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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding AssayInvolving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087389 - Control system using immune network and control method To provide a new method for autonomously controlling the behavior of a control target device based on a stimulating action and a suppressing action among antibodies in an immune network, an operating unit 3 calculates an antibody concentration ai(t) serving as an index for selecting an antibody module ABi, while ... 04/19/07 - 20070087388 - G protein coupled receptor The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same. ... 04/19/07 - 20070087387 - Method for the early detection of renal disease using proteomics A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins ... 04/19/07 - 20070087386 - Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and ... 04/19/07 - 20070087385 - Spherical and magnetical silicagel carriers having an increase surface for purifying nucleic acids The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to ... 04/19/07 - 20070087384 - Cynomolgus monkey dickkope-4, nucleotides encoding same, and uses thereof The cynomolgus monkey Dickkopf-4 (cDkk-4) protein, isolated nucleic acid molecules which encode the cDkk-4 protein, and recombinant vectors and hosts comprising DNA encoding the cDkk-4 protein are disclosed. Also disclosed are methods for identifying analytes which interfere with the interaction between the cDkk-4 protein and a homologous or heterologous Dkk ... 04/19/07 - 20070087383 - Immunoassay The invention provides a method for detecting a hapten in a sample comprising the steps of: a) providing a sample potentially containing the hapten; b) providing a pre-determined amount of a first moiety, said first moiety being bound to a signaller and separated therefrom by a first linker, which first ... 04/19/07 - 20070087382 - Molecule array and method for producing the same The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid ... 04/19/07 - 20070087381 - Methods for constructing scdb libraries Bispecific diabody libraries can be constructed from scFv libraries efficiently and without troublesome procedures by a single treatment, placing restriction enzyme sites appropriately for antigen-encoding regions. ... 04/19/07 - 20070087380 - Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, ... 04/12/07 - 20070082365 - Protein scaffolds for antibody mimics and other binding proteins Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands. ... 04/12/07 - 20070082364 - Antibody and use thereof The antibody of the present invention, which specifically reacts with a partial peptide at the N-terminal region or the C-terminal region of NPW, which enables to quantify NPW with highly sensitivity and specifically. Moreover, this antibody is useful as an agent for preventing/treating infertility, renal edema, digestive ulcer, gastric hyperacidity, ... 04/12/07 - 20070082363 - Secreted polypeptide species reduced cardiovascular disorders The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and treatment of cardiovascular disorders. ... 04/12/07 - 20070082362 - Modified soluble t cell receptor The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain ... 04/05/07 - 20070077599 - Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith The present invention relates to optical bio-disc systems and related methods and to immobilizing receptor molecules. When a sample is injected into a fluidic circuit, the target agent binds to a capture probe bound in a capture zone. A signal is generated from tags attached to a reporter probe that ... 04/05/07 - 20070077598 - Methods of diagnosis, prognosis and treatment of cardiovascular disease The invention provides methods for diagnosis or prognosis of cardiovascular disease involving the detection of an elevated amount of MIC-1 in a test body sample. The invention also provides methods for treatment of cardiovascular disease and other chronic inflammatory disease. ... 04/05/07 - 20070077597 - Method for identifying modulators of g protein coupled receptor signaling This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these ... 04/05/07 - 20070077596 - Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, ... 04/05/07 - 20070077595 - Miniaturized spectometer using optical waveguide and integrated raman system on-chip One embodiment relates to an analyzer having an interferometer, a detector and a microprocessor, wherein the analyzer does not contain a spectrometer having a dispersive grating, the interferometer is to create a phase shift in an original spectrum of electromagnetic radiation emitted from a sample and Fourier transform the original ... 04/05/07 - 20070077594 - Electroluminescent device The invention relates to a matrix of electroluminescent organic material having quantum dots embedded therein. Electrodes provide electrons and holes to the matrix forming excitons to be transferred to the quantum dots. The invention provides transfer molecules on the quantum dots facilitating the transfer of excitons from the electroluminescent organic ... 04/05/07 - 20070077593 - Substrate as a ligate carrier Described is a substrate for use as a ligate carrier in a method for detecting ligate-ligand association events, having test sites 24 disposed on the substrate and having ligates 26 bound to the surface of the test sites 24, at least two types of test sites 24 being provided, the ... 04/05/07 - 20070077592 - Hemipteran glutamate decarboxylase Novel nucleic acid sequences encoding hemipteran L-glutamate decarboxylases, and the amino acid sequence of such protein are disclosed. Methods of making and using the same are disclosed. ... 03/29/07 - 20070072242 - Immunoassay method and kit to leucomalachite green and malachite green The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with leucomalachite green and malachite green. ... 03/29/07 - 20070072241 - Diagnostic methods for age related macular degeneration Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in ... 03/29/07 - 20070072240 - Method for producing an in vitro expression library The present invention relates to an antibody expression library derived from a patient which has been immunochallenged with one or more foreign antigens associated with a particular disease or foreign agent, wherein said patients have been immunochallenged with the foreign antigens at a time point such that they still contain ... 03/29/07 - 20070072239 - Pharmaceutical compositions and methods of using secreted frizzled related protein Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be ... 03/29/07 - 20070072238 - Wnt-frizzled chimera The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer. ... 