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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip > Involving Nucleic Acid Involving Nucleic AcidInvolving Nucleic Acid patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.06/07/07 - 20070128656 - Direct fluorescent label incorporation via 1st strand cdna synthesis The present invention provides for highly efficient fluorescent label incorporation during 1st strand complimentary DNA (cDNA) synthesis. This is achieved by the use of labeled random primers (including, but not limited to, random hexamers, septamers, octamers, nonamers and decamers) rather than labeled nucleotides. This invention thus bypasses the well known ... 06/07/07 - 20070128655 - Breast, gastric and prostate cancer associated antigens and uses therefor Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in breast, gastric and prostate cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with cancer. The invention ... 06/07/07 - 20070128654 - Universal-tagged oligonucleotide primers and methods of use The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome. ... 06/07/07 - 20070128653 - Human hac3 The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes ... 06/07/07 - 20070128652 - Fluid processing device comprising radial channels The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) ... 06/07/07 - 20070128651 - Promoter sequences and the use thereof The promoter region and various fragments thereof for the yellow fever mosquito (Aedes aegypti) ribonucleotide reductase small subunit (R2) are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences. ... 06/07/07 - 20070128650 - Solid phase rflp-based snp detection The invention is directed to a method for detection of single nucleotide polymorphisms utilizing a solid phase RFLP-based method of detection. The invention further relates to a method of detecting a single nucleotide polymorphism (SNP) comprising providing a sample test DNA molecule containing an SNP site of interest; detectably labeling ... 06/07/07 - 20070128649 - Synthesis of error-minimized nucleic acid molecules A method is provided for synthesis of error-minimized nucleic acid molecules. Oligonucleotides intended to have fragments of a desired, full-length nucleotide sequence, and optionally containing other desired nucleotides, such as nucleotides for binding the oligonucleotides to a substrate, are obtained. Oligonucleotides for both strands of the desired, full-length sequence may ... 06/07/07 - 20070128648 - Methods for the identification of ikkalpha function and other genes useful for treatment of inflammatory diseases The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-κB pathway; determining the level of expression of ... 06/07/07 - 20070128647 - Methods for high throughput genotyping Methods for genotyping polymorphisms using allele specific probes are disclosed. A training set is used to generate a model for each polymorphism to be interrogated. The training set is used to obtain an estimate of the asymmetry between an intensity measurement for a first allele and an intensity measurement for ... 06/07/07 - 20070128646 - Hybridization of pna probes in alcohol solutions This invention features methods, kits and compositions for hybridization of PNA probes in diagnostic applications. This invention is further directed toward the use of said methods, kits and compositions for both fixation of cells and hybridization to nucleic acid targets within fixed cells. ... 06/07/07 - 20070128645 - Use of kiaa0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a ... 06/07/07 - 20070128644 - Fluid control method and fluid control apparatus The object of the present invention is to enable a probe to uniformly encounter biopolymers in a sample solution, regardless of a position in a reaction chamber. In the present invention, a fluid displacement between a reaction chamber and ports communicating therewith in a biochemical reaction part is controlled by ... 06/07/07 - 20070128643 - Method for assaying nucleic acid fragment and kit thereof The present invention is related to a novel method for assaying high quantity of nucleic acid fragments, by using the single-stranded anchor nucleic acid probe with biotin and this single-stranded anchor nucleic acid hereto form double-stranded nucleic acid with the target nucleic acid fragment. To detect the target fragment does ... 06/07/07 - 20070128642 - Method of isolation and self-assembly of small protein particles from blood and other biological materials Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation ... 06/07/07 - 20070128641 - Sirna targeting hypoxia-inducible factor 1 Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. ... 06/07/07 - 20070128640 - Sirna targeting ras-related nuclear protein Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. ... 06/07/07 - 20070128639 - Molecular profiling of cancer The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides cancer markers useful in the diagnosis and characterization of prostate and breast cancers. ... 06/07/07 - 20070128638 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes. ... 06/07/07 - 20070128637 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes. ... 06/07/07 - 20070128636 - Predictors of patient response to treatment with egfr inhibitors The invention concerns genes and gene sets and methods useful in the prediction of the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor. ... 06/07/07 - 20070128635 - Selected amplification of polynucleotides The invention provides methods and compositions for selectively amplifying one or more target polynucleotides in a sample. In one aspect, a plurality of selection oligonucleotides are provided that are capable of simultaneously annealing to separate regions of a target polynucleotide to form a complex that is enzymatically converted into a ... 06/07/07 - 20070128634 - Separation and purification of nucleic acid from paraffin-containing samples Disclosed are rapid and reproducible methods for separating and purifying nucleic acids from paraffin-containing tissue samples. The disclosed methods involve a melting step, where paraffin-containing tissue samples are heated in the presence of a detergent, causing the paraffin to melt and tissue sample cells to lyse. From the resulting two-phase ... 06/07/07 - 20070128633 - Cell-free protein expression systems and methods of use thereof Provided herein are in vitro (cell-free) protein translation (IVT) systems for the expression of kinases. In particular, provided herein is an IVT system for the expression of a panel of protein tyrosine kinases (PTK), (e.g., receptor protein tyrosine kinases (RTK) and/or cytoplasmic tyrosine kinases (CTK)), and/or fragments thereof (e.g., kinase ... 06/07/07 - 20070128632 - Methods for amplification of nucleic acids using spanning primers The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences. ... 06/07/07 - 20070128631 - Gene finding using ordered sets A method and system for finding in a DNA sequence, a gene represented by an ordered set of marker strings. Sub-strings in the DNA sequence matching each marker string are identified. In a set ordered via occurrence of the marker strings in the ordered set of marker strings, the score ... 06/07/07 - 20070128630 - Hpv cd8+ t-cell epitopes The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention ... 06/07/07 - 20070128629 - Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing There is provided a method for directly typing or sequencing HLA-A, -B, or -C alleles from a tissue sample wherein exons 2 and 3 of the HLA-A, -B, or -C alleles from the sample are amplified together in a locus specific manner and then separated out and individually amplified in ... 06/07/07 - 20070128628 - Universal method for selective amplification of mrnas The invention relates generally to methods for the amplification of ribonucleic acids, including for example messenger ribonucleic acids (mRNAs). In an embodiment, the invention also relates to kits for amplifying ribonucleic acids, including for example mRNAs. In another embodiment, the invention relates to kits comprising the components for performing the ... 06/07/07 - 20070128627 - Novel cofactor that modulates steroid receptor activities The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ... 06/07/07 - 20070128626 - Assessing response to anti-cd20 therapy by genotyping c1q components The present invention encompasses methods for predicting metastasis in cancer by assessing the structure of the complement protein C1qA. The methods may encompass examining either protein or nucleic acids, and may further include making treatment decisions based on the predictive methods. ... 06/07/07 - 20070128625 - Drug-resistant mutants of hepatitis c virus The present invention provides nucleotides, peptides, HCV mutants, and cell lines containing mutations associated with drug resistance. In addition, the present invention provides methods for screening for therapeutic compounds capable of inhibiting HCV as well as methods for inhibiting HCV, e.g., by targeting specific binding sites associated with HCV drug ... 06/07/07 - 20070128624 - Method of preparing libraries of template polynucleotides The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5′ ends and at their ... 06/07/07 - 20070128623 - Biomolecule interaction using atomic force microscope The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the ... 06/07/07 - 20070128622 - Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera Our invention relates to a new way of preparing coding DNA constructs, by making a chimera of various coding region isoforms. For example, our method has been successfully used to make a new hGH-NV cDNA chimera having SEQ ID NO: 3, by combining the cDNA isoforms of human placenta and ... 06/07/07 - 20070128621 - Analyzing messenger rna and micro rna in the same reaction mixture The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, ... 06/07/07 - 20070128620 - Hot start reverse transcription by primer design The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target polynucleotide with a hot start primer comprising a blunt-ended self-complementary stem, and a loop, and extension products form at high temperatures but reduce extension product ... 06/07/07 - 20070128619 - Human fgf-21 gene and gene expression products This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-2 1. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, ... 06/07/07 - 20070128618 - Systems and methods for characterization of molecules The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as ... 06/07/07 - 20070128617 - Hybridization-mediated analysis of polymorphisms Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is ... 06/07/07 - 20070128616 - Aggrecanase molecules Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed. ... 06/07/07 - 20070128615 - Methods for determining nucleotide sequence information Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences ... 06/07/07 - 20070128614 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 06/07/07 - 20070128613 - Pcr based capsular typing method The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci. ... 06/07/07 - 20070128612 - Dna family tree kit A DNA family tree kit includes a storage case configured to receive a plurality of DNA storage boxes, a variety of mechanisms for collecting samples of DNA family members and a genealogical organization system that includes a family tree. A method of collecting, storing and categorizing DNA includes collecting at ... 06/07/07 - 20070128611 - Negative control probes In an embodiment, a method is included for generating a negative control probe sequence for an array including selecting biological probe sequences from the array randomly, generating a plurality of candidate probe sequences by randomly permuting the selected biological probe sequence, and screening the candidate probe sequences for sequence similarity ... 06/07/07 - 20070128610 - Sample preparation method and apparatus for nucleic acid sequencing The invention provides methods and apparatus for preparation and sequencing of nucleic acids. ... 06/07/07 - 20070128609 - Ddr2 protein with activated kinase activity and preparation method thereof The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase ... 06/07/07 - 20070128608 - Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor [Problems] To provide a novel mixture for assaying a target nucleic acid, characterized by enabling a nucleic acid assay while: 1) requiring no step of diluting the target nucleic acid; 2) requiring no procedure of changing a probe concentration depending on a concentration of the target nucleic acid. [Means for ... 06/07/07 - 20070128607 - Method for distinguishing aml subtypes with different gene dosages Disclosed is a method for distinguishing AML subtypes with different gene dosages selected from AML-TRI8, AML-TRI11, AML-TRI13, AML-MO7, and/or AML-DEL5q in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers. ... 06/07/07 - 20070128606 - Prkcs as modifiers of the beta catenin pathway and methods of use Human PRKC genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PRKC are provided. ... 06/07/07 - 20070128605 - Triacylglycerol-deficient fission yeast and its uses A fission yeast having non-functional dga1 and plh1 genes, which is incapable of synthesizing triacylglycerols, is disclosed. The fission yeast is susceptible to lipotoxicity including lipoapoptosis, and is useful for screening of compounds that inhibit or prevent lipotoxicity or lipoapoptosis. The fission yeast strain may be transformed to express a ... 06/07/07 - 20070128604 - Variants of human taste receptor genes Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele ... 06/07/07 - 20070128603 - Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7) The invention provides a human 5-HT7 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention ... 06/07/07 - 20070128602 - Polynucleotide associated with a colon cancer comprising single nucleotide poylmorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof. ... 06/07/07 - 20070128601 - Identification and characterization of racemases, definition of protein signatures, and a test for detecting d-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs ... 06/07/07 - 20070128600 - Alpha macroglobulin family member This invention relates to a protein, termed INSP097, herein identified as a member of the alpha macroglobulin family, in particular as an alpha-2-macroglobulin-like proteinase inhibitor, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. ... 06/07/07 - 20070128599 - Method for improved diagnosis of dysplasias The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without ... 06/07/07 - 20070128598 - Methods for generating rna copies The present invention is directed to a novel method of efficiently synthesizing, in a non-specific manner, multiple copies of a target RNA. The present invention also relates to kits relating to the same and the use of these copies for determining gene expression pattern. In particular, the present invention relates ... 06/07/07 - 20070128597 - Single nucleotide polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy Single Nucleotide Polymorphisms sensitively predicting Advserse Drug Reactions (ADR) and Drug Efficacy Abs tract. The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the ... 06/07/07 - 20070128596 - Reagents and methods for identifying and modulating expression of tumor senescence genes This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression ... 06/07/07 - 20070128595 - Novel polynucleotide and polypeptide sequences and uses thereof The present invention provides a purified nucleic acid encoding a putative transmembrane receptor polypeptide comprising at its N-terminus leucine rich repeats and at least an immunoglobulin domain. S30-21616/DEGA polypeptide of the present invention, analogs of said polypeptide, vectors and host cells that embody the polynucleotides, bio-immunopharmaceutical compositions and diagnostic reagents ... 06/07/07 - 20070128594 - Protein c polymorphisms The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined ... 06/07/07 - 20070128593 - Sga-1m, a cancer associated antigen, and uses thereof The present invention relates to a gene and gene product, SGA-1M that is differentially expressed in cancer tissues and cell lines. Suppression Subtractive Hybridization and microarray screening were used to screen for differential expression of SGA-1M in cancer tissues and cell lines. Expression analysis has demonstrated overexpression of SGA-1M in ... 06/07/07 - 20070128592 - Method and nucleic acids for the analysis of a lung cell proliferative disorder The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders, ... 06/07/07 - 20070128591 - Methods for diagnosing and treating diseases and conditions of the digestive system and cancer The invention provides methods of diagnosing diseases and conditions of the digestive system and cancer, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in ... 06/07/07 - 20070128590 - Methods for determining therapeutic resonant frequencies Methods are provided for readily and efficiently determining resonant frequencies that can be used therapeutically or beneficially, for debilitation of specific types of genomic materials, including DNA and/or RNA, genes, and gene sections. The methods can be used in a variety of circumstances related to various human and animal diseases ... 05/31/07 - 20070122839 - Methods and compositions for nucleic acid analysis The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides. ... 05/31/07 - 20070122838 - Methods and computer software products for identifying transcribed regions of a genome Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning ... 05/31/07 - 20070122837 - Mothod for the synthesis of dna sequences A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into smaller overlapping DNA segments. A maskless microarray synthesizer is used to make a DNA microarray on ... 05/31/07 - 20070122836 - Control of tgfbeta signaling by km23 superfamily members Methods of identifying therapeutic agents that inhibit, potentiate or mimic the ability of a km23 polypeptide mutant form, or a nucleic acid encoding the mutant form to modulate the signal transduction activity of a growth factor or cytokine are provided. The methods involve treating a cell with a candidate compound ... 05/31/07 - 20070122835 - Methods for detection of genetic disorders The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present ... 05/31/07 - 20070122834 - Biochip substrate holding method and biochip-reader The present invention is characterized by the following points: In measurement of a biochip whose substrate is held on a base and samples are spotted onto the sites in an array on the substrate, a biochip substrate holding method, which does not generate deviation of site positions between the arrangement ... 05/31/07 - 20070122833 - Enzymatic deposition and alteration of metals Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is ... 05/31/07 - 20070122832 - Process for preparing l-amino acids The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which ... 05/31/07 - 20070122831 - Detection and source identification of microbial contaminants in water samples The present invention relates generally to methods of microbial source tracking in environmental water samples. More specifically the present invention relates to methods of microbial source tracking using detection of Bifidobacterium species as markers of source contamination in environmental water samples. The present invention utilizes differences in DNA sequence between ... 05/31/07 - 20070122830 - Prohibitin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance Disclosed are methods for treating neoplastic cells, including reversing or preventing chemotherapeutic drug resistance, by increasing the sensitivity of the neoplastic cells to a chemotherapeutic drug. In addition, methods are further disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of prohibitin in ... 