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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay > Involving Avidin-biotin Binding Involving Avidin-biotin BindingInvolving Avidin-biotin Binding patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/05/07 - 20070077603 - Elisa to detect multimeric forms of a protein The present invention provides methods of detecting multimeric forms of protein S, or other proteins in plasma, complex mixtures, and tissue samples. The invention further provides methods of diagnosing a subject as having or as being at risk for having a multimeric protein-associated disease. The invention further provides methods of ... 03/08/07 - 20070054326 - Antibody-based protein array system The invention of novel protein microarrays and protein microarray-based techniques to determine the presence and amounts of proteins of interest are described. These microarrays and methods of use can be used for the simultaneous detection of a multiplicity of antigens or antibodies in a high throughput assay based upon the ... 03/01/07 - 20070048807 - Diagnostic test kits with improved detection accuracy A diagnostic test kit that provides an integrated system for accurately detecting a test analyte over a broad range of possible concentrations is provided. One feature of the integrated system is that it is capable of indicating whether an analyte is within the “hook effect” region. Based on this indication, ... 02/22/07 - 20070042442 - Protein microarrays on mirrored surfaces for performing proteomic analyses Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large arrays of proteins that may be useful for studying protein-protein interactions to improve understanding ... 02/22/07 - 20070042441 - Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for ... 02/22/07 - 20070042440 - Biosensor for analyzing quantitatively analyte with a predetermined size and larger than, and manufacturing method thereof The present invention discloses a biosensor for quantitatively analyzing a bio-material and a manufacturing method thereof. The biosensor has an exposed conductive region of a few-nanometer scale distributed on an insulated metallic substrate in a desired pattern or randomly. The quantitative analysis of protein can be carried out by means ... 02/22/07 - 20070042439 - Porphyrin compound containing biotinyl group and use thereof wherein Por represents a porphyrin residue optionally forming a metal complex; Bi represents an optionally substituted biotinyl group; and A represents a C1-C20 hydrocarbyl group, or a heterohydrocarbyl group having 1-5 heteroatoms selected from a group consisting of oxygen, sulfur, and nitrogen, and having 1-20 atoms in total; a method ... 02/22/07 - 20070042438 - Scd4ol and placental growth factor (plgf) used as a biochemical marker combination in cardiovascular diseases The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment ... 02/15/07 - 20070037223 - Isotope labeling methods The present invention relates to a method for the analysis of differential expression of proteins employing a radioactive label, characterized by cleaving a tag from peptides labeled with a cICAT reagent, separating and purifying the resultant labeled peptides, and performing an analysis in mass spectrometry. ... 02/01/07 - 20070026466 - Methods for predicting pregnancy outcome in a subject by hcg assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin ... 01/25/07 - 20070020701 - Magnetic resonance system and method to detect and confirm analytes A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the ... 01/25/07 - 20070020700 - Lateral flow assay and device using magnetic particles A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a ... 01/25/07 - 20070020699 - Lateral flow assay and device using magnetic particles A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a ... 01/18/07 - 20070015222 - Isotope labeling methods The present invention relates to a method for the analysis of differential expression of proteins employing a radioactive label, characterized by cleaving a tag from peptides labeled with a cICAT reagent, separating and purifying the resultant labeled peptides, and performing an analysis in mass spectrometry. ... 12/28/06 - 20060292641 - Immunoassay method The present invention provides an immunoassay method easier in operation and smaller in fluctuation of reaction. The immunoassay method according to the present invention is an immunoassay method, which employs a sandwich method using a microchip having an antibody immobilized in the micro-flow channel thereof, comprising feeding a fluid mixed ... 12/07/06 - 20060275842 - Methods and kits useful for the simplification of complex peptide mixtures Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The methods entail the use of tagging moieties that include an amino-acid-specific reactive group (R). The tagging moieties “tag” peptides or proteins at specific amino acids (e.g., by reacting with an ... 12/07/06 - 20060275841 - Assay method and apparatus with reduced sample matrix effects The invention provides methods, kits, and apparatus for increasing the sensitivity of immunoassays performed on environmental samples by reducing sample matrix effects. ... 11/23/06 - 20060263832 - Patterning of centrosomes and centrosome fragments as templates for directed growth of microtubules The present invention relates to a new process to direct the growth and direction of polymerization of microtubules using patterned centrosomes or centrosome fragments on a surface. Incorporation a flow force to direct the position and the growth of microtubules, results in a regular network of microtubules. The invention therefore ... 