03/29/07 - 20070072237 - Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6 The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6 ... 03/29/07 - 20070072236 - Novel type ii na/pi cotransporters and type ii na/pi cotransporter expression regulatory factors The present invention provides novel type IIc Na/Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na/Pi ... 03/29/07 - 20070072235 - Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of ... 03/29/07 - 20070072234 - Protein capable of binding plasticizer The present invention provides a protein having a binding capacity to a plasticizer, which has been conferred with useful properties for measuring, quantifying, or concentrating a plasticizer, such as high sensitivity, low cross-reactivity, high tolerance for interferents, and high tolerance for solvents. Specifically, the present invention provides a modified protein ... 03/22/07 - 20070065880 - Compositions and methods relating to elutable carbohydrate-binding proteins Compositions and methods are provided for creating and identifying mutant carbohydrate-binding proteins that reversibly bind to carbohydrate substrates under conditions where the native protein remains bound. Examples of modified chitin-binding domains are provided which can be eluted from chitin in the presence of a reducing agent or at a pH ... 03/22/07 - 20070065879 - Marker for inflammatory conditions Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. ... 03/22/07 - 20070065878 - Cellular libraries of peptide sequences (clips) and methods of using the same The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. ... 03/22/07 - 20070065877 - Microarray having a base cleavable succinate linker There is disclosed a microarray having base cleavable succinate linkers. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Amino moieties are attached to the reactive hydroxyl groups. Preferably the ... 03/15/07 - 20070059772 - Phosphorylated glyoxalase i and its use The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate MG-modification of proteins (AGE formation) and consequent cell death, especially upon stress such as oxidative stress, or upon TNF treatment. ... 03/15/07 - 20070059771 - Protein o-sulfonation Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference ... 03/15/07 - 20070059770 - Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... 03/15/07 - 20070059769 - High throughput glycan microarrays The invention provides arrays of glycans for detecting entities that bind to glycans. In some embodiments, the arrays can be used to detect disease, blood types, antibodies, bacterial or viral infection, cancer, and the like. The invention also provides methods and kits for such detection. In another embodiment, the invention ... 03/15/07 - 20070059768 - Broad host range vectors for shotgun and expression library cloning in gram negative bacteria The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments, ... 03/15/07 - 20070059767 - Method of identifying n-terminal probnp The invention relates to a method of identifying N-terminal proBNP in a sample with at least two antibodies that detect different epitopes of the N-terminal proBNP. The method is used to differentiate or classify samples of healthy individuals and samples of patients of NYHA classes I to IV. The invention ... 03/15/07 - 20070059766 - Mixture of binding proteins Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and ... 03/15/07 - 20070059765 - Liposome-based microarray and methods of use thereof This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject ... 03/15/07 - 20070059764 - Electrospray coating of aerosols for labeling and identification A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to ... 03/15/07 - 20070059763 - Cellomics system In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction ... 03/15/07 - 20070059762 - Insulin resistance curative and method of screening the same The present invention provides a screening method for a compound which is highly safe and has a prophylactic or therapeutic effect on diabetes, and a highly safe pharmaceutical composition for the prophylaxis or treatment of diabetes. Specifically, a drug for the prophylaxis or treatment of diabetes, which contains, as an ... 03/15/07 - 20070059761 - Storage and use of colloids The present invention discloses compositions and methods for enabling the longterm storage and/or use of colloid particles without substantial degradation of their performance, for example, by chemical or physical degradation, by particle aggregation, changes in pH and/or relative humidity, changes in salt concentration, and/or by a decrease in the binding ... 03/08/07 - 20070054320 - Cytokine zalpha11 ligand antibodies Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller ... 03/08/07 - 20070054319 - Light-activated cation channel and uses thereof The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention ... 03/08/07 - 20070054318 - Soluble low-density lipoprotein receptor related protein binds directly to alzheimer's amyloid-beta peptide A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-β peptide (Aβ). This binding may be used to detect Aβ or to separate Aβ from the rest of a subject's body. In Alzheimer's disease, it may be used to provide diagnostic results by detecting Aβ, ... 03/08/07 - 20070054317 - Electrochemical affinity biosensor system and methods The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated ... 03/08/07 - 20070054316 - Radical activated cleavage of biologics and microfluidic devices using the same Disclosed is a cleavage method for biological sample characterization using hydroxyl radical activated cleavage in place of traditional enzymatic approaches. The hydroxyl radicals are generated from a semiconductor excited by an energy source. A microfluidic device for the two-dimensional separation of biological samples by hydroxyl radical activated cleavage is also ... 03/08/07 - 20070054315 - Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier. ... 03/01/07 - 20070048800 - Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a ... 03/01/07 - 20070048799 - Cytokine receptor zcytor19 Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor ... 03/01/07 - 20070048798 - Il-21 production in prokaryotic hosts The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, ... 03/01/07 - 20070048797 - Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. Embodiments of the invention provide methods for detecting and ... 03/01/07 - 20070048796 - Biosensor It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting ... 