05/31/07 - 20070122829 - Device and method for measuring analytes The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at ... 05/31/07 - 20070122828 - Short cycle methods for sequencing polynucleotides The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion. ... 05/31/07 - 20070122827 - Target nucleic acid signal detection Provided herein are methods, compositions and kits for detecting a target nucleic acid. A target nucleic acid can be produced, for example, by a cleavage reaction in an assay for detection of biological samples. In one aspect, a described method comprises the following steps: hybridizing the target nucleic acid having ... 05/31/07 - 20070122826 - Minimal bacterial genome The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set ... 05/31/07 - 20070122825 - Method to predict the response to lithium treatment The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment. ... 05/31/07 - 20070122824 - Method and kit for assessing a patient's genetic information, lifestyle and environment conditions, and providing a tailored therapeutic regime A method of determining a personalised therapeutic regime, comprising: receiving genetic information relating to a patient; determining genetic criteria relevant to a personalised therapeutic regime for the patient using the genetic information; receiving personal information relating to the patient; determining personal criteria relevant to the personalised therapeutic regime using the ... 05/31/07 - 20070122823 - Amniotic fluid cell-free fetal dna fragment size pattern for prenatal diagnosis The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include analysis of the fragment size distribution of cell-free fetal DNA isolated from amniotic fluid. The inventive methods allow for rapid screening of fetal characteristics such as chromosomal abnormalities and for prenatal diagnosis ... 05/31/07 - 20070122822 - Compositions and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group. ... 05/31/07 - 20070122821 - Antisense composition and method for treating muscle atrophy A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has ... 05/31/07 - 20070122820 - Balanced translocation in comparative hybridization The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations. ... 05/31/07 - 20070122819 - Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same The object of the present invention is to provide a sample assay structure in a microfluidic chip for quantitative analysis which comprises a sample inlet port for inputting a testing sample; an analyte detection region, coupled to the sample inlet port, consisting of at least one microfluidic channel, in which ... 05/31/07 - 20070122818 - Gene methylation assay controls Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them. ... 05/31/07 - 20070122817 - Methods for assembly of high fidelity synthetic polynucleotides Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or ... 05/31/07 - 20070122816 - Microarray comprising qc probes and method for fabricating the same A quality control (QC) probe for inspecting a quality of a microarray, a method for fabricating a microarray in which the QC probe and a target probe are immobilized on a support, and a method for inspecting the quality of a microarray using the QC probe are provided. More particularly, ... 05/31/07 - 20070122815 - Solid support for nucleic acid detection The present invention relates to solid supports for control nucleic acids. The present invention also relates to methods for the manufacture thereof, and methods of use thereof. ... 05/31/07 - 20070122814 - Methods for distinguishing prognostically definable aml Disclosed is a method for distinguishing prognostically definable AML subtypes with normal karyotype into different prognosis subsets in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers. ... 05/31/07 - 20070122813 - Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the ... 05/31/07 - 20070122812 - Method of screening for protein secretion recombinant host cells The invention describes a method of screening for protein secreting recombinant host cells comprising screening for promoter activity of a stress inducible promoter. The method can be used for rapid identification of actively secreting transformants and can be used to screen recombinant libraries for transformants secreting proteins. ... 05/31/07 - 20070122811 - Compositions and processes for genotyping single nucleotide polymorphisms The invention relates to processes, compositions and kits for analysis of nucleic acid variations, especially single nucleotide polymorphisms (SNPs). An inventive process includes a procedure to enzymatically remove inorganic pyrophosphate from a sample prior to and/or during a single base extension reaction. Processes and compositions described herein are especially useful ... 05/31/07 - 20070122810 - Brain tumor marker and method of diagnosing brain tumor The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein ... 05/31/07 - 20070122809 - Nucleic acid isolation The invention provides materials and methods for purifying nucleic acids from a biological sample held in a container (30) such as a centrifuge tube. A filtration unit (1) having a filter (7, 9) and a filtrate chamber (5) is placed within the container (30). Preferably the exterior of the filtration ... 05/31/07 - 20070122808 - Measurement of a polynuleotide amplification reaction A quantitative measurement of the progress of a polynucleotide amplification reaction can be made by: (i) carrying out a reaction for the amplification of a target polynucleotide; (ii) either during or after the amplification reaction contacting the amplified product with a molecule that binds to or interacts with a polynucleotide, ... 05/31/07 - 20070122807 - Posh polypeptides, complexes and related methods The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as neurological disorders. ... 05/31/07 - 20070122806 - Predicting graft rejection The present invention features prognostic methods useful in assessing patients who have received a transplant and reagents, optionally packaged as kits or organized as arrays, that can be used to carry out those methods. The inventions are based, in part, on our analysis of gene expression in renal allografts and ... 05/31/07 - 20070122805 - Haplotype analysis The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these ... 05/31/07 - 20070122804 - Combined exponential and linear amplification Methods and compositions are provided for sensitive detection and quantitation of nucleic acids. Methods and compositions are further provided for genotyping. Probes of the invention allow target initiated amplification for single stranded, double stranded polynucleotides and pyrophosphate (PPi). DNA enzyme mediated detection method is also provided for detecting single stranded ... 05/31/07 - 20070122803 - Methods for the detection of polymorphisms in the human oatpf gene The invention provides a method for the detection of a polymorphism in OATPF in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of ... 05/31/07 - 20070122802 - Methods of diagnosing and treating diabetes and insulin resistance The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels ... 05/24/07 - 20070117146 - Allelic variants of gpr50 The present invention provides isolated polynucleotides encoding a receptor gene called GPR50 having at least one polymorphic sites. It furthermore provides a method for analyzing polymorphic sites in the receptor gene. Certain of these polynucleotides having a polymorphic site (allelic variants) are found to be more prevelant in a population ... 05/24/07 - 20070117145 - Interferon-alpha induced genes The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-α administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression ... 05/24/07 - 20070117144 - Oligonucleotides useful for detecting and analyzing nucleic acids of interest The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a ... 05/24/07 - 20070117143 - Atm related kinase atx, nucleic acids encoding same and methods of use The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as ... 05/24/07 - 20070117142 - Regulation of novel human asparagine-hydroxylases Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders. ... 05/24/07 - 20070117141 - Identification and cloning of a full-length human clnk-related gene, mist (mast cell immunoreceptor signal transducer) The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or ... 05/24/07 - 20070117140 - Method for selecting antimicrobial agent and utilization thereof The present invention provides for a method for selecting an antimicrobial agent, which comprises a microbe analyzing step in which microbes in the microbial biota of a sample are analyzed based on base sequence of DNA and an antimicrobial agent selecting step comprising performing search in a data base storing ... 05/24/07 - 20070117139 - Method of manufacturing probe carrier A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of ... 05/24/07 - 20070117138 - Splice variant cannabinoid receptor (cb1b) The invention is based on the identification of a novel splice variant of human cannabinoid 1 (CB1) receptor, termed CB1b, and its use in the identification of therapeutic agents and in the diagnosis, prevention and treatment of CB associated disorders such as obesity, psychiatric, pain and neurological disorders. ... 05/24/07 - 20070117137 - Method for the determination of a nucleic acid using a control The present invention is directed to a method for the determination of a target nucleic acid using a special control nucleic acid, a method for the amplification of a partial sequence of said target nucleic acid using primers, a special control and a kit containing said control. The sequence of ... 05/24/07 - 20070117136 - Detection of microsatellite instability and its use in diagnosis of tumors Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to ... 05/24/07 - 20070117135 - Method of inoculation for evaluating candidate therapies for prevention of acquisition of infectious diseases A method of inoculating the vestibular region of the nares with virus, bacteria, fungus, or mold to ascertain whether acquisition and/or prevention of transmission of infection may occur. ... 05/24/07 - 20070117134 - Method for detection and quantification of t-cell receptor vbeta repertoire The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the ... 05/24/07 - 20070117133 - Sparc and methods of use thereof The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of ... 05/24/07 - 20070117132 - System and method for analyzing dependence between gene expressions An amplification-like, unidirectional dependence between expression levels in gene pairs is identified through statistical analysis including a determination of whether there is a specified level of independence (or non-correlation) between X and Z, where X is a random variable representing the expression level of a first gene, Y is a ... 05/24/07 - 20070117131 - Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process Novel processes for the replication of influenza viruses in cell culture, and vaccines and diagnostic compositions which contain the influenza viruses obtainable by the process or constituents thereof, are described. ... 05/24/07 - 20070117130 - Novel activin receptor and uses thereof The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also ... 05/24/07 - 20070117129 - Antigen arrays for treatment of bone disease The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a ... 05/24/07 - 20070117128 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of ... 05/24/07 - 20070117127 - Cross-species nucleic acid probes The present invention features a collection of at least four nucleic acid probes. The probes each comprises a segment, the entirety of which hybridizes under low stringency conditions to at least a first gene of a first species and a second gene of a second species, wherein the hybridizing probes ... 05/24/07 - 20070117126 - Shotgun scanning A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics. ... 05/24/07 - 20070117125 - Method of detecting specific fragments of dna or rna with the aid of a real-time polymerase chain reaction Methods of amplifying specific fragments of DNA or RNA with the aid of a polymerase chain reaction in real time are disclosed. The methods include providing a first oligonucleotide primer that comprises a donor fluorescent dye and a second oligonucleotide primer that comprises an acceptor fluorescent dye; allowing the primers ... 05/24/07 - 20070117124 - Achaete-scute like-2 polypeptides and encoding nucleic acids and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... 05/24/07 - 20070117123 - Salivary protein and rna for breast cancer detection The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva. ... 05/24/07 - 20070117122 - Methods of diagnosing or prognosticating age-related macular degeneration A method for diagnosing or prognosticating age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said ... 05/24/07 - 20070117121 - Cdna library preparation New biochemical protocols for high throughput processing of mRNA samples into cDNA libraries with adaptor sequences compatible with automated sequencing systems are provided. The provided methods produces cDNA libraries which do not have 3′ bias associated with current cDNA library production methods. New methods for the production of DNA libraries ... 05/24/07 - 20070117120 - Mycoplasma detection method and composition A method of detecting the presence of mycoplasma in a sample and a mycoplasm detection kit. A sample is contacted with a first and a second oligonucleotide probe, wherein the first and second oligonucleotide probes are substantially complementary to portions of a 16S ribosomal subunit of at least one mycoplasma ... 05/24/07 - 20070117119 - Carriers having biological substance The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same. ... 05/24/07 - 20070117118 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117117 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117116 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117115 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one ... 05/24/07 - 20070117114 - Compositions and methods for increasing amplification efficiency Compositions and methods are provided that improve the specificity and efficiency of nucleic acid amplification. A binding partner may be bound to a DNA polymerase enzyme where the binding partner substantially inhibits the activity of the polymerase. A second enzyme modifies the binding partner in a manner that relieves the ... 05/24/07 - 20070117113 - Nucleic acid fragment encoding an nrps for the biosynthesis of anthramycin Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in ... 05/24/07 - 20070117112 - Materials and methods for the generation of fully 2'-modified nucleic acid transcripts Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence. ... 05/24/07 - 20070117111 - Microfabricated reactor, process for manufacturing the reactor, and method of amplification An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of ... 05/24/07 - 20070117110 - Flow cytometric detection method for dna samples Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR ... 05/24/07 - 20070117109 - Nanostructures, methods of making and using the same The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined structure. ... 05/24/07 - 20070117108 - Detection system for pcr assay The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridise to one another in free solution to form a fluorescent quenched pair, that upon introduction of a complementary sequence to one or both sequences ... 05/24/07 - 20070117107 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of ... 05/24/07 - 20070117106 - Identification and/or quantification method of nucleotide sequence (s) elements specific of genetically modified plants on arrays The present invention is related to an identification and/or quantification method of several organisms among many other ones possibly present in the analyzed sample having homologous sequence(s) by the determination of the genetic map of the organism. The method combines a limited number of amplifications of target sequence(s) using common ... 05/24/07 - 20070117105 - Interferon assay The present invention relates to methods and reporter cell assays for determining the ability of a patient sample to induce interferon target gene expression in interferon responsive cells. These methods will be useful for detecting, diagnosing, and monitoring those who have or are at risk of various autoimmune disorders or ... 05/24/07 - 20070117104 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117103 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117102 - Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. ... 05/24/07 - 20070117101 - Cleavable oligonucleotide arrays Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described. ... 05/24/07 - 20070117100 - Biomarker for determining predisposition and/or prognosis of hepatocellular carcinoma Disclosed herein are a method for determining predisposition to hepatocellular carcinoma (HCC) in a subject having or suspected to have a hepatic nodule, in particular one infected with at least one of hepatitis B virus and hepatitis C virus, and a method for prognostic evaluation of a subject having or ... 05/24/07 - 20070117099 - Process and apparatus for combinatorial synthesis Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for ... 05/24/07 - 20070117098 - 'signalin' family of tgfbeta signal transduction proteins and uses related thereto The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in a signal transduction induced by members of the TGFβ superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or ... 05/24/07 - 20070117097 - Novel proteins and novel genes encoding the same Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides are disclosed. The novel proteins are activated human macrophage-specific proteins. ... 05/24/07 - 20070117096 - Oscillating temperature capillary electrophoresis and uses therefor Methods for separating biomolecules using oscillating temperature electrophoresis are disclosed. Uses for such methods are also disclosed including high throughput screening, estimation of allele frequencies, identification of polymorphisms, and separation of DNA molecules. ... 05/24/07 - 20070117095 - Diagnostic method for neonatal or infantile epilepsy syndromes A method for the diagnosis of a neonatal or infantile epilepsy syndrome as BFNIS in a patient comprising testing for the presence of an alteration in the SCN2A gene, including in a regulatory region of the gene, in a patient sample, and establishing a diagnosis which will indicate a high ... 05/24/07 - 20070117094 - Support, printed material and reagent kit having enzyme fixed thereon, method for preparing the support, method of storing enzyme and method for restoration enzymes The invention enables enzymes to be stored in a simple manner. Disclosed are a support having an enzyme and a protecting agent for the enzyme fixed thereon; a printed material and a reagent kit comprising the support; a method for preparing the support; a method for restoring the enzyme fixed ... 05/24/07 - 20070117093 - Heavymethyl assay for the methylation analysis of the gstpi gene Described herein is a method for the detection of cyto-sine methylation in DNA samples, wherein the following steps are conducted: a genomic DNA sample, which comprises the DNA to be investigated as well as background DNA is treated with bisulfite (= disulfite, hydrogen sulfite) in such a way that all ... 