - Chemiluminescence enhancer The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a ... 03/08/07 - 20070054340 - Method and antibodies for detecting nitrofuran An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies ... 03/08/07 - 20070054339 - Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... 03/08/07 - 20070054338 - Single receptor assays for immunosuppressive drugs A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate ... 03/08/07 - 20070054337 - Nanoparticle conjugates and method of production thereof The present invention relates to a nanoparticle conjugate comprising a nanoparticle conjugated to a plurality of peptides of a substantially similar amino acid sequence, a peptide conjugated to the nanoparticle by means of a Cysteine (C) residue and the nanoparticle conjugate further comprising a ligand attached to the peptide and ... 02/22/07 - 20070042449 - Method of detection in homogeneous phase, especially of progesterone in mammals' milk, and corresponding kit Method for the qualitative and semi-quantitative detection of a ligand in a sample of a medium to be tested, by (1) diluting at least one lyophilised reaction medium in said sample, (2) incubating the sample in order to carry out an immunoenzymatic method, and (3) observing the resulting colouration. ... 02/15/07 - 20070037233 - Detection of preharvest sprouting in cereal grains A two-site immunoassay for the qualitative or quantitative detection of alpha-amylase in a test sample, said immunoassay comprising; (i) exposing said test sample to a first (“capture”) antibody or fragment thereof which specifically or preferentially binds to a first epitope on said alpha-amylase, under conditions permitting binding of said first ... 02/15/07 - 20070037232 - Detection of ngal in chronic renal disease Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time is disclosed. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and ... 02/08/07 - 20070031908 - Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection reagents The invention relates to a method for detecting progressive, chronic dementia diseases or a predisposition to such diseases or method for the prognosis of such diseases. For this purpose, the concentration of particular peptides in body fluids or other samples from the patient is measured in a method which can ... 02/08/07 - 20070031907 - Anaplastic lymphoma kinase assay, reagents and compositions thereof Disclosed are methods for detecting ALK tyrosine kinase activity and for the identification of compounds that modulate ALK activity, peptide substrates, reagents and compositions thereof. ... 02/01/07 - 20070026475 - Kinase and phosphatase activity measurement using fluorescent polarization A method for quantitating enzyme activity that causes phosphorylation or dephosphorylation of a peptide or protein substrate is provided. The method utilizes the differences in fluorescence polarization of a phosphorylated amino acid-containing fluorescence-emitting reporter molecule free in solution as compared to being bound to a binding molecule. ... 01/25/07 - 20070020713 - Antibodies to the fuel oxygenate mtbe and use thereof in immunoassays Immunoassay of methyl tert-butyl ether (MTBE) and related fuel oxygenates and their breakdown products is performed using a monoclonal antibody produced using a hapten with a CH3—O—C(CH3)2—CH2-moiety, preferably CH3—O—C(CH3)2—(CH2)3—CH(CH3)—CH2—CHO conjugated to a carrier protein. ... 01/18/07 - 20070015228 - Assay for antibodies The presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample can serve as an important clinical or other analytical or diagnostic tool. ELISA methods, and kits for such assays, as well as anti-idiotypic antibodies and hybridomas producing them, are developed to detect levels ... 01/18/07 - 20070015227 - Non-invasive enzyme screen for tissue remodeling associated conditions Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions. ... 01/04/07 - 20070003992 - Methods and kits for detecting cerebrospinal fluid in a sample The present invention relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample, in particular to the analysis of the CSF protein lipocalin-type prostaglandin D2 synthase (L-PGDS). The present invention provides assays for the analysis of PGDS indicating the presence or absence of CSF in ... 12/28/06 - 20060292649 - Methods and apparatus for reference lab diagnostics Automated protein assay apparatus and methods suitable for use in a reference lab are described. A screening test for a pathogen or disease condition is performed at the reference lab. If the results of the screening test are positive, a definitive assay is performed. One or more analytes are resolved ... 12/21/06 - 20060286617 - Ptx3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the determination of PTX3 from plasma or blood. ... 12/21/06 - 20060286616 - Menopause stage monitor The present invention provides a portable menopausal phase monitor with which subjects can learn if they are menopausal, and if so, which phase they are at by using a body fluid such as urine, blood, or the like, as a test sample. A menopausal phase monitor of the present invention ... 12/21/06 - 20060286615 - Novel non-invasive marker for liver function and disease A monoclonal antibody or fragment thereof, capable of specifically binding to at least one epitope of sH2a and/or being elicited by at least one epitope, and assays, kits, and methods of use thereof diagnosing liver disease or condition, detecting liver function and assessing the efficacy of therapy to a liver ... 12/21/06 - 20060286614 - Method for monitoring coagulability and hypercoagulable states The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing effectiveness of anticoagulant therapy. A sEPCR ELISA assay is particularly useful for this purpose. A state of hypercoagulability in patients ... 12/07/06 - 20060275850 - Immunological assay and antibodies for anti-mullerian hormone The present invention discloses compositions and methods to measure an amount of Anti-Mullerian Hormone (AMH) in a sample, including a mammalian sample such as a primate, rodent, equine, or bovine sample. The compositions and methods herein also provide antibodies that bind to epitopes on AMH that are stable to proteolysis ... 12/07/06 - 20060275849 - Monoclonal antibody reagents Methods for purifying monoclonal antibody reagents having increased sensitivity or increased specificity for use in immunoassays for a particular analyte and assays using such antibody reagents. The monoclonal antibody reagents are prepared by serial elution of the monoclonal antibody purification lots at different pHs. ... 11/30/06 - 20060269977 - Recombinant antibody recognizing dioxin and gene encoding the antibody The present invention relates to a novel recombinant antibody having a binding activity to 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF), a gene encoding its amino acid sequence, a vector incorporating said gene, a transformant transformed with said vector, a process for preparing said recombinant antibody, and methods for immunologically capturing and determining 2,3,4,7,8-PeCDF using ... 