03/01/07 - 20070048795 - Immunoaffinity separation and analysis compositions and methods The present invention provides compositions and methods for immunoaffinity separation of targets from mixtures for enrichment, identification, quantification, and analysis. In particular, disclosed are avian IgY antibodies coupled to solid supports and their methods of use. Further disclosed are systems and methods for fractionating or enrichment a mixture of biological ... 03/01/07 - 20070048794 - Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between ... 03/01/07 - 20070048793 - Compositions and methods for biocatalytic engineering Provided herein are compositions and methods for metabolic pathway engineering. The methods involve combining two or more cells expressing potential pathway proteins extracellularly in the presence of reactants. Also provided are libraries of cells expressing a plurality of pathway components and/or a plurality of variants of a given pathway component ... 03/01/07 - 20070048792 - Preparing biological samples for analysis Methods and devices for preparing a biological sample for analysis are described. The biological sample from an organism has at least macromolecule having a primary structure that naturally degrades after the sample is removed from the organism. The method includes causing the biological sample to adopt a shape to permit ... 03/01/07 - 20070048791 - Crystal structures and models for fc receptors and uses thereof in the design or identification of fc receptor modulator compounds The invention relates to the determination of the three-dimensional structures of Fc receptor proteins, particularly wild-type FcγRIIa, by X-ray crystallography and the use of the structure in identifying and modifying agents for modulating the biological activity of Fc receptors. Also disclosed is a novel dimeric structure for FcγRIIa and novel ... 03/01/07 - 20070048790 - Device for measuring nanometer level pattern-dependent binding reactions The present invention is directed to a device comprising (a) a substrate having a surface and (b) an ordered array of posts over the surface, wherein the posts are capable of binding a protein or small molecule ligand, and wherein the pitch between adjacent posts is less than about 100 ... 03/01/07 - 20070048789 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with, ... 03/01/07 - 20070048788 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with, ... 03/01/07 - 20070048787 - Multi-analyte affinity column A multi-analyte column is disclosed. The column may contain at least one unit of resin having ochratoxin specific affinity and, for each unit of resin having ochratoxin specific affinity, the column further contains about 0.95 to 1.05 units of resin containing antibody having specificity for zearalenone, about 1.9 to 2.1 ... 03/01/07 - 20070048786 - Systems and methods for fractionation of protein mixtures Methods for proteomics analysis, including fractionation or separation of one or more biomolecules that exist in a mixture, for example, using aqueous multi-phase partitioning, which results in isolation of one or more preselected biomolecules, followed by further proteomics analysis. ... 03/01/07 - 20070048785 - Anti-il-13 antibodies and complexes Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed. ... 02/22/07 - 20070042431 - Methods for reducing complexity of a sample using small epitope antibodies The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes. ... 02/22/07 - 20070042430 - Apparatus and method for single-step immunosorbent assay for single and multiple analytes The present invention discloses an apparatus and method for minimizing or eliminating steps in immunosorbent assays by eliminating both the need to attach target molecules to the test well and the need to remove unbound antibodies through rinsing. The single-step immunosorbent assay (SISA) includes the step of mixing the immunologic ... 02/22/07 - 20070042429 - Assay for differentiating alzheimer's and alzheimer's-like disorders The invention relates to an assay for discriminating between Alzheimer's disease (AD) patients, patients with AD-Like disorders that express symptoms like AD, and non-demented age-matched controls (Normal). The method is based on the use of 2-dimensional (2D) gel electrophoresis to separate the complex mixture of proteins found in blood serum, ... 02/22/07 - 20070042428 - Treatment of proliferative disorders Inhibitors of cIAP-1 and methods and compositions for treating proliferative disorders. ... 02/22/07 - 20070042427 - Microfluidic laminar flow detection strip The present invention relates to microfluidic laminar flow detection strip devices and methods for using and making the same. The disclosed devices comprise: a first inlet; a microfluidic channel having a first end and a second end, wherein the first end is fluidly connected to the first inlet; a bellows ... 02/22/07 - 20070042426 - Biomarkers and assays for myocardial infarction Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of myocardial infarction (MI). A multiplexed, mass spectrometric immunoassay (MSIA) ... 02/22/07 - 20070042425 - Diagnostic method for brain damage-related disorders A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, selected from A-FABP, E-FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofilament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Nucleoside diphosphate kinase A, Glutathione ... 02/22/07 - 20070042424 - Method of selectively assaying adiponectin multimers We have discovered a “human adiponectin ELISA kit”, which can specifically measure adiponectin in human blood serum (or blood plasma) or in extracted fluid from lipocytes or culture supernatant fluid. After fractioning human serum by use of gel filtration column, each fraction was measured by the present kit, and as ... 02/22/07 - 20070042423 - Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep-like (rnpep-like) The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological ... 02/15/07 - 20070037218 - Human gene critical to fertility Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using ... 02/15/07 - 20070037217 - Structure-based selection and affinity maturation of antibody library The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a ... 02/15/07 - 20070037216 - Dual expression vector system for antibody expression in bacterial and mammalian cells The present invention provides a dual expression vector, and methods for its use, for the expression and secretion of a full-length polypeptide of interest in eukaryotic cells, and a soluble domain or fragment of the polypeptide in bacteria. When expressed in bacteria, transcription from a bacterial promoter within a first ... 