05/24/07 - 20070117092 - Dna analysis system A DNA analysis system 10 includes a thermal cycler 12 operable as an extraction stage for extracting DNA from a sample to be tested and an as amplification stage for replicating identically a region of interest in DNA strands extracted from the sample. A predetermined proteinase is used in the ... 05/24/07 - 20070117091 - Anti-candida agents for the treatment of prion diseases The invention provides methods of treatment of prion disease, cancers and other conditions, the methods comprising administration of an anti-Candida agent. Also disclosed are methods of diagnosing prion disease and cancers, said methods based on the determination of the presence of Candida infection, in particular systemic candidiasis. ... 05/24/07 - 20070117090 - Processing nucleic acid The present invention relates to a method of processing nucleic acid. More particularly, it relates to a method of purifying extra-chromosomal DNA by removing cell debris and/or RNA from a process stream comprising extra chromosomal DNA and a precipitate resulting from preceding cell lysis and/or precipitation reactions. It also relates ... 05/17/07 - 20070111250 - Probe carrier, method of producing the probe carrier, method of evaluating the probe carrier and method of detecting a target nucleic acid using the same To provide probe carrier having a structure that a single-stranded DNA probe can be immobilized to a carrier effectively and forms of probe dots or spots immobilized to the carrier can be observed accurately by a scanning probe microscope or its derivative technology. A gold-containing film is formed in an ... 05/17/07 - 20070111249 - Automatic threshold setting for quantitative polymerase chain reaction Disclosed are systems and methods for identifying and quantitating the presence of one or more DNA species in a sample population through PCR amplification. DNA species quantitation includes a determination of a threshold fluorescence value used in the assessment of the PCR amplification reaction. Various embodiments of the present invention ... 05/17/07 - 20070111248 - Nucleotide sequences specific to francisella tularensis and methods for the detection of francisella tularensis Described herein is the identification of nucleotide sequences specific to Francisella tularensis that serves as a marker or signature for identification of this bacterium. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of ... 05/17/07 - 20070111247 - Systems and methods for the biometric analysis of index founder populations Systems, methods and apparatus for associating a clinical parameter with one or more candidate chromosomal regions in the human genome are provided. An index founder population is identified in a test population based upon the genotype X of each member of the test population such that the posterior probability Pr(K|X) ... 05/17/07 - 20070111246 - Parametric calibration method Method of preparing a calibration curve and determining the amount of an analyte polynucleotide present in a test sample, particularly using real-time amplification data. The method involves determining indicia of amplification for both the internal calibrator and analyte polynucleotide standards, each as a function of the amount of analyte polynucleotide ... 05/17/07 - 20070111245 - Predicting diabetic nephropathy The invention relates to methods and compositions for identifying subjects who are predisposed to having diabetic nephropathy (DN). ... 05/17/07 - 20070111244 - Tissue diagnostics for breast cancer Disclosed are methods for diagnosing breast cancer in a cell sample by detecting an increase in the levels of expression of protein markers in the cell sample as compared to the levels of expression of the same protein markers in a normal, nonneoplastic breast cell sample. Also disclosed is a ... 05/17/07 - 20070111243 - Detection of polyketide synthetase gene expression in karenia brevis The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the present invention ... 05/17/07 - 20070111242 - Method for producing novel dna sequences with biological activity A method of obtaining an oligonucleotide capable of carrying out a predetermined biological function. A heterogeneous pool of oligonucleotides, x+y+z nucleotides in length, is first generated. Each oligonucleotide has a 5′ randomized sequence, x nucleotides in length, a central preselected sequence, y nucleotides in length, and a 3′ randomized sequence, ... 05/17/07 - 20070111241 - System and method for accessing, tracking, and editing sequence analysis and software to accomplish the same The present invention relates to a system and method for accessing, tracking and editing sequence analysis and software to accomplish the same. The present invention includes embodiments that permit a party, for example a customer, to track the status of the samples (e.g., tissue, blood, or DNA) that the party ... 05/17/07 - 20070111240 - Cysteine variants of interleukin-11 and methods of use thereof Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications. ... 05/17/07 - 20070111239 - Methods of using il-21 An allelic variation in the IL-21 receptor can result in reduced IFN-γ production in individuals and can require administration of different doses of IL-21 to achieve therapeutic effects seen individuals that do not have the allelic variant. Based on the genotype of a patient's IL-21 receptor allele, methods of predicting ... 05/17/07 - 20070111238 - Methods for diagnosing and evaluating treatment of blood disorders Methods, systems and kits are provided for the clinical staging of blood disorders including myelodysplastic syndrome, myeloproliferative diseases and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or progenitor cell subsets. Additional functional, genetic, gene expression, proteomic or other molecular analyses of ... 05/17/07 - 20070111237 - Process for identifying antigenized antibodies using ribosome cell free expression system A process comprising (1) contacting a single-chain variable region (ScVr) mRNA library with a cell free ribosome expression system to produce a library of complexes each comprising a ribosome, an ScVr mRNA and a nascent single chain antigenized antibody encoded by the ScVr mRNA (ARM complexes) wherein the ScFv mRNA ... 05/17/07 - 20070111236 - Streptococcus suis vaccines and diagnostic tests The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derived thereof. The invention further provides ... 05/17/07 - 20070111235 - Detecting dna sequence variations A method of analysing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analysed. ... 05/17/07 - 20070111234 - Detection of biological dna The present invention provides a method, a kit and a system for the analysis of samples with respect to the presence of biological DNA based on real-time polymerase chain reaction (PCR) in combination with an analyzing step. The method comprises the steps of performing a universal real-time PCR to amplify ... 05/17/07 - 20070111233 - Prenatal diagnosis using cell-free fetal dna in amniotic fluid The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal ... 05/17/07 - 20070111232 - Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/17/07 - 20070111231 - Detection of mutations in a gene associated with resistance to viral infection, oas2 and oas3 Compositions and methods are provided for detecting a mutation in a human oligoadenylate synthetase gene, particularly OAS2 or OAS3, wherein the mutation confers resistance to flavivirus infection, including infection by hepatitis C virus, and the mutation relates to other disease states including prostate cancer and diabetes, and uses of the ... 05/17/07 - 20070111230 - Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/17/07 - 20070111229 - Pathogenicity determinants which can be used as targets for developing means for preventing and controlling bacterial infections and/or systemic dissemination The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising: using a strain of the pathogenic microorganism, generating mutants for inactivation in the genes encoding these factors, determining the virulence of these mutants on an expiremental model ... 05/17/07 - 20070111228 - Rna interference The present invention relates to RNA interference and methods for selecting interfering RNAs. The present invention also relates to modified interfering RNAs. The present invention also relates to methods of reducing the level of a specific mRNA in a cell, methods for reducing the level of a specific protein in ... 05/17/07 - 20070111227 - Small regulatory rnas and methods of use The present invention relates to unique small ribonucleic acid molecules, for example siRNAs and miRNAs, identified and isolated using MPSS. Specifically, the invention is directed to the identification of a library of unique small RNA sequences from Arabidopsis thaliana. In another aspect, the small RNA sequences themselves are useful for ... 05/17/07 - 20070111226 - Method to quantify sirnas, mirnas and polymorphic mirnas The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA ... 05/17/07 - 20070111225 - System and method for monitoring an analyte The present invention provides for a monitoring system and method to monitor an analyte, including determining the presence of the analyte and analyzing the analyte; for example, cellular chorography and biological threats. The system and method use a fluidics apparatus (e.g., a flow cytometer), a computer, a probe synthesizer and/or ... 05/17/07 - 20070111224 - Electrochemical sensor for detecting biomolecule, metthod of manufacturing the same, and method of detecting biomolecule using the same Provided is a sensor for detecting a biomolecule, which includes: a substrate; a first material, immobilized on the substrate, having a cavity structure; a secondary material capable of selectively binding to the cavity structure of the first material and having electrochemical activity; and a probe biomolecule immobilized to the secondary ... 05/17/07 - 20070111223 - Method for detecting disease-associated mutations A method is described for diagnosing individuals as having hypertrophic cardiomyopathy, e.g. familial or sporadic hypertrophic cardiomyopathy. The method provides a useful diagnostic tool which becomes particularly important when testing asymptomatic individuals suspected of having the disease. Symptomatic individuals have a much better chance of being diagnosed properly by a ... 05/17/07 - 20070111222 - Nucleic acid aptamer-based compositions and methods The present invention relates to compositions that can detect the presence of specific entities or substances in an environment, and provide an amplified response to the detection as manifested by release of enzymes, reporter signals or drugs. The detection and response is based on nucleic acid functionalities, such as aptamer ... 05/17/07 - 20070111221 - Method of preparation for pharmaceutical grade plasmid dna This invention provides a process for the continuous alkaline lysis of a bacterial suspension in order to harvest pDNA. It further provides for optional additional purification steps, including lysate filtration, anion exchange chromatography, triplex affinity chromatography, and hydrophobic interaction chromatography. These optional purification steps can be combined with the continuous ... 05/17/07 - 20070111220 - Sensing phage-triggered ion cascade (septic) The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within ... 05/17/07 - 20070111219 - Label integrity verification of chemical array data Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a sample assayed by chemical array analysis. A sample is divided into equal aliquots. At least first and second labels are incorporated into biopolymers contained in first and second aliquots of the equal aliquots, respectively. The ... 05/17/07 - 20070111218 - Label integrity verification of chemical array data Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a single sample assayed by chemical array analysis. At least first and second labels are incorporated into biopolymers in the single sample to produce a multi-labeled, single sample. The multi-labeled, single sample is hybridized with probes ... 05/17/07 - 20070111217 - Quantitative trait locus prognostic for changes in regional adiposity and bmi in caucasian males Caucasian males, but not females, presenting with statistically significant increases of L162V allelic SNP of the PPARα gene, relative to that of wild-type homozygotes, have an increased likelihood of increased regional adiposity (subcutaneous fat) and BMI, and are more likely to develop diseases associated with such changes, such as type ... 05/17/07 - 20070111216 - Methods for identifying polymerase inhibitors The present invention relates to methods and compositions for the identification of enzyme inhibitors. In particular, the present invention relates to the identification of nucleic acid polymerase inhibitors. ... 05/17/07 - 20070111215 - Customized oligonucleotide microchips that convert multiple genetic information to simpler patterns, are portable and reusable This invention relates to using customize oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals ... 05/17/07 - 20070111214 - 20685, 579,17114, 23821, 33894 and 32613, novel human transporters The present invention relates to newly identified human transporters. In particular, the invention relates to transporter polypeptides and polynucleotides, methods of detecting the transporter polypeptides and polynucleotides, and methods of diagnosing and treating transporter-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel ... 05/17/07 - 20070111213 - Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles The present invention describes primers, methods and kits for amplifying and identifying HLA alleles. Using these primers, all HLA alleles at a single locus can be amplified using either a multiplex or non-multiplex PCR approach. Within sets of the primers, control primer pairs may be used to produce control amplicons ... 05/17/07 - 20070111212 - Method of detecting nucleic acid and utilization thereof It is intended to provide a method of detecting a nucleic acid whereby a target nucleic acid can be accurately and quickly detected at an elevated detection sensitivity compared with the existing methods; and a gene detection kit with the use of this method. A sample containing cells is fixed ... 05/17/07 - 20070111211 - Integrated viral complexes, methods of production thereof, vaccines containing same and methods of use thereof Integrated viral complexes, methods of producing them, and their use as a vaccine against is described. Integrated viral complexes are optionally dried and may be stored at refrigeration temperatures. Integrated viral complexes include viable virions in intact cell membranes. The host cells are non-viable. The invention is advantageously employed in ... 05/17/07 - 20070111210 - Biomarkers for graft rejection Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed ... 05/17/07 - 20070111209 - Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders An association between psychiatric disorders and disorders comorbid with psychiatric disorders, and genetic markers in the 8p23 genomic region is described. Markers are also provided to diagnose or detect a susceptibility to disorders comorbid with panic disorder and independently of comorbidity with panic disorder. Methods and surrogate markers for detecting ... 05/17/07 - 20070111208 - Determination of free fractions The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmaco-logically active compounds in aqueous solutions and serum. The invention also relates to ... 05/17/07 - 20070111207 - Partially double stranded nucleic acid molecules A nucleic acid molecule for detecting a nucleic acid molecule is provided which is a partially double-stranded nucleic acid molecule consisting of (a) a single-stranded nucleic acid molecule complementary to the nucleic acid molecule to be detected and (b) one or two single-stranded nucleic acid molecules that hybridize with part ... 05/17/07 - 20070111206 - Method for diagnosis of tuberculosis by smear microscopy, culture and polymerase chain reaction using processed clinical samples and kit thereof The present invention relates to a method of processing clinical samples for diagnosing bacterial infections by smear microscopy, culture or PCR as well as a kit for performing the said method. This invention also pertains to two sets of primers specific for the DevR gene of M. tuberculosis as well ... 05/17/07 - 20070111205 - Detection of somatic cells in milk A simple, rapid and accurate method for detecting nucleic acids from milk are disclosed. The methods are useful in determining somatic cell count levels and diagnosing mastitis in cows. ... 05/17/07 - 20070111204 - Methods for detecting nucleic acid variations The invention provides methods and diagnostic test kits for detecting target nucleic acid sequence variations in a sample. In particular, a plurality of oligonucleotide probe sets is provided. Each set has a target specific portion and a barcode. The target specific portions of the probes are suitable for ligation together ... 05/17/07 - 20070111203 - Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. ... 05/10/07 - 20070105148 - Sphingosine 1-phosphate receptor gene, sppr A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases. ... 05/10/07 - 20070105147 - Rapid method for screening compounds for in vivo activity The present invention provides a rapid method for screening potentially pharmaceutically useful compounds for activity in vivo. The method has the steps of growing a target cell into which a reporter gene was introduced in a biocompatible, semipermeable encapsulation device; implanting the semi-permeable encapsulation device into a subject; administering a ... 05/10/07 - 20070105146 - Detection of susceptibility to autoimmune diseases The present invention provides methods and reagents for determining sequence variants present at the IL4 receptor, IL-4 and IL-13 loci, which facilitate identifying individuals at risk for type 1 diabetes. ... 05/10/07 - 20070105145 - Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... 05/10/07 - 20070105144 - Method of nucleic acid analysis It is intended to provide a method of efficient, high-precision quantitative analysis of a gene region with plural possible sequences by simultaneously separating and detecting standard and measurement nucleic acids overlapping in their detection times. The present invention provides a method of quantitative analysis of a gene region with plural ... 05/10/07 - 20070105143 - Novel bhlh type transcription factor genes Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily. ... 05/10/07 - 20070105142 - Methods for prognosis and monitoring cancer therapy The present invention also relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of HER-2, EGFR, VEGF, u-PA, p-PAI-1, and soluble forms thereof, ... 05/10/07 - 20070105141 - Use of azetidinone compounds The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents ... 05/10/07 - 20070105140 - In vivo production of cyclic peptides The present invention relates to methods and compositions utilizing inteins to generated libraries of cyclic peptides in vivo. ... 05/10/07 - 20070105139 - Fluorescent probe and fluorescence detecting method A fluorescent probe having a base sequence complementary to a specific sequence in a target nucleic acid, wherein the fluorescent probe has one end labeled with a nano particle fluorescent material, and the other end labeled with a fluorescent dye capable of fluorescence resonance energy transfer from the nano particle ... 05/10/07 - 20070105138 - Method for detection of a target nucleic acid with a fen nuclease The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of ... 05/10/07 - 20070105137 - Biomarkers for toxic algae The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can ... 