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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Nucleic Acid Involving Nucleic AcidInvolving Nucleic Acid patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.06/07/07 - 20070128656 - Direct fluorescent label incorporation via 1st strand cdna synthesis The present invention provides for highly efficient fluorescent label incorporation during 1st strand complimentary DNA (cDNA) synthesis. This is achieved by the use of labeled random primers (including, but not limited to, random hexamers, septamers, octamers, nonamers and decamers) rather than labeled nucleotides. This invention thus bypasses the well known ... 06/07/07 - 20070128655 - Breast, gastric and prostate cancer associated antigens and uses therefor Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in breast, gastric and prostate cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with cancer. The invention ... 06/07/07 - 20070128654 - Universal-tagged oligonucleotide primers and methods of use The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome. ... 06/07/07 - 20070128653 - Human hac3 The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes ... 06/07/07 - 20070128652 - Fluid processing device comprising radial channels The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) ... 06/07/07 - 20070128651 - Promoter sequences and the use thereof The promoter region and various fragments thereof for the yellow fever mosquito (Aedes aegypti) ribonucleotide reductase small subunit (R2) are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences. ... 06/07/07 - 20070128650 - Solid phase rflp-based snp detection The invention is directed to a method for detection of single nucleotide polymorphisms utilizing a solid phase RFLP-based method of detection. The invention further relates to a method of detecting a single nucleotide polymorphism (SNP) comprising providing a sample test DNA molecule containing an SNP site of interest; detectably labeling ... 06/07/07 - 20070128649 - Synthesis of error-minimized nucleic acid molecules A method is provided for synthesis of error-minimized nucleic acid molecules. Oligonucleotides intended to have fragments of a desired, full-length nucleotide sequence, and optionally containing other desired nucleotides, such as nucleotides for binding the oligonucleotides to a substrate, are obtained. Oligonucleotides for both strands of the desired, full-length sequence may ... 06/07/07 - 20070128648 - Methods for the identification of ikkalpha function and other genes useful for treatment of inflammatory diseases The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-κB pathway; determining the level of expression of ... 06/07/07 - 20070128647 - Methods for high throughput genotyping Methods for genotyping polymorphisms using allele specific probes are disclosed. A training set is used to generate a model for each polymorphism to be interrogated. The training set is used to obtain an estimate of the asymmetry between an intensity measurement for a first allele and an intensity measurement for ... 06/07/07 - 20070128646 - Hybridization of pna probes in alcohol solutions This invention features methods, kits and compositions for hybridization of PNA probes in diagnostic applications. This invention is further directed toward the use of said methods, kits and compositions for both fixation of cells and hybridization to nucleic acid targets within fixed cells. ... 06/07/07 - 20070128645 - Use of kiaa0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a ... 06/07/07 - 20070128644 - Fluid control method and fluid control apparatus The object of the present invention is to enable a probe to uniformly encounter biopolymers in a sample solution, regardless of a position in a reaction chamber. In the present invention, a fluid displacement between a reaction chamber and ports communicating therewith in a biochemical reaction part is controlled by ... 06/07/07 - 20070128643 - Method for assaying nucleic acid fragment and kit thereof The present invention is related to a novel method for assaying high quantity of nucleic acid fragments, by using the single-stranded anchor nucleic acid probe with biotin and this single-stranded anchor nucleic acid hereto form double-stranded nucleic acid with the target nucleic acid fragment. To detect the target fragment does ... 06/07/07 - 20070128642 - Method of isolation and self-assembly of small protein particles from blood and other biological materials Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation ... 06/07/07 - 20070128641 - Sirna targeting hypoxia-inducible factor 1 Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. ... 06/07/07 - 20070128640 - Sirna targeting ras-related nuclear protein Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. ... 06/07/07 - 20070128639 - Molecular profiling of cancer The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides cancer markers useful in the diagnosis and characterization of prostate and breast cancers. ... 06/07/07 - 20070128638 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes. ... 06/07/07 - 20070128637 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes. ... 06/07/07 - 20070128636 - Predictors of patient response to treatment with egfr inhibitors The invention concerns genes and gene sets and methods useful in the prediction of the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor. ... 06/07/07 - 20070128635 - Selected amplification of polynucleotides The invention provides methods and compositions for selectively amplifying one or more target polynucleotides in a sample. In one aspect, a plurality of selection oligonucleotides are provided that are capable of simultaneously annealing to separate regions of a target polynucleotide to form a complex that is enzymatically converted into a ... 06/07/07 - 20070128634 - Separation and purification of nucleic acid from paraffin-containing samples Disclosed are rapid and reproducible methods for separating and purifying nucleic acids from paraffin-containing tissue samples. The disclosed methods involve a melting step, where paraffin-containing tissue samples are heated in the presence of a detergent, causing the paraffin to melt and tissue sample cells to lyse. From the resulting two-phase ... 06/07/07 - 20070128633 - Cell-free protein expression systems and methods of use thereof Provided herein are in vitro (cell-free) protein translation (IVT) systems for the expression of kinases. In particular, provided herein is an IVT system for the expression of a panel of protein tyrosine kinases (PTK), (e.g., receptor protein tyrosine kinases (RTK) and/or cytoplasmic tyrosine kinases (CTK)), and/or fragments thereof (e.g., kinase ... 06/07/07 - 20070128632 - Methods for amplification of nucleic acids using spanning primers The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences. ... 06/07/07 - 20070128631 - Gene finding using ordered sets A method and system for finding in a DNA sequence, a gene represented by an ordered set of marker strings. Sub-strings in the DNA sequence matching each marker string are identified. In a set ordered via occurrence of the marker strings in the ordered set of marker strings, the score ... 06/07/07 - 20070128630 - Hpv cd8+ t-cell epitopes The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention ... 06/07/07 - 20070128629 - Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing There is provided a method for directly typing or sequencing HLA-A, -B, or -C alleles from a tissue sample wherein exons 2 and 3 of the HLA-A, -B, or -C alleles from the sample are amplified together in a locus specific manner and then separated out and individually amplified in ... 06/07/07 - 20070128628 - Universal method for selective amplification of mrnas The invention relates generally to methods for the amplification of ribonucleic acids, including for example messenger ribonucleic acids (mRNAs). In an embodiment, the invention also relates to kits for amplifying ribonucleic acids, including for example mRNAs. In another embodiment, the invention relates to kits comprising the components for performing the ... 06/07/07 - 20070128627 - Novel cofactor that modulates steroid receptor activities The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ... 06/07/07 - 20070128626 - Assessing response to anti-cd20 therapy by genotyping c1q components The present invention encompasses methods for predicting metastasis in cancer by assessing the structure of the complement protein C1qA. The methods may encompass examining either protein or nucleic acids, and may further include making treatment decisions based on the predictive methods. ... 06/07/07 - 20070128625 - Drug-resistant mutants of hepatitis c virus The present invention provides nucleotides, peptides, HCV mutants, and cell lines containing mutations associated with drug resistance. In addition, the present invention provides methods for screening for therapeutic compounds capable of inhibiting HCV as well as methods for inhibiting HCV, e.g., by targeting specific binding sites associated with HCV drug ... 06/07/07 - 20070128624 - Method of preparing libraries of template polynucleotides The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5′ ends and at their ... 06/07/07 - 20070128623 - Biomolecule interaction using atomic force microscope The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the ... 06/07/07 - 20070128622 - Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera Our invention relates to a new way of preparing coding DNA constructs, by making a chimera of various coding region isoforms. For example, our method has been successfully used to make a new hGH-NV cDNA chimera having SEQ ID NO: 3, by combining the cDNA isoforms of human placenta and ... 06/07/07 - 20070128621 - Analyzing messenger rna and micro rna in the same reaction mixture The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, ... 06/07/07 - 20070128620 - Hot start reverse transcription by primer design The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target polynucleotide with a hot start primer comprising a blunt-ended self-complementary stem, and a loop, and extension products form at high temperatures but reduce extension product ... 06/07/07 - 20070128619 - Human fgf-21 gene and gene expression products This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-2 1. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, ... 06/07/07 - 20070128618 - Systems and methods for characterization of molecules The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as ... 06/07/07 - 20070128617 - Hybridization-mediated analysis of polymorphisms Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is ... 06/07/07 - 20070128616 - Aggrecanase molecules Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed. ... 06/07/07 - 20070128615 - Methods for determining nucleotide sequence information Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences ... 06/07/07 - 20070128614 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 06/07/07 - 20070128613 - Pcr based capsular typing method The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci. ... 06/07/07 - 20070128612 - Dna family tree kit A DNA family tree kit includes a storage case configured to receive a plurality of DNA storage boxes, a variety of mechanisms for collecting samples of DNA family members and a genealogical organization system that includes a family tree. A method of collecting, storing and categorizing DNA includes collecting at ... 06/07/07 - 20070128611 - Negative control probes In an embodiment, a method is included for generating a negative control probe sequence for an array including selecting biological probe sequences from the array randomly, generating a plurality of candidate probe sequences by randomly permuting the selected biological probe sequence, and screening the candidate probe sequences for sequence similarity ... 06/07/07 - 20070128610 - Sample preparation method and apparatus for nucleic acid sequencing The invention provides methods and apparatus for preparation and sequencing of nucleic acids. ... 06/07/07 - 20070128609 - Ddr2 protein with activated kinase activity and preparation method thereof The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase ... 06/07/07 - 20070128608 - Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor [Problems] To provide a novel mixture for assaying a target nucleic acid, characterized by enabling a nucleic acid assay while: 1) requiring no step of diluting the target nucleic acid; 2) requiring no procedure of changing a probe concentration depending on a concentration of the target nucleic acid. [Means for ... 06/07/07 - 20070128607 - Method for distinguishing aml subtypes with different gene dosages Disclosed is a method for distinguishing AML subtypes with different gene dosages selected from AML-TRI8, AML-TRI11, AML-TRI13, AML-MO7, and/or AML-DEL5q in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers. ... 06/07/07 - 20070128606 - Prkcs as modifiers of the beta catenin pathway and methods of use Human PRKC genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PRKC are provided. ... 06/07/07 - 20070128605 - Triacylglycerol-deficient fission yeast and its uses A fission yeast having non-functional dga1 and plh1 genes, which is incapable of synthesizing triacylglycerols, is disclosed. The fission yeast is susceptible to lipotoxicity including lipoapoptosis, and is useful for screening of compounds that inhibit or prevent lipotoxicity or lipoapoptosis. The fission yeast strain may be transformed to express a ... 06/07/07 - 20070128604 - Variants of human taste receptor genes Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele ... 06/07/07 - 20070128603 - Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7) The invention provides a human 5-HT7 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention ... 06/07/07 - 20070128602 - Polynucleotide associated with a colon cancer comprising single nucleotide poylmorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof. ... 06/07/07 - 20070128601 - Identification and characterization of racemases, definition of protein signatures, and a test for detecting d-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs ... 06/07/07 - 20070128600 - Alpha macroglobulin family member This invention relates to a protein, termed INSP097, herein identified as a member of the alpha macroglobulin family, in particular as an alpha-2-macroglobulin-like proteinase inhibitor, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. ... 06/07/07 - 20070128599 - Method for improved diagnosis of dysplasias The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without ... 06/07/07 - 20070128598 - Methods for generating rna copies The present invention is directed to a novel method of efficiently synthesizing, in a non-specific manner, multiple copies of a target RNA. The present invention also relates to kits relating to the same and the use of these copies for determining gene expression pattern. In particular, the present invention relates ... 06/07/07 - 20070128597 - Single nucleotide polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy Single Nucleotide Polymorphisms sensitively predicting Advserse Drug Reactions (ADR) and Drug Efficacy Abs tract. The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the ... 06/07/07 - 20070128596 - Reagents and methods for identifying and modulating expression of tumor senescence genes This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression ... 06/07/07 - 20070128595 - Novel polynucleotide and polypeptide sequences and uses thereof The present invention provides a purified nucleic acid encoding a putative transmembrane receptor polypeptide comprising at its N-terminus leucine rich repeats and at least an immunoglobulin domain. S30-21616/DEGA polypeptide of the present invention, analogs of said polypeptide, vectors and host cells that embody the polynucleotides, bio-immunopharmaceutical compositions and diagnostic reagents ... 06/07/07 - 20070128594 - Protein c polymorphisms The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined ... 06/07/07 - 20070128593 - Sga-1m, a cancer associated antigen, and uses thereof The present invention relates to a gene and gene product, SGA-1M that is differentially expressed in cancer tissues and cell lines. Suppression Subtractive Hybridization and microarray screening were used to screen for differential expression of SGA-1M in cancer tissues and cell lines. Expression analysis has demonstrated overexpression of SGA-1M in ... 06/07/07 - 20070128592 - Method and nucleic acids for the analysis of a lung cell proliferative disorder The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders, ... 06/07/07 - 20070128591 - Methods for diagnosing and treating diseases and conditions of the digestive system and cancer The invention provides methods of diagnosing diseases and conditions of the digestive system and cancer, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in ... 06/07/07 - 20070128590 - Methods for determining therapeutic resonant frequencies Methods are provided for readily and efficiently determining resonant frequencies that can be used therapeutically or beneficially, for debilitation of specific types of genomic materials, including DNA and/or RNA, genes, and gene sections. The methods can be used in a variety of circumstances related to various human and animal diseases ... 05/31/07 - 20070122839 - Methods and compositions for nucleic acid analysis The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides. ... 05/31/07 - 20070122838 - Methods and computer software products for identifying transcribed regions of a genome Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning ... 05/31/07 - 20070122837 - Mothod for the synthesis of dna sequences A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into smaller overlapping DNA segments. A maskless microarray synthesizer is used to make a DNA microarray on ... 05/31/07 - 20070122836 - Control of tgfbeta signaling by km23 superfamily members Methods of identifying therapeutic agents that inhibit, potentiate or mimic the ability of a km23 polypeptide mutant form, or a nucleic acid encoding the mutant form to modulate the signal transduction activity of a growth factor or cytokine are provided. The methods involve treating a cell with a candidate compound ... 05/31/07 - 20070122835 - Methods for detection of genetic disorders The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present ... 05/31/07 - 20070122834 - Biochip substrate holding method and biochip-reader The present invention is characterized by the following points: In measurement of a biochip whose substrate is held on a base and samples are spotted onto the sites in an array on the substrate, a biochip substrate holding method, which does not generate deviation of site positions between the arrangement ... 05/31/07 - 20070122833 - Enzymatic deposition and alteration of metals Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is ... 05/31/07 - 20070122832 - Process for preparing l-amino acids The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which ... 05/31/07 - 20070122831 - Detection and source identification of microbial contaminants in water samples The present invention relates generally to methods of microbial source tracking in environmental water samples. More specifically the present invention relates to methods of microbial source tracking using detection of Bifidobacterium species as markers of source contamination in environmental water samples. The present invention utilizes differences in DNA sequence between ... 05/31/07 - 20070122830 - Prohibitin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance Disclosed are methods for treating neoplastic cells, including reversing or preventing chemotherapeutic drug resistance, by increasing the sensitivity of the neoplastic cells to a chemotherapeutic drug. In addition, methods are further disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of prohibitin in ... 05/31/07 - 20070122829 - Device and method for measuring analytes The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at ... 05/31/07 - 20070122828 - Short cycle methods for sequencing polynucleotides The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion. ... 05/31/07 - 20070122827 - Target nucleic acid signal detection Provided herein are methods, compositions and kits for detecting a target nucleic acid. A target nucleic acid can be produced, for example, by a cleavage reaction in an assay for detection of biological samples. In one aspect, a described method comprises the following steps: hybridizing the target nucleic acid having ... 05/31/07 - 20070122826 - Minimal bacterial genome The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set ... 05/31/07 - 20070122825 - Method to predict the response to lithium treatment The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment. ... 05/31/07 - 20070122824 - Method and kit for assessing a patient's genetic information, lifestyle and environment conditions, and providing a tailored therapeutic regime A method of determining a personalised therapeutic regime, comprising: receiving genetic information relating to a patient; determining genetic criteria relevant to a personalised therapeutic regime for the patient using the genetic information; receiving personal information relating to the patient; determining personal criteria relevant to the personalised therapeutic regime using the ... 05/31/07 - 20070122823 - Amniotic fluid cell-free fetal dna fragment size pattern for prenatal diagnosis The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include analysis of the fragment size distribution of cell-free fetal DNA isolated from amniotic fluid. The inventive methods allow for rapid screening of fetal characteristics such as chromosomal abnormalities and for prenatal diagnosis ... 05/31/07 - 20070122822 - Compositions and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group. ... 05/31/07 - 20070122821 - Antisense composition and method for treating muscle atrophy A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has ... 05/31/07 - 20070122820 - Balanced translocation in comparative hybridization The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations. ... 05/31/07 - 20070122819 - Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same The object of the present invention is to provide a sample assay structure in a microfluidic chip for quantitative analysis which comprises a sample inlet port for inputting a testing sample; an analyte detection region, coupled to the sample inlet port, consisting of at least one microfluidic channel, in which ... 05/31/07 - 20070122818 - Gene methylation assay controls Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them. ... 05/31/07 - 20070122817 - Methods for assembly of high fidelity synthetic polynucleotides Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or ... 05/31/07 - 20070122816 - Microarray comprising qc probes and method for fabricating the same A quality control (QC) probe for inspecting a quality of a microarray, a method for fabricating a microarray in which the QC probe and a target probe are immobilized on a support, and a method for inspecting the quality of a microarray using the QC probe are provided. More particularly, ... 05/31/07 - 20070122815 - Solid support for nucleic acid detection The present invention relates to solid supports for control nucleic acids. The present invention also relates to methods for the manufacture thereof, and methods of use thereof. ... 05/31/07 - 20070122814 - Methods for distinguishing prognostically definable aml Disclosed is a method for distinguishing prognostically definable AML subtypes with normal karyotype into different prognosis subsets in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers. ... 05/31/07 - 20070122813 - Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the ... 05/31/07 - 20070122812 - Method of screening for protein secretion recombinant host cells The invention describes a method of screening for protein secreting recombinant host cells comprising screening for promoter activity of a stress inducible promoter. The method can be used for rapid identification of actively secreting transformants and can be used to screen recombinant libraries for transformants secreting proteins. ... 05/31/07 - 20070122811 - Compositions and processes for genotyping single nucleotide polymorphisms The invention relates to processes, compositions and kits for analysis of nucleic acid variations, especially single nucleotide polymorphisms (SNPs). An inventive process includes a procedure to enzymatically remove inorganic pyrophosphate from a sample prior to and/or during a single base extension reaction. Processes and compositions described herein are especially useful ... 05/31/07 - 20070122810 - Brain tumor marker and method of diagnosing brain tumor The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein ... 05/31/07 - 20070122809 - Nucleic acid isolation The invention provides materials and methods for purifying nucleic acids from a biological sample held in a container (30) such as a centrifuge tube. A filtration unit (1) having a filter (7, 9) and a filtrate chamber (5) is placed within the container (30). Preferably the exterior of the filtration ... 05/31/07 - 20070122808 - Measurement of a polynuleotide amplification reaction A quantitative measurement of the progress of a polynucleotide amplification reaction can be made by: (i) carrying out a reaction for the amplification of a target polynucleotide; (ii) either during or after the amplification reaction contacting the amplified product with a molecule that binds to or interacts with a polynucleotide, ... 05/31/07 - 20070122807 - Posh polypeptides, complexes and related methods The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as neurological disorders. ... 05/31/07 - 20070122806 - Predicting graft rejection The present invention features prognostic methods useful in assessing patients who have received a transplant and reagents, optionally packaged as kits or organized as arrays, that can be used to carry out those methods. The inventions are based, in part, on our analysis of gene expression in renal allografts and ... 05/31/07 - 20070122805 - Haplotype analysis The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these ... 05/31/07 - 20070122804 - Combined exponential and linear amplification Methods and compositions are provided for sensitive detection and quantitation of nucleic acids. Methods and compositions are further provided for genotyping. Probes of the invention allow target initiated amplification for single stranded, double stranded polynucleotides and pyrophosphate (PPi). DNA enzyme mediated detection method is also provided for detecting single stranded ... 05/31/07 - 20070122803 - Methods for the detection of polymorphisms in the human oatpf gene The invention provides a method for the detection of a polymorphism in OATPF in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of ... 05/31/07 - 20070122802 - Methods of diagnosing and treating diabetes and insulin resistance The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels ... 05/24/07 - 20070117146 - Allelic variants of gpr50 The present invention provides isolated polynucleotides encoding a receptor gene called GPR50 having at least one polymorphic sites. It furthermore provides a method for analyzing polymorphic sites in the receptor gene. Certain of these polynucleotides having a polymorphic site (allelic variants) are found to be more prevelant in a population ... 05/24/07 - 20070117145 - Interferon-alpha induced genes The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-α administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression ... 05/24/07 - 20070117144 - Oligonucleotides useful for detecting and analyzing nucleic acids of interest The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a ... 05/24/07 - 20070117143 - Atm related kinase atx, nucleic acids encoding same and methods of use The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as ... 05/24/07 - 20070117142 - Regulation of novel human asparagine-hydroxylases Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders. ... 05/24/07 - 20070117141 - Identification and cloning of a full-length human clnk-related gene, mist (mast cell immunoreceptor signal transducer) The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or ... 05/24/07 - 20070117140 - Method for selecting antimicrobial agent and utilization thereof The present invention provides for a method for selecting an antimicrobial agent, which comprises a microbe analyzing step in which microbes in the microbial biota of a sample are analyzed based on base sequence of DNA and an antimicrobial agent selecting step comprising performing search in a data base storing ... 05/24/07 - 20070117139 - Method of manufacturing probe carrier A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of ... 05/24/07 - 20070117138 - Splice variant cannabinoid receptor (cb1b) The invention is based on the identification of a novel splice variant of human cannabinoid 1 (CB1) receptor, termed CB1b, and its use in the identification of therapeutic agents and in the diagnosis, prevention and treatment of CB associated disorders such as obesity, psychiatric, pain and neurological disorders. ... 05/24/07 - 20070117137 - Method for the determination of a nucleic acid using a control The present invention is directed to a method for the determination of a target nucleic acid using a special control nucleic acid, a method for the amplification of a partial sequence of said target nucleic acid using primers, a special control and a kit containing said control. The sequence of ... 05/24/07 - 20070117136 - Detection of microsatellite instability and its use in diagnosis of tumors Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to ... 05/24/07 - 20070117135 - Method of inoculation for evaluating candidate therapies for prevention of acquisition of infectious diseases A method of inoculating the vestibular region of the nares with virus, bacteria, fungus, or mold to ascertain whether acquisition and/or prevention of transmission of infection may occur. ... 05/24/07 - 20070117134 - Method for detection and quantification of t-cell receptor vbeta repertoire The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the ... 05/24/07 - 20070117133 - Sparc and methods of use thereof The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of ... 05/24/07 - 20070117132 - System and method for analyzing dependence between gene expressions An amplification-like, unidirectional dependence between expression levels in gene pairs is identified through statistical analysis including a determination of whether there is a specified level of independence (or non-correlation) between X and Z, where X is a random variable representing the expression level of a first gene, Y is a ... 05/24/07 - 20070117131 - Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process Novel processes for the replication of influenza viruses in cell culture, and vaccines and diagnostic compositions which contain the influenza viruses obtainable by the process or constituents thereof, are described. ... 05/24/07 - 20070117130 - Novel activin receptor and uses thereof The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also ... 05/24/07 - 20070117129 - Antigen arrays for treatment of bone disease The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a ... 05/24/07 - 20070117128 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of ... 05/24/07 - 20070117127 - Cross-species nucleic acid probes The present invention features a collection of at least four nucleic acid probes. The probes each comprises a segment, the entirety of which hybridizes under low stringency conditions to at least a first gene of a first species and a second gene of a second species, wherein the hybridizing probes ... 05/24/07 - 20070117126 - Shotgun scanning A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics. ... 05/24/07 - 20070117125 - Method of detecting specific fragments of dna or rna with the aid of a real-time polymerase chain reaction Methods of amplifying specific fragments of DNA or RNA with the aid of a polymerase chain reaction in real time are disclosed. The methods include providing a first oligonucleotide primer that comprises a donor fluorescent dye and a second oligonucleotide primer that comprises an acceptor fluorescent dye; allowing the primers ... 05/24/07 - 20070117124 - Achaete-scute like-2 polypeptides and encoding nucleic acids and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... 05/24/07 - 20070117123 - Salivary protein and rna for breast cancer detection The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva. ... 05/24/07 - 20070117122 - Methods of diagnosing or prognosticating age-related macular degeneration A method for diagnosing or prognosticating age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said ... 05/24/07 - 20070117121 - Cdna library preparation New biochemical protocols for high throughput processing of mRNA samples into cDNA libraries with adaptor sequences compatible with automated sequencing systems are provided. The provided methods produces cDNA libraries which do not have 3′ bias associated with current cDNA library production methods. New methods for the production of DNA libraries ... 05/24/07 - 20070117120 - Mycoplasma detection method and composition A method of detecting the presence of mycoplasma in a sample and a mycoplasm detection kit. A sample is contacted with a first and a second oligonucleotide probe, wherein the first and second oligonucleotide probes are substantially complementary to portions of a 16S ribosomal subunit of at least one mycoplasma ... 05/24/07 - 20070117119 - Carriers having biological substance The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same. ... 05/24/07 - 20070117118 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117117 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117116 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117115 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117114 - Compositions and methods for increasing amplification efficiency Compositions and methods are provided that improve the specificity and efficiency of nucleic acid amplification. A binding partner may be bound to a DNA polymerase enzyme where the binding partner substantially inhibits the activity of the polymerase. A second enzyme modifies the binding partner in a manner that relieves the ... 05/24/07 - 20070117113 - Nucleic acid fragment encoding an nrps for the biosynthesis of anthramycin Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in ... 05/24/07 - 20070117112 - Materials and methods for the generation of fully 2'-modified nucleic acid transcripts Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence. ... 05/24/07 - 20070117111 - Microfabricated reactor, process for manufacturing the reactor, and method of amplification An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of ... 05/24/07 - 20070117110 - Flow cytometric detection method for dna samples Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR ... 05/24/07 - 20070117109 - Nanostructures, methods of making and using the same The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined structure. ... 05/24/07 - 20070117108 - Detection system for pcr assay The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridise to one another in free solution to form a fluorescent quenched pair, that upon introduction of a complementary sequence to one or both sequences ... 05/24/07 - 20070117107 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of ... 05/24/07 - 20070117106 - Identification and/or quantification method of nucleotide sequence (s) elements specific of genetically modified plants on arrays The present invention is related to an identification and/or quantification method of several organisms among many other ones possibly present in the analyzed sample having homologous sequence(s) by the determination of the genetic map of the organism. The method combines a limited number of amplifications of target sequence(s) using common ... 05/24/07 - 20070117105 - Interferon assay The present invention relates to methods and reporter cell assays for determining the ability of a patient sample to induce interferon target gene expression in interferon responsive cells. These methods will be useful for detecting, diagnosing, and monitoring those who have or are at risk of various autoimmune disorders or ... 05/24/07 - 20070117104 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117103 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117102 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117101 - Cleavable oligonucleotide arrays Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described. ... 05/24/07 - 20070117100 - Biomarker for determining predisposition and/or prognosis of hepatocellular carcinoma Disclosed herein are a method for determining predisposition to hepatocellular carcinoma (HCC) in a subject having or suspected to have a hepatic nodule, in particular one infected with at least one of hepatitis B virus and hepatitis C virus, and a method for prognostic evaluation of a subject having or ... 05/24/07 - 20070117099 - Process and apparatus for combinatorial synthesis Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for ... 05/24/07 - 20070117098 - 'signalin' family of tgfbeta signal transduction proteins and uses related thereto The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in a signal transduction induced by members of the TGFβ superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or ... 05/24/07 - 20070117097 - Novel proteins and novel genes encoding the same Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides are disclosed. The novel proteins are activated human macrophage-specific proteins. ... 05/24/07 - 20070117096 - Oscillating temperature capillary electrophoresis and uses therefor Methods for separating biomolecules using oscillating temperature electrophoresis are disclosed. Uses for such methods are also disclosed including high throughput screening, estimation of allele frequencies, identification of polymorphisms, and separation of DNA molecules. ... 05/24/07 - 20070117095 - Diagnostic method for neonatal or infantile epilepsy syndromes A method for the diagnosis of a neonatal or infantile epilepsy syndrome as BFNIS in a patient comprising testing for the presence of an alteration in the SCN2A gene, including in a regulatory region of the gene, in a patient sample, and establishing a diagnosis which will indicate a high ... 05/24/07 - 20070117094 - Support, printed material and reagent kit having enzyme fixed thereon, method for preparing the support, method of storing enzyme and method for restoration enzymes The invention enables enzymes to be stored in a simple manner. Disclosed are a support having an enzyme and a protecting agent for the enzyme fixed thereon; a printed material and a reagent kit comprising the support; a method for preparing the support; a method for restoring the enzyme fixed ... 05/24/07 - 20070117093 - Heavymethyl assay for the methylation analysis of the gstpi gene Described herein is a method for the detection of cyto-sine methylation in DNA samples, wherein the following steps are conducted: a genomic DNA sample, which comprises the DNA to be investigated as well as background DNA is treated with bisulfite (= disulfite, hydrogen sulfite) in such a way that all ... 05/24/07 - 20070117092 - Dna analysis system A DNA analysis system 10 includes a thermal cycler 12 operable as an extraction stage for extracting DNA from a sample to be tested and an as amplification stage for replicating identically a region of interest in DNA strands extracted from the sample. A predetermined proteinase is used in the ... 05/24/07 - 20070117091 - Anti-candida agents for the treatment of prion diseases The invention provides methods of treatment of prion disease, cancers and other conditions, the methods comprising administration of an anti-Candida agent. Also disclosed are methods of diagnosing prion disease and cancers, said methods based on the determination of the presence of Candida infection, in particular systemic candidiasis. ... 05/24/07 - 20070117090 - Processing nucleic acid The present invention relates to a method of processing nucleic acid. More particularly, it relates to a method of purifying extra-chromosomal DNA by removing cell debris and/or RNA from a process stream comprising extra chromosomal DNA and a precipitate resulting from preceding cell lysis and/or precipitation reactions. It also relates ... 05/17/07 - 20070111250 - Probe carrier, method of producing the probe carrier, method of evaluating the probe carrier and method of detecting a target nucleic acid using the same To provide probe carrier having a structure that a single-stranded DNA probe can be immobilized to a carrier effectively and forms of probe dots or spots immobilized to the carrier can be observed accurately by a scanning probe microscope or its derivative technology. A gold-containing film is formed in an ... 05/17/07 - 20070111249 - Automatic threshold setting for quantitative polymerase chain reaction Disclosed are systems and methods for identifying and quantitating the presence of one or more DNA species in a sample population through PCR amplification. DNA species quantitation includes a determination of a threshold fluorescence value used in the assessment of the PCR amplification reaction. Various embodiments of the present invention ... 05/17/07 - 20070111248 - Nucleotide sequences specific to francisella tularensis and methods for the detection of francisella tularensis Described herein is the identification of nucleotide sequences specific to Francisella tularensis that serves as a marker or signature for identification of this bacterium. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of ... 05/17/07 - 20070111247 - Systems and methods for the biometric analysis of index founder populations Systems, methods and apparatus for associating a clinical parameter with one or more candidate chromosomal regions in the human genome are provided. An index founder population is identified in a test population based upon the genotype X of each member of the test population such that the posterior probability Pr(K|X) ... 05/17/07 - 20070111246 - Parametric calibration method Method of preparing a calibration curve and determining the amount of an analyte polynucleotide present in a test sample, particularly using real-time amplification data. The method involves determining indicia of amplification for both the internal calibrator and analyte polynucleotide standards, each as a function of the amount of analyte polynucleotide ... 05/17/07 - 20070111245 - Predicting diabetic nephropathy The invention relates to methods and compositions for identifying subjects who are predisposed to having diabetic nephropathy (DN). ... 05/17/07 - 20070111244 - Tissue diagnostics for breast cancer Disclosed are methods for diagnosing breast cancer in a cell sample by detecting an increase in the levels of expression of protein markers in the cell sample as compared to the levels of expression of the same protein markers in a normal, nonneoplastic breast cell sample. Also disclosed is a ... 05/17/07 - 20070111243 - Detection of polyketide synthetase gene expression in karenia brevis The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the present invention ... 05/17/07 - 20070111242 - Method for producing novel dna sequences with biological activity A method of obtaining an oligonucleotide capable of carrying out a predetermined biological function. A heterogeneous pool of oligonucleotides, x+y+z nucleotides in length, is first generated. Each oligonucleotide has a 5′ randomized sequence, x nucleotides in length, a central preselected sequence, y nucleotides in length, and a 3′ randomized sequence, ... 05/17/07 - 20070111241 - System and method for accessing, tracking, and editing sequence analysis and software to accomplish the same The present invention relates to a system and method for accessing, tracking and editing sequence analysis and software to accomplish the same. The present invention includes embodiments that permit a party, for example a customer, to track the status of the samples (e.g., tissue, blood, or DNA) that the party ... 05/17/07 - 20070111240 - Cysteine variants of interleukin-11 and methods of use thereof Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications. ... 05/17/07 - 20070111239 - Methods of using il-21 An allelic variation in the IL-21 receptor can result in reduced IFN-γ production in individuals and can require administration of different doses of IL-21 to achieve therapeutic effects seen individuals that do not have the allelic variant. Based on the genotype of a patient's IL-21 receptor allele, methods of predicting ... 05/17/07 - 20070111238 - Methods for diagnosing and evaluating treatment of blood disorders Methods, systems and kits are provided for the clinical staging of blood disorders including myelodysplastic syndrome, myeloproliferative diseases and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or progenitor cell subsets. Additional functional, genetic, gene expression, proteomic or other molecular analyses of ... 05/17/07 - 20070111237 - Process for identifying antigenized antibodies using ribosome cell free expression system A process comprising (1) contacting a single-chain variable region (ScVr) mRNA library with a cell free ribosome expression system to produce a library of complexes each comprising a ribosome, an ScVr mRNA and a nascent single chain antigenized antibody encoded by the ScVr mRNA (ARM complexes) wherein the ScFv mRNA ... 05/17/07 - 20070111236 - Streptococcus suis vaccines and diagnostic tests The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derived thereof. The invention further provides ... 05/17/07 - 20070111235 - Detecting dna sequence variations A method of analysing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analysed. ... 05/17/07 - 20070111234 - Detection of biological dna The present invention provides a method, a kit and a system for the analysis of samples with respect to the presence of biological DNA based on real-time polymerase chain reaction (PCR) in combination with an analyzing step. The method comprises the steps of performing a universal real-time PCR to amplify ... 05/17/07 - 20070111233 - Prenatal diagnosis using cell-free fetal dna in amniotic fluid The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal ... 05/17/07 - 20070111232 - Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/17/07 - 20070111231 - Detection of mutations in a gene associated with resistance to viral infection, oas2 and oas3 Compositions and methods are provided for detecting a mutation in a human oligoadenylate synthetase gene, particularly OAS2 or OAS3, wherein the mutation confers resistance to flavivirus infection, including infection by hepatitis C virus, and the mutation relates to other disease states including prostate cancer and diabetes, and uses of the ... 05/17/07 - 20070111230 - Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/17/07 - 20070111229 - Pathogenicity determinants which can be used as targets for developing means for preventing and controlling bacterial infections and/or systemic dissemination The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising: using a strain of the pathogenic microorganism, generating mutants for inactivation in the genes encoding these factors, determining the virulence of these mutants on an expiremental model ... 05/17/07 - 20070111228 - Rna interference The present invention relates to RNA interference and methods for selecting interfering RNAs. The present invention also relates to modified interfering RNAs. The present invention also relates to methods of reducing the level of a specific mRNA in a cell, methods for reducing the level of a specific protein in ... 05/17/07 - 20070111227 - Small regulatory rnas and methods of use The present invention relates to unique small ribonucleic acid molecules, for example siRNAs and miRNAs, identified and isolated using MPSS. Specifically, the invention is directed to the identification of a library of unique small RNA sequences from Arabidopsis thaliana. In another aspect, the small RNA sequences themselves are useful for ... 05/17/07 - 20070111226 - Method to quantify sirnas, mirnas and polymorphic mirnas The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA ... 05/17/07 - 20070111225 - System and method for monitoring an analyte The present invention provides for a monitoring system and method to monitor an analyte, including determining the presence of the analyte and analyzing the analyte; for example, cellular chorography and biological threats. The system and method use a fluidics apparatus (e.g., a flow cytometer), a computer, a probe synthesizer and/or ... 05/17/07 - 20070111224 - Electrochemical sensor for detecting biomolecule, metthod of manufacturing the same, and method of detecting biomolecule using the same Provided is a sensor for detecting a biomolecule, which includes: a substrate; a first material, immobilized on the substrate, having a cavity structure; a secondary material capable of selectively binding to the cavity structure of the first material and having electrochemical activity; and a probe biomolecule immobilized to the secondary ... 05/17/07 - 20070111223 - Method for detecting disease-associated mutations A method is described for diagnosing individuals as having hypertrophic cardiomyopathy, e.g. familial or sporadic hypertrophic cardiomyopathy. The method provides a useful diagnostic tool which becomes particularly important when testing asymptomatic individuals suspected of having the disease. Symptomatic individuals have a much better chance of being diagnosed properly by a ... 05/17/07 - 20070111222 - Nucleic acid aptamer-based compositions and methods The present invention relates to compositions that can detect the presence of specific entities or substances in an environment, and provide an amplified response to the detection as manifested by release of enzymes, reporter signals or drugs. The detection and response is based on nucleic acid functionalities, such as aptamer ... 05/17/07 - 20070111221 - Method of preparation for pharmaceutical grade plasmid dna This invention provides a process for the continuous alkaline lysis of a bacterial suspension in order to harvest pDNA. It further provides for optional additional purification steps, including lysate filtration, anion exchange chromatography, triplex affinity chromatography, and hydrophobic interaction chromatography. These optional purification steps can be combined with the continuous ... 05/17/07 - 20070111220 - Sensing phage-triggered ion cascade (septic) The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within ... 05/17/07 - 20070111219 - Label integrity verification of chemical array data Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a sample assayed by chemical array analysis. A sample is divided into equal aliquots. At least first and second labels are incorporated into biopolymers contained in first and second aliquots of the equal aliquots, respectively. The ... 05/17/07 - 20070111218 - Label integrity verification of chemical array data Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a single sample assayed by chemical array analysis. At least first and second labels are incorporated into biopolymers in the single sample to produce a multi-labeled, single sample. The multi-labeled, single sample is hybridized with probes ... 05/17/07 - 20070111217 - Quantitative trait locus prognostic for changes in regional adiposity and bmi in caucasian males Caucasian males, but not females, presenting with statistically significant increases of L162V allelic SNP of the PPARα gene, relative to that of wild-type homozygotes, have an increased likelihood of increased regional adiposity (subcutaneous fat) and BMI, and are more likely to develop diseases associated with such changes, such as type ... 05/17/07 - 20070111216 - Methods for identifying polymerase inhibitors The present invention relates to methods and compositions for the identification of enzyme inhibitors. In particular, the present invention relates to the identification of nucleic acid polymerase inhibitors. ... 05/17/07 - 20070111215 - Customized oligonucleotide microchips that convert multiple genetic information to simpler patterns, are portable and reusable This invention relates to using customize oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals ... 05/17/07 - 20070111214 - 20685, 579,17114, 23821, 33894 and 32613, novel human transporters The present invention relates to newly identified human transporters. In particular, the invention relates to transporter polypeptides and polynucleotides, methods of detecting the transporter polypeptides and polynucleotides, and methods of diagnosing and treating transporter-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel ... 05/17/07 - 20070111213 - Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles The present invention describes primers, methods and kits for amplifying and identifying HLA alleles. Using these primers, all HLA alleles at a single locus can be amplified using either a multiplex or non-multiplex PCR approach. Within sets of the primers, control primer pairs may be used to produce control amplicons ... 05/17/07 - 20070111212 - Method of detecting nucleic acid and utilization thereof It is intended to provide a method of detecting a nucleic acid whereby a target nucleic acid can be accurately and quickly detected at an elevated detection sensitivity compared with the existing methods; and a gene detection kit with the use of this method. A sample containing cells is fixed ... 05/17/07 - 20070111211 - Integrated viral complexes, methods of production thereof, vaccines containing same and methods of use thereof Integrated viral complexes, methods of producing them, and their use as a vaccine against is described. Integrated viral complexes are optionally dried and may be stored at refrigeration temperatures. Integrated viral complexes include viable virions in intact cell membranes. The host cells are non-viable. The invention is advantageously employed in ... 05/17/07 - 20070111210 - Biomarkers for graft rejection Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed ... 05/17/07 - 20070111209 - Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders An association between psychiatric disorders and disorders comorbid with psychiatric disorders, and genetic markers in the 8p23 genomic region is described. Markers are also provided to diagnose or detect a susceptibility to disorders comorbid with panic disorder and independently of comorbidity with panic disorder. Methods and surrogate markers for detecting ... 05/17/07 - 20070111208 - Determination of free fractions The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmaco-logically active compounds in aqueous solutions and serum. The invention also relates to ... 05/17/07 - 20070111207 - Partially double stranded nucleic acid molecules A nucleic acid molecule for detecting a nucleic acid molecule is provided which is a partially double-stranded nucleic acid molecule consisting of (a) a single-stranded nucleic acid molecule complementary to the nucleic acid molecule to be detected and (b) one or two single-stranded nucleic acid molecules that hybridize with part ... 05/17/07 - 20070111206 - Method for diagnosis of tuberculosis by smear microscopy, culture and polymerase chain reaction using processed clinical samples and kit thereof The present invention relates to a method of processing clinical samples for diagnosing bacterial infections by smear microscopy, culture or PCR as well as a kit for performing the said method. This invention also pertains to two sets of primers specific for the DevR gene of M. tuberculosis as well ... 05/17/07 - 20070111205 - Detection of somatic cells in milk A simple, rapid and accurate method for detecting nucleic acids from milk are disclosed. The methods are useful in determining somatic cell count levels and diagnosing mastitis in cows. ... 05/17/07 - 20070111204 - Methods for detecting nucleic acid variations The invention provides methods and diagnostic test kits for detecting target nucleic acid sequence variations in a sample. In particular, a plurality of oligonucleotide probe sets is provided. Each set has a target specific portion and a barcode. The target specific portions of the probes are suitable for ligation together ... 05/17/07 - 20070111203 - Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. ... 05/10/07 - 20070105148 - Sphingosine 1-phosphate receptor gene, sppr A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases. ... 05/10/07 - 20070105147 - Rapid method for screening compounds for in vivo activity The present invention provides a rapid method for screening potentially pharmaceutically useful compounds for activity in vivo. The method has the steps of growing a target cell into which a reporter gene was introduced in a biocompatible, semipermeable encapsulation device; implanting the semi-permeable encapsulation device into a subject; administering a ... 05/10/07 - 20070105146 - Detection of susceptibility to autoimmune diseases The present invention provides methods and reagents for determining sequence variants present at the IL4 receptor, IL-4 and IL-13 loci, which facilitate identifying individuals at risk for type 1 diabetes. ... 05/10/07 - 20070105145 - Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... 05/10/07 - 20070105144 - Method of nucleic acid analysis It is intended to provide a method of efficient, high-precision quantitative analysis of a gene region with plural possible sequences by simultaneously separating and detecting standard and measurement nucleic acids overlapping in their detection times. The present invention provides a method of quantitative analysis of a gene region with plural ... 05/10/07 - 20070105143 - Novel bhlh type transcription factor genes Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily. ... 05/10/07 - 20070105142 - Methods for prognosis and monitoring cancer therapy The present invention also relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of HER-2, EGFR, VEGF, u-PA, p-PAI-1, and soluble forms thereof, ... 05/10/07 - 20070105141 - Use of azetidinone compounds The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents ... 05/10/07 - 20070105140 - In vivo production of cyclic peptides The present invention relates to methods and compositions utilizing inteins to generated libraries of cyclic peptides in vivo. ... 05/10/07 - 20070105139 - Fluorescent probe and fluorescence detecting method A fluorescent probe having a base sequence complementary to a specific sequence in a target nucleic acid, wherein the fluorescent probe has one end labeled with a nano particle fluorescent material, and the other end labeled with a fluorescent dye capable of fluorescence resonance energy transfer from the nano particle ... 05/10/07 - 20070105138 - Method for detection of a target nucleic acid with a fen nuclease The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of ... 