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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay Involving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding AssayInvolving Antigen-antibody Binding, Specific Binding Protein Assay Or Specific Ligand-receptor Binding Assay patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.04/19/07 - 20070087389 - Control system using immune network and control method To provide a new method for autonomously controlling the behavior of a control target device based on a stimulating action and a suppressing action among antibodies in an immune network, an operating unit 3 calculates an antibody concentration ai(t) serving as an index for selecting an antibody module ABi, while ... 04/19/07 - 20070087388 - G protein coupled receptor The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same. ... 04/19/07 - 20070087387 - Method for the early detection of renal disease using proteomics A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins ... 04/19/07 - 20070087386 - Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and ... 04/19/07 - 20070087385 - Spherical and magnetical silicagel carriers having an increase surface for purifying nucleic acids The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to ... 04/19/07 - 20070087384 - Cynomolgus monkey dickkope-4, nucleotides encoding same, and uses thereof The cynomolgus monkey Dickkopf-4 (cDkk-4) protein, isolated nucleic acid molecules which encode the cDkk-4 protein, and recombinant vectors and hosts comprising DNA encoding the cDkk-4 protein are disclosed. Also disclosed are methods for identifying analytes which interfere with the interaction between the cDkk-4 protein and a homologous or heterologous Dkk ... 04/19/07 - 20070087383 - Immunoassay The invention provides a method for detecting a hapten in a sample comprising the steps of: a) providing a sample potentially containing the hapten; b) providing a pre-determined amount of a first moiety, said first moiety being bound to a signaller and separated therefrom by a first linker, which first ... 04/19/07 - 20070087382 - Molecule array and method for producing the same The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid ... 04/19/07 - 20070087381 - Methods for constructing scdb libraries Bispecific diabody libraries can be constructed from scFv libraries efficiently and without troublesome procedures by a single treatment, placing restriction enzyme sites appropriately for antigen-encoding regions. ... 04/19/07 - 20070087380 - Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, ... 04/12/07 - 20070082365 - Protein scaffolds for antibody mimics and other binding proteins Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands. ... 04/12/07 - 20070082364 - Antibody and use thereof The antibody of the present invention, which specifically reacts with a partial peptide at the N-terminal region or the C-terminal region of NPW, which enables to quantify NPW with highly sensitivity and specifically. Moreover, this antibody is useful as an agent for preventing/treating infertility, renal edema, digestive ulcer, gastric hyperacidity, ... 04/12/07 - 20070082363 - Secreted polypeptide species reduced cardiovascular disorders The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and treatment of cardiovascular disorders. ... 04/12/07 - 20070082362 - Modified soluble t cell receptor The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain ... 04/05/07 - 20070077599 - Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith The present invention relates to optical bio-disc systems and related methods and to immobilizing receptor molecules. When a sample is injected into a fluidic circuit, the target agent binds to a capture probe bound in a capture zone. A signal is generated from tags attached to a reporter probe that ... 04/05/07 - 20070077598 - Methods of diagnosis, prognosis and treatment of cardiovascular disease The invention provides methods for diagnosis or prognosis of cardiovascular disease involving the detection of an elevated amount of MIC-1 in a test body sample. The invention also provides methods for treatment of cardiovascular disease and other chronic inflammatory disease. ... 04/05/07 - 20070077597 - Method for identifying modulators of g protein coupled receptor signaling This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these ... 04/05/07 - 20070077596 - Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, ... 04/05/07 - 20070077595 - Miniaturized spectometer using optical waveguide and integrated raman system on-chip One embodiment relates to an analyzer having an interferometer, a detector and a microprocessor, wherein the analyzer does not contain a spectrometer having a dispersive grating, the interferometer is to create a phase shift in an original spectrum of electromagnetic radiation emitted from a sample and Fourier transform the original ... 04/05/07 - 20070077594 - Electroluminescent device The invention relates to a matrix of electroluminescent organic material having quantum dots embedded therein. Electrodes provide electrons and holes to the matrix forming excitons to be transferred to the quantum dots. The invention provides transfer molecules on the quantum dots facilitating the transfer of excitons from the electroluminescent organic ... 04/05/07 - 20070077593 - Substrate as a ligate carrier Described is a substrate for use as a ligate carrier in a method for detecting ligate-ligand association events, having test sites 24 disposed on the substrate and having ligates 26 bound to the surface of the test sites 24, at least two types of test sites 24 being provided, the ... 04/05/07 - 20070077592 - Hemipteran glutamate decarboxylase Novel nucleic acid sequences encoding hemipteran L-glutamate decarboxylases, and the amino acid sequence of such protein are disclosed. Methods of making and using the same are disclosed. ... 03/29/07 - 20070072242 - Immunoassay method and kit to leucomalachite green and malachite green The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with leucomalachite green and malachite green. ... 03/29/07 - 20070072241 - Diagnostic methods for age related macular degeneration Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in ... 03/29/07 - 20070072240 - Method for producing an in vitro expression library The present invention relates to an antibody expression library derived from a patient which has been immunochallenged with one or more foreign antigens associated with a particular disease or foreign agent, wherein said patients have been immunochallenged with the foreign antigens at a time point such that they still contain ... 03/29/07 - 20070072239 - Pharmaceutical compositions and methods of using secreted frizzled related protein Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be ... 03/29/07 - 20070072238 - Wnt-frizzled chimera The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer. ... 03/29/07 - 20070072237 - Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6 The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6 ... 03/29/07 - 20070072236 - Novel type ii na/pi cotransporters and type ii na/pi cotransporter expression regulatory factors The present invention provides novel type IIc Na/Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na/Pi ... 03/29/07 - 20070072235 - Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of ... 03/29/07 - 20070072234 - Protein capable of binding plasticizer The present invention provides a protein having a binding capacity to a plasticizer, which has been conferred with useful properties for measuring, quantifying, or concentrating a plasticizer, such as high sensitivity, low cross-reactivity, high tolerance for interferents, and high tolerance for solvents. Specifically, the present invention provides a modified protein ... 03/22/07 - 20070065880 - Compositions and methods relating to elutable carbohydrate-binding proteins Compositions and methods are provided for creating and identifying mutant carbohydrate-binding proteins that reversibly bind to carbohydrate substrates under conditions where the native protein remains bound. Examples of modified chitin-binding domains are provided which can be eluted from chitin in the presence of a reducing agent or at a pH ... 03/22/07 - 20070065879 - Marker for inflammatory conditions Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. ... 03/22/07 - 20070065878 - Cellular libraries of peptide sequences (clips) and methods of using the same The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. ... 03/22/07 - 20070065877 - Microarray having a base cleavable succinate linker There is disclosed a microarray having base cleavable succinate linkers. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Amino moieties are attached to the reactive hydroxyl groups. Preferably the ... 03/15/07 - 20070059772 - Phosphorylated glyoxalase i and its use The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate MG-modification of proteins (AGE formation) and consequent cell death, especially upon stress such as oxidative stress, or upon TNF treatment. ... 03/15/07 - 20070059771 - Protein o-sulfonation Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference ... 03/15/07 - 20070059770 - Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... 03/15/07 - 20070059769 - High throughput glycan microarrays The invention provides arrays of glycans for detecting entities that bind to glycans. In some embodiments, the arrays can be used to detect disease, blood types, antibodies, bacterial or viral infection, cancer, and the like. The invention also provides methods and kits for such detection. In another embodiment, the invention ... 03/15/07 - 20070059768 - Broad host range vectors for shotgun and expression library cloning in gram negative bacteria The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments, ... 03/15/07 - 20070059767 - Method of identifying n-terminal probnp The invention relates to a method of identifying N-terminal proBNP in a sample with at least two antibodies that detect different epitopes of the N-terminal proBNP. The method is used to differentiate or classify samples of healthy individuals and samples of patients of NYHA classes I to IV. The invention ... 03/15/07 - 20070059766 - Mixture of binding proteins Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and ... 03/15/07 - 20070059765 - Liposome-based microarray and methods of use thereof This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject ... 03/15/07 - 20070059764 - Electrospray coating of aerosols for labeling and identification A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to ... 03/15/07 - 20070059763 - Cellomics system In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction ... 03/15/07 - 20070059762 - Insulin resistance curative and method of screening the same The present invention provides a screening method for a compound which is highly safe and has a prophylactic or therapeutic effect on diabetes, and a highly safe pharmaceutical composition for the prophylaxis or treatment of diabetes. Specifically, a drug for the prophylaxis or treatment of diabetes, which contains, as an ... 03/15/07 - 20070059761 - Storage and use of colloids The present invention discloses compositions and methods for enabling the longterm storage and/or use of colloid particles without substantial degradation of their performance, for example, by chemical or physical degradation, by particle aggregation, changes in pH and/or relative humidity, changes in salt concentration, and/or by a decrease in the binding ... 03/08/07 - 20070054320 - Cytokine zalpha11 ligand antibodies Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller ... 03/08/07 - 20070054319 - Light-activated cation channel and uses thereof The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention ... 03/08/07 - 20070054318 - Soluble low-density lipoprotein receptor related protein binds directly to alzheimer's amyloid-beta peptide A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-β peptide (Aβ). This binding may be used to detect Aβ or to separate Aβ from the rest of a subject's body. In Alzheimer's disease, it may be used to provide diagnostic results by detecting Aβ, ... 03/08/07 - 20070054317 - Electrochemical affinity biosensor system and methods The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated ... 03/08/07 - 20070054316 - Radical activated cleavage of biologics and microfluidic devices using the same Disclosed is a cleavage method for biological sample characterization using hydroxyl radical activated cleavage in place of traditional enzymatic approaches. The hydroxyl radicals are generated from a semiconductor excited by an energy source. A microfluidic device for the two-dimensional separation of biological samples by hydroxyl radical activated cleavage is also ... 03/08/07 - 20070054315 - Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier. ... 03/01/07 - 20070048800 - Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a ... 03/01/07 - 20070048799 - Cytokine receptor zcytor19 Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor ... 03/01/07 - 20070048798 - Il-21 production in prokaryotic hosts The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, ... 03/01/07 - 20070048797 - Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. Embodiments of the invention provide methods for detecting and ... 03/01/07 - 20070048796 - Biosensor It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting ... 03/01/07 - 20070048795 - Immunoaffinity separation and analysis compositions and methods The present invention provides compositions and methods for immunoaffinity separation of targets from mixtures for enrichment, identification, quantification, and analysis. In particular, disclosed are avian IgY antibodies coupled to solid supports and their methods of use. Further disclosed are systems and methods for fractionating or enrichment a mixture of biological ... 03/01/07 - 20070048794 - Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between ... 03/01/07 - 20070048793 - Compositions and methods for biocatalytic engineering Provided herein are compositions and methods for metabolic pathway engineering. The methods involve combining two or more cells expressing potential pathway proteins extracellularly in the presence of reactants. Also provided are libraries of cells expressing a plurality of pathway components and/or a plurality of variants of a given pathway component ... 03/01/07 - 20070048792 - Preparing biological samples for analysis Methods and devices for preparing a biological sample for analysis are described. The biological sample from an organism has at least macromolecule having a primary structure that naturally degrades after the sample is removed from the organism. The method includes causing the biological sample to adopt a shape to permit ... 03/01/07 - 20070048791 - Crystal structures and models for fc receptors and uses thereof in the design or identification of fc receptor modulator compounds The invention relates to the determination of the three-dimensional structures of Fc receptor proteins, particularly wild-type FcγRIIa, by X-ray crystallography and the use of the structure in identifying and modifying agents for modulating the biological activity of Fc receptors. Also disclosed is a novel dimeric structure for FcγRIIa and novel ... 03/01/07 - 20070048790 - Device for measuring nanometer level pattern-dependent binding reactions The present invention is directed to a device comprising (a) a substrate having a surface and (b) an ordered array of posts over the surface, wherein the posts are capable of binding a protein or small molecule ligand, and wherein the pitch between adjacent posts is less than about 100 ... 03/01/07 - 20070048789 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with, ... 03/01/07 - 20070048788 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with, ... 03/01/07 - 20070048787 - Multi-analyte affinity column A multi-analyte column is disclosed. The column may contain at least one unit of resin having ochratoxin specific affinity and, for each unit of resin having ochratoxin specific affinity, the column further contains about 0.95 to 1.05 units of resin containing antibody having specificity for zearalenone, about 1.9 to 2.1 ... 03/01/07 - 20070048786 - Systems and methods for fractionation of protein mixtures Methods for proteomics analysis, including fractionation or separation of one or more biomolecules that exist in a mixture, for example, using aqueous multi-phase partitioning, which results in isolation of one or more preselected biomolecules, followed by further proteomics analysis. ... 03/01/07 - 20070048785 - Anti-il-13 antibodies and complexes Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed. ... 02/22/07 - 20070042431 - Methods for reducing complexity of a sample using small epitope antibodies The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes. ... 02/22/07 - 20070042430 - Apparatus and method for single-step immunosorbent assay for single and multiple analytes The present invention discloses an apparatus and method for minimizing or eliminating steps in immunosorbent assays by eliminating both the need to attach target molecules to the test well and the need to remove unbound antibodies through rinsing. The single-step immunosorbent assay (SISA) includes the step of mixing the immunologic ... 02/22/07 - 20070042429 - Assay for differentiating alzheimer's and alzheimer's-like disorders The invention relates to an assay for discriminating between Alzheimer's disease (AD) patients, patients with AD-Like disorders that express symptoms like AD, and non-demented age-matched controls (Normal). The method is based on the use of 2-dimensional (2D) gel electrophoresis to separate the complex mixture of proteins found in blood serum, ... 02/22/07 - 20070042428 - Treatment of proliferative disorders Inhibitors of cIAP-1 and methods and compositions for treating proliferative disorders. ... 02/22/07 - 20070042427 - Microfluidic laminar flow detection strip The present invention relates to microfluidic laminar flow detection strip devices and methods for using and making the same. The disclosed devices comprise: a first inlet; a microfluidic channel having a first end and a second end, wherein the first end is fluidly connected to the first inlet; a bellows ... 02/22/07 - 20070042426 - Biomarkers and assays for myocardial infarction Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of myocardial infarction (MI). A multiplexed, mass spectrometric immunoassay (MSIA) ... 02/22/07 - 20070042425 - Diagnostic method for brain damage-related disorders A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, selected from A-FABP, E-FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofilament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Nucleoside diphosphate kinase A, Glutathione ... 02/22/07 - 20070042424 - Method of selectively assaying adiponectin multimers We have discovered a “human adiponectin ELISA kit”, which can specifically measure adiponectin in human blood serum (or blood plasma) or in extracted fluid from lipocytes or culture supernatant fluid. After fractioning human serum by use of gel filtration column, each fraction was measured by the present kit, and as ... 02/22/07 - 20070042423 - Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep-like (rnpep-like) The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological ... 02/15/07 - 20070037218 - Human gene critical to fertility Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using ... 02/15/07 - 20070037217 - Structure-based selection and affinity maturation of antibody library The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a ... 02/15/07 - 20070037216 - Dual expression vector system for antibody expression in bacterial and mammalian cells The present invention provides a dual expression vector, and methods for its use, for the expression and secretion of a full-length polypeptide of interest in eukaryotic cells, and a soluble domain or fragment of the polypeptide in bacteria. When expressed in bacteria, transcription from a bacterial promoter within a first ... 02/15/07 - 20070037215 - Assay particles and methods of use The invention provides assay particles useful, for example, for detecting analytes and binding molecule interactions. One type of assay particle includes a core portion encased by a shell portion, wherein the shell portion comprises an inorganic phosphor that binds selectively to a target molecule. Another type of an assay particle ... 02/15/07 - 20070037214 - Generation and selection of protein library in silico The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein ... 02/15/07 - 20070037213 - Method of analyzing protein and kit for analyzing protein The expression and the phosphorylation level of a target protein are determined without performing complicated operations involving risk; the expression and the phosphorylation level of the target protein are simultaneously determined, by separating and detecting the specific protein from other proteins different from the specific protein, and by specifically detecting ... 02/15/07 - 20070037212 - Human t2r receptors recognizing a class of bitter molecules from coffee The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these ... 02/15/07 - 20070037211 - Peptide antagonists for inhibiting heat shock protein (hsp 16.3) of mycobacterium tuberculosis A process to identify peptide antagonists of Hsp16.3, a chaperon protein necessary for the survival of Mycobacterium tuberculosis in the dormant phase is described. Affinity selection of a 7-mer and a 12-mer random peptide libraries displayed on bacteriophage M13 was performed using recombinant Hsp16.3 as template and two peptide phage ... 02/15/07 - 20070037210 - Cytokine receptor modulators, method of identifying same, and method of modulating cytokine receptors activity with same The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining ... 02/15/07 - 20070037209 - Soluble ectodomain fragments of met and uses thereof The invention relates a fragment derived from the MET ectodomain which the inventors have found is capable, in monomer form, of binding to HGF/SF either in the presence or absence of heparin. The availability of soluble, monomeric forms of the MET receptor enabled studies of its solution properties and HGF/SF ... 02/15/07 - 20070037208 - Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NT-proBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac ischemia. ... 02/15/07 - 20070037207 - Latex reagent for adiponectin analysis and method of adiponectin analysis A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing adiponectin, comprising (1) obtaining a biological liquid possibly containing adiponectin, and (2) bringing the biological liquid, while maintaining the state in which the ... 02/15/07 - 20070037206 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, ... 02/08/07 - 20070031893 - Method for measuring reaction rate coefficient in analysis utilizing total reflection attenuation An object of the present invention is to provide a method for measuring a reaction rate coefficient in an analysis utilizing total reflection attenuation, which is capable of calculating the reaction rate coefficient speedily and accurately. The present invention provides a method for measuring adsorption rate coefficient (Ka) and diffusion ... 02/08/07 - 20070031892 - Novel coumarin-based amino acids for use in enzyme activity and substrate specificity assays The design, synthesis, and utilization of a novel coumarin-based amino acid and its fluorinated derivatives for use in enzyme activity and substrate specificity assays are described. The synthesis is both facile and high-yielding and allows for the production of a highly fluorescent phosphorylated amino acid that can be incorporated into ... 02/08/07 - 20070031891 - Method of analyzing ligand in sample and apparatus for analyzing ligand in sample A sample analyzing method capable of high-precision analysis without being affected by vibration and optical design is provided. In the sample analyzing method, a sample containing a ligand is caused to bind to a receptor that can bind specifically to the ligand, and a change caused by binding of the ... 02/08/07 - 20070031890 - Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also ... 02/01/07 - 20070026464 - Biologically active synthetic thyrotropin and cloned gene for producing same Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described. ... 02/01/07 - 20070026463 - Compositions and methods of mutant nogo-66 domain proteins To facilitate the study of Nogo-66 interaction with its neuronal receptors, and to explore therapeutic opportunities, the present invention provides mutant human Nogo-66 domain-based proteins that do not aggregate during isolation or purification procedures, and methods for using these proteins. Aggregates of Nogo-66 domain containing proteins do not effectively or ... 02/01/07 - 20070026462 - Gas 1 universal leader Disclosed is a polynucleotide molecule comprising a promoter operably linked to a nucleic acid sequence encoding a GAS1 secretion signal peptide, wherein said promoter is not a rhamnose promoter. ... 02/01/07 - 20070026461 - Production of motif-specific and context-independent antibodies using peptide libraries as antigens A method is provided for producing motif-specific, context-independent antibodies that recognize a plurality of peptides or proteins within a genome that contain the same post-translationally modified motif. The method includes the step of immunizing a host with a degenerate peptide library antigen featuring (i) a fixed target motif containing one ... 02/01/07 - 20070026460 - Use of ionic liquids for protein extraction The present invention relates to a method for the extraction of proteins, protein fragments and/or peptides from biological samples, where the extractants employed are ionic liquids of the general formula K+A−, to a kit for the extraction of proteins, protein fragments and/or peptides, and to the use thereof. ... 02/01/07 - 20070026459 - Methods for determination of an analyte The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to ... 02/01/07 - 20070026458 - Assessing insulin resistance using biomarkers The invention encompasses novel biomarkers and methods for assessing insulin resistance in a subject. The novel biomarkers of the invention include various plasma constituent (e.g., insulin, glucose, lactate and/or triglyceride) concentrations. The methods of the invention include measuring various plasma constituent concentrations and calculating a predicted euglycemic hyperinsulinemic clamp glucose ... 02/01/07 - 20070026457 - Screening method The present invention provides a method of screening an agent for the prevention/treatment of cancer. More specifically, the present invention provides a screening method/screening kit for screening a compound or its salt that changes the binding properties of a protein comprising the same or substantially the same amino acid sequence ... 02/01/07 - 20070026456 - Method of biomolecule analysis and method of identifying biomolecule therewith A biomolecule is analyzed with high accuracy. A biomolecule is analyzed with high likelihood. A biomolecule as an analysis subject is modified with a marker binding or adsorbing to only its specific portion (S101). Next, the biomolecule modified with the marker is developed on a base plate (S102). The arrangement ... 02/01/07 - 20070026455 - Method of producing hybridoma and utilization thereof The present invention provides a method of producing an antibody-producing hybridoma, which includes fusing a B cell immunized in vitro and a myeloma cell, and which is more efficient and practical than the conventional methods, more specifically a method of producing an antibody-producing hybridoma, which includes fusing a B cell ... 02/01/07 - 20070026454 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host ... 01/25/07 - 20070020695 - Compositions and methods for detecting stress-inducible proteins Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B′ antibodies to defined epitopes permits a variety of in vitro and in ... 01/25/07 - 20070020694 - Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of ... 01/25/07 - 20070020693 - Devices and methods for pharmacokinetic-based cell culture system Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ... 01/25/07 - 20070020692 - Methods of assaying connective tissue growth factor The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders. ... 01/25/07 - 20070020691 - Multiplex determination of lipid specific binding moieties To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease. ... 01/25/07 - 20070020690 - Method for site-specific protein modifications A method for site-specific modification of protein molecules includes providing a protein molecule having at least first and second non-terminal Cys residues at respective first and second sites within the protein molecule, providing a blocking molecule that is suitable to interact with the protein molecule to selectively block the second ... 01/25/07 - 20070020689 - Label-free high throughput biomolecular screening system and method A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a ... 01/25/07 - 20070020688 - Measurement method using biosensor It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the above physiologically active substance, thereby ... 01/25/07 - 20070020687 - Detection of rho proteins The present invention provides methods of detecting activated Rho GTPase proteins by contacting a solid support with a sample comprising an activated Rho GTPase protein. The solid support is linked to an activated Rho GTPase binding peptide. The activated Rho GTPase protein remains associated with the solid support during the ... 01/25/07 - 20070020686 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form ... 01/25/07 - 20070020685 - Secretion of antibodies without signal peptides from bacteria The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal peptide through making use of mutant host strains with altered secretory properties. In particular, the invention provides host cells and methods for obtaining ... 01/25/07 - 20070020684 - Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand binding domain polypeptide in complex with the ligand fluticasone propionate (FP) and a peptide derived from the co-activator TIF2. The GR/FP/TIF2 structure includes ... 01/25/07 - 20070020683 - Monoclonal antibodies for detection of urinary trypsin inhibitors Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof. ... 