05/10/07 - 20070105136 - Methods for identifying, diagnosing, and predicting survival of lymphomas Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis ... 05/10/07 - 20070105135 - Charged compounds comprising a nucleic acid binding moiety and uses therefor Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing ... 05/10/07 - 20070105134 - Efficacy of calcimimetic agents A method of assessing the efficacy of a calcimimetic drug to treat hyperparathyroidism in a subject may include determining which alleles for a calcium-sensitive receptor (CaSR) gene the subject carries; and concluding that the calcimimetic drug will have a first or highest efficacy if the subject has a 990Gly-990Gly genotype, ... 05/10/07 - 20070105133 - Compositions and methods for treating and diagnosing cancer The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor ... 05/10/07 - 20070105132 - Nucleic acid sequencing by raman monitoring of uptake of nucleotides during molecular replication The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake ... 05/10/07 - 20070105131 - Sequencing of surface immobilized polymers utilizing microfluorescence detection Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid ... 05/10/07 - 20070105130 - Compositions and methods for the treatment of cancer Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer. ... 05/10/07 - 20070105129 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection ... 05/10/07 - 20070105128 - Detection of genetic polymorphisms The present invention relates to genetic polymorphism data, compositions and methods for detecting genetic polymorphisms, methods for evaluating drugs using genetic polymorphisms and screening methods for drugs. ... 05/10/07 - 20070105127 - Method for producing modified glycoproteins Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower ... 05/10/07 - 20070105126 - Device for monitoring polymerase chain reactions A method for calibrating temperature can include cycling temperatures of a set of wells, wherein each well of the set comprises a sample with a spectrally distinguishable species. The method can further include measuring a signal from the spectrally distinguishable species for each well at a temperature during a first ... 05/10/07 - 20070105125 - Chemical array housing having a gas delivery element and methods of using the same Chemical array housings configured for use with chemical array readers are provided, where the housings include at least one chemical array holding element and a gas delivery element. Aspects of the invention include positioning a chemical array in the housing and introducing a gas into the housing. Also provided are ... 05/10/07 - 20070105124 - Methods and kits for nucleic acid amplification Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 05/10/07 - 20070105123 - Ire-1alpha substrates IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity. ... 05/10/07 - 20070105122 - Primers for synthesizing full-length cdna and their use Primers for synthesizing full-length cDNAs and their use are provided. 5602 cDNA encoding a human protein has been isolated and nucleotide sequences of 5′-, and 3′-ends of the cDNA have been determined. Furthermore, primers for synthesizing the full-length cDNA have been provided to clarify the function of the protein encoded ... 05/10/07 - 20070105121 - Method for the detection of schizophrenia related gene transcripts in blood The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation ... 05/10/07 - 20070105120 - Method of identifying/designing and/or modifying chemical species capable of interacting with a physiologically active macromolecule The present invention relates to a method of identifying/designing and/or modifying species capable of interacting with a protein molecule that is a potential drug target. ... 05/10/07 - 20070105119 - Method for detecting analytes by means of an analyte/polymeric activator bilayer arrangement The invention relates to the field of analytical sensors. In particular, the invention relates to a method for the detection of analytes in a sample by means of an electrode arrangement, which is characterized by the formation of a conductive bilayer of analytes and an agent for increasing the conductivity ... 05/10/07 - 20070105118 - Method for distinguishing aml subtypes with recurring genetic aberrations Disclosed is a method for distinguishing AML subtypes with recurring genetic aberrations t(8;21), t(15;17), t(11q23)/MLL, inv(3)/t(3;3), inv(l6), AML_komplext, trisomy 8 sole, trisomy 11 sole, trisomy 13 sole, monosomy 7 sole, del(5q) and/or del(9q) in a sample by determining the expression level of markers, as well as a diagnostic kit and ... 05/10/07 - 20070105117 - Method for in vitro evolution of polypeptides The invention relates to a method for the production and allocation of nucleic acids and polypeptides coded thereby. Said method can be used for evolutionary selection of polypeptides in vitro. The inventive method makes it possible to allocate nucleic acids to the polypeptides coded thereby and to select and isolate ... 05/10/07 - 20070105116 - Metal complex type nucleic acid An object of the present invention is to provide a novel structure that enables one-dimensional arraying of metal atoms and can stably exist. The present invention relates to a double-stranded oligonucleotide derivative, which contains two oligonucleotide derivatives each containing at least one nucleotide derivative wherein a base portion of a ... 05/10/07 - 20070105115 - Promoter of the human fatp5 gene and uses The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates ... 05/10/07 - 20070105114 - Biomarkers of cyclin-dependent kinase modulation Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates ... 05/10/07 - 20070105113 - Methods of degrading dsrna and synthesizing rna A protein having an activity of degrading a dsRNA, namely, being capable of acting on a long-chain dsRNA to form a dsRNA of a definite length; a method of efficiently preparing a dsRNA of a definite length which comprises treating a dsRNA with the protein having an activity of degrading ... 05/10/07 - 20070105112 - Laccases, nucleic acids encoding them and methods for making and using them The invention provides laccases, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention relates to the enzymatic production of nootkatone by way of the conversion of valencene using proteins having a laccase activity, e.g., a novel laccase of the invention. In one aspect, ... 05/10/07 - 20070105111 - Method for structuring a substrate surface In a method for structuring the surface of a substrate, a substrate is elastically expanded by the application of a tensile stress so that a surface area of the substrate in which a structure is to be created, is enlarged. Then, in the surface area, a structure is produced that ... 05/10/07 - 20070105110 - Mutation associated with strokes The present invention relates to a method of identifying a subject predisposed to ischemic stroke. The method includes the step of identifying a mutation in the subject that reduces the release rate of tissue plasminogen activator. ... 05/10/07 - 20070105109 - Sirt1 and genetic disorders Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity. ... 05/10/07 - 20070105108 - Polynucleotides capable of target-depedent circularization and topological linkage The invention provides allosterically regulatable polynucleotides capable of target-dependent circularization and topological linkage to a target nucleic acid molecule. Polynucleotides of the invention include a target binding sequence and a regulatory element which prevents circularization in the absence of the target binding. Polynucleotides may include a catalytic domain, allowing circularization ... 05/10/07 - 20070105107 - Marker assisted best linear unbiased prediction (ma-blup): software adaptions for large breeding populations in farm animal species The invention provides methodologies for improved molecular genetic analysis of individual animals and animal populations. The invention includes methods and systems for identifying those animals in a population that are most likely to heritably pass on desirable traits. Provided are means for evaluating the estimated breeding values and increasing the ... 05/10/07 - 20070105106 - Methods and reagents for quantitative analysis of dehalococcoides species The invention sets forth specific probes and primer pairs for such quantitative analysis and methods of obtaining template DNA from the Dehalococcoides species of interest. These techniques are useful in a bioremediation process to monitor and control the dechlorination of chlorinated hydrocarbons. ... 05/10/07 - 20070105105 - Surrogate cell gene expression signatures for evaluating the physical state of a subject The present invention relates to non-invasive and minimally invasive techniques for evaluating the physical state of a subject, including diagnosing a disease, disorder, or physical state of the subject, determining the prognosis of the subject, determining a subject's susceptibility for a disease, disorder, or physical state and determining, developing and ... 05/10/07 - 20070105104 - Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4) The invention provides a human LTB4 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of ... 05/10/07 - 20070105103 - Array having substances fixed on support arranged with chromosomal order or sequence position information added thereto, process for producing the same, analytical system using the array and use of these In fabricating various types of arrays such as a micro array, different kinds of biosubstances, or synthetic substances interacting with the biosubstances, are arranged and immobilized on a support such that the chromosomal order of base sequence blocks, corresponding to the biosubstances, is ascertainable. The biosubstances may be nucleic acids ... 05/10/07 - 20070105102 - Method for detection and characterization of pre-malignant transformation Methods are provided for estimating the risk of developing melanoma and related malignancies in an individual. Methods and compositions for diagnosing, treating, and preventing melanoma and related malignancies also are provided. ... 05/10/07 - 20070105101 - Gene expression associated with osteobla st differentiation The present invention identifies genes whose expression pattern is altered when pre-osteoblastic cells undergo differentiation into mature osteoblasts. The genes identified may be used as markers for the differentiation process. The present invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention ... 05/10/07 - 20070105100 - Process for assay of nucleic acids by competitive hybridization using a dna microarray A process for rapid and simple assay of nucleic acid on the basis of competitive hybridization using a DNA microarray that comprises a step of hybridizing a labeled nucleic acid other than the target nucleic acid with one of the immobilized probes on the substrate, where the labeled nucleic acid ... 05/10/07 - 20070105099 - Nucleic acid amplification using non-standard bases The present invention provides methods, kits and compositions for high fidelity nucleic acid amplification reactions of target nucleic acids such that specific amplification products that incorporate non-standard bases are produced. The amplification reactions can either be linear or exponential. In some embodiments, the fidelity of the amplification reaction is high ... 05/10/07 - 20070105098 - Isolation and use of ryanodine receptors The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial ... 05/10/07 - 20070105097 - Method for comparing gene expression level The present invention relates to a method for comparing and determining the gene expression level, which is very important in disease-related gene screening, early clinical diagnosis and medicine development. The present invention utilizes quantitative characteristics of bioluminescence analysis to compare gene expression levels of different individuals or samples in order ... 05/10/07 - 20070105096 - Endocrine cell lines and methods of using same In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or ... 05/10/07 - 20070105095 - Process for detecting predisposition to a cardiovascular disease Includes the identification in the genetic material of an isolated biological sample from said human an allelic variant which consist on the substitution of a cytosine by an tymine in the position 46 over the transcriptional origin of Factor XII (46C/T) within the locus of chromosome 5, limited by the ... 05/03/07 - 20070099230 - Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecles, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the ... 05/03/07 - 20070099229 - Marburg i mutant of factor vii activating protease (fsap) as risk factor for arterial thrombosis and methods of detecting fsap and fsap mutations A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described. ... 05/03/07 - 20070099228 - Concatameric ligation products: compositions, methods and kits for same The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form ... 05/03/07 - 20070099227 - Significance analysis using data smoothing with shaped response functions Methods, systems and computer readable media for analyzing data. A variable width window is applied to data points from the data which are ordered to correspond to locations along a chromosome of targeted nucleotide sequences whose relative abundances are represented by the data points. The window applied is a moving ... 05/03/07 - 20070099226 - Modified cyclic nucleotide gated ion channels The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments, regulation by Ca2+-calmodulin has been removed in the modified CNG channels. Convenient optical methods for detecting ... 05/03/07 - 20070099225 - Separation of chromosomes using an affinity-based magnetic bead separation in suspension A method for separating and isolating a target chromosome from a cellular sample by using a DNA probe with a fluorescein tag. Magnetic beads bound to anti-fluorescein isothiocyanate antibody were reacted with the fluorescently labeled pool of chromosomes and then separated in suspension by exposure to a magnetic field. ... 05/03/07 - 20070099224 - Slc1a1 marker for anxiety disorder The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A ... 05/03/07 - 20070099223 - Single nucleotide polymorphism associated with stroke susceptibility The present invention identifies various risk alleles, particularly a risk allele of SNP rs918592, within the PDE4D gene as novel stroke associated risk markers. These markers may be used for identifying a subject's susceptibility to stroke and diagnosing a subject's susceptibility to a particular type of stroke based on the ... 05/03/07 - 20070099222 - Methods and compositions for labeling nucleic acids The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include ... 05/03/07 - 20070099221 - Method of analyzing nucleic acid An object of the invention is to avoid any possibility of error caused by a nucleic acid used as a standard, a probe, or probe spot, etc. or enable correction thereof, to analyze the frequency of gene expressions with high reproducibility, and to analyze any change of primary structure in ... 05/03/07 - 20070099220 - Organic salt additives for nucleic acid amplification The present invention is directed to the use of a benzimidazolium compound comprising a side chain at at least one of its N-residues, said chain being either a Cn-alkyl or a substituted Cn-alkyl, characterized in that preferably n is ≧3, as an additive for a nucleic acid amplification reaction. ... 05/03/07 - 20070099219 - Systems and methods for treating, diagnosing and predicting the occurence of a medical condition Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on ... 05/03/07 - 20070099218 - Light transmitted assay beads A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling ... 05/03/07 - 20070099217 - Method for stress evaluation The molecular reaction mechanism that associates the clock gene with stress is elucidated based on the finding that stress is accompanied by an increase in the expression level of Per1 gene in peripheral tissues, stress response does not change the circadian rhythm in peripheral tissues, and Per1 gene increases in ... 05/03/07 - 20070099216 - Mutant endonuclease A novel mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but showing a specific activity. The present invention relates to a mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but having a specific activity, to a gene coding for the endonuclease V, to a ... 05/03/07 - 20070099215 - Novel bak binding protein, dna encoding the protein, and methods of use thereof The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to ... 05/03/07 - 20070099214 - Identification of a pin specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer The invention relates to nucleic acids encoding a mammalian ABCA5 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, PIN. Further, the invention relates to diagnostic assays for identifying the DNA-binding protein ABCA5 (also known as PIN-1). The invention ... 05/03/07 - 20070099213 - Corynebacterium glutamicum genes encoding novel proteins Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 05/03/07 - 20070099212 - Consecutive base single molecule sequencing The invention provides methods for sequencing polynucleotide molecules using single molecule sequencing techniques, where a plurality of labeled nucleotides are incorporated consecutively into an individual primer molecule. ... 05/03/07 - 20070099211 - Detection of nucleic acid amplification Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence ... 05/03/07 - 20070099210 - Methods of labelling polynucleotides with dibenzorhodamine dyes including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine ... 05/03/07 - 20070099209 - Compositions and methods for treating and diagnosing cancer The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem ... 05/03/07 - 20070099208 - Single molecule arrays for genetic and chemical analysis Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, ... 05/03/07 - 20070099207 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. ... 05/03/07 - 20070099206 - Compositions for detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include an RNA polymerase, a FEN nuclease, and a probe. ... 05/03/07 - 20070099205 - Compositions for detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions include a reverse transcriptase, a nuclease, an upstream primer and downstream probe. ... 05/03/07 - 20070099204 - Identification and quantification of a plurality of biological (micro)organisms or their components Disclosed is a system and method conducting real-time PCR. Capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is in ... 05/03/07 - 20070099203 - Biomarkers for neurodegenerative disorders The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the pattern of gene product expression from the sample to a library of gene ... 05/03/07 - 20070099202 - Methods and compositions for assessment of pulmonary function and disorders The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer. Nucleotide probes and primers, kits, and microarrays ... 05/03/07 - 20070099201 - Methods for detecting and quantifying binding and inhibition of binding of species to nucleic acids The invention features methods for detecting and quantifying the binding or inhibition of binding of species to biopolymers, e.g., nucleic acids. The invention is based on the use of probes that have magnetic relaxation properties that are affected by the presence of paramagnetic metal ions, e.g., Mn2+. Any class of ... 05/03/07 - 20070099200 - High throughput mobility shift The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and ... 05/03/07 - 20070099199 - Methods and compositions for treating cervical cancer The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid ... 