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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay > Involving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial Lysate Involving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial LysateInvolving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial Lysate patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087391 - Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the ... 04/19/07 - 20070087390 - Opiate, cannabinoid, and estrogen receptors The present invention relates generally to mu3 opiate receptors, cannabinoid receptors, and estrogen surface receptors (ESRs). Specifically, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists, cannabinoid receptor agonists and antagonists, and ESR agonists and antagonists. In addition, the invention provides an isolated nucleic acid ... 04/12/07 - 20070082369 - Method for production and use of mite group 1 proteins The present invention includes a method to produce a recombinant mite Group 1 protein in a methyltrophic yeast or an Escherichia coli microorganism. The present invention also relates to a recombinant mite Group 1 protein obtained by such a method, such a recombinant protein being able to selectively bind IgE ... 04/12/07 - 20070082368 - Human cell clones useful for functional analyses of the biological activity of an endogeneous urotensin ii receptor and uses thereof Human cell clones with increased specific binding to urotensin II have been sub-cloned from SJRH30 (ATCC® Number: CRL-2061™). These cell clones have been used for functional analyses of the biological activity of an endogeneous urotensin II receptor, as well as for identifying compounds that regulate the biological activity of an ... 04/12/07 - 20070082367 - Methods of purifying anti a beta antibodies The present application provides methods of purifying Aβ binding proteins having a Fc region, for example, anti-Aβ antibodies or antibody fusions, by adsorbing the Aβ binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt ... 04/12/07 - 20070082366 - Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio The present invention is directed to methods of diagnosing Alzheimer's disease in a subject by detecting alterations in the ratio of specific phosphorylated MAP kinase proteins in cells after stimulation with a protein kinase C activator. The Alzheimer's disease-specific molecular biomarkers disclosed herein are useful for the diagnosis of Alzheimer's ... 04/05/07 - 20070077602 - Gpr35 and modulators thereof for the treatment of metabolic-related disorders The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: a) contacting a candidate compound with GPR35, and b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates ... 04/05/07 - 20070077601 - Reagent kit fr determining characteristic of tissue A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents ... 04/05/07 - 20070077600 - Methods and kits for distinguishing between specific and non-specific protein associations The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific. The method comprises (a) providing a first sample of the cells in which the given protein contains a tag, (b) providing a second sample of the same ... 03/29/07 - 20070072249 - Human cytokine and alpha-helix-containing polypeptides This invention relates to new human alpha-helix-containing polypeptides, to methods of making such polypeptides, to methods of using them to treat immunological conditions, and to methods of identifying compounds that alter alpha-helix-containing polypeptide activities. ... 03/29/07 - 20070072248 - Constitutively activated human g protein coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity. ... 03/29/07 - 20070072247 - Methods and reagents for the analysis and purification of polysaccharides The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions. Polysaccharide compositions include those isolated from Ganoderma lucidum (Reishi). The methods ... 03/29/07 - 20070072246 - Cell-based assays for determining drug action Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify ... 03/29/07 - 20070072245 - Method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs The invention relates to a method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs, especially for the diagnosis of pregnancy and diagnosis of embryo-implantation. In a biological sample, the concentration of human endometrial chorionic gonadotropin ... 03/29/07 - 20070072244 - Use of the endo-180 gene and polypeptide for diagnosis and treatment This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of ... 03/29/07 - 20070072243 - Multiplex screening for lysosomal sotrage disorders (lsds) A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against ... 03/22/07 - 20070065885 - Methods for shp1 mediated neuroprotection The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level ... 03/22/07 - 20070065884 - Mammalian sour/acid taste and csf receptor genes, polypeptides and assays Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, antibodies to the receptors, methods of detecting polymorphisms, and methods of correcting taste defects are also provided. ... 03/22/07 - 20070065883 - Molecules that modulate galphaq activity and methods of treating urinary incontinence The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods. ... 03/22/07 - 20070065882 - Acetylcholinesterase-derived peptides and uses thereof The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting ... 03/22/07 - 20070065881 - Isolated cytotoxic factor associated with multiple sclerosis and method of detecting said cytotoxic factor The invention relates to an isolated cytotoxic factor which is associated with multiple sclerosis and which is selected from the heterocomplex GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14, and to the method of detecting said factor in a biological sample to be tested. The inventive method comprises the following steps consisting in: (i) ... 03/15/07 - 20070059779 - Biocatalytic solgel microarrays A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte. ... 03/15/07 - 20070059778 - Modified colony assay Improved colony forming cell (CFC) assays are described. The improved assay comprises modifications to the standard CFC assay that enable analysis of temporal, real-time changes in antigen expression during colony development without need to fixate or destroy the culture. The improved assay is applicable to hematopoietic CFC assays as well ... 03/15/07 - 20070059777 - Thrombin-induced fibrinogen binding for the detection of risk of bleeding disorders This invention provides a methods of detecting a bleeding disorder in mammals where the bleeding disorder is characterized by normal fibrinogen binding to ADP-activated platelets, but decreased fibrinogen binding to thrombin-activates platelets. ... 03/15/07 - 20070059776 - Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of ... 03/15/07 - 20070059775 - Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and mr imaging techniques The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the ... 03/15/07 - 20070059774 - Kits for prenatal testing The invention relates to a kit for prenatal testing comprising a size-based separation module which enriches a first cell type from a maternal blood sample found in vivo in a pregnant female at a concentration of less than 1% of all blood cells, and a set of instructions for analyzing ... 03/15/07 - 20070059773 - Identification of therapeutic compounds Methods for identifying potential therapeutic agents involve determining the affinity and/or efficacy of a test compound for an adensoine receptor at a relatively high pH and at a relatively low pH. Compounds with greater affinity and/or efficacy at the low pH are identified as potential therapeutic agents, in particular for ... 03/08/07 - 20070054325 - Materials and methods for screening modulators of neural regeneration The invention provides materials and methods used to identify modulators of neurogenesis and neuroregeneration, and use of said modulators in the treatment of neurodegenerative diseases and neurological injury. ... 03/08/07 - 20070054324 - Cat1 transporters expressed in blood brain barrier cells CAT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the CAT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in ... 03/08/07 - 20070054323 - Oct3 transporters expressed in blood brain barrier cells OCT3 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OCT3 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in ... 03/08/07 - 20070054322 - Methods and kits for the detection of prion diseases The present invention relates to a method for the diagnosis of a neurodegenerative disorder in a mammalian subject. The method of the invention comprises the steps of (a) providing a body fluid sample of said subject; (b) concentrating proteins comprised within said sample by a suitable means; (c) contacting the ... 03/08/07 - 20070054321 - Methods of diagnosing and treating inflammatory diseases using pac-1 (dusp2) The present invention relates generally to the diagnosis and treatment of inflammatory diseases such as rheumatoid arthritis and asthma in humans and other animals. The invention also relates to a method for identifying agonists and antagonists of the enzyme PAC-1 (DUSP2) that are useful in the therapeutic methods described herein. ... 03/01/07 - 20070048806 - Microarrays on mirrored substrates for performing proteomic analyses Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library synthesis, distribution, and spotting of array elements onto solid planar substrates, labeling of ... 03/01/07 - 20070048805 - Methods of using zven antibodies The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The ... 03/01/07 - 20070048804 - Methods of detecting cytokine receptor zcytor19 ligand Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor ... 03/01/07 - 20070048803 - Immune profiling of lymph nodes associated with cancer Cancers are phenotyped by analysis of the presence of immune cells, particularly T cells and dendritic cells, present in regional lymph nodes. When non-sentinel regional lymph nodes of a cancer patient are compared to normal lymph nodes, it is found that increased number of dendritic cells and decreased numbers of ... 03/01/07 - 20070048802 - Method and kit for detection of autoimmune chronic urticaria Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic ... 03/01/07 - 20070048801 - Cxcr3 is a gliadin receptor Gliadin is identified as a physiological receptor for CXCR3. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling can be determined. Methods for treating diseases relating to gluten and/or autoimmunity by targeting CXCR3 are provided. Such diseases include celiac disease, ... 02/22/07 - 20070042437 - Diagnosis and treatment of alzheimer's disease This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream signaling molecules. The invention further relates to methods for the treatment of AD by administering an insulin agonist and an insulin-like growth factor agonist. ... 02/22/07 - 20070042436 - Cd38 modulated chemotaxis The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, ... 02/22/07 - 20070042435 - Assays for sensory modulators using a sensory cell specific g-protein beta subunit The invention identifies nucleic acid and amino acid sequences of sensory specific G-protein beta subunits that are specifically expressed in sensory cells, antibodies to such subunits, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific beta subunits. ... 02/22/07 - 20070042434 - Method for identifying tff2 regulating agents and agents identified using said method Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ.ID. NO. 1 and SEQ.ID. NO. 2; a nucleotide ... 02/22/07 - 20070042433 - Neuregulin protein regulation of synaptic proteins FSTPEELQARLSSVIANQDPIAV ... 