01/25/07 - 20070020682 - Use of prion conversion modulating agents The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in ... 01/25/07 - 20070020681 - Hydrolytic substrates for an analyte-dependent enzyme activation system wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme ... 01/18/07 - 20070015216 - Isoprenoid biosynthesis The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as ... 01/18/07 - 20070015215 - Modified phycobilisomes and uses therefor This invention provides modified phycobilisomes and phycobilisome complexes that are supramolecular complexes with diverse-spectral properties, and which may optionally be immobilized on a manufactured solid support. The invention provides a versatile set of highly sensitive signal-generating systems and conjugates that may be used as highly detectable tracers and labels, or ... 01/18/07 - 20070015214 - Methods for identifying compounds for regulating muscle mass or function using prostanoid ip receptors Methods for identifying compounds that bind to or activate prostanoid IP receptors and potentially regulate skeletal muscle mass or function are disclosed. Pharmaceutical compositions comprising IP receptor agonists and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using IP receptor as the ... 01/18/07 - 20070015213 - Peptide arrays and methods of preparation The present invention relates to arrays of peptidic molecules and the preparation of peptide arrays using focused acoustic energy. The arrays are prepared by acoustically ejecting peptide-containing fluid droplets from individual reservoirs towards designated sites on a substrate for attachment thereto. ... 01/18/07 - 20070015212 - Mitochondrial markers of ischemia Damage to tissue, such as ischemic damage, can cause the release of mitochondrial proteins. The released proteins can be detected in a sample taken from a subject, indicating that the subject has suffered damage. ... 01/18/07 - 20070015211 - Conformer-specific antibodies and method of use, thereof A number of polypeptides exist in different three-dimensional conformations, or “conformers,” which have different biological functions despite having the same or substantially the same primary polypeptide sequences. The existence of different polypeptide conformers underlies to a variety of disease states, which may be assessed using antibody that is specific for ... 01/18/07 - 20070015210 - Embryoid body - based screen Disclosed are embryoid bodies having a uniform size of approximately 415 nm and comprising genetically modified embryonic stem cells, and methods of making same. The genetically uniform embryoid bodies can be multiplexed as one embryoid body per well in a multiwell format, and used as a high to medium throughput ... 01/18/07 - 20070015209 - Compositions and methods for diagnosing, predicting therapeutic response of, and monitoring autoimmune disease The present invention provides methods of diagnosing the presence of an autoimmune disease in a patient, methods of predicting the response of an autoimmune diseased patient to therapeutic treatment, and methods of monitoring an autoimmune patient's response to therapy. In particular, these methods comprise the use of a glycoprotein from ... 01/18/07 - 20070015208 - Multimarker panel for diabetes type 1 and 2 The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular ... 01/18/07 - 20070015207 - Triazolopyrimidine derivatives The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases. ... 01/18/07 - 20070015206 - Method for detecting and/or removing protien comprising a cross-beta structure from a pharmaceutical composition The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-β structure from a pharmaceutical composition or any of its constituents comprising a protein. Disclosed iss that unwanted and/or toxic side effects of pharmaceuticals are caused by proteins present in the pharmaceutical and adopting ... 01/18/07 - 20070015205 - Crystal structure of phosphodiesterase 5 and use thereof The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by ... 01/11/07 - 20070009963 - Apolipoprotein biopolymer marker indicative of normal human The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 01/11/07 - 20070009962 - Nucleic acid binding polypeptide library The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which ... 01/11/07 - 20070009961 - Identification of targeting component of herbal medicines from simplified hplc spectrum using after flowing through immobilized receptor (aftir) method A novel method of screening herbal composition for a pharmaceutically active component of interest (“target component”) comprises: immobilizing a plurality of receptors of interest on a chip; flowing the herbal composition through the chip to allow binding of the target component with the receptors; disassociating the bound target component from ... 01/11/07 - 20070009960 - Characterising polypeptides Provided is a method for characterising an analyte by matrix assisted laser desorption ionisation (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from ... 01/11/07 - 20070009959 - Methods for producing antibodies The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein ... 01/11/07 - 20070009958 - Support having selectively bonding substance fixed thereto (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.) ... 01/11/07 - 20070009957 - Vectors used to create hybrid constant regions Expression vectors used for expression of mouse Fab libraries and expression of individual clones have portions of mouse constant regions replaced with human constant regions while maintaining desired cloning sites. ... 01/11/07 - 20070009956 - Arginine hydrochloride enhances chaperone-like activity of alpha crystallin The present invention provides that arginine, a biologically compatible molecule that is known to bind to the peptide backbone and negatively charged side-chains, increases the chaperone-like activity of a-crystallin significantly. Arginine, interestingly, restores the activity of mutant protein to a considerable extent. The invention shows the effect of arginine on ... 01/11/07 - 20070009955 - Secreted polypeptide species associated with cardiovascular disorders The invention provides novel human secreted polypeptides comprising an amino acid sequence of SEQ ID NOS. I-10. The polypeptides of the invention circulate at an elevated level in the plasma of patients with cardiovascular disorders. The invention also provides compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for ... 01/04/07 - 20070003981 - Methods and kits for the diagnosis of acute coronary syndrome Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new ... 01/04/07 - 20070003980 - Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior This invention provides methods and compositions for identifying effectors, binding partners, or other molecules that interact with the proteins involved in the chemosensory pathway; examples of proteins involved in the olfactory pathway include odorant binding proteins (OBPs), sensory appendage proteins (SAPs), orthologs of the Drosophila melanogaster Takeout protein (TOLs), odorant ... 01/04/07 - 20070003979 - Trackable optical discs with concurrently readable analyte material Optical discs for diagnostic purposes include analyte material and encoded information. The analyte material is analyzed or investigated by the read beam of an optical disc drive. Tracking is maintained so that encoded information may be read by the optical disc drive assembly. ... 01/04/07 - 20070003978 - Immunological assay for spongiform encephalopathies The invention relates to a method of detecting Transmissable Spongiform Encephalopathies (TSE) in animals, particularly in animal carcasses, using an anti-PrPSC antibody in an immunological assay. Also disclosed is a diagnostic kit for detecting TSE comprising the same antibody. ... 01/04/07 - 20070003977 - Epitope protection assay and method for detecting protein conformations The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent ... 01/04/07 - 20070003976 - Car ligand-binding domain polypeptide co-crystallized with a ligand, and methods of designing ligands that modulate car activity The present invention provides a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide. Also provided is a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the present invention and ... 01/04/07 - 20070003975 - Structured construct and producing method therefor There is provided a construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA. ... 01/04/07 - 20070003974 - Cene-e biopolymer marker indicative of age matched control The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/28/06 - 20060292638 - Sequence #115 as a target for identifying weight modulating compounds Sequence #115, a G protein-coupled receptor, has been identified as a target for identifying weight modulating compounds. Compounds that modulate sequence #115 may be useful for the treatment of obesity and cachexia. Cell-based and cell-free assays are described to identify compounds which bind to and/or activate or inhibit the activity ... 12/28/06 - 20060292637 - Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on ... 12/28/06 - 20060292636 - Monoclonal antibodies, hybridoma cell lines, methods and kits for detecting phytase This invention relates to the field of immunology and more specifically relates to anti-phytase monoclonal antibodies, immunoassay methods, kits, and reagents, for the detection of a phytase from or derived from E. coli phytase, in particular, Quantum™ phytase. The invention further relates to hybridoma cell lines that produce anti-phytase monoclonal ... 12/28/06 - 20060292635 - Stably preserved microspheres In accordance with the present invention, active carboxylic acid ester groups are coupled on the surfaces of microspheres so as to reduce protocols for microsphere processing, control side reactions, and stably preserve beads containing active carboxylic acid ester groups. Further, microspheres labeled with at least one fluorescent dye cage in ... 12/28/06 - 20060292634 - Structure for presenting desired peptide sequences Means and methods for generating binding peptide associated with a suitable core region are disclosed, the resulting proteinaceous molecule and uses thereof. A solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of ... 12/28/06 - 20060292633 - Method for modulating process mediated by farnesoid activated receptors Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway ... 12/28/06 - 20060292632 - Method for ascertaining the orientation of molecules in biological specimens A method of ascertaining the orientation of molecules in a biological specimen by total internal reflection includes focusing illuminating light through an objective in different positions in a plane of a pupil of the objective so as to generate a plurality of respective differently oriented evanescent fields in the specimen. ... 12/28/06 - 20060292631 - Elastin peptide fingerprints and analysis methods for mmp12 related to copd Methods for producing and using protein/peptide fingerprints, allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive Pulmonary Disease (COPD), especially for the enzyme MMP12. ... 12/28/06 - 20060292630 - Biosensor and method of analyte measuring A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part ... 12/28/06 - 20060292629 - Chimeric polypeptides and their use The present invention concerns chimeric molecules that contain a preferential polypeptidic region, consisting of a specific affinity for the binding to specific DNA sequences, of a preferential polypeptidic region consisting of a DNA modifying activity, and this chimeric molecule is capable to cross biological membranes due to the presence of ... 12/21/06 - 20060286607 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and ... 12/21/06 - 20060286606 - Clandestine laboratory (clan-lab) home test kit system, protocol, method and apparatus This invention is comprised of a system, protocol, method and apparatus for the assessment of properties that may have been, or are being, subject to clandestine drug manufacturing and/or processing activities. The invention includes a comprehensive home test kit to be used in or upon a suspect premises to detect, ... 12/21/06 - 20060286605 - Calcium biosensor polypeptides and methods of use The invention features methods and compositions for determining states of intracellular calcium stores in a eukaryotic cell. Also provided are methods for identifying an agent (e.g., a gene product or small molecule compound) that modulates intracellular calcium store levels (e.g., by modulating store operated calcium (SOC) influx), as well as ... 12/21/06 - 20060286604 - Lectin binding to choroidal neovascularization The present invention involves the identification of choroidal neovascularization (CNV) based on lectin binding patterns in choroidal and/or Bruch's membranes. The use of lectins to target therapeutic agents to CNV also is disclosed. ... 12/21/06 - 20060286603 - Combinatorial libraries of monomer domains Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or ... 12/21/06 - 20060286602 - Method and markers for the diagnosis of renal diseases Certain embodiments of the invention relate to means and methods for the diagnosis of a renal disease, particularly to differential diagnosis. Renal diseases of particular interest in the context of the invention are IgA-nephropathy, membranous glomerulonephritis (MGN), minimal-change-disease (MCD), focal segemental glomerulosclerosis (FSGS), and diabetic nephropathy. Particularly, the method comprises ... 12/21/06 - 20060286601 - Prolyl endopeptidase mediated destruction of t cell epitopes in whole gluten Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) ... 12/21/06 - 20060286600 - High throughput one-hybrid system The invention relates to a new high throughput yeast one-hybrid screening system. ... 12/14/06 - 20060281135 - Methods for diagnosing and treating cerebrovascular events based on nr2 peptides Methods and kits for diagnosing and treating cerebrovascular events, and for defining the time and anatomical location of an event, are provided based on the detection and quantification of bound or total and unbound NR2 peptides in biological fluids. The methods are optionally performed in conjunction with neurological scoring and ... 12/14/06 - 20060281134 - Method for analyzing biological data sets The present invention relates to methods for analyzing biological data sets, and more specifically for identifying biomolecular differences between biological samples. In particular, the present invention is based in part, on the discovery that Markov's Inequality, and in certain illustrative aspects Chebyshev's Inequality, can be used to analyze biological data ... 12/14/06 - 20060281133 - Targeted fusion proteins and methods for the characterization of cellular membrane domains Cell membranes containing glycolipid-enriched membrane (GEM) and non-glycolipid-enriched membrane (non-GEM) domains are targeted using fusion proteins that are anchored in the cell membrane. Fusion proteins to target GEM (or non-GEM) domains are comprised of a selected fluorescent polypeptide, a membrane-targeting sequence of p56Lck (or pp60c-Src for non-GEM domains) and a ... 12/14/06 - 20060281132 - Method of immunoreaction measurement and, for use therein, reagent, kit and optical cell In the present invention, there is provided a method for measuring, under an acidic pH condition, a subject substance in a specimen. The method includes: step A for forming a reaction system by mixing the specimen and an antibody against the subject substance in the specimen; and step B for ... 12/14/06 - 20060281131 - Novel anti-feline albumin antibodies and methods of detecting early renal disease The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with ... 12/14/06 - 20060281130 - Metod of modulation of interaction between receptor and ligand The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the ... 12/07/06 - 20060275831 - Complement c3 precursor biopolymer markers predictive of type ii diabetes The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/07/06 - 20060275830 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and ... 12/07/06 - 20060275829 - Combinatorial library for proteomic investigations The present invention relates to solid-phase combinatorial peptide libraries synthesized on chromatography beads and their use to prepare samples for proteomic investigations. ... 12/07/06 - 20060275828 - Use of a fluorescent protein for detecting interactions between a target protein and its ligand A fluorescent protein selected in particular among the autofluorescent proteins for detecting the non-covalent interaction between a target protein marked by the fluorescent protein and one of its ligands marked by a marker consisting of: either a molecule capable of absorbing the light emitted by the fluorescent protein, or a ... 12/07/06 - 20060275827 - Teal fluorescent proteins (mtfp1) The present invention provides an isolated nucleic acid sequence encoding a non-oligomerizing Clavularia teal fluorescent protein (mTFP) variant having a tyrosine-derived chromophore, as well as fragments and derivatives thereof Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell ... 12/07/06 - 20060275826 - Artificial antibody comprising complementary peptide A method for detecting an antigen using a complementary peptide reactive to a target protein as an artificial antibody. ... 12/07/06 - 20060275825 - Proteolipid membrane and lipid membrane biosensor The invention provides compositions and methods for detection of interaction of molecules. ... 12/07/06 - 20060275824 - Detection and recognition of analytes The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. ... 12/07/06 - 20060275823 - Selection of peptides with antibody-like properties The present invention provides a highly sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. Utilizing an expression-repression readout system, the inventors have screened libraries of peptides and identified relatively small peptide molecules that bind to the provided target. ... 12/07/06 - 20060275822 - Fluorescent indicator using fret It is an object of the present invention to provide a fluorescent indicator that is based on homo FRET (fluorescence resonance energy transfer) using fluorescent molecules with a small stokes' shift, thereby developing a visualization system for intermolecular interaction. The present invention provides a fluorescent indicator formed by fusing fluorescent ... 12/07/06 - 20060275821 - Method for isolating subpopulations of proteins that engage in protein-protein interactions The invention provides a method for isolating and identifying proteins participating in protein-protein interactions in a complex mixture. The method uses a chemically reactive supporting matrix to isolate proteins that in turn non-covalently bind other proteins. The supporting matrix is isolated, and the non-covalently bound proteins are subsequently released for ... 11/30/06 - 20060269966 - Optical biosensor for biomolecular interaction analysis Biomolecular and other interactions are analyzed with a simpler construction. A biotic sample is fixed to noble metal nanoparticles, and light is irradiated from a light source to the noble metal nanoparticles through an optical fiber. Light obtained after reflection of the irradiated light by the noble metal nanoparticles is ... 11/30/06 - 20060269965 - Water relaxation-based sensors This invention relates to magnetic resonance-based sensors and related methods. ... 11/30/06 - 20060269964 - Systems and methods for characterization of molecules The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as ... 11/30/06 - 20060269963 - Composition for the diagnosis of retinal vascular disease comprising aldolase and method for diagnosis using it Disclosed is a composition comprising an aldolase protein for diagnosing retinal vascular disease. Also, the present invention discloses a kit comprising the protein for diagnosing retinal vascular disease, and a method for diagnosing retinal vascular disease comprising bringing a blood sample into contact with the aldolase protein and quantitatively analyzing ... 11/23/06 - 20060263826 - Antibody protein analysis chip The various embodiment described herein disclose an antibody protein analysis chip. The analysis chip comprises a substrate having a plurality of layers. At least one layer is a conductive layer comprising a conductive material. The analysis chip also comprises a main channel (straight-line and S-shaped configurations) etched in the conductive ... 11/23/06 - 20060263825 - Caries risk test for predicting and assessing the risk of disease Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The method comprises providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of said saliva with one or more lectins under conditions that allow said one ... 11/23/06 - 20060263824 - Method for the use of information derived by the application of a probability law suitable for chiral selection and methods and systems employing same A method of identifying molecules having enantion-discriminating regions comprising applying the chiral probability law disclosed herein to a plurality of molecules thereby identifying the molecules having enantio-discriminating regions. ... 11/16/06 - 20060257940 - Transformed shigella A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain of Shigella. The genome of the wild strain of Shigella is transformed so that it cannot substantially invade cells of ... 11/16/06 - 20060257939 - Spatially addressable combinatorial chemical array in cd-rom format A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also ... 11/16/06 - 20060257938 - Method of screening for drugs that block ligand binding to a lipid binding protein Methods are disclosed to screen for drugs that interfere with the binding between a specific lipid-binding protein and a selected ligand. Successful candidates have potential in disease treatments, particularly diabetes and some forms of cancer. ... 11/16/06 - 20060257937 - Focused libraries of genetic packages Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and ... 11/16/06 - 20060257936 - Methods, products and treatments for diabetes The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided. ... 11/16/06 - 20060257935 - Hematopoietic factor production promoter The present invention provides methods of screening for enhancers and/or inhibitors of a hematopoietic factor production promoter comprising arginine as an active ingredient. Arginine is an excellent hematopoietic factor production promoter, because it has high safety, can be orally administered, and is widely used. ... 11/16/06 - 20060257934 - Cell-based assay for the quantitative high throughput screening of gamma-aminobutyric acid-induced halide transport The present invention is directed to a rapid, quantitative screening procedure of γ-aminobutyric acid (GABA)-mediated halide transport in cells with the use of a conventional 384-well fluorescence plate reader (FLIPR). The halide sensor is a novel yellow fluorescent protein (YFP) with mutations at positions 46/148/152 that exhibits bright fluorescence at ... 11/16/06 - 20060257933 - Biosensor It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on ... 11/16/06 - 20060257932 - Treatment of crohn's disease The oral administration of a drug results in the safe and effective treatment of individuals with moderate to severe Crohn's disease. Additionally, the identification and measurement of the levels of certain markers may be used to create an immune profile for the prediction of clinical responses to the drug. These ... 11/16/06 - 20060257931 - Method of arrangement of titanium-binding ferritin and inorganic particles A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal ... 11/16/06 - 20060257930 - Characterization of il-17f and il-17r interactions The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial cells. Thus, the present invention provides isolated and purified IL-17F or IL-17R polynucleotides and polypeptides. The present invention also is directed to novel ... 11/16/06 - 20060257929 - Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins The present invention describes a method for the rapid binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate. Ligands directed to microbes are covalently attached to the substrate surface by tethers that are between 35 ... 11/16/06 - 20060257928 - Ange gene in atopy The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to ... 11/16/06 - 20060257927 - Processes for purification of recombinant proteins Processes for the detection and purification of peptides and proteins comprising a metal ion-affinity peptide having a high affinity for coordinated metals and also being highly antigenic are described. Antibodies for use in the processes are also described. ... 11/16/06 - 20060257926 - Immuno-nephelometry of lipoprotein (a) and reagent therefor Provided is a method for quantitatively measuring an antigen having diverse phenotypes with accuracy in immunoassay. The present invention is particularly intended to latex turbidimetric immunoassay using the antigen-antibody reaction of an antigen having phenotypes, wherein, in detection utilizing the immunoassay, the amount of an antibody against the antigen added ... 11/16/06 - 20060257925 - Method for isolating intracellular antibodies able to neutralize protein interactions A method is described for isolating neutralizing intracellular antibodies of an interaction between a protein ligand x and a protein ligand y inside a cell. A method to identify a protein ligand x able to bind to a known y ligand using intracellular antibodies able to disrupt the interaction between ... 11/09/06 - 20060252100 - Compositions and methods of using apoptosis signaling kinase related kinase (askrk) The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes ... 11/09/06 - 20060252099 - Method for measurement by using long-lived excitation fluorescence A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, ... 11/09/06 - 20060252098 - Isolated dna encoding cullin regulators roc1 and roc2, isolated proteins encoded by the same, and methods utilizing the same The present invention provides isolated polynucleotide sequences encoding the proteins ROC1 and ROC2, the isolated proteins themselves, expression vectors containing at least a fragment of the ROC1 and ROC2 polynucleotide sequences, and host cells comprising the same. Methods of producing the ROC1 and ROC2 proteins are also disclosed, and methods ... 11/09/06 - 20060252097 - Detection of carbohydrate biomarkers The present invention generally relates to detection of carbohydrate biomarkers in nipple aspirate fluid samples. One aspect of the invention is a method for assaying a nipple aspirate fluid for the presence of TF or Tn carbohydrate biomarker. The assay generally employs an immobilized capture agent specific for TF or ... 11/09/06 - 20060252096 - Single chain antibody with cleavable linker Disclosed are antibodies and methods for making antibodies with desired glycosylation and efficient production. Host cells transformed with a nucleic acid encoding a fusion protein comprising a signal sequence, light and heavy immunoglobulin chains, each comprising a variable region and a constant region and separated by a spacer peptide comprising ... 11/09/06 - 20060252095 - Aerosol particle analyzer for measuring the amount of analyte in airborne particles Aerosol particle analyzer (APA) for measuring the amount of analyte in airborne particle is described. The APA uses an analysis liquid. In most embodiments, this analysis liquid is chosen so that when it is mixed with the particles, an optical property of the analysis liquid (AL) varies according to the ... 11/09/06 - 20060252094 - Selfassembled grafted polymeric layer for use in biosensor technology wherein A is selected from the group consisting of hydrogen, methyl, methoxy and functional polyethylene glycol based chains, B is a functional group for binding biologically-sensitive materials, D is a functional group for binding to a substrate, m is from 3 to 5, v is from 0 to 5, w ... 11/09/06 - 20060252093 - Heterocyclic organic molecules through intramolecular formation of n-acyliminium ions The present invention relates to a method of preparing heterocyclic organic com-pounds involving intramolecular formation of an N-acyliminium ion and an in-tramolecular Pictet-Spengler reaction. The invention furthermore discloses precursor molecules useful for the method and methods of preparing these precursor mole-cules. The invention also relates to heterocyclic organic compounds prepared ... 11/02/06 - 20060246515 - High throughput generation and affinity maturation of humanized antibody Compositions, methods, and kits are provided for efficiently generating and screening humanized antibody with high affinity against a specific antigen. The library of humanized antibody is generated by mutagenizing a chimeric antibody template that combines human antibody framework and antigen binding sites of a non-human antibody. Alternatively, the library of ... 11/02/06 - 20060246514 - Mass spectrometric immunoassay Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass ... 11/02/06 - 20060246513 - Method and device to detect the presence of analytes in a sample Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatagraphic test strip. ... 11/02/06 - 20060246512 - Biosensor It is an object of the present invention to provide a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The present invention provides a biosensor which comprises a substrate having at least two types of surfaces on a single ... 11/02/06 - 20060246511 - Methods of determining levels of steroid fractions utilizing shbg calculations There are provided methods for assaying biological specimens for steroids (androgens and estrogens), Sex Hormone-Binding Globulin (SHBG) and Albumin in order to calculate the free and bioavailable steroid concentration based on the laws of mass action and association constants predicated on the identification that one molar equivalent of SHBG contains ... 11/02/06 - 20060246510 - Sensing element for a biosensor A sensing element for use in a biosensor comprises a matrix of discrete particles formed from a material capable of supporting surface electromagnetic waves, the particles having a biologically active molecule bound thereto. ... 11/02/06 - 20060246509 - Unnatural reactive amino acid genetic code additions This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are ... 