11/16/06 - 20060257945 - Methods and apparatus for detecting cardiac injury markers using an acoustic device Methods for detecting cardiac injury by detecting one or more cardiac markers are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for a cardiac marker, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes ... 11/02/06 - 20060246519 - Monomeric streptavidin muteins The invention includes a streptavidin mutein having at least one mutation chosen to cause one or more of steric hindrance, charge repulsion, or improvement of solubility by changing interfacial hydrophobic residues to less hydrophobic or hydrophilic residues. The mutein may exist in monomeric form even in the presence of biotin, ... 11/02/06 - 20060246518 - Compositions and methods for detection of sirolimus Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at position 26 or at position 32. Such sirolimus compounds comprising an immunogenic carrier can be employed to raise both polyclonal and monoclonal ... 10/26/06 - 20060240489 - Carbodithioate ligands for nanotechnology and biosensing applications The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces. ... 10/26/06 - 20060240488 - Detection of an immune response to gdf-8 modulating agents This disclosure provides methods for the detection of antibodies to a GDF-8 modulating agent such as, e.g., MYO-029, in a biological sample. Methods to detect an immune response to a GDF-8 modulating agent are also included. In particular, methods to assess an immune response in animals, including humans, to a ... 10/26/06 - 20060240487 - Detection of gdf-8 modulating agents Methods to detect GDF-8 modulating agents in animals, including humans, are provided herein, including methods to detect the presence of exogenous GDF-8 modulating agent such as a GDF-8 inhibitor in a biological sample. In particular, methods to assess the presence and/or quantity of a GDF-8 modulating agent in a biological ... 10/19/06 - 20060234314 - Selective binding and analysis of macromolecules There is disclosed a method for selectively binding micromolecules having a lysine functionality comprising the steps of: providing a sample containing one or more species of macromolecules, each having a lysine functionality; providing a binding reagent having the formula X—NH—C(═NH)—OR or X—L—NH—C(═NH)—OR where X is an affinity label that selectively ... 10/05/06 - 20060223126 - Magnetic particles having porous surfaces, method of producing the same, carrier for biochemical use, and biotin-bonding particles Magnetic particles having porous surfaces are obtained by forming a polymer part (B) soluble in an organic solvent (S) and a polymer part (C) insoluble in the organic solvent (S) on surfaces of magnetic matrix particles (A) and causing the polymer part (B) to come into contact with the organic ... 10/05/06 - 20060223125 - Methods and kits for staining cell membranes Methods and kits are provided for staining cell membranes using a biotinylated phospholipid in conjunction with streptavidin-coated quantum dots. ... 09/28/06 - 20060216760 - Methods for proteomic profiling using non-natural amino acids The invention provides methods, reagents and systems for incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to enrich the proteins or fragments ... 09/28/06 - 20060216759 - Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals ... 09/21/06 - 20060211055 - Capture and release assay system and method A method for detecting one or more components of interest in a fluid-borne sample in a microchannel of a microfluidic device includes flowing the fluid-borne sample, in which the one or more components of interest are bound to a first labeled component binding moiety to form a first labeled complex, ... 09/21/06 - 20060211054 - Method for determining effective parathormone activity in a sample Method for determining the active parathyroid hormone content in a sample, wherein the component of parathyroid hormone polypeptide chains which are oxidized at one or more sites near the PTH receptor binding structure having the amino acids 15 to 22 are specifically excluded from the content determination. Oxidation of the ... 08/31/06 - 20060194262 - P27 ubiquitination assay and methods of use This invention relates to easy and reliable assays for the ubiquitination of p27. Because the assay can be performed as a plate capture assay, or as a homogenous time-resolved fluorescence resonance energy transfer assay, with defined, easily replicatable reaction conditions, it is particularly useful for high-throughput screening of, for example, ... 08/24/06 - 20060188947 - Reagent for producing a protein chip An object of the present invention is to provide a reagent for protein synthesis by a simple operation which is advantageous in a cell-free protein synthesis in many samples in a test using an aimed (specific) protein or a high throughput analysis using a protein chip, etc. and also to ... 08/10/06 - 20060177879 - Magnetic nanoparticles and method of fabrication A method for making a composition of magnetic nanoparticles. The method includes the step of forming the magnetic nanoparticles, each within a protein template, wherein a liquid composition of said protein templates or subunits thereof is subjected to a microporous membrane filtration step prior to formation of said magnetic nanoparticles. ... 08/03/06 - 20060172344 - Single chain antibody and use thereof The present invention provides a single chain antibody that retains its original specific binding activity with an antigen, and a labeled single chain antibody in which a labeling substance is bound to the single chain antibody. Specifically, the labeled single chain antibody of the present invention can be produced by ... 