02/15/07 - 20070037215 - Assay particles and methods of use The invention provides assay particles useful, for example, for detecting analytes and binding molecule interactions. One type of assay particle includes a core portion encased by a shell portion, wherein the shell portion comprises an inorganic phosphor that binds selectively to a target molecule. Another type of an assay particle ... 02/15/07 - 20070037214 - Generation and selection of protein library in silico The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein ... 02/15/07 - 20070037213 - Method of analyzing protein and kit for analyzing protein The expression and the phosphorylation level of a target protein are determined without performing complicated operations involving risk; the expression and the phosphorylation level of the target protein are simultaneously determined, by separating and detecting the specific protein from other proteins different from the specific protein, and by specifically detecting ... 02/15/07 - 20070037212 - Human t2r receptors recognizing a class of bitter molecules from coffee The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these ... 02/15/07 - 20070037211 - Peptide antagonists for inhibiting heat shock protein (hsp 16.3) of mycobacterium tuberculosis A process to identify peptide antagonists of Hsp16.3, a chaperon protein necessary for the survival of Mycobacterium tuberculosis in the dormant phase is described. Affinity selection of a 7-mer and a 12-mer random peptide libraries displayed on bacteriophage M13 was performed using recombinant Hsp16.3 as template and two peptide phage ... 02/15/07 - 20070037210 - Cytokine receptor modulators, method of identifying same, and method of modulating cytokine receptors activity with same The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining ... 02/15/07 - 20070037209 - Soluble ectodomain fragments of met and uses thereof The invention relates a fragment derived from the MET ectodomain which the inventors have found is capable, in monomer form, of binding to HGF/SF either in the presence or absence of heparin. The availability of soluble, monomeric forms of the MET receptor enabled studies of its solution properties and HGF/SF ... 02/15/07 - 20070037208 - Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NT-proBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac ischemia. ... 02/15/07 - 20070037207 - Latex reagent for adiponectin analysis and method of adiponectin analysis A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing adiponectin, comprising (1) obtaining a biological liquid possibly containing adiponectin, and (2) bringing the biological liquid, while maintaining the state in which the ... 02/15/07 - 20070037206 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, ... 02/08/07 - 20070031893 - Method for measuring reaction rate coefficient in analysis utilizing total reflection attenuation An object of the present invention is to provide a method for measuring a reaction rate coefficient in an analysis utilizing total reflection attenuation, which is capable of calculating the reaction rate coefficient speedily and accurately. The present invention provides a method for measuring adsorption rate coefficient (Ka) and diffusion ... 02/08/07 - 20070031892 - Novel coumarin-based amino acids for use in enzyme activity and substrate specificity assays The design, synthesis, and utilization of a novel coumarin-based amino acid and its fluorinated derivatives for use in enzyme activity and substrate specificity assays are described. The synthesis is both facile and high-yielding and allows for the production of a highly fluorescent phosphorylated amino acid that can be incorporated into ... 02/08/07 - 20070031891 - Method of analyzing ligand in sample and apparatus for analyzing ligand in sample A sample analyzing method capable of high-precision analysis without being affected by vibration and optical design is provided. In the sample analyzing method, a sample containing a ligand is caused to bind to a receptor that can bind specifically to the ligand, and a change caused by binding of the ... 02/08/07 - 20070031890 - Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also ... 02/01/07 - 20070026464 - Biologically active synthetic thyrotropin and cloned gene for producing same Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described. ... 02/01/07 - 20070026463 - Compositions and methods of mutant nogo-66 domain proteins To facilitate the study of Nogo-66 interaction with its neuronal receptors, and to explore therapeutic opportunities, the present invention provides mutant human Nogo-66 domain-based proteins that do not aggregate during isolation or purification procedures, and methods for using these proteins. Aggregates of Nogo-66 domain containing proteins do not effectively or ... 02/01/07 - 20070026462 - Gas 1 universal leader Disclosed is a polynucleotide molecule comprising a promoter operably linked to a nucleic acid sequence encoding a GAS1 secretion signal peptide, wherein said promoter is not a rhamnose promoter. ... 02/01/07 - 20070026461 - Production of motif-specific and context-independent antibodies using peptide libraries as antigens A method is provided for producing motif-specific, context-independent antibodies that recognize a plurality of peptides or proteins within a genome that contain the same post-translationally modified motif. The method includes the step of immunizing a host with a degenerate peptide library antigen featuring (i) a fixed target motif containing one ... 02/01/07 - 20070026460 - Use of ionic liquids for protein extraction The present invention relates to a method for the extraction of proteins, protein fragments and/or peptides from biological samples, where the extractants employed are ionic liquids of the general formula K+A−, to a kit for the extraction of proteins, protein fragments and/or peptides, and to the use thereof. ... 02/01/07 - 20070026459 - Methods for determination of an analyte The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to ... 02/01/07 - 20070026458 - Assessing insulin resistance using biomarkers The invention encompasses novel biomarkers and methods for assessing insulin resistance in a subject. The novel biomarkers of the invention include various plasma constituent (e.g., insulin, glucose, lactate and/or triglyceride) concentrations. The methods of the invention include measuring various plasma constituent concentrations and calculating a predicted euglycemic hyperinsulinemic clamp glucose ... 02/01/07 - 20070026457 - Screening method The present invention provides a method of screening an agent for the prevention/treatment of cancer. More specifically, the present invention provides a screening method/screening kit for screening a compound or its salt that changes the binding properties of a protein comprising the same or substantially the same amino acid sequence ... 