05/10/07 - 20070105137 - Biomarkers for toxic algae The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can ... 05/10/07 - 20070105136 - Methods for identifying, diagnosing, and predicting survival of lymphomas Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis ... 05/10/07 - 20070105135 - Charged compounds comprising a nucleic acid binding moiety and uses therefor Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing ... 05/10/07 - 20070105134 - Efficacy of calcimimetic agents A method of assessing the efficacy of a calcimimetic drug to treat hyperparathyroidism in a subject may include determining which alleles for a calcium-sensitive receptor (CaSR) gene the subject carries; and concluding that the calcimimetic drug will have a first or highest efficacy if the subject has a 990Gly-990Gly genotype, ... 05/10/07 - 20070105133 - Compositions and methods for treating and diagnosing cancer The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor ... 05/10/07 - 20070105132 - Nucleic acid sequencing by raman monitoring of uptake of nucleotides during molecular replication The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake ... 05/10/07 - 20070105131 - Sequencing of surface immobilized polymers utilizing microfluorescence detection Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid ... 05/10/07 - 20070105130 - Compositions and methods for the treatment of cancer Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer. ... 05/10/07 - 20070105129 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection ... 05/10/07 - 20070105128 - Detection of genetic polymorphisms The present invention relates to genetic polymorphism data, compositions and methods for detecting genetic polymorphisms, methods for evaluating drugs using genetic polymorphisms and screening methods for drugs. ... 05/10/07 - 20070105127 - Method for producing modified glycoproteins Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower ... 05/10/07 - 20070105126 - Device for monitoring polymerase chain reactions A method for calibrating temperature can include cycling temperatures of a set of wells, wherein each well of the set comprises a sample with a spectrally distinguishable species. The method can further include measuring a signal from the spectrally distinguishable species for each well at a temperature during a first ... 05/10/07 - 20070105125 - Chemical array housing having a gas delivery element and methods of using the same Chemical array housings configured for use with chemical array readers are provided, where the housings include at least one chemical array holding element and a gas delivery element. Aspects of the invention include positioning a chemical array in the housing and introducing a gas into the housing. Also provided are ... 05/10/07 - 20070105124 - Methods and kits for nucleic acid amplification Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 05/10/07 - 20070105123 - Ire-1alpha substrates IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity. ... 05/10/07 - 20070105122 - Primers for synthesizing full-length cdna and their use Primers for synthesizing full-length cDNAs and their use are provided. 5602 cDNA encoding a human protein has been isolated and nucleotide sequences of 5′-, and 3′-ends of the cDNA have been determined. Furthermore, primers for synthesizing the full-length cDNA have been provided to clarify the function of the protein encoded ... 05/10/07 - 20070105121 - Method for the detection of schizophrenia related gene transcripts in blood The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation ... 05/10/07 - 20070105120 - Method of identifying/designing and/or modifying chemical species capable of interacting with a physiologically active macromolecule The present invention relates to a method of identifying/designing and/or modifying species capable of interacting with a protein molecule that is a potential drug target. ... 05/10/07 - 20070105119 - Method for detecting analytes by means of an analyte/polymeric activator bilayer arrangement The invention relates to the field of analytical sensors. In particular, the invention relates to a method for the detection of analytes in a sample by means of an electrode arrangement, which is characterized by the formation of a conductive bilayer of analytes and an agent for increasing the conductivity ... 05/10/07 - 20070105118 - Method for distinguishing aml subtypes with recurring genetic aberrations Disclosed is a method for distinguishing AML subtypes with recurring genetic aberrations t(8;21), t(15;17), t(11q23)/MLL, inv(3)/t(3;3), inv(l6), AML_komplext, trisomy 8 sole, trisomy 11 sole, trisomy 13 sole, monosomy 7 sole, del(5q) and/or del(9q) in a sample by determining the expression level of markers, as well as a diagnostic kit and ... 05/10/07 - 20070105117 - Method for in vitro evolution of polypeptides The invention relates to a method for the production and allocation of nucleic acids and polypeptides coded thereby. Said method can be used for evolutionary selection of polypeptides in vitro. The inventive method makes it possible to allocate nucleic acids to the polypeptides coded thereby and to select and isolate ... 05/10/07 - 20070105116 - Metal complex type nucleic acid An object of the present invention is to provide a novel structure that enables one-dimensional arraying of metal atoms and can stably exist. The present invention relates to a double-stranded oligonucleotide derivative, which contains two oligonucleotide derivatives each containing at least one nucleotide derivative wherein a base portion of a ... 05/10/07 - 20070105115 - Promoter of the human fatp5 gene and uses The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates ... 05/10/07 - 20070105114 - Biomarkers of cyclin-dependent kinase modulation Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates ... 05/10/07 - 20070105113 - Methods of degrading dsrna and synthesizing rna A protein having an activity of degrading a dsRNA, namely, being capable of acting on a long-chain dsRNA to form a dsRNA of a definite length; a method of efficiently preparing a dsRNA of a definite length which comprises treating a dsRNA with the protein having an activity of degrading ... 05/10/07 - 20070105112 - Laccases, nucleic acids encoding them and methods for making and using them The invention provides laccases, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention relates to the enzymatic production of nootkatone by way of the conversion of valencene using proteins having a laccase activity, e.g., a novel laccase of the invention. In one aspect, ... 05/10/07 - 20070105111 - Method for structuring a substrate surface In a method for structuring the surface of a substrate, a substrate is elastically expanded by the application of a tensile stress so that a surface area of the substrate in which a structure is to be created, is enlarged. Then, in the surface area, a structure is produced that ... 05/10/07 - 20070105110 - Mutation associated with strokes The present invention relates to a method of identifying a subject predisposed to ischemic stroke. The method includes the step of identifying a mutation in the subject that reduces the release rate of tissue plasminogen activator. ... 05/10/07 - 20070105109 - Sirt1 and genetic disorders Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity. ... 05/10/07 - 20070105108 - Polynucleotides capable of target-depedent circularization and topological linkage The invention provides allosterically regulatable polynucleotides capable of target-dependent circularization and topological linkage to a target nucleic acid molecule. Polynucleotides of the invention include a target binding sequence and a regulatory element which prevents circularization in the absence of the target binding. Polynucleotides may include a catalytic domain, allowing circularization ... 05/10/07 - 20070105107 - Marker assisted best linear unbiased prediction (ma-blup): software adaptions for large breeding populations in farm animal species The invention provides methodologies for improved molecular genetic analysis of individual animals and animal populations. The invention includes methods and systems for identifying those animals in a population that are most likely to heritably pass on desirable traits. Provided are means for evaluating the estimated breeding values and increasing the ... 05/10/07 - 20070105106 - Methods and reagents for quantitative analysis of dehalococcoides species The invention sets forth specific probes and primer pairs for such quantitative analysis and methods of obtaining template DNA from the Dehalococcoides species of interest. These techniques are useful in a bioremediation process to monitor and control the dechlorination of chlorinated hydrocarbons. ... 05/10/07 - 20070105105 - Surrogate cell gene expression signatures for evaluating the physical state of a subject The present invention relates to non-invasive and minimally invasive techniques for evaluating the physical state of a subject, including diagnosing a disease, disorder, or physical state of the subject, determining the prognosis of the subject, determining a subject's susceptibility for a disease, disorder, or physical state and determining, developing and ... 05/10/07 - 20070105104 - Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4) The invention provides a human LTB4 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of ... 05/10/07 - 20070105103 - Array having substances fixed on support arranged with chromosomal order or sequence position information added thereto, process for producing the same, analytical system using the array and use of these In fabricating various types of arrays such as a micro array, different kinds of biosubstances, or synthetic substances interacting with the biosubstances, are arranged and immobilized on a support such that the chromosomal order of base sequence blocks, corresponding to the biosubstances, is ascertainable. The biosubstances may be nucleic acids ... 05/10/07 - 20070105102 - Method for detection and characterization of pre-malignant transformation Methods are provided for estimating the risk of developing melanoma and related malignancies in an individual. Methods and compositions for diagnosing, treating, and preventing melanoma and related malignancies also are provided. ... 05/10/07 - 20070105101 - Gene expression associated with osteobla st differentiation The present invention identifies genes whose expression pattern is altered when pre-osteoblastic cells undergo differentiation into mature osteoblasts. The genes identified may be used as markers for the differentiation process. The present invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention ... 05/10/07 - 20070105100 - Process for assay of nucleic acids by competitive hybridization using a dna microarray A process for rapid and simple assay of nucleic acid on the basis of competitive hybridization using a DNA microarray that comprises a step of hybridizing a labeled nucleic acid other than the target nucleic acid with one of the immobilized probes on the substrate, where the labeled nucleic acid ... 05/10/07 - 20070105099 - Nucleic acid amplification using non-standard bases The present invention provides methods, kits and compositions for high fidelity nucleic acid amplification reactions of target nucleic acids such that specific amplification products that incorporate non-standard bases are produced. The amplification reactions can either be linear or exponential. In some embodiments, the fidelity of the amplification reaction is high ... 05/10/07 - 20070105098 - Isolation and use of ryanodine receptors The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial ... 05/10/07 - 20070105097 - Method for comparing gene expression level The present invention relates to a method for comparing and determining the gene expression level, which is very important in disease-related gene screening, early clinical diagnosis and medicine development. The present invention utilizes quantitative characteristics of bioluminescence analysis to compare gene expression levels of different individuals or samples in order ... 05/10/07 - 20070105096 - Endocrine cell lines and methods of using same In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or ... 05/10/07 - 20070105095 - Process for detecting predisposition to a cardiovascular disease Includes the identification in the genetic material of an isolated biological sample from said human an allelic variant which consist on the substitution of a cytosine by an tymine in the position 46 over the transcriptional origin of Factor XII (46C/T) within the locus of chromosome 5, limited by the ... 05/03/07 - 20070099230 - Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecles, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the ... 05/03/07 - 20070099229 - Marburg i mutant of factor vii activating protease (fsap) as risk factor for arterial thrombosis and methods of detecting fsap and fsap mutations A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described. ... 05/03/07 - 20070099228 - Concatameric ligation products: compositions, methods and kits for same The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form ... 05/03/07 - 20070099227 - Significance analysis using data smoothing with shaped response functions Methods, systems and computer readable media for analyzing data. A variable width window is applied to data points from the data which are ordered to correspond to locations along a chromosome of targeted nucleotide sequences whose relative abundances are represented by the data points. The window applied is a moving ... 05/03/07 - 20070099226 - Modified cyclic nucleotide gated ion channels The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments, regulation by Ca2+-calmodulin has been removed in the modified CNG channels. Convenient optical methods for detecting ... 05/03/07 - 20070099225 - Separation of chromosomes using an affinity-based magnetic bead separation in suspension A method for separating and isolating a target chromosome from a cellular sample by using a DNA probe with a fluorescein tag. Magnetic beads bound to anti-fluorescein isothiocyanate antibody were reacted with the fluorescently labeled pool of chromosomes and then separated in suspension by exposure to a magnetic field. ... 05/03/07 - 20070099224 - Slc1a1 marker for anxiety disorder The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A ... 05/03/07 - 20070099223 - Single nucleotide polymorphism associated with stroke susceptibility The present invention identifies various risk alleles, particularly a risk allele of SNP rs918592, within the PDE4D gene as novel stroke associated risk markers. These markers may be used for identifying a subject's susceptibility to stroke and diagnosing a subject's susceptibility to a particular type of stroke based on the ... 05/03/07 - 20070099222 - Methods and compositions for labeling nucleic acids The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include ... 05/03/07 - 20070099221 - Method of analyzing nucleic acid An object of the invention is to avoid any possibility of error caused by a nucleic acid used as a standard, a probe, or probe spot, etc. or enable correction thereof, to analyze the frequency of gene expressions with high reproducibility, and to analyze any change of primary structure in ... 05/03/07 - 20070099220 - Organic salt additives for nucleic acid amplification The present invention is directed to the use of a benzimidazolium compound comprising a side chain at at least one of its N-residues, said chain being either a Cn-alkyl or a substituted Cn-alkyl, characterized in that preferably n is ≧3, as an additive for a nucleic acid amplification reaction. ... 05/03/07 - 20070099219 - Systems and methods for treating, diagnosing and predicting the occurence of a medical condition Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on ... 05/03/07 - 20070099218 - Light transmitted assay beads A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling ... 05/03/07 - 20070099217 - Method for stress evaluation The molecular reaction mechanism that associates the clock gene with stress is elucidated based on the finding that stress is accompanied by an increase in the expression level of Per1 gene in peripheral tissues, stress response does not change the circadian rhythm in peripheral tissues, and Per1 gene increases in ... 05/03/07 - 20070099216 - Mutant endonuclease A novel mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but showing a specific activity. The present invention relates to a mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but having a specific activity, to a gene coding for the endonuclease V, to a ... 05/03/07 - 20070099215 - Novel bak binding protein, dna encoding the protein, and methods of use thereof The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to ... 05/03/07 - 20070099214 - Identification of a pin specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer The invention relates to nucleic acids encoding a mammalian ABCA5 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, PIN. Further, the invention relates to diagnostic assays for identifying the DNA-binding protein ABCA5 (also known as PIN-1). The invention ... 05/03/07 - 20070099213 - Corynebacterium glutamicum genes encoding novel proteins Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/03/07 - 20070099212 - Consecutive base single molecule sequencing The invention provides methods for sequencing polynucleotide molecules using single molecule sequencing techniques, where a plurality of labeled nucleotides are incorporated consecutively into an individual primer molecule. ... 05/03/07 - 20070099211 - Detection of nucleic acid amplification Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence ... 05/03/07 - 20070099210 - Methods of labelling polynucleotides with dibenzorhodamine dyes including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine ... 05/03/07 - 20070099209 - Compositions and methods for treating and diagnosing cancer The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem ... 05/03/07 - 20070099208 - Single molecule arrays for genetic and chemical analysis Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, ... 05/03/07 - 20070099207 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 05/03/07 - 20070099206 - Compositions for detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include an RNA polymerase, a FEN nuclease, and a probe. ... 05/03/07 - 20070099205 - Compositions for detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions include a reverse transcriptase, a nuclease, an upstream primer and downstream probe. ... 05/03/07 - 20070099204 - Identification and quantification of a plurality of biological (micro)organisms or their components Disclosed is a system and method conducting real-time PCR. Capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is in ... 05/03/07 - 20070099203 - Biomarkers for neurodegenerative disorders The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the pattern of gene product expression from the sample to a library of gene ... 05/03/07 - 20070099202 - Methods and compositions for assessment of pulmonary function and disorders The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer. Nucleotide probes and primers, kits, and microarrays ... 05/03/07 - 20070099201 - Methods for detecting and quantifying binding and inhibition of binding of species to nucleic acids The invention features methods for detecting and quantifying the binding or inhibition of binding of species to biopolymers, e.g., nucleic acids. The invention is based on the use of probes that have magnetic relaxation properties that are affected by the presence of paramagnetic metal ions, e.g., Mn2+. Any class of ... 05/03/07 - 20070099200 - High throughput mobility shift The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and ... 05/03/07 - 20070099199 - Methods and compositions for treating cervical cancer The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid ... 05/03/07 - 20070099198 - Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provide methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts ... 05/03/07 - 20070099197 - Methods of prognosis of prostate cancer The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis ... 05/03/07 - 20070099196 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas The invention relates relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). ... 05/03/07 - 20070099195 - Methods and compositions for separating nucleic acids from a solid support Methods and compositions for separating nucleic acids from a solid support are provided. In the subject methods, a silica containing solid support having nucleic acids immobilized on a surface thereof is subjected to cleavage conditions, such that a fluid cleavage product that includes nucleic acids and silica is produced. The ... 05/03/07 - 20070099194 - Quality control of probe attachment on electrodes The present disclosure relates to methods of quantifying nucleic acid molecules immobilized on an electrode of an electrochemical assay chip. Such quantification can be used in testing and quality control of assay chips. Materials and instrumentation useful in performing such techniques are also disclosed. ... 05/03/07 - 20070099193 - Probe/target stabilization with add-in oligo The invention relates to analyzing a sample containing small RNAs. In exemplary embodiments, the sample is contacted with an array in the presence of an add-in oligo. In typical embodiments, probes on the array include regions that are complementary to small RNAs and regions that are complementary to the add-in ... 05/03/07 - 20070099192 - Denaturing size-fractionation in analysis of small rna The invention relates to analyzing a sample containing polynucleotides having small RNA binding sites. In exemplary embodiments, the sample is contacted with a size-fractionation medium under denaturing conditions to provide a fraction containing small RNA. The fraction containing small RNA is then contacted with an array under conditions sufficient to ... 05/03/07 - 20070099191 - Methods and systems for evaluating the length of elongated elements Systems and methods are disclosed for evaluating the length of elongated elements in a sample. The disclosed systems and methods may include using a direct current stimulus to determine a direct current base length region corresponding to at least a portion of the sample. Furthermore, the disclosed systems and methods ... 05/03/07 - 20070099190 - Method for distinguishing leukemia subtypes Disclosed is a method for distinguishing leukemia subtypes t(15;17), t(8;21), inv(16), inv(3), complex aberrant karyotype (CA), AML-MLL, normal karyotype (NK), AML-other (trisomy 8, trisomy 11, trisomy 13, monosomy 7, del(5q), del(9q), t(6;9); del(20q) and del(12p) and trisomy 4), ALL-MLL, ALL-Ph+, ALL-t(8;14), T-ALL, other B-lineage (OBL), CML, normal-BM, and/or CLL in ... 05/03/07 - 20070099189 - Method and apparatus for detecting substances or analytes from the analysis of one or more samples The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample ... 05/03/07 - 20070099188 - Novel method for finding mutations caused by the insertion of repeated dnas The present invention provides a method of for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations in a plant or mammalian subject. ... 05/03/07 - 20070099187 - Nucleic acid array A nucleic acid array is provided that can efficiently perform analysis, and further, can estimate the number of expressions of amino acid mutations for all cases by use of a smaller number of arrays. The nucleic acid array has a plurality of oligonucleotides immobilized on a substrate, wherein the oligonucleotide ... 05/03/07 - 20070099186 - Methods and means for the treatment of disorders associated with cellular senescence This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided ... 05/03/07 - 20070099185 - Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein The present invention provides methods for the screening and identification of agents from a large library of molecular structures that can alter the cleavage of amyloid precursor protein (AP). Agents identified by the methods of the present invention that modify the cleavage of APP can be used in the treatment ... 05/03/07 - 20070099184 - Nucleic acid amplication utilizing intermediate duplexes This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides (see FIGS. 1-7). ... 04/26/07 - 20070092909 - Molecular markers for identification of fat and lean phenotypes in chickens The invention provides molecular methods of screening chickens to determine those more likely to have a lean or fat phenotype by identifying the presence of at least one polymorphism in genetic material of a chicken in the thyroid hormone repressible gene (THRG) or its 3′ untranslated region (SEQ ID NO: ... 04/26/07 - 20070092908 - Renaturation, reassociation, association and hybridization of nucleic acid molecules The present invention features methods and compositions for the renaturation, hybridization, association, or reassociation of nucleic acids that combines both acceleration of the reaction rate and improved specificity. ... 04/26/07 - 20070092907 - Methods of screening compound probes Briefly described, embodiments of this disclosure include methods for identifying compound probe candidates, methods of screening compound probe candidates, methods of preparing molecular imaging probes, high throughput methods for identifying molecular imaging probes in a library, and the like. ... 04/26/07 - 20070092906 - Method and system for delivering nucleic acid into a target cell Controlled delivery of nucleic acid into adhered of cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complimentary DNA binding interactions with an oligonucleotide linker. ... 04/26/07 - 20070092905 - Compositions and methods for analyzing immobilized nucleic acids The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using ... 04/26/07 - 20070092904 - Method for preparing limiting quantities of nucleic acids The present invention relates generally to the amplification of nucleic acids. More specifically, the present invention facilitates amplification of total RNA for a variety of purposes, including analysis utilizing nucleotide assays, constructing cDNA libraries, in situ hybridization, and TaqMan. Additionally, the present invention facilitates amplification of total RNA isolated from ... 04/26/07 - 20070092903 - One-color microarray analysis methods, reagents and kits Microarray platforms for performing one-color and two color analyses using a single platform are provided. Methods of using the microarray platforms and analyzing data obtained from such microarrays are also provided. ... 04/26/07 - 20070092902 - Methods for detection of promoter polymorphism in ugt gene promoter The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon ... 04/26/07 - 20070092901 - Automated sample-to-microarray system An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a ... 04/26/07 - 20070092900 - Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer Methods and kits for diagnosing and characterizing breast cancer or a susceptibility to breast cancer are described herein. Diagnosis and characterization methods comprise detecting the BARD1 Cys557Ser allele or a haplotype comprising the BARD1 Cys557Ser allele in patients with or without a familial predisposition to cancer. The methods described herein ... 04/26/07 - 20070092899 - Multiple displacement amplification with blocker dna A method of whole genome amplification of a nucleic acid sample comprising providing a starting template of the nucleic acid sample, bringing the template together with blocking DNA, bringing the template together with DNA polymerase, and multiple displacement amplification of the template. The method can be used with a starting ... 04/26/07 - 20070092898 - Detection of multiple anti-viral antibodies The present invention relates to methods and kits for the diagnosis and monitoring of hepatitis C virus (HCV) infection and/or Kaposi's sarcoma herpesvirus infection (KSHV) in a subject, as well as other infectious diseases and agents. In particular, the present invention relates to the diagnosis and monitoring of infectious disease ... 04/26/07 - 20070092897 - Labeled probe bound object, method for producing the same and method for using the same A method for labeling an object, which is effective when multiple types of labels are given as necessary even to a very small object such as a fine particulate substrate for use in fixation of biological substances such as probe molecules or nucleic acid primers that are used for a ... 04/26/07 - 20070092896 - Extreme thermophile single-stranded dna binding mutant protein, and nucleic acid isothermal amplification method of use thereof The invention establishes a technology that allows non-specific amplification to be inhibited during nucleic acid amplification in an isothermal amplification reaction, such that the amplification efficiency is increased. The invention is a extreme thermophile single-stranded DNA binding mutant protein, having an amino acid sequence that expresses a function that can ... 04/26/07 - 20070092895 - Methods for identifying genes that increase yeast stress tolerance, and use of these genes for yeast strain improvement Disclosed are methods for identifying genes that increase stress tolerance of yeast, list of identified genes, and use of these genes for improving yeast strains for better survival and performance during ethanolic fermentation. ... 04/26/07 - 20070092894 - Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297. ... 04/26/07 - 20070092893 - Methods and compositions for identifying cancer-related biomarkers The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092892 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092891 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092890 - Methods and compositions for detecting autoimmune disorders The invention provides methods and compositions useful for detecting autoimmune disorders. ... 04/26/07 - 20070092889 - Parkinson's disease-related disease compositions and methods Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions. ... 04/26/07 - 20070092888 - Diagnostic markers of hypertension and methods of use thereof The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific ... 04/26/07 - 20070092887 - Methods for generating polynucleotides having desired characteristics by iterative selection and recombination A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to ... 04/26/07 - 20070092886 - Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease Polynucleotide sequences are provided that correspond to genes that are differentially expressed in atherosclerotic disease conditions. Methods for using these sequences to detect gene expression and/or for transcriptional profiling in mammals are also provided. The polynucleotide sequences of the invention may be used, for example, to diagnose atherosclerotic disease, to ... 04/26/07 - 20070092885 - Secreted proteins The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. ... 04/26/07 - 20070092884 - Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based dna library: application to the detection of mycobacteria A method for detecting Mycobacterium tuberculosis involves contacting a biological sample with the product of expression of at least one ORF contained in a polynucleotide present in Mycobacterium tuberculosis and absent in Mycabacterium bovis BCG; and detecting whether an immunological complex is formed between the product thereof and antibodies contained ... 04/26/07 - 20070092883 - Methylation specific multiplex ligation-dependent probe amplification (ms-mlpa) An improved multiplex ligation-dependent amplification method is disclosed for detecting the presence of specific methylated sites in a single stranded target nucleic acid, while simultaneously, the quantification of the target nucleic acid sequence can be performed, using a plurality of probe sets of at least two probes, each of which ... 04/26/07 - 20070092882 - Analysis of microrna Methods are described in which a sample containing miRNA is contacted with an array having a probe set, followed by interrogating the array to assess binding to the probe set. Probes, probe sets, arrays comprising a probe set, and kits incorporating the probe sets are also described. ... 04/26/07 - 20070092881 - Gene markers of tumor metastasis The invention concerns the study of tumor metastasis in a NOD/SCID/γcnull transgenic mouse model and the identification of tumor markers, including markers of tumors with high metastatic potential, using information obtained in this mouse model. ... 04/26/07 - 20070092880 - Invasive cleavage reaction with electrochemical readout A universal tag assay is disclosed wherein at least one invasive cleavage reaction (ICR) is used to generate tagged molecules having identifier tags corresponding to target nucleotide sequences, and further wherein hybridization of any tagged molecule with a complementary detection probe on a universal detector indicates the presence of the ... 04/26/07 - 20070092879 - Fluoresence-based dna primase assays The present invention provides methods for assaying the activity of DNA primases and methods for screening for compounds that modulate the activity of DNA primases. ... 04/26/07 - 20070092878 - In vitro method to detect bladder transitional cell carcinoma The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop ... 04/26/07 - 20070092877 - Bcrm-1 genes and uses thereof A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines ... 04/26/07 - 20070092876 - Method and system for cell and/or nucleic acid molecules isolation The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii) ... 04/26/07 - 20070092875 - Map2k6 as modifier of branching morphogenesis and methods of use Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided. ... 04/26/07 - 20070092874 - Plasma or serum marker and process for detection of cancer This disclosures provides, in one aspect, a method for detecting non-clinically diagnosed cancer in a patient. In one embodiment, the method includes extracting blood serum or plasma from the patient, and then detecting beta-catenin RNA in the blood serum or plasma. In addition, in this embodiment, the method includes determining ... 04/26/07 - 20070092873 - Digital identification of genetic materials and methods for acquiring data for it The present invention relates to methods using HIPK1 sequences for use in diagnosis and treatment of lymphoma and leukemia. In, addition, the present invention describes the use of these compositions for use in screening methods. ... 04/26/07 - 20070092872 - Apparatus and method for sequencing a nucleic acid Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides. ... 04/19/07 - 20070087379 - Ys68 gene involved in primitive hematopoiesis A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding ... 04/19/07 - 20070087378 - Polynucleotide and polypeptide fat metabolism regulators and uses thereof In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat ... 04/19/07 - 20070087377 - Methods and compositions for reverse translation A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse ... 04/19/07 - 20070087376 - Splice variants of pre-mrna transcripts as biomarkers in idiopathic neurodegenerative diseases The present invention discloses a method to discover biomarkers indicative of an idiopathic neurodegenerative disease in a mammalian subject and biomarkers indicative of an idiopathic neurodegenerative disease in the mammalian subject. The biomarker comprises a splice variant mRNA of a precursor-messenger RNA (pre-mRNA) transcript of a gene in the mammalian ... 04/19/07 - 20070087375 - Methods and compositions for treating cancer using 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to ... 04/19/07 - 20070087374 - Optimization of immunomodulatory properties of genetic vaccines This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose. ... 04/19/07 - 20070087373 - Optimization of immunomodulatory properties of genetic vaccines This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose. ... 04/19/07 - 20070087372 - Isolated ductal fluid sample A sample for diagnosis of breast cancer can be prepared by isolating a ductal fluid sample from one duct of a breast of a patient. The isolated ductal fluid is not mixed with ductal fluid from any other duct of the breast. Generally the target duct is not spontaneously discharging. ... 04/19/07 - 20070087371 - Zinc finger domains and methods of identifying same Disclosed is an in vivo selection method for identifying zinc finger domains that recognize any given target site. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites. ... 04/19/07 - 20070087370 - Microarray probe tm matching by selective destabilization Methods and systems for designing oligonucleotide probes for use in microarray applications are provided herein. The described methods use duplex melting temperature (Tm) matching to destabilize the hybridization oligonucleotide probes to non-target sequences as compared to a target nucleotide sequence. Nucleic acid arrays containing probes selected by the described methods ... 04/19/07 - 20070087369 - Method for the isolation of rna from biological sources Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding ... 04/19/07 - 20070087368 - Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants A system for analyzing alternative splice variant sequences is described, comprising an input manager for receiving alternative splice variant sequences that are identified by one or more probe sets, a correlator that correlates functional domains with each of the alternative splice variant sequences and an associater that associates putative functions ... 04/19/07 - 20070087367 - Method and apparatus for combinatorial chemistry A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be ... 04/19/07 - 20070087366 - Functional mutant loxp sequences and uses thereof The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different ... 04/19/07 - 20070087365 - Methylation markers for diagnosis and treatment of ovarian cancer Twenty-three markers are provided which are epigenetically silenced in ovarian cancers. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor-suppressor ... 04/19/07 - 20070087364 - In vitro erythroid micronucleus assay for genotoxicity The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro. ... 04/19/07 - 20070087363 - Therapeutic methods, compounds and compositions The invention provides methods of treating, preventing, delaying the onset, slowing the progression, or reversing the symptoms of Alzheimer's disease and other neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide. The invention also provides compounds that reduce the production or secretion of the Aβ42-peptide by ... 04/19/07 - 20070087362 - Polony fluorescent in situ sequencing beads Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided. ... 04/19/07 - 20070087361 - Solid support assay systems and methods utilizing non-standard bases Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target ... 04/19/07 - 20070087360 - Methods and compositions for detecting nucleotides The present teachings generally relate to methods and materials for the detection of target nucleotides and/or the methylation state of target nucleotides. ... 04/19/07 - 20070087359 - Detecting mutations in the feline cardiac myosin binding protein c gene associated with hypertrophic cardiomyopathy in cats The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy in cats, particularly domesticated cats, and more particularly Maine Coon cats. The methods include detecting the presence or absence of a mutation in the feline MYBPC gene, and identifying feline subjects that ... 04/19/07 - 20070087358 - Methods for diagnosing cancer based on dna methylation status in nbl2 The present invention relates to methods for diagnostic or prognostic assay for cancer based on analysis of altered methylation status at specific CpG dinucleotide sequences within the epigenetic marker, NBL2. The methods of the invention comprise determining the methylation status of a subregion of genomic CpG dinucleotide sequences within the ... 04/19/07 - 20070087357 - Lateral flow device with onboard reagents Devices, methods and kits for conducting an assay to determine the presence or amount of an analyte in a fluid sample. The device includes a sample application element and a flow path matrix that facilitates fluidic flow by capillary action. The sample application element includes a non-absorbent or absorbent carrier ... 04/19/07 - 20070087356 - In situ assembling of protein microarrays The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds ... 04/19/07 - 20070087355 - Comparative genomic hybridization assays and compositions for practicing the same Comparative genomic hybridization (CGH) assays and compositions for use in practicing the same are provided. Aspects of the methods include first preparing genomic templates from an initial genomic source by using precursors of circular template nucleic acids, e.g., padlock probes. The precursors include first and second domains that are at ... 04/19/07 - 20070087354 - Lentiviral vector-based vaccine Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed. ... 04/19/07 - 20070087353 - Microarray biochemical reaction device The microarray biochemical reaction device of this invention integrates microfluidic trenches with a microarray to form a serpentine microchannel passing through all DNA probes provided in the microarray. A sample solution is introduced into the microchannel and scrambled into discrete plugs to induce droplet mixing. The discrete plugs are then ... 04/19/07 - 20070087352 - Inhibitors for androgen antagonist refractory prostate cancer The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed ... 04/19/07 - 20070087351 - Orotate transporter encoding maker genes A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a ... 04/19/07 - 20070087350 - Use of a mutation in the braf gene for the determination of the malignancy of melanoma cells The invention relates to the use of oligonucleotide probes comprising exon 15 of the BRAF gene or a part thereof comprising codon 599 for the detection of the malignancy of melanoma cells. ... 04/19/07 - 20070087349 - Highly parallel template-based dna synthesizer The invention relates to a template-based method for preparing nucleic acid double strands. ... 04/19/07 - 20070087348 - System and method for carrying out multiple binding reactions in an array format A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at ... 04/19/07 - 20070087347 - Dose-dependent promoter originating in humans It was found that a DNA consisting of a nucleotide sequence as set forth in SEQ ID NO: 1 having one sequence (SEQ ID NO: 2) unit, has a function of an initiator or a promoter. Therefore, it is provided a DNA consisting of a nucleotide sequence as set forth ... 04/19/07 - 20070087346 - Orthogonal gene switches The present invention relates to an orthogonal gene switch for regulating the expression of a desired gene. The gene switch comprises a chimeric transcription factor that does not respond to endogenous ligands, and a ligand that is capable of activating the chimeric transcription factor but not endogenous transcription factors. The ... 04/19/07 - 20070087345 - Assays for the direct measurement of gene dosage The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy. ... 04/19/07 - 20070087344 - Methods for characterizing signaling pathways and compounds that interact therewith The genes in a signaling pathway can be identified by over or under-expressing each member of a set of genes to be grouped in signaling pathways and measuring parameters under stimulatory conditions. Genes in a common signaling pathway give similar parameter profiles under such conditions. Moreover, the interactions between signaling ... 04/19/07 - 20070087343 - Method of detecting gene expression and kit and apparatus to be used therein In an animal embryo or tissue, the following wholeamount treatment is carried out so that gene expression is detected. First, a sample such as an embryo or a tissue is fixed and then pretreated by acetylating an amine with acetic anhydride and eliminating lipids by using xylene. Next, in situ ... 04/19/07 - 20070087342 - Secreted proteins The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. ... 04/12/07 - 20070082361 - Dna and proteins or peptides specific of bacteria of the neisseria meningitidis species, methods for obtaining them and biological applications thereof The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp ... 04/12/07 - 20070082360 - Magnetic pigment Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification. ... 04/12/07 - 20070082359 - Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay Methods of identifying a compound that inhibit, enhance and/or misdirect assembly of a viral capsid include providing fluorescently-labeled capsid polypeptides labeled with a fluorescent dye that changes fluorescence at high concentration, wherein assembly of the capsid polypeptides into the viral capsid results in juxtaposition of at least one of the ... 04/12/07 - 20070082358 - Sequencing by synthesis based ordered restriction mapping The present invention is directed to a method for de novo assembly of genomic sequence information comprising the combination optical whole genome restriction mapping and ultra high throughput pyrosequencing. ... 04/12/07 - 20070082357 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan; and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive ... 04/12/07 - 20070082356 - Methods of evaluating transplant rejection The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell ... 04/12/07 - 20070082355 - Method for polymerase chain reactions with use of a dna polymerase with proofreading properties The present invention concerns a method for a polymerase chain reaction, in which a template nucleic acid, at least one primer, deoxyribonucleoside triphosphates as well as a DNA polymerase with proofreading activity are used. In addition, according to this invention, at least one target substrate is added to the polymerase ... 04/12/07 - 20070082354 - method for isolating rna A method for isolating RNA from RNA containing samples wherein the RNA containing sample is treated with at least one DNase and/or another enzyme like proteases or collagenases for purification of RNA in presence of a complex of ribonucleosides and the oxovanadyl ion which is capable of inhibiting RNases present ... 04/12/07 - 20070082353 - Genetic marker selection program for genetic diagnosis, apparatus and system for executing the same, and genetic diagnosis system There is provided a marker selection program for selecting a marker for use in genetic diagnosis. In the program, analysis is carried out by using at least two specimen databases which respectively store data of specimens belonging different populations. By carrying out analysis without integrating all specimen data into single ... 04/12/07 - 20070082352 - Microscopy tip Disclosed is a tip for use in atomic force microscopy. The tip includes a substrate and a three-dimensional, double-stranded nucleic acid structure attached thereto. The nucleic acid structure may have a single-stranded nucleic acid attached thereto, such as an aptamer sequence. In use, the tip having the nucleic acid structure ... 04/12/07 - 20070082351 - Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy ... 04/12/07 - 20070082350 - Assay and method for diagnosing and treating alzheimer's disease I Methods and kits for diagnosing Alzheimer's disease and/or incipient Alzheimer's disease are disclosed. The methods and kits of the invention utilize a set of genes and their encoded proteins that are shown to be correlated with incipient Alzheimer's disease. ... 04/12/07 - 20070082349 - Photocrosslinking probes and uses of the same A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products ... 04/12/07 - 20070082348 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 04/12/07 - 20070082347 - Gene variants and use thereof Variants in TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 and AMFR genes are disclosed which are useful as biomarkers for predicting the TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 or AMFR gene ... 04/12/07 - 20070082346 - Homogeneous detection method The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is ... 04/12/07 - 20070082345 - Secretory protein or membrane protein Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides ... 04/12/07 - 20070082344 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 04/12/07 - 20070082343 - Method for the control of segment-wise enzymatic duplication of nucleic acids via incomplete complementary strands The invention relates to a new method for the control of enzymatic duplication of nucleic acids by the section via incomplete complementary strands. Fields of application of the invention are research, medical practice, gene-based analytics of biotechnological, agricultural and foodstuff products as well as criminology. ... 04/12/07 - 20070082342 - Near-patient module for analyte detection system In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The ... 04/12/07 - 20070082341 - Human phospholipases The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME. ... 04/12/07 - 20070082340 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for ... 04/12/07 - 20070082339 - Methods and compositions for screening for hdac inhibitory activity The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a ... 04/12/07 - 20070082338 - Cgh array quality assessment Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across ... 04/12/07 - 20070082337 - Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced ... 04/12/07 - 20070082336 - Methods for protein labeling based on acyl carrier protein A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof. ... 04/12/07 - 20070082335 - Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction The invention provides methods and compositions based on the interaction of TSG101 and VPS28 proteins for treatment of viral infections, including HIV infections. The invention also provides TSG101-VPS28 based methods and compositions for evaluation and screening of drugs which can be used for treating viral infections. ... 04/12/07 - 20070082334 - Nucleotide and protein sequence of mammastatin and methods of use A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and ... 04/12/07 - 20070082333 - Thermophilic dna polymerases from thermoactinomyces vulgaris The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, ... 04/12/07 - 20070082332 - Molecular cardiotoxicology modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of ... 04/05/07 - 20070077591 - Novel polypeptide A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed. ... 04/05/07 - 20070077590 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of ... 04/05/07 - 20070077589 - Altered recombinases for genome modification The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also ... 04/05/07 - 20070077588 - Non-fluorescent energy transfer The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these donor moieties typically entail reduced background fluorescence relative to applications that involve conventional fluorescent donor moieties. In addition ... 04/05/07 - 20070077587 - Method of detecting a biopolymer and device for the same Provided is a method of achieving a simple, quick, and highly accurate detection and measurement of a biopolymer, and to provide a device for this purpose. To this end, a method of detecting a biopolymer utilizing two kinds of solvent phases different in property from each other, including steps of: ... 04/05/07 - 20070077586 - Maternal chelation for embryo, fetal, and infant benefit This invention teaches the use of chelating agents to diagnose and treat metal toxins in a patient. Chelation agents are given to the mother for the benefit of the baby. Metal toxins such as lead, arsenic, mercury, tin, antimony, aluminum and others are known to cause miscarriages, birth defects, maldevelopment ... 04/05/07 - 20070077585 - Compositions and methods for il13 biomarkers Compositions and methods are provided for measuring and determining biomarkers for IL-13. ... 04/05/07 - 20070077584 - Adenovirus status as a predictor of body composition change, disease status, and treatment outcomes Infection with obesifying adenoviruses in animals and humans may be used to predict changes in body weight and disease status. More particularly, infection with certain adenoviruses, such as adenovirus type 36 (Ad-36) and adenovirus type 37 (Ad-37) may cause removal of the normal equilibrium factors that control fat cell metabolism ... 04/05/07 - 20070077583 - Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance Disclosed are methods for detecting a neoplasm and/or chemotherapeutic drug resistance or angiogenic potential in neoplastic cells by detecting an increase in the expression of α-enolase in such cells, or in the case of metastatic potential on the surface of such cells, as compared to the level of expression of ... 04/05/07 - 20070077582 - Method for quantitative detection of short rna molecules Described herein are approaches to the detection and quantitation of short RNAs in a biological sample. The methods permit the detection and quantitation of individual species of short RNA in a nucleic acid sample, both singly and in a multiplex format that permits the determination of expression levels for two ... 04/05/07 - 20070077581 - Oncoprotein protein kinase An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and Threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of deterction of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects ... 04/05/07 - 20070077580 - Biochemical treatment apparatus and method comprising liquid handling mechanism Nucleic acid solution, magnetic particles solution and primer or eluate are moved between a lot of wells provided in reaction/storage vessel 3 by pipette device 40 to perform the first PCR, purification and the second PCR. In the time point where the first PCR and purification end, pipette tip 42 ... 04/05/07 - 20070077579 - In vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements ... 04/05/07 - 20070077578 - Diagnosis of (a risk of ) disease and monitoring of therapy The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from the individual comprises an expression product of AC133 in ... 04/05/07 - 20070077577 - Proliferation markers in clinical practice and their use for cancer prognosis or diagnosis The invention relates to a method for assessing the proliferative state of cells in a human or non human biological sample, comprising using Chromatin Assembly Factor-1 (CAF-1 in short) subunits as proliferation markers. Application for cancer prognosis or diagnosis and monitoring tumor response in therapy. ... 04/05/07 - 20070077576 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 04/05/07 - 20070077575 - Use of rna polymerase as an information-dependent molecular motor Materials and methods are described in which the information dependence of RNA polymerase is employed to enable its use as a molecular motor adaptable for movement within DNA grid arrays and to actuate, move, position or alter cargo such as physical structures and normally inanimate substances and objects. ... 04/05/07 - 20070077574 - family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and ... 04/05/07 - 20070077573 - Method for extracting dna from sample of organism A method in which DNA is extracted from a precious sample of organism simply and efficiently without being contaminated by impurities is provided. The method for extracting DNA comprises of: 1) a process for pretreatment having; a procedure for obtaining fragments by using a whole sample of organism of hard ... 04/05/07 - 20070077572 - Compositions and methods for in vitro sorting of molecular and cellular libraries The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulsion includes a continuous ... 04/05/07 - 20070077571 - Methods and apparatus for identifying allosterically regulated ribozymes Compositions and methods are provided to use regulatable aptazymes for controlling gene expression and in assays to detect the presence of ligands or to detect activation by an effector of an aptazyme bound to a solid support such as a substrate or multi-well plate. Regulatable aptazymes are ribozymes that are ... 04/05/07 - 20070077570 - Multiplexed amplification of short nucleic acids The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of a zip-coded stem-loop reverse transcription primer, along with a PCR-based pre-amplification reaction that comprises a zip-coded forward primer. Detector probes ... 04/05/07 - 20070077569 - Isomaltulose synthases, polynucleotides encoding them and uses therefor The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and ... 04/05/07 - 20070077568 - Process for preparing high stability, high activity coatings and processes for using same A process for preparing high stability, high activity biocatalytic coatings is disclosed attachable to various materials and fibers, and processes for using same. The process involves attaching crossslinked enzyme aggregates to various materials and fibers forming a biocatalytic coating characterized by high biocatalytic activtity and high stability. The coated materials ... 04/05/07 - 20070077567 - High stability, high activity materials and processes for using same The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high biocatalytic activity and stability useful in heterogeneous environment. These new materials provide a new biocatalytic immobilized enzyme system with applications in bioconversion, bioremediation, biosensors, ... 04/05/07 - 20070077566 - High stability, high activity coatings and processes for using same The present invention relates to a high stability, high activity coating and processes for using the same. The coating has high biocatalytic activity and stability useful on surface of various materials and fibers, e.g., polymer fibers applicable in heterogeneous environments. In one illustrative approach, enzyme “seed” are covalently attached to ... 04/05/07 - 20070077565 - Process for preparing high stability, high activity materials and processes for using same A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and enzyme aggregate providing a material or fiber with high biocatalytic activity and stability useful in heterogeneous environments. In one illustrative ... 04/05/07 - 20070077564 - Reactive surfaces, substrates and methods of producing same Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses. ... 04/05/07 - 20070077563 - Method of searching for functional nucleotide molecule A universal method of searching for a nucleic acid capable of effectively inhibiting gene expression; a nucleic acid construct to be used in this method; a vector; and a kit for the above method. This method is characterized in that a nucleic acid construct, which is a nucleic acid construct ... 04/05/07 - 20070077562 - Rapid nucleic acid isolation method and compositions A method of isolating RNA from a biological specimen is provided, whereby a biological specimen is contacted with an admixture of (i) a mono-phasic solution of phenol and guanidine isothiocyanate and (ii) a lysis buffer under conditions and for a time appropriate to form a homogenate. Next, the homogenate is ... 