11/02/06 - 20060246508 - Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same The invention provides a biologically active substance transfer sheet which can be formed with simple steps, a cell culture kit which comprises a cell culture plate and a biologically active substance transfer sheet, a producing method therefor, and a method for screening cell culture conditions with cells. The transfer sheet ... 11/02/06 - 20060246507 - Beta-arrestin based screening assays Use of mutated β-arrestin for an improved enzyme complementation assay or translocation assay, the improved enzyme complementation assay comprising: i) adding a substrate to a cell comprising a GPCR-EA fusion protein and a β-arrestin-EB fusion protein, wherein the β-arrestin is mutated, ii) adding a ligand to obtain, if possible, a ... 11/02/06 - 20060246506 - Non-competitive immunoassay for small analytes A non-competitive immunoassay for small analytes, wherein the analyte is reacted with two binding partners. The first binding partner binds to the analyte to form a complex between the first binding partner and the analyte, and the second binding partner binds to the complex formed by the first binding partner ... 11/02/06 - 20060246505 - Modulation of the synthesis of insulin The invention particularly relates to the use of substances, which modulate the activity of the proteins casein kinase II (CK II) and 14-3-3 epsilon and/or of the PcG protein EED or which influence the binding of the proteins casein kinase II (CK II) and 14-3-3 epsilon, of the PcG protein ... 10/26/06 - 20060240482 - Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic ... 10/26/06 - 20060240481 - Melanocortin metallopeptode combinatorial libraries and applications Melanocortin receptor-specific peptide combinatorial libraries for forming metallopeptides and metallopeptide combinatorial libraries are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are constructed of peptides constructed from naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically ... 10/26/06 - 20060240480 - Use of gfap for identification of intracerebral hemorrhage The present invention relates to the use of glial fibrillary acidic protein (GFAP) as a diagnostic marker for intracerebral hemorrhage. The invention especially relates to methods for the early detection of intracerebral hemorrhage. Such early and rapid detection can be performed rapidly e.g. by a test strip format assay. GFAP ... 10/26/06 - 20060240479 - Fluorescent label The present invention relates to a fluorescent label characterized by containing a hydrophilic polymer having an anionic group, a polyether derivative, and a phosphor, in which the phosphor is bound to the hydrophilic polymer via the polyether derivative, and also relates to a fluorescently labeled recognition substance labeled with the ... 10/26/06 - 20060240478 - Biosensor One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on ... 10/26/06 - 20060240477 - Method for the production of near net-shaped metallic and/or ceramic parts The present invention relates to a peptide comprising a symmetrical dimethylated arginine, and constitute an immunologic determinant of antibodies present in sera from patients with systemic lupus erythematosus (SLE), and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said ... 10/26/06 - 20060240476 - Construct comprising recognition domain of antibody against von willebrand factor-specific cleaving enzyme The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also ... 10/26/06 - 20060240475 - Diagnostic method for celiac sprue Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. ... 10/26/06 - 20060240474 - Peptides able to switch between two structural states and their use The present invention relates to peptides that switch between 2 structural states in response to the presence or absence of a stimulus. The present invention also relates to the use of the peptides of the present invention in an assay to detect the presence or absence of a stimulus. The ... 10/26/06 - 20060240473 - Saccharide libraries Novel methodologies for producing saccharide libraries are provided as well as the libraries themselves. ... 10/26/06 - 20060240472 - Pigment protein An object of the present invention is to provide a novel chromoprotein derived from Cnidopus japonicus. The present invention provides a chromoprotein derived from Cnidopus japonicus having the following properties: (1) the absorption maximum wavelength is 610 nm, and fluorescence is not emitted; (2) the molar absorption coefficient is 66,700 ... 10/19/06 - 20060234308 - Method for determining the substrate specificity of an enzymatic activity and a device therefor The invention relates to a method for determining the substrate specificity of an enzymatic activity comprising the following steps: providing an assembly comprising a plurality of amino acid sequences on a planar surface of a support material, whereby the amino acids are directionally immobilised; contacting and/or incubating of an enzymatic ... 10/19/06 - 20060234307 - Modified peptides as therapeutic agents The present invention concerns fusion of Fc domains with Ang-2 binding peptides and a process for preparing such molecules. In this invention, pharmacologically active compounds are prepared by a process comprising (a) selecting at least one random peptide that binds to Ang-2; and (b) preparing a pharmacologic agent comprising an ... 10/19/06 - 20060234306 - Assay method A new method for assaying the ability of a compound to block the binding of an α4 integrin to a binding partner thereof provides a useful screening tool. ... 10/19/06 - 20060234305 - Gene encoding g-protein coupled receptor and gene product thereof The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful ... 10/19/06 - 20060234304 - Diagnosis of acute myocardial, ischemic diseases A method for the diagnosis of acute myocardial, ischaemic diseases, for example acute myocardial infarct, particularly without increasing ST-paths in EKG (NSTEMI). At least two markers on a patient, who is to examined, are determined. A kit for carrying out said diagnostic method, including a test strip for carrying out ... 10/19/06 - 20060234303 - Methods for the design of libraries of protein variants Methods for designing libraries of protein variants are provided. ... 10/19/06 - 20060234302 - Libraries and methods for isolating antibodies The disclosure features methods for identifying antibodies that bind to a carbohydrate moiety. Libraries coding for antibodies that bind to a carbohydrate moiety are provided. The libraries can be provided by modifying a pre-existing nucleic acid library. Antibodies that bind to a carbohydrate moiety are described. ... 10/19/06 - 20060234301 - Method for diagnosing multiple sclerosis Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample. ... 10/19/06 - 20060234300 - Cardiac hormones for assessing cardiovascular risk The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the cardiovascular risk of a patient who is a candidate for adminitstration of a cox-2-inhibiting compound, in particular an NSAID, selective cox-2 inhibitior, or steroid. More particularly, the present invention relates to the use of ... 10/19/06 - 20060234299 - Protein scaffolds and uses thereof Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention. ... 10/19/06 - 20060234298 - Systems and methods for rapidly changing the solution environment around sensors The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying receptors. ... 10/19/06 - 20060234297 - Screening method The present invention provides a screening means for a novel therapeutic drug for arteriosclerosis capable of suppressing the progression of arteriosclerosis due to infection with Chlamydia pneumoniae. Specifically, provided is a screening method for a therapeutic substance for arteriosclerosis and/or a prophylactic/therapeutic substance for complications thereof, which comprises using cells ... 10/19/06 - 20060234296 - Method for generating high affinity antibodies The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These ... 10/19/06 - 20060234295 - Sandwich immunoassay for identifying partial proanp peptides Disclosed is an improved sandwich immunoassay for identifying partial proANP peptides in cardiac and sepsis diagnosis by using two antibodies which specifically bond to partial sequences in the mid-regional area of NT-proANP, extending from amino acid 53 to amino acid 83 of NT-proANP. ... 10/19/06 - 20060234294 - Functional domain and associated molecule of dock2 essentially required in lymphocyte migration The present invention is related to provide a method for screening a substance interfering in the association of DOCK2 and ELMO1, a method for screening a substance interfering in the association of ELMO1 and Tiam1, and a method for searching a therapeutic agent for immune related diseases such as allergy, ... 10/19/06 - 20060234293 - Polypeptide methods and means The structure of a RAD51-BRC repeat sequence complex structure is provided. The structure can be used in modelling the interaction of molecular structures such as potential pharmaceutical compounds. Mutant RAD51 and BRCA2 polypeptides and RAD51-BRC repeat sequence chimaera proteins and are also provided. The mutants may be used in assays ... 10/19/06 - 20060234292 - Methods of diagnosing and treating diabetes and insulin resistance The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels ... 10/19/06 - 20060234291 - Site selective acylation Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No. 3, SEQ. ID No. 4, SEQ. ID No. 5, or SEQ. ID No. 7, or one ... 10/12/06 - 20060228760 - Allergen detection apparatus A method of determining allergen activity in dust comprises: providing a dust sample; extracting from the dust sample at least one breakdown component or proteins or peptides; reacting the extracted at least one breakdown component with a colorimetric amine detection reagent such as TNBSA; and quantitatively measuring the intensity of ... 10/12/06 - 20060228759 - Analysis of mhc-peptide binding interactions Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC protein is provided. A first component including at least one candidate peptides and a second component including at least one MHC protein are contacted. One of the components is immobilized on a solid support. The ... 10/12/06 - 20060228758 - Analysis of mhc-peptide binding interactions Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC protein is provided. A first component including at least one candidate peptides and a second component including at least one MHC protein are contacted. One of the components is immobilized on a solid support. The ... 10/12/06 - 20060228757 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form ... 10/12/06 - 20060228756 - Relational database management system for automated random crystallization screening A relational database management system for automated random crystallization screening systems so as to provide facilitated data tracking, maintenance, and analysis. The system includes a database server module capable of storing data; an ARCS module having a crystallization screen design engine capable of generating random crystallization screens and associated crystallization ... 10/12/06 - 20060228755 - Ectopic pregnancy markers The present invention relates to methods for determining a risk or identifying a condition associated with the presence of ectopic pregnancy in a subject as well as testing a candidate compound for a therapeutic activity against an ectopic pregnancy and sorting patients based on the risk of having ectopic pregnancy. ... 10/12/06 - 20060228754 - Methods for screening compound libraries Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. Methods are also disclosed which permit a compound library to be rapidly screened to determine if any member of the ... 10/12/06 - 20060228753 - Methods of detecting a phenotype of a polymorphic protein The present invention provides an antibody that differentially reacts with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, nucleic acids encoding same, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of ... 10/05/06 - 20060223121 - Use of a polypeptide for detecting, preventing or treating a pathological condition associated with a degenerative, neurological or autoimmune disease The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide ... 10/05/06 - 20060223120 - High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins Herein is described and optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization ... 10/05/06 - 20060223119 - Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism The present invention relates to kits for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism. The kit provides means to measure the level of a PTH agonist and a PTH antagonist in a patient, and it further provides means for administering a PTH suppressing ... 10/05/06 - 20060223118 - Screening of chemical compounds purified from biological sources A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality ... 10/05/06 - 20060223117 - Novel splice variants of human epithelial sodium channel genes expressed in human taste tissue and uses thereof Nucleic acid sequences encoding novel splice variants that encode subunits of an ENaC expressed in human taste tissue are provided. These splice variants when expressed in association with other ENaC subunits, i.e., α, β and γ subunits or α, β and Δ subunits may be used to produce amiloride-insensitive ENACs. ... 10/05/06 - 20060223116 - Modulation of th2 lineage commitment by t-bet The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase-mediated interaction of T-bet with GATA-3, as well as methods of use therefore. ... 10/05/06 - 20060223115 - Heterotrimeric g-protein Receptor mediated activation of heterotrimeric G-proteins is visualized in living cells by monitoring fluorescence resonance energy transfer (FRET) between subunits of a G protein fused to cyan and yellow fluorescent proteins. The G-protein heterotrimer rapidly dissociates and reassociates upon addition and removal of cognate ligand. Energy transfer pairs of G-proteins ... 10/05/06 - 20060223114 - Protein scaffolds and uses thereof The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention. ... 10/05/06 - 20060223113 - Immobilization of binding agents A method of preparing an array of discrete localized binding agent-supporting regions on a solid support surface as well as an array prepared by the method are disclosed. The method comprises: providing a solid support bearing functional groups at a plurality of predefined discrete regions and being in a first ... 10/05/06 - 20060223112 - Novel receptor The present invention relates to the novel GABAB receptor subtypes GABAB-R1c and GABAB-R2 as well as to a novel, functional GABAB receptor which comprises a heterodimer of GABAB-R1 and GABAB-R2 receptor subunits. The present invention also relates to variants of the receptors, nucleotide sequences encoding the receptors and variants thereof ... 10/05/06 - 20060223111 - Biosensor system that enables spectral multiplexing A biosensor includes at least two sensors having different resonant frequencies. The different resonant frequencies of the sensors can be achieved by fabricating the sensors with different spatial profiles of regions of high and low dielectric constant. Because the sensors have different resonant frequencies, they can be monitored in parallel ... 10/05/06 - 20060223110 - Compositions and methods involving nuclear hormone receptor site ii A binding site in nuclear hormone receptors is described and its structural coordinates are provided. The invention provides machine-readable data storage media comprising structure coordinates of Site II and computer systems comprising the machine-readable data storage media. The invention provides methods used in the design and identification of ligands of ... 09/28/06 - 20060216755 - Il1rl-1 as a cardiovascular disease marker and therapeutic target This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure. ... 09/28/06 - 20060216754 - Process for the preparation of ring compounds In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses ... 09/28/06 - 20060216753 - Binding proteins as biosensors The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo. ... 09/28/06 - 20060216752 - Binding protein as biosensors The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo. ... 09/28/06 - 20060216751 - Method for purifying proteins The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the ... 09/28/06 - 20060216750 - New lipid binding protein 1 New Lipid Binding Protein 1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing New Lipid Binding Protein 1 polypeptides and polynucleotides in diagnostic assays. ... 09/28/06 - 20060216749 - Chimeric gaba receptor In a particular embodiment the present invention provides the use of the aforementioned GABAB receptor in a method to identify a high affinity GABAB receptor agonist using a functional or a binding assay. In particular in a radioligand-binding assay comprising the use of radiolabeled agonists such as for example 3H-GABA ... 09/21/06 - 20060211050 - Methods of using 18903 to treat pain and pain-related disorders The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which ... 09/21/06 - 20060211049 - Estrogen related receptor, erralpha, a regulator of bone formation Methods and pharmaceutical compositions are provided for modulating bone formation in a mammal. Methods are also provided for screening compounds for their efficacy as modulators of bone formation. ... 09/21/06 - 20060211048 - Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 09/21/06 - 20060211047 - Test kit It is an object of the present invention to significantly improve the treatment efficiency of bronchial asthma by intervening with inhaled steroids or the like and discontinuing the intervention at the most appropriate times respectively on the basis of accurately and objectively grasping the pathologic condition of an asthma patient ... 09/21/06 - 20060211046 - Bacterial ligand-binding sensor The invention relates to fusion proteins and bacteria encoding them. The fusion proteins include a ligand-binding domain interposed between the splicing domains of an intein. An auxotroph-relieving protein domain is fused to one of the splicing domains so that the auxotroph-relieving function of the domain is activated upon ligand binding. ... 09/21/06 - 20060211045 - Fluorescently tagged ligands characterised in that linking is at same or different linking sites in compounds comprising different Lig, JL, L JT and/or -Tag and is at different linking sites in compounds comprising same Lig, JL, L JT and/or -Tag; process for the preparation thereof; process for the preparation of a library compound ... 09/21/06 - 20060211044 - Translucent solid matrix assay device dor microarray analysis The present invention concerns methods and compositions relating to translucent matrix arrays. In certain embodiments, the arrays are reconfigurable. Reconfigurable arrays may be produced using small linker molecules, such as aptamers or affibodies, which preferably bind to an IgG specific portion of antibodies. Such arrays may be used to detect ... 09/21/06 - 20060211043 - Molting hormone receptor and method for screening ligand to the receptor The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting hormone receptor comprising the following polypeptide (a) and polypeptide (b) or (c): (a) a polypeptide having the amino acid ... 09/21/06 - 20060211042 - Methods of identifying modulators of cellular glycosylation using gtrap3-18 The present invention provides methods and compositions for identifying compounds which modulate cellular glycosylation. The invention further provides methods for treating subjects suffering from or at risk of developing a glycosylation associated disorder. ... 09/21/06 - 20060211041 - Protein binding to akt2 A novel polypeptide useful in screening an insulin resistance improving agent and a carbohydrate metabolism improving agent, a polynucleotide coding for the aforementioned polypeptide, an expression vector comprising the aforementioned polynucleotide, and a cell transfected with the aforementioned expression vector are disclosed. The aforementioned polypeptide is a protein which is ... 09/21/06 - 20060211040 - Crystal structure of chorismate synthase and uses thereof The invention describes the identification of the structure coordinates for the enzyme Chorismate Synthase. There is a computer programmed to produce a three-dimensional representation of a molecule or molecular complex, wherein the molecule or molecular complex comprises a binding domain defined by the structure coordinates of (a) Arg 39, His ... 09/14/06 - 20060205019 - Methods and compositions for directed gene assembly The present invention is directed to methods and compositions for use of homologous recombination for directed evolution, gene reassembly, and directed mutagenesis. One aspect of the present invention relates to methods for use of bacterial conjugative transfer and homologous recombination for directed evolution, gene reassembly, and directed mutagenesis. Another aspect ... 09/14/06 - 20060205018 - Novel human enzymes of the metalloprotease family This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, and to production of such polypeptides and ... 09/14/06 - 20060205017 - Microorganism genomics, compositions and methods related thereto The present invention provides methods and compositions for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways. ... 09/14/06 - 20060205016 - Protein a based binding domains with desirable activities Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural variable heavy chain III (“VH3”) Ig-Fab binding region (“binding region”) of SpA, wherein the polypeptide exhibits a different binding specificity ... 09/14/06 - 20060205015 - Method for detecting the interactions between a g protein-coupled receptor (gpcr) and one of the galpha or gbetagamma subunits The present invention relates to a method for the detection of ligands (agonists or antagonists) specific for a G protein-coupled receptor (GPCR), which comprises the steps consisting in: 1) bringing a receptor labelled with a member of a donor/acceptor pair into contact with a Gα or Gβγ subunit of a ... 09/14/06 - 20060205014 - Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample. ... 09/14/06 - 20060205013 - Fet-type biosensor with surface modification Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect ... 09/14/06 - 20060205012 - Diagnostic test Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the ... 09/14/06 - 20060205011 - Combinatorial artificial receptors including tether building blocks on scaffolds The present invention relates to artificial receptors on scaffolds, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds coupled to a scaffold. In an embodiment, at least one of the building blocks includes a tether moiety. The ... 09/14/06 - 20060205010 - Methods of host cell protein analysis The invention provides methods of determining the presence of host cell proteins in sample. The invention further provides methods of following the purification of target proteins. Kits and articles of manufacture are also provided. ... 09/14/06 - 20060205009 - Methods of assessing endothelial dysfunction using acute transient responese following fat administration The present invention provides methods utilizing the fat-induced antibody response (FIAR) to assess endothelial function. Additional methods are provided that utilize FIAR for diagnosing and monitoring the progression of vascular diseases, the success of treatment for these diseases, and as a measure of the oxidative stress imposed upon vascular endothelium. ... 09/07/06 - 20060199226 - Functional bioluminescence energy resonance transfer (bret) assay to screen, identify and characterize receptor tyrosine kinase ligands Disclosed herein are methods of evaluating whether a test compound functions as a ligand for a receptor tyrosine kinase. Also provided are methods of making pharmaceutical compositions that include agonists, antagonists, or inverse agonists of receptor tyrosine kinases. Also provides are isolated cells that include a receptor tyrosine kinase and ... 09/07/06 - 20060199225 - Modified chitin binding domain and uses thereof Compositions and methods are provided for reversibly binding chitin-binding domain (CBD) to a chitin or equivalent substrate under non-denaturing conditions. CBD from either prokaryotes or eukaryotes are modified for example, by random mutation, and screened to identify mutants that achieve this change in properties. Creating a modified CBD with an ... 09/07/06 - 20060199224 - Parallel identification of antibacterial targets and inhibitors The invention relates to methods for the parallel identification of compounds that have antibacterial activity as well as the target gene for that compound. This approach allows for coupled target validation/drug discovery, elucidation of mechanism(s) of antibacterial agents as well as discovery of new antibacterial pharmacophores having the same mechanism ... 09/07/06 - 20060199223 - Chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays. ... 09/07/06 - 20060199222 - Bacillus transformation, transformants and mutant libraries The present invention provides methods for building DNA constructs in vitro, transforming such constructs into competent Bacillus strains with good efficiency, and generating populations of mutants. Also provided is a method to assemble DNA constructs in situ. ... 09/07/06 - 20060199221 - Correction for temperature dependence assays The present invention provides a method to calibrate an assay for variations or fluctuations in an assay parameter such as, but not limited to, temperature that affect the measured assay signal and thereby to calculate an analyte concentration with improved accuracy. The method is preferably performed in a manner such ... 09/07/06 - 20060199220 - Protein arrays and uses thereof The Inventors herein describe methods for the production of a functional human, animal, plant or microbe protein arrays and methods to assay for interactions between the proteins on the array with molecules of interest, for example, using such arrays to determine the in vitro metabolite profile of any drug. Such ... 09/07/06 - 20060199219 - Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands The present invention relates to screening methods and, in particular, to methods of screening anti-ligands libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount ... 08/31/06 - 20060194258 - Polypeptide array synthesis The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources. ... 08/31/06 - 20060194257 - Mecp2e1 gene The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders. ... 08/31/06 - 20060194256 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have ... 08/31/06 - 20060194255 - Parallel patch clamp system A system for high-throughput analysis of membranous samples having ion channels including at least one membranous sample, a multi-compartment structure including an extracellular chamber, an opposing intracellular chamber and a partition separating the extracellular and intracellular chambers, the partition having a plurality of apertures fluidly and electrically coupling the extracellular ... 08/31/06 - 20060194254 - Method for identifying optimal binding ligands to a receptor The present invention provides a method for determining binding of a receptor to one or more ligands. The method consists of contacting a collective receptor variant population with one or more ligands and detecting binding of one or more ligands to the collective receptor variant population. The collective receptor variant ... 08/31/06 - 20060194253 - A transfected cell line and a method using the same for the high throughput screening for inhibitors of the t-type calcium channel alpha-1h The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type α1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is ... 08/31/06 - 20060194252 - Nanoscale patterning and immobilization of bio-molecules A support for immobilizing target molecules comprises a substrate having a plurality of binding regions for binding select target molecules, with target-molecule-capturing agent immobilized at the binding regions. The binding regions are intersperse among other non-binding regions. The binding regions are of sub-micron size, have high selectivity and high binding ... 08/31/06 - 20060194251 - Method of fixing low-molecular compound to solid-phase support A method of fixing a low-molecular compound to a solid-phase support, which comprises a step in which a solution containing a low-molecular compound is brought into contact with a solid-phase support having a photoreactive compound bonded to the surface, a step in which the solution containing a low-molecular compound is ... 08/24/06 - 20060188943 - Color-encoding and in-situ interrogation of matrix-coupled chemical compounds A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial ... 08/24/06 - 20060188942 - Detection of micro-organisms The present invention concerns methods for detecting the presence of a micro-organism in a fluid, gaseous and solid samples, together with apparatus for use in same. The invention comprises the use of a plurality of hollow fibres to filter the fluid and the capture of the micro-organisms on the membrane ... 08/24/06 - 20060188941 - High throughput screening assays utilizing affinity binding of green fluorescent protein Novel methods of detecting fluorescent proteins are described. The methods result in vastly improved signal-to-noise ratios in assays measuring fluorescence of a fluorescent protein specifically by employing a unique trapping step to microconcentrate the fluorescent protein and by using improved optical techniques. The trapping step may be a chemical or ... 08/24/06 - 20060188940 - Combinatorial hydrogel formulation The present invention concerns a method, apparatus (array assembly), and system for fabricating and formulating hydrogels using combinatorial techniques; a hydrogel array fabricated using the method, apparatus, and/or system of the invention; and methods and systems for testing the properties of arrayed hydrogels, such as bulk and interfacial mechanical properties. ... 08/24/06 - 20060188939 - Fecal sample test device and methods of use The present invention includes devices and methods for the detection of an analyte in a fecal sample. The fecal sample test device includes a sample collection structure and sample collection housing, a detection housing, a fecal suspension solution or fecal dilution solution, a detection housing capable of attachment to the ... 