02/01/07 - 20070026456 - Method of biomolecule analysis and method of identifying biomolecule therewith A biomolecule is analyzed with high accuracy. A biomolecule is analyzed with high likelihood. A biomolecule as an analysis subject is modified with a marker binding or adsorbing to only its specific portion (S101). Next, the biomolecule modified with the marker is developed on a base plate (S102). The arrangement ... 02/01/07 - 20070026455 - Method of producing hybridoma and utilization thereof The present invention provides a method of producing an antibody-producing hybridoma, which includes fusing a B cell immunized in vitro and a myeloma cell, and which is more efficient and practical than the conventional methods, more specifically a method of producing an antibody-producing hybridoma, which includes fusing a B cell ... 02/01/07 - 20070026454 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host ... 01/25/07 - 20070020695 - Compositions and methods for detecting stress-inducible proteins Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B′ antibodies to defined epitopes permits a variety of in vitro and in ... 01/25/07 - 20070020694 - Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of ... 01/25/07 - 20070020693 - Devices and methods for pharmacokinetic-based cell culture system Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ... 01/25/07 - 20070020692 - Methods of assaying connective tissue growth factor The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders. ... 01/25/07 - 20070020691 - Multiplex determination of lipid specific binding moieties To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease. ... 01/25/07 - 20070020690 - Method for site-specific protein modifications A method for site-specific modification of protein molecules includes providing a protein molecule having at least first and second non-terminal Cys residues at respective first and second sites within the protein molecule, providing a blocking molecule that is suitable to interact with the protein molecule to selectively block the second ... 01/25/07 - 20070020689 - Label-free high throughput biomolecular screening system and method A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a ... 01/25/07 - 20070020688 - Measurement method using biosensor It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the above physiologically active substance, thereby ... 01/25/07 - 20070020687 - Detection of rho proteins The present invention provides methods of detecting activated Rho GTPase proteins by contacting a solid support with a sample comprising an activated Rho GTPase protein. The solid support is linked to an activated Rho GTPase binding peptide. The activated Rho GTPase protein remains associated with the solid support during the ... 01/25/07 - 20070020686 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form ... 01/25/07 - 20070020685 - Secretion of antibodies without signal peptides from bacteria The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal peptide through making use of mutant host strains with altered secretory properties. In particular, the invention provides host cells and methods for obtaining ... 01/25/07 - 20070020684 - Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand binding domain polypeptide in complex with the ligand fluticasone propionate (FP) and a peptide derived from the co-activator TIF2. The GR/FP/TIF2 structure includes ... 01/25/07 - 20070020683 - Monoclonal antibodies for detection of urinary trypsin inhibitors Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof. ... 01/25/07 - 20070020682 - Use of prion conversion modulating agents The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in ... 01/25/07 - 20070020681 - Hydrolytic substrates for an analyte-dependent enzyme activation system wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme ... 01/18/07 - 20070015216 - Isoprenoid biosynthesis The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as ... 01/18/07 - 20070015215 - Modified phycobilisomes and uses therefor This invention provides modified phycobilisomes and phycobilisome complexes that are supramolecular complexes with diverse-spectral properties, and which may optionally be immobilized on a manufactured solid support. The invention provides a versatile set of highly sensitive signal-generating systems and conjugates that may be used as highly detectable tracers and labels, or ... 01/18/07 - 20070015214 - Methods for identifying compounds for regulating muscle mass or function using prostanoid ip receptors Methods for identifying compounds that bind to or activate prostanoid IP receptors and potentially regulate skeletal muscle mass or function are disclosed. Pharmaceutical compositions comprising IP receptor agonists and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using IP receptor as the ... 01/18/07 - 20070015213 - Peptide arrays and methods of preparation The present invention relates to arrays of peptidic molecules and the preparation of peptide arrays using focused acoustic energy. The arrays are prepared by acoustically ejecting peptide-containing fluid droplets from individual reservoirs towards designated sites on a substrate for attachment thereto. ... 01/18/07 - 20070015212 - Mitochondrial markers of ischemia Damage to tissue, such as ischemic damage, can cause the release of mitochondrial proteins. The released proteins can be detected in a sample taken from a subject, indicating that the subject has suffered damage. ... 01/18/07 - 20070015211 - Conformer-specific antibodies and method of use, thereof A number of polypeptides exist in different three-dimensional conformations, or “conformers,” which have different biological functions despite having the same or substantially the same primary polypeptide sequences. The existence of different polypeptide conformers underlies to a variety of disease states, which may be assessed using antibody that is specific for ... 01/18/07 - 20070015210 - Embryoid body - based screen Disclosed are embryoid bodies having a uniform size of approximately 415 nm and comprising genetically modified embryonic stem cells, and methods of making same. The genetically uniform embryoid bodies can be multiplexed as one embryoid body per well in a multiwell format, and used as a high to medium throughput ... 01/18/07 - 20070015209 - Compositions and methods for diagnosing, predicting therapeutic response of, and monitoring autoimmune disease The present invention provides methods of diagnosing the presence of an autoimmune disease in a patient, methods of predicting the response of an autoimmune diseased patient to therapeutic treatment, and methods of monitoring an autoimmune patient's response to therapy. In particular, these methods comprise the use of a glycoprotein from ... 