04/05/07 - 20070077561 - Detection of transgenes of genetically modified organisms using pyro luminescence The present application provides a method for identifying the presence of a transgene of a genetically modified organism in a sample wherein the nucleic acid sequence of the transgene is replicated and detected as the release of PPi from the deoxynucleotide triphosphate precursors consumed in the replication reaction. This pyro ... 04/05/07 - 20070077560 - Method and system for rapidly conferring a desired trait to an organism A method is provided for regulating the conversion rate of a hereditary trait of a cell, comprising the step of regulating the error-prone frequency of gene replication of the cell. A method is provided for producing a cell having a regulated hereditary trait, comprising the step of (a) regulating an ... 04/05/07 - 20070077559 - Newcastle disease virus administration A mammalian subject having a tumor is treated by a method comprising administering an effective amount of a Newcastle disease virus, wherein the virus is administered to the subject in one or more cycles; and at least one cycle comprises administering sequentially one or more initial doses of from 1.8×1010 ... 04/05/07 - 20070077558 - Method for evaluating quality of beef such as taste and texture on the basis of genotype of stearoyl-coa desaturase We paid attention to stearoyl-CoA desaturase gene, and investigated the relation between this gene and the unsaturated fatty acid content in beef fat. As a result, we found that the unsaturated fatty acid content was associated with the genotype of this gene, classified according to several single nucleotide polymorphisms (SNPs) ... 04/05/07 - 20070077557 - Method for identifying type-1 interferon responsive ms patients by determining trail expression This invention relates to a method for identifying MS patients susceptible to type I-Interferon (IFN), in particular IFN-β, and for monitoring IFN therapy in MS patients by determining TRAIL gene and/or protein expression as a marker. ... 04/05/07 - 20070077556 - Tumor associated antigens and methods of using the same The present invention provides methods and compositions for the diagnosis of hyperproliferative disease and autoimmune disease. Tumor associated antigens, nucleic acids encoding them and antibodies to the tumor associated antigens are provided for the diagnosis of hyperproliferative disease, such as, for example, ovarian cancer, breast cancer, lung cancer, colorectal cancer, ... 03/29/07 - 20070072233 - Methods and systems for facilitating the diagnosis and treatment of schizophrenia A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy). ... 03/29/07 - 20070072232 - Identification of genetic components of drug response The present invention is concerned generally with the field of identifying an appropriate treatment regimen for a disease based upon genotype in mammals, particularly in humans. It is further concerned with the genetic basis of inter-patient variation in response to therapy, including drug therapy. Specifically, this invention describes the identification ... 03/29/07 - 20070072231 - Tumor suppressor gene A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells ... 03/29/07 - 20070072230 - Compositions, kits, and methods relating to the human fez1 gene, a novel tumor suppressor gene The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, ... 03/29/07 - 20070072229 - Method for isolation, amplification and quantitation of ribonucleic acid A cellular RNA isolation method comprising treating at least one nucleated cell with a composition comprising mild detergents such as non-ionic detergent(s), buffer(s), chelator(s), reducing agent(s), salt(s), and RNase inhibitor(s) to result in a cytoplasmic lysate and intact nucleus, then separating the cytoplasmic lysate containing RNA from the nucleus, and ... 03/29/07 - 20070072228 - Ercc2 polymorphisms This invention relates to diagnostic methods based upon a polymorphism in individuals indicative of an increased risk of breast carcinoma. More specifically, this invention relates to a method for diagnosis of an increased risk of breast carcinoma by screening for the presence of genetic polymorphisms in individuals, specifically in the ... 03/29/07 - 20070072227 - Gamma secretase notch biomarkers The present invention relates to biomarker indicators, including polypeptides, polynucleotides and small molecules, that measure γ-secretase mediated Notch processing. These indicators have utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized ... 03/29/07 - 20070072226 - Mining protein interaction networks One embodiment is a method including creating a protein interaction network including a plurality of protein IDs and a plurality of interactions between protein IDs, determining confidences of interactions of the protein interaction network, identifying a sub-network of the protein interaction network, and determining relevance of proteins of the sub-network ... 03/29/07 - 20070072225 - Antibodies with simultaneous subsite specificities to protein and lipid epitopes Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars ... 03/29/07 - 20070072224 - Diagnosis and treatment of tumor-suppressor associated disorders Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSLC1 and detecting the level of TSLC1 in the proliferating cell. TSLC1 is a single gene whose expression is reduced ... 03/29/07 - 20070072223 - Compositions and methods for purifying nucleic acids Described herein are compositions and methods for enriching a nucleic acid sample for target sequence(s). The compositions comprise an oligonucleotide attached to a solid support, directly or indirectly, wherein the oligonucleotide does not serve as a primer for a polymerase enzyme. ... 03/29/07 - 20070072222 - Fabp4 as biomarker for toxic effect The present invention relates to FABP4 as a marker for determining at least one toxic effect of a compound of interest and methods for determining same. ... 03/29/07 - 20070072221 - Methods to screen peptide display libraries using minicell display A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size ... 03/29/07 - 20070072220 - Non-fouling polymeric surface modification and signal amplification method for biomolecular detection An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first ... 03/29/07 - 20070072219 - Detection method of homologous sequences differing by one base on a microarray The present invention is related to a detection method and kit of homologous sequences differing by one base on a microarray. ... 03/29/07 - 20070072218 - Tumor suppressor killin The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies. ... 03/29/07 - 20070072217 - Xaf genes and polypeptides: methods and reagents for modulating apoptosis The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis. ... 03/29/07 - 20070072216 - Method for diagnosis of glioma: distinguishging between progressive and de novo types The present invention relates to a method for identifying the type of glioblastoma multiforme in mammals, preferably human subjects. More particularly, it relates to a kit for characterizing progressive glioma in mammals, preferably human subjects. More particularly, it relates to a kit for distinguishing primary and secondary glioblastoma multiforme (GBM) ... 03/29/07 - 20070072215 - Nucleic acid-based logic circuits This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein. ... 03/29/07 - 20070072214 - Detection of truncation mutations by mass spectrometry This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference. ... 03/29/07 - 20070072213 - Method and apparatus for implementing non-destructive quality control of substrates and printed biological microarrays, and for implementing quality control and visualizing gel-based microarrays prepared by dispensing gel-forming composition on solid surf A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of ... 03/29/07 - 20070072212 - Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material The use of artificially-generated nucleic acid coded markers to monitor nucleic acid amplification and sequencing reactions designed to detect or analyze biological samples. The markers generally include, along with a unique sequence preferably including coded section designed to represent one or more factors of interest, primer annealing sequences so that ... 03/29/07 - 20070072211 - Asymmetric pcr coupled with post-pcr characterization for the identification of nucleic acids The present invention provides methods, compositions, and kits for quantification and identification of target nucleic acid sequences, either in pure solutions or from mixtures of various nucleic acids. In other aspects, the invention provides compositions and methods for HCV genotyping. ... 03/29/07 - 20070072210 - Use of brca1-associated protein to treat and screen for dna damage and to identify therapeutics that promote a dna damage response The present invention relates to the use of a BAAT1 protein to screen for potential therapeutics that promote a DNA damage response or treat breast cancer. The present invention also relates to a method of treating DNA damage or breast cancer in a subject by administering a compound that increases ... 03/29/07 - 20070072209 - Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases Aspects of the present invention use gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the ... 03/29/07 - 20070072208 - Nucleic acid analysis by random mixtures of non-overlapping fragments The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such ... 03/29/07 - 20070072207 - Production of vaccines Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing ... 03/29/07 - 20070072206 - Strong pcr primers and primer cocktails The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of diverse sequences in chaperonin-60 based PCR product libraries derived from complex templates. In previous cpn60-based and 16S rDNA-based studies of ... 03/29/07 - 20070072205 - Nanomaterial error correction The present invention makes use of the discovery that proofreading and error-correction techniques common in biological systems may be adapted to material science. Enzymes and aptamers are adapted to proofread and correct defects in nanoparticle structures. ... 03/29/07 - 20070072204 - Compositions and methods for cancer diagnosis and treatment The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy. ... 03/29/07 - 20070072203 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed. ... 03/29/07 - 20070072202 - Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an ... 03/29/07 - 20070072201 - Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results An approach and methods are provided for obtaining improved information and results concerning the functional homogeneity and functional characteristics of a chemically synthesized or biologically synthesized nucleic acid oligomer of any type, and for obtaining improved information and results concerning the functional homogeneity and functional characteristics of the oligomer under ... 03/29/07 - 20070072200 - Method for determining co-receptor selectivity of human immunodeficiency virus-1 Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop ... 03/29/07 - 20070072199 - Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces The present invention is directed to methods for immobilizing molecules on siliceous and metallic surfaces. Molecules are immobilized on siliceous or metallic surfaces by stable covalent linkages that are capable of withstanding prolonged use and elevated temperatures. Further, the methods of the present invention describe less-complicated chemistries for the immobilization ... 03/29/07 - 20070072198 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds. ... 03/29/07 - 20070072197 - Microtags for detection and identification of materials A customized microtag identifier has a custom synthesized polynucleic acid having a known sequence of bases, a recovery compound, and a protective coat; effective to identify said custom synthesized polynucleic acid, ... 03/29/07 - 20070072196 - Fluorescent nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others. ... 03/29/07 - 20070072195 - Bio-commemorative article incorporating amplified genetic material A combination of amplified genetic material from an individual or other organism with an inanimate article of manufacture to produce a bio-commemorative article is disclosed. The amplified genetic material is preferably produced from a polymerase chain reaction process. The amplified genetic material is coated onto the inanimate article of manufacture, ... 03/29/07 - 20070072194 - Global transcription machinery engineering The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. ... 03/29/07 - 20070072193 - Ligand arrays having controlled feature size, and methods of making and using the same Methods and compositions for producing a solid support having a ligand immobilized on a surface thereof, e.g. a ligand array, are provided. Aspects of the methods include: providing a solid support having a bounded feature location on a surface thereof, where the bounded feature location includes a region of the ... 03/29/07 - 20070072192 - Novel polypeptides encoded by essential bacterial genes The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides. ... 03/29/07 - 20070072191 - Infectious pestivirus pseudo-particles containing functional erns, e1, e2 envelope proteins The invention relates to the generation and the use of pestivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto retroviral core particles. These particles are highly infectious and constitute a valid model of pestivirus virion. ... 03/29/07 - 20070072190 - System and method for universal identification of biological humans A system and method for uniquely identifying each human being and generate a Universal Identification Number (UIN) to aid tracking. UIN database comprises of public, health, and confidential information. The number issued for display on UIN Identity Card and used for accessing data on-line protects privacy of the individual by ... 03/29/07 - 20070072189 - Artificial mutation controls for diagnostic testing Disclosed are artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular mutation. Also provided are methods of generating such compositions, and ... 03/29/07 - 20070072188 - Methods for detection of mycobacterium tuberculosis The present invention provides an oligonucleotide primer pair having SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of Early Secretory Antigenic Target (esat)-6-gene of Mycobacterium species. The invention also provides a method for detecting M .tuberculosis in a sample based on the amplification of esat-6 gene, comprising ... 03/29/07 - 20070072187 - Novel methods and apparatus for cell based microarray assays The present invention relates methods for screening of cellular responses comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels (b) providing cellular components on said first and/or second surface of said solid porous support, wherein said ... 03/29/07 - 20070072186 - Methods and agents for screening for compounds capable of modulating her2 expression The invention relates to the fields of screening assays and compounds and methods for altering protein expression and levels of protein. In particular, the invention includes assays to screen for agents capable of modulating expression of Her2 and agents capable of modulating Her2 expression. ... 03/29/07 - 20070072185 - Carbohydrate-binding modules of a new family The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member ... 03/29/07 - 20070072184 - Susceptibility gene for alzheimer's disease The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene. ... 03/29/07 - 20070072183 - Topoisomerase hybrids and methods of use The present invention provides hybrid topoisomerases, methods for assaying topoisomerase activity, methods for identifying compounds that modulate topoisomerase activity, and methods for identifying antibacterial agents. ... 03/29/07 - 20070072182 - Methods for amplification of nucleic acid sequences using staggered ligation Methods and kits are provided for producing sense RNA molecules. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 03/29/07 - 20070072181 - Combination therapy for treating alphavirus infection and liver fibrosis The present invention provides methods for treating alphavirus infections; methods of treating hepatitis C virus (HCV) infections; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with ... 03/29/07 - 20070072180 - Mutations in nod2 are associated with fibrostenosing disease in patients with crohn's disease The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of ... 03/29/07 - 20070072179 - Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures The present invention relates to a method and kit for analyzing complex mixtures of biopolymers from one or more samples. ... 03/29/07 - 20070072178 - Novel genetic markers for leukemias The present invention is related to methods for detecting leukemia cells by determining the expression profile of a group of markers. In particular, the type or subtype of leukemia cells in a sample is determined. Further, uses of the group of markers is discloses and compositions comprising these markers. ... 03/22/07 - 20070065876 - Marking The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of ... 03/22/07 - 20070065875 - Ntb-a, a surface molecule involved in natural killer cells activity The present invention relates to a novel protein, termed NTB-A, nucleic acid molecules encoding the same and uses thereof. The invention also relates to methods of regulating Natural Killer cells activity by regulating the activity of NTB-A in vitro, ex vivo or in vivo. The invention also comprises methods of ... 03/22/07 - 20070065874 - Compositions and methods comprising control nucleic acid The present invention relates, in part, to control nucleic acid molecules having no significant sequence homology to any known nucleic acid, and predefined G/C-content. The present invention further relates to method of using control nucleic acid molecules to validate microarray analyses, compositions comprising control nucleic acid molecules, and kits comprising ... 03/22/07 - 20070065873 - Human t2r55 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R55 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065872 - Apparatus and methods for detecting dna in biological samples Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a ... 03/22/07 - 20070065871 - Human t2r71 receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R71 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065870 - Human t2r67 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065869 - Methods for producing ligand arrays Methods for producing ligand arrays, e.g., peptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same are provided. In one embodiment of the subject methods, a substrate having a surface displaying acetate functional groups that produce ... 03/22/07 - 20070065868 - Il-17 receptor like molecules and uses thereof Novel IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 ... 03/22/07 - 20070065867 - Promoter and plasmid system for genetic engineering This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful ... 03/22/07 - 20070065866 - Compositions and methods for suppressing fibrocytes The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, ... 03/22/07 - 20070065865 - Polymorphisms associated with coronary artery disease The invention provides human polymorphisms that are associated with coronary artery disease (CAD). Polymorphisms in genes were identified that confer an increased susceptibility to CAD or a decreased susceptibility. Particular alleles of the polymorphisms were identified as being associated with differential risk. In particular an allele of CDC42 in combination ... 03/22/07 - 20070065864 - Message abundance and allele copy number determination using ivt with single-stranded primer-promoter-selector constructs Disclosed is a single stranded primer-promoter-selector construct comprising (in 3′ to 5′ orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide. ... 03/22/07 - 20070065863 - Method for detecting a risk of cardiovascular disease Single nucleotide polymorphisms associated with serum C-reactive protein levels are disclosed. Also disclosed are methods of using these markers to predict the propensity for cardiovascular diseases and the time to first myocardial infarction. ... 03/22/07 - 20070065862 - Methods for analysis of genetic interactions The present invention provides an isolated interaction polynucleotide that contains a tag sequence and two or more genetic elements. The present invention also provides a method for identifying an interaction between two or more genetic elements. One embodiment of the present invention provides a method for analyzing and identifying the ... 03/22/07 - 20070065861 - Methods for genetic analysis of alternative splicing The present invention provides methods for large-scale functional analysis of splicing variants. Specifically, the present methods provide polynucleotide probes that incorporate exon junction sequences arising from alternative splicing events. In one embodiment of this invention, the function of a splice variant is determined by identifying a polynucleotide comprising an exon ... 03/22/07 - 20070065860 - Accelerated class i and class ii hla dna sequence-based typing There is provided a method for directly typing or sequencing HLA class I or class II alleles from a tissue sample wherein at least one exon of the HLA class I or class II alleles from the sample is amplified in a locus specific manner utilizing two primers, wherein at ... 03/22/07 - 20070065859 - Methods and materials for identifying the origin of a carcinoma of unknown primary origin The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and ... 03/22/07 - 20070065858 - Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an ... 03/22/07 - 20070065857 - Optical system for plant characterization A system is provided to monitor targeted pest populations, disease, presence of transgenic and non-transgenic plants, or targeted pest population in a transgenic crop using remote imagery to discern differences in crops along with pest infestation in all crop varieties. The system relies on the fact that plant leaves are ... 03/22/07 - 20070065856 - Molecular method for diagnosis of prostate cancer Methods for diagnosing or detecting cancerous prostate tissue. A panel of 8 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal prostate tissue and the underexpression of the rest of these marker genes are indicative of cancerous prostate tissue. By ... 03/22/07 - 20070065855 - Biochip and analytical instrument for analyzing same There is provided a biochip capable of quantitatively grasping hybridization efficiency. In the biochip comprising a plurality of probe sites with target molecules bonded thereto, respectively, the probe sites disposed thereon, the marker sites with a known number of fluorescent molecules bonded thereto, respectively, are disposed. With the biochip, the ... 03/22/07 - 20070065854 - Serum-free medium for producing retroviruses A method for obtaining a virus vector free of a serum, and a serum-free medium for cultivation of a virus producer cell which can be used for the method are provided. By cultivating a virus producer cell using a serum-free medium containing serum albumin, it is possible to cultivate the ... 03/22/07 - 20070065853 - Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy The present invention deals with a method of preparing nucleic acids, particularly RNA, from a whole blood sample. The nucleic acids purified by the method of the invention are particularly suited for detection of nucleic acid marker molecules. Preferred are markers for the diagnosis of transmissible spongiform encephalopathy (TSE). Such ... 03/22/07 - 20070065852 - Hiv recombinant vaccine Reagents and methods for making and using HIV recombinant vaccines are disclosed. ... 03/22/07 - 20070065851 - Method for detecting a microorganism in a fecal specimen The invention relates to detecting microorganisms in specimens for the purposes of inter alia diagnoses, screenings, quarantine inspections, and clinical tests. Specifically, it relates to detecting and quantifying enteropathogenic bacteria in a fecal specimen, including Shigella species, Salmonella species, Campylobacter species, enterohemorrhagic E. coli or Verocytotoxin-producing E. coli, Vibrio cholerae, ... 03/22/07 - 20070065850 - Method for diagnosis of heart failure A method for diagnosis of heart failure in a human subject, which comprises the step of: measuring an endoplasmic reticulum (ER)-initiated apoptotic signal such as CHOP in a biological sample originated from the subject is disclosed. According to the invention, by employing the new marker in stead of or in ... 03/22/07 - 20070065849 - Nucleic acid encoding eosinophil eotaxin receptor The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human β-chemokine receptor and has been designated “CC CKR3”. The eosinophil eotaxin receptor may be used to screen and identify compounds that bind to the eosinophil eotaxin receptor. Such compounds would be useful in the treatment ... 03/22/07 - 20070065848 - 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, ... 03/22/07 - 20070065847 - Degeneratively labeled probes The invention is directed to methods for determining whether any of group of analytes of interest are present in a sample, and optionally, in at least one subsequent determination, which of the analytes are present. The invention is also directed towards methods for the rapid and efficient determination of the ... 03/22/07 - 20070065846 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/22/07 - 20070065845 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/22/07 - 20070065844 - Solution-based methods for rna expression profiling The present invention is directed to novel high-throughput, low-cost, and flexible solution-based methods for RNA expression profiling, including expression of microRNAs and mRNAs. ... 03/22/07 - 20070065843 - Polymorphisms in mitochondrial transcription factor a (tfam) gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine ... 03/22/07 - 20070065842 - Detection of survivin in the biological fluids of cancer patients The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing. ... 03/22/07 - 20070065841 - Methods and compositions for the removal of nucleic acid amplification inhibitors An improved method for preparing nucleic acid extracts from environmental samples contaminated by polymerase inhibitors such as humic and fulvic acids is provided. The methods of the invention utilize chemical compositions capable of precipitating humic and/or fulvic acids from organic samples. The methods may be used in connection with the ... 03/22/07 - 20070065840 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single ... 03/22/07 - 20070065839 - Method of identifying agents to prevent or treat diabetes The invention provides an assay for identifying agents that can prevent and treat diabetes. Specifically, the assay is a novel tool for identifying agents that can up regulate cholecystokinin (CCK) expression in pancreatic islets of mammals. The increased expression of CCK triggers an increase in pancreatic β-cell mass and plasma ... 03/22/07 - 20070065838 - Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided. ... 03/22/07 - 20070065837 - Methods and compositions for the detection of chlamydia trachomatis The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid ... 03/22/07 - 20070065836 - Chromosome 1p36 polymorphisms and low bone mineral density The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353. ... 03/22/07 - 20070065835 - Dna fingerprinting using a branch migration assay A method of determining the length of a polynucleotide target is provided. With this method, a target is first hybridized to an array of first probes having different, determined lengths, resulting in the formation of duplexes between the polynucleotide target and the first probes. These duplexes have a single stranded ... 03/22/07 - 20070065834 - Method and sequences for determinate nucleic acid hybridization Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be ... 03/22/07 - 20070065833 - Method of detecting thyroid cancer A method of detecting thyroid cancer in a subject includes obtaining a nucleic acid sample from a bodily sample of the subject and determining whether the nucleic acid sample contains at least one of thyroid stimulating hormone receptor (TSHR) mRNA or thyroglobulin (Tg) mRNA. ... 03/22/07 - 20070065832 - Computer-implemented biological sequence identifier system and method A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search. ... 03/22/07 - 20070065831 - Function and regulation of adamts-1 The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to the function of ADAMTS-1. ... 03/22/07 - 20070065830 - Cloning multiple control sequences into chromosomes or into artificial centromeres Artificially synthesizing 29 homozygous cystic fibrosis core panel controls demonstrates placing multiple homozygous mutant sequences on the same single control DNA sequence to streamline quality control by minimizing extra control assays, time, and costly formatted test materials and testing all controls during every test. Any rare or unavailable reported DNA ... 03/22/07 - 20070065829 - In vitro differentiation of vascular smooth muscle cells, methods and reagents related thereto This invention is directed to an in vitro system for rapidly and uniformly inducing immortalized neural crest cells to differentiate to vascular smooth muscle cells. As excessive proliferation of vascular smooth muscle cells is a phenotypic response to the development of occlusive arteriosclerotic disease, the in vitro system of this ... 03/22/07 - 20070065828 - Oligonucleotide for genotyping of mycoplasma, microarray comprising the oligonucleotide, and method for detection of species using the microarray As described above, the present invention provides a rapid and accurate assay method capable of simultaneously detecting many Mycoplasma and its related strains from a single sample using a microarray comprising novel oligonucleotides for detecting Mycoplasma and its related strains which are known as a source of contamination of cell ... 03/22/07 - 20070065827 - Gene expression profiles and methods of use The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides ... 03/22/07 - 20070065826 - Cationic dye compound for detecting nucleic acid double strand, and detection method and apparatus using same A cationic dye compound having novel uses, the cationic dye compound being capable of conveniently and rapidly detecting a nucleic acid double strand, and a detection method using the cationic dye compound are provided. This invention relates to a cationic dye compound for detecting a nucleic acid double strand, comprising: ... 03/22/07 - 20070065825 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity. ... 03/22/07 - 20070065824 - Method for the detection of cytosine methylations in dna by means of cytidine deaminases The present invention concerns a method for investigating cytosine methylations in DNA sequences. By this means, the DNA to be investigated is reacted with a cytidine deaminase which deaminates cytidine more rapidly than 5-methylcytidine. Cytosine is converted to uracil by the conversion, whereas 5-methylcytosine remains essentially unchanged. The enzymatically pretreated ... 03/22/07 - 20070065823 - Method and compositions for detection and enumeration of genetic variations Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to ... 03/22/07 - 20070065822 - Substrates for spatially selective micron and nanometer scale deposition and combinatorial modification and fabrication A substrate (1) for spatially selective micron and nanometer scale deposition and/or reaction, which has a support (3), a conductive layer (5) on the support, a dielectric layer (7) to hold an electrostatic charge pattern such as a photoconductive layer of a material which dissipates an electric charge upon receiving ... 03/22/07 - 20070065821 - Methods for the prediction of suicidality during treatment This invention provides methods to predict the likelihood of suicidal or self-destructive behavior in a patient during treatment. The method employs the detection of a polymorphism in the SLC6A3 gene at Exon 9 A59G or a surrogate marker, by various methods. Also provided are methods of treatment based on the ... 03/22/07 - 20070065820 - Lipid-associated molecules Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM. ... 03/22/07 - 20070065819 - Novel fprl1 ligands and use thereof By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed. ... 03/22/07 - 20070065818 - Photoprotein with improved bioluminescence Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium. ... 03/22/07 - 20070065817 - Nucleic acid probes for detection of non-viral organisms The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more ... 03/22/07 - 20070065816 - Methods for genotyping Novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample are provided. A reduced complexity sample is generated and then analyzed. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further ... 03/15/07 - 20070059760 - Multi-featured arrays with reflective coating A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously ... 03/15/07 - 20070059759 - Human t2r63 receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R63 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070059758 - Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF ... 03/15/07 - 20070059757 - Method and compositions for the treating diseases targeting e-cadherin Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro. ... 03/15/07 - 20070059756 - Immunointeractive molecules and their uses in treating subjects suffering from hev b 5 allergies The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having latex allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Hev b 5 allergy. The present invention also extends ... 03/15/07 - 20070059755 - Methods for selective targeting A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound ... 03/15/07 - 20070059754 - Systems and methods for fluorescence detection with a movable detection module A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module ... 03/15/07 - 20070059753 - Detecting gene methylation Methods, kits, and compositions for detecting the methylation status of various genes are useful in various diagnostic applications involving suspected proliferative disorders such as prostate cancer. ... 03/15/07 - 20070059752 - Fluorescence energy transfer probes with stabilized conformations The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties. ... 03/15/07 - 20070059751 - Nucleic acid isolation method In a nucleic acid isolation method for a solid biological sample, since two or more kinds of instruments are used for biological sample disruption and nucleic acid isolation, the operations are complicated, thereby increasing the operating labor, prolonging the operation time, and deteriorating the property of a nucleic acid associated ... 03/15/07 - 20070059750 - Identifier and nucleic acid amplification method of verification using the same There is provided an identification technique that can consistently maintain a set of information specifying a specimen through all the processes from the amplification process to the detection process of a specific sequence. A base sequence incorporating as a set of decodable information an individual code imparted to the specimen ... 03/15/07 - 20070059749 - Nucleic acid, nucleic acid for detecting chlorinated ethylene-decomposing bacteria, probe, method of detecting chlorinated ethylene-decomposing bacteria, and method of decomposing chlorinated ethylene Chlorinated ethylene-decomposition bacteria is detected by performing PCR using nucleic acid comprising 18˜25 nucleotides that preferentially hybridizes to the 16S rRNA or rDNA of chlorinated ethylene-decomposing bacteria and has any of base sequences of SEQ ID No. 1˜15, a base sequence that has at least 90% homology with any of ... 03/15/07 - 20070059748 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers. ... 03/15/07 - 20070059747 - Methods and probe combinations for detecting melanoma The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells. ... 03/15/07 - 20070059746 - Substance carrier using hollow nanoparticle of hepatitis b virus protein and liposome, and method of introducing substance into cell The present invention relates to a method of producing a composite particle of a nanoparticle and a liposome in which a substance to be introduced has been encapsulated, characterized in that a hollow nanoparticle containing a hepatitis B virus protein or a modification thereof is fused to the liposome in ... 03/15/07 - 20070059745 - Blood assessment of injury Methods of injury assessment in an individual include the steps of determining a pattern of expression exhibited by blood cells obtained from an individual and comparing the pattern of expression exhibited by the obtained blood cells to an injury database to assess the injury. ... 03/15/07 - 20070059744 - Corynebacterium glutamicum genes encoding novel proteins Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 03/15/07 - 20070059743 - Method for the design of oligonucleotides for molecular biology techniques The present invention discloses a method that can be used to identify one DNA sequence or one specific group of DNA sequences from a complex biological sample. Diverse molecular biology methods require the use of short DNA sequences, called oligonucleotides, that are artificially synthesized from a description of their composing ... 03/15/07 - 20070059742 - Process of stripping a microarray for reuse Disclosed herein is a process for stripping oligonucleotide target from a microarray to allow reuse of the microarray. The process comprises providing a microarray having probe oligonucleotides attached thereto and target oligonucleotides hybridized to the probe oligonucleotides. The microarray is then incubated with a formulation comprising an organic solvent and ... 03/15/07 - 20070059741 - Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid With an insulated gate field effect transistor in which deoxyribonucleic acid (DNA) probes are immobilized on a gold electrode, extension reaction on the gold electrode is performed with DNA polymerase to directly measure an increased amount of a phosphate group caused by the extension reaction, that is, negative charge, by ... 03/15/07 - 20070059740 - Method of targeting a2b adenosine receptor antagonist therapy Provided herein are methods for determining if a subject will benefit from A2B receptor antagonist therapy. ... 03/15/07 - 20070059739 - Pure mirna sample preparation method The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example, ... 03/15/07 - 20070059738 - Diagnosis and treatment of hepatic disorders The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving α4β7/MAdCAM ... 03/15/07 - 20070059737 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/15/07 - 20070059736 - Bio-analysis chip, bio-analysis system and bio-analysis method A bio-analysis chip which is convenient in use and can promptly detect microbes with high accuracy. The bio-analysis chip comprises a collection member for collecting microbes in the atmosphere with the microbes adhering to the collection member, and a substrate in the form of a thin plate on which the ... 03/15/07 - 20070059735 - Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample The present invention relates to oligonucleotides useful for determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, capture probes and amplification oligonucleotides, and used in various combinations thereof. ... 03/15/07 - 20070059734 - Reagent for detecting biopolymer and method for detecting biopolymer Detects the presence of binding between a sample biopolymer and a probe biopolymer and the amount of binding, without modifying the sample biopolymer in any way. The present invention provides a reagent for biopolymer detection comprising semiconductor nanoparticles on which a functional group having a positive or negative charge is ... 03/15/07 - 20070059733 - Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups The present methods and apparatus concern nucleic acid sequencing by incorporation of nucleotides into nucleic acid strands. The incorporation of nucleotides is detected by changes in the mass and/or surface stress of the structure. In some embodiments of the invention, the structure comprises one or more nanoscale or microscale cantilevers. ... 03/15/07 - 20070059732 - Detection of target analytes using particles and electrodes The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte ... 03/15/07 - 20070059731 - Ubiquitin mediated fluorescence complementation assay The present invention relates to methods and compositions for identifying covalent joining or modification of proteins. In particular, the present invention relates to covalent fluorescence complementation assays for the detection of modified (e.g., ubiquitinated proteins). The present invention further relates to the use of such fluorescence complementation assays in drug ... 03/15/07 - 20070059730 - Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic ... 03/15/07 - 20070059729 - Nucleic acids and corresponding proteins entitled 282p1g3 useful in treatment and detection of cancer A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or ... 03/15/07 - 20070059728 - Computer-implemented biological sequence identifier system and method A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained ... 03/15/07 - 20070059727 - Directional self-assembly of biological electrical interconnects Microtubules are excellent candidates for the fabrication of nanostructures, including nanowires. A method for controlled nucleation and growth of microtubules on substrates (e.g., gold on a silicon wafer) is provided. The substrate is functionalized with a nucleating agent for microtubule growth. The method can be employed to generate nanoscale structures ... 03/15/07 - 20070059726 - Differential transcript expression Multiple transcripts from the same gene maybe differentially regulated. Finding such differential regulation under distinct physiological conditions implicates the gene in the generation or response to the physiological condition. Transcripts have been identified from five genes which appear to be differentially regulated in lung cancer and normal cells. We have ... 03/15/07 - 20070059725 - Apparatus and method for detecting microscopic organisms using bacteriophage Methods and apparatus are provided for detection of microorganisms in a sample. Methods and apparatus of the invention are based on the specificity that phage, for example bacteriophage, have for target microorganisms, for example bacterium. Typically, phage adsorption to target microorganisms act as signal, or a signal target, for the ... 03/15/07 - 20070059724 - Novel compositions and methods for lymphoma and leukemia The present invention relates to novel sequences for use in diagnosis and treatment of lymphoma and leukemia. In addition, the present invention describes the use of novel compositions for use in screening methods. ... 03/15/07 - 20070059723 - Secreted epithelial colon stromal-1 molecules and uses thereof The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing Secs-1 polypeptides. The invention further provides methods for the treatment, diagnosis, amelioration, or prevention of diseases associated with ... 03/15/07 - 20070059722 - Novel genes and markers associated to type 2 diabetes mellitus Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D using polymorphisms in the T2D risk genes are also disclosed. The genes, gene products and agents of the invention are ... 03/15/07 - 20070059721 - Magi polynucleotides, polypeptides, and antibodies MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays. ... 03/15/07 - 20070059720 - Rna expression profile predicting response to tamoxifen in breast cancer patients The present invention regards predicting a response to a therapy using RNA expression profiling. In particular, a resistance to a chemotherapy, such as tamoxifen, is predicted by comparing expressed genes in a patient on the therapy to a patient sensitive to the chemotherapy. In further embodiments, there is an RNA ... 03/15/07 - 20070059719 - Business methods for prenatal diagnosis The present invention relates to business methods in which screening services and diagnostics for the condition of a fetus are provided. Fetal abnormalities, include chromosomal and other genetic ies, are detected through the analysis of fetal cells obtained from maternal blood samples. ... 03/15/07 - 20070059718 - Systems and methods for enrichment of analytes The present invention relates to methods for detecting and concentrating minute amounts of biohazard analytes, including but not limited to bacteria, protozoa, viral pathogens, and toxins, in environmental and other samples. These analytes can be substantially enriched by the methods of the invention, and further, a second analyte can be ... 03/15/07 - 20070059717 - Systemic lupus erythematosus diagnostic assay The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile ... 03/15/07 - 20070059716 - Methods for detecting fetal abnormality The invention relates to a method of identifying fetal abnormality from a maternal blood sample by capturing an image of a fetal nucleated red blood cell obtained from the maternal blood sample; inputting probe intensities for a plurality of nucleic acid probes that bind fetal nucleic acids of interest; analyzing ... 03/15/07 - 20070059715 - Quantitative gene expression profiling Described herein are approaches to the measurement of gene expression for chosen genes in a biological sample. The methods permit the quantitation of target nucleic acids, e.g., DNAs or RNAs in a nucleic acid sample, both singly and in a multiplex format that permits the determination of levels (e.g., expression ... 03/15/07 - 20070059714 - Detection of presence and antibiotic susceptibility of enterococci The present invention relates in general to the detection of antibiotic resistance genes in Enterococci. The present invention discloses a micro-array for the detection of the presence of bacteria of the genus Enterococcus and antibiotic resistance genes in said organism, a method for the detection of said genes and a ... 03/15/07 - 20070059713 - Ssb-dna polymerase fusion proteins Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR). ... 03/15/07 - 20070059712 - Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein ... 03/15/07 - 20070059711 - Microarray for evaluation of stress-related genes in skin The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 ... 03/15/07 - 20070059710 - Genetic polymorphisms associated with stroke, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, ... 03/15/07 - 20070059709 - Staphylococcus aureus antibacterial target genes This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are ... 03/15/07 - 20070059708 - Gene screen We describe a method for the identification of genes which show regulated expression in response to carbon source utilisation, typically genes associated with the initiation and/or promotion of cell transformation from a non-cancerous to a cancerous phenotype, typically of cells found in the colon; the use of these genes in ... 03/15/07 - 20070059707 - Methods for prenatal diagnosis of chromosomal abnormalities Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus, ... 03/15/07 - 20070059706 - Materials and methods relating to breast cancer classification The inventors set out to identify a set of genes for use as prognostic markers for breast tumours which correlate with the Nottingham Prognostic Index (NPI). Initially they were unable to identify a single set of genes whose expression correlates with the NPI. However after segregating the dataset into molecular ... 03/15/07 - 20070059705 - Fluorescent magnetic nanoparticles and process of preparation This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be ... 03/15/07 - 20070059704 - Detection system The invention provides a methods and materials for detecting an activity of a glycopeptide antibiotic (such as a vancomycin-type antibiotic), in a sample, the method comprising the steps of: (a) providing a microorganism in which a first endogenous gene encoding peptidyltransferase activity is inactivated, which activity is necessary for growth ... 03/15/07 - 20070059703 - Genome mapping of functional dna elements and cellular proteins The disclosure provides methods of examining the binding of proteins to DNA across a genome (e.g., the entire genome or a portion thereof, such as one or more chromosomes or a chromosome regions). In particular, the disclosure relates to a method of identifying a regulatory region (e.g., a protein or ... 03/15/07 - 20070059702 - Disease related protein network The present invention relates to a method for generating a network of direct and indirect interaction partners of a disease-related (poly)peptide comprising the steps of (a) contacting a selection of (poly)peptides suspected to contain one or several of said direct or indirect interaction partners with said disease-related (poly)peptides and optionally ... 03/15/07 - 20070059701 - Fluorescence assays for nucleic acid polymerase activity The present invention provides methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity. ... 03/15/07 - 20070059700 - Methods and compositions for optimizing multiplex pcr primers This invention relates generally to the field of PCR. In particular, the invention provides methods, compositions and kits for optimizing multiplex PCR primers using, inter alia, a plurality of 5′ and 3′ specific primers and a 5′ and a 3′ universal primer at various ratios. ... 03/15/07 - 20070059699 - Methods for detecting toxic and non-toxic cyanobacteria This invention is related to a method for detecting toxic and non-toxic cyanobacteria. The method comprises that nucleic acid from a biological sample is brought into contact with an oligonucleotide designed to be specific for the mcy gene, in particular mcyE and/or mcyD, and with an oligonucleotide designed to be ... 03/15/07 - 20070059698 - Marks as modifers of the pten pathway and methods of use Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that ... 03/15/07 - 20070059697 - Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, ... 03/15/07 - 20070059696 - Assessment method The present invention relates generally to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response in a mammal. More particularly, the present invention relates to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response by analysing one or ... 03/15/07 - 20070059695 - Sgk1 as diagnostic and therapeutic target The invention relates to the utilization of a substance for diagnostic determination of sgk1 (serum and glucocorticoid dependent kinase 1) and to the utilization of an active agent in order to influence sgk1 for therapeutic treatment of diseases associated with disordered activity of the tissue factor and to a diagnostic ... 03/15/07 - 20070059694 - Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep1 (prostaglandin e2 ep1) The invention provides a human prostaglandin E2 EP1 which is associated with the cardiovascular diseases, respiratory diseases, hematological diseases, urological diseases, gastrointestinal diseases, endocrinological diseases and metabolic diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, hematological ... 03/15/07 - 20070059693 - Hybridization-based biosensor containing hairpin probes and use thereof A sensor chip that includes: a fluorescence quenching surface; a nucleic acid probe that contains first and second ends with the first end bound to the fluorescence quenching surface, a first region, and a second region complementary to the first region, the nucleic acid probe having, under appropriate conditions, either ... 03/15/07 - 20070059692 - Array oligomer synthesis and use The present disclosure provides efficient and reproducible methods for individually synthesizing oligomers in a parallel manner (e.g., oligonucleotides) on a solid support to produce pools of oligomers. Pools of oligonucleotides can be used for a variety of genomic and proteomic applications, including synthesis of genes or long DNA of any ... 03/15/07 - 20070059691 - Method for determining the susceptibility of a subject to infection A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii) optionally comparing the level of LL-37 in said sample to a control sample; and (iv) determining the susceptibility of said ... 03/15/07 - 20070059690 - met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands Disclosure of a method for the detection and quantitation of polynucleotide sequences in a sample of biological or non-biological material through target poly nucleotide sequence amplification by polymerase chain reaction using chemically labeled oligonucleotide amplification primers and formation of an entity between the amplified polynucleotide sequence and chemically labeled polynucleotide ... 03/15/07 - 20070059689 - Hybrid glycosylated products and their production and use Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also produces or is supplied with an aglycone template. At least some of the components ... 03/15/07 - 20070059688 - Gastrointestinal chemosensory receptors This invention provides isolated nucleic acid and amino acid sequences of gastrointestinal endocrine cell specific G-protein coupled receptors, methods of detecting such receptors, and methods of screening for ligands of such receptors. Furthermore, this invention demonstrates that SrC-1 enteroendocrine cells express multiple bitter taste receptors as well as a-subunits of ... 03/15/07 - 20070059687 - Process for evaluating phagocytotic function and use thereof A digested phagocyte prepared by contacting in vitro a phagocyte with a foreign microorganism and isolating the phagocyte so contacted; a process for producing the same; and a process and a kit in which these are utilized are disclosed. An experimental model, which enables in vitro evaluation of a phagocytotic ... 03/08/07 - 20070054314 - Adiponectin receptor and gene encoding the same The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is ... 03/08/07 - 20070054313 - Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided. ... 03/08/07 - 20070054312 - Human transmembrane proteins The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN. ... 03/08/07 - 20070054311 - Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library ... 03/08/07 - 20070054310 - Novel polypeptide, cdna encoding the same, and use thereof Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or ... 03/08/07 - 20070054309 - Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific ... 03/08/07 - 20070054308 - Fluorescence polarization assay The present invention relates to methods for detecting the presence of one or more analytes of interest in a sample by measuring changes in fluorescence anisotropy as a result of binding of the analytes to specific aptamers. The aptamers are immobilized on a solid support and may be in the ... 03/08/07 - 20070054307 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of ... 03/08/07 - 20070054306 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/08/07 - 20070054305 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/08/07 - 20070054304 - Compositions and methods for detection and isolation of phosphorylated molecules The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and ... 03/08/07 - 20070054303 - Expression vectors and methods Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage. ... 03/08/07 - 20070054302 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of ... 03/08/07 - 20070054301 - Methods, compositions and kits for isothermal amplification of nucleic acids Methods and compositions are described for isothermal nucleic acid amplification of a nucleic acid template strand by using an oligonucleotide primer that includes an AT-rich nucleotide sequence and a polymerase having strand displacement activity. ... 03/08/07 - 20070054300 - Method for the identification and quantification of microorganisms useful in biomining processes The method comprises performing a two-stage PCR known as nested PCR, where in the first stage, called primary PCR, 16S ribosomal DNA sequences (nucleotides 27 to 1492, with E. coli rDNA numbering) are amplified using universal primers for the Bacteria and Archaea kingdoms. In the second stage, these primary amplicons ... 03/08/07 - 20070054299 - Apparatus for active programmable matrix devices A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. Preferably, a fluidic system flow a sample across an active area of the biochip, increasing diagnostic efficiency. Preferably, the fluidic system includes ... 03/08/07 - 20070054298 - Methods for enzyme-mediated coupling of oligomers The present invention is directed to a method for synthesizing sequence specific short and long chain length heteropolymers. More specifically, the method is directed to enzyme-mediated ligation of telechelic sequence specific oligomers to generate abiotic linked oligomers and concatenated synthetic oligomers. The invention also encompasses abiotic linked oligomers and abiotic ... 03/08/07 - 20070054297 - Mammalian relaxin receptors High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are orphan leucine-repeat-containing, G protein-coupled receptors. These receptors have a wide and a unique tissue expression pattern. The receptors, particularly soluble fragments thereof, are useful ... 03/08/07 - 20070054296 - Methods for multiplexing recombinase polymerase amplification This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. ... 03/08/07 - 20070054295 - Gc tag-modified bisulfite genomic dna sequencing for continuous methylation spectra The present invention relates to a tag-modified bisulfite genomic sequencing (tBGS) method developed for simplified evaluation of DNA methylation sites. The method employs direct cycle sequencing of PCR products at kilobase scale, without conventional DNA fragment cloning. The method entails subjecting bisulfite-modified genomic DNA to a second-round PCR amplification employing ... 03/08/07 - 20070054294 - Cotton event pv-ghgt07(1445) and compositions and methods for detection thereof The present invention provides DNA compositions and assays for detecting the presence of the DNA compositions in PV-GHGT07(1445) cotton event based on the DNA sequence of the recombinant construct inserted into the cotton genome and of the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the ... 03/08/07 - 20070054293 - Microfluidic chaotic mixing systems and methods Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump ... 03/08/07 - 20070054292 - Bacteriophage linked immunosorbent assay for rapid, sensitive detection of multiple analytes The invention is a method for the development of a platform that enables the efficient and simultaneous creation of multiple detection assays. The invention entails the use of any bacteriophage, modified to carry a reporter gene, to which any analyte-recognizing moiety is attached via the capsid. The modified bacteriophage is ... 