02/22/07 - 20070042432 - Method of diagnosis and treatment The present invention relates generally to a method for detecting an aberrant cell, and more particularly an apoptotic cell, in a subject or in a biological sample from said subject, and agents useful for same. The presence of the aberrant cell or group of aberrant cells provides an indication of ... 02/15/07 - 20070037222 - Lineage restricted glial precursors Glial precursor cell populations from mammalian central nervous system and embryonic stem cells has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP ... 02/15/07 - 20070037221 - Diagnosis of liver pathology through assessment of protein glycosylation Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease ... 02/15/07 - 20070037220 - Biomolecule specificity detection and selection method and apparatus We disclose a method of detecting a polypeptide of interest produced by a cell or a cell colony, the method comprising: (a) exposing the polypeptide to a class marker capable of identifying a class of polypeptides to which the polypeptide of interest belongs; (b) exposing the polypeptide to a specificity ... 02/15/07 - 20070037219 - Rhesus monkey bombesin receptor subtype-3 (brs-3), nucleotides encoding same, and uses thereof A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or ... 02/08/07 - 20070031897 - Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-trp Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells ... 02/08/07 - 20070031896 - Anti-ccr4 antibodies and methods of use therefor The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a ... 02/08/07 - 20070031895 - Glans compatible single unit semen collection and storage device, kit and related methods of use A method and device to conform with the glans penis to recover ejaculated semen completely, to prevent the loss of initial sperm rich epididymal fractions, to avoid the use of a condom for masturbation, to eliminate the multi-step transfers of semen following ejaculation that are common with current methods, and ... 02/08/07 - 20070031894 - Novel nerve stem cell marker It is an object of the present invention to provide a method for detecting nerve stem cells/progenitor cells among a tissue or a mass of cells as constituted of a plurality of cell species, and a method for screening for a drug functioning as a nerve differentiation factor or the ... 02/01/07 - 20070026465 - Method for detecting gad65 autoreactive t cells newly diagnosed type1 diabetic patients and in the prediabetic period The invention refers to a method for detecting GAD65 specific T cells in a biological sample useful for the prediction of T1D onset, and/or to follow up the effects of therapeutics and in particular of specific immunotherapies in the pre-clinical period of the disease. ... 01/25/07 - 20070020698 - Igf binding proteins IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided. ... 01/25/07 - 20070020697 - Virtual flow cytometry on immunostained tissue-tissue cytometer The invention provides an automated method of single cell image analysis which determines cell population statistic, applicable in the field of pathology, disease or cancer diagnosis, in a greatly improved manner over manual or prior art scoring techniques. By combining the scientific advantages of computerized automation and the invented method, ... 01/25/07 - 20070020696 - Appl proteins as rab5 effectors The present invention relates to an in vivo-assay to screen for anti-proliferative drugs, the assay comprising the steps of: (a) contacting cells of a primary cell culture or of an established cell line with a candidate substance, (b) subsequently or concomitantly with a candidate substance, contacting the cells with a ... 01/18/07 - 20070015221 - Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry. ... 01/18/07 - 20070015220 - Novel guanosine triphosphate (gtp) binding protein-coupled receptor proteins A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable ... 01/18/07 - 20070015219 - Tnf receptor-like molecules and uses thereof Novel MK61 polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing MK61 polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with MK61 polypeptides. ... 01/18/07 - 20070015218 - A method for the separation anti-amyloid beta antibody with amyloid beta peptide The present invention is a method of effectively dissociating an antibody and antigen from the complex they form. The method enables researchers to accurately identify anti-amyloid beta peptide and its antibody from sera samples. It can also be used for the evaluation of the outcome of Alzheimer's patient treatment based ... 01/18/07 - 20070015217 - Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein ... 01/11/07 - 20070009967 - Methods for shp1 mediated neuroprotection The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level ... 01/11/07 - 20070009966 - Method for identification of somatic stem cells The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at ... 01/11/07 - 20070009965 - Novel method for screening for gpcr agonists and/or antagonists from herbs The present invention provides a novel method of using an herbal chip for screening for candidate compounds as a GPCR agonist or antagonist from herbs by using a labeled anti-GPCR-GPCR as a probe for hybridization. ... 01/11/07 - 20070009964 - Ox40r binding agents The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with ... 01/04/07 - 20070003986 - Methods for identifying compounds for treating diabetes mellitus The invention is directed to methods for identifying candidate beta cell-sensitizing compounds comprising providing a pancreatic beta islet cell population derived from a diabetic subject, contacting the beta islet cell population with one or more somatostatin receptor 5-binding compounds, and identifying those somatostatin receptor 5-binding compounds that promote insulin secretion ... 01/04/07 - 20070003985 - Specific mucin expression as a marker for pancreatic cancer Methods are provided for the diagnosis of pancreatic cancer. ... 01/04/07 - 20070003984 - Method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin The invention relates to a method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin and/or a tissue sample of skin-neighboured-mucosa, wherein the spatial arrangement of epitopes in the sample is captured for identifying the disease-specific combinatorial molecular pattern motif. The invention ... 01/04/07 - 20070003983 - Activated forms of notch and methods based thereon The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a ... 01/04/07 - 20070003982 - Analyzing nerve cell damage Methods for detecting a cell damage relate to the discovery that proteases are selectively activated in subjects suffering from nervous system damage compared to samples from healthy subjects. Breakdown products reflecting activation of proteases that degrade spectrin are produced. A cell injury is detected by providing a biological sample derived ... 12/28/06 - 20060292640 - Diagnostic methods for the detection of risk of neurodevelopmental disorders The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, ... 12/28/06 - 20060292639 - Splice variant of the vanilloid receptor vr1a The invention provides a splice variant of the vanilloid receptor termed “VR1A.” VR1A has a unique N-terminus as compared with wild type VR1. The invention provides nucleic acid sequences encoding VR1A, expression vectors for expressing VR1A, amino acid sequences of VR1A, antibodies against VR1A and methods of making and using ... 12/21/06 - 20060286609 - Rabbit monoclonal antibody against id1 protein The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id1 protein and/or mouse Id1 protein, equal to or greater than 1×108/molar. The antibody ... 12/21/06 - 20060286608 - Method for screening transglutaminase 2 inhibitor or activator Disclosed herein is a method for screening a TGase 2 inhibitor or activator, based on the finding that TGase 2-induced NF-κB activation is attributed to the polymerization of I-κBα, in which the level of free or polymerized I-κBα proteins or the level of NF-κB is measured to determine the TGase ... 12/14/06 - 20060281137 - Method of the discrimination and isolation of mammary epithelial stem and colony-forming cells The present invention relates to an improved method that permits the differential isolation of mouse mammary stem cells and colony forming cells (CFCs). The method involves depletion of non-epithelial cells from freshly dissociated mouse mammary tissue by incubation with an antibody composition containing antibodies specific for CD45, Ter119, CD35 and ... 12/14/06 - 20060281136 - Preparation of endodermal stem cells It is intended to prepare endodermal stem cells by differentiation from multipotential stem cells followed by isolation. This object can be achieved by separating various endodermal stem cells having been differentiated from multipotential stem cells with the use of, as indications, a specific cell surface marker, an organizer-specific marker and ... 12/07/06 - 20060275840 - Support and method for cell based assays Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different populations of cells adhering to ... 12/07/06 - 20060275839 - Genes We describe two primordial germ cell-specifically expressed genes, GCR1 (Fragilis) and GCR2 (Stella), as well as their fragments, homologues, variants or deriviatives thereof which are markers for primordial germ cells and may be used to identify such cells in cell populations. ... 12/07/06 - 20060275838 - Compositions and methods for inhibiting liver stellate cell growth The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocytes as containing a death factor that induces apoptosis of activated liver stellate cells. This pro-apoptotic ... 12/07/06 - 20060275837 - Compositions and methods for assaying herg channel binding The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a selenium analog of a competitive inhibitor of the ... 12/07/06 - 20060275836 - Methods of identifying respondents to hypoxia inducible factor 1-alpha inhibitors This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates ... 12/07/06 - 20060275835 - Methods for identifying cell surface receptor protein modulators The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a target cell surface protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those ... 12/07/06 - 20060275834 - Methods and compositions related to joint inflammation diseases Disclosed are compositions and methods related to joint inflammation diseases. Disclosed is the relationship between osteoclasts and inflammatory joint diseases and osteoclast cells. ... 12/07/06 - 20060275833 - Methods for the identification of agents that modulate the structure and processing of a membrane bound precursor protein The present invention provides methods for the screening and identification of agents from a large library of molecular structures that can alter the cleavage of a membrane protein of interest. Agents identified by the methods of the present invention that modify the cleavage of the membrane protein can be used ... 12/07/06 - 20060275832 - Methods of screening cyclic peptides and identifying targets therefor The present invention provides compositions and methods for identifying candidate compounds capable of altering a phenotype of a cell that mediate their activity by binding with a specific chaperone of interest. Also provided are methods and compositions for identifying the target of the candidate compound-chaperone complex. ... 11/30/06 - 20060269969 - Screening for cell-targeting ligands attached to metal nanoshells for use in target-cell killing Disclosed is a screening method for detecting cells producing binding agents, including Monoclonal Antibodies, which bind to particular antigens on cells or organisms such that, when the binding agents are bound to said antigens, a nanoshell or metal colloid coupled to the binding agents is capable, upon illumination with a ... 