05/03/07 - 20070099198 - Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provide methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts ... 05/03/07 - 20070099197 - Methods of prognosis of prostate cancer The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis ... 05/03/07 - 20070099196 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas The invention relates relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). ... 05/03/07 - 20070099195 - Methods and compositions for separating nucleic acids from a solid support Methods and compositions for separating nucleic acids from a solid support are provided. In the subject methods, a silica containing solid support having nucleic acids immobilized on a surface thereof is subjected to cleavage conditions, such that a fluid cleavage product that includes nucleic acids and silica is produced. The ... 05/03/07 - 20070099194 - Quality control of probe attachment on electrodes The present disclosure relates to methods of quantifying nucleic acid molecules immobilized on an electrode of an electrochemical assay chip. Such quantification can be used in testing and quality control of assay chips. Materials and instrumentation useful in performing such techniques are also disclosed. ... 05/03/07 - 20070099193 - Probe/target stabilization with add-in oligo The invention relates to analyzing a sample containing small RNAs. In exemplary embodiments, the sample is contacted with an array in the presence of an add-in oligo. In typical embodiments, probes on the array include regions that are complementary to small RNAs and regions that are complementary to the add-in ... 05/03/07 - 20070099192 - Denaturing size-fractionation in analysis of small rna The invention relates to analyzing a sample containing polynucleotides having small RNA binding sites. In exemplary embodiments, the sample is contacted with a size-fractionation medium under denaturing conditions to provide a fraction containing small RNA. The fraction containing small RNA is then contacted with an array under conditions sufficient to ... 05/03/07 - 20070099191 - Methods and systems for evaluating the length of elongated elements Systems and methods are disclosed for evaluating the length of elongated elements in a sample. The disclosed systems and methods may include using a direct current stimulus to determine a direct current base length region corresponding to at least a portion of the sample. Furthermore, the disclosed systems and methods ... 05/03/07 - 20070099190 - Method for distinguishing leukemia subtypes Disclosed is a method for distinguishing leukemia subtypes t(15;17), t(8;21), inv(16), inv(3), complex aberrant karyotype (CA), AML-MLL, normal karyotype (NK), AML-other (trisomy 8, trisomy 11, trisomy 13, monosomy 7, del(5q), del(9q), t(6;9); del(20q) and del(12p) and trisomy 4), ALL-MLL, ALL-Ph+, ALL-t(8;14), T-ALL, other B-lineage (OBL), CML, normal-BM, and/or CLL in ... 05/03/07 - 20070099189 - Method and apparatus for detecting substances or analytes from the analysis of one or more samples The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample ... 05/03/07 - 20070099188 - Novel method for finding mutations caused by the insertion of repeated dnas The present invention provides a method of for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations in a plant or mammalian subject. ... 05/03/07 - 20070099187 - Nucleic acid array A nucleic acid array is provided that can efficiently perform analysis, and further, can estimate the number of expressions of amino acid mutations for all cases by use of a smaller number of arrays. The nucleic acid array has a plurality of oligonucleotides immobilized on a substrate, wherein the oligonucleotide ... 05/03/07 - 20070099186 - Methods and means for the treatment of disorders associated with cellular senescence This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided ... 05/03/07 - 20070099185 - Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein The present invention provides methods for the screening and identification of agents from a large library of molecular structures that can alter the cleavage of amyloid precursor protein (AP). Agents identified by the methods of the present invention that modify the cleavage of APP can be used in the treatment ... 05/03/07 - 20070099184 - Nucleic acid amplication utilizing intermediate duplexes This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides (see FIGS. 1-7). ... 04/26/07 - 20070092909 - Molecular markers for identification of fat and lean phenotypes in chickens The invention provides molecular methods of screening chickens to determine those more likely to have a lean or fat phenotype by identifying the presence of at least one polymorphism in genetic material of a chicken in the thyroid hormone repressible gene (THRG) or its 3′ untranslated region (SEQ ID NO: ... 04/26/07 - 20070092908 - Renaturation, reassociation, association and hybridization of nucleic acid molecules The present invention features methods and compositions for the renaturation, hybridization, association, or reassociation of nucleic acids that combines both acceleration of the reaction rate and improved specificity. ... 04/26/07 - 20070092907 - Methods of screening compound probes Briefly described, embodiments of this disclosure include methods for identifying compound probe candidates, methods of screening compound probe candidates, methods of preparing molecular imaging probes, high throughput methods for identifying molecular imaging probes in a library, and the like. ... 04/26/07 - 20070092906 - Method and system for delivering nucleic acid into a target cell Controlled delivery of nucleic acid into adhered of cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complimentary DNA binding interactions with an oligonucleotide linker. ... 04/26/07 - 20070092905 - Compositions and methods for analyzing immobilized nucleic acids The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using ... 04/26/07 - 20070092904 - Method for preparing limiting quantities of nucleic acids The present invention relates generally to the amplification of nucleic acids. More specifically, the present invention facilitates amplification of total RNA for a variety of purposes, including analysis utilizing nucleotide assays, constructing cDNA libraries, in situ hybridization, and TaqMan. Additionally, the present invention facilitates amplification of total RNA isolated from ... 04/26/07 - 20070092903 - One-color microarray analysis methods, reagents and kits Microarray platforms for performing one-color and two color analyses using a single platform are provided. Methods of using the microarray platforms and analyzing data obtained from such microarrays are also provided. ... 04/26/07 - 20070092902 - Methods for detection of promoter polymorphism in ugt gene promoter The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon ... 04/26/07 - 20070092901 - Automated sample-to-microarray system An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a ... 04/26/07 - 20070092900 - Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer Methods and kits for diagnosing and characterizing breast cancer or a susceptibility to breast cancer are described herein. Diagnosis and characterization methods comprise detecting the BARD1 Cys557Ser allele or a haplotype comprising the BARD1 Cys557Ser allele in patients with or without a familial predisposition to cancer. The methods described herein ... 04/26/07 - 20070092899 - Multiple displacement amplification with blocker dna A method of whole genome amplification of a nucleic acid sample comprising providing a starting template of the nucleic acid sample, bringing the template together with blocking DNA, bringing the template together with DNA polymerase, and multiple displacement amplification of the template. The method can be used with a starting ... 04/26/07 - 20070092898 - Detection of multiple anti-viral antibodies The present invention relates to methods and kits for the diagnosis and monitoring of hepatitis C virus (HCV) infection and/or Kaposi's sarcoma herpesvirus infection (KSHV) in a subject, as well as other infectious diseases and agents. In particular, the present invention relates to the diagnosis and monitoring of infectious disease ... 04/26/07 - 20070092897 - Labeled probe bound object, method for producing the same and method for using the same A method for labeling an object, which is effective when multiple types of labels are given as necessary even to a very small object such as a fine particulate substrate for use in fixation of biological substances such as probe molecules or nucleic acid primers that are used for a ... 04/26/07 - 20070092896 - Extreme thermophile single-stranded dna binding mutant protein, and nucleic acid isothermal amplification method of use thereof The invention establishes a technology that allows non-specific amplification to be inhibited during nucleic acid amplification in an isothermal amplification reaction, such that the amplification efficiency is increased. The invention is a extreme thermophile single-stranded DNA binding mutant protein, having an amino acid sequence that expresses a function that can ... 04/26/07 - 20070092895 - Methods for identifying genes that increase yeast stress tolerance, and use of these genes for yeast strain improvement Disclosed are methods for identifying genes that increase stress tolerance of yeast, list of identified genes, and use of these genes for improving yeast strains for better survival and performance during ethanolic fermentation. ... 04/26/07 - 20070092894 - Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297. ... 04/26/07 - 20070092893 - Methods and compositions for identifying cancer-related biomarkers The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092892 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092891 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological ... 04/26/07 - 20070092890 - Methods and compositions for detecting autoimmune disorders The invention provides methods and compositions useful for detecting autoimmune disorders. ... 04/26/07 - 20070092889 - Parkinson's disease-related disease compositions and methods Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions. ... 04/26/07 - 20070092888 - Diagnostic markers of hypertension and methods of use thereof The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific ... 04/26/07 - 20070092887 - Methods for generating polynucleotides having desired characteristics by iterative selection and recombination A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to ... 04/26/07 - 20070092886 - Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease Polynucleotide sequences are provided that correspond to genes that are differentially expressed in atherosclerotic disease conditions. Methods for using these sequences to detect gene expression and/or for transcriptional profiling in mammals are also provided. The polynucleotide sequences of the invention may be used, for example, to diagnose atherosclerotic disease, to ... 04/26/07 - 20070092885 - Secreted proteins The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. ... 04/26/07 - 20070092884 - Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based dna library: application to the detection of mycobacteria A method for detecting Mycobacterium tuberculosis involves contacting a biological sample with the product of expression of at least one ORF contained in a polynucleotide present in Mycobacterium tuberculosis and absent in Mycabacterium bovis BCG; and detecting whether an immunological complex is formed between the product thereof and antibodies contained ... 04/26/07 - 20070092883 - Methylation specific multiplex ligation-dependent probe amplification (ms-mlpa) An improved multiplex ligation-dependent amplification method is disclosed for detecting the presence of specific methylated sites in a single stranded target nucleic acid, while simultaneously, the quantification of the target nucleic acid sequence can be performed, using a plurality of probe sets of at least two probes, each of which ... 04/26/07 - 20070092882 - Analysis of microrna Methods are described in which a sample containing miRNA is contacted with an array having a probe set, followed by interrogating the array to assess binding to the probe set. Probes, probe sets, arrays comprising a probe set, and kits incorporating the probe sets are also described. ... 04/26/07 - 20070092881 - Gene markers of tumor metastasis The invention concerns the study of tumor metastasis in a NOD/SCID/γcnull transgenic mouse model and the identification of tumor markers, including markers of tumors with high metastatic potential, using information obtained in this mouse model. ... 04/26/07 - 20070092880 - Invasive cleavage reaction with electrochemical readout A universal tag assay is disclosed wherein at least one invasive cleavage reaction (ICR) is used to generate tagged molecules having identifier tags corresponding to target nucleotide sequences, and further wherein hybridization of any tagged molecule with a complementary detection probe on a universal detector indicates the presence of the ... 04/26/07 - 20070092879 - Fluoresence-based dna primase assays The present invention provides methods for assaying the activity of DNA primases and methods for screening for compounds that modulate the activity of DNA primases. ... 04/26/07 - 20070092878 - In vitro method to detect bladder transitional cell carcinoma The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop ... 04/26/07 - 20070092877 - Bcrm-1 genes and uses thereof A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines ... 04/26/07 - 20070092876 - Method and system for cell and/or nucleic acid molecules isolation The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii) ... 04/26/07 - 20070092875 - Map2k6 as modifier of branching morphogenesis and methods of use Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided. ... 04/26/07 - 20070092874 - Plasma or serum marker and process for detection of cancer This disclosures provides, in one aspect, a method for detecting non-clinically diagnosed cancer in a patient. In one embodiment, the method includes extracting blood serum or plasma from the patient, and then detecting beta-catenin RNA in the blood serum or plasma. In addition, in this embodiment, the method includes determining ... 04/26/07 - 20070092873 - Digital identification of genetic materials and methods for acquiring data for it The present invention relates to methods using HIPK1 sequences for use in diagnosis and treatment of lymphoma and leukemia. In, addition, the present invention describes the use of these compositions for use in screening methods. ... 04/26/07 - 20070092872 - Apparatus and method for sequencing a nucleic acid Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides. ... 04/19/07 - 20070087379 - Ys68 gene involved in primitive hematopoiesis A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding ... 04/19/07 - 20070087378 - Polynucleotide and polypeptide fat metabolism regulators and uses thereof In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat ... 04/19/07 - 20070087377 - Methods and compositions for reverse translation A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse ... 04/19/07 - 20070087376 - Splice variants of pre-mrna transcripts as biomarkers in idiopathic neurodegenerative diseases The present invention discloses a method to discover biomarkers indicative of an idiopathic neurodegenerative disease in a mammalian subject and biomarkers indicative of an idiopathic neurodegenerative disease in the mammalian subject. The biomarker comprises a splice variant mRNA of a precursor-messenger RNA (pre-mRNA) transcript of a gene in the mammalian ... 04/19/07 - 20070087375 - Methods and compositions for treating cancer using 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to ... 04/19/07 - 20070087374 - Optimization of immunomodulatory properties of genetic vaccines This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose. ... 04/19/07 - 20070087373 - Optimization of immunomodulatory properties of genetic vaccines This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose. ... 04/19/07 - 20070087372 - Isolated ductal fluid sample A sample for diagnosis of breast cancer can be prepared by isolating a ductal fluid sample from one duct of a breast of a patient. The isolated ductal fluid is not mixed with ductal fluid from any other duct of the breast. Generally the target duct is not spontaneously discharging. ... 04/19/07 - 20070087371 - Zinc finger domains and methods of identifying same Disclosed is an in vivo selection method for identifying zinc finger domains that recognize any given target site. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites. ... 04/19/07 - 20070087370 - Microarray probe tm matching by selective destabilization Methods and systems for designing oligonucleotide probes for use in microarray applications are provided herein. The described methods use duplex melting temperature (Tm) matching to destabilize the hybridization oligonucleotide probes to non-target sequences as compared to a target nucleotide sequence. Nucleic acid arrays containing probes selected by the described methods ... 04/19/07 - 20070087369 - Method for the isolation of rna from biological sources Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding ... 04/19/07 - 20070087368 - Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants A system for analyzing alternative splice variant sequences is described, comprising an input manager for receiving alternative splice variant sequences that are identified by one or more probe sets, a correlator that correlates functional domains with each of the alternative splice variant sequences and an associater that associates putative functions ... 04/19/07 - 20070087367 - Method and apparatus for combinatorial chemistry A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be ... 04/19/07 - 20070087366 - Functional mutant loxp sequences and uses thereof The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different ... 04/19/07 - 20070087365 - Methylation markers for diagnosis and treatment of ovarian cancer Twenty-three markers are provided which are epigenetically silenced in ovarian cancers. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor-suppressor ... 04/19/07 - 20070087364 - In vitro erythroid micronucleus assay for genotoxicity The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro. ... 04/19/07 - 20070087363 - Therapeutic methods, compounds and compositions The invention provides methods of treating, preventing, delaying the onset, slowing the progression, or reversing the symptoms of Alzheimer's disease and other neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide. The invention also provides compounds that reduce the production or secretion of the Aβ42-peptide by ... 04/19/07 - 20070087362 - Polony fluorescent in situ sequencing beads Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided. ... 04/19/07 - 20070087361 - Solid support assay systems and methods utilizing non-standard bases Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target ... 04/19/07 - 20070087360 - Methods and compositions for detecting nucleotides The present teachings generally relate to methods and materials for the detection of target nucleotides and/or the methylation state of target nucleotides. ... 04/19/07 - 20070087359 - Detecting mutations in the feline cardiac myosin binding protein c gene associated with hypertrophic cardiomyopathy in cats The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy in cats, particularly domesticated cats, and more particularly Maine Coon cats. The methods include detecting the presence or absence of a mutation in the feline MYBPC gene, and identifying feline subjects that ... 