03/08/07 - 20070054291 - System for detection of nucleic acids System, including methods, apparatus, and kits, for detection of nucleic acids. ... 03/08/07 - 20070054290 - Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of ... 03/08/07 - 20070054289 - Identification of genes involved in fertility, ovarian function and/or fetal/newborn viability A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, ... 03/08/07 - 20070054288 - Programmable molecular barcodes The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind ... 03/08/07 - 20070054287 - Method for identifying medically important cell populations using micro rna as tissue specific biomarkers The present teachings provide methods for diagnosing biological conditions, including cancer. In some embodiments, a test sample is collected from a subject such as a clinical patient, wherein the test sample comprises background tissue and may or may not contain cells from a tissue of interest. Observation of a target ... 03/08/07 - 20070054286 - Arrays of nucleic acid probes for analyzing biotransformation genes The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three ... 03/08/07 - 20070054285 - Method for isolating nucleic acids Described herein is a method in which genomic nucleic acid of a cell can be separated from nucleic acid having a molecular weight that is lower than the molecular weight of the genomic nucleic acid (e.g., plasmid DNA) of the cell directly from a cell growth culture. Also described herein, ... 03/08/07 - 20070054284 - Nucleic acid and corresponding protein entitled 184p1e2 useful in treatment and detection of cancer A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene ... 03/08/07 - 20070054283 - Dna sequencing method using step by step reaction The present invention provides an inexpensive DNA sequencing method with high-sensitivity. The method of the present invention comprising the steps of, adding an given amount of dATP for step by step complementary strand synthesis and subtracting the background luminescence intensity caused by dATP from the measured luminescence intensity to obtain ... 03/08/07 - 20070054282 - Method for the detection of gene transcripts in blood and uses thereof The present invention relates generally to the identification of biomarkers of conditions including disease and non disease conditions as well as identifying compositions of biomarkers. The invention further provides a method of diagnosing disease, monitoring disease progression, and differentially diagnosing disease. The invention further provides for kits useful in diagnosing, ... 03/08/07 - 20070054281 - Compositions and methods relating to osteoarthritis Described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having osteoarthritis. Also described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having a particular stage of ... 03/08/07 - 20070054280 - High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics An optical micro-array reader system includes microchip, VCSEL, microlens and detector arrays. The microchip array includes multiple sample spots to be separately analyzed. The VCSEL array is disposed to simultaneously illuminate more than one of the multiple spots. The microlens array focuses fluorescences or other optical emissions from the sample ... 03/08/07 - 20070054279 - Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one ... 03/08/07 - 20070054278 - Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof The present invention is based on the discovery of polymorphisms in enzyme genes and encoded enzyme protein variants. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and ... 03/08/07 - 20070054277 - Computer-directed assembly of a polynucleotide encoding a target polypeptide The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding ... 03/08/07 - 20070054276 - Polynucleotide analysis and methods of using nanopores Polynucleotide analysis systems and methods of nanopore analysis are provided. ... 03/08/07 - 20070054275 - Method evolved for recognition of thrombophilia (mert) Methods for predicting an individual's genetic risk for developing venous thrombosis in diverse ethnic populations is disclosed, as are arrays and kits which can be used to practice the method. The method includes screening for mutations, polymorphisms, or both, in at least eight venous thrombosis-related molecules, such as antithrombin III, ... 03/08/07 - 20070054274 - Gene modulation by rb2/p130 expression The present invention discloses a set of molecular signatures modulated by RB2/p130 for lung cancer cells and a method of determining whether to use a RB2/p130 gene expression system or a protein encoded by the system to modulate a gene or gene expression pattern in lung cancer cells of mammals. ... 03/08/07 - 20070054273 - Microarray devices having controllable reaction volume This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction, ... 03/08/07 - 20070054272 - Method of preparing dna fragments by selective fragmentation of nucleic acids and applications thereof The invention relates to a method of preparing DNA fragments by selective fragmentation of nucleic acid fragments. The inventive method comprises a first selection step involving selection of short fragments, consisting in: a) preparing first double-stranded DNA fragments F1 using at least one restriction enzyme E1 which can randomly fragment ... 03/08/07 - 20070054271 - Gene expression in breast cancer The invention features nucleic acids encoding proteins that are expressed at a higher or a lower level in breast cancer cells than in normal breast cells or in a cell of one grade or stage of breast cancer than in a cell of another grade or stage of breast cancer. ... 03/08/07 - 20070054270 - Preloaded microfluidic devices A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a ... 03/08/07 - 20070054269 - Molecular cardiotoxicology modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of ... 03/08/07 - 20070054268 - Methods of diagnosis and prognosis of ovarian cancer The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expression of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific scanner sub-type. The ovarian cancer-associated genes and ... 03/08/07 - 20070054267 - Primer and probe for detecting vibrio vulnificus and detection method using the same To produce a high-performance specific gene amplification primer for detecting, quantifying, or identifying Vibrio vulnificus, having low risk of misidentification and practically sufficient amplification efficiency and amplification specificity. We have determined partial nucleotide sequences of gyrB, rpoD, and recA genes of Vibrio vulnificus and the closely related species, revealed their ... 03/08/07 - 20070054266 - Chemical sensor system A chemical sensor utilizing a chemical receptor (for example, one stimulating the sense of taste or smell) is provided. More specifically speaking, such a receptor is introduced into cells and the cells are immobilized on a support to form a chip. This chip is then employed as a component of ... 03/01/07 - 20070048784 - Novel human hydrolase family members and uses thereof The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and ... 03/01/07 - 20070048783 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/01/07 - 20070048782 - Methods for assessing and treating leukemia Methods for treating leukemia patients include analyzing gene expression profiles of a patient to determine whether the patient is likely to respond to treatment with farnesyl transferase inhibitor (FTI) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes ... 03/01/07 - 20070048781 - Mammalian cytokines; related reagents and methods Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. ... 03/01/07 - 20070048780 - Circovirus sequences associated with piglet weight loss disease (pwd) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a ... 03/01/07 - 20070048779 - Method for detecting target plant genus The method for detecting species in a target plant genus, particularly an allergenic plant genus such as the genus Fagopyrum, can make it possible to detect with high sensitivity, for example, about 1 ppm of the plant(s) in cases where the plant(s) is contained in a food ingredient or food ... 03/01/07 - 20070048778 - Uses of human zven antagonists The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine. ... 03/01/07 - 20070048777 - Method of nucleic acid analysis by optical detection using disk There is provided a method or structure of carrying out optical measurement for the change of the state of the reactive sample solution at two or more measurement points of the channel simultaneously and continuously in a flow system reaction in which the reactive proceeds according to the elapsed time ... 03/01/07 - 20070048776 - Translation enhancer-element dependent vector systems A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods ... 03/01/07 - 20070048775 - Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites. ... 03/01/07 - 20070048774 - Continuous in-vitro evolution Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby ... 03/01/07 - 20070048773 - Detection of polyphosphate using fluorescently labeled polyphosphate acceptor substrates Provided herein are methods and compositions for fluorogenic detection of a polyphosphate released from a nucleoside polyphosphate by the enzymatic action of a nucleic acid polymerase. The methods and compositions are based on the transfer of a free polyphosphate (or polyphosphate labeled with a fluorescence dye) to a polyphosphate acceptor ... 03/01/07 - 20070048772 - Mammalian iap gene family, primers, probes and detection methods Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. ... 03/01/07 - 20070048771 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the ... 03/01/07 - 20070048770 - Reagents and methods for processing biological samples Methods and processing reagents for improving washing and aging a biological sample in an assay are disclosed. The processing reagents comprise an aqueous base reagent and a low vapor pressure composition in sufficient amount to raise the boiling point of the base reagent. The methods comprise applying the base reagent ... 03/01/07 - 20070048769 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to ... 03/01/07 - 20070048768 - Methods for screening for gene specific hybridization polymorphisms (gshps) and their use in genetic mapping and marker development A method for identification of gene specific hybridization polymorphisms (GSHPs) and their use is presented. The method involves the steps of a) global screening for hybridization polymorphisms using microarray; b) enzyme mediated genome complexity reduction; c) enzyme mediated differential signal amplification and noise reduction; d) data extraction and GSHP identification; ... 03/01/07 - 20070048767 - Marker for a psychosis or a mood disorder An association of a genetic marker with psychosis, a mood disorder, or a combination thereof is provided. Polymorphisms in the GRIN2B gene or alteration in the levels of GRIN2B gene products can be used to diagnose or identify a susceptibility to psychosis, a mood disorder, or a combination thereof. In ... 03/01/07 - 20070048765 - Use of genetic information for identity authentication This invention incorporates genetic information about an individual for use in verifying said individual's identity in transactions where improper identity, identity theft or other use of false identifying information creates financial, personal or other risks. The invention utilizes secure methods wherein an individual's genetic identity is stored by an authenticating ... 03/01/07 - 20070048764 - Indicator polynucleotide controls Methods of selecting indicator polynucleotide controls for use, for example, in determining amounts of indicated polynucleotides in a sample are described. Devices that include indicator polynucleotide controls and data representations relevant to them are also described. A storage medium comprising data obtained from a study using a nucleotide array that ... 03/01/07 - 20070048763 - Polymorphism in the macrophage migration inhibitory factor (mif) gene as marker for prostate cancer The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence ... 03/01/07 - 20070048762 - Real-time monitoring of nucleic acid target-identifying signals This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other ... 03/01/07 - 20070048761 - System and method for authenticating multiple components associated with a particular product A method for authenticating a product where the product is composed of a plurality of components is described. The method for authenticating the product comprises providing a liquid compound, e.g. paint, that comprises at least one invisible market, e.g. nucleic acid, in which the compound is associated with a first ... 03/01/07 - 20070048760 - Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated ... 03/01/07 - 20070048759 - Detection of target molecules with labeled nucleic acid detection molecules The invention is directed to a detection molecule for detection of a target molecule. The detection molecule includes a probe specific to the target molecule. One or more multimer nucleic acid molecules are connected to the probe, whereby the multimer is also coupled to at least one detectable label. The ... 03/01/07 - 20070048758 - Improved primer-based amplification methods The present invention provides methods for amplifying a target nucleic acid with greater efficiency and accuracy by using one or more flap primers. ... 03/01/07 - 20070048757 - Methods for characterizing cells using amplified micro rnas The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. In some embodiments, the present teachings provide methods of forming micro RNA signatures from single cells, including stem cells. In some embodiments, the present teachings provide methods for determining the ... 03/01/07 - 20070048756 - Methods for whole genome association studies Methods for determining the genotype of more than 400,000 Single Nucleotide Polymorphisms (SNPs) in samples of genomic DNA are provided. A collection of SNPs that may be interrogated by the methods is disclosed in SEQ ID NO: 1-1,074,930. Each sequence is the sequence of a human SNP allele and the ... 03/01/07 - 20070048755 - Assay for determining the sex of primates The present invention relates to methods for identifying the sex of a primate by providing a biological sample collected from the primate and contacting the biological sample with one or more probes that hybridize to a target SRY nucleic acid molecule at a particular location within a consensus SRY nucleotide ... 03/01/07 - 20070048754 - Epidermal growth factor receptor mutations Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“Pl3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant Pl3K, and/or mutant B-Raf ... 03/01/07 - 20070048753 - Sodium channel protein type iii alpha-subunit splice variant The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same. ... 03/01/07 - 20070048752 - Mass tags for quantitative analyses This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes. ... 03/01/07 - 20070048751 - Method of diagnosing type ii diabetes mellitus using multilocus marker, polynucleotide including marker associated with type ii diabetes mellitus, and microarray and diagnostic kit including the polynucleotide Provided are a polynucleotide including a marker associated with type II diabetes mellitus and a method of diagnosing type II diabetes mellitus in an individual, which includes determining a nucleotide of a polymorphic site of at least one polynucleotide of Table 1 in the specification. ... 03/01/07 - 20070048750 - Rapid efficacy assessment method for lung cancer therapy The present invention discloses a method for rapid assessment of lung cancer therapy efficacy in a few days instead of weeks by conventional imaging methods. This method can also be used to detect relapse of the cancer and to improve the current TNM cancer staging method for more accurate prognosis. ... 03/01/07 - 20070048749 - Method for survival prediction in gastric cancer patients after surgical operation using gene expression profiles and application thereof Disclosed is a method for survival prediction in gastric cancer patents after surgical operation, which uses a survival prediction model determined by known statistical method and gene expression microarray profiles. The survival prediction model is established by selecting special genes expressing significantly differential from pairs of cancerous and noncancerous tissue ... 03/01/07 - 20070048748 - Mutant polymerases for sequencing and genotyping The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods. ... 03/01/07 - 20070048747 - Methods for assaying analytes Described herein are methods for assaying analytes. ... 03/01/07 - 20070048746 - Multiplex data collection and analysis in bioanalyte detection Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and ... 03/01/07 - 20070048745 - Systems and methods for partitioned nanopore analysis of polymers Devices, systems, and methods for nanopore analysis of polymers are provided. One exemplary device, among others, includes a substrate having a plurality of partitioned nanopores configured to receive a polymer sample. In addition, the device includes a plurality of sets of resonant tunneling electrodes adjacent the partitioned nanopore. At least ... 03/01/07 - 20070048744 - Single molecule sequencing of captured nucleic acids The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques. ... 03/01/07 - 20070048743 - Methods and compositions for assessing candidate acgh probe nucleic acids Methods for evaluating surface-bound polynucleotides, e.g., candidate aCGH probe nucleic acids, are provided. Specifically, the methods involve contacting an array of surface-bound polynucleotides with a validation nucleic acid composition and assessing binding of the surface-bound polynucleotides. The methods may be used to screen for surface bound polynucleotides that have desirable ... 03/01/07 - 20070048742 - Detection method for chromosome abnormality and microarray chip The present invention relates to a method of detecting a chromosome abnormality and a microarray chip for detecting a chromosome abnormality. More specifically, the present invention is directed to a method of detection for chromosome abnormality in order to easily diagnosing the health condition and disease of the subject by ... 03/01/07 - 20070048741 - Methods and kits for sense rna synthesis Methods and kits are provided for performing sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 03/01/07 - 20070048740 - Full-length cdna Novel full-length cDNAs are provided. 1,995 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information ... 03/01/07 - 20070048739 - Method for identifying biological species The present invention provides a method for identifying species and subspecies in a biological sample through the selective amplification of segments of nucleic acid that code a target region of the cytoplasmatic beta-actin protein, which is present in all the organisms concerned. The method comprises DNA extraction from the sample; ... 03/01/07 - 20070048738 - Methods and compositions for diagnosis, staging and prognosis of prostate cancer The present invention provides, inter alia, novel methods and compositions for the diagnosis, staging and prognosis of prostate cancer, based on DNA methylation and/or modulation of gene expression, including transcriptional silencing. Preferred diagnostic and/or prognostic nucleic acid and protein markers include at least one of: the differentially (relative to benign ... 03/01/07 - 20070048737 - Calcium phosphate ceramics and particles for in vivo and in vitro transfection The invention relates to a method of modifying the surface of calcium phosphate ceramics and powders. The inventive method involves maturation in a culture medium, thereby causing epitaxial carbonated apatite growth at the surface of the aforementioned ceramics and powders. The invention also relates to the use of said modified ... 02/22/07 - 20070042422 - Oligonucleotides for rapidly identifying microbial dna or rna An oligonucoeotide selected from the group consisting of ISN2 (SEQ ID NO: 43), ISN2* (SEQ ID NO: 44), ISN (SEQ ID NO: 34), ISP2 (SEQ ID NO: 46), ISP2* (SEQ ID NO: 45) and ISP (SEQ ID NO: 33). ... 02/22/07 - 20070042421 - Method of identifying nucleic acids Disclosed are methods for identifying nucleic acids in a sample of nucleic acids in which nucleic acids are initially present in unequal amounts. The methods include partitioning the starting population of nucleic acids to form one or more subpopulations, and then identifying nucleic acids that are present in different amounts ... 02/22/07 - 20070042420 - Liver tumor marker sequences Polypeptides whose expression is upregulated in liver tumor cells and cells from liver preneoplastic foci relative to expression in normal liver cells are disclosed as are polynucleotides that encode the polypeptides. In humans, the polynucleotide maps to a region of chromosome 15. The overexpression has also been confirmed in human ... 02/22/07 - 20070042419 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 02/22/07 - 20070042418 - Therapeutic modulation of the fas pathway A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. ... 02/22/07 - 20070042417 - Methods of using zven polynucleotides The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The ... 02/22/07 - 20070042416 - Dendritic enriched secreted lymphocyte activation molecule The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and ... 02/22/07 - 20070042415 - Anti-fused antibodies The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused. ... 02/22/07 - 20070042414 - Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical ... 02/22/07 - 20070042413 - Platelet-derived growth factor d, dna coding therefor, and uses thereof PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in ... 02/22/07 - 20070042412 - Detection of biologically active compounds A probe comprises a supramolecular structure having a chemical or biological recognition moiety; a phosphorescent reporter label; and an effector which interacts with the label so that the probe alters its phosphorescent characteristics on recognition of a target. The phosphorescent reporter label may have an emission lifetime in the order ... 02/22/07 - 20070042411 - Multiplexed pcr assay for detection of bovine spongiform encephalopathy (bse)-associated bovine prion protein gene (prnp) polymorphisms A multiplexed PCR assay system and method are provided for detection of bovine prion protein gene (PRNP) insertion/deletion polymorphisms that are associated with bovine spongiform encephalopathy (BSE), thereby identifying a population of cattle or individual therefrom that possesses an elevated level of putative resistance or susceptibility to BSE. Such system ... 02/22/07 - 20070042410 - Screening method for genes of brewing yeast Provided herein are a method for selecting a gene participating in the desired brewing character and compiling a database of the whole genome sequence of industrial yeast; identifying a gene participating in a brewing characteristic from the database; functional analysis of the gene; and a DNA array of the whole ... 02/22/07 - 20070042409 - Mammalian obestatin receptors A high affinity obestatin receptor is provided; the orphan receptor GPR39. The receptor mediates obestatin activities. The obestatin receptor (GPR39) and fragments thereof, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of obestatin. In addition to use as a therapeutic agent, GPR39 polypeptides are ... 02/22/07 - 20070042408 - Nucleotide sequence for assessing transmissible spongiform encephalopathies The present invention is directed to the assessment of transmissible spongiform encephalopathy (TSE) using a sample from a living individual. The assessment is based on the use of an RNA marker molecule in a sample of whole blood. The RNA encodes a hypothetical cystein protease. The invention is further directed ... 02/22/07 - 20070042407 - Modified nucleosides and nucleotides and uses thereof The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing nucleosides and nucleotides which exhibit enhanced fluorophore intensity by virtue of reduced quenching effects. ... 02/22/07 - 20070042406 - Diffusion mediated clean-up of a target carrier fluid Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier ... 02/22/07 - 20070042405 - Enhanced diagnostic multimarker serological profiling The present invention is related to methods of early diagnosis of ovarian cancer in a patient by determining serum levels of blood markers using a novel LabMAP™ technology (Luminex Corp., Austin, Tex.), which allows for simultaneous measurement of the blood markers in serum. The panel of blood markers offers extremely ... 02/22/07 - 20070042404 - Compositions and method for detecting endonuclease activity The present invention relates to compositions and a cell-based assay for detecting endonuclease activity. The assay involves the basic principle of linking a endonuclease cleavage event with cell survival. When an endonuclease cleaves its cognate endonuclease recognition site located on a vector containing a toxic reporter protein, the vector is ... 02/22/07 - 20070042403 - Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions ... 02/22/07 - 20070042402 - Method for predicting human longevity The present disclosure concerns methods of detecting levels of one or more molecules(s), longevity predicting marker(s), in a sample, and using these levels of the marker(s) to predict a condition. In a particular embodiment, the present invention concerns methods of detecting longevity predicting marker(s), in a sample, preferably to assess ... 02/22/07 - 20070042401 - Methods for synthesis of encoded libraries The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. ... 02/22/07 - 20070042400 - Methods of preparing nucleic acid for detection Methods of preparing nucleic acid from polysaccharide-containing samples for detection by providing one or more glycosidases to the sample to degrade polysaccharides are provided. The nucleic acids can further be extracted from the sample. The method is particularly useful for detecting nucleic acid in samples with high starch content. ... 02/22/07 - 20070042399 - Biological materials and uses thereof The invention relates to a library, methods of making a library of biologically active molecules and uses thereof. The library comprises a plurality of chelating ligand pairs, each said ligand pair including two ligands that bind specifically to distinct epitopes on the same target molecule and the two ligands of ... 02/22/07 - 20070042398 - Cyanine dyes and methods of use The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological ... 02/22/07 - 20070042397 - Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding ... 02/22/07 - 20070042396 - Nucleic acid purification apparatus including photovoltaic device, microfluidic apparatus including the nucleic acid purification apparatus, and method of purifying nucleic acid using the nucleic acid purification apparatus Provided are a nucleic acid purification apparatus including a chamber that includes an inlet and an outlet, at least two electrodes that defines the chamber and form an electric field, a photovoltaic device that applies a bias to the electrodes, a microfluidic apparatus including the same, and a method of ... 02/22/07 - 20070042395 - Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide ... 02/22/07 - 20070042394 - Apparatus for producing a dna doped carbon cluster and method for producing the same The object of the present invention is to provide an apparatus for producing a DNA doped carbon cluster capable of introducing DNA into the cavity of a carbon cluster. An apparatus for producing a DNA doped carbon cluster comprising a radio frequency current applying electrode which is composed of a ... 02/22/07 - 20070042393 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 02/22/07 - 20070042392 - Novel nucleic acids and polypeptides The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof. ... 02/22/07 - 20070042391 - Nucleic acid and amino acid sequences relating to staphylococcus epidermidis for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 02/22/07 - 20070042390 - Method and device for critical dimension detection by molecular binding Critical Dimension (CD) of features on a semiconductor substrate may be indicated utilizing the site-specific binding properties of organic or biological molecules. In accordance with one embodiment of the present invention, a fluorescent tagged organic molecule is fabricated having a length corresponding to the desired CD. The semiconductor substrate is ... 02/22/07 - 20070042389 - Method and sequences for determinate nucleic acid hybridization Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be ... 02/22/07 - 20070042388 - Method of probe design and/or of nucleic acids detection It is provided a method of designing oligonucleotide probe(s) for nucleic acid detection comprising the following steps in any order: (i) identifying and selecting region(s) of a target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE; and (ii) designing oligonucleotide ... 02/22/07 - 20070042387 - Promoter, promoter control elements, and combinations, and uses thereof The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels. ... 02/22/07 - 20070042386 - Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system The present invention contemplates monitoring the amplification of nucleic acid using chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one ... 02/22/07 - 20070042385 - Novel compositions and methods in cancer The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention ... 02/22/07 - 20070042384 - Method for isolating and modifying dna from blood and body fluids This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses. ... 02/22/07 - 20070042383 - Mycobacterial diagnostics The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for ... 02/22/07 - 20070042382 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods ... 02/22/07 - 20070042381 - Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known ... 02/22/07 - 20070042380 - Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof The present invention relates to a first group of novel oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known “target” genes, many of which are known ... 02/22/07 - 20070042379 - Modified dna cleavage enzymes and methods for use (as amended by isa) Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme ... 02/22/07 - 20070042378 - Regulation of prokaryotic gene expression with zinc finger proteins Chimeric zinc finger proteins, and methods of using zinc finger proteins for regulating gene expression in prokaryotes are disclosed herein. ... 02/22/07 - 20070042377 - Biosensor A sensor for determining the presence of an analyte in a test sample, said sensor comprising a nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIII3 or VIIII3 of the Periodic Table, ... 02/22/07 - 20070042376 - Mn/ca ix and cancer prognosis Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic/neoplastic diseases subject to the prognostic methods of this ... 02/22/07 - 20070042375 - Isolated berovin photoprotein and use thereof The invention relates to the photoprotein berovin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein berovin. ... 02/22/07 - 20070042374 - Novel protein The present invention provides a protein containing the same or substantially the same amino acid sequence as the amino acid sequence starting at Amino Acid No. 1 in the amino acid sequence shown by SEQ ID NO:2 or 4, the nucleic acid that encodes it, a method of screening a ... 02/22/07 - 20070042373 - Protein identification methods and systems The present invention relates to methods and systems for identifying proteins. In particular the invention provides a method for identifying a protein through amino acid sequences of one or more query peptides generated from the protein. The method involves translating amino acid sequences of the query peptides to all possible ... 02/22/07 - 20070042372 - Method for designing dna codes used as information carrier The present invention provides a method for designing DNA code consisting of a set of information codes as an information carrier to write optional information into an optional noncoding region not including any DNA genetic information which can avoid an error occurring when the designed DNA is used. A set ... 02/22/07 - 20070042371 - Mptens as modifers of the pten/igf pathway and methods of use Human MPTEN genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of PTEN/IGF, comprising screening for agents that modulate the activity of MPTEN are provided. ... 02/22/07 - 20070042370 - Fluorescent substrates for detecting organophosphatase enzyme activity Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and ... 02/22/07 - 20070042369 - Methods of selection, reporting and analysis of genetic markers using borad-based genetic profiling applications Disclosed are a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals ... 02/22/07 - 20070042368 - Detection and monitoring of lung cancer Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used, ... 02/22/07 - 20070042367 - Lab-on-chip system for analying nucleic acid This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and ... 02/22/07 - 20070042366 - Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same Featured are devices and systems embodying one or more solid-state nanopores useable for sensing and/or characterizing single macromolecules as well as sequencing DNA or RNA and/or determining RNA secondary structures. In once solid state nanopore of the present invention the width and/or length of the nanopore is defined or established ... 02/22/07 - 20070042365 - Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid A method for detecting the presence of a target nucleic acid in a sample including treating a sample containing nucleic acid with an agent that modifies unmethylated cytosine; providing to the treated sample a detector ligand in the form of an intercalating nucleic acid (INA) capable of binding to a ... 02/22/07 - 20070042364 - Target genes for inflammatory bowel disease Two genes have been discovered that show single nucleotide polymorphisms that are differentially expressed in patients with inflammatory bowel disease (IBD) as compared to unaffected controls. These two genes, FLJ21425 and CSF1R (colony stimulating factor 1 receptor), are located close together on chromosome 5q33 which was known to have other ... 02/22/07 - 20070042363 - Novel polypeptide and nucleic acid encoding the same A novel protein which binds with tumor necrosis factor receptor associated factor 2, TRAF2, as well as a nucleic acid coding for the protein is disclosed. From a mouse cDNA library, a cDNA coding for a novel protein which binds with TRAF2 was discovered by mammalian two-hybrid assay, the cDNA ... 02/22/07 - 20070042362 - Methods and apparatus for use in genetics classification including classification tree analysis Methods and apparatus for use in genetic trait classification involving at least two genes associated with a genetic trait are described. In one illustrative method, a value for use in classifying an individual into one of a plurality of trait classes associated with the genetic trait is calculated. The value ... 02/22/07 - 20070042361 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and ... 02/22/07 - 20070042360 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers. ... 02/15/07 - 20070037205 - Methods and apparatus for cell based screening Methods, kits and systems for identifying at least one compound, from a set of compounds, that modulates the growth or biological activity of a cell. Also high-throughput, tumor cell-based screening assay methods for identifying one or more cell-growth modulating compounds from among a library of compounds. ... 02/15/07 - 20070037204 - Gene overexpressed in cancer Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide ... 02/15/07 - 20070037203 - Novel 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, ... 02/15/07 - 20070037202 - Potentiation of cancer therapies by znf217 inhibition This invention provides methods, reagents and kits for treating cancer in a patient or subject, e.g., a human. Accordingly, the present methods can be used to monitor the efficacy of a cancer treatment and to treat cancer, e.g., by inhibiting the expression and/or activity of ZNF217 in a neoplastic cell. ... 02/15/07 - 20070037201 - Hybrid model for dna probe design and validation using nonlinear and linear regression methods Methods and systems for selecting oligonucleotide probes for use in microarray applications are provided herein. The described methods use a combination of measured probe performance and predicted probe performance to select probes. Nucleic acid arrays containing probes selected by the described methods are described. Also included are algorithms for performing ... 02/15/07 - 20070037200 - Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's ... 02/15/07 - 20070037199 - Individual discriminating method, as well as array, apparatus and system for individual discriminating test The invention provides a method of individual discriminating. The method includes selecting and using single nucleotide polymorphism satisfying any one of the conditions defined by this invention. ... 02/15/07 - 20070037198 - Methods for genetic analysis Methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait, and for predicting the effectiveness of a drug treatment regimen in an individual. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to ... 02/15/07 - 20070037197 - In vitro recombination method The present invention relates, e.g., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising contacting the ... 02/15/07 - 20070037196 - Method for in vitro recombination The present invention relates, e.g., to an in vitro method, using isolated protein reagents, for joining two double-stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising (a) chewing ... 02/15/07 - 20070037195 - Light transmitted assay beads A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling ... 02/15/07 - 20070037194 - Allelic variation in the serotonin transporter (sert) as an indicator of autism The present invention describes allelic variations in the SERT gene that are linked with the development of autism. ... 02/15/07 - 20070037193 - Modulation of peroxisome proliferator-activated receptors A method of treating a peroxisome proliferators-activated receptors related disease by administering to a subject in need thereof an effective amount of a modulator of 15-keto prostaglandin-Δ13-reductase. Also disclosed are methods of identifying a compound for inhibiting activity of the reductase and of lowering blood glucose levels by administering to ... 02/15/07 - 20070037192 - Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile Methods of purifying antithrombin from a variety of source materials including from the milk of transgenic mammals to enhance its safety profile vis-à-vis the removal and/or the inactivation of contaminants. Contaminants would include particulate matter, viruses, and/or prions. ... 02/15/07 - 20070037191 - Apo-2dcr Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided. ... 02/15/07 - 20070037190 - Dna ligase mutants It is intended to obtain DNA ligase improved in binding ability and reactivity with DNA, particularly thermostable DNA ligase improved in binding ability and reactivity with DNA. The present invention provides a DNA ligase mutant improved in binding ability and reactivity with DNA, which is obtained by partially or completely ... 02/15/07 - 20070037189 - Methods for amplification monitoring and gene expression profiling, involving real time amplification reaction sampling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herein provide methods for monitoring the amplification of one sequence or ... 02/15/07 - 20070037188 - Methods for modulating transcriptional activation using mint proteins The present invention is directed to isolated nucleic acids encoding Mint protein variants having enhanced abilities to modulate the transcriptional activation mediated by the cytoplasmic tail of the amyloid precursor protein (APP) relative to wild-type Mint proteins. The present invention is further directed toward purified Mint protein variants having enhanced ... 02/15/07 - 20070037187 - Identification and quantification of a plurality of biological (micro)organisms or their components Disclosed is a system and method conducting real-time PCR. Unlabeled capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is ... 02/15/07 - 20070037186 - Thyroid fine needle aspiration molecular assay The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes. ... 02/15/07 - 20070037185 - Estimating allele frequencies by small pool pcr Methods of the invention include the application of fluorescent technology, total genome amplification, high throughput automated microsatellite fragment analysis, robotics, and novel computational methods. Computational methods include determining a microsatellite instability (MSI) phenotype (frequency and significance of MSI over multiple loci) using SP-PCR at higher than 0.5 genome equivalents (0.5 ... 02/15/07 - 20070037184 - Methods and kits for evaluating dna methylation Methods and kits are disclosed for determining the degree of methylation of at least one target region. Typically a sample is exposed to a modifying agent to obtain a modified sample comprising a modified nucleotide. At least one target region in the modified sample is amplified. Some of the disclosed ... 02/15/07 - 20070037183 - Diagnostic and therapeutic target for macular degeneration The present invention is based on the discovery of genetic polymorphisms that are associated with ocular diseases and disorders, such as age-related macular degeneration (AMD). In particular, the present invention relates to methods for determining an individuals susceptibility to ocular disorders such as AMD by screening for mutations and/or polymorphisms ... 02/15/07 - 20070037182 - Multiplex assays for inferring ancestry Oligonucleotide primers and probes for detecting Ancestry informative marker (AIMs) polynucleotides that contain a single nucleotide polymorphism or that contain an insertion or deletion, are provided, as are methods of using the oligonucleotide primers and probes to draw an inference as to a trait of an individual. The trait can ... 02/15/07 - 20070037181 - Compositions and methods for detecting pathogen specific nucleic acids in urine The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. ... 02/15/07 - 20070037180 - Site-specific immunization in order to establish antibodies with specificity for the e7 oncoprotein of high-risk hpv's The present invention relates to a method for establishment of antibodies with specificity for high-risk HPVs compared to immunization using the whole antigen of high-risk HPVs, wherein the method includes an exclusion of evolutionary conserved motifs as well as regions with high similarity to E7 proteins of low-risk HPVs, as ... 02/15/07 - 20070037179 - Methods of diagnosing and prognosticating solid tumors and melanoma The invention relates to the diagnosis and prognosis of solid tumors and melanoma by detecting increased cellular levels of A3 receptors in tissue and/or leukocytes obtained from patients with cancer or patients at risk for developing cancer. ... 02/15/07 - 20070037178 - Endocrine cell lines and method of using the same In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or ... 02/15/07 - 20070037177 - Cyp19a1 polymorphisms Isolated CYP19A1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as CYP19A1 allozymes. Methods for determining the aromatase status of an individual also are provided, as are methods for determining if a subject is predisposed to certain clinical conditions. ... 02/15/07 - 20070037176 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 02/15/07 - 20070037175 - Controlling use of oligonucleotide sequences released from arrays A method for controlling the use of oligonucleotide sequences released from arrays, comprises synthesizing a chemical array of oligonucleotides on a substrate under conditions for producing an array of cleavable oligonucleotides that are blocked from enzymatic reactions after cleavage. Methods may also include receiving a chemical array of cleavable oligonucleotides ... 02/15/07 - 20070037174 - Chemiluminescent generated fluorescent labeling A method for detecting a target analyte in a sample having the steps of: binding the target analyte to a solid substrate; binding a reporter to the bound target to form a label enzyme; contacting a chemiluminescent reagent with the label enzyme to produce a fluorescent precipitate; and detecting fluorescence ... 02/15/07 - 20070037173 - Circulating tumor cells (ctc's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the ... 02/15/07 - 20070037172 - Separation and concentration of biological cells and biological particles using a one-dimensional channel This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage of a target particle or object. ... 02/15/07 - 20070037171 - Aptamer-based colorimetric sensor systems The present invention provides an aptamer-based calorimetric sensor system for determining the presence and optionally the concentration of an analyte in a sample. Methods of utilizing the sensor system and kits that include the sensor also are provided. The sensor utilizes a linker and oligonucleotide functionalized particles to form an ... 02/15/07 - 20070037170 - Intravenous immunoglobulin composition A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism ... 02/15/07 - 20070037169 - Selective dehybridization using electrochemically-generated reagent on an electrode microarray The present invention provides a method for selective dehybridization by electrochemically-generated (ECG) reagent on an electrode microarray. The ECG reagent is generated by activation of selected electrodes. Activation alters pH in the vicinity of only the selected electrodes. In one embodiment, the increase or decrease in pH is sufficient to ... 02/15/07 - 20070037168 - Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention ... 02/15/07 - 20070037167 - Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or ... 02/15/07 - 20070037166 - Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same ... 02/15/07 - 20070037165 - Polymorphisms in known genes associated with human disease, methods of detection and uses thereof The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for ... 02/15/07 - 20070037164 - Tumor necrosis factor alpha The present disclosure describes the use of genetic variance information for genes involved in inflammatory or immunologic disease, disorder, or dysfunction. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such ... 02/15/07 - 20070037163 - Nucleic acid and amino acid sequences relating to staphylococcus epidermidis for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 02/15/07 - 20070037162 - Polymorphisms in known genes associated with osteoporosis, methods of detection and uses thereof The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and ... 02/15/07 - 20070037161 - Motoneuronotrophic factor gene sequences The invention is directed nucleic acids associated with sequences encoding motoneuronotrophic factors, which promote the survival, growth, proliferation, or maintenance of mammalian neurons, polypeptides encoded by the sequences, and assays for detecting the sequences. ... 02/15/07 - 20070037160 - Method for the dissociation of the extracellular haemoglobin molecule of <i> arenicola marina </i> and the characterisation of the protein chains forming the molecule and the nucleotide sequences coding for said protein chains The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. ... 02/15/07 - 20070037159 - Tetrahydrofolate synthetase gene By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method of colon cancer are provided. A DNA comprising ... 02/15/07 - 20070037158 - Methods of modulating bone growth, bone remodeling and adiposity The present invention provides a method of determining a modulator of Y receptor associated bone remodeling and/or bone growth and/or adiposity in a human or animal subject. The present invention further provides a method of determining a modulator of Y receptor associated differentiation of a mesenchymal stem cell into an ... 02/15/07 - 20070037157 - Socs-3 promoter methylation in cancer This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression. ... 02/15/07 - 20070037156 - Metalloproteinase gene polymorphism in copd A method for genetic testing relating to chronic obstructive pulmonary disease (COPD), including testing for a single nucleotide polymorphism within the metal loproteinase-9 gene, an exon 6, codon 279 Gln/Arg polymorphism, where in presence of the variant polymorphism, particularly homozygous presence, is predictive of susceptibility to COPD. Further provided are ... 02/15/07 - 20070037155 - Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, ... 02/15/07 - 20070037154 - Fine mapping of chromosome 17 quantitative trait loci and use of same for marker assisted selection Disclosed herein is fine mapping of a quantitative trait locus on Chromosome 17 which is associated with meat traits, growth and fatness. The quantitative trait locus correlates with several major effect genes which have phenotypic correlations with animal growth and meat quality which may be used for marker assisted breeding. ... 02/15/07 - 20070037153 - Method and device for detecting biomolecules The present invention relates to a method for detecting a target biomolecule in a sample comprising a plurality of biomolecules, whereby the target biomolecule is provided with a tag, said tag comprising a catalytic active moiety which catalyses a reaction yielding an insoluble reaction product which precipitates on flexible electrically ... 02/15/07 - 20070037152 - Random array dna analysis by hybridization The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain aspects of the invention, the methods and devices are useful in ... 02/15/07 - 20070037151 - Cd4+ human papillomavirus (hpv) epitopes The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional ... 02/15/07 - 20070037150 - Tyrosine kinome Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were ... 02/15/07 - 20070037149 - Human calcium transporter 1 gene, screening method of calcium absorption regulating factor, and calcium absorption regulating factor An object of the present invention is to provide helpful means which enables: genetic applications such as insertion into an expression vector and transformation of a human CaT1 gene; clarification of a calcium absorption activity mechanism such as the presence of a factor affecting the regulation of a calcium absorption ... 02/15/07 - 20070037148 - Compositions and methods for the treatmetn of natural killer cell related diseases Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed. ... 02/15/07 - 20070037147 - Endogenous retrovirus polypeptides linked to oncogenic transformation HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related ... 02/15/07 - 20070037146 - Biodisc microarray and its fabrication, use, and scanning A biodisc comprises a CD-type optical disc with small feature oligonucleotide probes disposed on its surfaces. The biodisc's probes are either custom-fabricated in-situ with a master-duplicate tandem arrangement of discs that allows one disc and a reading/tracking head to control the probe locations being synthesized pass-by-pass on the duplicate. Or ... 02/15/07 - 20070037145 - Novel compositions and methods for cancer The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially lymphoma carcinomas. In addition, the present invention describes the use of novel compositions for use in screening methods. ... 02/15/07 - 20070037144 - Leukocyte expression profiling Leukocyte gene expression profiling is utilized to identify oligonucleotides from gene expression candidate libraries. The expression libraries are generally immobilized on an array. Diagnostic oligonucleotide sets for analysis of leukocyte-related diseases are described. ... 02/08/07 - 20070031889 - Method for rapidly detecting quinolone-resistant salmonella ssp. and the probes and primers utilized therein The present invention relates to a method for rapidly detecting quinolone-resistant Salmonella spp. The invention also relates to the oligonucleotide primers and probes utilized in the method, which can differentiate mutant strains having one or two single point mutations in gyrA gene or single point mutation in parC gene from ... 02/08/07 - 20070031888 - Human leucine-rich repeat containing protein expressed predominately in small intestine, hlrrsi1 The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention ... 02/08/07 - 20070031887 - Aqueous-based pharmaceutical composition An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the ... 02/08/07 - 20070031886 - Detecting recessive diseases in inbred populations Techniques of using statistical analysis of genetic data to determine likely markers for a recessive genetic disease or trait. One embodiment of these techniques includes the steps of obtaining actual genotype data for one or more affected people with the genetic disease or trait in a population, obtaining estimated genotype ... 02/08/07 - 20070031885 - Materials and methods for detection of nucleic acids Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate ... 02/08/07 - 20070031884 - Universal readout for target identification using biological microarrays A method and apparatus for implementing the method is provided. The method involves performing an indirect competitive binding assay on a microarray to identify biological or chemical targets and screen for compounds of interest. The microarray comprises a common ligand located among membrane-, lipid- or protein-associated active binding sites. The ... 02/08/07 - 20070031883 - Analyzing cgh data to identify aberrations Methods, systems and computer readable media for calling out genetic aberrations. Log ratio noise associated with log ratio signals read from respective probes on at least one array for signals representative of the same chromosomal locations in a test sample of nucleic acids and a reference sample of nucleic acids ... 02/08/07 - 20070031882 - Methods and compositions for treating aids and hiv-related disorders using 1414, 1481,1553, 34021, 1720, 1683, 1552, 1682, 1675, 12825, 9952, 5816, 10002, 1611, 1371, 14324, 126, 270, 312, 167, 326, 18926, 6747, 1793, 1784 or 2045 molecules The present invention relates to methods for the diagnosis and treatment of AIDS or an HIV-related disorder or disorders. Specifically, the present invention identifies the differential expression of 1414, 1481, 1553, 34021, 1720, 1683, 1552, 1682, 1675, 12825, 9952, 5816, 10002, 1611, 1371, 14324, 126, 270, 312, 167, 326, 18926, ... 02/08/07 - 20070031881 - Immunoassays to detect diseases or disease susceptibility traits Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gene or genes are immunologically quantitated in biological samples. Results indicating that a ... 02/08/07 - 20070031880 - Chemical treatment of biological samples for nucleic acid extraction and kits therefor A composition and method for the purification of nucleic acid are disclosed. The composition includes at least one alkaline agent and at least one detergent. The composition preferably also includes a suspension of paramagnetic particles and an acidic solution. The method involves the use of the composition with paramagnetic particles ... 02/08/07 - 20070031879 - Novel enterokinase cleavage sequences Novel enterokinase cleavage sequences are provided. Also disclosed are methods for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion construct on a solid substrate. Preferred ... 02/08/07 - 20070031878 - Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. ... 02/08/07 - 20070031877 - Support for analyte determination methods and method for producing the support A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with ... 02/08/07 - 20070031876 - Methods of providing gene expression profiles for metastatic cancer phenotypes utilizing differentially expressed transcripts associated with circulating tumor cells Methods of identifying the presence of differentially expressed transcripts associated with the presence of at least one circulating tumor cell in a biological sample of a cancer patient involves the use of suppression subtractive hybridization to identify differentially expressed transcripts present in biological samples of cancer patients not present in ... 02/08/07 - 20070031875 - Signal pattern compositions and methods The invention relates to compositions and methods for a temporal signal pattern or signature representative of a characteristic of a nucleic acid template. The signature is created by monitoring the real time sequential pattern of signal emissions generated during nucleic acid template-dependent polymerization reactions. ... 02/08/07 - 20070031874 - Modulating sos response induction by antimicrobial agents Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can ... 02/08/07 - 20070031873 - Predicting bone relapse of breast cancer A method of providing predicting relapse of breast cancer in bone is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them. ... 02/08/07 - 20070031872 - A141s and g399s mutation in the omi/htra2 protein in parkinson's disease The present invention relates to a method for diagnosing Parkinson's disease in a human being; nucleic acid molecules used in this method; a nucleic acid molecule which encodes a human Omi/HtrA2 protein which has a genetic modification at amino acid position 141 and/or 399 compared with the wild type, and ... 02/08/07 - 20070031871 - Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Also provided are methods of selecting a ... 02/08/07 - 20070031870 - Methods and reagents for detecting target nucleic acids The present invention provides methods and probe nucleic acids for detecting mutant forms of target nucleic acids that comprise repetitive nucleotide sequences. In certain embodiments, for example, these approaches and reagents can be used to detect instability in regions of genomic DNA that include microsatellite markers. The invention also provides ... 02/08/07 - 20070031869 - Template specific inhibition of pcr Template specific inhibition during PCR (TSI-PCR) allows specific inhibition of particular templates without disrupting the amplification of other templates that share amplification primer binding sites. TSI-PCR is achieved by ligation of stop oligos comprising a 3′ modification that prevents extension by DNA polymerases. Stop oligos hybridize to a region of ... 02/08/07 - 20070031868 - Method of detection of sp-a2 gene variants useful for prediction of predisposition to aspergillosis Allele specific primers and probes suitable for detecting allelic variants of human SP-A2 gene for applications such as molecular diagnosis, prediction of an individual's susceptibility, and/or the genetic analysis of SP-A2 gene in a population. ... 