11/23/06 - 20060263836 - Composition for homogeneous multiplexed microparticle-based assay A method and composition for the purpose of detecting and measuring analytes, such as antibodies, which are capable of binding with certain binding partners such as antigens. A homogenous assay is performed in the presence of free unbound antibodies. Such a homogeneous assay testing for specific antibodies is herein possible ... 11/23/06 - 20060263835 - Identification of agonistic autoantibodies The invention relates to a method for detecting disease-associated autoantibodies, which recognize extracellular structures of G protein-coupled receptors, and to the use of peptides, which comprise these loops or fragments thereof, for treating autoimmune diseases. ... 11/16/06 - 20060257957 - Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin a complexes in a blood sample The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed in the blood of a drug-treated patient or in a patient candidate to immunosuppressive drug therapy. These ... 11/09/06 - 20060252107 - Compositions and methods for diagnosing and treating retinal diseases The present invention relates generally to the preparation and use of retinoid N-retinylidene-N-retinyl-ethanolamine (A2E) conjugated to a carrier polypeptide and to the preparation and use of antibodies that bind specifically to A2E. The invention relates to the use of A2E conjugates as immunogens or vaccines and to the use of ... 11/02/06 - 20060246524 - Nanoparticle conjugates Conjugate compositions are disclosed that include a specific-binding moiety covalently coupled to a nanoparticle through a heterobifunctional polyalkyleneglycol linker. In one embodiment, a conjugates is provided that includes a specific-binding moiety and a fluorescent nanoparticle coupled by a heterobifunctional PEG linker. Fluorescent conjugates according to the disclosure can provide exceptionally ... 11/02/06 - 20060246523 - Antibody conjugates Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled ... 11/02/06 - 20060246522 - C-reactive protein immunoassay and method The present invention is directed towards the synthesis and/or use of a mixture of analyte capture reagents comprising antibodies and a non-immunological reagent provided on a solid phase assay, selected to screen for very high and low levels of an analyte. The non-immunological reagent comprising a PC-conjugate that contains multiple ... 10/26/06 - 20060240497 - Assaying apparatus, kit, and method for lipids and associated enzymes Lipid assay method, kit, and apparatus involving exposure of a protein, having a lipid recognition motif that interacts with a target lipid and a competing lipid, to a solution containing the competing lipid, and determining whether the target lipid is present in the solution. The target lipid has a stronger ... 10/26/06 - 20060240496 - Immunogens, derivatives and immunoassay for ethyl glucuronide Ethyl glucuronide (“EtG”) analogs can be prepared for use as immunodiagnostic reagents and in immunodiagnostic protocols. The EtG analogs can be in the form of EtG-based immunogens, and EtG-based antigens. The EtG-based immunogens can be used for preparing anti-EtG antibodies, which can be used in immunoassays. Accordingly, improved immunoassay techniques ... 10/26/06 - 20060240495 - Non-invasive assessment of intra-amniotic environment Assessing fetal health and maturity, and the integrity and health of the amnion, is effected via protein profiling of vaginal fluid, thereby to identify various abnormal conditions during pregnancy. This approach also provides a means for gauging the duration and/or magnitude of intraamniotic/fetal inflammation that occurs during pregnancy. ... 10/12/06 - 20060228763 - Periostin-based diagnostic assays The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia. ... 10/12/06 - 20060228762 - Diagnosis of human glycosylation disorders This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for monitoring the course of treatment of diseases that are associated with glycosylation disorders. ... 10/05/06 - 20060223134 - Doxorubicin immunoassay Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids. ... 10/05/06 - 20060223133 - Monoclonal antibody against connective tissue growth factor and medicinal uses thereof A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics against various mammalian CTGFs useful for detecting and assaying CTGFs present in body ... 10/05/06 - 20060223132 - Phenethanolamine-derived haptens, immunogens, antibodies and conjugates in which, in formula I, Z1 is a crosslinker and Z2 is H and, in formula II, Z1 is H and Z2 is a crosslinker. ... 10/05/06 - 20060223131 - Protein arrays and methods of use thereof The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and ... 10/05/06 - 20060223130 - Detection of post-translationally modified analytes The invention provides methods of analyzing a sample. In general, the methods involve: a) contacting a sample with an array of capture agents; and b) reading the array to detect the presence of a post-translational modification indicator and an analyte-detection moiety. The analytes of the sample may be contacted with ... 09/28/06 - 20060216771 - Method for detecting carcinomas in a solubilized cervical body sample The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a solubilized body sample. The present invention is particularly directed to a method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or ... 09/28/06 - 20060216770 - Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus An IgG1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several tacrolimus metabolites. This antibody is suitable for performance of immunoassays such as homogeneous immunoassays to detect or determine the presence or concentration of tacrolimus in ... 09/28/06 - 20060216769 - Docetaxel immunoassay Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids. ... 09/28/06 - 20060216768 - Dioxetane-nanoparticle assemblies for energy transfer detection systems, methods of making the assemblies, and methods of using the assemblies in bioassays Assemblies comprising nanoparticles and chemiluminescent substrates such as dioxetanes are provided. The assemblies can be used in assays to detect the presence and/or amount of a single analyte or multiple analytes in a sample. Methods of making the assemblies are also described. ... 09/28/06 - 20060216767 - Docetaxel immunoassay Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids. ... 09/28/06 - 20060216766 - Assay for protein isoforms A method for assaying for a protein having at least two isoforms having different glycosylation patterns, the method including contacting a sample containing the protein with a proteolytic enzyme, and detecting the content or relative content of at least one peptide fragment produced by proteolysis of the protein. ... 09/21/06 - 20060211070 - Polyclonal-polyclonal elisa assay for detecting n-terminus-probnp A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure ... 09/21/06 - 20060211069 - Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In ... 09/21/06 - 20060211068 - Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In ... 09/21/06 - 20060211067 - Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In ... 09/21/06 - 20060211066 - Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In ... 