11/30/06 - 20060269968 - Method of assessing the effectiveness of a treatment regimen The present invention provides materials and methods to assess the efficacy of a treatment. In some embodiments, the present invention provides a method of assessing the efficacy of a treatment for celiac disease by measuring the serum zonulin level of a subject having received the treatment. ... 11/30/06 - 20060269967 - Novel diagnosis & treatment tools for cancer using the nrip antibody and rna interference The invention provides an isolated nucleic acid encoding NRIP (Nuclear Receptor Interaction Protein) gene that highly expressed in tumorigenic development of human neoplasms in cervical cancer. The invention provides an antibody against the NRIP protein, and methods of diagnosing the NRIP related cancer. The invention also features RNA interferences of ... 11/23/06 - 20060263831 - Interfacial biomaterials for binding ceramic substrates An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided Is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including ... 11/23/06 - 20060263830 - Interfacial biomaterials An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including ... 11/23/06 - 20060263829 - Efficient haploid cell sorting flow cytometer systems A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to ... 11/23/06 - 20060263828 - Modified trafficking patterns for arrestin and g-protein-coupled receptors via arrestin-ubiquitin chimera The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a ... 11/23/06 - 20060263827 - Novel endothelial cells, antibodies directed against said cells and use thereof, in particular for screening angiogenesis inhibiting substances The invention concerns the use of a binary set comprising: endothelial cells of non-angiogenic phenotype and endothelial cells of angiogenic phenotype, for screening substances angiogenic towards endothelial cells of non-angiogenic phenotype, not substantially affecting substantially the of angiogenic phenotype endothelial cells of angiogenic phenotype, or substances angiogenic towards endothelial cells ... 11/16/06 - 20060257944 - System and method for automated selection of t-cell epitopes Methodology for the automated selection and/or optimization of T-cell epitopes is disclosed. The invention provides a data processing system which utilizes sequence-based statistical pattern recognition to compute an epitope selection matrix based on the informational content of epitopes known to bind to a particular major histocompatibility class I allele. The ... 11/16/06 - 20060257943 - Ischemic biomarkers and their use to predict adverse neurological events from surgery Methods are provided for predicting the occurrence of adverse neurological events from surgery. Such adverse events include, for example, stroke, delirium and transient ischemic attack (TIA). The methods are based on the discovery that levels of circulating cerebral NMDA receptor peptides and antibodies can be used to identify patients who ... 11/16/06 - 20060257942 - Protein subcellular localization assays using split fluorescent proteins The invention provides protein subcellular localization assays using split fluorescent protein systems. The assays are conducted in living cells, do not require fixation and washing steps inherent in existing immunostaining and related techniques, and permit rapid, non-invasive, direct visualization of protein localization in living cells. The split fluorescent protein systems ... 11/16/06 - 20060257941 - Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or ... 11/09/06 - 20060252104 - Methods of selecting compounds for modulation of bladder function The present invention involves an assay system and method of selecting compounds useful in the treatment of bladder instability and related bladder conditions through the activation of KCNQ potassium channels in the bladder smooth muscle. ... 11/09/06 - 20060252103 - Novel assay for screening antipsychotic drugs A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal cell lines effect for it to predict the extrapyramidal symptoms that may be induced by an antipsychotic without having to carry ... 11/09/06 - 20060252102 - Assays for c-mannosyltransferases This invention provides cell-based assays for detecting C-mannosyltransferase (CMT) activity and screening assays for agents effective in modulating CMT activity. ... 11/09/06 - 20060252101 - Modulators and modulation of the interaction between rgm and neogenin This invention relates to drug screening using mammalian repulsive guidance molecules and mammalian Neogenin. In addition, the invention provides for methods of preventing, alleviating or treating various disorders of the nervous system, angiogenic disorders or disorders of the cardio-vascular system and malignancies of different etiology by disrupting the interaction between ... 11/02/06 - 20060246517 - Epitope protection assay The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent ... 11/02/06 - 20060246516 - Method for detecting perilymphatic fistula It is an object of the present invention to provide a simple, reliable and low-invasive method to detect perilymph fistulas. The present invention provides a method for detecting a perilymph fistula, which comprises detecting the existence of Cochlin in body fluid existing in the middle ear. ... 10/26/06 - 20060240486 - Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies In various aspects, the present invention provides methods and kits for predicting the therapeutic efficacy of an immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder by comparing the amount of Aβ monomer in an Aβ preparation which binds to the ... 10/26/06 - 20060240485 - Method of monitoring immunotherapy The present invention relates to a method of monitoring an immunotherapy against amyloidosis and other diseases characterized by the deposition of abnormal protein aggregates. More specifically, it relates to a method of evaluating an immunotherapy against Alzheimer's disease, based on a novel assay that is characterized by scoring immunoreactivity levels ... 10/26/06 - 20060240484 - Protein for diagnosing diabetic retinopathy The present invention relates to material for diagnosing Diabetic retinopathy. More particularly, the present invention relates to Immunoglobulin A protein for diagnosing Diabetic retinopathy, kit for diagnosing Diabetic retinopathy comprising antibody against the protein and method for diagnosing Diabetic retinopathy. The present invention can be used as diagnosing Diabetic retinopathy. ... 10/26/06 - 20060240483 - Method and kit for monitoring recruitment of proteins to the intracellular domain of a receptor in intact cells The present invention relates to an immunological method and kit for monitoring recruitment of a protein to the intracellular domain of a receptor in intact cells. ... 10/19/06 - 20060234313 - Modulation of angiogenesis through targeting of arginyl transferase (ate1) The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of N-terminal arginylation activity. The invention also provides a method of identifying such a modulator and a method of in vitro screening for ... 10/19/06 - 20060234312 - Detection of surface-associated human leukocyte elastase In order to accurately and reliably quantitate HLE on the plasma membranes of the lymphocytes and mononuclear phagocytes, a test sample containing the lymphocytes and mononuclear phagocytes is initially treated with a first antiserum specific for CD4 receptors on the plasma membrane or with a second antiserum specific for chemokine ... 10/19/06 - 20060234311 - Isolating cells expressing secreted proteins A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; ... 10/19/06 - 20060234310 - Enriched antigen-specific t-cells and related therapeutic and prophylactic compositions and methods T-cell responses are initiated via contact with MHC/peptide complexes on antigen presenting cells (APCs). The fate of these complexes, however, is unknown. Here, using live APCs expressing MHC class I molecules fused with green-fluorescent protein, we show that peptide-specific T-cell/APC interaction induces clusters of MHC I molecules to congregate within ... 10/19/06 - 20060234309 - Quality assays for antigen presenting cells The present invention provides methods for evaluating the quality of a preparation of antigen presenting cells, such as dendritic cells. Assays for antigen-independent co-stimulation of T cells and for presentation of predetermined antigen by APC's are provided. ... 10/05/06 - 20060223124 - Amphiphilic mediated sample preparation for micro-flow cytometry A flow cytometer includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the oil phase and the water phase, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit ... 10/05/06 - 20060223123 - Rhesus monkey nur77 The Macaca mulatta (rhesus monkey) Nur77 (rhNur77) nuclear receptor and the nucleic acid encoding the rhNur77 nuclear receptor are described. Further described are methods for identifying analytes that modulate expression or activity of the rhNur77 nuclear receptor. Analytes that affect Nur77 expression or activity may be used to treat or ... 10/05/06 - 20060223122 - Classifying and predicting glomerulosclerosis using a proteomics approach The present invention provides for a proteomic approach to classifying glomerular tissue as normal, non-sclerotic or sclerotic. In particular, the proteomic approach may employ laser capture microdissection followed by MALDI-TOF. A particular target of interest that is highly relevant in distinguishing such tissues is thymosin β4. ... 09/28/06 - 20060216758 - Antibodies to transferrin receptor-like proteins The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of ... 09/28/06 - 20060216757 - Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one βc Receptor. These compounds used in the assays to identify ... 09/28/06 - 20060216756 - Method for evaluating oxidized protein in horny cell layer The invention provides a method for two-dimensional evaluation of the nature of horny layer oxidized protein on a horny layer, the method comprising specific fluorescent labeling of the carbonyl groups of the oxidized protein in a horny layer specimen taken from skin, and detection of the fluorescence for evaluation, as ... 09/21/06 - 20060211053 - Selecting therapeutic human monoclonal antibodies for disease-specific libraries The invention relates to a method of generating human monoclonal antibodies suitable as therapeutic candidates from a pool of human peripheral blood lymphocytes extracted from a number of individuals who have all been exposed to the same disease antigen. Peripheral blood lymphocytes extracted from said individuals are immortalized, and a ... 09/21/06 - 20060211052 - Screening antibodies using an optical fiber array device capable of simultaneously performing multiple functional assays Disclosed is a method of screening binding molecules, including Monoclonal Antibodies, using an optical fiber array device. Target cells are coated onto a population of microbeads, wherein each microbead is coated with several cells of the same cellular type and has an assay and an assay reporter associated with it. ... 09/21/06 - 20060211051 - Methods and reagents for preparing and using immunological agents specific for p-glycoprotein This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific ... 09/07/06 - 20060199229 - Methods for identification of modulators of osgpr116 activity, and their use in the treatment of disease This invention relates to the identification of fatty acid or lipid amides that decrease food intake in mammals, including fatty acid ethanolamides, as ligands for the G-protein coupled receptor OSGPR116, and describes the first demonstration of a specific G-protein coupled receptor that is activated by fatty acid ethanolamides that inhibit ... 