04/19/07 - 20070087358 - Methods for diagnosing cancer based on dna methylation status in nbl2 The present invention relates to methods for diagnostic or prognostic assay for cancer based on analysis of altered methylation status at specific CpG dinucleotide sequences within the epigenetic marker, NBL2. The methods of the invention comprise determining the methylation status of a subregion of genomic CpG dinucleotide sequences within the ... 04/19/07 - 20070087357 - Lateral flow device with onboard reagents Devices, methods and kits for conducting an assay to determine the presence or amount of an analyte in a fluid sample. The device includes a sample application element and a flow path matrix that facilitates fluidic flow by capillary action. The sample application element includes a non-absorbent or absorbent carrier ... 04/19/07 - 20070087356 - In situ assembling of protein microarrays The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds ... 04/19/07 - 20070087355 - Comparative genomic hybridization assays and compositions for practicing the same Comparative genomic hybridization (CGH) assays and compositions for use in practicing the same are provided. Aspects of the methods include first preparing genomic templates from an initial genomic source by using precursors of circular template nucleic acids, e.g., padlock probes. The precursors include first and second domains that are at ... 04/19/07 - 20070087354 - Lentiviral vector-based vaccine Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed. ... 04/19/07 - 20070087353 - Microarray biochemical reaction device The microarray biochemical reaction device of this invention integrates microfluidic trenches with a microarray to form a serpentine microchannel passing through all DNA probes provided in the microarray. A sample solution is introduced into the microchannel and scrambled into discrete plugs to induce droplet mixing. The discrete plugs are then ... 04/19/07 - 20070087352 - Inhibitors for androgen antagonist refractory prostate cancer The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed ... 04/19/07 - 20070087351 - Orotate transporter encoding maker genes A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a ... 04/19/07 - 20070087350 - Use of a mutation in the braf gene for the determination of the malignancy of melanoma cells The invention relates to the use of oligonucleotide probes comprising exon 15 of the BRAF gene or a part thereof comprising codon 599 for the detection of the malignancy of melanoma cells. ... 04/19/07 - 20070087349 - Highly parallel template-based dna synthesizer The invention relates to a template-based method for preparing nucleic acid double strands. ... 04/19/07 - 20070087348 - System and method for carrying out multiple binding reactions in an array format A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at ... 04/19/07 - 20070087347 - Dose-dependent promoter originating in humans It was found that a DNA consisting of a nucleotide sequence as set forth in SEQ ID NO: 1 having one sequence (SEQ ID NO: 2) unit, has a function of an initiator or a promoter. Therefore, it is provided a DNA consisting of a nucleotide sequence as set forth ... 04/19/07 - 20070087346 - Orthogonal gene switches The present invention relates to an orthogonal gene switch for regulating the expression of a desired gene. The gene switch comprises a chimeric transcription factor that does not respond to endogenous ligands, and a ligand that is capable of activating the chimeric transcription factor but not endogenous transcription factors. The ... 04/19/07 - 20070087345 - Assays for the direct measurement of gene dosage The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy. ... 04/19/07 - 20070087344 - Methods for characterizing signaling pathways and compounds that interact therewith The genes in a signaling pathway can be identified by over or under-expressing each member of a set of genes to be grouped in signaling pathways and measuring parameters under stimulatory conditions. Genes in a common signaling pathway give similar parameter profiles under such conditions. Moreover, the interactions between signaling ... 04/19/07 - 20070087343 - Method of detecting gene expression and kit and apparatus to be used therein In an animal embryo or tissue, the following wholeamount treatment is carried out so that gene expression is detected. First, a sample such as an embryo or a tissue is fixed and then pretreated by acetylating an amine with acetic anhydride and eliminating lipids by using xylene. Next, in situ ... 04/19/07 - 20070087342 - Secreted proteins The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. ... 04/12/07 - 20070082361 - Dna and proteins or peptides specific of bacteria of the neisseria meningitidis species, methods for obtaining them and biological applications thereof The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp ... 04/12/07 - 20070082360 - Magnetic pigment Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification. ... 04/12/07 - 20070082359 - Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay Methods of identifying a compound that inhibit, enhance and/or misdirect assembly of a viral capsid include providing fluorescently-labeled capsid polypeptides labeled with a fluorescent dye that changes fluorescence at high concentration, wherein assembly of the capsid polypeptides into the viral capsid results in juxtaposition of at least one of the ... 04/12/07 - 20070082358 - Sequencing by synthesis based ordered restriction mapping The present invention is directed to a method for de novo assembly of genomic sequence information comprising the combination optical whole genome restriction mapping and ultra high throughput pyrosequencing. ... 04/12/07 - 20070082357 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan; and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive ... 04/12/07 - 20070082356 - Methods of evaluating transplant rejection The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell ... 04/12/07 - 20070082355 - Method for polymerase chain reactions with use of a dna polymerase with proofreading properties The present invention concerns a method for a polymerase chain reaction, in which a template nucleic acid, at least one primer, deoxyribonucleoside triphosphates as well as a DNA polymerase with proofreading activity are used. In addition, according to this invention, at least one target substrate is added to the polymerase ... 04/12/07 - 20070082354 - method for isolating rna A method for isolating RNA from RNA containing samples wherein the RNA containing sample is treated with at least one DNase and/or another enzyme like proteases or collagenases for purification of RNA in presence of a complex of ribonucleosides and the oxovanadyl ion which is capable of inhibiting RNases present ... 04/12/07 - 20070082353 - Genetic marker selection program for genetic diagnosis, apparatus and system for executing the same, and genetic diagnosis system There is provided a marker selection program for selecting a marker for use in genetic diagnosis. In the program, analysis is carried out by using at least two specimen databases which respectively store data of specimens belonging different populations. By carrying out analysis without integrating all specimen data into single ... 04/12/07 - 20070082352 - Microscopy tip Disclosed is a tip for use in atomic force microscopy. The tip includes a substrate and a three-dimensional, double-stranded nucleic acid structure attached thereto. The nucleic acid structure may have a single-stranded nucleic acid attached thereto, such as an aptamer sequence. In use, the tip having the nucleic acid structure ... 04/12/07 - 20070082351 - Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy ... 04/12/07 - 20070082350 - Assay and method for diagnosing and treating alzheimer's disease I Methods and kits for diagnosing Alzheimer's disease and/or incipient Alzheimer's disease are disclosed. The methods and kits of the invention utilize a set of genes and their encoded proteins that are shown to be correlated with incipient Alzheimer's disease. ... 04/12/07 - 20070082349 - Photocrosslinking probes and uses of the same A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products ... 04/12/07 - 20070082348 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 04/12/07 - 20070082347 - Gene variants and use thereof Variants in TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 and AMFR genes are disclosed which are useful as biomarkers for predicting the TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 or AMFR gene ... 04/12/07 - 20070082346 - Homogeneous detection method The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is ... 04/12/07 - 20070082345 - Secretory protein or membrane protein Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides ... 04/12/07 - 20070082344 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 04/12/07 - 20070082343 - Method for the control of segment-wise enzymatic duplication of nucleic acids via incomplete complementary strands The invention relates to a new method for the control of enzymatic duplication of nucleic acids by the section via incomplete complementary strands. Fields of application of the invention are research, medical practice, gene-based analytics of biotechnological, agricultural and foodstuff products as well as criminology. ... 04/12/07 - 20070082342 - Near-patient module for analyte detection system In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The ... 04/12/07 - 20070082341 - Human phospholipases The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME. ... 04/12/07 - 20070082340 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for ... 04/12/07 - 20070082339 - Methods and compositions for screening for hdac inhibitory activity The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a ... 04/12/07 - 20070082338 - Cgh array quality assessment Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across ... 04/12/07 - 20070082337 - Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced ... 04/12/07 - 20070082336 - Methods for protein labeling based on acyl carrier protein A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof. ... 04/12/07 - 20070082335 - Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction The invention provides methods and compositions based on the interaction of TSG101 and VPS28 proteins for treatment of viral infections, including HIV infections. The invention also provides TSG101-VPS28 based methods and compositions for evaluation and screening of drugs which can be used for treating viral infections. ... 04/12/07 - 20070082334 - Nucleotide and protein sequence of mammastatin and methods of use A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and ... 04/12/07 - 20070082333 - Thermophilic dna polymerases from thermoactinomyces vulgaris The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, ... 04/12/07 - 20070082332 - Molecular cardiotoxicology modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of ... 04/05/07 - 20070077591 - Novel polypeptide A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed. ... 04/05/07 - 20070077590 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of ... 04/05/07 - 20070077589 - Altered recombinases for genome modification The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also ... 04/05/07 - 20070077588 - Non-fluorescent energy transfer The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these donor moieties typically entail reduced background fluorescence relative to applications that involve conventional fluorescent donor moieties. In addition ... 04/05/07 - 20070077587 - Method of detecting a biopolymer and device for the same Provided is a method of achieving a simple, quick, and highly accurate detection and measurement of a biopolymer, and to provide a device for this purpose. To this end, a method of detecting a biopolymer utilizing two kinds of solvent phases different in property from each other, including steps of: ... 04/05/07 - 20070077586 - Maternal chelation for embryo, fetal, and infant benefit This invention teaches the use of chelating agents to diagnose and treat metal toxins in a patient. Chelation agents are given to the mother for the benefit of the baby. Metal toxins such as lead, arsenic, mercury, tin, antimony, aluminum and others are known to cause miscarriages, birth defects, maldevelopment ... 04/05/07 - 20070077585 - Compositions and methods for il13 biomarkers Compositions and methods are provided for measuring and determining biomarkers for IL-13. ... 04/05/07 - 20070077584 - Adenovirus status as a predictor of body composition change, disease status, and treatment outcomes Infection with obesifying adenoviruses in animals and humans may be used to predict changes in body weight and disease status. More particularly, infection with certain adenoviruses, such as adenovirus type 36 (Ad-36) and adenovirus type 37 (Ad-37) may cause removal of the normal equilibrium factors that control fat cell metabolism ... 04/05/07 - 20070077583 - Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance Disclosed are methods for detecting a neoplasm and/or chemotherapeutic drug resistance or angiogenic potential in neoplastic cells by detecting an increase in the expression of α-enolase in such cells, or in the case of metastatic potential on the surface of such cells, as compared to the level of expression of ... 04/05/07 - 20070077582 - Method for quantitative detection of short rna molecules Described herein are approaches to the detection and quantitation of short RNAs in a biological sample. The methods permit the detection and quantitation of individual species of short RNA in a nucleic acid sample, both singly and in a multiplex format that permits the determination of expression levels for two ... 04/05/07 - 20070077581 - Oncoprotein protein kinase An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and Threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of deterction of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects ... 04/05/07 - 20070077580 - Biochemical treatment apparatus and method comprising liquid handling mechanism Nucleic acid solution, magnetic particles solution and primer or eluate are moved between a lot of wells provided in reaction/storage vessel 3 by pipette device 40 to perform the first PCR, purification and the second PCR. In the time point where the first PCR and purification end, pipette tip 42 ... 04/05/07 - 20070077579 - In vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements ... 04/05/07 - 20070077578 - Diagnosis of (a risk of ) disease and monitoring of therapy The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from the individual comprises an expression product of AC133 in ... 04/05/07 - 20070077577 - Proliferation markers in clinical practice and their use for cancer prognosis or diagnosis The invention relates to a method for assessing the proliferative state of cells in a human or non human biological sample, comprising using Chromatin Assembly Factor-1 (CAF-1 in short) subunits as proliferation markers. Application for cancer prognosis or diagnosis and monitoring tumor response in therapy. ... 04/05/07 - 20070077576 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 04/05/07 - 20070077575 - Use of rna polymerase as an information-dependent molecular motor Materials and methods are described in which the information dependence of RNA polymerase is employed to enable its use as a molecular motor adaptable for movement within DNA grid arrays and to actuate, move, position or alter cargo such as physical structures and normally inanimate substances and objects. ... 04/05/07 - 20070077574 - family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and ... 04/05/07 - 20070077573 - Method for extracting dna from sample of organism A method in which DNA is extracted from a precious sample of organism simply and efficiently without being contaminated by impurities is provided. The method for extracting DNA comprises of: 1) a process for pretreatment having; a procedure for obtaining fragments by using a whole sample of organism of hard ... 04/05/07 - 20070077572 - Compositions and methods for in vitro sorting of molecular and cellular libraries The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulsion includes a continuous ... 04/05/07 - 20070077571 - Methods and apparatus for identifying allosterically regulated ribozymes Compositions and methods are provided to use regulatable aptazymes for controlling gene expression and in assays to detect the presence of ligands or to detect activation by an effector of an aptazyme bound to a solid support such as a substrate or multi-well plate. Regulatable aptazymes are ribozymes that are ... 04/05/07 - 20070077570 - Multiplexed amplification of short nucleic acids The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of a zip-coded stem-loop reverse transcription primer, along with a PCR-based pre-amplification reaction that comprises a zip-coded forward primer. Detector probes ... 04/05/07 - 20070077569 - Isomaltulose synthases, polynucleotides encoding them and uses therefor The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and ... 04/05/07 - 20070077568 - Process for preparing high stability, high activity coatings and processes for using same A process for preparing high stability, high activity biocatalytic coatings is disclosed attachable to various materials and fibers, and processes for using same. The process involves attaching crossslinked enzyme aggregates to various materials and fibers forming a biocatalytic coating characterized by high biocatalytic activtity and high stability. The coated materials ... 04/05/07 - 20070077567 - High stability, high activity materials and processes for using same The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high biocatalytic activity and stability useful in heterogeneous environment. These new materials provide a new biocatalytic immobilized enzyme system with applications in bioconversion, bioremediation, biosensors, ... 04/05/07 - 20070077566 - High stability, high activity coatings and processes for using same The present invention relates to a high stability, high activity coating and processes for using the same. The coating has high biocatalytic activity and stability useful on surface of various materials and fibers, e.g., polymer fibers applicable in heterogeneous environments. In one illustrative approach, enzyme “seed” are covalently attached to ... 04/05/07 - 20070077565 - Process for preparing high stability, high activity materials and processes for using same A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and enzyme aggregate providing a material or fiber with high biocatalytic activity and stability useful in heterogeneous environments. In one illustrative ... 04/05/07 - 20070077564 - Reactive surfaces, substrates and methods of producing same Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses. ... 04/05/07 - 20070077563 - Method of searching for functional nucleotide molecule A universal method of searching for a nucleic acid capable of effectively inhibiting gene expression; a nucleic acid construct to be used in this method; a vector; and a kit for the above method. This method is characterized in that a nucleic acid construct, which is a nucleic acid construct ... 04/05/07 - 20070077562 - Rapid nucleic acid isolation method and compositions A method of isolating RNA from a biological specimen is provided, whereby a biological specimen is contacted with an admixture of (i) a mono-phasic solution of phenol and guanidine isothiocyanate and (ii) a lysis buffer under conditions and for a time appropriate to form a homogenate. Next, the homogenate is ... 04/05/07 - 20070077561 - Detection of transgenes of genetically modified organisms using pyro luminescence The present application provides a method for identifying the presence of a transgene of a genetically modified organism in a sample wherein the nucleic acid sequence of the transgene is replicated and detected as the release of PPi from the deoxynucleotide triphosphate precursors consumed in the replication reaction. This pyro ... 