02/08/07 - 20070031867 - Molecular/genetic aberrations in surgical margins of resected pancreatic cancer represents neoplastic disease that correlates with disease outcome The present invention relates to the detection of field cancerization by detection of aberrations in tumor target genes at the margins of resected tumors, and the use of such information to predict survival in cancer patients. Methods for treatment of cancer based thereon also are provided. ... 02/08/07 - 20070031866 - Detection of vancomycin-resistant enterococcus spp. The invention provides methods to detect vancomycin-resistant enterococci in biological samples using real-time PCR. Primers and probes for the detection of vancomycin-resistant enterococci are provided by the invention. Articles of manufacture containing such primers and probes for detecting vancomycin-resistant enterococci are further provided by the invention. ... 02/08/07 - 20070031865 - Novel process for construction of a dna library The invention is directed to processes for constructing DNA Libraries in which ssDNA containing a chemical modification (CM) at or near the 5′- or 3′-terminus is prepared from a RNA or DNA source, a 1st universal oligonucleotide (Oligo A′) is ligated to the 3′-of the ssDNA, and a 2nd universal ... 02/08/07 - 20070031864 - Polyvalent cation-sensing receptor in atlantic salmon The present invention encompasses four full length nucleic acid and amino acid sequences for PolyValent Cation-Sensing Receptors (PVCR) in Atlantic Salmon. These PVCR have been named SalmoKCaR#1, SalmoKCaR#2, SalmoKCaR#3, and SalmoKCaR#4. The present invention includes homologs thereof, antibodies thereto, and methods for assessing SalmoKCaR nucleic acid molecules and polypeptides. The ... 02/08/07 - 20070031863 - Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering ... 02/08/07 - 20070031862 - Preparation of plastic supports for biochips Plastic substrates, including poly(methyl methacrylate) (PMMA) and poly(ethylene terephthalate) (PET) slides, may be modified with methods described herein and subsequently used in the manufacture or formation of biochips, or other microarrays. Illustrative methods include modifying the surface of the plastic substrates by covalent attachment of unsaturated acid derivatives that include ... 02/08/07 - 20070031861 - Methods for determining nucleotide sequence information Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences ... 02/08/07 - 20070031860 - G-protein coupled receptor and uses therefor The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based ... 02/08/07 - 20070031859 - Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries ... 02/08/07 - 20070031858 - Isolation of cpg islands by thermal segregation and enzymatic selection-amplification method The present invention concerns isolation, library preparation and selective amplification from a compositionally heterogeneous pool of DNA fragments of a fraction of molecules, such as those originating from promoter CpG islands and characterized by a high GC content. In particular, the process utilizes a heat-induced segregation of DNA molecules into ... 02/08/07 - 20070031857 - Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the ... 02/08/07 - 20070031856 - Biodisc microarray and its fabrication, use, and scanning A biodisc comprises a CD-type optical disc with small feature oligonucleotide probes disposed on its surfaces. The biodisc's probes are either custom-fabricated in-situ with a master-duplicate tandem arrangement of discs that allows one disc and a reading/tracking head to control the probe locations being synthesized pass-by-pass on the duplicate. Or ... 02/08/07 - 20070031855 - Receptor for a bacillus thuringiensis toxin The cDNA that encodes a glycoprotein receptor from the tobacco hornworm which binds a Bacillus thuringiensis toxin has been obtained and sequenced. The availability of this cDNA permits the retrieval of DNAs encoding homologous receptors in other insects and organisms as well as the design of assays for the cytotoxicity ... 02/08/07 - 20070031854 - Novel 10,10'-substituted-9,9'-biacridilidine luminescent molecules their preparation and uses Novel symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridines and the synthesis of such symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridine molecules and their derivatives is disclosed. These molecules are shown to produce light by luminescence in the presence of signals. These symmetric, uniformly symmetric or asymmetric 10,10′-substituted-9,9′-biacridines are used alone or attached ... 02/08/07 - 20070031853 - Gene sequence variations with utility in determining the treatment of neurological or psychiatric disease The present disclosure describes the use of genetic variance information for genes involved in neurologic and phychiatric diseases and in the selection of effective methods of treatment of such disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods ... 02/08/07 - 20070031852 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 02/08/07 - 20070031851 - Characterization of the yeast transcriptome Yeast genes which are differentially expressed during the cell cycle are described. They can be used to study, affect, and monitor the cell cycle of a eukaryotic cell. They can be used to obtain human homologs involved in cell cycle regulation. They can be used to identify antifungal agents and ... 02/08/07 - 20070031850 - Nucleic acid arrays for detecting multiple strains of a non-viral species Nucleic acid arrays and methods of using the same for concurrent or discriminable detection of different strains of a non-viral species. In many embodiments, the nucleic acid arrays of the present invention include probes that are specific to different respective strains of a non-viral species. In many other embodiments, the ... 02/08/07 - 20070031849 - Three-dimensional structure of dna recombination/repair protein and use thereof A crystal of DNA recombination/repair protein, Rad52 protein is prepared and the three-dimensional structure thereof is determined by X-ray crystallography with the use of the same. The obtained three-dimensional structure of Rad52 protein can be used for screening a variety of mutant enzymes or compounds which binds to the enzyme ... 02/08/07 - 20070031848 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods ... 02/08/07 - 20070031847 - Genetic polymorphisms associated with stenosis, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of ... 02/08/07 - 20070031846 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods ... 02/08/07 - 20070031845 - Compositions, methods and systems for inferring bovine breed Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying breed or breed combinations for ... 02/08/07 - 20070031844 - Functional and hyperfunctional sirna Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. ... 02/08/07 - 20070031843 - Bioinformatically detectable group of novel regulatory bacterial and bacterial associated oligonucleotides and uses thereof The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known ... 02/08/07 - 20070031842 - 379 human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic ... 02/08/07 - 20070031841 - Method for the detection of gene transcripts in blood and uses thereof The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation ... 02/08/07 - 20070031840 - Nucleic acids specifically binding bioactive ghrelin The present invention is related to a nucleic acid specifically binding bioactive ghrelin, more preferably n-octanoyl ghrelin, and its use for the diagnosis of grelin mediated diseases and disorders. ... 02/08/07 - 20070031839 - Identification of pharmaceutical targets An equivalence relationship is created between a) the functional network of the genome and proteome and b) a neuronal network. Both networks represent highly cross-linked feedback systems. The equivalence relationship makes it possible to model the functional network of proteins of and genes by an equivalent artificial neuronal network. The ... 02/08/07 - 20070031838 - Method This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in ... 02/08/07 - 20070031837 - Genetic markers for skatole metabolism Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel ... 02/08/07 - 20070031836 - Bacteria with increased levels of protein secretion, nucleotide sequences coding for a seca protein with increased levels of protein secretion, and methods for producing proteins The invention relates to bacteria that have increased levels of protein secretion due to genetic modification, to nucleotide sequences and gene structures containing at least one gene coding for a SecA protein having increased levels of protein secretion, to a SecA having increased levels of protein secretion, and to a ... 02/08/07 - 20070031835 - Diagnosis of advanced cancer The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of advanced cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of advanced prostate cancer in a mammal. The present invention contemplates a method for ... 02/08/07 - 20070031834 - Test methods for determining the intracellular concentration of cyclic nucleotides The invention relates to methods for the quantitative optical analysis of the intracellular concentration of the cyclic nucleotides cGMP and cAMP, said methods using cell lines which express a combination of certain CNG channels, a calcium-sensitive photoprotein, and different target proteins for which modulators are to be found, in a ... 02/08/07 - 20070031833 - Method for examining obesity or leanness In the examination of obesity or leanness, the examination is based on the expression level of the MCP-1 gene or the MCP-1 protein in a tissue or cell analyte, or on the polymorphism in the gene. In the evaluation of compounds, including screening for therapeutic agents for obesity or leanness, ... 02/08/07 - 20070031832 - Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom Methods for producing nucleic acid fragment libraries that express highly diverse peptide domains, wherein the nucleic acid fragments are derived form microorganisms or eukaryotes with compact genomes. Also peptides derived form the libraries wherein the peptides are selected on the basis of their abilities to bind selected target proteins, including ... 02/08/07 - 20070031831 - Method of monitoring genomic instability using 3d microscopy and analysis The present invention relates to a method of detecting and monitoring genomic instability in a cell using three-dimensional analysis to assess telomeric and/or chromosomal organization. In addition, the invention relates to a method and system for characterizing the 3D organization of telomeres and/or chromosomes. The system includes an input module ... 02/08/07 - 20070031830 - Process for the determination of the primary structure of the messenger rna coding for the human recombinant endooligopeptidase a (heopa)(af217798)... This invention refers to the recombinant human endooligopeptidase (hEOPA), polynucleotide which codes for the hEOPA, polynucleotide which allow the expression of the EOPA in prokaryotes and eukaryotes, including the human beings; use of the synthetic substrates for the determination of the proteolytic activity of the hEOPA, or of its chaperon ... 02/08/07 - 20070031829 - Oligonucleotides for genotyping thymidylate synthase gene Oligonucleotides for genotyping the thymidylate synthase gene are provided. The number of tandem repeats in the promoter region of the thymidylate synthase gene can be identified based on the hybridization of an oligonucleotide of the invention to the genomic DNA of a subject. Therefore, the genotype of the thymidylate synthase ... 02/01/07 - 20070026453 - Classification of patients having diffuse large b-cell lymphoma based upon gene expresson Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression ... 02/01/07 - 20070026452 - Aspartoacylase gene, protein, and methods of screening for mutations associated with canavan disease Canavan disease, an autosomal recessive leukodystrophy, is caused by deficiency of aspartoacylase and accumulation of N-acetylaspartic acid in brain. Human aspartoacylase (ASP) cDNA spanning 1,435 bp has been cloned and expressed in E. coli. A base change, a854>c, has been found in 85% of the 34 Canavan alleles tested so ... 02/01/07 - 20070026451 - Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling ... 02/01/07 - 20070026450 - Methods for the treatment of carcinoma The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to ... 02/01/07 - 20070026449 - Novel human sodium-dependent phosphate cotransporter The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists ... 02/01/07 - 20070026448 - Polynucleotide encoding a novel human g-protein coupled receptor, hbprbmy39 The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention ... 02/01/07 - 20070026447 - Nucleotides The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme ... 02/01/07 - 20070026446 - Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites. ... 02/01/07 - 20070026445 - Novel steroid-activated nuclear receptors and uses therefor A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes ... 02/01/07 - 20070026444 - Thermal cycling in polymerase chain reactions by thermodynamic methods Systems and methods for rapid thermal cycling in a polymerase chain reaction (“PCR”). Thermodynamic work is performed, directly, or indirectly, or both, on or by analyte and reagents comprising a PCR mixture. The thermodynamic work, which is typically adiabatic, reversible, and isentropic, causes a rapid and uniform change in the ... 02/01/07 - 20070026443 - Diagnosis of uniparental disomy with the aid of single nucleotide polymorphisms The present invention relates to a method for diagnosing uniparental disomy (UPD) in a human being via the analysis of the inheritance of informative single nucleotide polymorphisms (SNPs). ... 02/01/07 - 20070026442 - Analytical method and device A method is provided that conveniently allows rapid amplification of nucleic acids. Two different heat sources are used to heat the reaction mixture. ... 02/01/07 - 20070026441 - Methods for reducing viral load in hiv-1-infected patients This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides ... 02/01/07 - 20070026440 - Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal ... 02/01/07 - 20070026439 - Fluid processing device and method A fluid processing device and methods are provided that can process one or many different fluid samples, detection for each of which can be multiplexed to detect the presence or absence of each of a panel of target sequences, for example 20 different target sequences. The device can comprise a ... 02/01/07 - 20070026438 - Methods of producing and sequencing modified polynucleotides The present invention encompasses methods for producing a modified polynucleotide sequence that comprises a (e.g., one or more) phosphorothiolate linkage, methods for determining a polynucleotide sequence comprising a (e.g., one or more) phosphorothiolate linkage, and methods for separating forward and reverse extension products that comprise a (e.g., one or more) ... 02/01/07 - 20070026437 - Novel bmp products Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... 02/01/07 - 20070026436 - Glucose transport-related genes, polypeptides, and methods of use thereof Methods and compositions for modulating glucose transport are provided herein. ... 02/01/07 - 20070026435 - Hydroxysilane functionalized magnetic particles and nucleic acid separation method A method for obtaining nucleic acids from a sample, includes: providing the sample including nucleic acids and other components; providing paramagnetic particles including a metal oxide core and a hydroxysilane (preferably a hydroxyalkyltrialkoxysilane) coating; contacting the sample with the paramagnetic particles under binding conditions such that the nucleic acids bind ... 02/01/07 - 20070026434 - Mobility-modified nucleobase polymers and methods of using same The present invention relates generally to nucleobase polymer functionalizing reagents, to mobility-modified sequence-specific nucleobase polymers, to compositions comprising a plurality of mobility-modified sequence-specific nucleobase polymers, and to the use of such polymers and compositions in a variety of assays, such as, for example, for the detection of a plurality of ... 02/01/07 - 20070026433 - Epitope testing using soluble hla The present invention relates generally to a methodology for assaying the binding of a peptide to an individual, specific, soluble HLA molecule using fluorescence polarization. The peptides utilized in the method may be identified by indirect methods utilizing T lymphocytes, or by a direct method of epitope discovery described herein. ... 02/01/07 - 20070026432 - Separation and purification of nucleic acid from paraffin-containing samples Disclosed are rapid and reproducible methods for separating and purifying nucleic acids from paraffin-containing tissue samples. The disclosed methods involve a melting step, where paraffin-containing tissue samples are heated in the presence of a detergent, causing the paraffin to melt and tissue sample cells to lyse. From the resulting two-phase ... 02/01/07 - 20070026431 - Modulation of mapk-mediated phosphorylation and/or fbxw8-mediated ubiquitinylation of cyclin d1 in modulation of cellular proliferation The invention features methods and compositions for screening for agents that modulate cellular proliferation, particularly in cells that have elevated cyclin D1 (e.g., cancerous cells), where the methods provide for detection of agents that modulate phosphorylation of cyclin D1 by MAPK and/or detection of agents that modulate ubiquitination of cyclin ... 02/01/07 - 20070026430 - Proximity probing of target proteins comprising restriction and/or extension The present teachings provide methods, compositions, and kits for detecting target analytes, including proteins. In some embodiments, cleavage reactions are performed in the context of proximity probe reactions that query target proteins, wherein the presence and/or quantity of cleavage products is indicative of the presence and/or quantity of a target ... 02/01/07 - 20070026429 - Binary probe and clamp composition and methods for target hybridization detection Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection of PCR products, by real-time and end-point measurements. Where the probe is an amplification primer, the composition provides an improved method for labelling and ... 02/01/07 - 20070026428 - Combinatorial expression of split caspase molecules The present invention relates to the use of split caspase proteins to determine whether or not promoters are coordinately active, whereby the transcriptional expression of incomplete portions of a caspase protein is controlled by different promoters and coordinate (not necessarily contemporaneous) promoter activity results in formation of an activated caspase ... 02/01/07 - 20070026427 - Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)—RNA complexes, protein-RNA ... 02/01/07 - 20070026426 - System for genetic surveillance and analysis A genetic surveillance system comprises a communications network and at least one reader-analyzer instrument. The reader-analyzer instrument has a communication interface to communicate over the network. The reader-analyzer instrument is adapted to perform genetic assay analysis of a sample obtained from a member of a population and to generate detection-related ... 02/01/07 - 20070026425 - Hepatitis c virus non-structural ns3/4a fusion gene Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the inevntion include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as, methods of making and using ... 02/01/07 - 20070026424 - Gene profiles correlating with histology and prognosis The present invention related to methods and kits for evaluating the histology and prognosis of lung cancer by measuring expression levels of specific gene markers. It is based, at least in part, on the discovery of 99 genes that were found to be differentially expressed among lung cancer subtypes, 30 ... 02/01/07 - 20070026423 - Method and test kit for the detection of target nucleic acids This invention concerns a method for the detection of target nucleic acids or analoga to nucleic acids (targets), wherein at least one pair of labeled oligonucleotides or analoga to oligonucleotides (probes) are used, characterised in that the upstream probe proportionally hybridises to the target with its 5′ end and proportionally ... 02/01/07 - 20070026422 - Vaccine-induced hepatitis b viral strain and uses thereof This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is deposited under Accession Nos. P97121504, P97121505 and P97121506 with the European Collection of Cell Culture on 15th Dec. 1997. This invention also provides ... 02/01/07 - 20070026421 - Method and apparatus for generating thermal melting curves in a microfluidic device The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products. ... 02/01/07 - 20070026420 - Novel egiii-like enzymes, dna encoding such enzymes and methods for producing such enzymes (SEQ ID NO: 5) ... 02/01/07 - 20070026419 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026418 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026417 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026416 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026415 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026414 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026413 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 02/01/07 - 20070026412 - Multiplex pcr for the detection of ampc beta-lactamase genes Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain AmpC beta-lactamases. The primers can be employed in methods to detect the presence or absence of an AmpC beta-lactamase gene in samples, and to identify nucleic acid characteristic of AmpC beta-lactamase genes in samples, particularly, in clinical ... 02/01/07 - 20070026411 - Preparing rna from a wax-embedded tissue specimen In particular embodiments in accordance with the present invention, a wax-embedded tissue specimen is digested and the resulting digested tissue specimen is purified to provide a purified RNA fraction. The purified RNA fraction is treated with one or more enzymes to provide a sample containing dephosphorylated RNA; the sample is ... 02/01/07 - 20070026410 - Nucleoside cyanine dye derivatives for rna labeling and nucleic acid detection and methods for using same Fluorescent adenosine derivatives that can be incorporated into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives have readily detectable cyanine dyes attached. Symmetric derivatives are disclosed that. The transcribed RNAs can be used in a variety of applications including nucleic acid detection and in the study of RNA ... 02/01/07 - 20070026409 - Nucleic acid and amino acid sequences involved in pain The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such differentially expressed sequences and methods of screening agents for the ... 02/01/07 - 20070026408 - Materials and methods for analysis of atp-binding cassette transporter gene expression The invention provides materials and methods for detecting the expression of ABC transporter genes. The materials include sets of primers and PCR amplicons. The sets of primers are used to generate PCR amplicons, wherein each PCR amplicon is a unique portion of an ABC transporter gene. The methods of the ... 02/01/07 - 20070026407 - Novel fine fluorescent particle Novel silica particles having bondable functional groups on the surface thereof and containing a fluorescent rare-earth complex characterized by being uninfluenced by the surrounding environment including a buffer and a substance to be labeled. The silica particles containing a fluorescent rare-earth complex specifically are ones which comprise silica particles containing ... 02/01/07 - 20070026406 - Apparatus and method for classifying multi-dimensional biological data Apparatus and method for classifying multi-dimensional biological data are described. In some embodiments, a methodology for deriving a linear classification rule can be used for predicting a biological activity or a biological state. Advantageously, the methodology described herein facilitates obtaining robust and sparse classifiers that account for uncertainty involved in ... 02/01/07 - 20070026405 - Materials and methods for colorectal cancer screening, diagnosis and therapy The invention provides materials and methods for colorectal cancer screening, diagnosis, and therapy. ... 02/01/07 - 20070026404 - Production characteristics of cattle A single nucleotide polymorphism (SNP) in exon 2 of the cattle IGF2 gene is associated in cattle with phenotypes of increased rib eye area, decreased fat content, decreased marbling, and decreased birth weight. The presence of a C residue at position 150 of SEQ ID NO: 1, results in increased ... 02/01/07 - 20070026403 - Method and systems for identifying micro-rna targets and synthesizing novel micro-rnas and uses of the same Method of identifying a microRNA-recognition element and of generating microRNAs are disclosed. System and computer programs for performing such methods are disclosed. Recombinant nucleic acid molecule comprising a heterologous coding sequences and one or more MREs are also disclosed as are isolated nucleic acid molecule comprising one or more MRE ... 02/01/07 - 20070026402 - Genetic marker of response to atypical antipsychotics and antidepressants methods for use thereof The invention provides methods of identifying candidate psychiatric patients, or patients with movement disorder, for treatment with receptor site or increases density of D2 dopamine receptors. The method comprises determining a patient's DRD2 genotype. Patients having the Taq1A (A1) allele (A1+ allelic status) are candidates for treatment with high dose, ... 02/01/07 - 20070026401 - Method and apparatus for spore disruption and/or detection A method and apparatus for spore disruption and/or detection is provided. The method involves irradiating a sample with laser light, conveniently ultraviolet radiation, to disrupt any spores present and collecting any disrupted material for analysis. The disruption can involve breaking the spore open to release intrasporal DNA which is useful ... 02/01/07 - 20070026400 - Multi-hybridization set for dna microarray related assay The present invention relates to a multi-hybridization set for DNA microarray assay, which comprises: a lower plate in which a DNA microarray is mounted; an upper plate which is coupled to the lower plate, and in which one or more O-rings are attached to the lower surface of the upper ... 02/01/07 - 20070026399 - Diagnosis of gynecological neoplasms by detecting the levels of oviduct-specific glycoprotein The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates ... 02/01/07 - 20070026398 - Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method ... 02/01/07 - 20070026397 - Method for producing second-generation library The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons identifying chemical entities that have participated in the formation of the encoded molecule is provided. In a second step, the library ... 02/01/07 - 20070026396 - Peptides directed against antibodies, which cause cold-intolerance, and the use thereof The invention relates to nucleic acid molecules encoding peptides which are directed against autoantibodies associated with cold allergy, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said nucleic acid molecules and peptides for the treatment of circulatory disorders ... 02/01/07 - 20070026395 - Human cancer-relating genes, the products encoded thereby and applications thereof The invention discloses a human cancer-related gene, LAPTM4B, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID ... 02/01/07 - 20070026394 - Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies The present invention relates to nucleic acid molecules, including antisense, enzymatic nucleic acid molecules, and RNA interference molecules, such as hammerhead ribozymes, DNAzymes, allozymes, siRNA, decoys and antisense, which modulate the expression of prostaglandin D2 (PTGDS), prostaglandin D2 receptor (PTGDR), adenosine receptor, NOGO and NOGO receptor, and IKK genes, such ... 02/01/07 - 20070026393 - Detection of variations in the dna methylation profile The invention describes a set of oligonucleotides as probes for the detection of relevant variations of DNA methylation in a target group of genes, the use thereof for the detection of gene variants with respect to DNA methylation, a medical device which uses a set of oligonucleotides, a method for ... 01/25/07 - 20070020680 - Nucleic acid marker ladder for estimating mass The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one or more restriction endonucleases; the restriction endonuclease digest contains ... 01/25/07 - 20070020679 - Modulation of hif1alpha and hif2alpha expression Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α ... 01/25/07 - 20070020678 - Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides Methods for evenly distributing tags on collections of molecules are provided. Also provided are assay methods that employ the tagged collections. ... 01/25/07 - 20070020676 - Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group A method for manufacturing a biochip and a biochip manufactured by the method are provided. In the biochip manufacturing method, a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently ... 01/25/07 - 20070020675 - Modulation of endothelial lipase expression Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided. ... 01/25/07 - 20070020674 - Novel gene defective in apeced and its use The present invention relates to a method for the diagnosis of a disease related to immune maturation and regulation of immune response towards self and nonself, comprising the steps of detecting in a biological specimen the presence of a DNA sequence comprising the sequence of SEQ ID NO:1. ... 01/25/07 - 20070020673 - Model of autoimmune disease and methods for identifying agents against autoimmune disease Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos −/− mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all ... 01/25/07 - 20070020672 - Nucleic acid melting analysis with saturation dyes Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye ... 01/25/07 - 20070020671 - Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular ... 01/25/07 - 20070020670 - Methods for detecting and confirming minimal disease The present invention provides improved methods for detection of minimal disease. More specifically, the invention provides methods for combining cell sorting with clonality profiling to effectively lower sensitivity limits for disease detection and to provide independent confirmation of the tumor detection without the need for patient specific assay designs. ... 01/25/07 - 20070020669 - Regulation analysis by cis reactivity, racr Methods of detecting affinity interactions between at least two molecules of interest are provided. The method comprises: a. forming a plurality of interactors by coupling each molecule of interest with at least one nucleic acid moiety comprising an identification sequence element and at an association element; b. promoting an association ... 01/25/07 - 20070020668 - Method of manufacturing A method of manufacturing items in parallel. Selected samples of items to be manufactured are subjected to additional steps in a manufacturing process. If such sample items meet the requisite quality control standard, remaining items are subjected to further manufacturing steps. If the sample items which have been further processed ... 01/25/07 - 20070020667 - Methods and compositions for amplifying nucleic acids Methods and compositions for amplifying nucleic acids are provided. ... 01/25/07 - 20070020666 - Differentially expressed genes in large granular lymphocyte leukemia The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL. Another aspect of the invention pertains to therapeutic compositions directed to gene expression and gene products of differentially expressed genes in ... 01/25/07 - 20070020665 - Probes and methods for hepatitis c virus typing using single probe analysis This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3, 4, 5 or 6), or assign ... 01/25/07 - 20070020664 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes. ... 01/25/07 - 20070020663 - Reaction monitoring systems The present invention provides an apparatus for simultaneously monitoring an array of reaction sites for light indicating that a reaction is taking place at a particula site comprising a charge-coupled device (CCD) arranged so that in use the light from a particular reaction site will impinge upon a particular predetermined ... 01/25/07 - 20070020662 - Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention ... 01/25/07 - 20070020661 - Method for obtaining purified rna from viable oocysts The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. ... 01/25/07 - 20070020660 - Expression profiles of peripheral blood mononuclear cells for inflammatory bowel diseases The present invention is directed to the identification of PBMC- and IBD-associated biomarkers that may be used to diagnose inflammatory bowel disease, and optionally, distinguish between PBMCs isolated from a patient with Crohn's disease and PBMCs isolated from a patient with ulcerative colitis. The present invention is further directed to ... 01/25/07 - 20070020659 - Generation of minicircle dna with physiological supercoiling Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein. ... 01/25/07 - 20070020658 - Polymorphisms in fatty acid binding protein 4 (fabp4) gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine ... 01/25/07 - 20070020657 - Methods for detecting circulating tumor cells Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein. ... 01/25/07 - 20070020656 - Snapback oligonucleotide probe The invention relates to compositions and methods for detection of specific nucleic acid sequences during an amplification reaction. The invention further relates to a kit format of said compositions for detection of nucleic acid sequences. The Snapback oligonucleotide probes of the invention comprise a target binding sequence, a hairpin forming ... 01/25/07 - 20070020655 - Identification of tumors and tissues The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples. ... 01/25/07 - 20070020654 - Methods and kits for preparing nucleic acid samples The present invention provides methods for preparing nucleic acid samples. The methods of the present invention are particularly amenable for preparing samples that substantially represent the whole transcripts. In some aspects the methods include a step of reducing the amount of ribosomal RNA in a total RNA sample prior to ... 01/25/07 - 20070020653 - Dna polymerase The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described. ... 01/25/07 - 20070020652 - Methods and compositions for rna interference The invention relates to improved methods of attenuating expression of a target gene in a eukaryotic cell with dsRNA, identifying nucleic acid sequences responsible for conferring a particular phenotype to a cell, alleviating pest infestation in plants, and altering gene expression in an undifferentiated stem cell or the differentiated progeny ... 01/25/07 - 20070020651 - Compositions and methods for the inference of pigmentation traits The invention relates to methods for inferring a genetic pigmentation trait of a human subject from a nucleic acid sample or a polypeptide sample of the subject, and compositions for practicing such methods. The methods of the invention are based, in part, on the identification of single nucleotide polymorphisms (SNPs) ... 01/25/07 - 20070020650 - Methods for detecting proteins The invention provides methods for detecting antigens comprising forming an antibody/antigen complex in which the antibody is coupled to a polynucleotide having a known sequence. The sequence of the polynucleotide is identified in order to identify the antibody, thereby detecting the antigen. ... 01/25/07 - 20070020649 - Chitosan capture of microorganisms for detection Chitosan attached to a support surface is used to capture bacteria for detection purposes. Bacteria are captured with chitosan, lysed, and assayed using primers with sequences specific for nucleic acids of target species. The chitosan coated support serves as a capture device to collect or concentrate bacteria from a sample ... 01/25/07 - 20070020648 - Measurement of mutation load using the p53 gene in human cells from paraffin embedded tissues A method for determining mutation load in a somatic cell is determined by mutation analysis of the p53 gene. The p53 gene has been found to be a useful indicator of predisposition to spontaneous mutations or prior carcinogen exposure. Cells that contain mutated p53 tend to accumulate the mutant protein. ... 01/25/07 - 20070020647 - Methods and reagents for treatment and diagnosis of age-related macular degeneration The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD. ... 01/25/07 - 20070020646 - Use of id4 for diagnosis and treatment of cancer Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer. ... 01/25/07 - 20070020645 - Method of analysis of samples by determination of a function of specific brightness A method for characterizing samples having units, by monitoring fluctuating intensities of radiation emitted, scattered and/or reflected by said units in at least one measurement volume, the monitoring being performed by at least one detection means, said method comprising the steps: a) measuring in a repetitive mode a number of ... 01/25/07 - 20070020644 - Method for detection and characterization of short nucleic acids A method of detecting and characterizing a target short RNA is provided. ... 01/25/07 - 20070020643 - Photocleavable bioreactive agents This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents ... 01/25/07 - 20070020642 - Structural interaction fingerprint Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning ... 01/25/07 - 20070020641 - Reagentless, reusable, bioelectronic detectors employing aptamers A reagentless, reusable bioelectronic DNA, or other oligonucleotide sequence sensor is disclosed. The sensor includes an oligonucleotide (aptamer) probe tagged with a electroactive, redoxable moiety, self-assembled on or near an electrode. This surface-confined oligonucleotide (aptamer) probe structure undergoes hybridization-induced conformational change in the presence of the target which changes the ... 01/25/07 - 20070020640 - Molecular encoding of nucleic acid templates for pcr and other forms of sequence analysis In a first aspect, the present invention provides methods for authenticating a nucleic acid molecule and its sequence with a molecular barcode and batch-stamp. In another aspect, the present invention provides methods for authenticating a nucleic acid amplification product. In a further aspect, the present invention provides compositions for encoding ... 01/25/07 - 20070020639 - Isothermal locus specific amplification Methods are provided for amplifying a template DNA strand using locus-specific primers and enzymes. The method involves denaturing template DNA and then annealing a primer to the single-stranded DNA strand. The primer is then extended using a DNA polymerase. The primer is cleaved downstream of the 3′ end of the ... 01/25/07 - 20070020638 - Variants of the adam 12 gene The invention relates to variants of the ADAM12 gene and the role these variants have to play in the diagnosis and treatment of a number of conditions including cancer, disorders of myogenesis, adipogenesis, cardiac hypertrophy and Alzheimer's disease, and in particular, Late Onset Alzheimer's Disease. ... 01/25/07 - 20070020637 - Full-length cdna Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information ... 01/25/07 - 20070020636 - Method for early detection and monitoring of diseases by analysis of cell-surface-bound nucleic acids This invention relates to noninvasive methods of early detection of different sicknesses, like precancerous state or early stages of cancer development, pathologies of pregnancy, and monitoring of efficacy of anticancer therapy. The method is based on cell-surface extra-cellular nucleic acids from human blood which is divided into plasma and cellular ... 01/25/07 - 20070020635 - Nucleotides for prevention and treatment of bacterial and fungal pathologies A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The ... 01/25/07 - 20070020634 - Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs. ... 01/25/07 - 20070020633 - Treatment of nucleic acid The invention provides methods for treating nucleic acid, particularly nucleic acid that is methylated. In one embodiment, the method can include the steps of (a) providing a denaturing environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as ... 01/25/07 - 20070020632 - Method for selective inhibition of human n-myc gene in n-myc expressing tumors through antisense and antigen peptido-nucleic acids (pna) The present invention refers to sense and antisense peptido-nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases. ... 01/25/07 - 20070020631 - Identification of streptococcus penumoniae serotypes The present invention relates to molecular methods of serotyping Streptococcus pneunoniae, as well as polynu-cleotides useful in such methods. These methods rely on analysing at least a portion of the nucleotide sequence between the 3′ end of the cpsA gene and the 5′ end of the cpsB gene, and/or analysing ... 01/25/07 - 20070020630 - Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening ... 01/25/07 - 20070020629 - Devices for component removal during blood collection, and uses thereof The invention relates to a device and method for collecting blood whereby certain target components are isolated or removed from the blood sample at the time of collecting the blood, as well as methods for using such devices. ... 01/25/07 - 20070020628 - Tkts as mondifiers of the beta-catenin pathway and methods of use Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided. ... 01/25/07 - 20070020627 - Artificial transcription factors Transcription regulating polypeptides that contain a plurality of DNA binding domains are provided. The polypeptides optionally contain one or more transcription regulating domains. Polynucleotides that encode the polypeptides and use of the polypeptides and polynucleotides are also provided. ... 01/25/07 - 20070020626 - Evanescence-based multiplex sequencing method The invention relates to a method and a device for evanescence-based multiplex sequencing of nucleic acid molecules immobilized on a support. ... 01/25/07 - 20070020625 - Sequence of the photorhabdus luminescens strain tt01 genome and uses The present invention relates to the genomic sequence and to nucleotide sequences encoding polypeptides of Photorhabdus luminescens. The present invention further relates to polypeptides involved in operons involved in the biosynthesis of antibiotics or toxins, as well as polypeptides with activity of the antibiotic or toxin. Uses of the aforementioned ... 01/25/07 - 20070020624 - Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/25/07 - 20070020623 - Method for determining homeostasis of the skin Described herein are processes and devices useful for the identification of genes differentially expressed in skin. Preferably, the processes and devices are useful for the in vitro determination of skin homeostasis. Also described is a combination having a plurality of genes differentially expressed in skin compared to other tissues. Biochips ... 01/25/07 - 20070020622 - Dna polymerases and mutants thereof The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may posses both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used ... 01/25/07 - 20070020621 - Genomic plant sequences and uses thereof The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the rice genomic promoter sequences, ... 01/18/07 - 20070015204 - Methods for treating viral infection using il-28 and il-29 IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof ... 01/18/07 - 20070015203 - Infectious bovine viral diarrhea virus The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones. ... 01/18/07 - 20070015202 - Atlastin The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment ... 01/18/07 - 20070015201 - Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells ... 01/18/07 - 20070015200 - Methods for detecting genome-wide sequence variations associated with a phenotype The invention provides methods for determining genome-wide sequence variations associated with a phenotype of a species in a hypothesis-free manner. In the methods of the invention, a set of restriction fragments for each of a sub-population of individuals having the phenotype are generated by digesting nucleic acids from the individual ... 01/18/07 - 20070015199 - Stabilized immunogenic hbc chimer particles A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles is disclosed. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more ... 01/18/07 - 20070015198 - Dna sequence detection of nucleated red blood cells Genetic modification or selection of avians requires that large numbers of birds be genetically analyzed for sequences of interest. Typically, DNA is extracted on an individual basis from samples taken from the birds. Current methods of DNA extraction extract the DNA from blood or other tissues using tedious and time-consuming ... 01/18/07 - 20070015197 - Specific binding agents for kshv vil-6 that neutralize a biological activity A specific binding agent is provided, wherein the specific binding agent specifically binds Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6), and the specific binding agent neutralizes an activity of vIL-6. In one embodiment, the specific binding agent is an antibody. Methods are provided for using a specific binding agent that binds ... 01/18/07 - 20070015196 - Growth factor with acts through erb b-4 rtk A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and ... 01/18/07 - 20070015195 - Modified frt recombination site libraries and methods of use Methods and compositions using populations of randomized modified FRT recombination sites to identify, isolate and/or characterize modified FRT recombination sites are provided. Kits comprising the library populations of FRT sites are also provided, as are methods to make a library of modified FRT recombination sites. The recombinogenic modified FRT recombination ... 01/18/07 - 20070015194 - Methods and kits for diagnosing and treating mental retardation The present invention provides methods, kits, isolated nucleic acid sequences, antibodies and addressable oligonucleotides microarrays which can be for analyzing sequence alterations and detecting the expression level of CC2D1A or nup62 in cells of an individual and thus diagnose nonsyndromic mental retardation (NSMR) and/or infantile bilateral striatal necrosis (IBSN) in ... 01/18/07 - 20070015193 - Glutathione s-transferase sequence variants Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described. ... 01/18/07 - 20070015192 - Method of herbal authentication based on 5s rrna spacer sequences A method for authenticating herbs or plants based on sequences in trnL and/or 5S rRNA coding region. Using this method, the sequences from samples to be authenticated and samples of known identity herbs or plants are compared based on similarity percentage calculation. The authentication may also be based on phylogenetic ... 01/18/07 - 20070015191 - Network of buoyant particles for biomolecule purification and use of buoyant particles or network of buoyant particles for biomolecule purification A network of buoyant particles for clearing lysates of biological material, the network including two or more buoyant particles covalently linked together, wherein the network ranges in size from approximately 30 microns to approximately one centimeter along the network's longest dimension. The buoyant particles may have a silica surface. The ... 01/18/07 - 20070015190 - Novel bioassay system using a nanoparticle The invention is directed to a method for detecting a substance of interest using a nanoparticle containing a first substance and a matrix containing a second substance and detecting the radio signal emitted as a result of complex formation between the first and second substance as well as systems and ... 01/18/07 - 20070015189 - System and method to obtain oligo-peptides with specific high affinity to query proteins The present invention relates to a method for constructing oligo-peptides with high binding affinity for a query protein. ... 01/18/07 - 20070015188 - Multiplex detection of nucleic acids Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, ... 01/18/07 - 20070015187 - Methods for rna profiling The present teachings provide methods, compositions, and kits for detecting micro RNAs (miRNAs). In some embodiments, the miRNAs are quantified from formalin-fixed paraffin-embedded tissue samples in which messenger RNA is degraded. The present teachings take advantage of the observation that most mature miRNAs in vivo are protected by degradation as ... 01/18/07 - 20070015186 - Method, apparatus and system for quantifying the content of genetically modified material in a sample A method including providing an initial test sample including a primary material and a relatively smaller amount of at least one adventitious material; combining the initial test sample with a standard addition of at least one adventitious material to form a final test sample, wherein the standard addition has a ... 01/18/07 - 20070015185 - Lysis and stabilization buffer suitable for inclusion in pcr reactions The present invention provides compositions, methods, and kits for lysing cells, storing nucleic acids, amplifying nucleic acids, and analyzing nucleic acids. Among other things, the compositions, methods, and kits are suitable for one-step lysis and amplification of nucleic acid sequences of interest. In general, the compositions comprise TCEP and a ... 01/18/07 - 20070015184 - Method for identifying an intestinal phenotype The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the ... 01/18/07 - 20070015183 - Biomarkers for huntington's disease The invention relates, in part, to specific genes and set of genes that are selectively expressed in Huntington's disease and their use for the diagnosis and staging of HD. Additionally, the selectively expressed genes are useful in methods to assess HD pathogenesis in cells, tissues, and subjects, and in the ... 01/18/07 - 20070015182 - Generation of single-strand circular dna from linear self-annealing segments The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directing ligation to form dumbbell-shaped monomers followed by heat denaturation to yield single-stranded DNA circles. ... 01/18/07 - 20070015181 - System and methods for nucleic acid and polypeptide selection This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic ... 01/18/07 - 20070015180 - Oligonucleotide probe/primer compositions and methods for polynucleotide detection The invention is related to a labeled oligonucleotide pair for detecting a target nucleic acid and methods, kits and compositions containing the labeled oligonucleotide pair. The labeled oligonucleotide pair forms a complex comprising a nucleic acid primer and a nucleic acid probe. ... 01/18/07 - 20070015179 - Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples The present invention is directed to methods of manufacture of microfluidic chip such as a plastic microfluidic chips, which has channels packed with polymer-embedded particles and uses thereof. The chip of the present invention is designed for application of an untreated biological sample on the chip thus allowing isolation, purification ... 01/18/07 - 20070015178 - Methods of using bone morphogenic proteins as biomarkers for determining cartilage degeneration and aging Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or ... 01/18/07 - 20070015177 - Nucleic acid extraction method The invention relates to a method for the extraction of nucleic acids from microorganisms and to the use thereof in a method for the analysis of a microbial population in a given environment, e.g. a population of microorganisms taken from the air. In particular, the invention relates to an extraction ... 01/18/07 - 20070015176 - Small nucleic acid detection probes and uses thereof The present teachings are directed to compositions, methods, and kits for detecting and quantitating small nucleic acid molecules, including small DNA molecules and small RNA molecules. The detector probes of the current teachings, including single-loop detector probes, double-loop detector probes, and bimolecular detector probes, are designed to selectively hybridize with ... 01/18/07 - 20070015175 - Dna biochip and methods of use The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences ... 01/18/07 - 20070015174 - High throughput formulation screening of drug candidates Methods for screening compounds for their solubility and their solution stability in a variety of diverse formulations and sets of diverse formulations useful for screening compounds for their solubility and their solution stability. ... 01/18/07 - 20070015173 - Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis Purified polynucleotides and polypeptides, and cells of M. smegmatis, M. bovis, M. bovis BCG, or M. africanum are provided. ... 01/18/07 - 20070015172 - Expression profiles for microbial infection The invention provides methods for identifying markers of microbial infection, diagnosing microbial infections, and identifying the specific pathogen(s) involved in a microbial infection based on the signature patterns of gene expression induced in a host in response to different pathogens. The invention includes compositions and kits comprising newly identified markers ... 01/18/07 - 20070015171 - Non-invasive method for isolation and detection of fetal dna A method of detecting the presence or absence of the fetal DNA sequence of interest in fetal DNA derived from a sample of peripheral blood obtained from a pregnant woman is described. The method involves obtaining a sample peripheral blood from a pregnant woman, treating the sample of peripheral blood ... 01/18/07 - 20070015170 - Method and kit for detecting a risk of coronary heart disease Genes, SNP markers and haplotypes of susceptibility or predisposition to CHD or CHD death are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for CHD using polymorphisms in the CHD risk genes are also disclosed. The genes, gene products and agents of the invention are also ... 01/18/07 - 20070015169 - Isolation of nucleic acid using colored buffers The present invention describes isolation of plasmid DNA or nucleic acid material from Escherichia coli (E. coli) or other species of microorganisms, or from other sources. The addition of indicator dyes to the alkaline lysis based purification buffers allows for increased ease of visual monitoring of the mixing and lysis ... 01/18/07 - 20070015168 - Methods for monitoring multiple gene expression The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media ... 01/18/07 - 20070015167 - Method for detecting vesicoureteral reflux or interstitial cystitis This invention provides a novel marker of vesicoureteral reflux or interstitial cystitis and a simple and non-invasive method for detecting vesicoureteral reflux or interstitial cystitis. This method comprises detection of uroplakin expression in a sample obtained from a subject. ... 01/18/07 - 20070015166 - Lateral flow methods and devices for detection of nucleic acid binding proteins Methods and devices are provided for detecting the presence or absence of nucleic acid binding proteins, such as NMP22, and other proteins, in bodily fluids. ... 01/18/07 - 20070015165 - Method for the isolation of rna from biological sources Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding ... 01/18/07 - 20070015164 - Dairy cattle breeding for improved milk production traits in cattle Nucleic acid molecules comprising a SNP site selected from the group consisting of position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), position 213 of bovine signal transducer and activator of transcription (STAT1) coding sequence (SEQ ID NO: 2), position 8514 of the osteopontin (OPN) ... 01/18/07 - 20070015163 - Novel full-length cdna Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information ... 01/18/07 - 20070015162 - 99 human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic ... 01/18/07 - 20070015161 - Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including ... 01/18/07 - 20070015160 - Method of diagnosing disease relating to endometriosis The expression level of a histamine-releasing factor (HRF) polynucleotide in a biological sample of a subject is measured and the HRF polynucleotide content is compared with that of a normal biological sample. An HRF polynucleotide expression level considerably higher than that of the normal biological sample is employed as an ... 01/18/07 - 20070015159 - Methods for detecting aneuploidy using microparticle multiplex detection The present invention provides a method for the detection and sorting of microparticles in a mixture of microparticles. The method of the present invention allows for the detection and sorting of many distinct microparticle classes. Detection and sorting is on the basis of microparticle size, the fluorescence spectrum of any ... 01/18/07 - 20070015158 - Process for increasing ionic charge in mass spectrometry Processes and apparatus are described for the analysis of molecules or fragments thereof, which are capable of carrying multiple charges, by reacting the multiply charged molecules or fragments thereof with other ions using mass spectrometry. ... 01/18/07 - 20070015157 - Method and kit for the specific detection of m. tuberculosis The invention relates to a method and system for the specific detection of a microbacterial tuberculosis (M. tuberculosis) in a biological sample, a difference being made, in particular between M. tuberculosis and other elements of M. tuberculosis complex , i.e. Microbacterium bovis (M. bovis), Microbacterium bovis BCG (M. bovis BCG), ... 01/18/07 - 20070015156 - Aberrantly methylated genes in pancreatic cancer The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant ... 01/18/07 - 20070015155 - Novel protein usable in screening drug improving type 2 diabetes The present invention provides a method of screening a drug for improving type 2 diabetes. A protein CbAP40 binding to c-Cbl is found out. It is further found out that mouse CbAP40 gene shows a remarkable increase in expression amount in the muscle of diabetes model mice compared with a ... 01/18/07 - 20070015154 - Differentially expressed nucleic acids that correlate with ksp expression Nucleic acids that differentially expressed in certain tumors are provided. A variety of classification, screening, diagnostic and treatment methods are provided based upon these differentially expressed nucleic acids. Devices and kits for performing such methods are also disclosed. ... 01/18/07 - 20070015153 - Surface treatment A method for producing a monolayer of molecules on a surface comprises: loading a stamp with seed molecules; transferring seed molecules from the stamp to the surface; and, amplifying the seed molecules via an amplifying reaction to produce the monolayer. The method permit generation of complete monolayers from incomplete or ... 