07/27/06 - 20060166286 - Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and azido farnesyl alcohol. The azido moiety in the resulting modified proteins provides an affinity ... 07/27/06 - 20060166285 - Charged permeation layers for use on active electronic matrix devices An electronic device including at least one electrode on a substrate and a permeation layer overlaying the at least one electrode. The permeation layer comprises a polymer having a plurality of negatively-charged moieties. The negatively charged moieties may be carboxylates. In one embodiment, the negatively charged moieties are carboxylates from ... 07/27/06 - 20060166284 - Novel tissue factor targeted antibodies as anticoagulants This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the ... 07/20/06 - 20060160151 - Method of quantitative immunohistochemistry and in situ hybridization The present invention involves a simple and rapid method for quantitative detection of a ligand in a sample using a combination of an ELISA-like assay and immunohistochemical staining. ... 06/01/06 - 20060115860 - Immunologic assay for detection of autoantibodies to folate binding protein The present invention is directed to an assay that detects autoantibodies to folate receptor and can be used in the clinical diagnostic testing of these autoantibodies in humans. Although there are other methods that exist to detect these autoantibodies, the assay described in the present invention has several features that ... 05/18/06 - 20060105401 - Diagnostic method for screening complement regulatory protein levels to predict spontaneous abortion The invention provides a method for the early detection of pregnancy failure, spontaneous abortion or premature birth by determinations of complement regulatory protein levels. A kit for use in rapid identification of these pregnancy complications is also provided. ... 05/18/06 - 20060105400 - Elisa kits for detecting collagenase 3 as a proenzyme and in an activated form in body fluids and cell culture supernatants The invention relates to ELISA kits for detecting pro-collagenase 3 and activated collagenase 3 in body fluids, especially in human serum and synovial fluid, and in cell culture supernatants, and monoclonal antibodies which specifically recognise said antigens. Said ELISA kit comprises the following separately packed elements: a) a solid carrier ... 05/11/06 - 20060099654 - Methods and kits for the determination of sirolimus in a sample Methods and kits for determining sirolimus in a sample known or suspected to contain sirolimus are provided. The methods and kits according to the invention use one or more antibodies generated using a fragment of sirolimus, such as the northern fragment of sirolimus. ... 05/04/06 - 20060094065 - Methods of analyzing a sample by maldi-mass spectrometry Methods of analyzing a sample by MALDI-mass spectrometry are disclosed. ... 03/30/06 - 20060068449 - N-terminal and c-terminal markers in nascent proteins This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Methods are described for ... 03/16/06 - 20060057647 - Detection and identification of saxiphilins using saxitoxin-biotin conjugates A method for capturing a saxiphilin to allow for detection, characterisation, isolation an/or purification of said saxiphilin or its ligand, comprising: (1) providing a PST conjugate comprising a PST moiety bound via a linker through a site other than the binding site for saxiphilin directly or indirectly to a biotin ... 02/16/06 - 20060035288 - Methods for detection of counterfeit liquids and foods The present disclosure concerns methods of detecting counterfeit liquid and/or food products, particularly those used for human consumption. In certain embodiments, the claimed methods may comprise adding two or more markers to a liquid or food product, releasing the product into a stream of commerce, obtaining one or more samples ... 02/02/06 - 20060024763 - Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass ... 01/19/06 - 20060014221 - Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma The invention relates to methods and kits for assessing occurrence in patient urine of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of mesothelioma patients. The methods and kits can be used to ... 01/19/06 - 20060014220 - Multipurpose linker compounds and ligands and process for producing the same A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, ... 01/12/06 - 20060008856 - Mass tags for quantitative analysis The present invention relates generally to novel protein modification reagents for fractionation and quantitative (differential) profiling of proteins in a complex mixture. The reagents react with amino acids or other protein components or structures and function as mass tags. The present invention provides methods of making the protein modification reagents ... 12/29/05 - 20050287607 - Methods and compositions for identification of antigen-specific b cell populations Provided are compositions and methods for identifying, enumerating and isolating B cells that react to a particular antigen. Included are tetrameric antigen-avidin complexes not comprising an MHC molecule, kits for producing the complexes, and reagents for diagnosing an autoimmune disease or monitoring progression of an autoimmune disease comprising the complexes. ... 12/22/05 - 20050282235 - Process and device for producing reagent carriers The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between a treatment device and the reagent carrier body ... 