09/07/06 - 20060199228 - Peptides for treatment of autoimmune diseases Peptides for use in the therapy or prevention of Type 1 Diabetes mellitus (T1DM) are those having sequences containing QPLALEGSLQK (SEQ ID NO: 9). Examples are those having a sequence selected from the group consisting essentially of GGGPGAGSLQPLALEGSLQK (SEQ ID NO: 4), GSLQPLALEGSLQKRGIV (SEQ ID NO: 5), and QPLALEGSLQKRGIVEQ (SEQ ... 09/07/06 - 20060199227 - Phuman t2r receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of ... 08/31/06 - 20060194261 - Methods for determining cellular response to stimuli The present invention provides a method for determining cellular response to stimuli. The cells to be tested, for example, may be contained in a section of taste-bud containing lingual epithelium. ... 08/31/06 - 20060194260 - Screening assays for cannabinoid-ligand-type modulators of gpr55 Screening assays for compounds that modulate the interaction between cannabinoids and the GPR55 receptor are disclosed. Furthermore, a method for determining the selectivity of a test compound against a panel of cannabinoid receptors including GPR55 is disclosed. ... 08/31/06 - 20060194259 - Method for isolating an allosteric effector of a receptor A method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between the receptor and one of its ligands in the presence of the allosteric effector, as compared to the kinetics dissociation, in the absence of the effector, and/or ... 08/24/06 - 20060188946 - Nanobio device of imitative anatomy structure objects to be achieved by the invention are to provide a nanobio device in which cultured cells are organized at a high-level in a state near in vivo, and to provide a method of using the nanobio device of imitative anatomy structure. The nanobio device of imitative anatomy structure of ... 08/24/06 - 20060188945 - Screening methods The present invention relates to methods for the identification of modulators of cytokine class I receptors by determining whether a compound that binds to a cytokine class I receptor at a site different from the binding site of the naturally-occurring cytokine ligand is effective at modulating the amount of the ... 08/24/06 - 20060188944 - Methods of assaying receptor activity Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. ... 08/17/06 - 20060183164 - Non-endogenous, constitutively activated known g protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification ... 08/17/06 - 20060183163 - Methods and compositions for screening for modulators of ige synthesis, secretion and switch rearrangement The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement. ... 08/17/06 - 20060183162 - Novel markers for alternatively activated macrophages The present invention relates to novel markers for alternatively activated macrophages. More specifically, the present invention relates to the use of galactose-type C-type lectins as surface markers that allows rapid identification and sorting of the alternative macrophages. Such identifications can be useful in diseases where there is an imbalance between ... 08/17/06 - 20060183161 - Il-ili gene and polypeptide products The present invention relates to the discovery of novel genes encoded by the interleukin-1 locus. The IL-1L1 gene is located in the interval between the IL-1Beta and the IL-1 receptor antagonist encoding genes and encodes a polypeptide which is homologous to both IL-1 agonist and IL-1 antagonist proteins. Therapeutics, diagnostics ... 08/10/06 - 20060177878 - Animal cell colony picking apparatus and method An apparatus and method for automated picking of animal cell colonies. A picking head comprising a plurality of hollow pins is provided. The apparatus has an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations ... 08/10/06 - 20060177877 - Methods for identifying combinations of entities as therapeutics The invention features a method of screening two-entity or higher order combinations for biological activity using combinational arrays. The method includes the steps of: (a) providing the entities, (b) creating an array of combinations of entities, (c) providing a test element that includes one or more distinct biological moieties, (d) ... 08/10/06 - 20060177876 - Monoclonal antibody against asialo alpha 1-acid glycoprotein, immunochromatographic strip comprising the monoclonal antibody, and method for diagnosing liver diseases using the immunochromatographic strip The present invention relates to a method for diagnosing a liver disease rapidly in an early stage. More particularly, the present invention relates to a monoclonal antibody against asialo α1-acid glycoprotein; a method for diagnosing a liver disease which evaluates asialo α1-acid glycoprotein in a test sample by using said ... 08/10/06 - 20060177875 - Tryptase polypeptide and uses thereof The present invention provides a purified expressed δ tryptase polypeptide or fragment or analogue thereof, in particular, the human δ tryptase polypeptide or fragment or analogue thereof. The present invention also provides variants of such polypeptides. The invention further relates to methods of diagnosing disease states based on expression of ... 07/27/06 - 20060166283 - Means for detecting neurodegenerative processes and applications of same The invention relates to novel markers of the neurodegenerative process, comprising the α chain of the modified ATP synthase. The invention also relates to methods of detection, diagnosis, antibodies, kits and applications of same. ... 07/27/06 - 20060166282 - Methods and compositions for screening cell binding molecules Ligands, such as antibodies, are screened for binding to cell surface moieties such as receptors. Multiple cell types and/or binding ligands can be screened simultaneously in multiplexed assays. The screening assays employ membrane-anchored electrophoretic probes for detection of binding of the ligand to the cell surface. ... 07/27/06 - 20060166281 - Potent, selective and non toxic c-kit inhibitors The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more particularly compounds selected to be potent inhibitors of constitutively activated c-kit, while being unable to inhibit other activation pathways as for example the pathways leading ... 07/20/06 - 20060160150 - Immunoassays for brain natriuretic propeptide Immunoassays for the biological precursor of human brain natriuretic peptide are described. ... 07/20/06 - 20060160149 - G-coupled receptor showing selective affinity for atp The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention ... 07/20/06 - 20060160148 - Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the ... 07/20/06 - 20060160147 - Recombinant cell line The invention relates to a recombinant cell line capable of inducible expression of an α and/or β subunit of interleukin 12 (IL-12), and an ecdosymeinducible expression vector capable of transfecting a host cell to produce the recombinant cell line of the invention. The invention also relates to a method of ... 07/20/06 - 20060160146 - Method of screening compound affecting amyloid beta production It is intended to provide a material for efficiently measuring the production of β-amyloid which relates to the onset of Alzheimer's type dementia, and a method of efficiently screening a substance affecting the production of β-amyloid by using the above material. ... 07/13/06 - 20060154307 - Receptor assay The present invention relates to receptor/reporter fusion protein based assays for detecting an effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assays as having interesting/useful effects. Suitable membrane receptors are growth factor ... 07/13/06 - 20060154306 - Methods detecting, characterising and monitoring hydrocarbon reservoirs The present invention relates to a method of detecting, characterizing or monitoring a hydrocarbon source, which method comprises the genotypic analysis of a sample for the presence of one or more thermophilic or extemophilic microorganisms and in particular to the generation of microbiological profiles of samples and to the comparison ... 07/06/06 - 20060148007 - Method for using division arrested cells in screening assays Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays. ... 07/06/06 - 20060148006 - Assay solution compositions and methods for gpcr arrays Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of ... 06/29/06 - 20060141541 - Method of detecting or diagnosing of a neurodegenerative disease or condition A neurodegenerative disease or condition is diagnosed in a subject by obtaining a sample of cerebral spinal fluid from the subject and assaying the sample by an assay method that detects the presence of at least one antiphospholipid autoantibody in the sample, wherein an elevated level of at least one ... 06/29/06 - 20060141540 - Direct selection of cells by secretion product Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted and released. The product-labeled ... 06/29/06 - 20060141539 - Miniaturized cell array methods and apparatus for cell-based screening The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal information about changes in physiological, biochemical and molecular activities. ... 06/29/06 - 20060141538 - Automatic large-scale screening of cells secreting monoclonal antibodies The invention relates to an automatic method for the large-scale in vitro screening of cells, secreting at least one specific monoclonal antibody with affinity for a compound of interest, comprising: (10) distribution of antibody-producing cells on at least one culture plate, (12) culturing of said cells, (14) iterative screening of ... 06/22/06 - 20060134707 - Monoclonal and polyclonal antibodies to equine hemoglobin and apparatus and methods using the antibodies and/or peroxidase reactions in the identification and localization of ulcers in equines A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine globin and hematin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers in horses. Fecal droppings from a horse to be tested ... 06/22/06 - 20060134706 - Atopic dermatitis inducer An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters ... 06/22/06 - 20060134705 - Cvd assay An assay method for the detection of potential for CVD or propensity to CVD in a human or non-human animal subject, said method comprising assessing the concentration of calprotectin in a calprotectin-containing sample taken from said subject. ... 06/22/06 - 20060134704 - Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes A microwell array chip that has multiple microwells and is employed to contain a single lymphocyte specimen in each microwell and detect antigen-specific lymphocytes in single units; wherein the microwell array chip is of a shape and of dimensions where only one lymphocyte is contained in each microwell. A method ... 06/15/06 - 20060127956 - Quality control for cytochemical assays A method and device is described for a quality control device for immunohistochemical testing of surgical biopsies. Immunohistochemistry testing involves the use of antibodies to detect the presence of proteins that have diagnostic or prognostic importance. In this invention, peptides are covalently attached to glass microscope slides. The peptides represent ... 06/15/06 - 20060127955 - Assay for autoantibodies to folate receptors The present invention identifies autoantibodies to folate receptors. Methods to identify these autoantibodies to the human folate receptors are also provided. The present invention also contemplates diagnostic methods and test kits to be used in a clinical setting for identifying a subject at risk of folate-sensitive abnormalities or disorders as ... 06/15/06 - 20060127954 - N-11 truncated amyloid-beta monoclonal antibodies, compositions, methods and uses This invention relates to antibodies, including specified portions or variants, specific for at least the human Amyloid-beta 11 N-terminal site, i.e. Aβ11-x peptides. It further provides methods of making and using said antibodies, including therapeutic formulations, administration and devices. ... 