08/24/06 - 20060188938 - Compounds for inhibiting beta-amyloid production and methods of identifying the compounds Provided are compounds useful for treating diseases associated with a cerebral accumulation of Alzheimer's amyloid, such as Alzheimer's disease. Also provided are methods for screening for such compounds, by measuring capacitative calcium entry in cells which optionally overexpress APP or a fragment thereof. Also provided are methods of treating or ... 08/24/06 - 20060188937 - G-protein estrogen membrane receptor The present invention includes compositions and methods for the identification, isolation and characterization of a G-protein-coupled receptor that binds to an estrogen or estrogen-like molecule, to modulators of the receptor's activity and diagnostic methods for use in detection and treatment of a G-protein-coupled receptor related cancer. ... 08/24/06 - 20060188936 - Alzheimer's related proteins and methods of use Disclosed is a method for identifying substances that alter the interaction of a presenilin protein with a presenilin-binding protein, including contacting at least the interacting domain of a presenilin protein to a presenilin-binding protein in the presence of a test substance, and measuring the interaction of the presenilin protein and ... 08/24/06 - 20060188935 - Protein and its use in diagnosing alzheimer's disease Embodiments are directed to a peptide and protein containing that peptide, nucleic acids, antibodies, as well assays detecting the peptide or protein, and methods of identifying patients with or at risk of developing Alzheimer's Disease and other neurodegenerative diseases. ... 08/24/06 - 20060188934 - System and method for implementing a high-sensitivity sensor with improved stability A high-sensitivity sensor with improved stability includes nanostructure-based sensors that are arranged such that a first nanostructure-based sensor (“shielded sensor”) is shielded from potential exposure to an environmental factor of interest and a second nanostructure-based sensor (“exposed sensor”) is allowed potential exposure to an environmental factor of interest. Further, all ... 08/24/06 - 20060188933 - Irak-m is a negative regulator of toll-like receptor signaling Isolated nucleic acid encoding the amino acid sequence of murine IRAK-M; expression vectors comprising nucleic acid encoding IRAK-M and host cells comprising them are disclosed. IRAK-M is induced upon toll-like receptor (TLR) stimulation and negatively regulates TLR signaling. Methods for identifying antagonists and agonists of IRAK-M are described. ... 08/24/06 - 20060188932 - Particle having magnetic material incorporated therein, process for producing the same, particle for immunoaasay and method of immunoassay It is an object of the present invention to provide magnetic substance-encapsulated particles which have uniform magnetism, high dispersion stability and a narrow particle size distribution, a method of producing the same, particles for immunoassay formed by using the magnetic substance-encapsulated particles and a method of immunoassay in which the ... 08/24/06 - 20060188931 - Method of preparing affinity ligands The present invention is a method of preparing affinity ligands, which method comprises to provide a cyclic scaffold comprising a thiol group, a carbonyl group and an amine group; to derivatise the amine group of said scaffold with an electrophile that carries either a functionality capable of affinity interaction or ... 08/24/06 - 20060188930 - Isolated fluorescent protein from clytia gregaria cgfp and use thereof The invention relates to the nucleotide and amino acid sequences and to the activity and use of the fluorescent protein CGFP. ... 08/24/06 - 20060188929 - Method capable of being automated for detection of prpres and uses thereof This detection method uses a solid support whereon plasminogen is immobilized, and includes essentially the following steps: (a) preparing the biological sample during which the latter is incubated on a homogenizing buffer which comprises an ionic or nonionic surfactant, a glucose-containing buffer, a saccharose-based buffer and a PBS buffer or ... 08/17/06 - 20060183160 - Novel beta-secretase and modulation of beta-secretase activity The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell ... 08/17/06 - 20060183159 - Method for engineering a protein by in vitro coevolution The present invention relates to compositions and methods for generating proteins with novel functions. The methods employ an in vitro coevolution approach that, in a stepwise manner, generates one or more intermediate functions. A pathway containing one or more analog molecules corresponding to the intermediate functions, and a target molecule, ... 08/17/06 - 20060183158 - Novel gene and use thereof A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or ... 08/17/06 - 20060183157 - Methods and devices for characterizing macromolecular complexes using isotope labeling techniques A method for characterizing interactions in macromolecular complexes, such as protein-protein or protein-ligand complexes, by selective isotopic labeling of the target molecule to reduce the 1H density in a selected spectral region; by irradiating the target; and by monitoring the polarization using filtered nuclear Overhauser spectroscopy (NOESY) and/or by performing ... 08/17/06 - 20060183156 - Prpsc-selective peptides The present invention features methods for identifying peptides that selectively bind to PrPSc or fragments thereof. The invention also features the use of such peptides in screening methods for the identification of candidate agents useful for the treatment of a prion disease. ... 08/17/06 - 20060183155 - Compound libraries by glycotransferases and a method of preparing the same The present invention aims to provide processes for rapidly and easily preparing compound libraries of known structures, and compound libraries prepared by said processes. A compound library of the present invention is prepared by a process for preparing a compound library in the same vessel, comprising: (1) mixing one or ... 08/17/06 - 20060183154 - Human ring specific bnp antibodies The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample. ... 08/17/06 - 20060183153 - Method for screening substances capable of promoting oligomerization of receptor protein molecules The present invention provides a method for screening substances that promote oligomerization of receptor protein molecules or peptide fragments thereof, which comprises determining whether the receptor protein molecules or peptide fragments thereof are oligomerized when contacted with a test substance; a test kit for screening substances that promote the oligomerization ... 08/10/06 - 20060177874 - Sensing switch and detecting method using the same Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region ... 08/10/06 - 20060177873 - Method of adjusting the working range of a multi-analyte assay The invention features a method of adjusting the concentration of at least one but not all of a plurality of analytes in a fluid sample to match a known working range of detection of an analyte assay system, where each of the plurality of analytes may or may not be ... 08/10/06 - 20060177872 - Diagnostic test for vitamin b12 An isolated nucleotide sequence or fragment thereof encoding the porcine intrinsic factor, wherein the porcine intrinsic factor comprises an amino acid sequence having at least 85% amino acid sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 6, and ... 08/10/06 - 20060177871 - Murine il-18 crystal structure A novel murine IL-18 native crystalline structure is identified. ... 08/10/06 - 20060177870 - Immunoassays Methods for discriminating between related proteins and other analytes in a sample and for correlating protein expression with disease states. ... 08/10/06 - 20060177869 - Analysis of compounds The analysis of compounds utilising the physical response of cellular networks is described. Typically, the electrical characteristics of the cellular network are monitored although other characteristics such as fluorescence may be monitored. In any event, the analysis utilises signal processing techniques to derive a set of features which may be ... 08/03/06 - 20060172343 - Novel vegf-like factors A novel human gene having a significant homology with a VEGF-C gene, a member of the VEGF family, has been isolated by the PCR method using primers designed based on the sequence of EST that is assumed to be homologous with the C-termial region of the VEGF-C gene. Mouse and ... 08/03/06 - 20060172342 - Antibody assay methods to assess risk for tia/stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, and optionally measuring other biomarkers such as homocysteine and glutamate. The ... 08/03/06 - 20060172341 - Assay methods for immediate diagnosis of cause of stroke A methods, kits and, compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, and optionally measuring other biomarkers such as homocysteine and glutamate. The ... 08/03/06 - 20060172340 - Multi-array, multi-specific electrochemiluminescence testing Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of ... 08/03/06 - 20060172339 - Particle-based multiplex assay for identifying glycosylation The present invention provides systems, methods and kits for performing multiplexed assays for glycoproteins using encoded particles as supports for glycoprotein specific binding agents. ... 08/03/06 - 20060172338 - Method for diagnosing multiple sclerosis Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample. ... 08/03/06 - 20060172337 - Screening molecules with anti-prion activity: kits, methods and screened molecules The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the adel-14 allele of the ADE1 ... 07/27/06 - 20060166280 - Labor biomarkers, methods comprising same, and methods targeting same The present invention provides methods of predicting or detecting labor in a female subject and methods of testing a compound for an ability to delay the onset of labor. The present invention also provides methods of testing a labor marker useful in the diagnostic methods, isolated peptides identified in the ... 07/27/06 - 20060166279 - Sea-trosy and related methods A method for preferentially observing an exposed position (1c) of a macromolecule. A sample is obtained having a macromolecule (1a) with a first proton (1) and a second molecule (2a) with a second proton (2); then applying a magnetic field (4) to the sample and irradiating the sample with a ... 07/27/06 - 20060166278 - Method for synthesizing sugar chain(s) An object of the present invention is to provide a method for efficiently chemically synthesizing biomolecules including a nucleotide (nucleic acid), a peptide (protein), or a sugar chain, as representative examples. The present invention provides a method of solid-phase synthesis of sugar chain(s) for synthesizing multiple types of sugar chains ... 07/27/06 - 20060166277 - Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C, angiogenin, beta fertilin, hypothetical protein, leukocyte associated Ig-like receptor secreted protein, erythroid ... 07/27/06 - 20060166276 - Method of diagnosis and agents useful for same The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of heart failure in a mammal and, more particularly, to a method of diagnosing, predicting or monitoring the development or progress of congestive heart failure in a mammal. The present invention contemplates a ... 07/27/06 - 20060166275 - Amyloid beta protein (globular assembly and uses thereof) The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid β peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein ... 07/27/06 - 20060166274 - G protein coupled receptor (gpcr) agonists and antagonists and methods of activating and inhibiting gpcr using the same The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same. ... 07/27/06 - 20060166273 - Enhanced methods for crystallographic structure determination employing hydrogen exchange analysis The present invention provides methods for crystallographic structure determination employing hydrogen exchange analysis. Hydrogen exchange analysis is used to identify unstructured regions of a protein, and then hydrogen exchange analysis repeated after the protein is admixed with candidate agents and/or conditions that may induce structure in said identified unstructured regions. ... 07/27/06 - 20060166272 - Method of adjudicating on acute aortic dissection and reagent for adjudication A method of evaluating acute aortic dissection, which comprises measuring a D-dimer concentration in blood separated from a human, and determining whether or not acute aortic dissection (Stanford type A or Stanford type B) has developed, on the, basis of the measured concentration, a reagent for evaluating performing the evaluation ... 07/27/06 - 20060166271 - Non-radioactive schilling test The present invention relates to a new method named the COBASORB test, which can be used for testing the cause of cobalamin malabsorption in humans. The COBASORB test contains three separate tests (first, second and third test) that can be performed separately, sequentially or in random order and number. The ... 07/27/06 - 20060166270 - Detection of demyelination The present invention relates to a method for the detection of demyelinization in a mammal, comprising providing an NMR spectrum of metabolites in a body fluid of an individual of said mammal in which demyelinization is suspected and comparing said NMR spectrum with a difference profile, comprising a plurality of ... 07/27/06 - 20060166269 - Method of measuring binding site on plasma protein of plasma protein-binding drug and method of measuring plasma protein mutation The present invention relates to a method for readily determining the binding site on plasma protein and binding displacement effect of a drug having binding affinity to plasma protein, and application of the method to clinical diagnosis. That is to say, the present invention provides a method for determining the ... 07/27/06 - 20060166268 - Diagnosis of glaucoma by complex autoantibody repertoires in body fluids The invention relates to a method for the diagnosis of glaucoma based on the composition of autoantibodies against ocular antigens in body fluids of individuals. The method is characterized in that in a first step, autoantibodies against retinal and/or optic nerve head antigens are detected and measured in body fluids ... 07/27/06 - 20060166267 - Method for extracting proteins The present invention relates to a method and a kit for the sequential extraction of proteins for the production of partial proteomes from a complete proteome. In particular, the method according to the invention, besides other partial proteomes, gives a partial proteome of proteins from the cell nucleus interior separated ... 07/27/06 - 20060166266 - Screening method for regulatory enzymes employing tribrid (tri-hybrid) system A method for screening regulatory enzymes is described. The method involves the use of a tribrid cell engineered to express a DNA library. ... 07/20/06 - 20060160145 - Epf receptor assays, compounds and therapeutic compositions The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. ... 07/20/06 - 20060160144 - Sensor arrangement, device and method for testing active substances and/or active sites from a pharmacological point of view using an amperometer and/or potentiometer The invention relates to a sensor electrode device (20) for carrying out amperometric and/or potentiometric testing of active sites or substances from a pharmacological point of view. In order to carry out testing in a reliable, quick and inexpensive manner, the device is provided with a solid-supported electrode area (21) ... 07/20/06 - 20060160143 - Mitogenic oxygenases The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and ... 07/20/06 - 20060160142 - Phosophoinositoglycan binding proteins The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade. ... 07/20/06 - 20060160141 - Peptide sequence tags and method of using same Peptide sequence tags are identified and used to produce a class of global antibodies, which recognize all members of PsbB protein family with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to the stable PsbB protein of the Photosystem II complex catalyzing photochemical ... 07/20/06 - 20060160140 - Human nuclear receptor protein nnr7-1 The present invention discloses the isolation and characterization of cDNA molecules encoding a novel member to the human nuclear receptor superfamiliy, designated nNR7 and/or nNR7-1. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of nNR7 and/or nNR7-1 activity, and production ... 07/20/06 - 20060160139 - Rhesus bcrp and antibodies thereto The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and uses thereof, particularly as a hematopoietic stem cell marker. ... 07/20/06 - 20060160138 - Compositions and methods for protein design In certain aspects the present invention provides methods and compositions related to rational protein design. ... 07/20/06 - 20060160137 - Method for modification of a synthetically generated assay using measured whole crude properties The present invention is a method for modifying any synthetically generated assay of a whole crude oil or a portion of a whole crude, such as a condensate or resid material, by using measured crude properties. These measured properties are used to adjust the synthesized assay values to obtain a ... 07/20/06 - 20060160136 - High throughput screening of catalysts using spin resonance High throughput screening of catalyst libraries may be performed using spin resonance techniques, and an evanescent wave probe developed by the present inventors. The probe may operate using either nuclear magnetic resonance or electron spin resonance techniques. In one configuration, a scanning evanescent wave spin resonance probe is used in ... 07/20/06 - 20060160135 - Sf-1 and lrh-1 modulator development Structures of SF1 and LRH are described, along with methods for identifying or developing modulators of those receptors and uses for such modulators. ... 07/20/06 - 20060160134 - Novel application of biosensors for diagnosis and treatment of disease A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with signaling agents or nanotechnology to provide an effective and efficient method for diagnosing a condition ... 07/20/06 - 20060160133 - Glucose-transport related genes, polypeptides, and methods of use thereof Methods and compositions for modulating glucose transport are provided herein. ... 07/20/06 - 20060160132 - Diagnositics and therapeutics for diseases associated with g-protein coupled receptor hm74a (hm74a) The invention provides a human HM74a which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, urological diseases, respiratory diseases and gastroen-terological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders ... 07/20/06 - 20060160131 - Method for the identification of drug targets The present invention relates to the field of drug development. More specifically the invention provides a method for the identification of drug targets. The method can also be used for analysis of proteomes. The method utilizes in essence a combination of two chromatographic separations of the same type, separated by ... 07/13/06 - 20060154305 - Combinatorial synthesis of ceramic materials A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing ... 07/13/06 - 20060154304 - Clinical applications of crystalline diamond particles A method for profiling proteins in a biological sample by mixing the sample and a diamond-based composition. The diamond-based composition includes a diamond crystallite having a surface that contains chemically derivatized surface groups and a polymer having a plurality of functional groups non-covalently bound to the surface groups. Proteins in ... 07/13/06 - 20060154303 - Evanescent wave excited fluorescence detection method In the case where many interactional substances are immobilized on the front surface side of a light transmitting plate capable of generating evanescent waves on the front surface, and where the fluorescence levels in the interactions between the interactional substances and a fluorescence labeled test substance are detected in a ... 07/13/06 - 20060154302 - Iterative, subtractive immunoaffinity method for proteome analyte enrichment An immunoaffinity method according an embodiment of the present invention is described for selectably removing highly abundant proteins (HAP) from a sample which contains a mixture of HAP and lower abundance proteins (LAP). One method includes providing a sample having a concentration of original HAP and LAP therein and producing ... 07/13/06 - 20060154301 - Test kit for immunochromatography A test kit for immunochromatography comprising a test strip and a test tube is described. The test strip comprises a detection zone for detecting an analyte in a sample. The test tube accommodates the test strip. The test tube comprises an indicator at a position corresponding to the detection zone ... 07/13/06 - 20060154300 - Biomolecule bonding detection apparatus using wireless antenna and method thereof Disclosed is a biomolecule binding detection apparatus and a method thereof, which detects biomolecule bonding by measuring change in characteristics of a test signal transmitted by an antenna on which probe biomolecules are immobilized. The biomolecule bonding detection apparatus includes a transmitting unit on which probe biomolecules are immobilized, the ... 07/13/06 - 20060154299 - Protein microarray device having internal calibrators and methods of using therefor The present invention relates to protein microarray devices having an internal calibrator, kits containing such devices, and methods of using such devices. Such a device comprises a plurality of protein arraying pads on a support substrate, a plurality of protein arraying spots on each pad, and a calibrator disposed on ... 07/13/06 - 20060154298 - Method of synthesis and testing of combinatorial libraries using microcapsules The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary ... 07/13/06 - 20060154297 - Marker substances and the use of the same in diagnostic methods The invention relates to a diagnostic method and to marker substances which enable manipulations in endogenic marking to be detected and thus prevented. According to the invention, a metabolisable substance is added to non-metabolisable marker substances, said metabolisable substance revealing a manipulation when detected in excreta. ... 07/13/06 - 20060154296 - Pigment protein An object of the present invention is to provide a novel chromoprotein derived from Cnidopus japonicus. The present invention provides a chromoprotein derived from Cnidopus japonicus having the following properties: (1) the absorption maximum wavelength is 559 nm and the fluorescence maximum wavelength is of 578 nm; (2) the molar ... 07/06/06 - 20060148005 - Biologically active synthetic thyrotropin and cloned gene for producing same Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described. ... 07/06/06 - 20060148004 - Peptide sequence tags and method of using same Peptide sequence tags are identified and used to produce a class of global antibodies, which recognize all members of key protein subunit families for the PSI complex with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to the key PsaC or PsaA proteins ... 07/06/06 - 20060148003 - Peptide sequence tags and method of using same Peptide sequence tags are identified and used to produce a class of global antibodies, which recognize key protein subunits of the ATP Synthase complex with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to the major AtpB subunit or the AtpC subunit of ... 07/06/06 - 20060148002 - Methods and compositions for the treatment and diagnosis of body weight disorders The invention relates to methods and compositions for the treatment and diagnosis of body weight disorders, including, but not limited to, obesity, overweight, anorexia, cachexia, insulin resistance, and diabetes. The invention further provides methods for identifying a compound capable of treating a body weight disorder. In addition, the invention provides ... 07/06/06 - 20060148001 - Compositions and methods for treating female fertility The PTX3 gene or equivalent PTX3 activity is required for female fertility. Manipulation of PTX3 activity will regulate female fertility. The effects of female sterility may be ameliorated, reproductive ability may be increased or decreased as desired, female fertility may be enhanced, or combinations thereof. The need for therapies that ... 07/06/06 - 20060148000 - Methods for identifying modulators of n-type ion channel inactivation Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an a-subunit of a voltage gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have ... 07/06/06 - 20060147999 - Method and apparatus for homology-based complex detection in a protein-protein interaction network Provided are a method and a apparatus for detecting a protein complex using a similarity between different proteins in a protein-protein interaction network. The method includes: (a) producing a virtual complex of a specific organism by mapping proteins contained in a complex of a different organism into proteins of the ... 07/06/06 - 20060147998 - Method for diagnosing and monitoring critically ill patients Provided is an improved method of diagnosing and monitoring hemostatic dysfunction, sepsis-related morbidity or severe infection by improving detection of an in vitro complex formed by lipoprotein and C-reactive protein with the utilization of an effective amount of a surface active agent in the reagent. ... 07/06/06 - 20060147997 - Penetrabodies: receptor-mediated targeted delivery of functionally-active human antibody fragments into cytosol for the treatment of chronic infections and diseases The present invention relates to methods of making and using chimeric antibody molecules comprised of at least two domains, namely RAF, and IAF, linked by a flexible peptide linker. ... 07/06/06 - 20060147996 - Device for holding and detecting substance libraries The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the ... 07/06/06 - 20060147995 - Method for producing antibody fragments An expression library comprising a repertoire of nucleic acid sequences each encoding at least part of a variable domain of a heavy chain derived from an immunoglobulin naturally devoid of light chains and its use in producing antibodies, particularly fragments thereof, is disclosed. The invention provides a method for preparing ... 07/06/06 - 20060147993 - Membrane arrays and methods of manufacture The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR microarray of the invention comprises a membrane adhered to an upper surface of ... 07/06/06 - 20060147992 - Method for detection of bioactive peptides A method for the detection of bioactive peptides derived from a precursor protein or protein-containing biological extract, comprising the steps of: (i) providing a library of peptides derived from said precursor protein or protein-containing biological extract; (ii) optionally screening said library to confirm that it includes peptides exhibiting one or ... 06/29/06 - 20060141537 - Device and method for separating molecules An apparatus and method for separating a biomolecule from one or more contaminants in a sample. The apparatus can include a unitary device comprising a plurality of fractionation devices, each reservoir comprising a filter, each reservoir adapted to contain a solid phase, the solid phase adapted to separate the biomolecule ... 06/29/06 - 20060141536 - Scintillation proximity test The invention concerns scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350-450 nm) which is absorbed by yellow or brown assay components. This problem is addressed by the use of phosphors that emit radiation of ... 06/29/06 - 20060141535 - Hyaluronan receptor for endocytosis A purified nucleic acid segment encoding a functionally active hyaluronan receptor for endocytosis (HARE) or an active peptide fragment thereof, and methods for producing functionally active HARE or an active peptide fragment thereof therefrom, wherein the functionally active HARE or an active peptide fragment thereof is able to specifically bind ... 06/29/06 - 20060141533 - Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state The invention concerns arrays comprising hundreds, thousands, to hundreds of thousands of samples and methods for screening thereof. These methods are useful to optimize, select, and discover compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes. Such ... 06/29/06 - 20060141532 - Method for identifying and designing immunogenic peptides The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an ... 06/29/06 - 20060141531 - Ultra-high specificity fluorescent labeling A self-assembled relay probe for detecting a target material is provided including: a first peptide tag bound to the target material; and a first fluorescent conjugate including a first fluorochrome and a first tag binding group; wherein the first fluorescent conjugate selectively associates with the first tag. The probe further ... 06/29/06 - 20060141530 - Reagents and procedures for multi-label high-specificity labeling A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material; and a second peptide tag bound to the at least one target material. The complex further includes a ... 06/29/06 - 20060141529 - Compositions, kits and assays containing reagents directed to cortactin and an arg/abl protein kinase It has been determined Cortactin interacts with an ARG/ABL protein kinase. Thus, provided herein are compositions, kits and assays containing reagents directed to Cortactin and an ARG/ABL protein kinase. ... 06/29/06 - 20060141528 - Compositions and methods for quantification of serum glycoproteins The invention provides compositions and methods for identifying and/or quantifying glycopolypeptides from human serum or plasma. The compositions and methods include a plurality of standard peptides containing glycosylation sites determined for human serum/plasma proteins. ... 06/29/06 - 20060141527 - Method for creating a reference region and a sample region on a biosensor and the resulting biosensor A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used ... 06/29/06 - 20060141526 - Genetic marker for coronary artery disease The present invention describes a Coronary artery disease (CAD) susceptibility gene and the use of this gene in the development of novel therapies to treat CAD. ... 