09/21/06 - 20060211065 - Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In ... 09/21/06 - 20060211064 - Detection of hypertension using glucuronidated metabolic products A method of assessing arachidonic acid (AA) metabolites-dependent hypertension by measuring glucuronidated dihydroxyeicosatrienoic acids (DHETS) and DHET metabolites in a biological sample which contains the epitopes unique to DHET (using any methods including GC/MS, LC/MS or ELISA). An example of the glucuronidated DHET metabolite is DHET-alcohols such as omega or ... 09/21/06 - 20060211063 - Phosphokinase assay A method of detecting protein kinases in a sample by coating a solid surface with a buffer containing protease and phosphatase inhibitors and immobilizing a labeled antibody to the coated solid surface, whereby protein kinases react with the antibody, thereby detecting a presence of the protein kinases. Also provided is ... 09/14/06 - 20060205025 - Rapid prion-detection assay Assays are provided for rapid detection, with high specificity of the pathogenic form of prion protein responsible for neurodegenerative diseases affecting humans and animals, such as transmissible spongiform encephalopathy in bovine, sheep, and cats. Also provided are assays for testing animal feedstock, such as animal feed, for the presence or ... 09/14/06 - 20060205024 - Method to diagnose and evaluate progression of alzheimer's disease A method or technique of detecting, diagnosing, monitoring, and evaluating a neurodegenerative disease, such as Alzheimer's disease, in a human body fluid is disclosed. The invention provides for a method of detecting amyloid peptides associated with erythrocytes and amyloid peptide complement complexes, as a diagnostic test for the detection, monitoring, ... 09/14/06 - 20060205023 - Sp1 as a marker in diagnosis and prognosis of non-alcoholic steatohepatitis (nash) and target in drug screening for nash Phosphorylated Sp1 can be used as a marker for in vitro diagnosis of non-alcoholic steatohepatitis (NASH) as well as a therapeutical target of said condition. ... 09/14/06 - 20060205022 - Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample. ... 09/07/06 - 20060199237 - Clinical assay for monitoring of agmatine The present invention is directed to a process for determining the level of agmatine in biological samples, especially that of human subjects. In one embodiment, the present invention comprises an assay and a method for quantitatively detecting agmatine in blood serum and other body fluids. ... 09/07/06 - 20060199236 - Immunoassay with extended dynamic range The present invention provides a method of performing a competitive assay for the detection and quantification of an analyte over an extended dynamic range. This is achieved by a multi-step sample addition method whereby different concentrations of sample are added at different times during the assay that produces a dose-response ... 09/07/06 - 20060199235 - Compositions and method for accurate early pregnancy diagnosis The invention provides improved assays for detection of pregnancy. In the assays, pregnancy associated glycoproteins are analyzed in conjunction with progesterone analysis. The techniques of the invention overcome limitations in the prior art by reducing the rate of false positive results. The assays provided by the invention can be implemented ... 08/31/06 - 20060194269 - Polysaccharide structure and sequence determination The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) ... 08/31/06 - 20060194268 - Method for measuring spinorphin The present invention aims at providing a method for measuring spinorphin in a sample collected from a living body accurately with high sensitivity. The present invention provides a method for measuring spinorphin in a sample collected from a living body, comprising the steps of: (A) mixing a sample collected from ... 08/24/06 - 20060188951 - Method for measuring the level of anti-beta-amyloid antibody in body fluids and diagnostic kit for alzheimer's disease using same A method for measuring a concentration of a β-amyloid antibody in a body fluid sample through a reaction forming an antigen-antibody complex uses an antigen protein binding specifically to the β-amyloid antibody existing in a body fluid of an Alzheimer's disease patient. A diagnostic kit for Alzheimer's disease using the ... 08/17/06 - 20060183175 - Diagnosis of preeclampsia The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as ... 08/17/06 - 20060183174 - Diagnosis A method for screening, diagnosis or prognosis of heart failure in a mammalian subject, for determining the stage or severity of heart failure in a mammalian subject, for identifying a mammalian subject at risk of developing heart failure, or for monitoring the effect of therapy administered to a mammalian subject ... 08/17/06 - 20060183173 - Protein achieving improved blocking efficiency It is intended to provide a method of conveniently screening a novel protein or a novel partial sequence protein having a blocking ability based on amino acid sequence data; and a protein achieving an improved blocking efficiency that can be expressed on a large scale in Escherichia coli. A method ... 08/17/06 - 20060183172 - Diagnostic assay for thrombin-activatable fibrinolysis inhibitor (fafi) The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFla or TAFlai), or a derivative or variant thereof, but not the TAFI proenzyme (TAFI) or the N-terminal activation peptide of TAFI. ... 08/10/06 - 20060177884 - 5-fluoro-uracil immunoassay Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids. ... 08/10/06 - 20060177883 - 5-fluoro-uracil immunoassay Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids. ... 08/10/06 - 20060177882 - Immunoassays with enhanced selectivity The present invention provides a method for the detection of an analyte in a specimen comprising two steps. First, the specimen is contacted with a substrate having receptors bound thereon, having higher affinity for cross-reactive substances than for the analyte, in order to increase the ratio of the analyte to ... 08/03/06 - 20060172359 - Method of preparing cow brain homogenate An assay method is disclosed which isolates and detects the presence of a disease related conformation of a protein (e.g., PrPSc) present in a sample also containing the non-disease related conformation of the protein (e.g., PrPSc). The sample is treated (e.g., contacted with protease) in a manner which hydrolyzes the ... 08/03/06 - 20060172358 - Novel chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays. ... 08/03/06 - 20060172357 - Detecting human antibodies in non-human serum The present invention provides for the quantification of a human, human-chimeric, humanized antibody, or a fragment thereof, without the necessity of using a target-specific molecule. More particularly, the invention relates to a quantification assay that includes the step of blocking non-specific binding sites of a capture reagent with a blocking ... 08/03/06 - 20060172356 - Immunoassays for lamotrigine Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, ... 07/27/06 - 20060166297 - High affinity anti-n¹,n¹²-diacetylspermine monoclonal antibody The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is ... 