04/05/07 - 20070077560 - Method and system for rapidly conferring a desired trait to an organism A method is provided for regulating the conversion rate of a hereditary trait of a cell, comprising the step of regulating the error-prone frequency of gene replication of the cell. A method is provided for producing a cell having a regulated hereditary trait, comprising the step of (a) regulating an ... 04/05/07 - 20070077559 - Newcastle disease virus administration A mammalian subject having a tumor is treated by a method comprising administering an effective amount of a Newcastle disease virus, wherein the virus is administered to the subject in one or more cycles; and at least one cycle comprises administering sequentially one or more initial doses of from 1.8×1010 ... 04/05/07 - 20070077558 - Method for evaluating quality of beef such as taste and texture on the basis of genotype of stearoyl-coa desaturase We paid attention to stearoyl-CoA desaturase gene, and investigated the relation between this gene and the unsaturated fatty acid content in beef fat. As a result, we found that the unsaturated fatty acid content was associated with the genotype of this gene, classified according to several single nucleotide polymorphisms (SNPs) ... 04/05/07 - 20070077557 - Method for identifying type-1 interferon responsive ms patients by determining trail expression This invention relates to a method for identifying MS patients susceptible to type I-Interferon (IFN), in particular IFN-β, and for monitoring IFN therapy in MS patients by determining TRAIL gene and/or protein expression as a marker. ... 04/05/07 - 20070077556 - Tumor associated antigens and methods of using the same The present invention provides methods and compositions for the diagnosis of hyperproliferative disease and autoimmune disease. Tumor associated antigens, nucleic acids encoding them and antibodies to the tumor associated antigens are provided for the diagnosis of hyperproliferative disease, such as, for example, ovarian cancer, breast cancer, lung cancer, colorectal cancer, ... 03/29/07 - 20070072233 - Methods and systems for facilitating the diagnosis and treatment of schizophrenia A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy). ... 03/29/07 - 20070072232 - Identification of genetic components of drug response The present invention is concerned generally with the field of identifying an appropriate treatment regimen for a disease based upon genotype in mammals, particularly in humans. It is further concerned with the genetic basis of inter-patient variation in response to therapy, including drug therapy. Specifically, this invention describes the identification ... 03/29/07 - 20070072231 - Tumor suppressor gene A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells ... 03/29/07 - 20070072230 - Compositions, kits, and methods relating to the human fez1 gene, a novel tumor suppressor gene The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, ... 03/29/07 - 20070072229 - Method for isolation, amplification and quantitation of ribonucleic acid A cellular RNA isolation method comprising treating at least one nucleated cell with a composition comprising mild detergents such as non-ionic detergent(s), buffer(s), chelator(s), reducing agent(s), salt(s), and RNase inhibitor(s) to result in a cytoplasmic lysate and intact nucleus, then separating the cytoplasmic lysate containing RNA from the nucleus, and ... 03/29/07 - 20070072228 - Ercc2 polymorphisms This invention relates to diagnostic methods based upon a polymorphism in individuals indicative of an increased risk of breast carcinoma. More specifically, this invention relates to a method for diagnosis of an increased risk of breast carcinoma by screening for the presence of genetic polymorphisms in individuals, specifically in the ... 03/29/07 - 20070072227 - Gamma secretase notch biomarkers The present invention relates to biomarker indicators, including polypeptides, polynucleotides and small molecules, that measure γ-secretase mediated Notch processing. These indicators have utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized ... 03/29/07 - 20070072226 - Mining protein interaction networks One embodiment is a method including creating a protein interaction network including a plurality of protein IDs and a plurality of interactions between protein IDs, determining confidences of interactions of the protein interaction network, identifying a sub-network of the protein interaction network, and determining relevance of proteins of the sub-network ... 03/29/07 - 20070072225 - Antibodies with simultaneous subsite specificities to protein and lipid epitopes Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars ... 03/29/07 - 20070072224 - Diagnosis and treatment of tumor-suppressor associated disorders Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSLC1 and detecting the level of TSLC1 in the proliferating cell. TSLC1 is a single gene whose expression is reduced ... 03/29/07 - 20070072223 - Compositions and methods for purifying nucleic acids Described herein are compositions and methods for enriching a nucleic acid sample for target sequence(s). The compositions comprise an oligonucleotide attached to a solid support, directly or indirectly, wherein the oligonucleotide does not serve as a primer for a polymerase enzyme. ... 03/29/07 - 20070072222 - Fabp4 as biomarker for toxic effect The present invention relates to FABP4 as a marker for determining at least one toxic effect of a compound of interest and methods for determining same. ... 03/29/07 - 20070072221 - Methods to screen peptide display libraries using minicell display A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size ... 03/29/07 - 20070072220 - Non-fouling polymeric surface modification and signal amplification method for biomolecular detection An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first ... 03/29/07 - 20070072219 - Detection method of homologous sequences differing by one base on a microarray The present invention is related to a detection method and kit of homologous sequences differing by one base on a microarray. ... 03/29/07 - 20070072218 - Tumor suppressor killin The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies. ... 03/29/07 - 20070072217 - Xaf genes and polypeptides: methods and reagents for modulating apoptosis The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis. ... 03/29/07 - 20070072216 - Method for diagnosis of glioma: distinguishging between progressive and de novo types The present invention relates to a method for identifying the type of glioblastoma multiforme in mammals, preferably human subjects. More particularly, it relates to a kit for characterizing progressive glioma in mammals, preferably human subjects. More particularly, it relates to a kit for distinguishing primary and secondary glioblastoma multiforme (GBM) ... 03/29/07 - 20070072215 - Nucleic acid-based logic circuits This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein. ... 03/29/07 - 20070072214 - Detection of truncation mutations by mass spectrometry This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference. ... 03/29/07 - 20070072213 - Method and apparatus for implementing non-destructive quality control of substrates and printed biological microarrays, and for implementing quality control and visualizing gel-based microarrays prepared by dispensing gel-forming composition on solid surf A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of ... 03/29/07 - 20070072212 - Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material The use of artificially-generated nucleic acid coded markers to monitor nucleic acid amplification and sequencing reactions designed to detect or analyze biological samples. The markers generally include, along with a unique sequence preferably including coded section designed to represent one or more factors of interest, primer annealing sequences so that ... 03/29/07 - 20070072211 - Asymmetric pcr coupled with post-pcr characterization for the identification of nucleic acids The present invention provides methods, compositions, and kits for quantification and identification of target nucleic acid sequences, either in pure solutions or from mixtures of various nucleic acids. In other aspects, the invention provides compositions and methods for HCV genotyping. ... 03/29/07 - 20070072210 - Use of brca1-associated protein to treat and screen for dna damage and to identify therapeutics that promote a dna damage response The present invention relates to the use of a BAAT1 protein to screen for potential therapeutics that promote a DNA damage response or treat breast cancer. The present invention also relates to a method of treating DNA damage or breast cancer in a subject by administering a compound that increases ... 03/29/07 - 20070072209 - Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases Aspects of the present invention use gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the ... 03/29/07 - 20070072208 - Nucleic acid analysis by random mixtures of non-overlapping fragments The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such ... 03/29/07 - 20070072207 - Production of vaccines Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing ... 03/29/07 - 20070072206 - Strong pcr primers and primer cocktails The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of diverse sequences in chaperonin-60 based PCR product libraries derived from complex templates. In previous cpn60-based and 16S rDNA-based studies of ... 03/29/07 - 20070072205 - Nanomaterial error correction The present invention makes use of the discovery that proofreading and error-correction techniques common in biological systems may be adapted to material science. Enzymes and aptamers are adapted to proofread and correct defects in nanoparticle structures. ... 03/29/07 - 20070072204 - Compositions and methods for cancer diagnosis and treatment The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy. ... 03/29/07 - 20070072203 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed. ... 03/29/07 - 20070072202 - Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an ... 03/29/07 - 20070072201 - Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results An approach and methods are provided for obtaining improved information and results concerning the functional homogeneity and functional characteristics of a chemically synthesized or biologically synthesized nucleic acid oligomer of any type, and for obtaining improved information and results concerning the functional homogeneity and functional characteristics of the oligomer under ... 03/29/07 - 20070072200 - Method for determining co-receptor selectivity of human immunodeficiency virus-1 Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop ... 03/29/07 - 20070072199 - Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces The present invention is directed to methods for immobilizing molecules on siliceous and metallic surfaces. Molecules are immobilized on siliceous or metallic surfaces by stable covalent linkages that are capable of withstanding prolonged use and elevated temperatures. Further, the methods of the present invention describe less-complicated chemistries for the immobilization ... 03/29/07 - 20070072198 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds. ... 03/29/07 - 20070072197 - Microtags for detection and identification of materials A customized microtag identifier has a custom synthesized polynucleic acid having a known sequence of bases, a recovery compound, and a protective coat; effective to identify said custom synthesized polynucleic acid, ... 03/29/07 - 20070072196 - Fluorescent nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others. ... 03/29/07 - 20070072195 - Bio-commemorative article incorporating amplified genetic material A combination of amplified genetic material from an individual or other organism with an inanimate article of manufacture to produce a bio-commemorative article is disclosed. The amplified genetic material is preferably produced from a polymerase chain reaction process. The amplified genetic material is coated onto the inanimate article of manufacture, ... 03/29/07 - 20070072194 - Global transcription machinery engineering The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. ... 03/29/07 - 20070072193 - Ligand arrays having controlled feature size, and methods of making and using the same Methods and compositions for producing a solid support having a ligand immobilized on a surface thereof, e.g. a ligand array, are provided. Aspects of the methods include: providing a solid support having a bounded feature location on a surface thereof, where the bounded feature location includes a region of the ... 03/29/07 - 20070072192 - Novel polypeptides encoded by essential bacterial genes The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides. ... 03/29/07 - 20070072191 - Infectious pestivirus pseudo-particles containing functional erns, e1, e2 envelope proteins The invention relates to the generation and the use of pestivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto retroviral core particles. These particles are highly infectious and constitute a valid model of pestivirus virion. ... 03/29/07 - 20070072190 - System and method for universal identification of biological humans A system and method for uniquely identifying each human being and generate a Universal Identification Number (UIN) to aid tracking. UIN database comprises of public, health, and confidential information. The number issued for display on UIN Identity Card and used for accessing data on-line protects privacy of the individual by ... 03/29/07 - 20070072189 - Artificial mutation controls for diagnostic testing Disclosed are artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular mutation. Also provided are methods of generating such compositions, and ... 03/29/07 - 20070072188 - Methods for detection of mycobacterium tuberculosis The present invention provides an oligonucleotide primer pair having SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of Early Secretory Antigenic Target (esat)-6-gene of Mycobacterium species. The invention also provides a method for detecting M .tuberculosis in a sample based on the amplification of esat-6 gene, comprising ... 03/29/07 - 20070072187 - Novel methods and apparatus for cell based microarray assays The present invention relates methods for screening of cellular responses comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels (b) providing cellular components on said first and/or second surface of said solid porous support, wherein said ... 03/29/07 - 20070072186 - Methods and agents for screening for compounds capable of modulating her2 expression The invention relates to the fields of screening assays and compounds and methods for altering protein expression and levels of protein. In particular, the invention includes assays to screen for agents capable of modulating expression of Her2 and agents capable of modulating Her2 expression. ... 03/29/07 - 20070072185 - Carbohydrate-binding modules of a new family The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member ... 03/29/07 - 20070072184 - Susceptibility gene for alzheimer's disease The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene. ... 03/29/07 - 20070072183 - Topoisomerase hybrids and methods of use The present invention provides hybrid topoisomerases, methods for assaying topoisomerase activity, methods for identifying compounds that modulate topoisomerase activity, and methods for identifying antibacterial agents. ... 03/29/07 - 20070072182 - Methods for amplification of nucleic acid sequences using staggered ligation Methods and kits are provided for producing sense RNA molecules. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 03/29/07 - 20070072181 - Combination therapy for treating alphavirus infection and liver fibrosis The present invention provides methods for treating alphavirus infections; methods of treating hepatitis C virus (HCV) infections; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with ... 03/29/07 - 20070072180 - Mutations in nod2 are associated with fibrostenosing disease in patients with crohn's disease The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of ... 03/29/07 - 20070072179 - Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures The present invention relates to a method and kit for analyzing complex mixtures of biopolymers from one or more samples. ... 03/29/07 - 20070072178 - Novel genetic markers for leukemias The present invention is related to methods for detecting leukemia cells by determining the expression profile of a group of markers. In particular, the type or subtype of leukemia cells in a sample is determined. Further, uses of the group of markers is discloses and compositions comprising these markers. ... 03/22/07 - 20070065876 - Marking The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of ... 03/22/07 - 20070065875 - Ntb-a, a surface molecule involved in natural killer cells activity The present invention relates to a novel protein, termed NTB-A, nucleic acid molecules encoding the same and uses thereof. The invention also relates to methods of regulating Natural Killer cells activity by regulating the activity of NTB-A in vitro, ex vivo or in vivo. The invention also comprises methods of ... 03/22/07 - 20070065874 - Compositions and methods comprising control nucleic acid The present invention relates, in part, to control nucleic acid molecules having no significant sequence homology to any known nucleic acid, and predefined G/C-content. The present invention further relates to method of using control nucleic acid molecules to validate microarray analyses, compositions comprising control nucleic acid molecules, and kits comprising ... 03/22/07 - 20070065873 - Human t2r55 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R55 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065872 - Apparatus and methods for detecting dna in biological samples Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a ... 03/22/07 - 20070065871 - Human t2r71 receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R71 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065870 - Human t2r67 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/22/07 - 20070065869 - Methods for producing ligand arrays Methods for producing ligand arrays, e.g., peptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same are provided. In one embodiment of the subject methods, a substrate having a surface displaying acetate functional groups that produce ... 03/22/07 - 20070065868 - Il-17 receptor like molecules and uses thereof Novel IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 ... 03/22/07 - 20070065867 - Promoter and plasmid system for genetic engineering This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful ... 03/22/07 - 20070065866 - Compositions and methods for suppressing fibrocytes The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, ... 03/22/07 - 20070065865 - Polymorphisms associated with coronary artery disease The invention provides human polymorphisms that are associated with coronary artery disease (CAD). Polymorphisms in genes were identified that confer an increased susceptibility to CAD or a decreased susceptibility. Particular alleles of the polymorphisms were identified as being associated with differential risk. In particular an allele of CDC42 in combination ... 03/22/07 - 20070065864 - Message abundance and allele copy number determination using ivt with single-stranded primer-promoter-selector constructs Disclosed is a single stranded primer-promoter-selector construct comprising (in 3′ to 5′ orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide. ... 