06/15/06 - 20060127953 - Method of diagnosing osteolysis Methods for detecting osteolysis are described. The diagnostic method involves detecting the presence of regulatory T cells in a sample from a patient. ... 06/08/06 - 20060121537 - Cellular immunity test with peptides fixed on a solid support The invention concerns a method for detecting cellular immunity (with respect to an antigen), using a solid support whereon is fixed an assortment of peptides constituting T cell epitopes of the antigen to be tested, kits for implementing said method. ... 05/25/06 - 20060110778 - High-throughput screen for identifying selective persistent sodium channels channel blockers A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method provide Na+ depletion/repletion methods for identifying a selective blocker of a ... 05/18/06 - 20060105399 - Materials and procedures for the purification of cells The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can be used to remove stem cells from biological fluids. ... 05/18/06 - 20060105398 - Methods of identifying compounds that modulate igg mediated mast cell activation The present invention relates to methods for identifying compounds capable of modulating Fcg receptor signaling pathway in mast and/or basophil cells. The invention further relates to methods for identifying compounds for use as therapeutic agents in the treatment of disorders related to activation of Fcg receptor signaling cascade. ... 05/11/06 - 20060099653 - Microscopic precision construction of tissue array block related application data This present invention covers novel means, devices and instruments for production of a tissue array block that is further sectioned into duplicates of tissue arrays. An integral microscope is incorporated into the instrument for viewing and examining a stained reference slide and selecting donor tissue core region(s) from the reference ... 05/11/06 - 20060099652 - Il 13 receptor alpha 2 antibody and methods of use The invention provides an antibody directed against an IL13 receptor alpha 2 (IL13-Rα2) and methods of using the antibody to detect and localize IL13-Rα2, to diagnose a disease characterized by expression of IL13-Rα2, and to kill a cell that expresses an IL13-Rα2. ... 05/11/06 - 20060099651 - Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided. ... 05/04/06 - 20060094064 - Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's ... 04/27/06 - 20060088891 - Method of evaluating myelosuppressive state The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective ... 04/27/06 - 20060088890 - Identification and isolation of somatic stem cells and uses thereof The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic stem cells, mesenchymal stem cells and keratinocyte stem cells. The invention also provides for methods of isolation and uses of the stem cells. Derived from the methods of the ... 04/20/06 - 20060084121 - Ox2 receptor homologs Nucleic acids encoding mammalian, e.g., primate, receptors, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described. ... 04/20/06 - 20060084120 - Methods and compositions for modulating hepatocyte growth factor activation The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin. ... 04/20/06 - 20060084119 - Method of screening transporter inhibitor Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range ... 04/13/06 - 20060078947 - Methods and compositions for treating hematological disorders using 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 284 The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, ... 04/13/06 - 20060078946 - Method for manufacturing antigen-specific antibody-producing hybridomas employing a single antigen-specific b lymphocyte and method for manufacturing monoclonal antibody A method for producing a monoclonal antibody and antigen-specific antibody-producing hybridomas using a single antigen-specific B lymphocyte is provided. The method for producing antigen-specific antibody-producing hybridomas comprises selecting a single B lymphocyte reacting specifically with a certain antigen, an “antigen-specific B lymphocyte”, culturing the antigen-specific B lymphocyte selected, and fusing ... 04/06/06 - 20060073523 - Detecting cell membrane protein endocytosis Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds are tested for their effect on endocytosis by complexing the reagent ... 03/30/06 - 20060068447 - Directed assembly of functional heterostructures The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation ... 03/30/06 - 20060068446 - Methods A method for identifying a compound for modulating the immune response in a first type of mammal to a super-antigen, comprising the steps of 5 (7) providing a cell expressing a MHC Class II molecule derivable at least in part from the first type, or cells comprising such a cell ... 03/23/06 - 20060063209 - Engineered antibody fragment that irreversibly binds an antigen The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional ... 03/23/06 - 20060063208 - Drg11-responsive (dragon) gene and uses thereof This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-β signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy. ... 03/16/06 - 20060057646 - Diagnosis of alzheimer's disease A method of diagnosis of Alzheimer's disease comprising the steps of obtaining a sample selected from of a group of samples consisting of body fluid samples and tissue homogenate samples from a patient; of exposing the sample to an antibody directed against Amyloid-beta (Aβ) peptides; of separating a fraction of ... 03/16/06 - 20060057645 - Novel genes The object of the present invention is to detect and select insulin-producing cells capable of proliferating, and further to differentiate/proliferate insulin-producing cells and precursory thereof, or cells related thereto. The present invention was made by finding three species of novel genes by detecting genes specifically expressed in pancreases of PHHI ... 03/09/06 - 20060051815 - Methods of treating smooth muscle cell disorders The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders. ... 03/02/06 - 20060046272 - Whole blood preparation for cytometric analysis of cell signaling pathways This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transient activation states of the epitopes. The method provided by the ... 02/23/06 - 20060040329 - Cxcl10-based diagnosis and treatment of respiratory illnesses Elevated blood levels of the chemokine CXCL10 polypeptide are associated with respiratory illnesses (e.g. SARS, influenza and community-acquired pneumonia) and are useful in diagnosis of patients. Methods are provided for diagnosis and treatment of patients suffering from respiratory illnesses. Methods are provided for identifying inhibitors of the CXCL10:CXCR3 axis, for ... 02/16/06 - 20060035287 - Ileitis diagnostic assay Improved immunoassays for the protection of antibodies against Lawsonia intracellularis are provided which permit rapid, easy detection of low concentrations of anti-Lawsonia antibodies in animal-derived specimens. The preferred assay is an ELISA assay employing an antigenic extract of L. intracellularis lipopolysaccharide. ... 02/16/06 - 20060035286 - Monitor protein for measuring processing of protein A monitor protein for measuring processing of a protein comprising a processing region which contains an amino acid residue or an amino acid residue sequence to be processed and a secretory chimeric protein which originates in the stereostructure of a protein containing at least a processing region formed by the ... 02/16/06 - 20060035285 - Method for identifying modulators of human orexin-2 receptor The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of ... 02/09/06 - 20060029985 - Diagnostic compositions containing an antibody to a beta-arrestin, methods utilizing the same and kits containing the same The invention provides a diagnostic composition for detecting an affective disorder comprising an antibody selected from the group consisting of an antibody to a beta-arrestin, an antibody to a G-protein coupled receptor kinase and combinations thereof as the active detecting agent therein. ... 02/09/06 - 20060029984 - Psp94 diagnostic reagents and assays In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have shown utility as evaluation or prognosis of prostate cancer. Diagnostic assays, methods, and kits for ... 02/09/06 - 20060029983 - Methods of screening compounds for grk6 modulating activity The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. ... 02/02/06 - 20060024761 - Protein biopolymer markers predictive of alzheimer's disease The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 02/02/06 - 20060024760 - Human brain carboxypeptidase b A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene are useful in, for example, preventing, treating, examining, and diagnosing Alzheimer's disease, and such. ... 02/02/06 - 20060024759 - Complex of a chaperone with beta-amyloid and methods employing this complex A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample ... 02/02/06 - 20060024758 - Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs The present invention is directed to methods for the identification and uses of a receptors that interact with anti-inflammatory compounds derived from eicosapentaenoic acid (EPA). The receptors are of the G-protein coupled receptor (GPCR) family, and are useful to screen candidate substances for anti-inflammatory activity, especially substances that are analogs ... 02/02/06 - 20060024757 - Detection of oncofetal fibronectin for selection of concepti Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health ... 02/02/06 - 20060024756 - Methods and algorithms for cell enumeration in low-cost cytometer The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity of the instruments prevents wider ... 01/26/06 - 20060019318 - Conformational and topological protein regulation Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the ... 01/26/06 - 20060019317 - Assay systems and methods for detecting molecules that interact with membrane channels The invention provides an assay system for detecting a molecule that interacts with a membrane channel, the assay system including cell membranes including one or more membrane channels; support bodies including scintillant and a coupling agent that associates with the cell membrane; a ligand that is selected to bind the ... 01/19/06 - 20060014219 - Method for measuring ion channel activity The present invention discloses a human embryo kidney cell or cell line transfected with a GABA-gated chloride channel derived from an insect of the order of Lepidoptera, Diptera, Coleoptera, Homoptera, Acarina, Thysanaptera, Heteroptera, Hymenoptera or Isoptera and its use in a one-pot, high-throughput method for the measurement of the change ... 01/19/06 - 20060014218 - Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 1 (npff1) The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological ... 01/12/06 - 20060008855 - Promiscuous g-protein compositions and their use Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated ... 01/12/06 - 20060008854 - Method of determining time of death A method of determining time of death is disclosed. Cardiac troponin I (cTnI) is the most specific marker for the determination of myocardial infarction (MI). Cardiac troponin I has a distinctive temporal degradation profile after death, which is key to its use as a time of death marker in forensic ... 01/12/06 - 20060008853 - Monoclonal antibodies directed against the microtubule-associated protein tau and method of detecting the same A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein can be obtained from a brain homogenate, itslf isolated from the cerebral cortex of a patient having Alzheimer's disease. Further, a method of detecting the ... 01/05/06 - 20060003388 - Sensitive intracellular calcium assay A sensitive intracellular calcium assay is disclosed comprising conveniently a reagent comprised of a dye precursor capable of entering cells and being hydrolyzed to a dye, whereby the dye complexes with calcium in said cells and provides a luminescent signal, an antibody specific for the dye and conjugated with a ... 