07/27/06 - 20060166296 - Standard compound for immunoassay for dioxin and method of immunoassay for dioxin wherein R1, R2, R3 and R4 may be the same or different and represent chlorine or hydrogen, n is an integer from 1 to 10, and Z represents an amino acid residue or peptide. ... 07/27/06 - 20060166295 - Method for determination of likelihood of occurrence of preterm labor in pregnant females The presence of 3-chlorotyrosine in vaginal secretions in a predictor of the likelihood preterm premature rupture of the fetal membranes, i.e., the chorioamnion and/or the occurrence of the risk of preterm labor. 3-chlorotyrosine is a marker for the excessive production of hypochlorous acid which causes focal areas of increased collagen ... 07/20/06 - 20060160162 - Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner ... 07/20/06 - 20060160161 - Methods for assessing antibodies to neurodegenerative disease-associated antigens The invention provides methods for assessing immunoglobulins directed to neurodegenerative disease-associated antigens. Methods of the instant invention involve specific, sensitive and precise identification of Ig classes of antibodies present in a test sample that are capable of binding an immobilized neurodegenerative disease-associated antigen. The enhanced assessment of antibodies directed to ... 07/20/06 - 20060160160 - Detection of human antibodies to squalene in serum The invention is a method and assay for detecting human squalene antibodies in sera or plasma using a blocking agent of −0.5% casein in a phosphate buffered saline (PBS) solution. ... 07/13/06 - 20060154321 - Polyclonal-monoclonal elisa assay for detecting n-terminus probnp A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure ... 07/13/06 - 20060154320 - Enzyme activity measurement using bio-layer interferometry Disclosed are enzyme assays using biolayer interferometry. Assays may be carried out using immobilized substrate or with a substrate capture format. In certain embodiments, the assays are carried out using unlabeled substrates. The methods are broadly applicable to enzyme assay measurements, can be carried out in vivo or in vitro, ... 07/13/06 - 20060154319 - Inhibition of bradykinin release The invention is related to a method for treating or preventing a disorder resulting from the release of bradykinin in said mammal, particularly a mammal which produces a HBP which binds to a HBP antagonist, e.g. a monoclonal antibody that binds to at least one epitope of human HBP, comprising ... 07/13/06 - 20060154318 - Stable isotope labeled polypeptide standards for protein quantitation This invention relates to proteins having an amino acid sequence containing several amino acid subsequences found in nature and wherein at least two different subsequences act as monitor sequences, said subsequences being part of at least one natural protein which is a target protein, wherein the end of each of ... 07/13/06 - 20060154317 - Method of immunoassaying taritrate resistant acid phosphatase 5b and kit to be used therein Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b bonded to the antibody to enzyme reaction with a 2-halo-4-nitrophenylphosphoric acid or a salt thereof, a substrate ... 07/13/06 - 20060154316 - Elisa method for the detection of guanylate binding protein 1 (gbp-1) A method for the identification and/or quantification of GBP-1 or fragments of this protein in the culture supernatant of a tissue sample, a body fluid sample or a sample from a cell culture supernatant is described. ... 07/06/06 - 20060148018 - Insulin-like growth factor binding protein-4 protease Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A), are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents also are described. ... 07/06/06 - 20060148017 - Compositions and methods for monitoring enzyme activity The invention provides a method to monitor the activity of an enzyme comprising the step of monitoring the addition to at least one polypeptide of a phosphate moiety. The polypeptide is an isolated polypeptide, or a fragment thereof, comprising a non-natural site sufficient for the addition of a phosphate (PO4). ... 07/06/06 - 20060148016 - Nanoparticle for bioaffinity assays Thus this invention relates to a nanoparticle, useful for bioaffinity assays. The nanoparticle has a self-assembling shell built up of several protein and/or peptide subunits, which protein and/or peptide subunits can be of one or several different types, assembled in an organized manner to form the shell having an inner ... 06/29/06 - 20060141548 - Immunoassays for everolimus Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided. ... 06/29/06 - 20060141547 - Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis The present invention relates to a novel diagnostic marker useful for the diagnosis of rheumatoid arthritis comprising the autoantibodies of mannose binding lectin protein and a process thereof. ... 06/22/06 - 20060134713 - Biosensor apparatus and methods of use Disclosed herein are methods and devices for detecting the presence of an analyte of interest. A biosensor device can include a reaction chamber and an electrochemical detection chamber. The reaction chamber can include at least one immobilized binding site and a probe conjugate adapted to bind to at least one ... 06/22/06 - 20060134712 - Multiplexed assay methods The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods. ... 06/22/06 - 20060134711 - Methamphetamine derivatives and conjugates for immunoassay wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms, R2 is a leaving group, and R3 is a protecting group. ... 06/22/06 - 20060134710 - Wdr11 protein assay An affinity-based analyte separation method of assaying a sample for a WDR11 protein. The method can be coupled to a variety of detection methods, including detection of an observable label or detection using mass spectrometry. The methods may be applied to assessing cancerous cells. ... 06/15/06 - 20060127963 - Microarray-based analysis of rheumatoid arthritis markers A microarray and method of screening for rheumatoid arthritis (RA) in a mammal is disclosed. The method comprises contacting a sample from the mammal to an immobilized polypeptide or fragment thereof homologous to at least a portion of an RA marker protein, and detecting binding of an antibody from the ... 06/15/06 - 20060127962 - Biomarkers for intro-amniotic inflammation Biomarkers have been discovered that are capable of identifying intra-amniotic inflammation. A single biomarker or combination of biomarkers can be used to qualify the risk of preterm delivery in a patient, provided that at least one of the biomarkers is a calgranulin, preferably calgranulin A or C. The result is ... 06/08/06 - 20060121545 - Rapamycin conjugates and antibodies Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody. ... 06/08/06 - 20060121544 - Molecular modification assays Systems for detecting molecular modifications and the presence and/or activity of enzymes and/or other agents involved in facilitating or otherwise regulating such modifications. ... 06/08/06 - 20060121543 - Chemical arrays and methods of using the same Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. The resultant composition of solution phase ... 