01/18/07 - 20070015152 - Methods for diagnosing and treating schizophrenia The genes encoding SCYA2, GADD45B, S100A8, CDKN1A, IL1RL1, TGM2, MAFF, SERPINA3, GRO1, CD14, KIAA1075, CHI3L1, SERPINH1, MT1X, KIAA0620, TIMP1, NUMA1, DDIT3 and TOB2, are upregulated in the anterior cingulate of schizophrenic patients compared to normal patients and as such are useful drug targets for schizophrenia. Methods of screening, diagnosing and ... 01/18/07 - 20070015151 - Analytical chip with an array of immobilized specific recognition elements for the determination of clinically relevant bacteria and analytical method based thereon The invention is related to an analytical chip for the simultaneous determination of one or more different bacterial 16S-rRNA in a liquid sample comprising—an evanescent field measurement platform, e.g. an optical waveguide, as a solid carrier and—a plurality of specific recognition elements immobilized in discrete measurement areas of known location ... 01/18/07 - 20070015150 - Novel nucleic acid sequences and proteins of tumors and neoplasias of the thyroid gland The Invention relates to a nucleic acid and proteins of tumors and neoplasias of the thyroid gland. Said nucleic acid comprises a nucleic acid sequence selected among the group consisting of SEQ ID No. 1, 3, 4, 9 and SEQ ID No. 11 to 16. The invention also relates to ... 01/18/07 - 20070015149 - Prlz regulatory elements in the treatment of disease and the discovery of therapeutics The compositions and methods of the present invention are based, in part, on a gene designated prostate leucine zipper (PrLZ) and the sequences that mediate its expression. The presence of the leucine zipper indicates that PrLZ encodes a protein that interacts with other proteins. Methods to inhibit the activity of ... 01/18/07 - 20070015148 - Gene expression profiles in breast tissue The present invention results from the examination of tissue from breast carcinomas to identify genes differentially expressed between tumor biopsies and normal tissue. The invention includes diagnostic and screening methods using these genes as well as solid supports comprising oligonucleotide arrays that are complementary to or hybridize to the differentially ... 01/18/07 - 20070015147 - Primary rat hepatocyte toxicity modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of ... 01/18/07 - 20070015146 - Molecular nephrotoxicology modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a ... 01/18/07 - 20070015145 - Nucleic acid and amino acid sequences involved in pain The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such differentially expressed sequences and methods of screening agents for the ... 01/18/07 - 20070015144 - Human cdnas and proteins and uses thereof The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for ... 01/11/07 - 20070009954 - Parallel polymorphism scoring by amplification and error correction This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining ... 01/11/07 - 20070009953 - Method for detecting west nile virus nucleic acids in the 5' non-coding/capsid region Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting very low levels of West Nile virus nucleic acids in the 5′ non-coding/capsid region. ... 01/11/07 - 20070009952 - Nephrin gene and protein The present invention provides for compositions and methods for detecting susceptibility for basement membrane disease, in particular congenital nephrotic syndromes of the Finnish type. The present invention provides for nucleic acids and protein for use in methods and compositions for the diagnosis of disease and identification of small molecule therapeutics ... 01/11/07 - 20070009951 - Gene expression vaccine An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA ... 01/11/07 - 20070009950 - Methods and compositions for vitamin k epoxide reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying ... 01/11/07 - 20070009949 - Paramyxovirus-derived rnp A functional RNP containing negative-strand single-stranded RNA derived from Sendai virus, which has been modified so as not to express at least one envelope protein, has been successfully prepared. An RNP comprising a foreign gene is prepared and inserted into a cell with the use of a cationic liposome, thereby ... 01/11/07 - 20070009948 - Nucleic acid binding polypeptide library The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which ... 01/11/07 - 20070009947 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection ... 01/11/07 - 20070009946 - Identification of viral agents in breast ducts and antiviral therapy therefore Methods and systems for identifying a virus in breast ducts are provided. In addition, antiviral therapy for treating a virally infected breast duct is also provided. Patients with a viral infection identified in the breast ducts may be at risk for developing breast precancer or cancer. ... 01/11/07 - 20070009945 - Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or ... 01/11/07 - 20070009944 - Assay for nucleic acid ligase and nucleic acid nuclease A method of determining activity of a nucleic acid ligase or a nucleic acid nuclease is described. This method comprises the steps of: (i) providing a nucleic acid molecule comprising a hairpin with a single-stranded loop and a double-stranded stem containing a target site for the nucleic acid ligase and/or ... 01/11/07 - 20070009943 - Methods, uses and compositions for determining redisposition to cancers by identifying specific genotypes of cyp1b1 gene The present invention is provides the methods, uses and compositions useful in diagnosis of low-penetrance predisposition to human cancers of various sites wherein constitutional variants of alterations within CYP1B1 gene are analyzed in biological material from examined individual. ... 01/11/07 - 20070009942 - Methods and compositions for evolving hydrogenase genes The invention provides methods and compositions for engineering microbes to generate Hydrogen. Some methods of the invention involve recoding of hydrogenase genes followed by subjecting the recoded genes to annealing-based recombination methods. The invention further provides methods of mating organisms that are transformed with recoded and recombined hydrogenase genes with ... 01/11/07 - 20070009941 - Complementary dnas The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping ... 01/11/07 - 20070009940 - Biomarkers for neuropsychiatric disorders The present invention provides diagnostic markers of neuropsychiatric disorders (e.g., schizophrenia, schizoaffective disorder or serious mood disorders including bipolar disorder and recurrent unipolar disorder) for use in diagnosis, drug screening, therapy monitoring, research and therapeutic applications. In particular, the present invention provides SLC18A1 and TAAR2, and mutations therein, as biomarkers ... 01/11/07 - 20070009939 - Preparation of nucleic acid samples The presently claimed invention provides methods, compositions, and apparatus for studying nucleic acids Specifically, the present invention provides a novel enrichment and labeling strategy for ribonucleic acids In one embodiment, the invention provides enriching for a population of interest in a complex population by diminishing the presence of a target ... 01/11/07 - 20070009938 - Minimalist bzip derivatives that bind to noncanonical gene regulatory sequences The invention provides a method of specifically targeting noncanonical gene regulatory sequences using a minimalist basic region-leucine zipper bZIP derivative. Also provided are methods of modulating transcription and treating diseases and cancers using the minimalist basic region-leucine zipper bZIP derivatives. ... 01/11/07 - 20070009937 - Mapping of proteins along chromatin by chromatin cleavage The present invention is directed to a method for localising, in chromatin or DNA, the binding loci of a chromatin or DNA binding protein comprising the following steps: a) tethering, directly or indirectly, an enzyme with regulatable activity to said chromatin binding protein, b) transiently activating the regulatable enzymatic activity ... 01/11/07 - 20070009936 - Mtor kinase-associated proteins The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening ... 01/11/07 - 20070009935 - Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample Systems, arrangements and methods for a molecular recognition are provided. For example, a particular radiation having wavelength that varies over time and/or a spectral width that is greater than 10 nm can be provided. For example, at least one first electro-magnetic radiation can be provided to at least one sample, ... 01/11/07 - 20070009934 - Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)—RNA complexes, protein-RNA ... 01/11/07 - 20070009933 - Pgc-1beta, a novel pgc-1 homologue and uses therefor The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in ... 01/11/07 - 20070009932 - Promoter engineering and genetic control The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the ... 01/11/07 - 20070009931 - Negative correlation between irp-2 and transferrin receptor expression as a diagnostic of alzheimer's disease A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and ... 01/11/07 - 20070009930 - Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. ... 01/11/07 - 20070009929 - Recombinant antigens for the detection of coxiella burnetii The invention relates to a method for the detection of prior exposure to Coxiella. burnetii infection by antibody-based assays using recombinant, immunodominant C. burnetii polypeptides. The invention also relates to the design of biotin or His-tagged C. burnetii proteins useful in the antibody-based assays as standardized antigen reagents. ... 01/11/07 - 20070009928 - Gene synthesis using pooled dna A method and system for synthesizing one or more pieces of DNA with desired sequences using pooled DNA, the method comprising a hierarchical division phase and a hierarchical assembly phase. In the division phase, the sequences of one or more pieces of DNA with desired nucleic acid sequences are recursively: ... 01/11/07 - 20070009927 - Methods and compositions for prenatal diagnosis of mental retardation Methods and compositions for the diagnosis of mental retardation are provided. ... 01/11/07 - 20070009926 - Biomarkers of resistance to infections in humans and biological applications thereof The invention relates to the use of IL-22 alone or in combination as biomarker of resistance to infections in humans when added to of one or several agonists of the formyl peptide receptors (FPR) receptors family and formyl peptide receptors-like 1 (FPRL 1). Said biomarker is useful in diagnostics, prophylaxis ... 01/11/07 - 20070009925 - Genomic dna sequencing methods and kits The disclosed teachings provide methods and kits for determining the sequence of a gDNA target region comprising multiple amplification steps and sequencing at least part of the amplification product of one or more amplification reactions. ... 01/11/07 - 20070009924 - Thermococcus zilligii dna polymerases and variants thereof Native and variant Thermococcus zilligii DNA polymerases are disclosed, as are methods for using the same for nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis. ... 01/11/07 - 20070009923 - Use of bayesian networks for modeling cell signaling systems Methods of developing and using models of cellular networks by applying a probabilistic graphical model are provided. ... 01/11/07 - 20070009922 - Hot start polymerase reaction using a thermolabile blocker The invention relates to compositions, methods, and kits for hot start polynucleotide synthesis, including extension of primed polynucleotide templates and polymerase chain reaction (PCR). Hot start is provided by a thermally inactivated blocking polymerase protein that binds primed polynucleotide templates and prevents their access to a thermostable nucleic acid polymerase. ... 01/11/07 - 20070009921 - Fragments of virus protein 2 or 3 of polyoma virus as vehicles for active substances The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid sequence A1 which is derived from the C-terminal end of virus protein 2 (VP2) or 3 (VP3) of the ... 01/11/07 - 20070009920 - Drug trial assay system The invention provides a method for improving the efficacy of drug trials, the method comprising the step of screening samples from potential participants for the genetic basis of Gilbert's Syndrome and eliminating or including potential participants in a drug trial in the knowledge of them possessing or not possessing the ... 01/11/07 - 20070009919 - Atm kinase compositions and methods The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided. ... 01/11/07 - 20070009918 - Methods and compositions for regulating t cell subsets by modulating transcription factor activity Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the proto-oncoprotein c-Maf, that regulates expression of the Th2-associated cytokine gene are disclosed. Methods for modulating development of T helper type 1 (Th1) or T ... 01/11/07 - 20070009917 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and ... 01/11/07 - 20070009916 - Guanosine triphosphate-binding protein coupled receptors The object of the present invention is to provide a technique for efficiently extracting GPCR sequences from human genome sequences, thereby comprehensively identifying novel GPCRs. An original automatic system for identifying GPCR sequences is disclosed, and 1035 novel GPCRs are successfully identified from the entire human genome by utilizing the ... 01/11/07 - 20070009915 - Microarray analysis of rna In certain embodiments, the invention provides a method of performing an array analysis, the method including contacting a sample of RNA with an analogous DNA set to provide a DNA/RNA duplex, contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested RNA sample, and ... 01/11/07 - 20070009914 - Labeled complimentary oligonucleotides to detect oligonucleotide-linked ligands Methods for determining the presence of an analyte in a sample are disclosed, in which a capture agent is bound to the analyte at a first epitope and a detection agent is bound at a second epitope, and in which the detection agent includes an oligonucleotide to which a labeled, ... 01/11/07 - 20070009913 - Method of treatment of rna sample The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with an analogous DNA set to provide a DNA/RNA duplex. The analogous DNA set includes at least one sequence analogous to a small RNA. The method includes contacting the ... 01/11/07 - 20070009912 - Novel ion channel preferentially expressed in mammalian taste receptor cells Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms, and methods of correcting taste defects are also provided. ... 01/11/07 - 20070009911 - Diagnostic test kits This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention may be advantageously applied ... 01/11/07 - 20070009910 - Primers, probes and reference plasmid for detection of meat adulteration The present invention relates to a reference plasmid for use in specifically detecting the meat of pig, cattle, sheep, deer, horse and kangaroo. The reference plasmid can be used in rapidly identifying the species of meat and can be used in testing commercial meat products. ... 01/11/07 - 20070009909 - Sorting of carbon nanotubes through arrays A method is described that involves sorting CNT hybrid structures of differing sizes by passing the CNT hybrid structures through an arrangement of fixed structures. The sorting involves a diffusion component in which shorter CNT hybrid structures are scattered through the arrangement of fixed structures to a greater degree than ... 01/11/07 - 20070009908 - Human stanniocalcin-alpha A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. ... 01/11/07 - 20070009907 - Nucleic acid ligands specific to immunoglobulin e and their use as atopic disease therapeutics The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE. ... 01/11/07 - 20070009906 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009905 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009904 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009903 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009902 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009901 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009900 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 01/11/07 - 20070009899 - Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases The present invention provides nucleic acid arrays and methods of using the same for detecting gene expression in animal models of osteoarthritis or other inflammatory diseases. The nucleic acid arrays of the present invention comprise polynucleotide probes for genes that are differentially expressed in osteoarthritis-affected cartilage tissues as compared to ... 01/11/07 - 20070009898 - Method of mass spectrometry A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally ... 01/11/07 - 20070009897 - Method of detecting genetic polymorphism The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3′-end position thereof is a nucleotide complementary to the nucleotide ... 01/11/07 - 20070009896 - Method for detecting mutation and method of inducing the same A novel plant transposon that induces bud mutation, transposase thereof, and a method for efficiently inducing bud mutation by improvement in the transposition efficiency are provided. A novel transposon having terminal inverted repeat sequences (SEQ ID NO: 1 and SEQ ID NO: 2) shown below has been isolated for the ... 01/11/07 - 20070009895 - Method of interaction analysis and interaction analyzer A method is provided in which an extremely small amount of a solution containing a substance to be analyzed can be analyzed with high throughput and without any loss of the solution. The method comprises the steps of introducing into a separation channel a first solution containing a substance that ... 01/11/07 - 20070009894 - Oligonucleotide sequestering agents and method of use The present application provides methods and compositions for use in detecting the presence of a target nucleic acid in a sample. In some embodiments, the methods employ sequestering agents which specifically interact with complementary nucleic acids which will be ligated together if the target nucleic acid is present in the ... 01/11/07 - 20070009893 - Method for isolating and purifying a nucleic acid The present invention is a method for isolating and purifying a nucleic acid, where generation of foams is able to be suppressed whereby the isolation and purification of a nucleic acid are easily and efficiently carried out, the method for isolating and purifying a nucleic acid comprising the step of: ... 01/11/07 - 20070009892 - Method of preparing epitopes chimeric gene vaccine The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries of polyepitope chimeric genes with different sizes and lengths using gene shuffling and random assembly so as to screen polyepitope chimeric gene vaccines. Immunization ... 01/11/07 - 20070009891 - Method for the isolation of expressed sequence tags in plants A method is described for the isolation of Expressed Sequence Tags (ESTs) which are based on the use of suitable quantities of 5-azaCytidine in the germination phase of plants to induce the demethylation phenomenon of the DNA. In this way, it is possible to obtain “totipotent” seedlings, i.e. capable of ... 01/11/07 - 20070009890 - Screen for novel protein inhibitors based upon engineered cell line containing an inducible overactivity gene and compensatory gene The present invention provides a method for identifying the presence of a protein inhibitor of a target protein in a sample, comprising the steps of a) contacting said sample with a cell, wherein said cell contains i) an inducible lethal overactivity mutation in a gene affecting the target protein; and ... 01/11/07 - 20070009889 - Nucleoside derivative, modifed oligonucleotide, method for their syntesis and applicantions thereof New class of metallated nucleoside and nucleotide conjugates containing metallacarborane cage is provided, also oligonucleotides containing metallacarborane modification are disclosed. Nucleosides, nucleotides and oligonucleotides containing metallacarborane cage can be used among others as modified primers in amplification of RNA and DNA, antisense drugs, boron carriers for BNCT, radiopharmaceuticals bearing a ... 01/11/07 - 20070009888 - Compositions, splice variants and methods relating to breast specific genes and proteins The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of ... 01/11/07 - 20070009887 - Genotyping of deafness by oligonucleotide microarray analysis A method for genotyping a subject with respect to a gene or target nucleic acid sequence associated with a pathological condition, said method comprising contacting an allele specific oligonucleotide immobilized to a solid support with a single-stranded from of RNA or DNA from a subject to be tested labeled directly ... 01/11/07 - 20070009886 - Carbohydrate-associated proteins Various embodiments of the invention provide human carbohydrate-associated proteins (CHOP) and polynucleotides which identify and encode CHOP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CHOP. ... 01/04/07 - 20070003973 - Methods and kits for identifying and quantifying rnas and dnas associated with rna and dna binding proteins Methods and kits for identifying RNAs and DNAs associated with an RNA or DNA binding protein via a detector specific for the binding protein or protein bound thereto which is linked to an oligonucleotide capable of directing the synthesis of cDNA copies of RNA or DNA that are in close ... 01/04/07 - 20070003972 - Detection and treatment of cancers of the lung The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of ... 01/04/07 - 20070003971 - Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the ... 01/04/07 - 20070003970 - Pak 2: modulators of lymphocyte activation The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense ... 01/04/07 - 20070003969 - Use of novel cytokine receptors as biomarkers and therapeutic targets in human cancer Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer. ... 01/04/07 - 20070003968 - Methods of detecting polynucleotide kinase and its use as a label Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a specific binding pair. the methods rely on the phosphorylation of an oligonucleotide followed by ligation of ... 01/04/07 - 20070003967 - Method of manufacturing dna chip A method of manufacturing a DNA (deoxyribonucleic acid) chip is provided. The DNA chip has a plurality of transistors formed on a substrate and an organic layer and a DNA probe sequentially stacked on a gate of the transistor. The method includes forming an inter-layer insulation layer on the substrate ... 01/04/07 - 20070003966 - Compositions, kits and methods pertaining to stability modulation of pna oligomer/nucleic acid complexes This invention is related to methods, kits and compositions pertaining to stability modulation of PNA oligomer/nucleic acid complexes. ... 01/04/07 - 20070003965 - Device for quantitative analysis of a drug or metabolite profile A device, in particular a sample preparation device for the quantitative analysis of a drug and/or metabolite profile in a biological sample, which includes an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. ... 01/04/07 - 20070003964 - Method for predicting effectiveness of chemotherapy using anticancer agent The present invention provides a method for predicting an effectiveness of chemotherapy using an anticancer agent with high probability. The effectiveness is predicted based on a comparison of a parameter relating to CDK and/or CDK inhibitor in a tumor cell specimen obtained from a patient, with a corresponding threshold value ... 01/04/07 - 20070003963 - Rna sequence-specific mediators of rna interference The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long ... 01/04/07 - 20070003962 - Rna sequence-specific mediators of rna interference The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long ... 01/04/07 - 20070003961 - Rna sequence-specific mediators of rna interference The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long ... 01/04/07 - 20070003960 - Rna sequence-specific mediators of rna interference The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long ... 01/04/07 - 20070003959 - Oligonucleotide arrangements, processes for their employment and their use Oligonucleotide arrangements are disclosed which, in each case, have at least two oligonucleotide sequences linked via at least one spacer. A process is disclosed using the oligonucleotide arrangements for the amplification and/or detection of nucleic acid sequences with formation of crosslinked conglomerates. The process can be used, for example, for ... 01/04/07 - 20070003958 - Method for measuring melting temperature of nucleic acid hybrid and apparatus for use in the method The melting temperature of a hybrid formed of a first nucleic acid, such as a probe, immobilized on a surface of a substrate and a second nucleic acid hybridizable with the first nucleic acid is measured by detecting formation or dissociation of the hybrid depending upon temperature by an optical ... 01/04/07 - 20070003957 - Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for pcr analysis Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5′ nuclease digestion. ... 01/04/07 - 20070003956 - Approaches to identifying genetic traits in animals Disclosed herein are embodiments to screen an animal for the presence or absence of polymorphisms in the following gene: CKM, SCN4α, and LDHα. ... 01/04/07 - 20070003955 - Normalization of samples for amplification reactions The present invention provides oligonucleotide primers, compositions, methods, and kits for determining the amount of gDNA or the number of cells from which a cell lysate originated. The invention relies on detection and amplification of unique genomic sequences within the genome of an organism of interest to determine the amount ... 01/04/07 - 20070003954 - Protein and antibody profiling using small molecule microarrays Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a ... 01/04/07 - 20070003953 - Detection method for gene expression Provided is a novel approach for generating oligonucleotide probes and the use of these probes in gene expression profiling, by hybridization to test oligonucleotides on arrays or beads. This approach involves labeling of the complement oligonucleotide probes using a mixture of dye or hapten labeled-ddNTPs in solution. The labeled oligonucleotide ... 01/04/07 - 20070003952 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and ... 01/04/07 - 20070003951 - Determining the replicative history of lymphocytes The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted ... 01/04/07 - 20070003950 - Detecting targets by unique identifier nucleotide tags This invention relates generally to the field of target detection. In particular, the present inventions provides for methods and compositions for assaying a plurality of different non-nucleic acid targets or for assaying activities of a plurality of enzymes using, inter alia, oligonucleotide identification (ID) tags. ... 01/04/07 - 20070003949 - Sequencing using tag array The present invention provides methods for determining the sequence of a target nucleic acid with molecular inversion probes. Precircle probes are circularized if the corresponding target is present and the associated tag sequence is amplified and detected by hybridization to an array of probes that are tag complements. The presence ... 01/04/07 - 20070003948 - Semiconductor nanocrystal complexes and methods of detecting molecular interactions using same A water-stable semiconductor nanocrystal complex adapted to act as a FRET donor. The present invention also provides a method of detecting molecular interactions in an aqueous solution between a FRET acceptor and a semiconductor nanocrystal complex that is a FRET donor. ... 01/04/07 - 20070003947 - Detecting genetic risk for periodontal disease A method and kit for the identification of a user's genotypes associated with increased risk for developing periodontal disease are disclosed. The kit includes non-invasive DNA sample collecting means, and disclosed are means for determining certain genotypes which are then compared to those of controls with known periodontal disease status ... 01/04/07 - 20070003946 - Use of biomarkers in screening for insulin resistance The invention relates to methods and biomarkers useful in screening subjects for insulin resistance and for monitoring insulin resistance over time or after medical intervention. ... 01/04/07 - 20070003945 - Method for manufacturing a biosensor element and for testing the same When a biomolecule and a biochemical reactant are detected, a white interference method is used to conduct a noncontact and nondestructive detection, and further to conduct efficient and accurate detection. This method is applied to a biosensor element, whereby non-labeled and noncontact quality control can be achieved. ... 01/04/07 - 20070003944 - Inference of human geographic origins using alu insertion polymorphisms The insertion polymorphisms based on interspersed elements including LINEs and SINEs is used for the inference of an individual's geographic origin. SINE polymorphisms are identical-by-descent, essentially homoplasy-free, and inexpensive to genotype using a variety of approaches. Using a Structure analysis of the Alu insertion polymorphism based genotypes, the geographic affiliation ... 01/04/07 - 20070003943 - Tumor angiogenesis inhibitor alpha 1-antitrypsin The present invention relates generally to biomarkers for cancer. In particular, the present invention provides compositions and methods for inhibiting angiogenesis and regulating tumor growth. The present invention also provides biomarkers for cancer. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening ... 01/04/07 - 20070003942 - Invasive cleavage of nucleic acids The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a ... 01/04/07 - 20070003941 - Systems and methods for automated quality control of polymer synthesis The invention provides systems and methods for evaluating synthetic reactions such as polymer synthesis reactions. Evaluation of a synthetic reaction product can be based on a quantitative measure of synthesis such as coupling efficiency or yield, and various parameters determined from a separation record obtained for the synthetic reaction product. ... 01/04/07 - 20070003940 - Nucleic acid probes for analysis of small rnas and other polynucleotides The invention provides a nucleic acid probe for detecting a polynucleotide. The probe contains a region that base-pairs with a polynucleotide to form a duplex and a Tm enhancement domain that increases the stability of the duplex. The Tm enhancement domain may contain a nucleotide clamp and/or a hairpin structure, ... 01/04/07 - 20070003939 - Melting temperature matching Aspects of the disclosure are generally directed to probes and probe compositions for detecting or quantifying a target. One aspect provides one or more nucleic acid probes having melting temperatures for their respective nucleic acid targets within less than about 15° C. of each other. Another aspect provides arrays including ... 01/04/07 - 20070003938 - Hybridization of genomic nucleic acid without complexity reduction Disclosed are techniques for reliably detecting target sequences in a complex nucleic acid sample, typically in the range of about 400 MB or greater, without employing a complexity reduction technique. The method employs relatively high quantities of a hybridization competitor, e.g., multiple times the amount of nucleic acid sample present. ... 01/04/07 - 20070003937 - Increasing hybridization efficiencies Aspects of the disclosure are generally directed to probes and probe compositions for detecting or quantifying a target. One aspect provides a method for selectively hybridizing a probe to a polynucleotide by contacting a sample containing a first and second polynucleotide with a probe. The probe includes a number of ... 01/04/07 - 20070003936 - Methods for the detection of colorectal cancer This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Preferred markers are dipyrrometheneboron ... 01/04/07 - 20070003935 - Nucleic acid underexpressed in melanoma The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 01/04/07 - 20070003934 - 2-methyl-6-solanylbenzoquinone methyltransferase as target for herbicides The present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase which, when absent, brings about retarded growth and chlorotic leaves, as target for herbicides. In this context, there are provided novel nucleic acid sequences comprising SEQ ID NO:5 and SEQ ID NO:7 and corresponding functional equivalents. Moreover, the present invention ... 01/04/07 - 20070003933 - Mutations in the scl40a100000 gene associated to impaired iron homeostasis The present invention relates to mutations in the SLC40A1 gene coding for the ferroportin 1, associated to impaired iron homeostasis or to non-HFE hereditary hemochromatosis and to methods for the diagnosis of these hereditary diseases based on the identification of said mutations. ... 01/04/07 - 20070003932 - Method of detecting beta 3 adrenaline receptor mutant gene and nucleic acid probe and kit therefor A melting curve analysis is performed for a nucleic acid containing a mutation in a nucleotide sequence resulting in a mutation replacing tryptophan at position 64 in an amino acid sequence of the β3-adrenergic receptor with arginine (B3AR Trp64Arg), by using a nucleic acid probe of which end is labeled ... 01/04/07 - 20070003931 - Methods for selecting medications Methods for selecting a medication for a patient are described that include determining the patient's genotype for a panel of genes and selecting the medication based on the genotype. Articles of manufacture also are provided that include nucleic acid molecules for detecting alleles of genes encoding drug metabolizing enzymes and ... 01/04/07 - 20070003930 - Handling of dna A variety of methods are provided which use a silicon or silicon dioxide channel to extract DNA from a sample and then release it at a later point. The extraction channels are simple to manufacture and reliable in use. Prior art problems with entrainment of gas, liquid and solid material ... 01/04/07 - 20070003929 - Method for identifying, analyzing and/or cloning nucleic acid isoforms The present invention provides a method for identifying, analyzing and/or cloning nucleic acid isoforms comprising the steps of: preparing at least two nucleic acid isoforms, complementary to each other, hybridizing the at least two complementary nucleic acid isoforms and forming double strand RNA/RNA or DNA/DNA hybrids comprising unpaired regions; recovering ... 01/04/07 - 20070003928 - Novel use of edg receptors By using a G protein-coupled receptor protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 5 or SEQ ID NO: 9 (EDG-2 receptor, EDG-3 receptor or EDG-5 receptor) or a salt thereof, prophylactic/therapeutic agents ... 01/04/07 - 20070003927 - Mapk7 as modifier of branching morphogenesis and methods of use Human MAPK7 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAPK7 are provided. ... 01/04/07 - 20070003926 - Nucleic acid sequences from drosophila melanogaster that encode proteins essential for viability and uses thereof Nucleotide sequences are isolated from Drosophila melanogaster that code for proteins essential for viability. These proteins are useful for discovering new insecticides based on the essentiality of the nucleotide sequences for Drosophila viability. Further provided are recombinant proteins and methods for identifying inhibitors to these proteins. Protein inhibitors active in ... 12/28/06 - 20060292628 - Compositions and methods involving direct write optical lithography An improved optical photolithography system and method provides predetermined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled means for dynamically generating the ... 12/28/06 - 20060292627 - Pb39, a gene dysregulated in prostate cancer, and uses thereof A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated ... 12/28/06 - 20060292626 - Methods of analysis of allelic imbalance Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to ... 12/28/06 - 20060292625 - Novel human leucine-rich repeat domain containing protein hllrcr-1 The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention ... 12/28/06 - 20060292624 - Methods for the electrochemical detection of multiple target compounds A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules ... 12/28/06 - 20060292623 - Signature genes in chronic myelogenous leukemia The present invention relates to genetic markers whose expression is correlated with progression of CML. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate chronic phase individuals from those in blast crisis. The invention relates to methods of using these markers to distinguish these ... 12/28/06 - 20060292622 - Application of aprataxin gene to diagnosis and treatment for early-onset spinocerebellar ataxia (eaoh) The present invention provides polynucleotides and proteins, which are involved in early-onset spinocerebellar ataxia with ocular motor apraxia and hypoalbuminemia (EAOH); and methods of using the polynucleotides and/or proteins to treat and/or diagnose EAOH. ... 12/28/06 - 20060292621 - Randomized libraries of zinc finger proteins The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes. ... 12/28/06 - 20060292620 - Genes with es cell-specific expression The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs having base sequences depicted in SEQ ID Nos; 9, 11, 13, 15, 17, 19, ... 12/28/06 - 20060292619 - Method and algorithm for quantifying polynucleotides Machine executable method of analyzing growth curve data to identify the transition from a baseline phase into a growth phase. Applications of the method include analysis of results from time-dependent monitoring of amplicon synthesis in a nucleic acid amplification reaction to quantify a starting amount of a nucleic acid template ... 12/28/06 - 20060292618 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to ... 12/28/06 - 20060292617 - Methods and compositions for analysis of microrna The invention provides methods and systems for detecting and measuring microRNAs. ... 12/28/06 - 20060292616 - Single molecule mirna-based disease diagnostic methods The invention relates to compositions and methods for detecting and quantifying small RNA species such as miRNA, preferably associated with disease detection and diagnosis. ... 12/28/06 - 20060292615 - Compositions and methods for detecting single gene copies in-situ Compositions and methods are provided for detecting single copies of a gene in-situ using brightfield microscopy in detection of various target nucleic acid sequences, such as genes or nucleic acid of microorganisms in a cell. In particular, nucleic acid probes for various target nucleic acid sequences in a cell are ... 12/28/06 - 20060292614 - Methods of gene expression monitoring The invention provides methods of monitoring expression of a plurality of genes in a cell or small population of cells. Preferred methods entail contacting an array of probes with a population of nucleic acids derived from a population of fewer than 1000 cells then determining the relative hybridization of the ... 12/28/06 - 20060292613 - Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating elevated intraocular pressure and conditions associated with elevated intraocular pressure, such as glaucoma. ... 12/28/06 - 20060292612 - Method for the quality control of functionalized surfaces The invention relates to a method which can be used to test firstly a reaction and secondly the distribution of functional groups on a surface. This method is employed in a situation that demands documentation or testing of a distribution of surface functionalization, which is as homogeneous as possible. ... 12/28/06 - 20060292611 - Paired end sequencing The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a large target nucleic acid ... 12/28/06 - 20060292610 - Prognostic meta signatures and uses thereof The present invention relates the novel statistical analyses of gene expression data. In particular, the present invention provides prognostic meta signatures (e.g. representing cancer samples) that identify genes with altered expression across several studies. ... 12/28/06 - 20060292609 - Interferon-beta gene therapy using an improved, regulated expression system The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and ... 12/28/06 - 20060292608 - Comparative genomic hybridization Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative ... 12/28/06 - 20060292607 - Analysis of tissue samples surrounding malignancies The present invention provides a method for analyzing tissue from the surgical margin of resected tumor, and the use of such information to predict recurrence, survival, and treatment efficacy in cancer patients. Methods of treatment based thereon are provided. ... 12/28/06 - 20060292606 - Identification of ligands by selective amplification of cells transfected with receptors The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively ... 12/28/06 - 20060292605 - Method for highly sensitive nucleic acid detection using nanopore and non-specific nucleic acid-binding agent Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the sample comprising the nucleic acid bound to the agent with a ... 12/28/06 - 20060292604 - Compositions and methods for spinocerebellar ataxia The autosomal dominant spinocerebellar ataxias (SCAs) represent a growing and heterogeneous clinical phenotype with ongoing discovery of causative etiologies. Methods: The authors collected DNA and clinically characterized a three-generation Filipino family segregating a dominant ataxia. Following elimination of several known SCA loci, a genome-wide linkage study was undertaken with additional ... 12/28/06 - 20060292603 - Method for selecting a chemical entity from a tagged library Disclosed is a method for determining the identity of a chemical entity having a preselected property. The chemical entity is identified from a library composed of a plurality of different chemical entities each appended to unique identifier tags. An anti-tag having the capability of specifically interacting with the unique identifier ... 12/28/06 - 20060292602 - Dna diagnostic screening for turner syndrome and sex chromosome disorders The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes. ... 12/28/06 - 20060292601 - Rapid genotyping analysis and the device thereof The present invention discloses the use of Allele-Specific-oligonucleotide (ASO) as a detection assay for human HLA classification. Using Reversed-Dot-Blotting format and flow through hybridization process, more efficient, faster and less expensive HLA classification can be achieved. A simplified procedure for HLA genotyping is also described. This invention further provides a ... 12/28/06 - 20060292600 - Methods, compositions and kits for the detection and monitoring of lung cancer Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, teins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be ... 12/28/06 - 20060292599 - Methods to detect lineage-specific cells The present invention is based, at least in part, on methods to identify and quantify lineage-specific cells. The present invention provides methods of detecting lineage-specific cells in a biological sample, and monitoring the effectiveness of progenitor cell transfer in a subject. The invention further provides methods of determining an effective ... 12/28/06 - 20060292598 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human. ... 12/28/06 - 20060292597 - Methods for genotyping with selective adaptor ligation The present invention provides methods for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. Complexity reduction can be accomplished by fragmenting the nucleic acid sample with a restriction enzyme that has at least one variable position in the recognition sequence. In some aspects ... 12/28/06 - 20060292596 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human. ... 12/28/06 - 20060292595 - Electrochemiluminescence detection method for nucleic acid using intercalator Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling. ... 12/28/06 - 20060292594 - Hdac inhibitors that promote brm expression and brm related diagnostics The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a candidate subject with a BRM expression-promoting HDAC inhibitor, and therapeutic methods for treating cancer cells in a patient with a BRM expression-promoting HDAC inhibitor. The present ... 12/28/06 - 20060292593 - Dendritic cell co-stimulatory molecules A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and ... 12/28/06 - 20060292592 - Key probe compositions and methods for polynucleotide detection The invention relates to compositions and methods for detection of nucleic acid sequences. The invention further relates to kit format of said compositions for detection of nucleic acid sequences. Oligonucleotide probes of the invention comprise a target binding sequence and a sequence at least partially complementary thereto, joined by an ... 12/28/06 - 20060292591 - Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases. ... 12/28/06 - 20060292590 - Nod nucleic acids and polypeptides The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins. ... 12/28/06 - 20060292589 - Fluorescent quenching detection reagents and methods Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group. ... 12/28/06 - 20060292588 - Assay systems, kits and methods for detecting microorganisms The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis) of suspected patient. The present invention also relates to an apparatus for performing the integration of thermal and magnetic control in the same apparatus to largely reduce the whole process of M. ... 12/28/06 - 20060292587 - Polynucleotides encoding insect voltage-gated chloride channel and uses thereof The instant invention provides nucleic acids encoding insect chloride channel (CLC channel), as well as CLC channel polypeptides encoded thereby. The invention further provides methods of identifying agents that modulate a level of CLC channel mRNA, polypeptide, or calcium ion channel activity. Such agents are candidate insecticidal compounds. ... 12/28/06 - 20060292586 - Id-tag complexes, arrays, and methods of use thereof The present invention relates to the detection of target sequences. Detection can be achieved through the use of ID-tag complexes. These ID-tag complexes are relatively stable in the absence of a target sequence. In the presence of a target sequence, the complexes dissociate and form new complexes or duplexes, which ... 12/28/06 - 20060292585 - Analysis of methylation using nucleic acid arrays Methods of analyzing DNA to determine the methylation status of a plurality of cytosines are disclosed. In one aspect genomic DNA is fragmented, fragments are circularized, the circles are treated with a methylation sensitive enzyme to enrich for circles with methylated sites or with a methylation dependent enzyme to enrich ... 12/28/06 - 20060292584 - Compositions and methods for accomplishing nucleotide depletion Methods and compositions are provided that achieve depletion of a nucleotide pool by means of a phosphate-transferring enzyme such as a nucleoside phosphate or a polyphosphate glucokinase. Depletion of a nucleotide pool using a nucleoside kinase may additionally utilize a phosphotransferase in a second phosphate-transferring reaction. ... 12/28/06 - 20060292583 - High speed parallel molecular nucleic acid sequencing A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and ... 12/28/06 - 20060292582 - Methods for nucleic acid manipulation A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity ... 12/28/06 - 20060292581 - Biosensor for small molecule analytes A biosensor device for detecting small molecules analytes is provided. The device employs a first class of molecules, e.g., protein that binds to both the analyte and a second class of molecules, e.g., nucleic acid. The binding of the protein to the analyte and nucleic acid can be mutually exclusive, ... 12/28/06 - 20060292580 - Cleavage of nucleic acids The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a ... 12/28/06 - 20060292579 - Methods of enzymatic discrimination enhancement and surface bound double-stranded dna Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide ... 12/28/06 - 20060292578 - Dna polymerase blends and mutant dna polymerases A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5′-exonuclease activity and one of which has 5′-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis, ... 12/28/06 - 20060292577 - Neoplasia-specific splice variants and methods All neoplastic cells express a unique cell-surface ubiquinone (NADH) oxidase with protein disulfide-thiol isomerase with characteristic sensitivity to inhibition by capsaicin, sulfonylureas, adriamycin and certain other compounds. This neoplasia-specific protein is the translational expression production of a particular splice pattern: exon 4 is not translated to become part of the ... 12/28/06 - 20060292576 - Non-in situ hybridization method for detecting chromosomal abnormalities The present invention provides methods of detecting chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases. In particular, the present invention provides advanced methods of performing DNA hybridization, capture, and detection on solid support. Invention methods are useful for the detection, diagnosis, predicting response to ... 12/28/06 - 20060292575 - Novel method for diagnosing pathogens of sexually transmitted diseases The present invention provides a novel method for diagnosing various pathogens of sexually transmitted diseases from one test sample. The method comprises amplifying the DNA fragments of the various pathogens synchronously by using one primer set and identifying the amplified DNA fragments with specific probes. This invention also provides a ... 12/28/06 - 20060292574 - Automated vntr genotyping method The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PCR and high throughput MegaBACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′,4,4′,5′,7,7′-hexachlorofluorescein (HEX) labeling PCR primers. The method ... 12/28/06 - 20060292573 - Human orthologues of wart The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to ... 12/28/06 - 20060292572 - Cell-type-specific patterns of gene expression Among the methods, compositions, combinations and kits provided herein are those for determining gene expression levels in one or more cell types in heterogeneous cell samples, for identifying genes differentially expressed in different cell types, and for detecting a cell type in a sample from a subject. Also provided herein ... 12/28/06 - 20060292571 - Quantification schemes for quantifying nucleic acids Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common ... 12/28/06 - 20060292570 - Novel synthetic binding pairs and uses thereof Derivatized cucurbiturils can be efficiently prepared and utilized for forming cucurbituril assemblies. These cucurbituril assemblies, in turn, can form affinity binding pairs with polyamines structures that are designed capable of binding to these assemblies. The resulting affinity pairs are highly advantageous over the presently known affinity pairs and therefore can ... 12/28/06 - 20060292569 - Method for selectively binding a substrate to sorbents by way of at least bivalent bonds A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from ... 12/28/06 - 20060292568 - Method of preparing dna fragments and applications thereof The invention relates to a method of preparing DNA fragments and to the applications thereof, in particular for the hybridisation of nucleic acids. The inventive method is essentially characterised in that it consists of at least the following steps comprising: (a) preparation of double-stranded DNA fragments from a sample of ... 12/28/06 - 20060292567 - Method and means for determining specific conditions or changes in the uterine epithelium and in the epithelium of other organs In a method for determining specific conditions or changes in the endometrium or in the epithelium of other organs, RNA from a blood sample or tissue sample isolated and the expression or over expression of mRNA of at least one of β7-hCG, β6-hCG, and β6e-hCG is measured quantitatively in the ... 12/28/06 - 20060292566 - Method for optimising gene expressing using synonymous codon optimisation The present invention discloses a method for modulating the quality of a selected phenotype that is displayed by an organism or part thereof and that results from the expression of a polypeptide-encoding polynucleotide by replacing at least one codon of that polynucleotide with a synonymous codon that has a higher ... 12/28/06 - 20060292565 - Methods of cardiovascular disease assessment in an individual Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha-2C (α2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (β1Arg389) in a sample ... 12/28/06 - 20060292564 - Method and nucleic acids for the analysis of breast cell proliferative disorders The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of breast cell proliferative disorders, ... 12/28/06 - 20060292563 - Methods of diagnosing & treating diabetes and insulin resistance The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels ... 12/28/06 - 20060292562 - Methods of identifying genomic and proteomic biomarkers for cystic fibrosis, arrays comprising the biomarkers and methods of using the arrays Cystic fibrosis (CF) is the most common fatal autosomal recessive disease in the U.S. and is principally caused by the DF508 mutation the CFTR gene. The principal site of morbidity and mortality for this disease is the lung. We have used genomic and proteomic methods to identify ubiquitin carboxy terminal ... 12/28/06 - 20060292561 - Dna enzymes Methods for the selection of novel signaling allosteric DNA enzymes are provided. In particular, fluorescent signaling allosteric DNA enzymes are described. The selection system is based on the cleavage of an ribonucleotide flanked by a fluorophore modified nucleotide and a quencher modified oligonucleotide. Both cis-acting and trans-acting allosteric DNA enzymes ... 12/28/06 - 20060292560 - Transcription factor target gene discovery The ability to rapidly define transcription factor target genes allows for the study of genetic cascades involved in development, physiology and disease. The presently descibed invention outlines the combination of novel chromosomal immunoprecipitation and molecular biology technologies fot the high-throughput in vico discovery and characterization of both known and unknown ... 12/21/06 - 20060286599 - Open channel solid phase extraction systems and methods The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; purging bulk liquid from said extraction ... 12/21/06 - 20060286598 - Isolated cel ii endonuclease The present invention relates to the isolation and characterization of CEL I and CEL II endonuclease proteins. Methods and kits for identifying mismatches in double-stranded DNA are also provided. ... 12/21/06 - 20060286597 - Aortic carboxypeptidase-like polypeptide The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects. ... 12/21/06 - 20060286596 - Method and apparatus for separating and purifying biopolymers The present invention separates and purifies a negatively charged target biopolymer from among biological samples without involving fluid movements. In other words, a first solution containing said biological samples and a second solution for preserving a separated and purified biopolymer are partitioned by a gel, thereby allowing said target biopolymer ... 12/21/06 - 20060286595 - Methods and compositions for the detection of cervical disease Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical ... 12/21/06 - 20060286594 - Detection of antidepressant induced mania Methods and kits for assessing the susceptibility of a patient to antidepressant-induced mania are described. The method involves testing a sample from a patient for the presence of the s variant of the 5HTTLPR polymorphism in the 5HTT gene. The presence of this s variant indicates that the patient is ... 12/21/06 - 20060286593 - Transforming growth factor alpha hi The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and ... 12/21/06 - 20060286592 - Candida kefyr cytosine deaminase A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme. ... 12/21/06 - 20060286591 - Methods and compositions for expressing negative-sense viral rna in canine cells The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make ... 12/21/06 - 20060286590 - Cis-regulatory modules A process for identifying a cis-regulatory module including aligning a target sequence with at least one sequence from a moderately distant species; determining a non-coding region of the target sequence, wherein the non-coding region comprises at least one of a high level of conservation and a suppression of indels; and ... 12/21/06 - 20060286589 - Method of screening multiple single nucleotide polymorphisms associated with susceptibility to specific disease or drug response Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more ... 12/21/06 - 20060286588 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes. ... 12/21/06 - 20060286587 - Methods for quantitative analysis of a nucleic acid amplification reaction Methods for quantitating an initial amount of a target nucleic acid in a sample which has been subjected to in vitro nucleic acid amplification to produce data that is analyzed by using a Fourier Transform based algorithm are disclosed. ... 12/21/06 - 20060286586 - Method to diagnose or screen for inflammatory diseases The invention relates to the field of medical diagnostics. More specifically, the invention relates to methods to diagnose or screen for inflammatory conditions or disease, including auto-inflammatory disease and affective disorder, in a subject, preferably a human subject, by assaying for a marker for an inflammatory disease. Provided is a ... 12/21/06 - 20060286585 - Methods for diagnosing epigenetic, transgenerational effects of environmental toxicants on mammalian germ-lines and treating associated diseases The present invention provides methods for detecting epigenetic, multigenerational DNA alterations caused by toxicants such as endocrine disruptor agents in a subject. The practice of the present invention can be used to diagnose and/or treat a subject having the identified DNA alterations by developing therapeutics, to prevent or delay the ... 12/21/06 - 20060286584 - Compositions and methods for the regulation of cell proliferation and apoptosis The present invention includes compositions and methods for the detection, characterization, diagnosis and kits related to the modification of transcriptional factors of the YAP signaling pathway and their correlation with oncogenesis. ... 