12/15/05 - 20050277160 - Peptide capable of binding to nanographite structures It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohoms or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, ... 12/15/05 - 20050277159 - Nanoparticle and microparticle based detection of cellular products Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic spectral feature. In particular, devices and methods are provided for measuring secreted cellular products including cytokines. Detection substrates, include microwells having product-specific capture reagents thereon ... 12/08/05 - 20050272100 - Separation and quantification of biotinylated macromolecules The present invention provides a biotin-binding membrane comprising covalently-linked biotin-binding agents, such as avidin and streptavidin, and a kit comprising the membrane. Also provided are methods for the detection and quantification of biotinylated molecules. ... 12/01/05 - 20050266505 - Proteomic analysis Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a compositions comprising active compounds toward a metalloproteases ... 11/24/05 - 20050260689 - Differential immunoassay The invention provides assay methods and kits that in general measure the level of a first analyte in a sample reduced by the level of a second analyte present in the same sample. In one embodiment, where levels of a first analyte from a first source is desirably determined and ... 10/27/05 - 20050239145 - Flow-through membrane assays for carbohydrates using labeled lectins The present invention comprises a method for rapid detection of at least a first carbohydrate in a carbohydrate-containing sample molecule comprising the steps of: (a) retaining the sample molecule on a region of one liquid permeable reaction membrane, (b) flowing a solution of first lectin, capable of binding the first ... 10/27/05 - 20050239144 - Site-specific labelling of proteins using cyanine dye reporters in which D is a dye selected from a cyanine dye or a derivative thereof; B is an affinity tag; F comprises a target bonding group selected from a carboxylic acid thioester group and a 1,2-aminothiol group; M is a group adapted for attaching to F; and L1 and L2 ... 10/20/05 - 20050233389 - Methods and compositions for peptide and protein labeling The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ biotin ligase and biotin analogs. ... 10/13/05 - 20050227299 - Fluorescent dyes (aida) for solid phase and solution phase screening which can be used in high throughput screening both, on the solid phase as well as in homogeneous solution. ... 09/29/05 - 20050214875 - Metal chelate containing compositions for use in chemiluminescent assays Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom ... 09/22/05 - 20050208598 - Biotin recognition sensors and high-throughput assays In one embodiment is provided a new class of biotin recognition sensors which comprise a biotin recognition compound (containing a biotin binding moiety), a fluorescent donor moiety, and an acceptor moiety. These compounds are useful for detecting biotin in a sample or on a carrier molecule. In addition to compounds, ... 09/08/05 - 20050196814 - Human suppressor of fused The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present ... 09/01/05 - 20050191710 - Method for labeling a membrane-localized protein The present invention relates to a method for labeling a membrane-localized protein by introducing a biotin target sequence tag into at least one loop domain of a membrane-localized protein. The method of the invention is useful for labeling an ion channel protein such as CFTR or mutants thereof. A method ... 08/25/05 - 20050186641 - Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers. ... 08/11/05 - 20050176071 - Homogeneous assay methods The present invention provides a method of assaying for kinase activity, comprising contacting a fluorescently labeled phosphorylatable peptide substrate with an ATP analog in the presence of a kinase enzyme to yield a first product; contacting the first product with a reactant that comprises a biotin derivative to yield a ... 08/11/05 - 20050176070 - Protein analysis A method of forming an array of proteins selected from antigens or antibodies; said method comprising the steps of (i) expressing in a recombinant cell, a fusion protein which comprises either (a) an antigen or (b) an antibody binding protein, fused to a peptide having up to 50 amino acids, ... 07/28/05 - 20050164311 - Biological assay detection method The invention is a method for detecting a reaction product which signals the presence of a reaction product inducer such as an enzyme. The method enables the recognition of epitopes that form the basis of a detection strategy without the need for specific antibodies to the epitope. In the method, ... 07/21/05 - 20050158804 - Site-specific labelling of proteins An in vivo method for labelling a protein having an N-terminal cysteine is disclosed. A probe comprising a thioester group and a detectable label is introduced into a cell expressing the N-terminal cysteine protein, allowing for the N-terminal cysteine to cleave the thioester bond and resulting in the label being ... 07/14/05 - 20050153371 - Conjugated small molecules Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or ... 06/23/05 - 20050136491 - Method of site specific labeling of proteins and uses therefor Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents ... 06/16/05 - 20050130235 - Method and compositions for the detection of protein glycosylation The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits ... ### FreshPatents.com Support |