06/01/06 - 20060115865 - Lamotrigine analogs Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, ... 06/01/06 - 20060115864 - Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents. ... 06/01/06 - 20060115863 - Inositol phosphate detection assays Assays for detecting or measuring inositol phosphate, for detecting or measuring signaling pathways, for detecting or measuring the activity of phospholipase C-linked receptors and/or their cognate pathways, for detecting or measuring the activity of inositol kinases and inositol phosphatases, and for screening for compounds that modulate the activity of signaling ... 05/25/06 - 20060110780 - Plasma c5a levels as an indicator of asthma severity This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient by determining the levels of C5a or C5a-desArg in the patient's blood, plasma or serum. ... 05/18/06 - 20060105410 - Sulfonate compound and fluorescent probe using the same In the formula (I), an atomic group A-O is an atomic group that forms a fluorescent compound upon cleavage of a covalent bond with a sulfonyl group. There may be one or plural atomic groups B—SO3— bound to an atomic group A. B is a ring substituted by one or ... 05/18/06 - 20060105409 - Ubiquitin ligase assay The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes. ... 05/18/06 - 20060105408 - Myeloperoxidase, a risk indicator for cardiovascular disease Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level ... 05/18/06 - 20060105407 - Protein chip for analyzing interaction between protein and substrate peptide thereof A protein chip of a S—L—SP form wherein a substrate peptide (SP) is immobilized on a solid substrate (S) by the mediation of a linker protein (L). Such chip is usefully employed in a method for analyzing the interaction between a reactive protein and its substrate peptide involving the steps ... 05/11/06 - 20060099665 - Taxol immunoassay Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids. ... 05/11/06 - 20060099664 - Simultaneous screening of multiple analytes Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner for each ... 05/11/06 - 20060099663 - Peptide sequence tags and method of using same Peptide sequence tags are identified and used to produce a class of global antibodies, which recognize all members of RbcL protein family with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to the major RbcL protein of the RUBISCO enzyme catalyzing of carbon ... 05/11/06 - 20060099662 - Assay for antibodies The presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample can serve as an important clinical or other analytical or diagnostic tool. ELISA methods, and kits for such assays, as well as anti-idiotypic antibodies and hybridomas producing them, are developed to detect levels ... 05/04/06 - 20060094073 - Saliva immunoassay for detection of antibodies for cardiovascular disease A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin, oxidized LDL, β-2-glycoprotein, heat shock protein-60, platelet glycoprotein, and immune complexes. It then compares the results to normal levels to determine the likelihood ... 05/04/06 - 20060094072 - Peptide sequence tags and method of using same The presence of a member of a protein in a nitrogenase enzyme system is detected by obtaining a sequence tag selected form the group consisting of VESGGPEPGVGC, VSQSLGHHIAND, CTTCMAEVIGDDL and CMAEVIGDDL, utilizing the tag to elicit the production of antibodies, and using the antibodies to measure the concentration of the ... 05/04/06 - 20060094071 - Method for enriching and tracking pathologic modified prions-proteins(prpsc) The invention relates to a method for enriching and tracking pathologic modified prions-proteins (PrPsc) of living organisms. ... 04/27/06 - 20060088897 - Modulators Disclosed is an isoform-specific antagonist of PAK kinase, which is preferably a molecule capable of modulating an interaction between Nck and a PAK isoform. In particular, αPAK, βPAK and γPAK specific inhibitors are disclosed. Also included are methods of treating diseases, preferably characterised by a defect in nerve regeneration, comprising ... 04/27/06 - 20060088896 - Diagnostic device for rapid determination of buprenorphine This invention relates to a method of detecting buprenorphine in biological fluids (especially urine), and to a device and kit which use chromatographically mobile reagents labelled with gold clusters. The method involves contacting urine sequentially with anti-buprenorphine antibodies labelled with gold clusters and with buprenorphine immobilised on a porous support, ... 04/13/06 - 20060078957 - Novel aggrecanase A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating ... 04/13/06 - 20060078956 - Methods to identify compounds that modulate rage Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed ... 04/13/06 - 20060078955 - Method for retrieving delta9-thc from oral fluid The present invention discloses methods and kits for retrieving a cannabinoid from an oral fluid collection device having adsorbed the cannabinoid and to prepare an oral fluid specimen for the determination of Δ9-tetrahydrocaninabinol (Δ9-THC) concentration qualitatively or quantitatively by an enzyme immunoassay. The methods and kits are particularly useful in ... 04/13/06 - 20060078954 - Device and method to simultaneously detect different antibodies and antigens in clinical alimentary and environmental samples Method and device to simultaneously detect different antibodies and antigens via immunoenzimatic tests and ELISA (Enzyme Linked ImmunoSorbent Assay) constituted by small absorbent cylinders, on which the immunocomplexes are formed, blocked at a modular distance on a probe; that carries a label to identify the sample under examination. ... 04/13/06 - 20060078953 - Epad, an oocyte specific protein The present invention is directed to a human egg specific protein (ePAD), antibodies specific for the human egg specific protein and the use of the ePAD protein to identify antagonists of ePAD activity. Antagonists of ePAD activity are anticipated to have utility as female contraceptive agents. ... 04/06/06 - 20060073536 - Immunoassays for determining vitamin b12, and reagents and kits therefor Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the absence of vitamin B12, and that are released from binding ... 04/06/06 - 20060073535 - Methods and kits for measuring adamts13/fxi complexes Provided are assays and kits to detect ADAMTS13 activity using peptide substrates and ADAMTS13/Factor XI complexes using ELISA. These assays and kits can be used for diagnostic applications and to evaluate treatment of thrombotic thrombocytopenic purpura (TTP). Also provided is a novel form of ADAMTS13 found on platelets. ... 04/06/06 - 20060073534 - Method for cleaving and deglycosylating antibodies to promote ligand binding The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to ... 04/06/06 - 20060073533 - Production of ugppase What are disclosed are a purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its production by means of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination ... 