12/21/06 - 20060286583 - Multiplex branched-chain dna assays Methods of detecting two or more nucleic acids in a multiplex branched-chain DNA assay are provided. Different nucleic acids are captured through cooperative hybridization events on different, identifiable subsets of particles or at different selected positions on a spatially addressable solid support. Compositions, kits, and systems related to the methods ... 12/21/06 - 20060286582 - Microchip assembly Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip ... 12/21/06 - 20060286581 - Heteroconfigurational polynucleotides and methods of use Methods, compositions and kits are disclosed that utilize heteroconfigurational polynucleotide comprising a D-form polynucleotide sequence portion and an L-form polynucleotide sequence portion that is covalently linked to the D-form polynucleotide sequence portion. ... 12/21/06 - 20060286580 - Multiplexed polymerase chain reaction for genetic sequence analysis A PCR method involving: providing a biological sample suspected of containing one or more pathogen nucleic acids; adding a plurality of PCR primers corresponding to genes found in the pathogens; and performing a polymerase chain reaction on the sample to amplify a subset of the nucleic acids that correspond to ... 12/21/06 - 20060286579 - Normalization genes This invention provides gene sequence identities and methods for the determination of cellular gene expression and the comparison of expression levels between different gene sequences and between different cells. The gene sequences may be used as reference, normalization, or “housekeeping” gene sequences, the expression of which remains consistent in individual ... 12/21/06 - 20060286578 - Detection of 5t4 rna in plasma and serum This invention provides methods for detecting the presence of malignant or premalignant cells, or trophoblastic cells in a human wherein the malignant, premalignant or trophoblastic cells express 5T4. The methods of the invention detect 5T4 RNA in blood, blood plasma, serum, and other bodily fluids. The inventive methods are useful ... 12/21/06 - 20060286577 - Methods for detection of methylated dna The present invention provides methods for improving the efficiency of methylation detection. The present invention provides improvements from current technologies via increased efficiency of template denaturation and bisulfite conversion reaction, also significant time savings in sample preparation, recovery, as well as increased efficiency of desulfonation. These methods facilitate rapid analysis ... 12/21/06 - 20060286576 - Methods and nucleic acids for the analyses of cellular proliferative disorders The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for ... 12/21/06 - 20060286575 - Mcl-1 quadruplex nucleic acids and uses thereof A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer ... 12/21/06 - 20060286574 - Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases The present invention provides compositions useful in treating drug-resistant microorganisms and cells, as well as related methods of identifying and using such compositions. In addition, the present invention includes compositions useful in enhancing the sensitivity of both drug-resistant and drug-sensitive microorganisms and cells to microbicidal and cytotoxic agents, including antibiotics ... 12/21/06 - 20060286573 - Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope A nucleotide sequence of a single-stranded nucleic acid molecule immobilized on a substrate is determined with an SPM by analyzing a shape of bases constituting the single-stranded nucleic acid molecule by scanning over a nucleic acid chain of the single-stranded nucleic acid molecule immobilized on the substrate with a probe ... 12/21/06 - 20060286572 - Method for producing chemically synthesized and in vitro enzymatically synthesized nucleic acid oligomers A method is described for producing chemically synthesized and in vitro enzymatically synthesized oligomer and other nucleic acid molecules which are associated with less nucleotide sequence damage than prior art chemically synthesized and biologically synthesized oligomers and other nucleic acid molecules, along with the use of such improved oligomers and ... 12/21/06 - 20060286571 - Methods of predicting methotrexate efficacy and toxicity The present invention provides methods for analyzing genetic and/or metabolite biomarkers to individualize methotrexate (MTX) therapy. For example, the assay methods of the present invention are useful for predicting whether a patient will respond to MTX and/or has a risk of developing toxicity to MTX based upon the genotype of ... 12/21/06 - 20060286570 - Use of photopolymerization for amplification and detection of a molecular recognition event The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular ... 12/21/06 - 20060286569 - Method, apparatus, and system for authentication using labels containing nucleotide sequences A method, label, and labeling system for labeling and authenticating an item are presented. At least one of a number of known nucleotide sequences associated with a predetermined amount of information is used as a label to be associated with an item. The label is then read with a reagentless ... 12/21/06 - 20060286568 - Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a subject that is at risk or not at risk for developing spinocerebellar ataxia type 5. The present invention also provides isolated polynucleotides ... 12/21/06 - 20060286567 - Salicylamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands ... 12/21/06 - 20060286566 - Detecting apparent mutations in nucleic acid sequences A target nucleic acid sequence information obtained from a biological sample can be compared against a collection of reference nucleic acid sequences. The target nucleic acid sequence is aligned or matched against the reference sequences, wherein some of the target sequences have one or more polymorphisms. Different collections of reference ... 12/21/06 - 20060286565 - Prediction of likelihood of cancer recurrence The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer. ... 12/21/06 - 20060286564 - Modified pol iii replicases and uses thereof The invention provides Pol III α mutants, and modified Pol III replicases comprising the same, and methods of using modified Pol III replicases for a variety of nucleic acid replication reactions. ... 12/21/06 - 20060286563 - Analytical method and device utilizing magnetic materials The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of ... 12/21/06 - 20060286562 - Methods for purifying dna polymerases The present invention provides methods and kits for obtaining substantially pure DNA polymerases. The methods comprise fractionating preparations comprising at east one DNA polymerase using Poly U Sepharose chromatography and obtaining substantially pure DNA polymerase. The present invention also provides compositions comprising substantially pure archaebacterial DNA polymerase obtained by fractionation ... 12/21/06 - 20060286561 - Propargylethoxyamino nucleotides wherein R1 and R2 are —H lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is —H or —H; W2 is —H or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3′-position; and W3 is —PO4, —P2O7, —P3O10, phosphate ... 12/21/06 - 20060286560 - Surface treatment A method for producing a monolayer of molecules on a surface is described. The method includes loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, and amplifying the seed molecules via an amplifying reaction to produce the monolayer. This method permits generation of complete ... 12/21/06 - 20060286559 - Nucleic acids for detection of listeria Isolated nucleic acids and methods for detecting nucleic acid of Listeria in a test sample are provided. The isolated nucleic acids may be incorporated into polymerase chain reactions to provide for the rapid detection of Listeria in samples. ... 12/21/06 - 20060286558 - Normalization of samples for amplification reactions The present invention provides oligonucleotide primers, compositions, methods, and kits for determining the number of cells from which a cell lysate originated. The invention relies on detection and amplification of unique genomic sequences within the genome of an organism of interest to determine the amount of genomic nucleic acid in ... 12/21/06 - 20060286557 - Combined lysis and pcr buffer The present invention provides compositions, methods, and kits for lysing cells, storing nucleic acids, amplifying nucleic, and analyzing nucleic acids. Among other things, the compositions, methods, and kits are suitable for one-step lysis and amplification of nucleic acid sequences of interest. In general, the compositions comprise TCEP and a non-ionic ... 12/21/06 - 20060286556 - Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease of the central nervous system that is widely used as an animal model of multiple sclerosis (MS). In this study it was demonstrate that CXCL13, a chemokine involved in the development of secondary lymphoid tissues, is expressed in CD11c+ myeloid cells ... 12/21/06 - 20060286555 - Microarray support for bioprobe synthesis A system for conducting chemical and/or biochemical reactions is provided, comprising a reaction substrate (A) with a multiplicity of reactor zones (C), said reaction substrate (A) having a substantially flat top surface and a substantially flat bottom surface, the reaction substrate (A) being porous with a multiplicity of essentially parallel ... 12/21/06 - 20060286554 - Fluid container for electrohydrodynamic spray device and method of using same A fluid container (6) for use with an electrohydrodynamic spray device (1) and method of using the device (1) are provided. The container (6) comprises at least one reservoir configured for holding a sprayable liquid, at least one interface (23) in fluid communication with the reservoir, at least one manifold ... 12/21/06 - 20060286553 - Method for forming self-assembly substance using oligonucleotide synthesized by gene amplification reaction, self-assembly substance and method for detecting gene There is provided a method for forming a self-assembly substance using oligonucleotides without using special instruments or complicated procedures, an self-assembly substance formed by the method for forming the self-assembly substance, and a method for detecting an amplified target gene at a low cost and in a simple way by ... 12/14/06 - 20060281129 - Method for detecting biopolymers A technique is provided that easily detects biopolymers such as a DNA or a protein by utilizing semiconductor nanoparticles having different excitation wavelengths and fluorescence due to differences in particle size. By binding the semiconductor nanoparticles with avidin (or biotin), detection of biopolymers labeled with biotin (or avidin) is enabled. ... 12/14/06 - 20060281128 - Compositions and methods using lentivirus-based vectors for generating immune responses The present invention relates to multiple novel approaches for the generation of an immune response in an animal, such as a human, using lentivirus-based vector technology. The invention provides for the ability to mimic the efficacy of a live attenuated (LA) vaccine, without exposing the patient to the risk of ... 12/14/06 - 20060281127 - Promoter sequences for urocortin ii and the use thereof Various human urocortin II promoter sequences are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences. Also disclosed are methods of modulating the activity of a human urocortin II promoter sequence and methods of ... 12/14/06 - 20060281126 - Methods for monitoring the expression of alternatively spliced genes Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants. ... 12/14/06 - 20060281125 - Icbp90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell proliferation and compounds useful as medicine for preventing and/or treating pathology involving cell ... 12/14/06 - 20060281124 - Device and method for purification of biological materials An apparatus, method and kit for isolating a biomolecule from a sample. The sample comprises a complex biological material, which includes insoluble matter. Some embodiments of the apparatus and kit include a reservoir and means for capturing the biomolecule either contained within or coupled to the reservoir. The reservoir can ... 12/14/06 - 20060281123 - Polynucleotide comprising single-nucleotide polymorphism associated with colorectal cancer, microarray and diagnostic kit comprising the same, and method of diagnosing colorectal cancer using the same Provided are a polynucleotide for diagnosis or treatment of colorectal cancer including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1 and 2 and including a nucleotide at position 101 of the nucleotide sequence, or the complement ... 12/14/06 - 20060281122 - Methods for the identification, assessment, and treatment of patients with cancer therapy The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain individual and/or combinations of predictive ... 12/14/06 - 20060281121 - Computing with biomolecules The present invention is of a molecular entity comprising a polypeptide core and nucleic acid sequences attached thereto which is capable of forming a universal logic gate such as the NAND gate. Specifically, the present invention can be used to device a molecular computing unit which can be used to ... 12/14/06 - 20060281120 - Susceptibility genes for age-related maculopathy (arm) on chromosome 10q26 Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an ... 12/14/06 - 20060281119 - Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (spm) The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes may be allowed to bind to one or more target molecules. ... 12/14/06 - 20060281118 - Methods and compositions for rapid purification of proteasomes and methods of use of components thereof Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin. Also disclosed are methods for assessing aberrant cell growth utilizing fusion proteins have homology to ubiquitin and a signal producing moiety. ... 12/14/06 - 20060281117 - Alternatively spliced isoform of calcium channel, voltage dependent, alpha-1g subunit (cacna1g) The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of calcium channel, voltage dependent, alpha-1G subunit (CACNA1G). The polynucleotide sequence of CACNA1Gsv1 is provided by SEQ ID NO 4. The amino acid sequence of CACNA1Gsv1 is provided by SEQ ID NO 5. The polynucleotide sequence of ... 12/14/06 - 20060281116 - In situ heat induced antigen recovery and staining apparatus and method Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable ... 12/14/06 - 20060281115 - Max quadruplex nucleic acids and uses thereof The MAX regulatory region contains a functional quadruplex structure. Thus, provided herein are MAX quadruplex nucleic acid acids, nucleic acid therapeutics that target quadruplex-altered nucleotide sequences and methods, methods for identifying compounds that modulate the biological activity of a native MAX quadruplex DNA, and methods for modulating the biological activity ... 12/14/06 - 20060281114 - Methods and compositions for assessment of pulmonary function and disorders The present invention provides methods for the assessment of risk of developing occupational chronic obstructive pulmonary disease (OCOPD) in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing OCOPD. Nucleotide probes and primers, ... 12/14/06 - 20060281113 - Accessible polynucleotide libraries and methods of use thereof Disclosed are methods of assembling nucleic acid constructs from component parts in a manner that is not dependent on the sequence of the component parts. The methods may be used to assemble large nucleic acid constructs from multiple component parts in one or more reactions. The methods may also be ... 12/14/06 - 20060281112 - Design of capture molecules for the detection of amplicons with high sensitivity The invention relates to a method for the design and/or the preparation of a polynucleotide capture molecule for detecting an amplicon having one strand serving as target to be detected and/or quantified after hybridization on said capture molecule, comprising the steps of: (a) selecting a primer pair defining the amplicon; ... 12/14/06 - 20060281111 - Kinase peptides and antibodies The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as for determining or monitoring the efficacy of treatment. ... 12/14/06 - 20060281110 - Methods to identify antimicrobial compounds that interrupt ribosome biogenesis The present invention discloses that essential and highly conserved GTPases (i.e., for example, YlqF, YqeH, YsxC, or YphC proteins) from Bacillus subtilis participate in ribosome biogenesis. Before this invention, the biological function of the GTPase proteins were unknown. These GTPase proteins are disclosed to affect translation and believed to promote ... 12/14/06 - 20060281109 - Polymerases Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The ... 12/14/06 - 20060281108 - Compositions and methods for the analysis of degraded nucleic acids The invention relates to compositions and methods for gene expression analysis. In some embodiments, the invention provides compositions and methods for amplifying targets in a degraded nucleic acid sample. In some embodiments, the invention provides methods for determining the quality of nucleic acids (e.g., the degree of degradation) in a ... 12/14/06 - 20060281107 - Acute myelogenous leukemia biomarkers The present invention provides novel compositions and their use in classifying acute myelogenous leukemia. ... 12/14/06 - 20060281106 - Telomerase promoter sequences for screening telomerase modulators Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote ... 12/14/06 - 20060281105 - High throughput multiplex dna sequence amplifications The present invention provides methods of designing PCR primers that allow the efficient and simultaneous amplification of a large number of different desired DNA fragments in a single multiplex PCR and minimize the formation of nonspecific extensions of undesired DNA fragments. The present invention allows a multiplex PCR to use ... 12/14/06 - 20060281104 - Leuco dye particles and uses thereof The invention provides methods and compositions for detecting the presence of, or for measuring amounts of, molecular targets, particularly molecular complexes comprising two or more proteins, such as receptor complexes of cell surface membranes. In one aspect of the invention, reagent pairs are provided that comprise a reactive species generator ... 12/14/06 - 20060281103 - Increased sensitivity of nucleic acid-based detection of organisms by fractionation of target genomes A method of analyzing a sample for detection of presence or absence of an organism of interest in the sample comprising (a) obtaining a sample; (b) subjecting the sample to a disruption treatment sufficient to fractionate any nucleic acid sequences present in the sample; and (c) detecting for presence or ... 12/14/06 - 20060281102 - Methods for detecting genetic haplotypes by interaction with probes The present invention provides methods for determining genetic haplotype comprising identifying target nucleic acids or gene fragments, said nucleic acids or gene fragments comprising a haplotype of interest, and detecting at least one parameter displayed by one of a primer-dependent transcript, a probe, or a primer-dependent transcript/probe complex. Further provided ... 12/14/06 - 20060281101 - Biobriefcase A bio-briefcase system for analyzing a sample for the presence of biological agents. The bio-briefcase system comprises a housing, an immunoassay section operatively connected to the housing, and/or a nucleic acid assay section operatively connected to the housing. ... 12/14/06 - 20060281100 - Thiotriphosphate nucleotide dye terminators Fluorescent reporter compounds having a chain terminating (thio)triphosphate nucleotide derivative, a fluorescent dye, and a linker of sufficient length to connect the nucleotide derivative to the fluorescent dye are provided. The fluorescent reporter compounds are used in DNA sequencing reactions and are substantially inactive toward exonuclease digestion. ... 12/14/06 - 20060281099 - Q-melt for polymorphism detection The invention provides a new method of determining the presence of one or more polymorphic sites in a target nucleic acid sequence. The method comprises determining changes in the melting profile of an amplified product where the amplified product was amplified with a primer pair where one of the primers ... 12/14/06 - 20060281098 - Method and kits for multiplex hybridization assays The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is ... 12/14/06 - 20060281097 - Method of processing and/or genome mapping of ditag sequences Method of processing and/or genome mapping of ditag sequences There is provided a method and system for processing and/or mapping ditag nucleotide sequence(s) to a genome, the ditag sequence comprising the 5′ terminal tag and the 3′ terminal tag of a nucleic acid molecule or fragment thereof or genomic fragment. ... 12/14/06 - 20060281096 - Methods and kits for detecting genetically modified organism (gmo) This invention provides a method for detecting genetically modified organism (GMO) comprising amplifying transgenes of GMO by biotin-labeled primer sets, hybridizing the amplified products with colored bead-labeled probes, and detecting the hybrids. This invention also provides a polynucleotide for detecting a transgene of genetically modified soybean. This invention further provides ... 12/14/06 - 20060281095 - 44 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing ... 12/14/06 - 20060281094 - Apparatus for processing a fluid sample This invention relates to an apparatus for processing a fluid sample comprising: (i) a platform comprising: (a) a chamber suitable for receiving a sample; and (b) a functional component; (ii) an arm capable of being raised and lowered and including a means for removeably attaching to the functional component such ... 12/14/06 - 20060281093 - Erbb receptor methods and kits for monitoring chemotherapy resistance The present invention relates to monitoring of ErbB receptor levels in methods and kits for determining the prognosis of cancer in a subject or improving the effectiveness of a cancer treatment. The invention also provides a method for predicting the recurrence of clinical signs of a cancer in a subject. ... 12/14/06 - 20060281092 - Method for the reverse transcription and/or amplification of nucleic acids The present invention relates to a process for the reverse transcription and/or amplification of a product from a reverse transcription of a pool of nucleic acids of a specific type, this pool of nucleic acids originating from a complex biological sample or an enzymatic reaction. ... 12/14/06 - 20060281091 - Genes regulated in ovarian cancer a s prognostic and therapeutic targets This invention relates to the use of genomic analysis to detect the presence of ovarian cancer in a patient from a sample of tissue or blood and to kits for carrying out this determination. In addition this invention relates to methods to treat a patient with ovarian cancer. ... 12/14/06 - 20060281090 - Capsid-modified adenovirus vectors and methods of using the same Adenovirus fiber mutated in the regions involved in the recognition and the binding of blood factor proteins, and adenoviruses comprising such fibers are provided. ... 12/14/06 - 20060281089 - Methods for detecting cancer and monitoring cancer progression Mutant BNIP3 plays a functionally important role in the development of solid tumors and in resistance to chemotherapy and radiation treatments. The invention relates to methods of detecting cancer, methods of monitoring the progression of cancer, methods of identifying patients with cancer that is resistant to chemotherapy or radiation treatments, ... 12/14/06 - 20060281088 - Markers for lxr activation The present invention relates to surrogate markers for LXR activation, and methods of diagnosing a disease linked to LXR activation, methods of monitoring the treatment of patients suffering from a disease linked to LXR activation, and methods of identifying compounds which modulate LXR activity. ... 12/14/06 - 20060281087 - Titanium dioxide complex having molecule distinguishability A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule ... 12/14/06 - 20060281086 - Recovery of dna The invention provides a method for recovery of cDNA from mRNA, comprising reverse transcription (RT) of mRNA using a RT primer which includes a sequence based on the 5′ consensus region of the mRNA which is identical or similar to 5′ consensus region of the mRNA and which includes a ... 12/14/06 - 20060281085 - Diagnostics and therapeutics for diseases associated with phosphodiesterase 1b (pde1b) The invention provides a human PDE1B which is associated with the cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, metabolic ... 12/14/06 - 20060281084 - Method of detecting bifidobacterium infantis PCR primers for detecting Bifidobacterium infantis comprising: a pair of a first oligonucleotide having a sequence of 20 or more continuous nucleotides selected from a nucleotide sequence of SEQ ID NO: 1 and a second oligonucleotide having a nucleotide sequence of SEQ ID NO: 2 or a nucleotide sequence of ... 12/14/06 - 20060281083 - Identification of genes involved in angiogenesis, and development of an angiogenesis diagnostic chip to identify patients with impaired angiogenesis The invention is directed to methods for angiotyping individual patients to predict the likelihood of whether a given individual will develop good vs. poor collaterals naturally. Accordingly, this can involve obtaining and providing a list of genes involved in collateral development. In particular, angiotyping individual patients can be used to ... 12/14/06 - 20060281082 - Genome partitioning This invention relates to ‘genome partitioning’ and nucleic library construction, for example for sequence variation discovery and screening. The method employs a plurality of restriction enzymes in order to reliably reproduce a representative partition of the entirety of a sample nucleic acid based on the restriction ends of one or ... 12/14/06 - 20060281081 - Method of diagnosing colon and gastric cancers Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer—associated gene that discriminate between colon or gastric cancer and nomal cell. The present invention further provides methods of screening for ... 12/14/06 - 20060281080 - Novel lipases and uses thereof The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel lipolytic enzyme from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprising the full length coding sequence of the novel lipolytic enzyme as well as ... 12/14/06 - 20060281079 - Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element The present invention relates to a method of preparing a cDNA molecule which includes: contacting an RNA molecule, in the presence of dNTPs, with a non-LTR retrotransposon protein or polypeptide having reverse transcriptase activity under conditions effective for production of a cDNA molecule complementary to the RNA molecule, said contacting ... 12/14/06 - 20060281078 - Human fast-1 gene hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-β receptor. The hFAST-1 protein binds to a novel ... 12/07/06 - 20060275820 - Multiplex flow assays preferably with magnetic particles as solid phase Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit ... 12/07/06 - 20060275819 - Guanylate-binding protein A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly. ... 12/07/06 - 20060275818 - Method of producing probe arrays for biological materials using fine particles The use of probe arrays in which probes of various biological substances such as DNA are immobilized on the surface of a solid is becoming established as an effective means for high-speed screening. Different kinds of probes, such as DNA, are immobilized on the surface of a multiple number of ... 12/07/06 - 20060275817 - Sequencing by incorporation Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by ... 12/07/06 - 20060275816 - Methods for identifying drug pharmacology and toxicology The invention combines a microarray and cell-based screening strategy that enables rapid identification of possible mechanisms underpinning the pharmacology and toxicology of drug candidates. The methods of the invention identified unique properties relating to apoptosis and the anti-inflammatory response elicited by several peroxisome proliferator activated receptor gamma (PPARγ) ligands. The ... 12/07/06 - 20060275815 - Method of and apparatus for the purification of nucleic acids using immobilized metal-ligand complex Provided is a method of purifying nucleic acids using a metal-ligand complex, the method comprising: immobilizing the metal-ligand complex on a solid support; bringing a sample containing the nucleic acid into contact with the immobilized complex on the solid support to bind the nucleic acid to the complex; and adding ... 12/07/06 - 20060275814 - Probes and methods for identifying polycyclic aromatic hydrocarbon-degrading mycobacteria A method for determining whether a microorganism is capable of biodegrading a contaminant can include the following: providing a first set of DNA molecules consisting of fragments of genomic DNA of a contaminant-degrading mycobacterium; contacting under hybridizing conditions, the first set of DNA molecules with a second set of DNA ... 12/07/06 - 20060275813 - Cartridge for chemical reaction The cartridge for chemical reaction according to the invention is a cartridge for chemical reaction that causes chemical reaction by feeding an internal liquid by way of deformation caused by external forces. The entirety of a target molecule detecting chip is housed in the cartridge for chemical reaction. According to ... 12/07/06 - 20060275812 - Assay for agonists and antagonists of ion channels and for regulators of genetic expression The invention provides an assay for agonists and antagonists of ion channels and for regulators of genetic expression. ... 12/07/06 - 20060275811 - Method for producing target substance capturing protein and method for selecting component materials thereof A combination of polypeptide chains used as a plurality of target substance-binding domains are selected by: (1) reacting a target substance with a first polypeptide chain with a known target substance-binding domain to obtain a first complex; (2) reacting the first complex with a second polypeptide chain library composed of ... 12/07/06 - 20060275810 - Focused microarray and methods of diagnosing chemotherapeutic drug resistance in a cancer cell Disclosed are methods for diagnosing chemotherapeutic drug resistance in a cancer cell sample by detecting an increase in the levels of expression of marker genes in the cancer cell sample as compared to the levels of expression of the same marker genes in a chemotherapeutic drug-sensitive cancer cell of the ... 12/07/06 - 20060275809 - Rapid identification of the varieties and genotypes of cryptococcus neoformans species complex using a high-throughput flow cytometer Nucleic acid probes and molecular method to identify the varieties and genotypic groups within C. neoformans species complex. The method employs a flow cytometer with a dual laser system that allows the simultaneous detection of different target sequences in a multiplex and high-throughput format. The assay uses a liquid suspension ... 12/07/06 - 20060275808 - Methods of analysis of polymorphisms and uses thereof The present invention provides methods for the assessment of diseases that result from the combined or interactive effects of two or more genetic variants, and in particular for diagnosing risk of developing such diseases in subjects using an analysis of genetic polymorphisms. Methods for the derivation of a net score ... 12/07/06 - 20060275807 - Novel steroid 5alpha-reductase The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a ... 12/07/06 - 20060275806 - Whole genome methylation profiles via single molecule analysis Methods for determining methylation profiles of single polynucleotide molecules, especially genomic DNA molecules, by using sequence specificity and methylation sensitivity of restriction endonucleases and other proteins that selectively bind to methylated or unmethylated residues. ... 12/07/06 - 20060275805 - System, method, and computer product for exon array analysis In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, ... 12/07/06 - 20060275804 - Enzymes having dehalogenase activity and methods of use thereof The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature. ... 12/07/06 - 20060275803 - Rat and mouse members of the crisp family of genes Disclosed herein are nucleic acid and polypeptide sequences of the mouse and rat homologues of human cysteine-rich secretory protein-1. Also disclosed herein are methods related to the use of the aforementioned mouse and rat homologues. ... 12/07/06 - 20060275802 - Mutations in oas1 genes Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided. ... 12/07/06 - 20060275801 - Methods for detection of biological substances The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological substance is not related to a respiratory disease. The invention also provides treatment of the diseases following the detection of ... 12/07/06 - 20060275800 - Process for characterization of the transactivation and transrepression activity of glucocorticoid receptor ligands in primary immune cells The invention relates to a process for the characterization of the transactivation and transrepression activity of glucocorticoid receptor (GR) ligands by gene and/or protein expression analysis in primary immune cells as well as the use thereof. ... 12/07/06 - 20060275799 - Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5′-end, (or possibly at the 3′ end) to an encoded ... 12/07/06 - 20060275798 - Detection of organisms using a media sachet and primer directed nucleic acid amplification A method of detecting a target organism in a sample mixture comprising preparing at least one complex sample mixture, performing primer directed nucleic acid amplification of the complex sample mixture; and examining the primer directed nucleic acid amplification result to detect for presence or absence of amplification product of the ... 12/07/06 - 20060275797 - Use of agents which inhibit connective tissue growth factor (ctgf) binding and signaling via the trka/p75ntr receptor complex for the prevention and treatment of ctgf-mediated ocular disorders The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one agent that inhibits binding and/or signaling of connective tissue growth factor (CTGF) via the TrkA/p75NTR receptor complex. ... 12/07/06 - 20060275796 - Canine herpesvirus thymidine kinase nucleic acid molecules The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic ... 12/07/06 - 20060275795 - Determination and potential control of pathogenic bacteria or bacterial strains The present invention is directed to methods to detect and/or determine bacterial pathogenicity and species identity based on genes that encode transcriptional regulators or putative transcriptional regulators. ... 12/07/06 - 20060275794 - Collections of matched biological reagents and methods for identifying matched reagents Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods ... 12/07/06 - 20060275793 - Association between markers in the leptin gene and carcass traits in commercial feedlot steer and heifers The invention provides a method for sub grouping animals according to genotype wherein the animals of each sub-group have a similar polymorphism or combination of polymorphisms in the leptin gene, the single nucleotide polymorphisms being selected from the group consisting of UASMS1, UASMS2, UASMS3, EXON2-FB, and E2JW. The combination of ... 12/07/06 - 20060275792 - Enhancement of nucleic acid amplification using double-stranded dna binding proteins Disclosed are methods and materials for enhancing the efficiency, specificity and/or specificity of nucleic acid amplification reactions (e.g., PCR amplification reactions). The disclosed inventions involve the use of nonspecific double-stranded DNA binding proteins in amplification reactions. The methods described herein are useful in a wide variety of molecular biology applications ... 12/07/06 - 20060275791 - Biological control of nanoparticle nucleation, shape and crystal phase The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds ... 12/07/06 - 20060275790 - Kcnq5, a novel potassium channel The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5. ... 12/07/06 - 20060275789 - Direct multiplex characterization of genomic dna The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified. ... 12/07/06 - 20060275788 - Method for rapid detection and identification of bioagents Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. ... 12/07/06 - 20060275787 - Compositions and methods for array-based genomic nucleic acid analysis of biological molecules The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2 , wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to ... 12/07/06 - 20060275786 - Electrochemical detection of dna binding In one aspect, the invention provides methods and apparatus for detecting a protein binding to a nucleic acid by measuring the impedence of a nucleic acid layer on an electrode, for example by AC impedance spectroscopy. In one embodiment, such methods may for example be used to detect a mismatch ... 12/07/06 - 20060275785 - Species-specific primer sets and identification of species-specific dna sequences using genome fragment enrichment Targeted sequencing of genetic regions that differ between two DNA preparations uses genomic fragment enrichment. This method can be used to study genetic variation among closely related species and microbial communities. ... 12/07/06 - 20060275784 - Detection of human papilloma virus in papanicolaou (pap) smears Methods and reagents for detecting high-risk human papilloma virus (HPV) DNA types in cells on a Pap smear which indicates the patient is at higher risk for cancer are described. The method differentiates high-risk from low-risk HPV DNA in cells, which indicates the patient's risk for cancer. ... 12/07/06 - 20060275783 - Gene markers for lung cancer A method for the diagnosis and identification of new or residual lung cancer is disclosed which uses newly identified markers for lung cancer including syndecan 1, collagen 1 alpha 2, and two novel proteins, 7013 and 7018. The method involves identification of the lung cancer markers is blood from a ... 12/07/06 - 20060275782 - Detection of nucleic acid reactions on bead arrays The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide ... 12/07/06 - 20060275781 - Novel method for the protection and purification of adenoviral vectors The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions. ... 12/07/06 - 20060275780 - Cross-linking reagents and uses thereof A method of cross-linking a polynucleotide to a target compound. The method comprises (1) providing a polynucleotide and a target compound, and (2) contacting the polynucleotide and the target compound with a photoreactive cross-linking agent under conditions that allow cross-linking of the polynucleotide to the target compound. Also disclosed is ... 12/07/06 - 20060275779 - Method and apparatus for molecular analysis using nanowires Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous ... 12/07/06 - 20060275778 - Method and apparatus for molecular analysis using nanoelectronic circuits Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned ... 12/07/06 - 20060275777 - Novel strategies for protein vaccines A prerequisite for clinical vaccines is the construction of safe and highly immunogenic reagents able to generate efficient immune responses against target antigens. Lipid based delivery vesicles, including virosomes, as clinically approved safe vaccines, can be used to elicit both humoral and cell-mediated responses against protein antigens and mediate effective ... 12/07/06 - 20060275776 - Rabies vaccine The invention provides for an immunogenic rabies vaccine comprising a reduced vaccine dose and methods of pre- and post-exposure immunization with a reduced dose. The concentration of rabies vaccine antigen per dose is preferably less than 2.5 IU/mL. ... 12/07/06 - 20060275775 - Intramolecularly-quenched near infrared fluorescent probes An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation ... 12/07/06 - 20060275774 - Negative strand rna virus replicon The present invention relates to non-cytopathic negative-strand RNA virus replicons, and methods of making and using the replicons and replicon systems. ... 12/07/06 - 20060275773 - Nucleic acid processing methods, kits and devices Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processing by dilution of such agent to a concentration below 0.05 M without physical isolation of RNA and DNA ... 12/07/06 - 20060275772 - Method of detecting pancreatic islet amyloid protein mutant gene and nucleic acid probe and kit therefor A melting curve analysis is performed for a nucleic acid containing a mutation in a nucleotide sequence resulting in a mutation replacing serine at position 20 in an amino acid sequence of the pancreatic islet amyloid polypeptide with glycine (IAPP S20G), by using a nucleic acid probe of which end ... 12/07/06 - 20060275771 - Quantitative reagent, method and equipment of substance utilizing fluorescence lifetime A method of detecting a fluorescent molecule in a test sample, the following steps: (a) a step of measuring in a time-dependent manner individual fluorescence intensities of a plurality of species of fluorescent molecules each having an inherent fluorescence lifetime; and (b) a step of comparing the measured fluorescence intensities. ... 12/07/06 - 20060275770 - Heart failure gene determination and therapeutic screening Genes implicated in the progression of heart failure and in the endogenous myocardial recovery and repair mechanism provide the basis for screening potential therapeutic compounds for use as pharmaceutical preparations for the treatment of congestive heart failure. Target genes or target gene products whose expression level or biological activity are ... 12/07/06 - 20060275769 - Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases The present invention uses gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the Kaposi's sarcoma-associated ... 12/07/06 - 20060275768 - Multiplex polymer ligation The invention concerns a multiplex polymer ligation method involving water-soluble polymeric protecting groups, compositions and methods of use. The method involves synthesis of a first compound bearing one or more water-soluble polymeric protecting groups followed by replacing one or more of the water-soluble protecting groups with a chemical adduct of ... 12/07/06 - 20060275767 - Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases and nucleotide sequences encoding such kinase sequences The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The ... 12/07/06 - 20060275766 - Method for manufacturing recombinant polyclonal proteins The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing ... 12/07/06 - 20060275765 - G-proteins Gαq-Gustducin chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses. ... 12/07/06 - 20060275764 - Method for determining predisposition to manifestation of immune system related diseases The present invention relates to methods for determining predisposition to a manifestation of immune system related diseases, in particular infections, associated with a mutation in the human MASP-2 gene. The invention also features oligonucleotides, polypeptides, peptide fragments and antibodies which are used in the above methods as well as for ... 12/07/06 - 20060275763 - Porcine polymorphisms and methods for detecting them Identification of a pig as resistant or non-resistant to enterotoxigenic E. Coli (EIEC). Particularly, there is provided methods, probes and DNA molecules involved in identifying a pig as resistant or non-resistant to ETEC. There is also provided methods for breeding pigs using the information of resistance/non-resistance, mixed boar semen, and ... 12/07/06 - 20060275762 - Method of detecting target base sequence of rna interference, method of designing polynucleotide base sequence causing rna interference, method of constructing double-stranded polynucleotide, method of regulating gene expression, base sequence processing In the present invention, a sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene of RNA interference and, based on the search results, siRNA capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, ... 12/07/06 - 20060275761 - Tryptophan hydroxylase assay The present invention relates to methods of evaluation and detection of the expression of tryptophan hydroxylase (TPH) gene and induction of TPH by estrogen receptor-beta (ERβ) agonists, utilizing TPH riboprobe and/or primers. ... 12/07/06 - 20060275760 - Method for screening of a lipase having improved enzymatic activity using yeast surface display vector and the lipase The present invention relates to a method for screening of the lipase having improved enzymatic activity using yeast surface display vector and the mutant lipase prepared by the same, more particularly to the method comprising; 1) cloning lipase gene into surface display vector, 2) preparing mutant lipase gene library of ... 12/07/06 - 20060275759 - Neuronally expressed tryptophane hydroxylase and its use The present invention relates to novel, specifically neuronal expressed proteins with tryptophane hydroxylase activity, nucleic acid sequences, recombinant nucleic acid molecules containing these nucleic acid sequences or vectors containing these nucleic acid sequences or the recombinant nucleic acid molecules encoding for a neuronal tryptophane hydroxylase. The invention also relates to ... 12/07/06 - 20060275758 - Use of pp2a phosphatase modulators in the treatment of mental disorders The invention relates to the use of PP2A/Bγ and to the use of a PP2A phosphatase comprising the PP2A/Bγ subunit for screening for modulators thereof. The use of these modulators for treating mental disorders such as bipolar disorder, schizophrenia and depression, and drugs comprising these modulators are further disclosed. The ... 12/07/06 - 20060275757 - Magnetic nanomaterials and methods for detection of biological materials Biological material in a sample is reacted with a novel functionalized superparamagnetic Fe/Au nanoparticle that specifically binds to the biological material in solution to produce a magnetic particle/biological material complex. The biological material is detected upon application of an external magnetic field which separates the magnetic bound complex from other ... 12/07/06 - 20060275756 - Displacement assay for detecting ligate-ligand association events Described is a method for detection of ligate-ligand association events, the method comprising the steps: providing a modified surface, the modification consisting in the attachment of at least one type of ligate; providing signal ligands; providing a sample having ligands; bringing a defined quantity of the signal ligands into contact ... 12/07/06 - 20060275755 - Novel nucleic acids and polypeptides related to a guanine exchange factor of rho gtpase The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates ... 11/30/06 - 20060269962 - Multiplex flow assays preferably with magnetic particles as solid phase Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit ... 11/30/06 - 20060269961 - Dendrimer-based dna extraction methods and biochips The present invention provides a dendrimer-based biochip, wherein a flow channel through which a solution containing biopolymer molecules is flowed is formed in the substrate of the biochip, a plurality of dendrimer molecules one end of each of which is bound to the walls of the flow channel are formed ... 11/30/06 - 20060269960 - Isolated peptides corresponding to amino acid requirements of ny-eso-1, which bind to mhc class i and mhc class ii molecules, and uses thereof The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. ... 11/30/06 - 20060269959 - Sequences of an ih ion channel and use thereof The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated ... 11/30/06 - 20060269958 - Uv excitable energy transfer reagents Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One ... 11/30/06 - 20060269957 - Secreted proteins and polynucleotides encoding them Novel polynucleotides and the proteins encoded thereby are disclosed. ... 11/30/06 - 20060269956 - Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571 The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind ... 11/30/06 - 20060269955 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and ... 11/30/06 - 20060269954 - Self-assembling recombinant papillomavirus capsid proteins Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, ... 11/30/06 - 20060269953 - Novel hepatitis b virus We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab. ... 11/30/06 - 20060269952 - Genotyping method using distance measure A genotyping method includes: (a) hybridizing a known standard nucleic acid to a DNA chip on which an optimal probe set composed of two or more different probes matching respective two or more different genotypes is immobilized for each mutation site, calculating an input vector having two components from the ... 11/30/06 - 20060269951 - Inhibitors of autoinducer transporters The present invention relates to the discovery of the lsr operon, the genes therein, and the polypeptides encoded by these genes. The present invention also includes strains with altered expression levels of the polypeptides encoded by the genes and the lsr operon relative to wild type cells. In some embodiments, ... 11/30/06 - 20060269950 - Method of identifying compounds that modulate interaction of androgen receptor with beta-catenin Methods for determining if test compounds are able to modulate the interaction between androgen receptor and β-catenin are disclosed. Methods for the determining whether a test compound selectively modulates an androgen receptor signaling pathway over a β-catenin-Wnt signaling pathway or a β-catenin-Wnt signaling pathway over an androgen receptor signaling pathway ... 11/30/06 - 20060269949 - Tissue rejection This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. ... 11/30/06 - 20060269948 - Tissue rejection This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. ... 11/30/06 - 20060269947 - Baselining amplification data Methods, apparatus, and systems are provided for processing a data set representing an amplification curve having a baseline portion and a growth portion. Peak objects are generated by taking a derivative of the data set. The first peak object having a value greater than a threshold is identified. An end ... 11/30/06 - 20060269946 - Methods and compositions for assessment of pulmonary function and disorders The present invention provides methods for the assessment of risk of developing chronic obstructive pulmonary disease (COPD), emphysema or both COPD and emphysema in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing ... 11/30/06 - 20060269945 - Constellation mapping and uses thereof The present invention features computer methods and systems for comparing biomolecules across biological samples. In these methods, mass spectrometry measurements are obtained on biomolecules in two or more samples. These measurements are then processed and analyzed by the methods described herein to render them more comparable. We refer to this ... 11/30/06 - 20060269944 - Mass intensity profiling system and uses thereof The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled ... 11/30/06 - 20060269943 - Linear amplification of short nucleic acids The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro RNAs by using temperature cycling during a reverse transcription reaction. The cycling can comprise at least 20 cycles of an annealing temperature segment ... 11/30/06 - 20060269942 - In situ click chemistry method for screening high affinity molecular imaging probes The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the ... 11/30/06 - 20060269941 - Single tube multiplex assay for detection of adulterants in basmati rice samples The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties. The present invention also provides a kit for performing a muliplex ... 11/30/06 - 20060269940 - Normalized nucleic acid libraries and methods of production thereof The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules ... 11/30/06 - 20060269939 - Method for conversion of a dna sequence to a number string and applications thereof in the field of accelerated drug design The present invention relates to a method for the conversion of a DNA sequence into a number string. More particularly, the present invention relates to a method for the conversion of a DNA sequence into a number string using a genomic numbering system in order to extract and/or analyze biological ... 11/30/06 - 20060269938 - Polynucleotides encoding insect plasma membrane ca2+ atpase and uses thereof The instant invention provides isolated nucleic acids encoding insect plasma membrane calcium ATPase (PMCA), as well as PMCA polypeptides encoded thereby. The invention further provides methods of identifying agents that modulate a level of PMCA MRNA, polypeptide, or PMCA activity. Such agents are candidate insecticidal compounds. ... 11/30/06 - 20060269937 - Assay for methylation in the gst-pi gene A diagnostic or prognostic assay is disclosed for a disease of condition characterized by abnormal methylation of cytosine at side or sites within the glutathione-S-transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g., prostate cancer and liver cancer). The assay comprises: (i) isolating DNA from said subject, and (ii) ... 11/30/06 - 20060269936 - Screening assay for tlr7, tlr8 and tlr9 agonists and antagonists The present invention relates to novel screening methods for identifying agonists and antagonists of toll-like receptor (TLR) 7, TLR8 or TLR9. Methods are disclosed for identifying agonists and antagonists of TLR7, TLR8 or TLR9 using mutant TLR proteins containing deletions in one or more extracellular leucine rich regions (LRRs). Such ... 11/30/06 - 20060269935 - Genetic predictor for clinical use of drugs used in the treatment of neurological conditions A method for determining the dosage regime of a drug suitable for use in the treatment of a neurological condition in a subject, which method comprises typing the SCN1A gene of the subject. The method may be used to determine the dosage regime of an anti-epileptic drug (AED) in a ... 11/30/06 - 20060269934 - Compositions and methods for clonal amplification and analysis of polynucleotides Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides. ... 11/30/06 - 20060269933 - Base sequence for control probe and method of designing the same There are provided a sequence for a control probe having a sequence rarely forming a secondary structure and rarely hybridizing with an undesired target and a method of designing thereof. There is further provided a probe carrier employing a control probe designed by the designing method. To provide these, a ... 11/30/06 - 20060269932 - Compositions and methods for polynucleotide amplification and detection Described are characteristics rendering DNA polymerases well suited for single target and multiplex genetic profiling methods, and polymerases having these characteristics. Also described are methods of single target and multiplex analyses using polymerases having the described characteristics. ... 11/30/06 - 20060269931 - Purine based fluorescent dyes The present invention provides novel purine-based fluorescent dyes that may be used for staining, localizing and otherwise labeling target molecules, such as nucleic acids, for detection, amplification and quantification. ... 11/30/06 - 20060269930 - Evanescent wave sensor with attached ligand The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a NCYX linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacting a first reactive moiety which has an isocyanato (or ... 11/30/06 - 20060269929 - Methods and kits for dna purification on polymeric membranes at low ionic strength This invention relates to methods and kits for collecting DNA from nucleic acid capture materials such as polymeric membranes at low ionic strength. The methods and kits can be used to obtain DNA for use in subsequent procedures, such as amplification and labeling reactions while reducing the co-purification of contaminants. ... 11/30/06 - 20060269928 - Compositions, methods and apparatus for supercritical fluid virus inactivation The present invention is directed to a composition of critical, supercritical or near critical fluid and apparatus for inactivating viruses associated or potentially associated with protein derived samples and methods of their use. ... 11/30/06 - 20060269927 - Nanoscale sensors Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, ... 11/30/06 - 20060269926 - Novel dyes for the detection or quantification of desirable target molecules The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides ... 11/30/06 - 20060269925 - Methods for determining glutathione s-transferase theta-1 genotype The invention relates to methods for determining GSTT1genotype, and the diagnostic and prognostic uses of these methods. ... 11/30/06 - 20060269924 - Modulation of telomere-initiated cell signaling The use of modulators of Mre 11, tankyrase, the DNA damage pathway and MRN complex formation of the protection of mammals from failure of growth arrest, apoptosis or proliferative senescence. ... 11/30/06 - 20060269923 - Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-fungal agents The present invention relates to a method for screening and identifying compounds that modulate the activity of a fungal tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit or reduce the activity of a fungal tRNA splicing endonuclease. The methods of the present ... 11/30/06 - 20060269922 - System for multi color real time pcr The invention is directed to a system for performing multi-color real time PCT, comprising a flexible real time PCT instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composition or reaction mixtuer which comprises at least 3, preferably ... 11/30/06 - 20060269921 - Methods of diagnosis and prognosis of pancreatic cancer The present invention provides novel genes and proteins for diagnosing pancreatic cancer and/or a likelihood for survival e.g., following surgical resection, wherein the expression of the genes and proteins is up-regulated or down-regulated. The pancreatic cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins ... 11/30/06 - 20060269920 - Method for obtaining structural information about an encoded molecule Disclosed is a method for obtaining structural information about an encoded molecule, wherein the encoded molecule has been produced by a process comprising reacting a plurality of chemical entities, said chemical entities being coded for by codons on a nucleic acid template. The method comprises the steps of providing an ... 11/30/06 - 20060269919 - Method of diagnosis of obesity The invention relates to new methods of diagnosis and therapy of obesity, in particular morbid obesity, based on the identification of polymorphisms in the 5′ region of the gad2 gene. ... 