01/05/06 - 20060003387 - Cell display libraries Eukaryotic cell display libraries for use in panning processes comprising expressed biomolecules for specific and selective binding and enrichment to solid material surfaces including, for example, metal, magnetic, and semiconducting surfaces. Display can be regulated. Peptide and protein display on yeast cells are preferred. Solid materials can be fabricated in ... 12/29/05 - 20050287606 - T1 receptor-like ligand i The present invention concerns a novel T1R-like ligand I protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand I protein. T1R-like ligand I polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. ... 12/29/05 - 20050287605 - Caspase 3 inhibitors The invention is intended to develop a drug capable of directly or indirectly inhibiting the activation of caspase. Specifically, the invention provides a caspase 3 inhibitor comprising a protein comprising the same or substantially the same amino acid sequence as that represented by SEQ ID NO: 1, 2, 3 or ... 12/29/05 - 20050287604 - Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell-maternal antibody complexes are identified and isolated using labelled agents that bind to the maternal antibodies. The present ... 12/29/05 - 20050287603 - Modulation of bone development Methods and compositions for modulating bone development are described. ... 12/29/05 - 20050287602 - Method of identifying transmembrane protein-interacting compounds A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerise. ... 12/22/05 - 20050282234 - Real time method of detecting acute inflammatory conditions This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this activity. This disclosure presents the surprising discovery that levels of complement pathway components ... 12/22/05 - 20050282233 - Multivalent antibody materials and methods for vegf/pdgf family of growth factors The present invention relates to materials and methods for modulating angiogenesis. The compositions of the invention provide antibody substances specific for two or more PDGF/VEGF family members, which are useful for modulating angiogenesis and lymphangiogenesis in a subject. ... 12/22/05 - 20050282232 - Compositions and methods for modulating c-rel-dependent cytokine production The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of ... 12/15/05 - 20050277158 - Method and kit for donor specific complement-fixing antibodies crossmatch Provided is a flow cytometry method and kit composition for semi-quantitatively determining complement fixing antibodies (CFAbs). The said antigen specific CFAbs in the sample will react with the antigens on the solid carriers or the surfaces of target cells as well as the labeled complement or labeled anti-complement antibody at ... 12/15/05 - 20050277157 - Organ transplant rejection and associated conditions The application discloses markers associated with organ transplant rejection and associated conditions, and in particular provides materials and methods for the diagnosis, prognosis or treatment of chronic rejection of transplanted organ such as heart and kidney. Examples of the markers include ribosomal protein L7, β-transducin, 1-TRAF (also known as TANK) ... 12/08/05 - 20050272099 - Androgen receptor complex-associated protein The invention relates to new proteins that bind to and aide the transactivation activity of androgen receptors, and nucleic acids encoding them. ... 12/08/05 - 20050272098 - Quantitation of endothelial microparticles The present invention provides a method for determining the presence of atherosclerosis in a patient and a method for measuring atherosclerotic burden in a patient diagnosed with atherosclerosis. The methods use a two-color flow cytometric technique to quantitate the absolute number of endothelial microparticles (EMPs) in vitro using a known ... 12/08/05 - 20050272097 - Methods and compositions for detecting and treating autoimmune diseases Diseases caused by or affected by specific antibodies and/or T lymphocytes that complex with self-molecules in a subject are detected by identifying antigen specific antibodies and/or effector T lymphocytes against the antigen, in a biological fluid of an affected subject. This identification opens up treatment possibilities, for example, by desensitization. ... 12/08/05 - 20050272096 - Amphiphilic mediated sample preparation for micro-flow cytometry A flow cytometer includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the oil phase and the water phase, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit ... 12/01/05 - 20050266504 - Methods for diagnosing and treating alzheimers disease and parkinson's disease The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or treatment of Alzheimer's disease and Parkinson's disease, and a ... 12/01/05 - 20050266503 - Simultaneous assay of target and target-drug binding Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. ... 12/01/05 - 20050266502 - Methods, compositions and compound assays for inhibiting amyloid-beta protein production A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta ... 12/01/05 - 20050266501 - Reagent for detecting risk factor of alzheimer's disease, detection kit therefor and method of detecting risk factor of alzheimer's disease using the same A reagent for detecting a risk factor of Alzheimer's disease which contain, as the active ingredients, an antibody specific to apolipoprotein E4 and an antibody against all of apolipoprotein E2, apolipoprotein E3 and apolipoprotein E4; a detection method; and a detection kit. Thus, apolipoprotein E4 genotype can be economically and ... 11/24/05 - 20050260688 - Methods and compositions for hair growth Methods and compositions for identifying and isolating dermal papilla cells are described. DP cells can be identified based on corin expression. Isolated DP cells can be used, e.g., to modulate hair growth. ... 11/24/05 - 20050260687 - Dna encoding mammalian neuropeptide ff (npff) receptors and uses thereof This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences ... 11/17/05 - 20050255531 - Process for identifying modulators of g-protein-coupled receptors The invention relates to a widely applicable process for identifying chemical compounds, which modulate G-protein-coupled receptors, by means of novel hybrid G-proteins with broad receptor specificity and very high expression and also to chemical compounds which can be identified by such a process. ... 11/17/05 - 20050255530 - Identification and isolation of pluripotency determining factors Transcription factors associated with maintenance of pluripotency, Oct-4 and Nanog, are expressed in bovine and/or caprine pre-implantation embryos and isolated. Oct-4 protein and mRNA are expressed in both the inner cell mass and trophectoderm of expanded goat blastocysts. Oct-4 may play a role in trophectoderm proliferation and prevention of premature ... 11/17/05 - 20050255529 - Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor The present invention is directed to novel uses of a polynucleotide sequence of a novel G-Protein Coupled Receptor 5HT6. The invention also provides the human 5-HT6 receptor as being associated with hematological disorders, pain diseases, respiratory diseases, genito-urological disorders, cardio vascular diseases and cancer. The invention also provides assays for ... 11/10/05 - 20050250161 - Generation of antigen specific t suppressor cells for treatment of rejection This invention provides a method of generating antigen specific allospecific human-suppressor CD8+CD28− T cells. This invention also provides a method of generating xenospecific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28− T cells. Methods of treatment for, reduction of ... 11/03/05 - 20050244899 - Laminin receptor 1 precursor protein (37lrp) epitope delineated by an hepatocellular carcinoma specific antibody This invention relates to the diagnosis and treatment of cancerous diseases, particularly to such diagnosis and treatment which revolves around the ability of the 5LAC-23 monoclonal antibody (or antigenic binding fragments derived therefrom) to bind with the Laminin Receptor 1 Precursor Protein 37LRP; and most particularly to diagnosis and treatment ... 11/03/05 - 20050244898 - Large-area two-dimensional non-adhesive cell arrays for sensing and cell-sorting applications One aspect of the present invention relates to an array of non-adhesive cells, comprising a polymeric substrate, an array of a graft copolymer bound to the polymeric substrate, an antibody bound to the polymeric substrate in an area of the polymeric substrate not covered by the graft copolymer, and a ... 11/03/05 - 20050244897 - Endothelial cells as diagnostic instrument in cardiovascular diseases The invention relates to a method for the immunocytological determination of apoptotic endothelial cells and/or endothelial precursor cells in samples such as, for example, peripheral blood, by means of, for example, throughflow cytometry or by means of a solid-phase immunoassay, as a diagnostic instrument in patients in whom a cardiovascular ... 11/03/05 - 20050244896 - Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 2 (npff2) The invention provides a human NPFF2 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological ... 11/03/05 - 20050244895 - Diagnosis of demyelinating or spongiform disease A method for detecting demyelinating disease or spongiform encephalopathy in verterbrates comprising testing a biological sample obtained from the vertebrate for antibodies capable of binding to both Acinetobacter antigens and to prion antigens. This test can be combined with previously described tests involving measurement of antibodies capable of binding to ... 11/03/05 - 20050244894 - Modulators of paraptosis and related methods The invention is directed to a method of identifying a compound that modulates SP-induced paraptosis by (a) contacting a population of cells with an effective amount of substance P to induce SP-induced paraptosis; (b) contacting a first sub-population of the cells with a test-compound, and a second sub-population of the ... 10/27/05 - 20050239143 - Immunocapture-based measurements of mammalian pyruvate dehydrogenase complex The present invention is based on the discovery that an antibody specific for PDH complex can be used to immunoprecitate PDH complex from the patient sample in an active state. Therefore the anti-PDH complex specific antibody can be used to determine the amount of and/or active state of PDH in ... 10/20/05 - 20050233388 - Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system The ability of mononuclear leukocytes to respond to standard stimuli is measured based on the expression of activation antigens on mononuclear cell subclasses. In a preferred embodiment, a sample of mononuclear leukocytes is cultured for up to 24 hours with a standard stimulus known to activate such cells. After culturing, ... 10/20/05 - 20050233387 - Assay method A new method for assaying the ability of a compound to block the binding of an α4 integrin to a binding partner thereof provides a useful screening tool. ... 10/20/05 - 20050233386 - Human hematopoietic growth regulatory gene and uses The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to a human hiwi gene. Also provided are recombinant expression constructs ... 10/20/05 - 20050233385 - Method for detecting transferrin receptor-like proteins The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of ... 10/20/05 - 20050233384 - Detection of antibodies to gangliosides using solid-phase reactants coated with carbonyl groups Methods of detecting antibodies to one or more ganglioside(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached thereon, and the ganglioside(s) of interest linked to the solid-phase reactant by an amide bond between an amino group of the ganglioside of interest ... 