06/29/06 - 20060141525 - Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells It is intended to provide lectins and a lectin library comprising these lectins which are useful in recognizing differences in carbohydrates on cell surface (for example, sugar chains and cell surface glycoproteins) reflecting extremely subtle differences among cells, etc. and thus distinguishing, identifying or fractionating various cells. ... 06/22/06 - 20060134700 - Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 06/22/06 - 20060134699 - Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 06/22/06 - 20060134698 - Methods for treating cardiac disease by modifying an n-terminal domain of troponin i The invention provides methods for identifying modulators of cardiac troponin I activity as well as methods for using N-terminally truncated forms of cTnI to monitor the function of the circulatory system in general, and the heart in particular, of an organism such as man. Additionally, the invention provides methods of ... 06/22/06 - 20060134697 - Method of preparing coded compound libraries The present invention relates to methods of preparing a library of compounds, wherein each of the compounds resides on the exterior portion and is encoded by coding tags confined in each of successive zones on the interior portion of a solid support. Following screening of the compounds, the coding tags ... 06/22/06 - 20060134696 - Small molecule substrate based enzyme activity assays The invention relates to a method of high throughput chemical analysis comprising the steps of combining one test compound with a solution comprising m enzyme(s) and n substrate(s), wherein m is an integer equal to one or greater, n is an integer equal to one or greater, and m+n≧3, incubating ... 06/22/06 - 20060134695 - Biosensor surface structures and methods A biosensor surface with a low density of ligand-carrying tether molecules on a base layer. Also, surface plasmon resonance (SPR) devices have the biosensor surface attached to a thin gold layer with backside angle-spread incident radiation for resonance excitation and reflective detection. ... 06/22/06 - 20060134694 - Methods of protein profiling by thiolation Methods for analyzing a protein are provided, including isolating the protein having original reactive functional groups from a biological sample, and converting substantially all original reactive functional groups into thiol groups, followed by attaching tags to the protein via the thiol groups. ... 06/22/06 - 20060134693 - Olfactory cyclic nucleotide-gated channel cell-based assays to identify t1r and t2r taste modulators Screening assays, preferably high throughput, are provided that screen libraries of candidate compounds to identify agonists, antagonists, enhancers or modulators of taste receptors (bitter, sweet or savory (umami) taste receptor) using test cells that co-express at least one functional taste receptor and an olfactory cyclic nucleotide-gated channel (oCNGC). (The oCNGC ... 06/22/06 - 20060134692 - Target activated microtransfer A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular ... 06/22/06 - 20060134691 - Labeling methodology comprising oligopeptides A method for providing a labeled target protein or labeled target peptide in high purity, which method comprises the steps of a. contacting a chemical molecule, which chemical molecule comprises a target protein or a target peptide residue beside amino acid residues, spacer residues, and/or linker residues, an affinity tagging ... 06/22/06 - 20060134690 - Process for the purification of interleukin-4 and its muteins This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies. ... 06/15/06 - 20060127952 - Rapid diagnostic methods of peste des petits ruminants using recombinant nucleocapsid protein expressed in insect cells and monoclonal antibody The present invention relates to a diagnostic method of Peste des Petits Ruminants (PPR), a viral animal disease. More specifically, the invention relates to a new diagnostic method capable of detecting PPRV antibodies safely, simply and rapidly with recombinant Nucleocapsid (N) protein of PPR virus (PPRV) and specific monoclonal antibody ... 06/15/06 - 20060127951 - Screening system Bonding data regarding a great number of combinations of ligands and analytes are obtained within a short amount of time. Management of the bonding data and the corresponding analyte is automatically performed. A ligand solution is supplied to a thin film layer of a measurement unit, prior to measurement by ... 06/15/06 - 20060127950 - Methods and products related to the improved analysis of carbohydrates The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are ... 06/15/06 - 20060127949 - Device for detecting molecules, method for detecting molecules A construct is provided that is capable of binding a plurality of molecules, the construct comprising a first moiety with a first molecule binding region and a first molecule non-binding region; and a second moiety with a second molecule-binding region and a second molecule-non-binding region, whereby the first binding region ... 06/15/06 - 20060127948 - Analysis of proteins from biological fluids using mass spectrometric immunoassay Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound ... 06/15/06 - 20060127947 - Receptor deorphanization using tagged molecular libraries The present invention provides a method of screening test compounds and test conditions for the ability to modulate (activate or inhibit, enhance or depress) a GPCR pathway, and provides methods of assessing GPCR pathway function, such as the function of an orphan GPCR, in a cell in general. In another ... 06/15/06 - 20060127946 - Reading of fluorescent arrays Reading of fluorescent arrays (103) in clinical settings is made possible by a reader (110) constructed to employ dark field illumination of the array, and mapping an image of the array onto a solid state sensor array (146) with image dimensions (D;) of the same order magnitude as the dimensions ... 06/15/06 - 20060127945 - Method for determining endoglycosidase enzyme activity The invention relates to a method for determining endoglycosidase enzyme activity, and in particular of the heparanase type, in a sample, and also to a method for detecting a compound capable of modulating the activity of an endoglycosidase, and in particular of an endoglycosidase having activity of the heparanase type, ... 06/08/06 - 20060121536 - Novel uses of antibodies against ache and peptides thereof The invention relates to antibodies recognizing acetylcholinesterase or a C-terminal peptide derived from acetyl-cholinesterase, useful in diagnosing central nervous system (CNS) stress, elevated glucocorticoid level, disruption of the blood-brain barrier or Alzheimer's disease. The invention also relates to methods for the diagnosis of central nervous system (CNS) stress, elevated glucocorticoid ... 06/08/06 - 20060121535 - Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect biomolecules and to measure their concentration, binding affinity, and kinetics. Peptides, proteins, fusion proteins, protein complexes, nucleic acids, and the like, are labeled with an acrylic ... 06/08/06 - 20060121534 - Methods for culturing mammalian taste cells The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of ... 06/08/06 - 20060121533 - Analysis of proteins from biological fluids using mass spectrometric immunoassay Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound ... 06/08/06 - 20060121532 - Glycated insulin as a biomarker for diagnosis and monitoring of diabetes One of the major pathophysiological consequences of long term elevation of plasma glucose in diabetes is an increase in the non-enzymatic glycation of proteins. Contrary to expectations the present inventors have determined that individuals with well controlled short duration diabetes have particularly high concentrations of glycated insulin which decrease with ... 06/08/06 - 20060121531 - Piezoelectric bio-chip for detecting pathogen of mad cow disease and thereon preparation The present invention relates to the device for animal inspection and quarantine and the preparation method thereof. The present invention is especially applicable to the detection of the pathogen of bovine spongiform encephalopathy (BSE) (also known as “mad cow disease”). The present invention employs a piezoelectric chip, a microelectrode array ... 06/08/06 - 20060121530 - Disaccharides for drug discovery Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention ... 06/01/06 - 20060115859 - Tyrosylprotein sulfotransferases and methods of use thereof Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform ... 06/01/06 - 20060115858 - Trace amine 1 receptor of the african green monkey A trace amine receptor 1 has been isolated from the genome of Cercopithecus aethiops (African green monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes that are agonists or antagonists of the receptor. ... 06/01/06 - 20060115857 - Molecular wire injection sensors Disclosed is a sensor for sensing the presence of an analyte component without relying on redox mediators. This sensor includes (a) a plurality of conductive polymer strands each having at least a first end and a second end and each aligned in a substantially common orientation; (b) a plurality of ... 06/01/06 - 20060115856 - 2'-5'-oligoadenylate synthetase like protein as a biomarker for neurodegenerative disease The present invention relates to a biomarker for neurodegenerative disease, including amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), and Parkinson's (PD) disease. More particularly, the present invention relates to the identification of an 2′-5′-oligoadenylate synthetase like protein (p59 OASL) related protein as a biomarker useful for the detection, diagnosis, and differentiation ... 06/01/06 - 20060115855 - Fk506-binding protein 7 related protein as a biomarker for neurodegenerative disease The present invention relates to a biomarker for neurodegenerative disease, including amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), and Parkinson's (PD) disease. More particularly, the present invention relates to the identification of the FK 506-binding protein 7, or prolylisomerase, as a biomarker useful for the detection, diagnosis, and differentiation of neurodegenerative ... 06/01/06 - 20060115854 - Acetyl-ldl receptor related proteins and peptides as a biomarker for neurodegenerative disease The present invention relates to a biomarker for neurodegenerative disease, including amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), and Parkinson's (PD) disease. More particularly, the present invention relates to the identification of an acetyl-LDL receptor related protein as a biomarker useful for the detection, diagnosis, and differentiation of neurodegenerative disease, including ... 05/25/06 - 20060110777 - Structured peptide scaffold for displaying turn libraries on phage The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. One aspect of the invention is directed to cyclic peptide ... 05/25/06 - 20060110776 - Method of detecting native probnp The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody ... 05/25/06 - 20060110775 - Method of detecting native probnp The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody ... 05/25/06 - 20060110774 - Methods for detecting sepsis Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the concentration of GRK compared to that of a normal, healthy control sample indicates that the subject from which the ... 05/25/06 - 20060110773 - Marker for inflammatory conditions Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. ... 05/25/06 - 20060110772 - Human and murine cytokine polypeptides This invention relates to IMX7189 cytokines and to new members of the human cytokine polypeptide family, methods of making such polypeptides, and to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to identify compounds that alter cytokine ... 05/25/06 - 20060110771 - Proteins capable of binding to female sex hormones and process for producing the same The present invention provides a protein capable of binding to a female sex hormone, which protein is supplemented with useful properties for measuring, quantifying and concentrating female sex hormones, such as high sensitivity, low cross-reactivity, unlikelihood of being influenced by interfering substances, and unlikelihood of being influenced by solvents. Specifically, ... 05/18/06 - 20060105397 - Method for the detection of stress biomarkers including cortisol by fluorescence polarization The inventive subject matter relates to a competitive method measuring stress biomarkers in bodily fluids including serum, urine and oral fluids including saliva. The inventive method measures biomarkers including cortisol, melatonin and secretory IgA by fluorescence polarization fluorescence lifetime analysis or fluorescence resonance energy transfer. ... 05/18/06 - 20060105396 - Novel epithelial tissue imaging agent Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having β-sheet character, each of the domains being separated by domains lacking β-sheet character. The targeting molecule specifically binds ... 05/18/06 - 20060105395 - Methods and systems for positioning microspheres for imaging Various methods and systems for positioning microspheres for imaging are provided. One system includes a filter medium that includes openings. The openings are spaced in a substantially equidistant manner across the filter medium. The system also includes a flow subsystem coupled to the filter medium. The flow subsystem is configured ... 05/18/06 - 20060105394 - Methods and compositions for treatment and prevention of major depressive disorder The present invention relates to methods of diagnosing, prognosing or treating diseases or disorders in which elevated levels of Abeta protein, including abeta1-42 are prevalent. In particular, the present invention relates to methods of diagnosing, prognosing or treating a major or minor depressive episode/disorder attributed to elevated levels of Abeta ... 05/18/06 - 20060105393 - Ligand-receptor tracking assays The present invention provides an image-based method of screening for compounds based on the measurement of internalization of a fluorescently labeled ligand. It further provides a multiplex method for high content screening of compounds wherein at least two cellular parameters are measured. ... 05/18/06 - 20060105392 - Differential diagnosis of vitamin b12, vitamin b6, and folic acid disorders The invention concerns a method for determining vitamin B12, B6 or/and folic acid disorders and in particular the differential diagnosis of vitamin B12, vitamin B6 or/and folic acid disorders by means of three or four independent parameters. The differential diagnosis can be used to detect a vitamin B12, vitamin B6 ... 05/18/06 - 20060105391 - Device and method for separating molecules An apparatus and method for separating a biomolecule from one or more contaminants in a sample. The apparatus can include a unitary device comprising a plurality of fractionation devices, each reservoir comprising a filter, each reservoir adapted to contain a solid phase, the solid phase adapted to separate the biomolecule ... 05/18/06 - 20060105390 - Method of characterizing heterogeneity in receptor-ligand interactions and related method of assay signal histogram transformation Disclosed is a method for increasing the degree of confidence in receptor-ligand and probe-target interaction assays involving ligand or target capture by a heterogeneous population of receptors or probes displayed on solid phase carriers. The method comprises a process of establishing a weight function reflecting the heterogeneity in the receptor ... 05/18/06 - 20060105389 - Method for obtaining single chain antibodies to human interferon alpha2b A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the periplasm of E. coli by secretion. By this approach, approximately 104 clones can be ... 05/18/06 - 20060105388 - Incorporation of hapten groups during the production of carriers for the determination of analytes The invention relates to a method for producing a carrier, especially microfluidic carrier, for the determination of analytes. ... 05/18/06 - 20060105387 - Transferrin fusion proteins libraries Modified fusion proteins of transferrin and therapeutic proteins or peptides with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor. ... 05/11/06 - 20060099650 - Toll-like receptor assays Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR are described. Methods of identifying molecules that interact with a TLR are also described. ... 05/11/06 - 20060099649 - Method and apparatus for assay for multiple analytes A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each element is laid out in a predetermined pattern. Each pattern is unique in that it can give rise to a ... 05/11/06 - 20060099648 - Compositions and methods for epitope mapping The invention provides a composition comprising a diverse population of reagent ligands attached to a solid support and a diverse population of reagent antibodies specifically bound to the reagent ligands. The ligands can be peptides, oligosaccharides, oligonucleotides, or organic molecules. The invention additionally provides methods of determining an epitope in ... 05/11/06 - 20060099647 - Methods of identifying kinetically stable proteins The present invention provides a fast and efficient means for identifying kinetically stable proteins. As used herein the term “kinetically stable protein” means a protein that is trapped in a specific conformation due to an unusually high unfolding barrier that results in very slow unfolding rates. The present inventors are ... 05/11/06 - 20060099646 - Bret assay An improved BRET assay, wherein the BRET signal is enhanced and/or prolonged. The improved BRET assay comprises the steps of i) adding a substrate to a cell comprising GPCR-Rluc fusion protein and a β-arrestin-GFP fusion protein, wherein the (β-arrestin is mutated, ii) adding a ligand to obtain, if possible, a ... 05/11/06 - 20060099645 - Methods and reagents for assaying molecular interactions The invention relates to methods and reagents for screening, identifying, and/or quantifying molecular interactions. In particular, the invention provides a method for identifying protein-protein interactions comprising prey proteins interacting with bait proteins comprising: (a) introducing one or more prey protein in cells, wherein a prey protein is labelled with an ... 05/11/06 - 20060099644 - Method of assaying oxidized ldl-beta 2-glycoprotein i complexin vivo A complex having oxLDL bound covalently to β2-GPI can be used as a standard for measuring a β2-GPI/oxLDL complex in the living body thereby measuring the β2-GPI/oxLDL complex in the living body more accurately and strictly, and can be utilized to provide a new measurement method, detection method, kit etc. ... 05/11/06 - 20060099643 - Method for determining the regulation of xenobiotic removal The present invention relates generally to a method for identifying ligands that affect xenobiotic removal based upon their ability to modify the stability of receptors that regulate cytochrome P450 expression and/or drug transport proteins. ... 05/11/06 - 20060099642 - Solid-phase substrate for immobilizing biomolecules The invention relates to a solid phase substrate comprising at least one binding area, which is suited for immobilizing biomolecules. The solid phase substrate is characterized in that the substrate has, in the binding area, reactive binding sites at which polyol prefabricated by means of covalent bonds is immobilized. ... 05/11/06 - 20060099641 - Method of making libraries and anti-ligands The invention relates to methods of making anti-ligand libraries, which anti-ligands have a cavity binding site. The method comprises providing a plurality of anti-ligands having a cavity for binding a ligand, said plurality of anti-ligands being derived from a first anti-ligand having a cavity for binding a first ligand and ... 05/04/06 - 20060094063 - Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or ... 05/04/06 - 20060094062 - Ultra high throughput capture lift screening methods The present invention relates to a method for identification and isolation of binding molecules having a selective affinity for a ligand. More specifically, this invention provides a process for the ultra high throughput screening of binding molecules from expression libraries containing billions of independent clones without the biases and limitations ... 05/04/06 - 20060094061 - Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid ... 05/04/06 - 20060094060 - Preparation and use of a reactive solid support surface A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling ... 05/04/06 - 20060094059 - Methods for identifying new drug leads and new therapeutic uses for known drugs The screening system utilizes dynamic measurements of pathway activity to detect the activities of drugs within cellular pathways. The methods of the invention can be used to identify previously unknown drug activities and therapeutic uses, even for drugs that have been well characterized with standard biochemical assays. We demonstrated the ... 05/04/06 - 20060094058 - Peptide sequence tags and method of using same Peptide sequence tags are identified and used to produce a class of global antibodies, which recognize all members of the GlnA protein sub-family with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to the major GlnA protein of the Glutamine Synthetase enzyme catalyzing ... 05/04/06 - 20060094057 - Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites inn living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art ... 05/04/06 - 20060094056 - Method of using cytokine assays to diagnose treat, and evaluate inflammatory and autoimmune diseases The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluid, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis, ... 04/27/06 - 20060088889 - Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by ... 04/27/06 - 20060088888 - Methods of identifying inhibitors of gadd45 polypeptide activity, and inhibitors of such activity The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability ... 04/27/06 - 20060088887 - Method for screening substance which can bind to receptor A method for screening a substance which can optimally bind to a receptor, by monomolecular fluorescent analysis, comprising a step of searching a substance which can bind to a receptor, and a step of performing optimization of a structure of the substance which can bind to the receptor obtained by ... 04/27/06 - 20060088886 - Topiramate analogs Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the ... 04/27/06 - 20060088885 - Immunoassays for topiramate Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the ... 04/27/06 - 20060088884 - Method of utilizing neurotrophins to manipulate reproductive capacity Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of ... 04/27/06 - 20060088883 - Recombinant catalytic polypeptides and their uses The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention ... 04/27/06 - 20060088882 - Methods for the treatment or prevention of obesity The invention provides methods for the treatment or prevention of obesity. The invention also provides screening methods for determining whether a compound is useful for the treatment or prevention of obesity. ... 04/20/06 - 20060084118 - T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The ... 04/20/06 - 20060084117 - Galphaq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors The invention provides a series of Gαq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. ... 04/20/06 - 20060084116 - Analysis of mhc-peptide binding interactions Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC construct is provided. A first component including at least one candidate peptides and a second component including at least one MHC construct are contacted. One of the components is immobilized on a solid support. The ... 04/20/06 - 20060084115 - Selective high affinity polydentate ligands and methods of making such This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or ... 04/20/06 - 20060084114 - Method for detecting cardiac collateral formation The present invention relates to a method of detecting collateral artery formation by measuring the level of NT-pro-BNP or BNP in an individual. ... 04/20/06 - 20060084113 - Directed evolution of disulfide-bonded micro-proteins In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore ... 04/20/06 - 20060084112 - Apolipoprotein biopolymer marker indicative of normal human The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 04/13/06 - 20060078945 - Complex formed by n-linked glycoproteins (siblings) and factor h The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in relatively acidic forms. The methods provided can be used to detect SIBLINGS proteins ... 04/13/06 - 20060078944 - Methods and reagents relating to inflammation and apoptosis The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-α) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-κB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further ... 04/13/06 - 20060078943 - Method for obtaining anti-idiotype antibodies A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c) ... 04/06/06 - 20060073522 - Fluorescently labeled growth hormone secretagogue The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening. ... 04/06/06 - 20060073521 - Method for forming a film by spin coating It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a ... 04/06/06 - 20060073520 - Specific antibody directed to active hepatocyte growth factor activator and method for using the same An antibody which recognizes an active hepatocyte growth factor activator (HGFA) and does not substantially recognize inactive HGFA is provided. Also disclosed is a monoclonal antibody thereof, and a hybridoma cell line for producing the monoclonal antibody. There is further provided a method for measuring active HGFA using the antibody, ... 04/06/06 - 20060073519 - Antibody specific to interleukin 18 precursor Disclosed are an antibody specific to interleukin 18 (IL-18) precursor, preparation processes therefor, and uses thereof. The antibody includes immunoglobulins in both forms of polyclonal and monoclonal antibodies which exhibits an immunoreactivity against IL-18 precursor at an intensity higher than against other substances. The antibody is useful in detection and ... 04/06/06 - 20060073518 - Method for selecting a candidate drug compound The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a ... 04/06/06 - 20060073517 - Post-translational modifications of proteins as regulatory switches The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and the carboxy terminus of the H2A and H2B peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-translational ... 04/06/06 - 20060073516 - Novel screening method Using a novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 2 or its salt together with β-alanine or L-carnosine, an agonist or an antagonist to the receptor ... 04/06/06 - 20060073515 - Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated. ... 04/06/06 - 20060073514 - Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in ... 03/30/06 - 20060068445 - Novel soluble cd14 antigen There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in ... 03/30/06 - 20060068444 - Compositions and methods for detecting cyclic analogs of hpth The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of levels of cyclic analogs of hPTH in sample fluids, such as serum or plasma. The antibodies ... 03/30/06 - 20060068443 - Universal binding matrix for creating pairing ligands for identifying proteomic interaction A Universal Binding Matrix is described which binds various classes of combinatorial libraries. This bound library can then be probed with test species of a simple or complex nature to identify complementary test species as well as test species surface mimics. These complementary test species have the characteristic of binding ... 03/23/06 - 20060063207 - Reconfigurable protein patterning using electrowetting microelectrodes A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called “electrowetting,” where surface wettability can dynamically be controlled by varying the voltage across the device electrodes. When an electric field is applied ... 03/23/06 - 20060063206 - Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and ... 03/23/06 - 20060063205 - Combinatorial artificial receptors including tether building blocks The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes ... 03/23/06 - 20060063204 - Diagnostic markers of acute coronary syndrome and methods of use thereof The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for ... 03/23/06 - 20060063203 - Vascular endothelial cell growth factor variants and uses thereof The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided. ... 03/23/06 - 20060063202 - High throughput method and system for screening candidate compounds for activity against epilepsy and other neurological diseases Methods and systems of compound screening are provided. Screening methods and instrumentation for candidate pharmacological agents are applied to discover compounds with particular activity against epilepsy. The method employs teleost fish, such as the medaka (Orzyias latipes), which are stimulated with a threshold electric field to produce convulsive behavior. The ... 03/23/06 - 20060063201 - Crystals of the fc region of immunoglobulin epsilon heavy chain protein The present invention includes three-dimensional models of antibodies, such as Fc-Cε3/Cε4 regions of IgE antibodies, as well as methods to produce such models. The present invention also includes muteins having increased stability and/or antibody receptor binding activity, as well as methods to produce such muteins, preferably using information derived from ... 03/23/06 - 20060063200 - Therapeutic polypeptides, nucleic acids encoding same, and methods of use Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic ... 03/23/06 - 20060063199 - Diagnostic marker An inflammatory peptide can be a marker for cardiac ischemia. ... 03/23/06 - 20060063198 - Diagnostic marker An inflammatory peptide can be a marker for cardiac ischemia. ... 03/23/06 - 20060063197 - Quality control and normalization methods for protein microarrays The use of fluorescent dye in printing buffer used to print spots of a protein microarray permits the presence, location and morphology of individual spots to be detected based on the fluorescent response of the spots. This information can be used to perform quality control of protein microarrays. In addition, ... 