01/18/07 - 20070015208 - Multimarker panel for diabetes type 1 and 2 The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular ... 01/18/07 - 20070015207 - Triazolopyrimidine derivatives The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases. ... 01/18/07 - 20070015206 - Method for detecting and/or removing protien comprising a cross-beta structure from a pharmaceutical composition The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-β structure from a pharmaceutical composition or any of its constituents comprising a protein. Disclosed iss that unwanted and/or toxic side effects of pharmaceuticals are caused by proteins present in the pharmaceutical and adopting ... 01/18/07 - 20070015205 - Crystal structure of phosphodiesterase 5 and use thereof The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by ... 01/11/07 - 20070009963 - Apolipoprotein biopolymer marker indicative of normal human The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 01/11/07 - 20070009962 - Nucleic acid binding polypeptide library The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which ... 01/11/07 - 20070009961 - Identification of targeting component of herbal medicines from simplified hplc spectrum using after flowing through immobilized receptor (aftir) method A novel method of screening herbal composition for a pharmaceutically active component of interest (“target component”) comprises: immobilizing a plurality of receptors of interest on a chip; flowing the herbal composition through the chip to allow binding of the target component with the receptors; disassociating the bound target component from ... 01/11/07 - 20070009960 - Characterising polypeptides Provided is a method for characterising an analyte by matrix assisted laser desorption ionisation (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from ... 01/11/07 - 20070009959 - Methods for producing antibodies The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein ... 01/11/07 - 20070009958 - Support having selectively bonding substance fixed thereto (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.) ... 01/11/07 - 20070009957 - Vectors used to create hybrid constant regions Expression vectors used for expression of mouse Fab libraries and expression of individual clones have portions of mouse constant regions replaced with human constant regions while maintaining desired cloning sites. ... 01/11/07 - 20070009956 - Arginine hydrochloride enhances chaperone-like activity of alpha crystallin The present invention provides that arginine, a biologically compatible molecule that is known to bind to the peptide backbone and negatively charged side-chains, increases the chaperone-like activity of a-crystallin significantly. Arginine, interestingly, restores the activity of mutant protein to a considerable extent. The invention shows the effect of arginine on ... 01/11/07 - 20070009955 - Secreted polypeptide species associated with cardiovascular disorders The invention provides novel human secreted polypeptides comprising an amino acid sequence of SEQ ID NOS. I-10. The polypeptides of the invention circulate at an elevated level in the plasma of patients with cardiovascular disorders. The invention also provides compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for ... 01/04/07 - 20070003981 - Methods and kits for the diagnosis of acute coronary syndrome Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new ... 01/04/07 - 20070003980 - Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior This invention provides methods and compositions for identifying effectors, binding partners, or other molecules that interact with the proteins involved in the chemosensory pathway; examples of proteins involved in the olfactory pathway include odorant binding proteins (OBPs), sensory appendage proteins (SAPs), orthologs of the Drosophila melanogaster Takeout protein (TOLs), odorant ... 01/04/07 - 20070003979 - Trackable optical discs with concurrently readable analyte material Optical discs for diagnostic purposes include analyte material and encoded information. The analyte material is analyzed or investigated by the read beam of an optical disc drive. Tracking is maintained so that encoded information may be read by the optical disc drive assembly. ... 01/04/07 - 20070003978 - Immunological assay for spongiform encephalopathies The invention relates to a method of detecting Transmissable Spongiform Encephalopathies (TSE) in animals, particularly in animal carcasses, using an anti-PrPSC antibody in an immunological assay. Also disclosed is a diagnostic kit for detecting TSE comprising the same antibody. ... 01/04/07 - 20070003977 - Epitope protection assay and method for detecting protein conformations The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent ... 01/04/07 - 20070003976 - Car ligand-binding domain polypeptide co-crystallized with a ligand, and methods of designing ligands that modulate car activity The present invention provides a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide. Also provided is a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the present invention and ... 01/04/07 - 20070003975 - Structured construct and producing method therefor There is provided a construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA. ... 01/04/07 - 20070003974 - Cene-e biopolymer marker indicative of age matched control The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/28/06 - 20060292638 - Sequence #115 as a target for identifying weight modulating compounds Sequence #115, a G protein-coupled receptor, has been identified as a target for identifying weight modulating compounds. Compounds that modulate sequence #115 may be useful for the treatment of obesity and cachexia. Cell-based and cell-free assays are described to identify compounds which bind to and/or activate or inhibit the activity ... 12/28/06 - 20060292637 - Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on ... 12/28/06 - 20060292636 - Monoclonal antibodies, hybridoma cell lines, methods and kits for detecting phytase This invention relates to the field of immunology and more specifically relates to anti-phytase monoclonal antibodies, immunoassay methods, kits, and reagents, for the detection of a phytase from or derived from E. coli phytase, in particular, Quantum™ phytase. The invention further relates to hybridoma cell lines that produce anti-phytase monoclonal ... 