10/20/05 - 20050233383 - Human olfactory receptors and genes encoding same The invention relates to cloned human olfactory receptors and the use thereof for identifying compounds that modulate olfaction. ... 10/13/05 - 20050227298 - Method for antigen retrieval and submersion fluid compositions for use therein The present invention relates to a method for retrieving the antigenicity of a formaldehyde-fixed sample for immunological staining and to compositions used in such a method. A method of the invention comprises submerging a sample in a submersion fluid composition comprising an osmotically active compound and heating the said submerged ... 10/13/05 - 20050227297 - Method for immunohistochemical detection of collagen in a tissue sample Pretreating a tissue sample with an effective amount of collagenase results in increased immunodetection of collagen and enhanced preservation of tissue morphology. Such an improved method for immunodetection of collagen can be used in immunohistochemical studies of formalin-fixed, paraffin-embedded tissue sections. ... 10/13/05 - 20050227296 - Method for indentifying integrin antagonists The invention features methods for identifying compounds capable of inhibiting the binding of a selected integrin to a selected ligand which naturally binds the selected integrin. ... 10/13/05 - 20050227295 - Constitutively activated human g protein coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity. ... 10/06/05 - 20050221394 - Ion channel The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also ... 10/06/05 - 20050221393 - Method of increasing product expression through solute stress A method of determining the optimal level of product expression and cell growth of animal cell culture is described. The method generally comprises culturing cells under conditions of solute stress, that is, under conditions whereby optimal cell growth or growth rate is decreased yet levels of product expression are increased. ... 10/06/05 - 20050221392 - Detection and isolation of cell populations from muscle using antibodies to fa1/dlk1 The present invention relates to the use of antibodies recognizing Fetal Antigen-1 (FA1/dlk1) for the detection and isolation of cell populations in mammalian muscle. In one embodiment, myogenic progenitor cells are detected in developing, diseased or regenerating muscle. In another embodiment, muscle stem and progenitor myogenic progenitor cells are isolated ... 10/06/05 - 20050221391 - Reagents and methods for identification of binding agents A method for identifying a desired binding agent that interferes with the interaction between a protein, protein fragment, polypeptide or a peptide and a binding surrogate. The method comprises combining the protein, protein fragment, polypeptide or peptide, the binding surrogate and a binding agent. Detecting a decrease in the interaction ... 09/29/05 - 20050214874 - Diagnosis and treatment of early pre-type-1 diabetes utilizing glial fibrillary acidic protein This invention relates to the treatment and diagnosis of Type-1 Diabetes (T1D); particularly to the use of glial fibrillary acidic protein (GFAP) as a mediator of the disease; and most particularly to GFAP binding proteins useful for prediabetes screening and/or staging. ... 09/29/05 - 20050214873 - Antibody for isolating and/or identifying mesenchymal stem cells, and method for isolating and/or identifying mesenchymal stem cells The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which ... 09/29/05 - 20050214872 - Antibodies isolating and/or identifying neuronal stem cells and method for isolating and/or identifying neuronal progenitor cells The present invention relates to monoclonal antibodies or fragments thereof for isolating and/or identifying neural progenitor cells. The antibodies or fragments thereof bind to an identical antigen as an antibody which is produced by the hybridoma cell lines W4A5, W8C3 and 57D2 deposited on Aug. 14, 2002, at the under ... 09/29/05 - 20050214871 - Methods for using the cd163 pathway for modulating an immune response The invention relates to the field of immunology, gene therapy, and medicine. More specifically, the invention relates to the identification of a molecule capable of interacting with a soluble and/or cell-bound form of CD163 and, as a result of the interaction, an immune response is either instigated or suppressed in ... 09/29/05 - 20050214870 - Assay The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound ... 09/22/05 - 20050208597 - Microarray analysis of post-translational modifications Methods and kits are provided for a multiplexed reverse phase protein (RPP) microarray platform, which is utilized for simultaneous monitoring of cellular components following exposure to an agent or agents of interest. The microarray comprises cell lysates or fractions thereof. The array is probed with a specific binding agent or ... 09/22/05 - 20050208596 - Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Additionally, the invention relates to methods for producing and identifying inhibitors of an anti-platelet autoantibody binding with a platelet, or a ... 09/22/05 - 20050208595 - High throughput assay systems and methods for identifying agents that alter expression of cellular proteins Disclosed are high throughput assay systems and methods for identifying agents that alter the level of expression of proteins in mammalian cells, particularly integral membrane proteins. ... 09/22/05 - 20050208594 - Diagnostics method Method of diagnosing in an individual recent exposure to an agent which is a pathogen, vaccine or any other moiety which induces a cellular response, said method comprising determining in vitro whether the T cells of the individual recognise a protein from said agent having a length of at least ... 09/15/05 - 20050202516 - Methods and compositions for neural progenitor cells The invention relates to methods and compositions for the isolation of neural progenitor cells. ... 09/15/05 - 20050202515 - Functional method for generating or screening for ligands which modulate steroid hormone receptors This application presents the discovery that the Vitamin D3 receptor (VDR), a member of the nuclear hormone ligand-activated receptor superfamily, interacts with a MNAR, a scaffolding protein. This interaction results in the formation of a ternary complex between VDR, MNAR, and the Src or PI3 kinase families of tyrosine kinases ... 09/15/05 - 20050202514 - Competitively stable target cell populations isolated from selectively expanded target cell populations The invention provides a product and methods of isolating a competitive population from a selective expansion of a predetermined target population of cells, including, inter-alia, the step of (a) reintroducing a selectively amplified population into a starting sample of cells into a growth medium. The invention provides for a competitively ... 09/15/05 - 20050202513 - Method of judging cardiotoxicity of anthracycline-type anticancer chemical therapeutic by detecting human h-fabp and reagent therefor The present invention provides a method of determining toxicity to the heart of an anthracycline-type anticancer chemotherapeutic agent such as adriamycin etc., which comprises detecting human H-FABP (Human Heart-type Fatty Acid-Binding Protein) in the blood separated from human, a reagent therefor, a kit therefor and the like. ... 09/01/05 - 20050191709 - Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue A method for determining the relative benefits of products which affect animal epithelial tissue is provided. Also provided is a method for evaluating quantitative changes on one or more affected surfaces of epithelial tissue of a subject caused by a test product. ... 08/25/05 - 20050186640 - Novel anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBPl2.6 in a subject; to prevent exercise-induced sudden cardiac death ... 08/25/05 - 20050186639 - Gene originating in human chondrocyte This invention provides a gene specifically expressed in differentiated human chrondrocytes. By culturing the chrondrocytes in the presence of dibutyryl cAMP, the chrondrocytes are cultured in a differentiated state and any gene is searched for which has a distinction in expression between differentiated chrondrocytes and dedifferentiated chrondrocytes. This allows the ... 08/18/05 - 20050181461 - Assays for sensory modulators using a sensory cell specific g-protein alpha subunit The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory ... 08/18/05 - 20050181460 - Antibody specific to central nervous system tau protein The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connective portion between the amino acid sequence encoded by Exon 4 ... 08/18/05 - 20050181459 - Method for mapping and eliminating t cell epitopes The invention provides methods for the identification of immunogenic regions within the amino acid residue sequence of a polypeptide, such as a therapeutic protein or a fragment thereof. The method comprises the steps of: (i) culturing, in vitro, an aliquot of peripheral blood monocyte cells (PBMC) isolated from a donor ... 08/18/05 - 20050181458 - Hpv cd8+ t-cell epitopes The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention ... 08/18/05 - 20050181457 - Fcyriii signaling inhibitor assay The present invention provides an assay and its use for identifying agents that inhibit the FcγRIII signaling. ... 08/11/05 - 20050176069 - G protein-coupled receptor-like receptors and modulators thereof The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a ... 08/11/05 - 20050176068 - Direct cell target analysis Disclosed herein are Direct Cell Target Analysis (“DCTA”) molecules and Direct Cell Target (“DCT”) methods for directly targeting and acting upon biomolecules. These methods and molecules can be used with specific cells within complex, heterogeneous tissue such that target biomolecules can be procured for subsequent analysis or directly analyzed without ... 08/04/05 - 20050170440 - Treatment and diagnosis of insulin-resistant states Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing ... 08/04/05 - 20050170439 - Methods for detecting receptor complexes comprising pi3k The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more ... 08/04/05 - 20050170438 - Methods for detecting receptor complexes comprising pdgfr The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more ... 08/04/05 - 20050170437 - Methods and compositions relating to modulating amyloid precursor protein cleavage The invention relates in part assays for identifying and testing compounds that modulate cleavage of amyloid precursor protein (APP). In addition, the invention relates to novel cleavage products of APP. The invention additionally relates to methods and assays for identifying compounds that inhibit acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity. The methods ... 08/04/05 - 20050170436 - Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that ... 08/04/05 - 20050170435 - Biosensor and use thereof to identify therapeutic drug molecules and molecules binding orphan receptors A G protein biosensor cell comprises G protein beta, gamma or both beta and gamma subunits tagged with a fluorescent protein(s) expressed in living intact functional cells. The subcellular location of the fluorescent protein tagged beta, gamma or both beta and gamma subunits is strongly responsive to the activation state ... 08/04/05 - 20050170434 - Modulators of lymphocyte activation, mkk3b compositions and methods of use The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the ... 08/04/05 - 20050170433 - Three dimensional coordinates of melanin-concentrating hormone receptors Three-dimensional coordinates of melanin-concentrating hormone receptors are useful in computer aided drug design. ... 07/28/05 - 20050164310 - Assays for sensory modulators using a sensory cell specific g-protein alpha subunit The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory ... 