03/23/06 - 20060063196 - Targeted molecular bar codes and methods for using the same Targeted molecular bar codes and methods for using the same are provided. The subject targeted molecular bar codes include a molecular bar code and a member of a specific binding pair, where the specific binding pair member is generally bonded to the bar code through a linking group. The subject ... 03/16/06 - 20060057644 - Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific ... 03/16/06 - 20060057643 - Methods and compositions for detecting erythrovirus genotypes The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of human erythroviruses, such as the B19, V9, and A6 genotype, in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region ... 03/16/06 - 20060057642 - Disease markers for early stage atherosclerosis The invention relates to methods of diagnosing early stages of atherosclerosis. ... 03/16/06 - 20060057641 - Allergenic proteins and peptides from dog dander and uses therefor Isolated nucleic acids encoding allergens of Canis familiaris, Canf I or Can f II. are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and ... 03/16/06 - 20060057640 - Modulators of odorant receptors The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and ... 03/16/06 - 20060057639 - Camkii/calcium channel phosphorylation-related compositions and methods This invention provides a method for determining whether an agent inhibits phosphorylation of a calcium channel by CaMKII. Furthermore, this invention provides a method of inhibiting phosphorylation of a calcium channel by CaMKII in a cell. Finally, this invention provides methods for treating cardiac arrhythmia and neurological disorders. ... 03/16/06 - 20060057638 - Methods and products related to the improved analysis of carbohydrates The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the ... 03/16/06 - 20060057637 - Inorganic particle conjugates The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets. ... 03/16/06 - 20060057636 - Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins The present invention relates to diseases caused by prion proteins, Novel composite peptide compounds are disclosed which comprise two or more peptides or peptide fragments optionally linked to a backbone and the peptides or peptide fragments are spatially positioned relative to each other so that they together form a non-linear ... 03/16/06 - 20060057635 - Coated metal surface on solid support for displacement reactions A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl ... 03/16/06 - 20060057634 - Assay for glycosylated proteins The invention provides a method for assaying for a protein having at least two isoforms having different glycosylation patterns, said method comprising: contacting a sample containing said protein with a carbohydrate-binding agent and a ligand capable of binding to at least two said isoforms, and detecting conjugates of said carbohydrate-binding ... 03/16/06 - 20060057633 - Methods of creating modified promoters resulting in varying levels of gene expression The present invention relates to a method of creating promoter cassettes that include modified precursor promoters and transforming a population of bacterial host cells with a promoter library comprising the promoter cassettes resulting in bacterial clones having a range of expression levels of a gene of interest. The invention further ... 03/16/06 - 20060057632 - Artificial antibody library with super-repertory An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method; ... 03/09/06 - 20060051814 - Methods for predicting outcome in traumatic brain injury The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse ... 03/09/06 - 20060051813 - Diagnostic method for a transmissible spongiform encephalopathy or prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or platelet cell lineages in the sample or an expression product ... 03/09/06 - 20060051812 - Novel carbohydrate compositions and a process of preparing same The present invention is directed to novel methods to produce carbohydrate polymers and oligomers especially for pharmaceutical and food industries. The invention is directed to methods to remodel monosaccharides, and/or oligosaccharides and/or polysaccharides by a different monosaccharide, oligosaccharide or polysaccharide and optionally by further alcohol substances, under condensing conditions, preferably ... 03/09/06 - 20060051811 - Site-specific labelling of proteins using acridone and quinacridone lifetime dyes wherein B is an affinity tag; and L1 and L2 each independently comprise a group containing from 1 to 40 linked atoms selected from carbon atoms which may optionally include one or more groups selected from —NR′—, —O—, —CH═CH—, —CO—NH— and phenylenyl groups, where R′ is selected from hydrogen and ... 03/02/06 - 20060046271 - Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides A method for assessing cancer susceptibility to molecular targeted therapy. Also provided are methods for in vivo panning of diverse molecules for isolation of targeting ligands that specifically bind an apoptotic cell associated with a responding tumor, targeting ligands identified by the panning methods, and diagnostic and imaging uses therefor. ... 03/02/06 - 20060046270 - Analytical method The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance. ... 03/02/06 - 20060046269 - Methods and devices for processing chemical arrays The subject invention provides methods and devices for processing at least one chemical array on a flexible substrate. Also provided are methods of using chemical arrays produced according to the subject invention, and arrays processing according to the subject methods, and arrays processed according to the subject methods, as well ... 03/02/06 - 20060046268 - Diagnosis of anemia and optimizing treatment for heart repair A method of diagnosis of anemia is disclosed whereby blood is withdrawn from a patient and the level of hematopoietic stem cells (HSC) in the blood are determined by detecting a cell surface protein chosen from ACE+, CD34+, CD38, CD90+ (thyl) and Lin−. Patients with low levels of HSC are ... 03/02/06 - 20060046267 - Method for identification and determination of hypersensitivity of a patient to abacavir A method for identifying whether a patient will exhibit a hypersensitive reaction or like-reaction to treatment with abacavir comprising the step of: typing the patient for the presence of the 57.1 ancestral haplotype. ... 02/23/06 - 20060040328 - Rabconnectin-3-binding protein A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an ... 02/23/06 - 20060040327 - Methods of screening proteins The present invention relates to methods of screening or isolating stable mutant binding proteins from a protein library of mutant proteins. The methods comprise culturing host cells under conditions suitable for protein expression. The collection of host cells comprise collectively a set of expression vectors, and this collection of expression ... 02/23/06 - 20060040326 - Method for measuring reaction rate coefficient by surface plasmon resonance analysis An object of the present invention is to provide a method for measuring a rate coefficient by surface plasmon resonance analysis with excellent accuracy, reliability, and cost performance that can improve the assay accuracy and simplify the apparatus. The present invention is provides a method for determining the adsorption rate ... 02/23/06 - 20060040325 - Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity The present invention relates to novel Fc variants of antibodies that immunospecifically binds to Integrin αvβ3. The Fc variants comprise a variable region that immunospecifically binds to Integrin αvβ3 and a Fc region that further comprises at least one novel amino acid residue which may provide for enhanced effector function. ... 02/23/06 - 20060040324 - Methods for making metallopeptides and metallopeptide libraries where X is a plurality of amino acids and includes a complexing backbone for complexing metal ions, so that substantially all of the valences of the metal ion are satisfied upon complexation of the metal ion with X, resulting in a specific regional secondary structure forming a part of the ... 02/23/06 - 20060040323 - Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of ... 02/23/06 - 20060040322 - Method of construction and selection of virtual libraries in combinatorial chemistry A method of construction and selection of virtual libraries in combinatorial chemistry is described, comprising the steps of: preparing a three-dimensional structure of a target macromolecule (PROT); determining one or more receptor sites of the macromolecular target (PROT); creating a first virtual library (300) of compounds starting with at least ... 02/23/06 - 20060040321 - Orphan receptor tlx and uses therefor In accordance with the present invention, there are provided methods for identifying compounds which modulate the activity of TLX. Such compounds will find use in a wide variety of applications, e.g., methods for relieving TLX-mediated transcription repression and/or inducing processes mediated by TLX, methods for inhibiting processes mediated by TLX, ... 02/23/06 - 20060040319 - Multiple sensor-containing active modified polypeptides, preparation and uses thereof Compositions and methods are provided for identifying conformational changes in polypeptides related to the activity or biological state of the polypeptide. Semisynthetic polypeptides are prepared comprising at least two proximity-sensor peptides, the resultant composition capable of detectably indicating the activity of biological state of the polypeptide. Such compositions may be ... 02/23/06 - 20060040318 - Novel application of nanotechnology and sensor technologies for ex-vivo diagnostics Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for identifying the presence of a target analyte/biomarker in a sample of bodily ... 02/16/06 - 20060035284 - Methods for isolating molecular mimetics of unique neisseria meningitidis serogroup b epitopes Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique epitopes found on MenB or E. coli ... 02/16/06 - 20060035283 - Neuroprotective therapeutics and assays for identifying the same Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided. ... 02/16/06 - 20060035282 - Assessing risk for kidney stones The present invention relates to identifying the risk of a subject developing renal stones utilizing an assessment of PTH agonist, antagonist and/or total PTH levels, optionally together with an assessment of serum and/or urine calcium levels and/or other analytes. The present description further relates to monitoring and guiding treatment for ... 02/16/06 - 20060035281 - Methods and systems for generating peptides Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods ... 02/16/06 - 20060035280 - Screening methods for inhibitors of protein-protein binding interactions Protein-protein interactions represent a large and important group of drug targets involved in the development and progression of human diseases. However, their utilization in drug discovery has been hampered by the low probability of identifying small-molecule inhibitors able to disrupt protein binding with desirable potency and selectivity. Therefore, the capability ... 02/16/06 - 20060035279 - Anti-gpe antibodies, their uses and assays for weakly immunogenic molecules Anti-GPE antibodies are provided that can be used to detect the presence of GPE in a sample. GPE antibodies can be raised against conjugated GPE to produce antibodies that are specific for a GPE that has been derivatized using a similar coupling chemistry as was used for making the GPE ... 02/16/06 - 20060035278 - Methods and compositions for modulating hgf/met The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating binding of HGF β chain to c-met. ... 02/16/06 - 20060035277 - Capture arrays using polypeptide capture agents A method of evaluating for the presence of a polypeptide in an analyte, using an addressable array of capture agents linked to a substrate. The analyte is exposed to the array and a set of fixed capture agents, such that the target molecules will bind to the array by means ... 02/16/06 - 20060035276 - Membrane protein library for proteome analysis and method for preparing same The present invention provides a library of membrane protein-embedded liposomes suitable for proteome analysis, a method for preparing same and a proteome analysis method using same. ... 02/09/06 - 20060029982 - Stable calibrators or controls for measuring human natriuretic peptides The present invention relates to stable calibrators and controls that can be used in ligand-binding assays and methods for making said calibrators and controls. ... 02/09/06 - 20060029981 - Ingap displacement assays An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension. ... 02/09/06 - 20060029980 - Method for diagnosing obstructive sleep apnea A method for diagnosing obstructive sleep apnea in a patient comprises identifying at least one protein biomarker for obstructive sleep apnea; obtaining a sample from the patient; and testing the sample for presence of the at least one protein biomarker. The protein biomarkers may include alpha-1 B-glycoprotein; kallikrein, laminin, aldosterone-binding ... 02/09/06 - 20060029979 - Electrochemical luminescence composite material with anti-biofouling properties The present invention relates to the preparation ad application of a high-sensitive electrochemical luminescent composite material which has anti-biofouling properties useful as a sensor material. This material is prepared by immobilization of electrochemical luminescent material into polymer containing phospholipid groups, wherein, the electrochemical luminescent material including ruthenium complex, osmium complex, ... 02/09/06 - 20060029978 - Methods and devices for analyte detection Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays. ... 02/09/06 - 20060029977 - Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry Disclosed are methods, compositions and kits for diagnosing prion-mediated pathological conditions and presence of aberrant prion protein in animal derived products, utilizing mass spectrometry. ... 02/09/06 - 20060029976 - Method for the detection of c-reactive protein in mammalian fluids A method of determining if the concentration of CRP in biological fluids of a mammal is above a predetermined relative risk level indicative of future cardiac problems. The method includes the steps of taking a sample of biological fluid and applying the sample to a position on a protein binding ... 02/02/06 - 20060024755 - Biopolymer marker indicative of disease state having a molecular weight of 1424 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 02/02/06 - 20060024754 - Methods and compositions for using mhc class ii invariant chain polypeptide as a receptor for macrophage migration inhibitory factor Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, ... 02/02/06 - 20060024753 - Immunoglobulin-positive neurons in alzheimer disease are dying via the classical, antibody-dependent, complement pathway Ig-positive neurons, which have been shown to be present in Alzheimer's disease, are shown to have complement C1q and C5b-9 proteins. C1q and C5b-9 can be employed in diagnosis and treatment of Alzheimer's disease. ... 02/02/06 - 20060024752 - Cytoxan antibodies and immunoassay Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide. ... 02/02/06 - 20060024751 - Scale-up methods and systems for performing the same The present invention provides methods of and systems for translating conditions from a small-volume experiment to a larger-volume experiment. ... 02/02/06 - 20060024750 - Compositions and methods comprising a ligand of chemerin r The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related ... 02/02/06 - 20060024749 - Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, and optionally measuring other biomarkers such as homocysteine and glutamate. The ... 02/02/06 - 20060024748 - Cytoxan antibodies and immunoassay Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide. ... 02/02/06 - 20060024747 - Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-mgam-4d and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to the corresponding amides, and the amidase is useful for hydrolysis of amides to ... 02/02/06 - 20060024746 - Methods and devices for optical monitoring and rapid analysis of drying droplets Devices for optical monitoring and rapid analysis of a drying droplet are presented and include a droplet deposition means, an optical recording means, and a computer control and image analysis means. In several preferred embodiments, a pipette is used to deposit one or more droplets in parallel onto a slide, ... 02/02/06 - 20060024745 - Variants of factor xlla Factor XIIa (activated Factor XII) exists in a variety of forms in the blood. Measurement of different forms provides information relevant for diagnosing, monitoring, or predicting the susceptibility to, progress of, or outcome of a disease or disorder, or of treatment of the disease or disorder in a subject having ... 02/02/06 - 20060024744 - Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte Methods are provided for monitoring treatment of a subject using heparin therapy or a ligand, such as an CD20 or CD52 antibody, that binds to a cellular marker and to which the subject may develop masking reactions or auto-antibodies that inhibit evaluation of treatment. The methods involve adding to a ... 01/26/06 - 20060019316 - Apparatus and method for automated protein design The present invention relates to apparatus and methods for quantitative protein design and optimization. ... 01/26/06 - 20060019315 - Multimarker panel for diabetes type 1 and 2 The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular ... 01/26/06 - 20060019314 - Increasing life span by modulation of smek The Smek (Suppressor of mek null) gene is described and characterized. Smek acts in the stress response pathway of animals by binding to and enhancing the transcription of FOXO, thereby providing the link between the stress response pathway and the insulin/IGF-1 pathway. Given the link between both the stress response ... 01/26/06 - 20060019313 - Method for detecting molecular surface interactions A method for determining interaction of an analyte with a binding agent immobilized to a solid support surface by contacting the surface with a fluid sample containing the analyte, and detecting binding events at the solid support surface, wherein the sample is based on a complex medium containing at least ... 01/26/06 - 20060019312 - Cis-interactions between mhc molecules and co-expressed proteins, related neurological and non-neurological disorders and related therapeutic/diagnostic utilities The present invention relates to the interactions between MHC Class I molecules and Co-expressed Proteins within the same cell (i.e., cis interaction). These interactions affect overt functional cellular processes by way of influencing protein trafficking and/or signal transduction. For example, in the nervous system, MHC Class I/Co-expressed Protein Interactions can ... 01/26/06 - 20060019311 - Process for detecting prp using a macrocyclic adjuvant ligand A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and ... 01/26/06 - 20060019310 - Cell regulatory genes, encoded products, and uses related thereto Disclosed herein are methods for diagnosing cancer in a biological sample comprising measuring the level of a p63 gene product in the sample. ... 01/26/06 - 20060019309 - Self-assembling peptide surfaces for cell patterning and interactions This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs. ... 01/26/06 - 20060019308 - Cd38 modulated chemotaxis The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, ... 01/26/06 - 20060019307 - Interleukin-8 homologous polypeptides and therapeutic uses thereof The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies ... 01/19/06 - 20060014217 - Sphingomyelin detecting probe An object of the present invention is to provide a protein useful as a sphingomyelin detecting probe, which specifically recognizes sphingomyelin and has low cytotoxicity. The present invention provides a protein which has an amino acid sequence having, as the amino acid sequence from the 1st to the 48th amino ... 01/19/06 - 20060014216 - Inhibition of tau-tau-association A composition and use thereof for the prophylaxis or treatment of Alzheimer's disease, motor neurone disease, Lewy body disease, Pick's disease or progressive supranuclear palsy. The composition includes an agent which modulates or inhibits tau-tau association and which does not inhibit tau-tubulin binding. In the method the agent is administered ... 01/19/06 - 20060014215 - Process for detecting prpsc using an antibiotic from the family of aminoglycosides A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of ... 01/19/06 - 20060014214 - Urine preservation system An improved method of preserving a molecule in a bodily fluid comprises: (1) providing a preservative solution comprising: (a) an amount of a divalent metal chelator selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), (ethylenebis(oxyethylenenitrilo))tetraacetic acid (EGTA), and 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) and salts thereof in the range of from ... 01/19/06 - 20060014213 - Methods for rapid screening of mad cow disease and other transmissible spongiform encephalopathies Methods for diagnosing altered neuropathology in an animal are disclosed, wherein said methods comprise imaging brain, spinal cord, or other neural tissue of the animal, analyzing the appearance of the tissue, and determining whether the appearance of the tissue is altered relative to corresponding unaltered tissue. Also disclosed are methods ... 01/19/06 - 20060014212 - Proteome epitope tags and methods of use thereof in protein modification analysis Disclosed are reagents and methods for reliably detecting the presence and measuring the amount of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a ... 01/19/06 - 20060014211 - Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity The invention relates to methods and kits for assessing occurrence in patient mesothelial fluid of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of mesothelioma patients. The methods and kits can be used ... 01/19/06 - 20060014210 - Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry Serial derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the ... 01/19/06 - 20060014209 - Method for differentiation of alzheimer's disease into subgroups A method for diagnosing distinct subgroups of Alzheimer's Disease, the method comprising the steps of obtaining a sample of cerebrospinal fluid and determining the level of ubiquitin, the level of Aβ1-42, and the level of tau present in the sample. Based on the levels of each composition in the cerebrospinal ... 01/19/06 - 20060014208 - Functional assays for identifying compounds that modulate t1r2/t1r3 (sweet) taste Functional assays for identifying compounds that activate or modulate the activation of the T1R2/T1R3 (sweet) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R2/T1R3 (sweet) taste receptor or on the activation of T1R2/T1R3 sweet taste receptor by another, compound e.g., ... 01/19/06 - 20060014207 - Method of measuring lipid in specific lipoprotein A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid. ... 01/19/06 - 20060014206 - Assay methods for state-dependent calcium channel agonists/antagonists Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ cells transfected with a voltage-gated ion channel of interest and a corollary channel to control the membrane potential of the cells by changing extracellular ion concentration. This allows for more convenient, more precise ... 01/12/06 - 20060008852 - Marine actinomycete taxon for drug and fermentation product discovery The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as ... 01/12/06 - 20060008851 - Methods for rapid and quantitative proteome analysis The invention provides methods for identifying a polypeptide. The method can include determining two or more characteristics associated with the polypeptide, or a fragment thereof, one of the characteristics being mass of a fragment of the polypeptide, the fragment mass being determined by mass spectrometry; comparing the characteristics associated with ... 01/12/06 - 20060008850 - Combinatorial synthesis of peg oligomer libraries A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For ... 01/12/06 - 20060008849 - Methods for measuring chloride channel conductivity The invention provides non-radioactive methods to assay for functional chloride channels. The methods colorimetrically detect the amount of iodide conducted by a chloride channel. They can be easily adapted for high throughput assays or screenings. ... 01/12/06 - 20060008848 - Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein ... 01/12/06 - 20060008847 - Mechanical cartridge with test strip fluid control features for use in a fluid analyte meter A structure for controlling fluid flow from a sample receiving pad into a lateral flow assay test strip, including: a lateral flow assay test strip; a sample pad abutting the lateral flow assay test strip; a pinch wall positioned to direct fluid flow from the sample pad to the lateral ... 01/12/06 - 20060008846 - Antagonism of tgf-beta superfamily receptor signaling Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening ... 01/12/06 - 20060008845 - Polypeptide compositions formed using a coiled-coil template and methods of use The invention relates to the use of constrained coiled-coil polypeptides to mimic α-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands which selectively bind the α-helical segment contained in the native protein. ... 01/12/06 - 20060008844 - C-met kinase binding proteins Polypeptides comprising monomer domains that bind to c-Met, or portions thereof, are provided. ... 01/12/06 - 20060008843 - Determination of protein function For purposes of determining the function of a protein, an automated system captures images of cells, each cell located in a predetermined well. After a given cell is exposed to a protein of interest, the system measures the responses of the cell over time, evaluating a variety of cellular parameters. ... 01/12/06 - 20060008842 - Method of measuring neprilysin activity The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin nerve cells ... 01/05/06 - 20060003386 - Metallopeptide combinatorial libraries and applications Method of making metallopeptide combinatorial libraries and metallopeptides are provided, for use in biological, pharmaceutical and related applications. The combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or ... 01/05/06 - 20060003385 - Mass intensity profiling system and uses thereof The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled ... 01/05/06 - 20060003384 - Detection of measurement of antibodies to antigenic proteins in biological tissues or samples The present invention relates to methods and compositions for detecting and/or measuring serum antibodies to antigenic proteins in a sample, comprising adding a labeled antigenic protein or fragment thereof to a sample derived from serum and expected to contain serum antibodies and measuring differences in at least one characteristic between ... 01/05/06 - 20060003383 - Fluorogenic enzyme activity assay methods and compositions using fragmentable linkers Substrate compound-containing micelles and various compositions, kits and methods for their preparation and use are provided. ... 01/05/06 - 20060003382 - Compositions and methods for analyte detection The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. In particular, the present invention provides probes of the outer-sphere environment of a redox center and methods of correlating changes in electrochemical properties to characterize the ... 01/05/06 - 20060003381 - Methods for assembling protein microarrays The invention provides methods for assembling protein arrays. In one aspect, the methods comprise use of charged or polar array surfaces in the construction of the array. The methods also comprise use of viscous solutions for the deposition of the polypeptides on the array surface in the construction of the ... 12/29/05 - 20050287601 - Diagnostics and therapeutics for macular degeneration-related disorders The invention relates to methods for diagnosing and treating macular degeneration-related disorders. The invention also related to methods for identifying genes that cause macular degeneration-related disorders. ... 12/29/05 - 20050287600 - Method for screening for agents preventing aggregation of potentially amyloidogenic proteins The present invention describes a method for identifying compounds capable of preventing the aggregation of potentially amyloidogenic proteins. The invention encompasses (1) missing the protein of interest with the compound to be assayed (b) gradually increasing the temperature (c) detecting the appearance of amyloid fibres by turbidimetric measurements, and/or by ... 12/29/05 - 20050287599 - Biopolymer marker indicative of disease state having a molecular weight of 1518 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/29/05 - 20050287598 - Method of preparing cow brain homogenate An assay method is disclosed which isolates and detects the presence of a disease related conformation of a protein (e.g., PrPSc) present in a sample also containing the non-disease related conformation of the protein (e.g., PrPC). The sample is treated (e.g., contacted with protease) in a manner which hydrolyzes the ... 12/29/05 - 20050287597 - Compositions and methods for modulating sirtuin activity The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. ... 12/29/05 - 20050287596 - Novel ligands and libraries of ligands wherein L, n, S and A are defined generally and subsets herein. These compounds and libraries of compounds are useful generally in the drug discovery process. ... 12/29/05 - 20050287595 - Macroglobulin biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ... 12/29/05 - 20050287594 - Proteomic analysis The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method ... 12/22/05 - 20050282231 - Screening assays for hedgehog agonists and antagonists The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods ... 12/22/05 - 20050282230 - Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind. ... 12/22/05 - 20050282229 - Methods and device for analyte characterization The methods and apparatus, disclosed herein are of use for sequencing and/or identifying proteins, polypeptides and/or peptides. Proteins containing labeled amino acid residues may be synthesized and passed through nanopores. A detector operably coupled to a nanopore may detect labeled amino acid residues as they pass through the nanopore. Distance ... 