12/28/06 - 20060292635 - Stably preserved microspheres In accordance with the present invention, active carboxylic acid ester groups are coupled on the surfaces of microspheres so as to reduce protocols for microsphere processing, control side reactions, and stably preserve beads containing active carboxylic acid ester groups. Further, microspheres labeled with at least one fluorescent dye cage in ... 12/28/06 - 20060292634 - Structure for presenting desired peptide sequences Means and methods for generating binding peptide associated with a suitable core region are disclosed, the resulting proteinaceous molecule and uses thereof. A solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of ... 12/28/06 - 20060292633 - Method for modulating process mediated by farnesoid activated receptors Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway ... 12/28/06 - 20060292632 - Method for ascertaining the orientation of molecules in biological specimens A method of ascertaining the orientation of molecules in a biological specimen by total internal reflection includes focusing illuminating light through an objective in different positions in a plane of a pupil of the objective so as to generate a plurality of respective differently oriented evanescent fields in the specimen. ... 12/28/06 - 20060292631 - Elastin peptide fingerprints and analysis methods for mmp12 related to copd Methods for producing and using protein/peptide fingerprints, allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive Pulmonary Disease (COPD), especially for the enzyme MMP12. ... 12/28/06 - 20060292630 - Biosensor and method of analyte measuring A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part ... 12/28/06 - 20060292629 - Chimeric polypeptides and their use The present invention concerns chimeric molecules that contain a preferential polypeptidic region, consisting of a specific affinity for the binding to specific DNA sequences, of a preferential polypeptidic region consisting of a DNA modifying activity, and this chimeric molecule is capable to cross biological membranes due to the presence of ... 12/21/06 - 20060286607 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and ... 12/21/06 - 20060286606 - Clandestine laboratory (clan-lab) home test kit system, protocol, method and apparatus This invention is comprised of a system, protocol, method and apparatus for the assessment of properties that may have been, or are being, subject to clandestine drug manufacturing and/or processing activities. The invention includes a comprehensive home test kit to be used in or upon a suspect premises to detect, ... 12/21/06 - 20060286605 - Calcium biosensor polypeptides and methods of use The invention features methods and compositions for determining states of intracellular calcium stores in a eukaryotic cell. Also provided are methods for identifying an agent (e.g., a gene product or small molecule compound) that modulates intracellular calcium store levels (e.g., by modulating store operated calcium (SOC) influx), as well as ... 12/21/06 - 20060286604 - Lectin binding to choroidal neovascularization The present invention involves the identification of choroidal neovascularization (CNV) based on lectin binding patterns in choroidal and/or Bruch's membranes. The use of lectins to target therapeutic agents to CNV also is disclosed. ... 12/21/06 - 20060286603 - Combinatorial libraries of monomer domains Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or ... 12/21/06 - 20060286602 - Method and markers for the diagnosis of renal diseases Certain embodiments of the invention relate to means and methods for the diagnosis of a renal disease, particularly to differential diagnosis. Renal diseases of particular interest in the context of the invention are IgA-nephropathy, membranous glomerulonephritis (MGN), minimal-change-disease (MCD), focal segemental glomerulosclerosis (FSGS), and diabetic nephropathy. Particularly, the method comprises ... 12/21/06 - 20060286601 - Prolyl endopeptidase mediated destruction of t cell epitopes in whole gluten Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) ... 12/21/06 - 20060286600 - High throughput one-hybrid system The invention relates to a new high throughput yeast one-hybrid screening system. ... 12/14/06 - 20060281135 - Methods for diagnosing and treating cerebrovascular events based on nr2 peptides Methods and kits for diagnosing and treating cerebrovascular events, and for defining the time and anatomical location of an event, are provided based on the detection and quantification of bound or total and unbound NR2 peptides in biological fluids. The methods are optionally performed in conjunction with neurological scoring and ... 12/14/06 - 20060281134 - Method for analyzing biological data sets The present invention relates to methods for analyzing biological data sets, and more specifically for identifying biomolecular differences between biological samples. In particular, the present invention is based in part, on the discovery that Markov's Inequality, and in certain illustrative aspects Chebyshev's Inequality, can be used to analyze biological data ... 12/14/06 - 20060281133 - Targeted fusion proteins and methods for the characterization of cellular membrane domains Cell membranes containing glycolipid-enriched membrane (GEM) and non-glycolipid-enriched membrane (non-GEM) domains are targeted using fusion proteins that are anchored in the cell membrane. Fusion proteins to target GEM (or non-GEM) domains are comprised of a selected fluorescent polypeptide, a membrane-targeting sequence of p56Lck (or pp60c-Src for non-GEM domains) and a ... 12/14/06 - 20060281132 - Method of immunoreaction measurement and, for use therein, reagent, kit and optical cell In the present invention, there is provided a method for measuring, under an acidic pH condition, a subject substance in a specimen. The method includes: step A for forming a reaction system by mixing the specimen and an antibody against the subject substance in the specimen; and step B for ... 12/14/06 - 20060281131 - Novel anti-feline albumin antibodies and methods of detecting early renal disease The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with ... 12/14/06 - 20060281130 - Metod of modulation of interaction between receptor and ligand The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the ... 12/07/06 - 20060275831 - Complement c3 precursor biopolymer markers predictive of type ii diabetes The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/07/06 - 20060275830 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and ... 12/07/06 - 20060275829 - Combinatorial library for proteomic investigations The present invention relates to solid-phase combinatorial peptide libraries synthesized on chromatography beads and their use to prepare samples for proteomic investigations. ... 