11/30/06 - 20060269918 - Compositions, splice variants and methods relating to colon specific genes and proteins The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of ... 11/30/06 - 20060269917 - Compositions, splice variants and methods relating to colon specific gene and proteins The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of ... 11/30/06 - 20060269916 - Probes The present invention relates to probes, methods and apparatus for the detection of the presence or absence of non-contiguous cis-located nucleic acid sequences which are characteristic of alleles including those relating to the human leukocyte antigen (HLA) which is of interest in the field of human transplantation and disease. ... 11/30/06 - 20060269915 - Pyrophosphate acid detection sensor, method of detection of nucleic acid, and method of discrimination of base type The present invention is a pyrophosphate detection sensor for detecting pyrophosphate in a sample solution, and the sensor is constituted to have a sample solution receptive part that receives the sample solution, a H+ impermeable membrane having H+-pyrophosphatase, an immobilizing layer for immobilizing the H+ impermeable membrane, and a measurement ... 11/30/06 - 20060269914 - Quantitative test for bacterial pathogens The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic ... 11/30/06 - 20060269913 - Methods of producing dna and protein libraries The present invention provides a method of producing a DNA library comprising a plurality of DNA sequences of interest, where each DNA sequence of interest has at least two predetermined positions, with at each predetermined position a codon (MAX) selected from a defined group for that position, the codons within ... 11/30/06 - 20060269912 - Compositions and methods for the detection, diagnosis and therapy of hematological malignancies Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an ... 11/23/06 - 20060263823 - Detection rpob sequences of mycobacterium tuberculosis A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by ... 11/23/06 - 20060263822 - Detection of rpob sequences of mycobacterium tuberculosis A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by ... 11/23/06 - 20060263821 - In vitro model for priocidal activity A proteinaceous material has been found to show similar activity and treatment response to that of disease causing prions, such as CJD. A prion model which incorporates the proteinaceous material has a variety of applications. The model has an ability to be cultured either in vivo or in vitro, allowing ... 11/23/06 - 20060263820 - Delivery of disease control in aquaculture and agriculture using microbes containing bioactive proteins A microbial biomass, made from algae, bacteria, fungi, yeast, or combinations thereof, provides a feed for animals raised either in agriculture or aquaculture. A feed additive, and a therapeutic composition can also be made from a microbial biomass of algae, bacteria, fungi, yeast, or combinations thereof. The feed, feed additive, ... 11/23/06 - 20060263819 - Diagnostics and therapeutics for macular degeneration-related disorders The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders. ... 11/23/06 - 20060263818 - High throughput multi-antigen microfluidic fluorescence immunoassays The development of a high-throughput multi-antigen microfluidic fluorescence immunoassay system is illustrated in a 100-chamber PDMS (polydimethylsiloxane) chip which performs up to 5 tests for each of 10 samples. Specificity of detection is demonstrated and calibration curves produced for C-Reactive Protein (CRP), Prostate Specific Antigen (PSA), ferritin, and Vascular Endothelial ... 11/23/06 - 20060263817 - Genetic polymorphism associated with myocardial infarction and uses thereof A genetic polymorphism associated with myocardial infarction is provided. More particularly, a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a complementary polynucleotide of the nucleotide sequences, a polynucleotide hybridized with one of the polynucleotides, a polypeptide encoded by one of the polynucleotides, an antibody bound to ... 11/23/06 - 20060263816 - Compounds and methods for labeling oligonucleotides The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention. ... 11/23/06 - 20060263815 - Multiple snp for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided. ... 11/23/06 - 20060263814 - Markers of dna copy number alteration for improved prognostication in prostate cancer The invention describes DNA copy number alterations (CNAs), identifiable by technologies such as array-based comparative genomic hybridization (array CGH) or fluorescence in situ hybridization (FISH), that define distinct genetic subtypes of prostate cancer, and are useful for improved prognostication and treatment stratification for patients with prostate cancer. ... 11/23/06 - 20060263813 - Methods of monitoring functional status of transplants using gene panels Methods useful in monitoring the functional status of a transplant in a patient by detecting the expression levels of gene panels are described herein. Algorithms for analysis of the expression for monitoring the functional status of transplants are also described. ... 11/23/06 - 20060263812 - Ph dependent ion exchange material, solid substrate having the material immobilized on its surface, and method of isolating a nucleic acid using the material or the solid substrate B is —(CH2CHO)nOR2, wherein n is 1-20 and R2 is a C1-10 alkyl group or a protecting group, and the pH dependent ion exchange material having a degree of polymerization of 2-30,000. ... 11/23/06 - 20060263811 - Materials and kits for use in hot-start pcr, and methods of amplifying nucleic acids in a polymerase chain reaction Materials for sequestering reagents in hot-start PCR, kits containing such materials, and methods for the use of such materials in amplifying nucleic acids are described. ... 11/23/06 - 20060263810 - Species-specific, genus-specific and universal dna probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology labor DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida ... 11/23/06 - 20060263809 - Method for sensitive measure of low level apoptosis in cells Herein is described a method of detecting apoptotic cells and monitoring apoptosis in a caspase-independent manner. Cells are treated with a caspase inhibitor, and then a marker of apoptosis, such as a caspase-independent signaling protein, is detected for an extended period of time. When cells were suspended in the process ... 11/23/06 - 20060263808 - C-met mutations in lung cancer The invention provides methods and compositions useful for detecting mutations in c-met in lung cancer cells. ... 11/23/06 - 20060263807 - Methods for polymorphism identification and profiling The invention provides methods of using probe arrays For polymorphism identification and profiling. Such methods entail constructing a first array of probes that span and are complementary to one or more known DNA sequences. This array is hybridized with nucleic acid samples from different individuals to identify a collection of ... 11/23/06 - 20060263806 - Biomarkers for breast cancer Methods and compositions are provided for the detection of breast cancer based upon the identification of three biomarkers for non-normal breast cells. The biomarkers were identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer. Two biomarkers display increased expression in non-normal cells while ... 11/23/06 - 20060263805 - Diagnosing and treating potassium channel defects This documents relates to potassium channels, SUR2A polypeptides, mutant SUR2A polypeptides, and isolated nucleic acids encoding such polypeptides. In addition, this document provides methods for identifying an individual at risk for cardiac disease, methods for identifying an individual who will not respond to, or who is not responding to, conventional ... 11/23/06 - 20060263804 - Functional influenza virus-like particles (vlps) Recombinant influenza virus proteins, including influenza capsomers, subviral particles, virus-like particles (VLP), VLP complexes, and/or any portions of thereof, are provided as a vaccine for influenza viruses. The invention is based on the combination of two vaccine technologies: (1) intrinsically safe recombinant vaccine technology, and (2) highly immunogenic, self-assembled protein ... 11/23/06 - 20060263803 - Stem cell growth factor-like polypeptides The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. In particular, the invention relates to novel stem cell growth factor-like polypeptides, including novel proteins named SCGF3248Fk081_aa2, SCGF3248Fk081_aa1, SCGFFk081_aa3, and SCGF323401Fe131_aa1. Other ... 11/23/06 - 20060263802 - Antigenic peptides of rabies virus and uses thereof The present invention pertains to antigenic peptides of rabies virus and their use in the detection, prevention and/or treatment of conditions resulting from rabies virus. ... 11/23/06 - 20060263801 - Methods of high-throughput screening for internalizing antibodies This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand; ii) dissociating the reporter from the ligand and removing dissociated reporter from the surface of the cell; and iii) detecting the ... 11/23/06 - 20060263800 - Engineered protein kinases which can utilize modified nucleotide triphosphate substrates Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified ... 11/23/06 - 20060263799 - Macroporous support for chemical amplification reactions A method for carrying out an amplification of nucleic acids in pores of a two-dimensionally designed macroporous support material according to one embodiment includes the step of providing a predetermined part of a reaction mixture necessary for the amplification of a nucleic acid in pores of the support material. A ... 11/23/06 - 20060263798 - System and method for identification of microrna precursor sequences and corresponding mature microrna sequences from genomic sequences A method for determining microRNA precursors and their corresponding mature microRNAs from genomic sequences is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA precursor comprises the following steps. Patterns are generated by processing a collection of already known ... 11/23/06 - 20060263797 - Mild osteoarthritis biomarkers and uses thereof The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of ... 11/23/06 - 20060263796 - Dyslipoproteinemia associated with venous thrombosis The present invention provides methods of determining a human subject's risk for venous thrombosis based on the finding that venous thrombosis patients have significantly lower levels of large HDL particles, HDL-cholesterol and apolipoprotein Al and higher levels of small LDL particles, LDL-cholesterol and apolipoprotein B. Genotyping showed that venous thrombosis ... 11/23/06 - 20060263795 - Method and apparatus for facilitating the creation and analysis of microarrays A substrate holder is provided to move a slide containing a microarray of biomaterial through a biomaterial analysis process. The substrate holder includes a substrate loader that allows loading of slides into the substrate holder with minimal contact to the slide, thereby minimizing the amount of contamination on the slide. ... 11/23/06 - 20060263794 - Methods for detecting target nucleic acids using coupled ligation and amplification The present invention relates to the detection of nucleic acid sequences using coupled ligation and amplification. The coupling of ligation and amplification allows multiplex detection of nucleic acid sequences. The invention also relates to methods, reagents, and kits that employ addressable-support specific sequences in detecting nucleic acid sequences. ... 11/23/06 - 20060263793 - Novel linker compound, substrate coated with the compound, method of producing microarray using the compound and microarray produced by the method A compound represented by formula (4), a substrate coated with the compound, a method of producing a microarray using the compound, and a microarray produced by the method are provided. ... 11/23/06 - 20060263792 - Use of cr1-binding molecules in clearance and induction of immune responses The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement ... 11/23/06 - 20060263791 - Methods for diagnosis of alzheimer disease Methods for diagnosis or prognosis of late onset Alzheimer disease in an individual are provided which comprise detecting at least one polymorphism of a low-density lipoprotein receptor related protein 6 gene. ... 11/23/06 - 20060263790 - Methods for improving fidelity in a nucleic acid synthesis reaction The invention provides methods for nucleic acid sequence determination. Generally, the invention provides methods for improving fidelity of a nucleic acid synthesis reaction. ... 11/23/06 - 20060263789 - Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using Methods, systems and computer readable media for sequencing a biopolymer specimen and tracking a source from which the specimen was derived. Methods, systems and computer readable media for multiplex sequencing biopolymer samples. Methods, systems and computer readable media for efficiently sequencing biopolymeric specimens through a high-throughput sequencer. Methods, systems and ... 11/23/06 - 20060263788 - Human kinase interacting protein 2 (kip2)-related gene variant (kip2v1) associated with prostate cancer Nucleic acid and polypeptide sequences of one novel human KIP2-related gene variant (KIP2V1), and the processes for producing the same are provided. Use of the nucleic acid and polypeptide sequences of the gene variant in diagnosing diseases associated with the presence of KIP2V1, in particular prostate cancer, is also provided. ... 11/23/06 - 20060263787 - Immunoglobulin-like variable chain binding polypeptides and methods of use The invention provides an isolated diverse population of VH-like binding polypeptides. Each binding polypeptide within the population comprising an unascertained combination of an immunoglobulin VH region exon encoded polypeptide, a JH region exon encoded polypeptide and a D region exon encoded polypeptide, wherein the VH, D and JH region exon ... 11/23/06 - 20060263786 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of colon cancer Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon ... 11/23/06 - 20060263785 - Detection of aneuploidy A method for detecting aneuploidy of a chromosome comprises: a) obtaining a biological sample from a patient; b) preparing DNA from said sample for subsequent analysis; c) subjecting the DNA of said sample to a multiplex PCR reaction, using a multiplicity of markers, at least two per said chromosome of ... 11/23/06 - 20060263784 - Method for the diagnosis/prognosis of neuroblastoma The present invention relates to a method for neuroblastoma prognosis in a patient suffering from neuroblastoma, characterized in that it comprises the following steps: a. biological material is extracted from a biological sample taken from the patient, b. the biological material is brought into contact with at least one specific ... 11/23/06 - 20060263783 - Methods and systems for diagnosis of non-central nervous system (cns) diseases in cns samples The invention features methods, systems, and compositions for diagnosing noncentral nervous system (non-CNS) disorders by detecting changes in gene expression in the CNS, e.g., in cerebrospinal fluid, in brain or spinal cord tissue samples, or other bodily fluid samples. ... 11/23/06 - 20060263782 - Exciplexes The invention relates to the use of an organic solvent selected from 2,2,2-trifluoroethanol, ethylene glycol or ethylene glycol dimethyl ether for enhancing formation, potential formation, fluorescence and/or detection of an exciplex. The invention is applicable particularly to nucleic acid hybridisation assay using two polynucleotide probes that will hybridise to a ... 11/23/06 - 20060263781 - Regulation of cell surface proteins The invention relates to methods of screening for compounds that regulate the activity of cell surface proteins. The present invention relates to a method for regulating the insertion or retention of a protein, such as the cystic fibrosis transmembrane conductance regulator (CFTR), in a cell surface membrane. The invention also ... 11/23/06 - 20060263780 - Tagged polyfunctional reagents capble of reversibly binding target substances in a ph-dependent manner Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the ... 11/23/06 - 20060263779 - Method for the detection of cytosine methylation patterns with high sensitivity The present invention concerns a method for the detection of cytosine methylation in DNA samples, in which the following steps are conducted: a genomic DNA sample which comprises target DNA and background DNA is chemically treated such that all unmethylated cytosine bases are converted to uracil, while the 5-methylcytosine bases ... 11/23/06 - 20060263778 - Animals with reduced body fat and increased bone density Methods for identifying animals as having reduced body fat and increased bone density are provided herein. Also provided herein are methods for generating animals having reduced body fat and increased bone density. The methods provided herein are based on the effect of TLR4, MD-2, and CD14 activity on body fat ... 11/23/06 - 20060263777 - Sensitive sensing based on optical optical nonlinear wave mixing Techniques and systems for using nonlinear four wave mixing to optically measure microarrays with sample cells of biological or chemical materials. Examples of suitable microarrays include but are not limited to DNA microchips and capillary electrophoresis microarrays. ... 11/23/06 - 20060263776 - Serine protease This invention relates to a novel protein, termed INTP039, herein identified as a serine protease, in particular, as a member of the trypsin family of proteins and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of disease. ... 11/23/06 - 20060263775 - Elf3 gene compositions and methods ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5′ untranslated region, and a novel Alu, Alukwd. Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises ... 11/23/06 - 20060263774 - Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... 11/23/06 - 20060263773 - Measuring kit, measuring method and measuring apparatus of microorganism in liquid sample A flocculant 3 is kept sucked beforehand in a first syringe 2. Then, a liquid sample LS is sucked and agitated. Then, a first filter case 5 and a second filter case 6 are attached immediately to a leading end. Then, this mixture liquid 15 is filtered. Then, only the ... 11/23/06 - 20060263772 - Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids. ... 11/23/06 - 20060263771 - Nucleoside or nucleotides having novel unnatural bases and utilization of the same The object of the present invention is to provide a nucleoside or nucleotide having an unnatural base. The nucleoside or nucleotide of the present invention has a 5-substituted-2-oxo(1H)-pyridin-3-yl group as a base. Preferably, the 5-position of the above base is substituted with a substituent selected from the group consisting of ... 11/23/06 - 20060263770 - Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-4 (alpha and beta) and TREM-5 are disclosed. TREM-4 is a transmembrane glycoprotein expressed selectively in the endothelium of capillaries, in the ... 11/16/06 - 20060257924 - Process for the isolation of the extrachromosomal dna and method for the diagnosis based on the electrophoretic analysis of such dna A process is disclosed for the extraction and isolation of the extrachromosomal DNA from blood and cells with a view to detecting DNA alterations linked to a possible pathology in progress and making a diagnosis. The process for DNA extraction comprises the use of a buffer, a heat treatment, followed ... 11/16/06 - 20060257923 - High-throughput screening of expressed dna libraries in filamentous fungi The invention provides a method for the expression of exogenous DNA libraries in filamentous fungi. The fungi are capable of processing intron-containing eukaryotic genes, and also can carry out post-translational processing steps such as glyclosylation and protein folding. The invention provides for the use of fungi with altered morphology, which ... 11/16/06 - 20060257922 - Methods to detect cross-contamination between samples contacted with a multi-array substrate Methods and compositions for detecting cross-contamination between samples contacted with different arrays of a multi-array substrate are provided. The methods involve contacting sample to arrays of a multi-array substrate that contains cross-contamination probes in each of its arrays, and evaluating the resultant sample contacted arrays for cross-contamination between the samples. ... 11/16/06 - 20060257921 - Novel nucleic acid molecules and polypeptides encoding baboon tafi The present invention relates to the isolation and identification of novel baboon nucleic acid molecules and proteins and polypeptides encoded by such nucleic acid molecules, or degenerate variants thereof, which proteins and polypeptides comprise novel baboon thrombin-activatable fibrinolysis inhibitors or “TAFI” enzyme molecules. Because the novel baboon TAFI proteins and ... 11/16/06 - 20060257920 - Biomolecule retaining material and methods for attaching biomolecules to a surface The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or membranes. The material includes a substrate having a surface coating including a polyamine compound. In one embodiment, the method and material ... 11/16/06 - 20060257919 - Polymer-coated substrates for binding biological molecules A substrate, which that is capable of attaching biomolecules, and a method for preparing the substrate are provided. The substrate has a reactive surface that can covalently attach a polymer coating containing functional groups, which can reduce nonspecific binding of biomolecules to the surface for a biological array. Optionally, at ... 11/16/06 - 20060257918 - Polynucleotide encoding a novel human g-protein coupled receptor variant of the relaxin receptor hgprbmy5v1, and variants thereof The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the ... 11/16/06 - 20060257917 - Fluorescent dyes, energy transfer couples and methods Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays. ... 11/16/06 - 20060257916 - Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other ... 11/16/06 - 20060257915 - Methods of producing competitive aptamer fret reagents and assays Methods are described for the production and use of fluorescence resonance energy transfer (FRET)-based competitive displacement aptamer assay formats. The assay schemes involve FRET in which the analyte (target) is quencher (Q)-labeled and previously bound by a fluorophore (F)-labeled aptamer such that when unlabeled analyte is added to the system ... 11/16/06 - 20060257914 - Methods of producing interachain fluorophore-quencher fret-aptamers and assays The present invention describes methods for the production and use of single chain (single-stranded) fluorescence resonance energy transfer (“FRET”) DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte is bound and the FRET-aptamers are excited by ... 11/16/06 - 20060257913 - Genetic polymorphisms associated with myocardial infarction and uses thereof A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit ... 11/16/06 - 20060257912 - Methods and sequences to suppress primate huntington gene expression Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease. ... 11/16/06 - 20060257911 - G-protein coupled receptors The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host, cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC. ... 11/16/06 - 20060257910 - Process for aligning macromolecules by passage of a meniscus and applicaions The subject of the present invention is a process for aligning a macromolecule (macromolecules) on the surface S of a support, characterized in that the triple line S/A/B (meniscus) resulting from the contact between a solvent A and the surface S and a medium B is caused to move on ... 11/16/06 - 20060257909 - Methods for reducing the percentage of abnormal gametes The invention relates to methods of enriching a sperm sample for euploid sperm comprising obtaining a sperm sample from a mammalian male; contacting the sperm cells with a detectable DNA-interacting agent that imparts a sperm cell with a signal intensity proportional to the amount of DNA present in the sperm ... 11/16/06 - 20060257908 - Method for two- and three-dimensional microassembly of patterns and structures The present invention relates to a method for creating two- and three-dimensional arrays. Plates of sample materials are stacked to create primary stacks. Primary stacks are sliced to form combs. Combs are stacked to form secondary stacks. Secondary stacks are sliced to form tertiary plates or two-dimensional arrays. Tertiary plates ... 11/16/06 - 20060257907 - Packed bed for nucleic acid capture and amplification A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation ... 11/16/06 - 20060257906 - Compositions comprising a library of analytes for detection, quantification and analyses This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of ... 11/16/06 - 20060257905 - Methods of copying the methylation pattern of dna during isothermal amplification and microarrays A method for copying the methylation patterns of molecules of genomic DNA (MGD) during isothermal amplification of the MGD comprising obtaining MGD, copying the methylation patterns of the MGD using a DNA methylation-maintenance enzyme, while isothermally amplifying the MGD using a DNA polymerase with strand displacement activity, under conditions that ... 11/16/06 - 20060257904 - Agglomeration protein cascades, compositions and methods regarding the same Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular binding factor. The nucleic acid components, and methods of using them, to interact with agglomeration proteins are also disclosed herein. The nucleic acid ... 11/16/06 - 20060257903 - Compositions and methods for diagnosing and treating neuropsychiatric disorders The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering ... 11/16/06 - 20060257902 - Methods and compositions for depleting abundant rna transcripts The present invention concerns a system for isolating, depleting, and/or preventing the amplification of a targeted nucleic acid, such as mRNA or rRNA, from a sample comprising targeted and nontargeted nucleic acids. ... 11/16/06 - 20060257901 - Methods of diagnosing fetal trisomy 13 or a risk of fetal trisomy 13 during pregnancy Disclosed herein are methods for diagnosing fetal trisomy 13, or a risk of fetal trisomy 13, during pregnancy by detecting the levels of sFlt-1, VEGF, and PlGF in a subject. ... 11/16/06 - 20060257900 - Method for the discovery of high-affinity, high specificity oligonucleotide and derivatized oligonucleotide sequences for target recognition A method is disclosed to obtain oligonucleotide sequences with high affinity to target molecules. By design, the oligonucleotides have a defined primary and secondary structure. The affinity for binding to target species is classified or quantified by assay measurements using physical measurements rather than being based primarily on separations. Targets ... 11/16/06 - 20060257899 - Methods and apparatus for controlling dna amplification Apparatus for optimizing DNA amplification are provided. A DNA cycler in accordance with the invention preferably includes a detector capable of measuring a parameter of at least one stage of DNA amplification that changes as the reaction of said stage approaches completion. It is presently preferred that fluorescence be used ... 11/16/06 - 20060257898 - Method to detect lung cancer Certain embodiments of the present invention relate to methods for detecting lung cancer. ... 11/16/06 - 20060257897 - Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides ... 11/16/06 - 20060257896 - Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry. ... 11/16/06 - 20060257895 - Detection of chromosomal abnormalities associated with breast cancer Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative ... 11/16/06 - 20060257894 - Molecular typing of listeria monocytogenes, hybridization supports and kits for said molecular typing This invention provides 163 genes that are unique to the L. monocytogenes serovar 4b strain, CLIP80459, compared with L. monocytogenes EGDe strain. These genes are the basis for isolated nucleic acids, hybridization supports, and kits comprising a nucleotide sequence that is unique to a serovar 4b strain of L. monocytogenes. ... 11/16/06 - 20060257893 - Devices and methods for monitoring genomic dna of organisms The invention provides an apparatus that can be used in methods of preparing, amplifying, detecting, and/or optionally selecting for further analysis the genomic material from an organism for the rapid detection and/or classification of an organism in a sample (e.g., screening for, identifying, quantifying, and/or optionally further analyzing, e.g., sequencing, ... 11/16/06 - 20060257892 - Methods and compositions for treating a subject having an anthrax toxin mediated condition Methods and compositions for treating a subject for an anthrax toxin mediated disease condition are provided. Aspects of the subject methods include administering to a subject an effective amount of an agent that inhibits cellular internalization of an anthrax toxin, e.g., such as a LRP6 modulatory agent. Also provided are ... 11/16/06 - 20060257891 - Method for effecting the rapid release of a signature chemical from bacterial endospores, and for detection thereof A weak organic acid is used to effect the release of CaDPA from Bacillus or Clostridium endospores, rapidly and at room temperature, to enable detection and measurement of DPA and thereby the assessment of risk associated with exposure to Bacillus anthracis, Clostridium botulinum, and like spores. The method can be ... 11/16/06 - 20060257890 - Methods and compositions for cellular and metabolic engineering The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selection to “evolve” individual genes, whole plasmids or viruses, multigene clusters, or ... 11/16/06 - 20060257889 - Ribonuclease resistant rna preparation and utilization The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. ... 11/16/06 - 20060257888 - Genetic diagnosis using multiple sequence variant analysis The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention ... 11/16/06 - 20060257887 - Protein -protein interaction detection system using fluorescent protein microdomains The invention provides a protein labeling and interaction detection system based on engineered fragments of fluorescent and chromophoric proteins that require fused interacting polypeptides to drive the association of the fragments, and further are soluble and stable, and do not change the solubility of polypeptides to which they are fused. ... 11/16/06 - 20060257886 - Method for analyzing molecular fluorescence using evanescent illumination The present invention relates to a method for analyzing the behavior and states of molecules present in an interface region, and an apparatus for performing the method. ... 11/16/06 - 20060257885 - Homogeneous assay system A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay. ... 11/16/06 - 20060257884 - Methods for preparing and analyzing cells having chromosomal abnormalities The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells ... 11/16/06 - 20060257883 - Detection and measurement of hematological parameters characterizing cellular blood components Systems and methods for the diagnostic analysis of blood samples. The present invention uses sensor technology useful in the analysis of headspace sample from blood to provide an efficient and accurate means for identifying the presence of a volatile marker associated with hematological diseases or conditions. In a preferred embodiment, ... 11/16/06 - 20060257882 - Novel polynuceotides and polypeptides encoded thereby This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to human breast tumor-associated protein 47. The nucleic acid sequence is 1987 nucleotides long and contains an open reading frame from nucleotides 991 to 1447. The novel, encoded polypeptides comprise 152 amino acid residues. ... 11/16/06 - 20060257881 - Oligonucleotides for detecting male infertility The present invention provides a method, oligonucleotide probes and primers, and assay kits for diagnosing an individual as having hypospermatogenesis associated infertility that involves demonstrating in the individual the presence or absence of a variant form of a gene in exons 6, 7, 8 or 9 of the L-VDCC α1c ... 11/16/06 - 20060257880 - Gastric and prostate cancer associated antigens The invention relates to an antigen associated with cancers such as prostate and gastric cancers, known as T21. Nucleic acid sequences and polypeptide sequences encoding the antigen are provided, as are uses of such sequences. ... 11/16/06 - 20060257879 - Methods and kits for detecting an enzyme capable of modifying a nucleic acid The present invention provides a method of detecting an enzyme in a sample wherein the enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule, which thereby confers altered sensitivity of the nucleic acid molecule in a subsequent process. The invention also relates ... 11/16/06 - 20060257878 - Nucleic acid amplifier and method of nucleic acid amplification A nucleic acid amplifier including at least one flow channel in which a reaction solution made up of at least a nucleic acid template, a nucleic acid primer, a phosphate compound, and a metal ion, is caused to flow through the flow channel and to thereby perform nucleic acid amplification ... 11/16/06 - 20060257877 - Method for the validatable inactivation of pathogens in a biological fluid by irradiation A validatable method for determining a photochemically effective dose for inactivating pathogens in a fluid sample is described herein. In particular, the instant invention covers methods for determining a photochemically effective dose sufficient to inactivate pathogens in a biological sample while leaving biologically active substances of interest unaffected. A batch ... 11/16/06 - 20060257876 - Polymerase-based protocols for generating chimeric and combinatorial... The present invention relates to methods of generating chimeric oligonucleotides without the need for subcloning. The methods of the invention are polymerase-based, and may optionally be adapted for use with reagents available in commercially available mutagenesis kits such as Stratagene's QCM kits, to generate chimeric oligonucleotides in a quick, efficient ... 11/16/06 - 20060257875 - Affinity screening using one-bead-one-compound libraries The invention provides putative “drugable” protein targets and actively binding ligands identified in an efficient and reproducible process by determining the affinity of protein mixtures to libraries of ligand compounds of defined size and composition. The libraries are used to isolate and identify previously unknown corresponding protein-ligand binding pairs from ... 11/16/06 - 20060257874 - Method for determining the amount of template nucleic acid present in a sample A method for determining the amount of template nucleic acid present in a sample comprising the steps of: i) bringing into association with the sample all the components necessary for nucleic acid amplification, and all the components necessary for a bioluminescence assay for nucleic acid amplification and subsequently: ii) performing ... 11/16/06 - 20060257873 - Chemical switching of nucleic acid circuit elements Organic circuit elements and organic conductors are disclosed, together with electron acceptors and donors that may be chemically modified to alter the conductivity of the circuit or organic conductor. An organic circuit element includes a plurality of members, each of which includes an oligonucleotide duplex. The plurality of members includes ... 11/16/06 - 20060257872 - Cell lines and host nucleic acid sequences related to infectious disease Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or ... 11/16/06 - 20060257871 - One step real-time rt pcr kits for the universal detection of organisms in industrial products This invention is related to a novel sample preparation, probes, couple primer sets for one step real time reverse transcriptase polymerise chain reaction (RT-PCR), methods and kits for the universal detection of alive bacteria and/or fungus-yeast in pharmaceutical, cosmetic and non clinical samples. ... 11/16/06 - 20060257870 - Cdkl 1 as modifier of branching morphogenesis and methods of use Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided. ... 11/16/06 - 20060257869 - Short peptides from the '2nd loop' of 7 transmembrane receptor which selectively modulate signal transduction The present invention concerns compounds comprising, within short sequences from a specific regions of the 7TM receptor, that can modulate 7TM receptor-associated signal. The present invention further concerns methods for stimulation angiogenesis by administration of peptides derived from the EDG3 7TM-receptor. ... 11/16/06 - 20060257868 - Tissue specific genes and gene clusters Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods ... 11/16/06 - 20060257867 - Ghrelin binding nucleic acids The present invention is related to an antagonist of ghrelin, wherein the antagonist is a nucleic acid, and whereby preferably the nucleic acid is binding to ghrelin. ... 11/16/06 - 20060257866 - Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mrna decay The present invention relates to a method for screening and identifying compounds that modulate premature translation termination and/or nonsense-mediated messenger ribonucleic acid (“mRNA”) by interacting with a preselected target ribonucleic acid (“RNA”). In particular, the present invention relates to identifying compounds that bind to regions of the 28S ribosomal RNA ... 11/16/06 - 20060257865 - Method for identification and development of therapeutic agents The present invention relates generally to the field of identification and determination of bioactive amino acid sequences. In particular, the present invention provides method(s) for determining the influence of variation in host genes on selection of microorganisms with particular amino acid variants for the purpose of therapeutic drug or vaccine ... 11/16/06 - 20060257864 - Primers useful in polymerase chain reaction for the identification of subtypes c1, c2 and c3 of staphylococcal enterotoxin type c 5′-ATCAT ACCAA AAAGT ATTGC-3′. ... // - 5′-AAGAG ATTAT TTATT TCACGT-3′; - ... // - 5′-GTATC AGCAA CTAAA GTTAT-3′; - ... // - 5′-ACAGA GTTAT TAAAT GAAGG-3′; - ... 11/09/06 - 20060252092 - Pharmaceutical composition containing disrupted cell suspension of monilia albicans and euglobulin and method of treating animals infected with canine distemper virus or animals having neurological disorders by using the same Disclosed is a pharmaceutical composition which comprises a disrupted cell suspension of Monilia albicans and euglobulin as effective ingredients, wherein the disrupted cell suspension of the Monilia albicans is prepared by culturing the Monilia albicans in a liquid culture medium, centrifuging the resulting culture fluid, recovering the supernatant and disrupting ... 11/09/06 - 20060252091 - Materials and methods for detection of nucleic acids Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate ... 11/09/06 - 20060252090 - Nanomachine compositions and methods of use The invention provides a basic genetic operating system for an autonomous prototrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability. Also provided is a basic genetic operating system for an autonomous auxotrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability ... 11/09/06 - 20060252089 - Networked system for interactive communication and remote monitoring of individuals A system for remotely monitoring an individual. The system includes a server system for generating a script program from a set of queries. The script program is executable by a remote apparatus that displays information and/or a set of queries to the individual through a user interface. Responses to the ... 11/09/06 - 20060252088 - Detectable labels, methods of manufacture and use Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules. ... 11/09/06 - 20060252087 - Recovery of rare cells using a microchannel apparatus with patterned posts A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow path, extending between the upper ... 11/09/06 - 20060252086 - Process for producing vinylated nucleic acid This invention provides a process for producing a vinylated nucleic acid in an efficient and cost-effective manner through the implementation of vinylation of an amino-containing nucleic acid with a vinylating agent. This invention also provides a process for producing a vinylated nucleic acid in an efficient and cost-effective manner by ... 11/09/06 - 20060252085 - Methods of nucleic acid target capture Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a short time, are disclosed. Compositions that include ... 11/09/06 - 20060252084 - Method for the detection of risk factors associated with myocardial infarction A method for determining whether an individual is at an increased risk for myocardial infarction, comprising screening for the presence of Factor II and Factor XIII alleles associated with myocardial infarction. Also provided are kits and primers that specifically hybridize adjacent to the allele-specific regions of the Factor II and ... 11/09/06 - 20060252083 - Methods of synthesizing polynucleotides using thermostable enzymes Disclosed are methods of synthesizing a polynucleotide complementary to a target polynucleotide include steps of subjecting a non-thermophilic cell comprising a thermostable polymerase to a temperature effective to disrupt the cell to form a reaction mixture, wherein the reaction mixture comprises the target polynucleotide and one or more primers that ... 11/09/06 - 20060252082 - Predicting treatment response in cancer subjects The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of a gene, such as the RRM1 or ERCC1 gene. Compositions and kits useful for the methods are also provided. ... 11/09/06 - 20060252081 - Pna probes, mixtures, methods and kits pertaining to the determination of mycoplasma and related mollicutes This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes. ... 11/09/06 - 20060252080 - Feline hemoplasma isolate A newly identified hemoplasma agent, Candidatus Mycoplasma turicensis, is disclosed Also disclosed are detection methods, screening methods and methods of diagnosis for the hemoplasma agent. ... 11/09/06 - 20060252079 - Fluorescent detection system and dye set for use therewith A system is provided that can comprise: at least two excitation sources, each adapted to provide a different excitation wavelength than at least one other; at least one detector; and a plurality of spectrally resolvable dyes. A set of dyes is also provided and can comprise one or more energy ... 11/09/06 - 20060252078 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus The present invention describes novel SCCmec right extremity junction sequences for the detection of methicillin-resistant Staphyloccocus aureus (MRSA). It relates to the use of these DNA sequences for diagnostic purposes. ... 11/09/06 - 20060252077 - Stabilizing a nucleic acid for nucleic acid sequencing The invention provides methods for sequencing a nucleic acid comprising stabilizing a primer/target nucleic acid duplex on a substrate. Methods of the invention generally contemplate the use of a dual-anchored primer/target nucleic acid duplex, or a stabilizing molecule in a single molecule sequencing reaction. ... 11/09/06 - 20060252076 - Sir2 activity This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 ... 11/09/06 - 20060252075 - Method for monitoring anti-hiv treatment in hiv infected individuals The present invention relates to methods of monitoring and improving anti-HIV therapy in a subject. More specifically, the invention discloses that the presence or absence of an anti-Tat neutralizing activity in HIV infected subjects represents a reliable marker allowing the design of appropriate treatment protocols. The present invention also shows ... 11/09/06 - 20060252074 - Immobilization and reaction matrix for biosensors An immobilization and reaction matrix based on a polymeric hydrogel for biosensor chips is disclosed, in particular those based on semiconductor chips which are disposed on a completely processed wafer and have, applied thereto, sensor fields which are normally disposed in array format. Such biosensor chips are normally functionalized by ... 11/09/06 - 20060252073 - Compositions and methods for the treatment of cancer The present invention relates to cancer diagnostics and to compositions and methods for the identification of cancer therapeutics. In particular, the present invention provides compositions and methods for identifying therapeutic compounds that alter (e.g., eliminate or inhibit growth of) cancer stem cells without harming (e.g., that maintain (e.g., push into ... 11/09/06 - 20060252072 - Methods of identifying aberrant rna or rna targeted for cleavage by mirna or sirna The invention provides novel methods of identifying RNA that is targeted for cleavage by mRNA or siRNA or genes that give rise to aberrant RNA. The invention also provides the use in processes for identifying aberrant RNA or RNA targeted for cleavage by mRNA or siRNA of mutant eukaryotic cells ... 11/09/06 - 20060252071 - Method for the detection of chromosomal aneuploidies The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation ... 11/09/06 - 20060252070 - Multi-color light detection with imaging detectors Methods for biological sample multi-color light detection using color-image detectors with pixel filter arrays or multi-color pixels. ... 11/09/06 - 20060252069 - Pcr for mrsa sccmec typing A multiplex PCR assay for the detection, identification and classification of SCCmec types and sub-types of Staphylococcal aureus has been described. ... 11/09/06 - 20060252068 - Markers for prenatal diagnosis and monitoring Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a ... 11/09/06 - 20060252067 - Method and an apparatus for determining nucleotide sequence, and a computer program product to be executed by the apparatus A method for determining nucleotide sequence encompasses: injecting a solution containing a sample DNA into a chip cartridge provided with a detecting electrode, to which a probe DNA is immobilized; introducing an intercalator solution in the chip cartridge; obtaining a current-voltage characteristic curve by measuring a current in the solution ... 11/09/06 - 20060252066 - Compositions and methods for the therapy and diagnosis of kidney cancer Compositions and methods for the therapy and diagnosis of cancer, particularly kidney cancer, are disclosed. Illustrative compositions comprise one or more kidney tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. ... 11/09/06 - 20060252065 - Surface enhanced raman spectroscopy (sers) systems, substrates, fabrication thereof, and methods of use thereof Surface-enhanced Raman spectroscopic (SERS) systems including nanostructures and capable of detecting analytes, in particular biomolecules, of interest are provided. Methods of making the SERS systems and methods for detection of a biomolecule of interest, such as a virus or other infectious agent are also provided. ... 11/09/06 - 20060252064 - Polynucleotide primers and probes for rapid detection of group b streptococcus (gbs) The present invention relates to highly specific oligonucleotide primers and probes useful in a rapid and specific method for detecting the presence of Group B Streptococcal (GBS) or Streptococcus agalactiae infection in a biological sample. ... 11/09/06 - 20060252063 - Circular permutant gfp insertion folding reporters Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, ... 11/09/06 - 20060252062 - System and process for genetic and epigenetic treatment Transplantation of total or partial organs or tissues from one person to another creates severe immunologic problems and does not obtain a genetic rejuvenation, for example, of half the biological age of the donor's selected tissue. The invention permits, without a return to an embryonic stage, to develop an autologous ... 11/09/06 - 20060252061 - Diagnostic sequencing by a combination of specific cleavage and mass spectrometry The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the “diagnostic sequencing” of regions of sample nucleic acids for which a prototypic or reference sequence is already available (also referred to as “re-sequencing”), or which may be determined using ... 11/09/06 - 20060252060 - Direct multiplex characterization of genomic dna The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified. ... 11/09/06 - 20060252059 - Method and apparatus for analyzing genotype data Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing ... 11/09/06 - 20060252058 - Chip for detection of nucleic acid A testing chip for detecting a target nucleic acid from a liquid sample which at least comprises a support, a sample introduction part provided on the support, and a test region wherein an amplification reagent for amplifying the target nucleic acid is immobilized in the inside or on the surface ... 11/09/06 - 20060252057 - Lung cancer prognostics A method of providing a prognosis of lung cancer is conducted by analyzing the expression-of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them. ... 11/09/06 - 20060252056 - Markers for responsiveness to an erbb receptor tyrosine kinase inhibitor The invention relates to a set of isolated marker genes comprising at least one gene identified as having differential expression as between patients who are responders and non responders to an erbB receptor tyrosine kinase inhibitor; said gene set comprising one or more genes selected from at least the group ... 11/09/06 - 20060252055 - Diagnostics and therapeutics for cardiovascular disorders The kits and methods of the present invention relate to the diagnosis of cardiovascular disorders. In one aspect, the invention discloses a method and a kit for determining whether a subject has a fragile plaque disorder. In one aspect, the invention discloses a method and a kit for determining whether ... 11/09/06 - 20060252054 - Methods and compositions for detecting non-hematopoietic cells from a blood sample The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a ... 11/09/06 - 20060252053 - Bcl2l12 polypeptide activators and inhibitors The invention provides methods and materials related to Bcl2L12 polypeptides and the biological activities of Bcl2L12 polypeptides. For example, the invention provides methods and materials related to identifying activators and inhibitors of Bcl2L12 polypeptide activities such as the ability to block apoptosis and promote cell growth and transformation. The invention ... 11/09/06 - 20060252052 - Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having ... 11/09/06 - 20060252051 - Method for producing diverse libraries of encoded polymers Described are aminoacyl tRNA analogues which comprise a tRNA, and an amino acid which acts as an acceptor and donor substrate for ribosome-directed translation, thus, incorporating unusual monomers into non-standard polymers by the action of ribosomes. Also described are methods for producing such tRNA analogues; non-standard polymers; libraries of encoded ... 11/09/06 - 20060252050 - Genetic marker for weight regulation The present invention is directed to methods capable of predicting likely response to weight loss and weight management based on genetic polymorphisms in the perilipin (PLIN) locus. The invention also provides kits to determine whether an individual is resistant to weight gain or weight loss based on analysis of genetic ... 11/09/06 - 20060252049 - Growth-promoting and immunizing subcutaneous implant The present invention relates generally to an implant for use in animals. More particularly, the present invention relates to an implant including a pharmaceutical agent and a biological agent for use in animals to promote growth, regulate metabolism and prevent illness or disease. A method for promoting growth and immunity ... 11/09/06 - 20060252048 - Method for testing ghrelin release The present invention provides a model to study the (regulation of) expression, synthesis and/or secretion of ghrelin in humans. Ghrelin is a hormone that signals appetite and stimulates food intake. The model of this invention comprises the culture of a cell line derived from a human gastric adenocarcinoma that is ... 11/09/06 - 20060252047 - Device and method for analysis of samples using a combined sample treatment and sample carrier device The invention relates to devices and methods for chemical analysis, specifically to devices for extracting molecules, e.g. biomolecules such as peptides, and/or proteins, from a mixture of molecules in a solution and performing sample treatment on the extracted molecules before presenting them to an analysis instrument. The method for analysis ... 11/09/06 - 20060252046 - Plasma polymerisation methods for the deposition of chemical gradients and surfaces displaying gradient of immobilised biomolecules The invention relates to a method to prepare at least part of at least one surface of a substrate comprising depositing on the surface at least one plasma monomer from a monomer source wherein during deposition of said monomer said monomer and/or said surface are moved relative to one another ... 11/09/06 - 20060252045 - Methods and materials for identifying agents which modulate bone remodeling and agents identified thereby The invention discloses compositions, compounds, apparatuses and methods of using them to study bone mineralization and identify agents that regulate bone mineralization. Methods of using bone mineralization gene profiles and signatures for compound screening and research are also disclosed. Reagents for modulating bone mineralization are provided for both therapeutic and ... 11/09/06 - 20060252044 - Biochip and biochip kit, and method of producing the same and method of using the same There are provided a biochip and a biochip kit, in which a target contained in an analyte is reacted with a probe with high efficiency in a short time, B/F separation efficiency is high, and high-sensitive quantitative determination and detection can be realized, and a production process thereof, and a ... 11/09/06 - 20060252043 - Method for in vitro detection aberrant dysplasia, and the artificial nucleotides being used The present invention provides a method for in vitro detection of malignant potential of dysplasia by aberrant methylation of p16 CpG islands, comprising extraction of genomic DNA from a tissue or body fluid sample, analysis of methylation status of p16 CpG islands in the extracted DNA, and evaluation of malignant ... 11/09/06 - 20060252042 - Methods of treatment of feeding disorders or disorders of glucose uptake and for modifying metabolism and identifying therapeutic reagents therefor The present invention provides several assay formats for determining the effect of compounds on one or more metabolism-associated phenotypes in a cell, tissue or animal. The assay formats are based upon the finding that the proto-oncogene Cbl is involved in modulating basal glucose uptake, metabolic rate, adipogenesis, muscle thermogenesis, mitochondrial ... 11/09/06 - 20060252041 - Pcr-based diagnostic method of detecting a mutation in the b-raf gene This disclosure relates to a PCR based method for detecting a mutation in the B-RAF gene which involves utilizing a primer that is complementary to the mutated base(s) and detecting the mutation by determining whether amplification of the DNA occurs. ... 11/09/06 - 20060252040 - Strand specific detection and quantification An aspect of the present invention provides for specific compositions and methods of use make possible accurate, simple and efficient detection and quantification of desired nucleic acid strands. Teachings of the present invention also provide for novel and efficient primer design for annealing to specific target nucleic acid strands, as ... 11/09/06 - 20060252039 - Novel allelic variants in the factor vii gene The presence of at least one of said allelic variants affects the stability and/or functionality of the nucleic acid molecule and/or of the product coded by said nucleic acid molecule. The procedure for analyzing a nucleic acid molecule comprises obtaining said molecule from a biological sample and determining at least ... 11/09/06 - 20060252038 - Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry This invention provides methods for detecting single nucleotide polymorphisms and multiplex genotyping using dideoxynucleotides and mass spectrometry. ... 11/09/06 - 20060252037 - Kinase suppressor of ras inactivation for therapy of ras mediated tumorigenesis The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid ... 11/09/06 - 20060252036 - Alteration of rab38 function to modulate mammalian pigmentation The present invention relates to compositions and methods involving melanocytes. In particular, the present invention provides compositions and methods involving RAB38 and mutant RAB38, suitable for use in modulation of pigmentation and for use in determining the means to diagnose and/or treat conditions associated with disorders in pigmentation. ... 11/09/06 - 20060252035 - Sphks as modifiers of the p53 pathway and methods of use Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided. ... 11/09/06 - 20060252034 - Novel protein containing ring finger domaine r1p4 R1P4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing R1P4 polypeptides and polynucleotides in diagnostic assays. ... 11/02/06 - 20060246504 - Detection and treatment of polycystic kidney disease Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. Methods for diagnosing a mutant PKD1 gene sequence in a subject also are provided, as are methods ... 11/02/06 - 20060246503 - Method for rapid amplification of dna The present disclosure relates to methods of DNA amplification with a first primer that has a random sequence of nucleotides at its 3′ end and a generic sequence 5′ of the random nucleotides, as well as a second primer with the generic sequence of the first primer. The disclosure further ... 11/02/06 - 20060246502 - Rabconnectin-3-binding protein A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an ... 11/02/06 - 20060246501 - Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample An extraction and analysis device includes a microfluidic based collection system that extracts one or more different analytes from a fluid-based sample and an optical analysis system directly coupled to the collection system to perform optical analysis on the one or more collected analytes. The microfluidic based collection system includes ... 11/02/06 - 20060246500 - Polynucleotide detection method employing self-reporting dual inversion probes Method of detecting a target polynucleotide based on the use of dual inversion hybridization probes having stem-and-loop structures, wherein the stem portion of the structure comprises a pair of interactive arms that are substantially prevented from interac |