12/22/05 - 20050282228 - Methods and compositions for activating or inhibiting vegf-d and vegf-c Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a phamarceutical compositions comprising plasmin. Also disclosed are methods for screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. ... 12/15/05 - 20050277156 - Novel brain natriuretic peptide variants and methods of use thereof Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein. ... 12/08/05 - 20050272095 - Methods of identifying biomarkers The invention provides methods of isolating and identifying biological markers of diabetes and metabolic syndrome and complications of these disease states. The biomarkers are useful in the evaluation, diagnosis and monitoring of these diseases. ... 12/08/05 - 20050272094 - Purified antigen for alzheimer's disease and methods of obtaining and using same The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detectiing human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to ... 12/08/05 - 20050272093 - Assays for screening compounds which interact with cation channel proteins, mutant prokaryotic cation channel proteins, and uses thereof Assays for screeing potential drugs or agents that can interact and potentially bind to cation channel proteins, and potentially have uses in treating conditions related to the function of cation channel proteins is provided, along with prokaryotic cation channel proteins mutated to mimic eukaryotic cation channels, which can then be ... 12/01/05 - 20050266500 - Real time detection of intermolecular interaction Intermolecular binding can be detected by formation of a “paratope” which results in an immediate generation of a signal. The substances to be tested for interaction are bound to demitopes, wherein said demitopes are components of a paratope which binds a reporter which provides said signal when bound. Known interactions ... 12/01/05 - 20050266499 - Method and apparatus for testing for presence or absence of select biological substances A fluid flow test device comprising: a chromatography path of aqueous wicking material on which is deposited at an upstream site at a selected delivery time an aqueous biological sample to be tested for the presence or absence of a target material; a capture material bound to the wicking material ... 12/01/05 - 20050266498 - Method for screening biomolecule activity regulator A method for screening a low molecular weight substance which binds to a specific site of a biomolecule and may be usable as a starting material in drug development. This method comprises screening a substance that interacts with a specific region of a biomolecule having an activity, to regulate the ... 12/01/05 - 20050266497 - Method of assessing the risk of atherosclerosis A method for aiding in the determination of whether a living or deceased human is afflicted with or will likely have atherosclerosis respectfully, the method comprising determining the level of SPRR3 protein in a intimae or body fluid sample by using molecular localization analysis technique comparing the determined level of ... 12/01/05 - 20050266496 - Heterocyclic compounds, combinatorial libraries thereof and methods of selecting drug leads Heterocyclic compounds having a relatively flexible backbone are used to create combinatorial libraries that permit screening for lead compounds and selection of drug candidates for a variety of uses in human and veterinary medicine as well as in agriculture. The compounds of the library generally differ in ring size and ... 12/01/05 - 20050266495 - Method and program for library generation A library generation device determines a characteristic approximation function based on a characteristic extraction table to calculate characteristic data corresponding to a client's conditions in accordance with the characteristic approximation function. A library for verification including the calculated characteristic data and format information of a reference library is generated in ... 11/24/05 - 20050260686 - Multiplex flow assays preferably with magnetic particles as solid phase Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit ... 11/24/05 - 20050260685 - Arrays of biological membranes and methods and use thereof The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air ... 11/24/05 - 20050260684 - Method and probes for the detection of a tumor specific fusion protein This invention relates to the detection of fusion proteins. The invention provides a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least ... 11/24/05 - 20050260683 - Methods for diagnosing and treating pre-term labor In accordance with the present invention, recombinant human PBEF has been produced in order to study its ability to stimulate the transcription of the key cytokine mediators of labor induction, using the amnion-like epithelial (WISH) cell line and fetal membrane explants. As a result of these studies, it has been ... 11/24/05 - 20050260682 - Compositions and methods for diagnosing or treating psoriasis The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis. ... 11/24/05 - 20050260681 - Method of altering the binding specificity of proteins by oxidation-reduction reactions The binding specificity of at least one protein suspended or dissolved in a liquid medium is reversibly altered by exposing the protein to an oxidizing agent or an electric current. A masked protein such as an autoantibody can be detected, isolated and recovered from a biological fluid by subjecting the ... 11/24/05 - 20050260680 - Methods of diagnosing and treating autoimmune diseases The present invention provides methods of diagnosing autoimmune disorders selected from the group consisting of Sjögren's Syndrome and lupus in a subject based on detecting a difference between the subject and normal individuals in the levels of individual antibody classes and/or subclasses that are specific for Tf-like antigens. The present ... 11/24/05 - 20050260679 - Reducing the risk of human anti-human antibodies through v gene manipulation The present embodiments relate to methods of identifying and creating human, or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for ... 11/24/05 - 20050260678 - Method of diagnosing nephrotic syndrome This invention provides organic biomolecule markers (e.g., proteins) useful for differentiating minimal change nephrotic syndrome (MCNS) from focal segmental glomerulosclerosis (FCS), membranous nephrothropy (MN), and membranoproliferative glomerulonephritis (MPGN). This invention also provides organic biomolecule markers useful for evaluating the therapeutic value of agents for treating kidney disease. ... 11/24/05 - 20050260677 - Enhanced waveguide and method The present invention provides an optical assay apparatus that includes a light source module and an optical sensor. The light source module produces light having a range of propagation angles. The sensor includes a light adjusting portion and an assay sensing portion. The light adjusting portion receives the light produced ... 11/17/05 - 20050255528 - Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached ... 11/17/05 - 20050255527 - Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule The invention is directed to a cross-screening system and methods of the invention utilizing a combination of an immunoassay (IA) and electrochemiluminescence assay (ECLA) to identify molecules that have binding affinities for a target molecule. The cross-screening system and methods of the invention can detect molecules that have binding affinities ... 11/17/05 - 20050255526 - Anti-tag antibody chip for protein interaction analysis It is an object of the present invention to conduct function analysis of proteins arranged with high density on a solid phase in a high-throughput manner, regardless of protein varieties. The present invention is characterized in that it immobilizes target proteins on a substrate while maintaining the structures and the ... 11/17/05 - 20050255525 - Safe method for isolation of prion protein and diagnosis of transmissible spongiform encephalopathies Provided is a safe novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a sample from a subject to determine whether the subject has transmissible spongiform encephalopathy; and detecting abnormal prion protein (Prpes) in the sample. The method detects PrPres without Proteinase-K treatment by disrupting the sample ... 11/10/05 - 20050250160 - Methods and compositions using stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed ... 11/10/05 - 20050250159 - Methods for using raman spectroscopy to obtain a protein profile of a biological sample The invention provides methods for analyzing the protein content of a biological sample, for example to obtain a protein profile of a sample provided by a particular individual. The proteins and protein fragments in the sample are separated on the basis of chemical and/or physical properties and maintained in a ... 11/10/05 - 20050250158 - Arrays of colloidal crystals The present invention is directed to arrays of colloidal crystals and method of using such arrays to detect analytes in a sample. ... 11/10/05 - 20050250157 - Method and device for the selective withdrawal of components from complex mixtures The method according to the invention permits a selected withdrawal of one or a few molecularly disperse or cellular components of a system, such as molecules, molecular complexes, vesicles, micelles, cells, optionally together with an associated volume element V having a size of 10−9 l≧V≧10−18 l from a larger sample ... 11/10/05 - 20050250156 - Detection of acute myocardial infarction biomarkers The present invention relates to medical devices and methods for early detection of acute myocardial infarction in a patient. In particular, the invention relates to a device and method for detecting the presence of biomarker analytes in a specimen which are indicative of a potential acute myocardial infarction in the ... 11/03/05 - 20050244893 - Novel method for determination of plasminogen activator inhibitor The invention provides a novel assay system for measuring the amount of active PAI-1 in a sample with sensitivity, and correlation to an active PAI-1 amount. The assay determines the amount of active PAI-1 in a sample by utilizing a novel standard curve. It is emphasized that this abstract is ... 11/03/05 - 20050244892 - Resistin as a marker and therapeutic target for cardiovascular disease The risk or progression of cardiovascular disease and coronary artery disease is assessed in a mammalian subject by measuring the level or concentration of circulating serum resistin in a subject and comparing the measured level to resistin levels within a standardized or standard population. Methods of treating cardiovascular diseases and/or ... 11/03/05 - 20050244891 - Ligand-containing micelles and uses thereof Ligand-containing micelles and various compositions, kits and methods for their preparation and use are provided. ... 11/03/05 - 20050244890 - Biomarkers for alzheimer's disease The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. ... 11/03/05 - 20050244889 - Transcription factor coactivator protein, p/cip The present invention provides a substantially purified nucleic acid molecule encoding a p/CIP polypeptide, which regulates the activity of CBP/p300-dependent transcription factors. The invention also provides a substantially purified p-CIP polypeptide and active fragments thereof. In addition, the invention provides methods of identifying an effective agent that alters the association ... 11/03/05 - 20050244888 - Antibodies to human chemokine beta-9 Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such ... 10/27/05 - 20050239142 - Assay method for group transfer reactions The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer reactions. The invention further provides immunoassays, antibodies and kits that may be used to practice the methods of the invention. ... 10/27/05 - 20050239141 - Modified antibody variable domains Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a hereterologous species and for preparing so modified antibody variable domains which are useful for ... 10/27/05 - 20050239140 - Solution phase biopanning method using engineered decoy proteins The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains the targeted domain or epitope. The invention is based ... 10/27/05 - 20050239139 - Transmissible spongiform encephalopathy test reagents and methods The invention provides improved methods and compositions for selectively binding and/or detecting an aggregating abnormal form of a protein in the presence of non-aggregating normal form of the protein. ... 10/27/05 - 20050239138 - Use of cardiac hormones to assess risk of cardiovascular complication from volume overload The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for assessment of risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of intravasal volume overload. In particular, the invention relates to a method for diagnosing the risk of ... 10/27/05 - 20050239137 - Assay for carbohydrate-free transferrin The present invention provides a method for the determination of carbohydrate-free transferrin in a body fluid for use in the assessment of alcohol consumption, the method comprising (a) contacting a sample of the body fluid with a carbohydrate-binding ligand, to bind any carbohydrate or carbohydrate-containing moieties in the sample to ... 10/27/05 - 20050239136 - Risk markers for cardiovacular disease Provided herein methods for determining whether a subject, particularly a human subject, is at risk of developing, having, or experiencing a complication of cardiovascular disease, and methods of treating subjects who are identified by the current methods of being at risk for cardiovascular disease. In one embodiment, the method comprises ... 10/27/05 - 20050239135 - Compositions, methods and kits for biarsenical fluorophore labeling Methods, compositions, and kits for labeling tetracysteine-tagged proteins with biarsenical fluorophores with increased specificity, including compositions, methods and kits particularly adapted for labeling of tetracysteine-tagged proteins to be resolved within an electrophoresis gel. ... 10/27/05 - 20050239134 - Combinatorial selection of phosphorothioate single-stranded dna aptamers for tgf-beta-1 protein The present invention includes the selection and isolation of thioaptamers that target the signaling protein TGF-β1, compositions of such thioaptamers and the use of such thioaptamers to either block or enhance signal transduction of the TGF-β1 protein and thus function as, e.g., immunomodulatory agents. Thioaptamers may also be targeted alone ... 10/27/05 - 20050239133 - Methods to identify true antagonists and inverse agonists of the cannabinoid receptor The present invention relates to a method to identify a true antagonist and an inverse agonist of a cannabinoid receptor (CB), and to discriminate between them. The invention further relates to the use of these true antagonists and inverse agonists in the treatment of CB associated disorders such as obesity, ... 10/27/05 - 20050239132 - Method and device for determining a concentration of ligands in an analysed sample The invention relates to a method for determining a concentration of ligands in an analyzed sample. The inventive method consists in immobilizing receptors specifically boundable with said ligands on a support. At least one measured value of the occupation of the support surface by the receptors is determined by means ... 10/20/05 - 20050233382 - Polypeptide variants with altered effector function The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof. ... 10/20/05 - 20050233381 - Evolving new molecular Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of ... 10/20/05 - 20050233380 - High throughput discovery of materials through vapor phase synthesis A method of and apparatus for producing a plurality of powder compositions, both stoichiometric and non-stoichiometric, is disclosed. The method includes the steps of introducing a plurality of materials into a particle production system under a first set of operating parameters, introducing the plurality of materials into the particle production ... 10/20/05 - 20050233379 - Methods of antagonizing morphogens Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding ... 10/20/05 - 20050233378 - Biosensor wherein X represents a group capable of binding to the surface of a biosensor or a functional group existing on the surface of the biosensor; Y represents a group capable of binding to a physiologically active substance or a compound binding to the physiologically active substance; Z represents a group ... 10/20/05 - 20050233377 - Drug screening method for the treatment of brain damage NMR spectroscopy is used as an efficient and effective rapid screening method for identifying compounds that interact with PSD-95. This method includes the steps of taking a first NMR spectrum of a sample of free PDZ2; mixing a test compound with said sample of free PDZ2 to form a test ... 10/13/05 - 20050227294 - Molecular modification assays involving lipids Assays for detecting molecular modifications, such as phosphorylation, dephosphorylation, and/or cleavage, among others, of lipids, lipid fragments, and/or lipid precursors. These assays may be used to detect the presence and/or activity of enzymes and/or other agents, such as drugs, involved in facilitating, inhibiting, and/or otherwise regulating such modifications. ... 10/13/05 - 20050227293 - Styryl dyes with linker A combinatorial library of solid-state fluorescent dyes is prepared by reacting an aldehyde with a solid-supported pyridinium salt having a linker. ... 10/13/05 - 20050227292 - Allergenic protein complex of natural rubber latex The invention relates to the allergenic latex protein Hev b 4. The full cDNA sequence of the smaller protein components of Hev b 4 is disclosed, together with the amino acid sequence of those components and the synthesis of a recombinant protein using the aforesaid DNA sequence or a synthetic ... 10/13/05 - 20050227291 - Heterocyclic compounds containing a nine-membered carbon-nitrogen ring The present invention provides heterocyclic compounds having a nine-membered ring of three repeating C—C—N subunits covalently bound to each other through amide bonds, and variable side groups linked to a central C of each subunit. Also described herein are cells containing the cyclic compounds, methods of screening those cells to ... 10/13/05 - 20050227290 - Novel coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same The present invention provides novel coordination complexes, methods for synthesizing and identifying coordination complexes using combinatorial techniques, and assaying for their activity. In certain embodiments, the subject coordination complexes contain platinum. ... 10/13/05 - 20050227289 - Antibodies to erythropoietin receptor and uses thereof The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a ... 10/13/05 - 20050227288 - Synthesis and application of procainamide analogs for use in an immunoassay and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding ... 10/13/05 - 20050227287 - Chaperones capable of binding to prion proteins and distinguishing the isoforms prpc and prpsc The present invention relates to methods for the detection or isolation of prion proteins by use of chaperones specifically binding to said proteins. The invention further relates to a method for in-vitro diagnosis of a transmissible spongiform encephalopathy and to pharmaceutical compositions, preferably for the prevention or treatment of said ... 10/06/05 - 20050221390 - High quantum yield acridinium compounds and their uses in improving assay sensitivity The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it ... 10/06/05 - 20050221389 - Organic reactions with co generating materials The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to ... 10/06/05 - 20050221388 - Molecular interactions in hematopoietic cells The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells. ... 10/06/05 - 20050221387 - Fluorescence analysis method using fluorescent-activating antibodies An object of this invention is to provide a fluorescence analysis method that enables analysis (including imaging) of in vivo substances, etc., using antigen-antibody reactions to be carried out simply, at high sensitivity, and yet continuously and in real time. This invention's fluorescence analysis method comprises: a mixing step of ... 10/06/05 - 20050221386 - Chromatographic exclusion agglutination assay and methods of use thereof The present invention relates to agglutination assays and in particular to chromatographic exclusion assays and methods of use thereof The present invention includes a novel strategy for determining the presence of one or more analytes on interest in a test sample by using chromatographic exclusion of aggregates of bound detectable ... 10/06/05 - 20050221385 - Pressure based mobility shift assays Methods for chromatographically separating materials, including the separation of materials in kinase or phosphatase assays, in microfluidic devices under positive or negative fluid pressure. Devices and integrated systems for performing chromatographic separations are also provided. ... 10/06/05 - 20050221384 - Combinatorial libraries of monomer domains Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or ... 10/06/05 - 20050221383 - Osteoarthritis biomarkers and uses thereof The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The biomarkers of the invention may ... 10/06/05 - 20050221382 - Stratification of patient populations having or suspected of having rheumatoid arthritis The present disclosure is directed to screening, diagnosing and treating patients having, or suspected of having, rheumatoid arthritis. Levels of glucose-6-phophate isomerase or antibodies to glucose-6-phophate isomerase are assayed in test subjects or populations to determine susceptibility to, or existence of, an antibody mediated form of rheumatoid arthritis in such ... 10/06/05 - 20050221381 - Method for isolating ligands Described is a method for isolating ligands which have a binding capacity to a MHC/HLA molecule or a complex comprising said ligand and said MHC/HLA molecule which method comprises the following steps:—providing a pool of ligands, said pool containing ligands which bind to said MHC/HLA molecule and ligands which do ... 10/06/05 - 20050221380 - Method for determination of the responsiveness of an individual to mistletoe lectin A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for mistletoe lectin is characteristic of a corresponding responsiveness. ... 09/29/05 - 20050214869 - Molecular interactions in hematopoietic cells The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells. ... 09/29/05 - 20050214868 - Multi-partite ligands and methods of identifying and using same The invention provides methods for generating a library of bi-ligands, comprising (a) determining a common ligand to a conserved site in a receptor family; (b) attaching an expansion linker to the common ligand, wherein the expansion linker has sufficient length and orientation to direct a second ligand to a specificity ... 09/29/05 - 20050214867 - Prion protein standard and method of making same The invention provides prion protein standards for use as reference materials for prion detection. The standard may be species specific, i.e. the standard is comprised of a preparation for detection of a single strain prion or it may be prepared to allow detection of multiple prion strains simultaneously. The invention ... 09/29/05 - 20050214866 - Detection of allergen-specific ige This invention relates to point-of-care devices and methods to screen animals with suspected IgE-mediated allergic disease. The present invention provides a simple and rapid preliminary immunoassay screen, in which a defined mixture of clinically relevant allergens is used to capture allergen-specific IgE present in a sample, followed by a second ... 09/29/05 - 20050214865 - Changeable machine readable assaying indicia A machine readable assaying system comprising a test card having machine readable assaying means. A plurality of individual analysis strips, each strip comprising antibodies and/or reagents capable of indicating the positive presence of distinct illicit substances form a pattern of elements including one or more fixed strips and one or ... 09/29/05 - 20050214864 - Nphp nucleic acids and proteins The present invention relates to Nephronophthisis, in particular to the NPHP5 protein (nephrocystin-5) and nucleic acids encoding the NPHP5 protein. The present invention also provides assays for the detection of NPHP5 polymorphisms and mutations associated with disease states. ... 09/29/05 - 20050214863 - Method and system for the analysis of saliva using a sensor array A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically ... 09/29/05 - 20050214862 - Diagnosis of spongiform disease A diagnostic test is provided for testing for spongiform encephalopathy and other demyelinating conditions in mammals such as BSE in cattle, and MS or CJD in humans, by assaying antibodies present in the mammal which bind to an Acinetobacter species containing an antigenic peptide which exhibits molecular mimicry of a ... 09/29/05 - 20050214861 - Human hematopoietic stem and progenitor antigen and methods for its use A hematopoietic progenitor cell antigen and reagents, notably antibodies, that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult ... 09/29/05 - 20050214860 - Antibodies specific to kdr and uses thereof The invention provides an immunoglobulin molecule which binds KDR with an affinity comparable to human VEGF, and that neutralizes activation of KDR. Immunoglobulin molecules include monovalent single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, antibodies, humanized antibodies and chimerized antibodies. The invention further provides nucleic acid molecules that encode ... 09/29/05 - 20050214859 - Peptides that specifically bind hgf receptor (cmet) and uses thereof A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed. ... 09/29/05 - 20050214858 - Novel 35 kd protein It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar ... 09/29/05 - 20050214857 - Method for displaying loops from immunoglobulin domains in different contexts The present invention is related to an isolated polypeptide micro-scaffold displaying immunoglobulin CDR2 or CDR3 polypeptide sequences, comprising a CDR2 or CDR3 polypeptide sequence interconnecting fragments of the adjacent framework polypeptide sequences, which are arranged to form two anti-parallel β-strands. The present invention is further related to a method to ... 09/22/05 - 20050208593 - Lateral flow diagnostic assay reader with radial cassette The present invention provides a method and field portable apparatus for analyte detection using lateral flow immunochromatographic assays, where a single test sample may be simultaneously applied to multiple assays. ... 09/22/05 - 20050208592 - Method and apparatus for the detection of microorganisms The present application discloses a method for detecting a viable microorganism in a sample. The method may comprise (i) providing a detecting electrode and a counter electrode, (ii) contacting said sample with said detecting electrode and said counter electrode and (iii) measuring a difference in impedance between said detecting electrode ... 09/22/05 - 20050208591 - Antibodies to chemokine alpha-6 The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention ... 09/22/05 - 20050208590 - Assays for diagnosis of thrombophilic disease The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding of an anticoagulant protein, annexin, preferably annexin-V, to phospholipids by antiphospholipid (aPL) antibodies in ... 09/22/05 - 20050208589 - Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof Branched peptide amphiphilic compounds incorporating one or residues providing a pendant amino group for coupling one or more epitope sequences thereto, such compounds and related compositions for enhanced epitope presentation. ... 09/22/05 - 20050208588 - Supports for oligomer synthesis Universal linkers, their facile processes of manufacture and methods of using the same are provided. ... 09/22/05 - 20050208587 - Peptides that bind to broadly neutralizing anti-hiv antibody-structure of 4e10 fab fragment complex. uses thereof, compositions therefrom The present invention relates to the structure of Fab 4E10, e.g., as a complex with herein identified peptide KGND, herein identified as a 4E10 mimetope on gp41, as determined by crystallographic techniques, and the confirmation that peptide KGND has a functional relevant conformation, as well as the determination of key ... 09/22/05 - 20050208586 - Using complement component c1q derived molecules as tracers for fluorescence polarization assays The present invention relates to polypeptides or non-polypeptides derived from C1q, a subunit of the first complement component molecule C1. These molecules bind to the C1q receptor on the Fc domain of an antibody in immune complexes (also called antigen-antibody complexes or aggregated immunoglobulins), but do not bind to free ... 09/22/05 - 20050208585 - Agonist antibodies Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia. ... 09/22/05 - 20050208584 - Chemokine-binding protein and methods of use Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine-binding domain of a THAP-family polypeptide. Also disclosed are methods of binding chemokines, inhibiting the activity of chemokines, detecting chemokines, and reducing the symptoms associated with a chemokine mediated or influenced condition by ... 09/22/05 - 20050208583 - Detection of autoantibodies to cytokeratin 18 protein in patients with bronchial asthma and chronic rhinitis, and its applications including a kit for diagnosing bronchial asthma and chronic rhinitis comprising mammalian cytokeratin 18 protein The present invention is based on the surprising discovery of autoantibodies to cytokeratin 18 protein in the serum samples of patients with bronchial asthma and chronic rhinitis, especially in nonallergic patients. The present invention includes diagnostic methods and a diagnostic kit to detect patients with bronchial asthma and chronic rhinitis ... 09/22/05 - 20050208582 - Pyrazole compounds and pharmaceutical compositions comprising the compound V each independently designate the formula -L-X—Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, ... 09/15/05 - 20050202512 - Method to screen phage display libraries with different ligands The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of binding functional members of the repertoire regardless of ... 