03/23/06 - 20060063216 - Method for diagnosing a predisposition of psychosis in a progeny This invention relates to methods for diagnosing a predisposition to psychosis in a progeny who possesses Cw antigen, comprising, obtaining a biological sample from the mother of the progeny; determining the presence of anti Cw antibody in the biological sample, where the presence of an anti Cw antibody in the ... 03/16/06 - 20060057656 - Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids. ... 03/16/06 - 20060057655 - Method for the detection of irradiation treatment of foods An object of the present invention is to provide a novel method for detecting irradiation treatment of foods. The present invention provides a method for detecting irradiation treatment of foods comprising the steps of (A) obtaining a fraction containing one or more irradiation-generated fragments of natural high-molecular weight compound(s) from ... 03/09/06 - 20060051824 - Tetrahydrocannabinoid antigens and method of use The present invention is directed to Δ8-THC and Δ9-THC compounds useful for the covalent attachment to immunogenic molecules to form antigens for the preparation of specific binding molecules to Δ9-Tetrahydrocannabinol, Δ9-Tetrahydrocannabinoids, Δ8-Tetrahydrocannabinol, and Δ8-Tetrahydrocannabinoids, and their derivatives and metabolites. The present invention is directed to the compounds, their method of ... 02/16/06 - 20060035296 - Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to ... 02/16/06 - 20060035295 - Method for determination of thymidine kinase 1 activity and the use thereof The present invention concerns a new method that enables safe, rapid, accurate and specific determination of thymidine kinase 1 activity in human or animal body fluids and tissue/cell extracts for routine analysis of samples with low levels of activity by using AZT or 3′ derivatives of thymidine as substrate and ... 02/02/06 - 20060024770 - Immunoassay element The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and ... 02/02/06 - 20060024769 - Taxol immunoassay Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids. ... 02/02/06 - 20060024768 - Taxol immunoassay Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids. ... 02/02/06 - 20060024767 - Rapid prion-detection assay Assays are provided for rapid detection, with high specificity of the pathogenic form of prion protein responsible for neurodegenerative diseases affecting humans and animals, such as transmissible spongiform encephalopathy in bovine, sheep, and cats. Also provided are assays for testing animal feedstock, such as animal feed, for the presence or ... 01/26/06 - 20060019325 - Screening assay Screening assays for identifying an agent that modulates the activity of a phosphate catalyzing enzyme. ... 01/05/06 - 20060003396 - Screening arrangement for screening immunoassay tests and agglutination tests Immunoassay tests or agglutination tests run on samples of bodily fluid to detect the presence of particular compounds such as drugs in the body may be screened in the screening device. A test membrane is inserted into the screening device and illuminated. The reflected image is detected and the digitised ... 01/05/06 - 20060003395 - Measurement method using biosensor It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance immobilized on a biosensor and the analysis of the effects of the above substance on the biological activity of the physiologically ... 01/05/06 - 20060003394 - Enzymatic detection techniques A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter ... 12/29/05 - 20050287618 - Labeling immobilized proteins with dipyrrometheneboron difluoride dyes The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers. ... 12/29/05 - 20050287617 - Inhibitors of macrophage migration inhibitory factor and methods for identifying the same including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same. ... 12/29/05 - 20050287616 - Method of assaying denaturation of proteins The present invention encompasses a method for performing an antibody-antigen assay using an ion-exchange technique prior to performing an antibody-antigen assay. Actives from protein-denaturing solutions are physically removed from the test sample, preferably by using an ion-exchange resin. The present invention also includes a method of performing an antibody-antigen assay, ... 12/29/05 - 20050287615 - Screening assay to identify inhibitors of the murd enzyme using an activator-independent murd enzyme A method of identifying inhibitors of an activator-independent MurD enzyme comprising contacting the enzyme with a test compound in the presence of enzyme substrates and appropriate buffers and detecting any modulation of enzyme activity by the test compound. ... 12/29/05 - 20050287614 - Assay for detecting an analyte containing or labelled with a haem moiety A method for detecting an analyte containing or labelled with a haem moiety within a sample, said method comprising: a) contacting said sample with a magnetic bead having immobilised thereon a specific binding partner for said analyte and allowing analyte to bind to said specific binding partner; b) separating the ... 12/29/05 - 20050287613 - Polyclonal-polyclonal elisa assay for detecting n-terminus-probnp A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure ... 12/22/05 - 20050282237 - Immunological analysis carrier and an immunological analysis method using the same The present invention provides an immunological analysis carrier comprising at least one of an antibody against a target substance, an agent capable of specifically binding a target substance, a part of an antibody against a target substance and a part of an agent capable of specifically binding a target substance, ... 12/08/05 - 20050272109 - Method for immobilizing conjugates in diagnostic tests The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a control zone. The present invention additionally provides new conjugates and reagent kits. ... 12/08/05 - 20050272108 - Stabilized two component system for chemiluminescent assay in immunodiagnostics The present invention provides stabilized chemiluminescent formulations for use in in vitro diagnostics, including competitive as well as sandwich-type immunological assays. The stabilized assay system may be composed of two components, where the first component may contain a chemiluminescent organic compound, an enhancer, a homogenizing agent, and a suitable buffer ... 12/08/05 - 20050272107 - Intracellular antibodies The invention related to intracellular single domain immunoglobulins, and to a method for determining the ability of an immunoglobulin single domain to bind to a target in an intracellular environment, comprising the steps of: a) providing a first molecule and a second molecule, wherein stable interaction of the first and ... 11/17/05 - 20050255533 - Comprehensive food allergy test The present invention relates to methods and devices for detecting biological entities and components associated with hypersensitivity reactions in patients with food allergies. Specifically, the assays of the invention are capable of qualitatively and/or quantitatively measuring IgG, IgA, IgM and/or IgE antibodies and immunocomplexed C3b (IC-C3b) produced as a result ... 