12/07/06 - 20060275828 - Use of a fluorescent protein for detecting interactions between a target protein and its ligand A fluorescent protein selected in particular among the autofluorescent proteins for detecting the non-covalent interaction between a target protein marked by the fluorescent protein and one of its ligands marked by a marker consisting of: either a molecule capable of absorbing the light emitted by the fluorescent protein, or a ... 12/07/06 - 20060275827 - Teal fluorescent proteins (mtfp1) The present invention provides an isolated nucleic acid sequence encoding a non-oligomerizing Clavularia teal fluorescent protein (mTFP) variant having a tyrosine-derived chromophore, as well as fragments and derivatives thereof Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell ... 12/07/06 - 20060275826 - Artificial antibody comprising complementary peptide A method for detecting an antigen using a complementary peptide reactive to a target protein as an artificial antibody. ... 12/07/06 - 20060275825 - Proteolipid membrane and lipid membrane biosensor The invention provides compositions and methods for detection of interaction of molecules. ... 12/07/06 - 20060275824 - Detection and recognition of analytes The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. ... 12/07/06 - 20060275823 - Selection of peptides with antibody-like properties The present invention provides a highly sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. Utilizing an expression-repression readout system, the inventors have screened libraries of peptides and identified relatively small peptide molecules that bind to the provided target. ... 12/07/06 - 20060275822 - Fluorescent indicator using fret It is an object of the present invention to provide a fluorescent indicator that is based on homo FRET (fluorescence resonance energy transfer) using fluorescent molecules with a small stokes' shift, thereby developing a visualization system for intermolecular interaction. The present invention provides a fluorescent indicator formed by fusing fluorescent ... 12/07/06 - 20060275821 - Method for isolating subpopulations of proteins that engage in protein-protein interactions The invention provides a method for isolating and identifying proteins participating in protein-protein interactions in a complex mixture. The method uses a chemically reactive supporting matrix to isolate proteins that in turn non-covalently bind other proteins. The supporting matrix is isolated, and the non-covalently bound proteins are subsequently released for ... 11/30/06 - 20060269966 - Optical biosensor for biomolecular interaction analysis Biomolecular and other interactions are analyzed with a simpler construction. A biotic sample is fixed to noble metal nanoparticles, and light is irradiated from a light source to the noble metal nanoparticles through an optical fiber. Light obtained after reflection of the irradiated light by the noble metal nanoparticles is ... 11/30/06 - 20060269965 - Water relaxation-based sensors This invention relates to magnetic resonance-based sensors and related methods. ... 11/30/06 - 20060269964 - Systems and methods for characterization of molecules The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as ... 11/30/06 - 20060269963 - Composition for the diagnosis of retinal vascular disease comprising aldolase and method for diagnosis using it Disclosed is a composition comprising an aldolase protein for diagnosing retinal vascular disease. Also, the present invention discloses a kit comprising the protein for diagnosing retinal vascular disease, and a method for diagnosing retinal vascular disease comprising bringing a blood sample into contact with the aldolase protein and quantitatively analyzing ... 11/23/06 - 20060263826 - Antibody protein analysis chip The various embodiment described herein disclose an antibody protein analysis chip. The analysis chip comprises a substrate having a plurality of layers. At least one layer is a conductive layer comprising a conductive material. The analysis chip also comprises a main channel (straight-line and S-shaped configurations) etched in the conductive ... 11/23/06 - 20060263825 - Caries risk test for predicting and assessing the risk of disease Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The method comprises providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of said saliva with one or more lectins under conditions that allow said one ... 11/23/06 - 20060263824 - Method for the use of information derived by the application of a probability law suitable for chiral selection and methods and systems employing same A method of identifying molecules having enantion-discriminating regions comprising applying the chiral probability law disclosed herein to a plurality of molecules thereby identifying the molecules having enantio-discriminating regions. ... 11/16/06 - 20060257940 - Transformed shigella A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain of Shigella. The genome of the wild strain of Shigella is transformed so that it cannot substantially invade cells of ... 11/16/06 - 20060257939 - Spatially addressable combinatorial chemical array in cd-rom format A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also ... 11/16/06 - 20060257938 - Method of screening for drugs that block ligand binding to a lipid binding protein Methods are disclosed to screen for drugs that interfere with the binding between a specific lipid-binding protein and a selected ligand. Successful candidates have potential in disease treatments, particularly diabetes and some forms of cancer. ... 11/16/06 - 20060257937 - Focused libraries of genetic packages Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and ... 11/16/06 - 20060257936 - Methods, products and treatments for diabetes The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided. ... 11/16/06 - 20060257935 - Hematopoietic factor production promoter The present invention provides methods of screening for enhancers and/or inhibitors of a hematopoietic factor production promoter comprising arginine as an active ingredient. Arginine is an excellent hematopoietic factor production promoter, because it has high safety, can be orally administered, and is widely used. ... 11/16/06 - 20060257934 - Cell-based assay for the quantitative high throughput screening of gamma-aminobutyric acid-induced halide transport The present invention is directed to a rapid, quantitative screening procedure of γ-aminobutyric acid (GABA)-mediated halide transport in cells with the use of a conventional 384-well fluorescence plate reader (FLIPR). The halide sensor is a novel yellow fluorescent protein (YFP) with mutations at positions 46/148/152 that exhibits bright fluorescence at ... 11/16/06 - 20060257933 - |