09/15/05 - 20050202511 - Amp-activated protein kinase (ampk) inhibitor screening assay The present invention relates to methods for screening for agents that bind to and modulate the cystathionine â-synthase domains of the γ subunit such as are found on AMP-activated protein kinase (AMPK. Such agents which bind AMPK are candidates for use in the treatment of for example: diabetes, obesity, hyperlipidaemia ... 09/15/05 - 20050202510 - Method for identifying a site of protein-protein interaction for the rational design of short peptides that interfere with that interaction The invention provides a method for identifying a site of protein-protein interaction in a polypeptide. In general, the method involves calculating the difference in property scores between amino acids of a corresponding pair of amino acids on two homologous polypeptides, and identifying a window of contiguous amino acids that have ... 09/15/05 - 20050202509 - Reagent for measuring clotting time and method for measuring clotting time The present invention provides a reagent for measuring clotting time that allows accurate analysis of blood coagulation in samples containing antiphospholipid antibodies, wherein the clotting time is measured by using a sample containing an antiphospholipid antibody, a causative substance of antiphospholipid antibody syndromes, and the reagent for measuring clotting time ... 09/15/05 - 20050202508 - Biomarker for parkinson's disease This invention provides methods for assessing the likelihood that a patient is suffering from Parkinson's disease by detecting a biomarker in a sample from the patient. This invention also provides diagnostic kits for the same. ... 09/15/05 - 20050202507 - Diazaphosphacycles Diazaphosphacycles comprising compounds having the formula XI and salts of the compound are provided, wherein the variables W, T, R1, R14, and R15 are as described herein. Transition metal catalysts incorporating such diazaphosphacycles and methods of use thereof are also disclosed. There are further provided compositions comprising diazaphosphacycles covalently attached ... 09/15/05 - 20050202506 - Methods for identifying and producing specific amino acid dependent antibodies and uses thereof The present invention relates to methods for identifying and producing amino acid dependant antibodies to specific ligands and uses thereof. ... 09/15/05 - 20050202505 - Method to identify modulators for human 3alpha-hydroxysteroid dehydrogenase 3 α-hydroxysteroid dehydrogenase (3a-HSD) plays a central role in the metabolism and action of steroid hormones and neurosteroids (steroids synthesized in the central nervous system). The high resolution structure of human type III 3a-HSD crystallized in complex with cofactor NADP is determined by X-ray diffraction. Furthermore the active site is ... 09/08/05 - 20050196813 - Heterocyclic sulfonamide inhibitors of beta amyloid production wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described ... 09/08/05 - 20050196812 - Determining the estimated date of embryo implantation and related dates A method of determining the estimated date of implantation of an embryo may include testing a sample of a body fluid from a pregnant human female subject so as to obtain data indicative of the concentration of human chorionic gonadotrophin (hCG) in the sample, and calculating an estimated date of ... 09/08/05 - 20050196811 - Peptide identification The present invention provides a peptide identification method along with related peptide databases, method of generating the databases, computer usable media, and computer program products. The peptide identification method involves the use of qualitative amino acid composition or partial qualitative amino acid composition information of a query peptide obtained by ... 09/08/05 - 20050196810 - Hairpin peptides with a novel structural motif and methods relating thereto The invention is directed to a model system for structure-activity relationship analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising peptides with a novel “tryptophan zipper” scaffold (trpzip) that forms stable β-hairpin structure in solution. Methods of selecting and ... 09/08/05 - 20050196809 - Identification and characterization of proteins using new database search modes A method of selecting a set of candidate polypeptides for a sample polypeptide that includes a first refining of a collection of candidate polypeptides from differences in mass of fragments of the sample polypeptide produced by mass spectrometry and a second refining of the collection of candidate polypeptides from the ... 09/08/05 - 20050196808 - Products and processes for modulating peptide-peptide binding domain interactions The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The ... 09/01/05 - 20050191708 - Microwave microfluidics The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these ... 09/01/05 - 20050191707 - Methods for identifying or screening for agents that modulate 17beta-hsd3 Methods for determining whether a test agent inhibits a 17β-HSD3, said methods comprising: obtaining a recombinant host cell that expresses said 17β-HSD3; obtaining a reaction mixture comprising said 17β-HSD3, androstenedione, and said test agent; measuring the amount of testosterone in said reaction mixture by a scintillation proximity assay (SPA) using ... 09/01/05 - 20050191706 - Universal peptide-binding scaffolds and protein chips The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated with a disease state) or can represent the entire proteome. The target can be either protein fragments prepared by enzymatic ... 09/01/05 - 20050191705 - High throughput screening using fluorophore labeled lipid membranes and fluorescence correlation spectroscopy An apparatus for and method of detecting a binding event between biomolecules is disclosed and includes admixing a target molecule including a first fluorophore and membrane vesicles including a trifunctional linker molecule, said trifunctional linker molecule including a second fluorophore, to form a sample, introducing a library of elements into ... 09/01/05 - 20050191704 - Assay devices utilizing chemichromic dyes An assay device for detecting amines within a test sample (e.g., vaginal fluid) is provided. The assay device comprises a detection zone within which a chemichromic dye is contained. The chemichromic dye is capable of undergoing a color change upon exposure to one or more amines within the test sample. ... 09/01/05 - 20050191703 - Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for ... 09/01/05 - 20050191702 - Antibody and chemokine constructs and their use in the treatment of infections of immunological diseases The invention is directed to chimeric polypeptides, e.g., bispecific antibodies, comprising a chemokine receptor binding domain and a T cell surface polypeptide or cell toxin binding domain, nucleic acids that encode them, and methods of making and using them. The chimeric polypeptides of the invention can include, be bound to, ... 08/25/05 - 20050186638 - Method for the screening of alpha2beta-1 subunit binding ligands A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides. ... 08/25/05 - 20050186637 - Neutrokine-alpha and neutrokine-alpha splice variant The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically ... 08/25/05 - 20050186636 - Method of rational-based drug design using osteocalcin The invention relates to a method of identifying a compound that affects osteocalcin activity, comprising obtaining a 3D structure of osteocalcin or a fragment thereof, designing a compound to interact with, or mimic, the 3D structure of osteocalcin or fragment thereof, obtaining the compound, and determining whether the compound affects ... 08/25/05 - 20050186635 - Electroactive surface-confinable molecules The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents that affect the oxidation/reduction potential (redox potential) of the species. By controlling the redox potential of ... 08/25/05 - 20050186634 - Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by ... 08/25/05 - 20050186633 - In vitro gastrointestinal model system and uses thereof A system utilizing cell immobilization in anaerobic continuous-flow cultures for modelling the gastrointestinal system is described. Microbial cells derived from flora, e.g. in fresh faecal samples, are used as the source of inocula for immobilisation in a mixed gel of gellan and xanthan. The beads produced are then introduced in ... 08/18/05 - 20050181456 - Methods for determining the amount of peptide yy in blood A method for determining the total amount of a Y2 receptor-binding such as PYY in a blood sample. Bound PYY is first freed from components in the blood and proteinaceous material in the blood precipitated preferably by the addition of an organic solvent miscible in water such as ethanol. The ... 08/18/05 - 20050181455 - Generation of combinatorial synthetic libraries and screening for novel proadhesins and nonadhesins One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present invention relates to combinatorial libraries of the aforementioned compounds. The present invention also relates to compositions comprising a compound ... 08/18/05 - 20050181454 - Synthesis of template-fixed beta-hairpin loop mimetics Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is ... 08/18/05 - 20050181453 - Ubiquitin-based protein interaction assays and related compositions The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins. ... 08/18/05 - 20050181452 - Fragment complementation assays for g-protein-coupled receptors and their signaling pathways This invention relates generally to the fields of biology, molecular biology, chemistry and biochemistry. The invention is directed to a large number of novel assays for G-protein-coupled receptors (GPCRs) and their signaling pathways. Methods are described for constructing such assays for one or more steps in a GPCR pathway. The ... 08/18/05 - 20050181451 - Detection of asymptomatic coronary artery disease using atherogenic proteins and acute phase reactants A method of assessing the likelihood that a person who is asymptomatic for coronary artery disease does in fact have the disease is disclosed. The levels of an atherogenic protein and acute phase reactant and optionally of anti-atherogenic protein for an individual are obtained and compared to one or more ... 08/18/05 - 20050181450 - Novel inositol 1,4,5-trisphosphate (ip3) receptor-binding protein and an ip3 indicator The present invention provides a novel IP3 receptor-binding protein that is used as an indicator effective for detecting and quantifying IP3, and a method for detecting and/or quantifying IP3 using the same. Determined is an IP3 receptor-binding protein, particularly a novel IP3 receptor-binding protein, IRBIT, which interacts with an IP3 ... 08/18/05 - 20050181449 - Arrays and methods Arrays of cytosolic accessory proteins are provided, together with methods of screening, using such arrays. ... 08/18/05 - 20050181448 - Biological products There are disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the ... 08/18/05 - 20050181447 - Opioid metallopeptide compositions and methods Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one ... 08/18/05 - 20050181446 - Protein variants having modified immunogenicity The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids ... 08/11/05 - 20050176067 - Biosensor for determining an allergen with operating procedures A biosensor is for detecting an allergen-specific immunoglobulin E (IgE) via antigen/antibody coupling. The biosensor includes a silicon substrate and at least one interdigital electrode pair structure applied to the silicon substrate with a gap between the electrode pairs of a maximum of 1.0 μm. A counter electrode is further ... 08/11/05 - 20050176066 - Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use. ... 08/11/05 - 20050176065 - Target sequences for synthetic molecules The invention is based on the discovery that certain biarsenical molecules react with specified target sequences, thereby providing a facile means for labeling polypeptides containing the target sequence. The invention is useful in creating stable mammalian cell lines expressing a certain tetracysteine tagged polypeptides, thereby overcoming toxicity associated with native ... 08/11/05 - 20050176064 - Method for determining the number of receptors on a carrier The invention relates to a method for determining the number of receptors on a carrier, in addition to a biosensor, especially a protein sensor, which can be produced using the method. ... 08/11/05 - 20050176063 - Immunoreaction measurement method The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids having a hydroxyl group, dicarboxylic acids having a double ... 08/11/05 - 20050176062 - Method of identifying ligands for nuclear receptors The present invention provides a method of identifying a ligand to a nuclear receptor protein comprising wherein said nuclear receptor protein is first expressed in an eukaryotic expression system in the presence of at least one candidate ligand. The nuclear receptor protein is then purified, isolated and mass spectrometry is ... 08/11/05 - 20050176061 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and ... 08/11/05 - 20050176060 - Crystal structure Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argininc deliminase (DI) or a fragment thercof to X-ray diffraction measurements and deducing the structural coordinales from the diffraction measurements arc used to identify, screen, characteristic, design or modify a chemical entity. ... 08/11/05 - 20050176059 - Bio-safe dispenser and optical analysis disc assembly A liquid sample dispenser for use with an optical analysis disc. The dispenser includes a body portion, a tip portion connected to the body portion, first and second retainer members moveably supported within the tip portion, and a sealant contained between the first and second retainer members. One of the ... 08/04/05 - 20050170432 - Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... 08/04/05 - 20050170431 - Pyk2 crystal structure and uses A crystal structure of PYK2 is described that was determined by X-ray crystallography. The use of PYK2 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PYK2. ... 08/04/05 - 20050170430 - Diagnosis and treatment of glaucoma and methods for discovering new glaucoma therapeutic agents based on the wnt/ca2+ signaling pathway The present invention provides methods for diagnosing and treating glaucoma and identifying agents potentially useful for treating glaucoma. The invention further provides compositions useful for treating glaucoma. ... 08/04/05 - 20050170429 - Method for monitoring collagen type ii degradation in cartilage A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals ultizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope ... 08/04/05 - 20050170428 - Enhanced inserted yellow fluorescence protein and its application Disclosed are mutated genes for green fluorescence proteins and enhanced inserted YFPs expressed therefrom. The mutant proteins not only maintain their fluorescence even at 37° C., but also exhibit about 20 times stronger fluorescence intensities in comparison to the conventional fluorescence proteins. Accordingly, the mutant fluorescence proteins of the present ... 07/28/05 - 20050164304 - Infrared spectroscopic imaging of libraries Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with ... 07/28/05 - 20050164303 - Specific-c-peptide assay method The present invention relates to a specific C-peptide assay method which can eliminate all interference due to proinsulin and its intermediates, in particular des-31,32-proinsulin and/or des-64,65-proinsulin. It also relates to antibodies for carrying out this assay. ... 07/28/05 - 20050164302 - Analyzing and typing monoclonal proteins by capillary electrophoresis and immunodisplacement The invention concerns a method for capillary electrophoretic analysis of a biological sample, comprising using negatively surcharged modified antibodies so that they migrate to a zone located outside the migration zone for proteins from the biological sample when they are separated during electrophoresis, said antibodies having antigenic specificity for a ... 07/28/05 - 20050164301 - Ldl receptor class a and egf domain monomers and multimers Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention. ... 07/28/05 - 20050164300 - Molecular scaffolds for kinase ligand development Molecular scaffolds for compounds active on protein kinases are described, along with methods for using such scaffolds for kinase ligand development. The use of kinase structural information, exemplified with PIM-1 crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to ... 07/28/05 - 20050164299 - Phase change sensor A device is disclosed which is a highly sensitive and selective sensor. The device is comprised of a sensor material secured into a fixed position on substrate, a deformable arm and a signaling component which creates a detectable signal in response to movement of the arm. The sensitivity of the ... 07/28/05 - 20050164298 - Diagnostics and therapeutics for diseases associated with growth hormone secretagogue receptor(ghs) The invention provides a human GHS which is associated with the cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, hematological diseases, cancer, gastro-intestinal diseases and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention ... 07/28/05 - 20050164297 - Novel catalysts and processes for their preparation Accordingly, in an aspect of the invention, and not necessarily the broadest aspect, there is provided a hybrid homogeneous-heterogeneous catalyst containing catalytic groups, wherein the catalytic activity of the catalyst is largely provided as a result of the interaction of catalytic groups in a suitable proximity and disposition to other ... 07/28/05 - 20050164296 - Catalysts A tethered ligand comprising the reaction product of an organofunctional silica and a ligand containing a functional group capable of reaction with said organofunctional silica, wherein the organofunctional silica is prepared from an alkyl silicate and an organofunctional silane is described. A supported catalyst is also described comprising additionally a ... 07/28/05 - 20050164295 - Screen for selective inhibitors or activators of smad protein function A method of screening for selective inhibitors or activators Smad protein function is disclosed. In one embodiment, the invention comprises the steps of (a) obtaining a phosphorylated Smad protein or protein complex, (b) allowing the phosphorylated Smad protein or complex to interact with a target protein or peptide in the ... 07/21/05 - 20050158798 - Production of consumable alcohols and components thereof The invention is directed to a process for producing consumable alcohols and components thereof, in particular for producing consumable alcohols and components thereof using high throughput rapid screening and production of combinatorial libraries of consumable alcohols and components. In particular, the consumable alcohol is wine, Scotch, cognac, ports, beer, gin, ... 07/21/05 - 20050158797 - Mammalian cdp-diacylglycerol synthase There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of ... 07/21/05 - 20050158796 - Use of a tag to enrich polypeptides libraries The invention is directed to production of chimeric antibodies using display screening methods. The invention is based in part on two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display libraries for members displaying more than one copy of a polypeptide prior ... 07/21/05 - 20050158795 - Antibody and use thereof The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other ... 07/21/05 - 20050158794 - Luminescent markers The invention relates to luminescent proteins, nucleic acids encoding same, compositions and combinations comprising the proteins, and methods using the proteins, nucleic acids, compositions and combinations. In particular, a luminescent protein is provided comprising oncomodulin in which a salt bridge has been introduced to provide greater stability. The protein may ... 07/21/05 - 20050158793 - Immunoassays This invention provides a method wherein a protein sparingly soluble in water, or a protein in a hardly extractable state, is detected sharply and easily in subsequent immunoreaction while high efficiency of extraction from a sample is maintained. Disclosed is a highly sensitive and easy immunoassay characterized in that a ... 07/14/05 - 20050153366 - Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described ... 07/14/05 - 20050153365 - 1, 2-dioxetane derivatives and reagents employing them wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling ... 07/14/05 - 20050153364 - Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks The present invention determines properties of combinatorial library products from features of library building blocks. At least one feature is determined for each building block of a combinatorial library having a plurality of products. A training subset of products is selected from the products, and at least one property is ... 07/14/05 - 20050153363 - Polymer arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources. ... 07/14/05 - 20050153362 - Polymer arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources. ... 07/14/05 - 20050153361 - Therapeutic and diagnostic applications of protein disulphide isomerases An endothelial form of protein disulphide isomerase (endoPDI) is specifically upregulated in endothelial cells in response to hypoxia. Inhibition of endoPDI expression in hypoxic cells induces apoptosis. Thus the invention provides the use of endoPDI as a marker for angiogenesis and as a therapeutic target for the inhibition of angiogenesis. ... 07/14/05 - 20050153360 - Diagnostic method for stroke The present invention provides a method of diagnosis of stroke or the possibility thereof in a subject suspected of suffering from stroke, comprising subjecting a sample of body fluid taken from the subject to mass spectrometry to determine a test amount of a polypeptide in the sample, wherein the polypeptide ... 07/14/05 - 20050153359 - Method for the evaluation of velvet antler The invention provides a method and apparatus using infrared thermography for predicting an unknown value of an internal composition characteristic of velvet antler in vivo, in vitro, and/or during cooling or warming. The method involves generating a predictive model using a sample population of antlers to determine a relationship between ... 07/14/05 - 20050153358 - High-throughput screening method for determining the enantioselectivity of catalysts, biocatalysts, and agents The invention relates to a high-throughput screening method based on NMR spectroscopy for determining the enantioselectivity of reactions which show an asymmetric course. The reactions can be caused by chiral catalysts, agents, or biocatalysts such that said products can be evaluated regarding the enantioselectivity thereof. In one embodiment, isotope-marked pseudo-enantiomers ... 07/07/05 - 20050148030 - Inhibition of immune complex formation Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation, are described. ... 07/07/05 - 20050148029 - Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or ... 07/07/05 - 20050148028 - Scaffolded fusion polypeptides and compositions and methods for making the same The present invention provides soluble forms of integral membrane proteins, or domains or portions thereof, that retain the biological activity of the integral membrane protein, domain or portion from which they are designed or derived and that can readily be expressed in high yield. ... 07/07/05 - 20050148027 - Very large scale immobilized polymer synthesis A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to ... 07/07/05 - 20050148026 - Biomarkers for amyotrophic lateral sclerosis The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, ... 07/07/05 - 20050148025 - Differential diagnosis with hepcidin The present invention concerns the use of hepcidin as a marker for detecting inflammatory chronic diseases and especially for a differential diagnosis to detect inflammatory chronic diseases and/or non-inflammatory chronic diseases. The present invention also concerns a method for detecting inflammatory chronic diseases, non-inflammatory chronic diseases and/or acute phase reactions ... 07/07/05 - 20050148024 - Methods and compositions for measuring natriuretic peptides and uses thereof The present invention describes compositions and methods designed to determine the presence or amount of natriuretic peptides, or their fragments, in a sample. The degradation of natriuretic peptides is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic ... 07/07/05 - 20050148023 - Screening for gestational disorders The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy, and as early as the first trimester. ... 07/07/05 - 20050148022 - Assay The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand ... 07/07/05 - 20050148021 - Process for the selective alkylation of-sh groups in proteins and peptides for the study of complex protein mixtures Weakly basic molecules containing a double bond (in particular vinylpyridines) are able to react and selectively alkylate —SH groups in proteins, thus preventing their re-oxidation to disulphur bridges. Contrary to conventional alkylating agents, such as iodoacetamide, such molecules reach 100% alkylation of all —SH residues, even in complex proteins, without ... 06/30/05 - 20050142615 - Immunization of dairy cattle with chimeric gapc protein against streptococcus infection The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC ... 06/30/05 - 20050142614 - Methods for ligand discovery The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed “tethering” where potential ligands are covalently bonded or “tethered” to a target and subsequently identified. ... 06/30/05 - 20050142613 - Test for the rapid evaluation of ischemic states and kits The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin ... 06/30/05 - 20050142612 - Inhibitors of amyloid precursor protein processing The application discloses inhibitors of amyloid precursor protein (APP) processing which bind to β-secretase and/or γ-secretase cleavage sites. ... 06/30/05 - 20050142611 - Method of isolation and self-assembly of small protein particles from blood and other biological materials Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation ... 06/30/05 - 20050142610 - Variant polypeptides containing plekstrin homology domains and uses therefor The instant invention provides polypeptides comprising variant pleckstrin homology (PH) domains. The invention provides polypeptides having increased or decreased binding specificity for a phosphatidylinositide molecule to which the PH domain naturally binds. Further, the invention provides polypeptides having increased binding specificity for a phosphatidylinositide molecule to which the PH domain ... 06/30/05 - 20050142609 - Native immunoglobulin binding reagents and methods for making and using same Isolated native immunoglobulin binding reagents including antibodies are provided, along with articles of manufacture, compositions and kits that include the native immunoglobulin binding reagents. Labeled reagents and substrates that comprise samples or the reagents are provided. Methods of screening for, making and using the reagents are also provided. ... 06/30/05 - 20050142608 - Screening method and device, and new drug screening method and device The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of ... 06/30/05 - 20050142607 - Tools for detecting moraxella catarrhalis The present invention provides compositions and methods useful for detecting Moraxella catarrhalis. The compositions are antibodies, proteins or nucleic acid sequences specific to Moraxella catarrhalis (M. catarrhalis). The method comprises the steps of obtaining a biological sample from an individual and detecting within the biological sample the presence of proteins, ... 06/30/05 - 20050142606 - Determination of ions using ion-sensitive enzymes The invention relates generally to the field of sodium and lithium ion detection. In particular, the invention provides chimeric proteins, nucleic acids encoding chimeric proteins, methods and kits for assaying for sodium ions and for lithium ions in a sample, using inter alia, a 3′(2′),5′-bisphosphate nucleotidase. ... 06/23/05 - 20050136485 - Iterative one-pot oligosaccharide synthesis A process for synthesizing an oligosaccharide includes (a) activating a protected glycosyl donor with a promoter in the absence of a glycosyl acceptor to produce a reactive intermediate, the glycosyl donor having an activatable aglycon at the anomeric carbon; (b) adding a protected glycosyl donor/acceptor to the reactive intermediate to ... 06/23/05 - 20050136484 - Method for screening agents for the treatment of diabetes A convenient screening tool and a convenient screening method for obtaining an agent for treating diabetes, a pharmaceutical composition for treating diabetes, and a process for manufacturing the pharmaceutical composition are disclosed. The screening tool is a G protein-coupled receptor, a variation functionally equivalent thereto, or a homologous polypeptide thereof ... 06/23/05 - 20050136483 - Nanodevices employing combinatorial artificial receptors The present invention includes nanodevices employing combinatorial artificial receptors and methods for making and using the same. In an embodiment the invention includes a method of adhering components together. In an embodiment, the invention includes a device including a first component adhered to a second component via a binding pair ... 06/23/05 - 20050136482 - In vitro methods for determining in vivo thrombotic events Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed. ... 06/23/05 - 20050136481 - Systems and methods for predicting the structure and function of multipass transmembrane proteins The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the structure of transmembrane proteins such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a combination of coarse grain sampling ... 06/23/05 - 20050136480 - Computer based versatile method for identifying protein coding dna sequences useful as drug targets The present invention relates to a versatile method of identifying protein coding DNA sequences (genes) useful as drug targets in a genome using specially developed software GeneDecipher, said method comprising steps of generating peptide libraries from the known |