11/03/05 - 20050244905 - Nitrated fibrinogen as a marker for coronary artery disease and rapid blood clot formation Methods and assays are disclosed for predicting a patient's risk for coronary artery disease. The methods comprise obtaining a biological sample from a patient and determining the amount of nitrated fibrinogen which is linked with coronary artery disease. Detection of nitrated fibrinogen is indicative of susceptibility to develop coronary artery ... 11/03/05 - 20050244904 - Diagnostics based on signal peptide detection The invention provides methods and a kit for detecting peptides and proteins, which may be indicative of heart disease by detecting signal peptide levels for a protein in a subject's bodily fluid. ... 11/03/05 - 20050244903 - Diagnostic and examination method for eating disorder The present invention provides a diagnostic agent for eating disorders comprising as an active ingredient an antibody against brain-derived neurotrophic factor, and a method for detecting eating disorders comprising measuring of the concentration of a brain-derived neurotrophic factor in blood. Particularly, the eating disorders can easily be diagnosed by measuring ... 11/03/05 - 20050244902 - Methods for determining levels of human b-type natriuretic peptide precursors The present invention provides an alternate and more accurate assay for measuring the levels of BNP precursors, or fragments thereof, in a sample by determining the concentration of BNP precursors, or fragments thereof, in a sample obtained from a mammal, the method comprising treating the sample with an agent that ... 10/27/05 - 20050239149 - Chemiluminescence enhancer The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a ... 10/20/05 - 20050233400 - Proteomic method for predicting success of rescue cerclage Through determination of the presence or absence of proteomic biomarkers within an amniotic environment, the present invention provides for the identification of the condition(s) within the amniotic environment and allows for predictive indication of the success of a pregnancy under the condition(s) and courses of treatment for the condition(s). The ... 10/20/05 - 20050233399 - Rapid quantitative analysis of proteins or protein function in complex mixtures Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The methods employ affinity labeled protein reactive reagents having three portions: an affinity label (A) covalently linked to a protein reactive group (PRG) through a linker ... 10/20/05 - 20050233398 - Lidocaine analogs and methods of making and using same R6 and R7 are each independently H or C1 to C20 alkyls; and including salts thereof. The analogs are immobilized on latex particles and prepared for use in assays for lidocaine. ... 10/20/05 - 20050233397 - Molecular-specific urokinase antibodies Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three-dimensional configuration of the molecule and are uniquely homologous to urokinase. Antibodies are directed against the ... 10/20/05 - 20050233396 - Screening method for orthopoxvirus antivirals The focus of the present invention is an effective anti-poxvirus drug for use in treating or preventing human disease caused by pathogenic poxviruses. More particularly, the present invention relates to antiviral drugs that target the poxvirus proteinase responsible for core protein maturation, a step which is absolutely essential for the ... 10/06/05 - 20050221406 - Method, composition and device for treating starch related diseases The present invention includes a method of diagnosing an insulin resistant mammal including the steps of obtaining one or more samples for testing; and determining the level of starch in the one or more samples, whereby the presence of starch correlates with insulin resistant. ... 10/06/05 - 20050221405 - Immunoassays for buprenorphine and norbuprenorphine Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) or norbuprenorphine (norBUP) and (ii) an antibody raised against an immunogen of buprenorphine (BUP) ... 10/06/05 - 20050221404 - Binding of pathological forms of prion proteins Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine ... 09/29/05 - 20050214882 - Reagents, methods and kits for the universal rapid immuno-detection This invention relates to a novel immuno-detection methods, kits and reagents. The Combination of this invention, combining at least two of the following reagents of a Non-specific Competitor, a Specific Indicator, a primary antibody and an antigen, provides a faster and easier method for an immuno-detection, combining at least two ... 09/29/05 - 20050214881 - Device for analyte measurement A biochemical analysis instrument for multiple fluid analyses includes a housing. A sensor for sensing a reaction is disposed in the housing. An aperture is formed in the housing. A test tape housing area is formed in the housing, and the sensor is disposed to selectively move within the housing ... 09/22/05 - 20050208607 - Immunoassays for everolimus Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided. ... 09/22/05 - 20050208606 - Apparatus for and method of detecting the presence of an airborne mycotoxin in an enclosure An apparatus for detecting the presence of an airborne mycotoxin in an enclosure. Pumping apparatus draws a portion of environmental air from the enclosure. A medium receives the portion of the environmental air and separates mycotoxins from the portion of air. Testing apparatus determines the presence of mycotoxins separated from ... 09/22/05 - 20050208605 - Secreted factors The invention concerns new secreted factors encoded by clones P00184-D11 (SEQ ID NO: 1), P00185_D11 (SEQ ID NO: 3), P00188_D12 (SEQ ID NO: 5), P00188_E01 (SEQ ID NO: 7), P00194_G01 (SEQ ID NO: 9), P00194_G05 (SEQ ID NO: 11), P00194_H10 (SEQ ID NO: 13), P00199_D08 (SEQ ID NO: 15), P00203_D04 ... 09/22/05 - 20050208604 - Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. The distance of the amphetamine moiety and the methamphetamine moiety from ... 09/22/05 - 20050208603 - Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/or for a methamphetamine for use in assays for the determination ... 09/22/05 - 20050208602 - 89 human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, ... 09/08/05 - 20050196817 - Biomarkers for sepsis Biomarkers for sepsis and resulting mortality can be detected by assaying blood samples. Changes in the concentration of the biomarkers can be used to indicate sepsis, risk of sepsis, progression of sepsis, remission from sepsis, and risk of mortality. Changes can be evaluated relative to data sets, natural or synthetic ... 09/08/05 - 20050196816 - Immunoglobulin e detection in mammalian species The present invention provides antibodies (e.g., monoclonal antibodies) that specifically binds to mammalian IgE (e.g., dog IgE). In some embodiments the antibodies bind to an epitope between amino acids 145-166 of mammalian IgE; in other embodiments the antibodies bind to an epitope between amino acids 356-374 of mammalian IgE. The ... 08/25/05 - 20050186646 - Rapid assay to detect adamts-13 activity The present invention is directed to an assay for ADAMTS-13 activity. The assay provides rapid analysis of ADAMTS-13 activity in a biological sample under non-denaturing conditions. Furthermore, the present invention is directed to a recombinant polypeptide with a functional ADAMTS-13 site that is useful in ADAMTS-13 activity assays. ... 