07/28/05 - 20050164309 - Composition and method for modulating somatolactogenic function A human prolactin-binding protein and compositions and methods using this protein are provided. ... 07/28/05 - 20050164308 - Beta-lactamase cd4+ t-cell epitopes The present invention provides beta-lactamase CD4+ T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental beta-lactamase. The present invention further provides DNA molecules that encode novel beta-lactamase variants, host cells comprising DNA encoding novel beta-lactamase variants, as well as methods for making ... 07/28/05 - 20050164307 - Methods of screening agonistic antibody Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can ... 07/28/05 - 20050164306 - Methods for screening for a compound useful in the treatment or prevention of lymphocytic disorders, for inhibiting lymphocite activity and preventing or treating lymphocytic disorders A method of screening for a compound useful in the treatment of a disease or condition characterized by an immune cells disorder, wherein said cell expresses NTPDases, said method comprising the steps of contacting a candidate compound with ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), wherein the candidate compound is selected if the ... 07/28/05 - 20050164305 - Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) The invention provides a human FPRL1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD, asthma, genito-urological disorders and inflammation diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of ... 07/21/05 - 20050158803 - Antibodies specific for native prpsc Antibodies are disclosed which specifically bind to native PrPSc in situ. Preferred antibodies bind only to the native PrPSc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrPSc. Preferred antibodies of the invention are (1) produced by ... 07/21/05 - 20050158802 - Ubch8 ubiquitin e2 enzyme is also the e2 enzyme for isg15, an interferon alpha/beta induced ubiquitin-like protein The present invention relates to compositions and methods for the modulation of both ubiquitin and ubiquitin-like protein mediated modification and degradation of target proteins that includes the steps of contacting the compound with an Ubiquitin-like protein E2 enzyme and an E1 enzyme containing an ISG15 protein and an E1 containing ... 07/21/05 - 20050158801 - Systems and methods for characterizing kidney diseases The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the ... 07/21/05 - 20050158800 - G-coupled receptor showing selective affinity for atp The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention ... 07/21/05 - 20050158799 - Trif-related adaptor molecule (tram) and uses thereof A Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-β (TRIF)-related adaptor molecule (TRAM) has been identified. TRAM acts specifically in the TLR4 signaling pathway. The invention includes compounds useful for modulating TLR signaling by modulating the effects of TRAM. ... 07/14/05 - 20050153370 - Method of enhancing signal detection of cell-wall components of cells The invention relates to methods of enhancing signal detection of components of cell walls, wherein the methods involve lysing cells to form cell-wall fragments and analyzing the cell-wall fragments. ... 07/14/05 - 20050153369 - Mimotopes and anti-mimotopes of human platelet glycoprotein ib/ix The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the ... 07/14/05 - 20050153368 - Method of identifying chemical agents which stimulate odorant receptors of sensory neurons The present invention provides methods for identifying agents which modulate mosquito odorant receptors. The methods disclosed herein use genetic material of mosquito odorant receptors to express those receptors in a foreign host system in which the endogenous receptors have been removed. ... 07/14/05 - 20050153367 - Method of detecting immune response Transformed immortalized immune cell lines have traditionally been used as effectors for drug screening. Such programs may overlook an important principle: the initiation of a wide spectrum of immunomodulatory responses requires the collateral interactions of macrophage, B cells and T cells. This invention provides methods of detecting immune response of ... 07/07/05 - 20050148032 - Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, ... 07/07/05 - 20050148031 - Catalytic efficiency and/or specificity of non-native substrates of enzymes A method of introducing a fluorescent label into a cell, comprising: exposing a reporter to the cell, wherein the reporter comprises: a peptide substrate for an enzyme, a docking domain for the enzyme, attached to the peptide substrate, a membrane traversing moiety, and the label. ... 06/30/05 - 20050142619 - Antibodies to mammalian langerhans cell antigen and their uses Purified mammalian DC cell surface protein, designated Langerin, nucleic acids encoding Langerin, and antibodies which specifically bind Langerin. ... 06/30/05 - 20050142618 - Method for diagnosing diseases based on levels of anti-glycan antibodies Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid Syndrome (APS) by measuring levels of antibodies to glycans in a biological sample. ... 06/30/05 - 20050142617 - High bone mass gene of 11q13.3 The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present ... 06/30/05 - 20050142616 - Diagnostic test for neuropsychiatric systemic lupus erythematosus This invention provides methods for assessing the likelihood that a patient is suffering neuropsychiatric systemic lupus erythematosus by detecting autoantibodies in a sample from the patient. This invention also provides diagnostic kits for the same. ... 06/23/05 - 20050136490 - Diagnostic method for determining the susceptibility to delivery and reagent kit for use thereof The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay ... 06/23/05 - 20050136489 - Biomarkers for liver diseases and method for using the same Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or ... 06/23/05 - 20050136488 - Cellular membrane protein assay Methods and compositions are provided for determining cell membrane protein populations in the cell membrane of a cell and changes in the population due to changes in the environment or status of the cell. The methods employ a cell having a fusion construct of the cell membrane protein linked to ... 06/23/05 - 20050136487 - Transmissible spongiform encephalopathy detection in cervids, sheep and goats A method for diagnosing scrapie in sheep or goats and chronic wasting disease in deer or elk is provided including detecting spectral changes between disease-positive samples and disease-negative samples providing a calibration model for use in classifying unknown samples as disease-positive or disease-negative. ... 06/23/05 - 20050136486 - Methods for optically encoding an object with upconverting materials and compositions used therein The present invention relates generally to encoding samples. More specifically, it relates to barcodes and compositions involving upconverters and methods including them. In a composition aspect of the invention, a composition comprising two or more lanthanide materials is provided. Each lanthanide material comprises a host, an absorber, and an emitter, ... 06/16/05 - 20050130234 - Method for characterization of abnormal cells It is described a method to detect and phenotype target cells in cell suspensions by using particles coated with antibodies/ligands directed to antigenic determinants/receptors expressed on the target cells, characterized in that several types of particles, each particle coated with different antibody or ligand, are incubated simultaneously or subsequently with ... 06/16/05 - 20050130233 - Methods of diagnosing or treating alzheimer's disease on basis of increased cerebrospinal fluid levels of nerve growth factor A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, involves determining a level, or an activity, or both the level and the activity, of nerve growth factor in a sample taken from cerebrospinal fluid of ... 06/16/05 - 20050130232 - Methods of screening for compounds that modulate hormone receptor activity The present invention provides methods for identifying an effective agent that modulates a biological activity of a nuclear hormone receptor. In a method of the invention, an isolated receptor-containing complex is assayed for an altered modification state as compared to a control modification state. The presence of an altered modification ... 06/16/05 - 20050130231 - Method for analyzing effects of medical agents A method for analyzing the effects of medicinal agents, and more particularly, an ex vivo method of analyzing the effects of medicinal agents on the human immune system is provided. ... 06/09/05 - 20050124007 - Human mesencephalon cell lines and methods of use therefor Conditionally-immortalized human mesencephalon cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including dopaminergic neurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of neurological diseases such as Parkinson's ... 06/09/05 - 20050124006 - Method for diagnosing diseases based on levels of anti-glycan antibodies Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample. ... 06/09/05 - 20050124005 - Use of a labeled ligand having human cd4 specificity for producing a diagnostic used in the analysis of migration and/or distribution patterns of cell populations The invention concerns the use of a labelled ligand having specificity for the human CD4 molecule to produce a diagnostic agent for analysing migration and/or distribution patterns of certain cell populations which comprise CD4-bearing cells in human individuals. In addition the invention concerns a composition which comprises a labelled ligand ... 06/09/05 - 20050124004 - Histamine receptor h3 polynucleotides Novel splice variants of the human H3 histamine receptor are described. The splice variants have deletions of portions of the N-terminal of the wild type H3 receptor. The splice variants are useful in methods for identifying agonists, inverse agonists or antagonists of histamine action at the H3 receptor. ... 06/09/05 - 20050124003 - Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cells by gene transfection and other means for therapeutic applications. ... 06/02/05 - 20050118652 - Rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method The invention provides a genetic screening method for identifying a transfected cell expressing the polypeptide of interest. The methods allows for high throughput screening of recombinant cells for elevated levels of expression of the polypeptide of interest. The invention also provides capture media, formulations and methods of making and using ... 06/02/05 - 20050118651 - Humanized antibodies that recognize beta amyloid peptide The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include antibodies, e.g., humanized antibodies. ... 06/02/05 - 20050118650 - Fourier transform mass spectrometry of complex biological samples The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., ... 06/02/05 - 20050118649 - Method of analyzing organelle-localized protein and materials for analysis A method for analyzing an organelle-localized protein, which enables one to determine whether or not a test protein localizes to an organelle, comprising the steps of: (a) a step of introducing a fusion peptide (a), which comprises one half-peptide of an intein, one half-peptide of a fluorescent protein and an ... 06/02/05 - 20050118648 - Methods and combinations for gene targeting by homologous recombination The invention provides methods and compositions for inserting a DNA sequence in the genome of a cell by homologous recombination. In particular, the method utilizes a selection scheme in which a selection marker gene that encodes a fluorescence protein, such as a green fluorescence protein, is used for selection against ... ### FreshPatents.com Support |