08/25/05 - 20050186645 - Method for analyzing a glycomolecule The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides. ... 08/18/05 - 20050181466 - Immunosorbent blood tests for assessing paroxysmal cerebral discharges Immunosorbents, kits and compositions for diagnosing a central nervous system disorder, particularly paroxysmal cerebral discharges and epilepsy, comprising measuring the concentration of GluR1 or fragment thereof and/or GluR1 antibodies in a biological sample from a human subject. The method is particularly useful for identifying individuals that are at risk for ... 08/11/05 - 20050176080 - Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays The invention teaches derivatives of ascomycin and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of tacrolimus in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to tacrolimus with cross-reactivity of no more than 5% with each of 15-O-demethyl tacrolimus, 31-O-demethyl ... 08/11/05 - 20050176079 - Polypeptide bioconjugates, methods of making the bioconjugates and assays employing the bioconjugates A method for detecting the presence or amount of an analyte in a sample is described. The method involves contacting the surface of the solid support with the sample and detecting analyte on the surface of the solid support. A bioconjugate comprising a polypeptide conjugated to a polysaccharide is deposited ... 08/11/05 - 20050176078 - Detection and/or monitoring of synuclein-related diseases The invention provides a method of diagnosing a synucleinopathy in a patient and also a method monitoring the effectiveness of a therapeutic agent that has been administered to a patient for the purpose of treating a synucleinopathy. The method comprises analysing a non-cerebral body fluid sample taken from the patient ... 08/04/05 - 20050170445 - Methods of establishing profiles for use in evaluating wound healing and biocompatibility of implant materials and microarrays useful therefor Protein detection microarrays are used to specifically detect cytokines and growth factors that are associated with wound healing and with host organism responses to foreign, implanted materials (i.e., biocompatibility). Methods of establishing profiles that can be used in evaluating wound healing and biocompatibility take advantage of such cytokine- and growth ... 08/04/05 - 20050170444 - Methods of diagnosing and treating pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia by detecting the levels of placental growth factor in a subject. ... 08/04/05 - 20050170443 - Methods and use of binding components for improving assay specificity The present invention relates to detecting an analyte of interest in the presence of other analytes that may be of interest or moieties that interfere with normal assay protocols. ... 08/04/05 - 20050170442 - Bimolecular optical probes Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase ... 07/28/05 - 20050164320 - Fluid based analysis of multiple analytes by a sensor array A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment ... 07/28/05 - 20050164319 - Aggrecanase-1 and -2 peptide substrates and methods The present invention describes synthetic peptide substrates of the metalloproteases, agggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases. ... 07/28/05 - 20050164318 - Methods of diagnosing muscle damage A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. The method can also ... 07/28/05 - 20050164317 - Novel methods for the assay of troponin i and t and complexes of troponin i and t and selection of antibodies for use in immunoassays Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ... 07/28/05 - 20050164316 - Biophotonic sensors and methods of use thereof The present invention provides novel biophotonic sensors that have molecular recognition with high sensitivity for target molecules. In one embodiment, the biophotonic sensors have capture moieties with high specificity for molecules of interest (target molecules) and biophotonic conjugates. The biophotonic conjugates exhibit a characteristic photonic activity only when a target ... 07/21/05 - 20050158811 - Human protein acyl transferases and methods of uses therefor The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefor. In addition, methods of screening for modulators of human Ras palmitoyl acyl transfersase, including high throughput yeast screens, are also provided. ... 07/14/05 - 20050153381 - Immunocapture of mitochondrial protein complexes Provided herein is a library of monoclonal antibodies specific for native proteins and native protein complexes of the oxidative phosphorylation (OXPHOS) system (for example, Complex I, II, III, IV, or V, or any protein subunit of any of such complexes). Hybridomas expressing such antibodies and antibodies that competitively inhibit the ... 07/14/05 - 20050153380 - Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells) thereof, and products derived from plants, animals or microorganisms. ... 07/14/05 - 20050153379 - Method and apparatus for in vivo collection of circulating biological components The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of ... 07/14/05 - 20050153378 - Anti-dioxins monoclonal antibody suitable for assaying dioxins in environment and hybridoma producing the same The object of present invention is to provide an immunoassay for dioxins which can rapidly and simply afford measured values having a good correlation with analytical values of dioxins by the official method (GC/MS method). The above object is achieved by using the monoclonal antibody of the present invention having ... 07/14/05 - 20050153377 - Method for determining crp using phosphorylcholine The present invention provides a method for determining the concentration of C-reactive protein in a sample using labeled phosphorylcholine. ... 07/07/05 - 20050148040 - Screening for gestational disorders The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy. ... 06/30/05 - 20050142626 - Diagnostic methods for asthma Screening methods for asthma and analogous diseases in which activated eosinophils are found at the disease site are provided. The methods involle assaying for the presence of brominated tyrosine species in a bodily sample which has been obtained from a test subject. The brominated tyrosine species are either free in ... 06/30/05 - 20050142625 - Antibodies against pak5 The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of ... 06/30/05 - 20050142624 - Chip and method for analyzing enzyme immunity An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in ... 06/30/05 - 20050142623 - Sensor protein and use thereof The object of the present invention is to utilize, as a sensor protein, a molecular recognizing ability of a protein that scarcely undergoes any structural change by the binding of a target substance. According to the present invention, there is provided a sensor protein comprising an insert-type fusion protein composed ... 06/23/05 - 20050136498 - Marker for inflammatory conditions Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is desc |