03/22/07 - 20070065863 - Method for detecting a risk of cardiovascular disease Single nucleotide polymorphisms associated with serum C-reactive protein levels are disclosed. Also disclosed are methods of using these markers to predict the propensity for cardiovascular diseases and the time to first myocardial infarction. ... 03/22/07 - 20070065862 - Methods for analysis of genetic interactions The present invention provides an isolated interaction polynucleotide that contains a tag sequence and two or more genetic elements. The present invention also provides a method for identifying an interaction between two or more genetic elements. One embodiment of the present invention provides a method for analyzing and identifying the ... 03/22/07 - 20070065861 - Methods for genetic analysis of alternative splicing The present invention provides methods for large-scale functional analysis of splicing variants. Specifically, the present methods provide polynucleotide probes that incorporate exon junction sequences arising from alternative splicing events. In one embodiment of this invention, the function of a splice variant is determined by identifying a polynucleotide comprising an exon ... 03/22/07 - 20070065860 - Accelerated class i and class ii hla dna sequence-based typing There is provided a method for directly typing or sequencing HLA class I or class II alleles from a tissue sample wherein at least one exon of the HLA class I or class II alleles from the sample is amplified in a locus specific manner utilizing two primers, wherein at ... 03/22/07 - 20070065859 - Methods and materials for identifying the origin of a carcinoma of unknown primary origin The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and ... 03/22/07 - 20070065858 - Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an ... 03/22/07 - 20070065857 - Optical system for plant characterization A system is provided to monitor targeted pest populations, disease, presence of transgenic and non-transgenic plants, or targeted pest population in a transgenic crop using remote imagery to discern differences in crops along with pest infestation in all crop varieties. The system relies on the fact that plant leaves are ... 03/22/07 - 20070065856 - Molecular method for diagnosis of prostate cancer Methods for diagnosing or detecting cancerous prostate tissue. A panel of 8 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal prostate tissue and the underexpression of the rest of these marker genes are indicative of cancerous prostate tissue. By ... 03/22/07 - 20070065855 - Biochip and analytical instrument for analyzing same There is provided a biochip capable of quantitatively grasping hybridization efficiency. In the biochip comprising a plurality of probe sites with target molecules bonded thereto, respectively, the probe sites disposed thereon, the marker sites with a known number of fluorescent molecules bonded thereto, respectively, are disposed. With the biochip, the ... 03/22/07 - 20070065854 - Serum-free medium for producing retroviruses A method for obtaining a virus vector free of a serum, and a serum-free medium for cultivation of a virus producer cell which can be used for the method are provided. By cultivating a virus producer cell using a serum-free medium containing serum albumin, it is possible to cultivate the ... 03/22/07 - 20070065853 - Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy The present invention deals with a method of preparing nucleic acids, particularly RNA, from a whole blood sample. The nucleic acids purified by the method of the invention are particularly suited for detection of nucleic acid marker molecules. Preferred are markers for the diagnosis of transmissible spongiform encephalopathy (TSE). Such ... 03/22/07 - 20070065852 - Hiv recombinant vaccine Reagents and methods for making and using HIV recombinant vaccines are disclosed. ... 03/22/07 - 20070065851 - Method for detecting a microorganism in a fecal specimen The invention relates to detecting microorganisms in specimens for the purposes of inter alia diagnoses, screenings, quarantine inspections, and clinical tests. Specifically, it relates to detecting and quantifying enteropathogenic bacteria in a fecal specimen, including Shigella species, Salmonella species, Campylobacter species, enterohemorrhagic E. coli or Verocytotoxin-producing E. coli, Vibrio cholerae, ... 03/22/07 - 20070065850 - Method for diagnosis of heart failure A method for diagnosis of heart failure in a human subject, which comprises the step of: measuring an endoplasmic reticulum (ER)-initiated apoptotic signal such as CHOP in a biological sample originated from the subject is disclosed. According to the invention, by employing the new marker in stead of or in ... 03/22/07 - 20070065849 - Nucleic acid encoding eosinophil eotaxin receptor The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human β-chemokine receptor and has been designated “CC CKR3”. The eosinophil eotaxin receptor may be used to screen and identify compounds that bind to the eosinophil eotaxin receptor. Such compounds would be useful in the treatment ... 03/22/07 - 20070065848 - 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, ... 03/22/07 - 20070065847 - Degeneratively labeled probes The invention is directed to methods for determining whether any of group of analytes of interest are present in a sample, and optionally, in at least one subsequent determination, which of the analytes are present. The invention is also directed towards methods for the rapid and efficient determination of the ... 03/22/07 - 20070065846 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/22/07 - 20070065845 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/22/07 - 20070065844 - Solution-based methods for rna expression profiling The present invention is directed to novel high-throughput, low-cost, and flexible solution-based methods for RNA expression profiling, including expression of microRNAs and mRNAs. ... 03/22/07 - 20070065843 - Polymorphisms in mitochondrial transcription factor a (tfam) gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine ... 03/22/07 - 20070065842 - Detection of survivin in the biological fluids of cancer patients The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing. ... 03/22/07 - 20070065841 - Methods and compositions for the removal of nucleic acid amplification inhibitors An improved method for preparing nucleic acid extracts from environmental samples contaminated by polymerase inhibitors such as humic and fulvic acids is provided. The methods of the invention utilize chemical compositions capable of precipitating humic and/or fulvic acids from organic samples. The methods may be used in connection with the ... 03/22/07 - 20070065840 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single ... 03/22/07 - 20070065839 - Method of identifying agents to prevent or treat diabetes The invention provides an assay for identifying agents that can prevent and treat diabetes. Specifically, the assay is a novel tool for identifying agents that can up regulate cholecystokinin (CCK) expression in pancreatic islets of mammals. The increased expression of CCK triggers an increase in pancreatic β-cell mass and plasma ... 03/22/07 - 20070065838 - Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided. ... 03/22/07 - 20070065837 - Methods and compositions for the detection of chlamydia trachomatis The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid ... 03/22/07 - 20070065836 - Chromosome 1p36 polymorphisms and low bone mineral density The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353. ... 03/22/07 - 20070065835 - Dna fingerprinting using a branch migration assay A method of determining the length of a polynucleotide target is provided. With this method, a target is first hybridized to an array of first probes having different, determined lengths, resulting in the formation of duplexes between the polynucleotide target and the first probes. These duplexes have a single stranded ... 03/22/07 - 20070065834 - Method and sequences for determinate nucleic acid hybridization Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be ... 03/22/07 - 20070065833 - Method of detecting thyroid cancer A method of detecting thyroid cancer in a subject includes obtaining a nucleic acid sample from a bodily sample of the subject and determining whether the nucleic acid sample contains at least one of thyroid stimulating hormone receptor (TSHR) mRNA or thyroglobulin (Tg) mRNA. ... 03/22/07 - 20070065832 - Computer-implemented biological sequence identifier system and method A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search. ... 03/22/07 - 20070065831 - Function and regulation of adamts-1 The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to the function of ADAMTS-1. ... 03/22/07 - 20070065830 - Cloning multiple control sequences into chromosomes or into artificial centromeres Artificially synthesizing 29 homozygous cystic fibrosis core panel controls demonstrates placing multiple homozygous mutant sequences on the same single control DNA sequence to streamline quality control by minimizing extra control assays, time, and costly formatted test materials and testing all controls during every test. Any rare or unavailable reported DNA ... 03/22/07 - 20070065829 - In vitro differentiation of vascular smooth muscle cells, methods and reagents related thereto This invention is directed to an in vitro system for rapidly and uniformly inducing immortalized neural crest cells to differentiate to vascular smooth muscle cells. As excessive proliferation of vascular smooth muscle cells is a phenotypic response to the development of occlusive arteriosclerotic disease, the in vitro system of this ... 03/22/07 - 20070065828 - Oligonucleotide for genotyping of mycoplasma, microarray comprising the oligonucleotide, and method for detection of species using the microarray As described above, the present invention provides a rapid and accurate assay method capable of simultaneously detecting many Mycoplasma and its related strains from a single sample using a microarray comprising novel oligonucleotides for detecting Mycoplasma and its related strains which are known as a source of contamination of cell ... 03/22/07 - 20070065827 - Gene expression profiles and methods of use The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides ... 03/22/07 - 20070065826 - Cationic dye compound for detecting nucleic acid double strand, and detection method and apparatus using same A cationic dye compound having novel uses, the cationic dye compound being capable of conveniently and rapidly detecting a nucleic acid double strand, and a detection method using the cationic dye compound are provided. This invention relates to a cationic dye compound for detecting a nucleic acid double strand, comprising: ... 03/22/07 - 20070065825 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity. ... 03/22/07 - 20070065824 - Method for the detection of cytosine methylations in dna by means of cytidine deaminases The present invention concerns a method for investigating cytosine methylations in DNA sequences. By this means, the DNA to be investigated is reacted with a cytidine deaminase which deaminates cytidine more rapidly than 5-methylcytidine. Cytosine is converted to uracil by the conversion, whereas 5-methylcytosine remains essentially unchanged. The enzymatically pretreated ... 03/22/07 - 20070065823 - Method and compositions for detection and enumeration of genetic variations Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to ... 03/22/07 - 20070065822 - Substrates for spatially selective micron and nanometer scale deposition and combinatorial modification and fabrication A substrate (1) for spatially selective micron and nanometer scale deposition and/or reaction, which has a support (3), a conductive layer (5) on the support, a dielectric layer (7) to hold an electrostatic charge pattern such as a photoconductive layer of a material which dissipates an electric charge upon receiving ... 03/22/07 - 20070065821 - Methods for the prediction of suicidality during treatment This invention provides methods to predict the likelihood of suicidal or self-destructive behavior in a patient during treatment. The method employs the detection of a polymorphism in the SLC6A3 gene at Exon 9 A59G or a surrogate marker, by various methods. Also provided are methods of treatment based on the ... 03/22/07 - 20070065820 - Lipid-associated molecules Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM. ... 03/22/07 - 20070065819 - Novel fprl1 ligands and use thereof By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed. ... 03/22/07 - 20070065818 - Photoprotein with improved bioluminescence Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium. ... 03/22/07 - 20070065817 - Nucleic acid probes for detection of non-viral organisms The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more ... 03/22/07 - 20070065816 - Methods for genotyping Novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample are provided. A reduced complexity sample is generated and then analyzed. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further ... 03/15/07 - 20070059760 - Multi-featured arrays with reflective coating A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously ... 03/15/07 - 20070059759 - Human t2r63 receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R63 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. ... 03/15/07 - 20070059758 - Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF ... 03/15/07 - 20070059757 - Method and compositions for the treating diseases targeting e-cadherin Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro. ... 03/15/07 - 20070059756 - Immunointeractive molecules and their uses in treating subjects suffering from hev b 5 allergies The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having latex allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Hev b 5 allergy. The present invention also extends ... 03/15/07 - 20070059755 - Methods for selective targeting A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound ... 03/15/07 - 20070059754 - Systems and methods for fluorescence detection with a movable detection module A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module ... 03/15/07 - 20070059753 - Detecting gene methylation Methods, kits, and compositions for detecting the methylation status of various genes are useful in various diagnostic applications involving suspected proliferative disorders such as prostate cancer. ... 03/15/07 - 20070059752 - Fluorescence energy transfer probes with stabilized conformations The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties. ... 03/15/07 - 20070059751 - Nucleic acid isolation method In a nucleic acid isolation method for a solid biological sample, since two or more kinds of instruments are used for biological sample disruption and nucleic acid isolation, the operations are complicated, thereby increasing the operating labor, prolonging the operation time, and deteriorating the property of a nucleic acid associated ... 03/15/07 - 20070059750 - Identifier and nucleic acid amplification method of verification using the same There is provided an identification technique that can consistently maintain a set of information specifying a specimen through all the processes from the amplification process to the detection process of a specific sequence. A base sequence incorporating as a set of decodable information an individual code imparted to the specimen ... 03/15/07 - 20070059749 - Nucleic acid, nucleic acid for detecting chlorinated ethylene-decomposing bacteria, probe, method of detecting chlorinated ethylene-decomposing bacteria, and method of decomposing chlorinated ethylene Chlorinated ethylene-decomposition bacteria is detected by performing PCR using nucleic acid comprising 18˜25 nucleotides that preferentially hybridizes to the 16S rRNA or rDNA of chlorinated ethylene-decomposing bacteria and has any of base sequences of SEQ ID No. 1˜15, a base sequence that has at least 90% homology with any of ... 03/15/07 - 20070059748 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers. ... 03/15/07 - 20070059747 - Methods and probe combinations for detecting melanoma The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells. ... 03/15/07 - 20070059746 - Substance carrier using hollow nanoparticle of hepatitis b virus protein and liposome, and method of introducing substance into cell The present invention relates to a method of producing a composite particle of a nanoparticle and a liposome in which a substance to be introduced has been encapsulated, characterized in that a hollow nanoparticle containing a hepatitis B virus protein or a modification thereof is fused to the liposome in ... 03/15/07 - 20070059745 - Blood assessment of injury Methods of injury assessment in an individual include the steps of determining a pattern of expression exhibited by blood cells obtained from an individual and comparing the pattern of expression exhibited by the obtained blood cells to an injury database to assess the injury. ... 03/15/07 - 20070059744 - Corynebacterium glutamicum genes encoding novel proteins Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further ... 03/15/07 - 20070059743 - Method for the design of oligonucleotides for molecular biology techniques The present invention discloses a method that can be used to identify one DNA sequence or one specific group of DNA sequences from a complex biological sample. Diverse molecular biology methods require the use of short DNA sequences, called oligonucleotides, that are artificially synthesized from a description of their composing ... 03/15/07 - 20070059742 - Process of stripping a microarray for reuse Disclosed herein is a process for stripping oligonucleotide target from a microarray to allow reuse of the microarray. The process comprises providing a microarray having probe oligonucleotides attached thereto and target oligonucleotides hybridized to the probe oligonucleotides. The microarray is then incubated with a formulation comprising an organic solvent and ... 03/15/07 - 20070059741 - Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid With an insulated gate field effect transistor in which deoxyribonucleic acid (DNA) probes are immobilized on a gold electrode, extension reaction on the gold electrode is performed with DNA polymerase to directly measure an increased amount of a phosphate group caused by the extension reaction, that is, negative charge, by ... 03/15/07 - 20070059740 - Method of targeting a2b adenosine receptor antagonist therapy Provided herein are methods for determining if a subject will benefit from A2B receptor antagonist therapy. ... 03/15/07 - 20070059739 - Pure mirna sample preparation method The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example, ... 03/15/07 - 20070059738 - Diagnosis and treatment of hepatic disorders The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving α4β7/MAdCAM ... 03/15/07 - 20070059737 - Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon ... 03/15/07 - 20070059736 - Bio-analysis chip, bio-analysis system and bio-analysis method A bio-analysis chip which is convenient in use and can promptly detect microbes with high accuracy. The bio-analysis chip comprises a collection member for collecting microbes in the atmosphere with the microbes adhering to the collection member, and a substrate in the form of a thin plate on which the ... 03/15/07 - 20070059735 - Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample The present invention relates to oligonucleotides useful for determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, capture probes and amplification oligonucleotides, and used in various combinations thereof. ... 03/15/07 - 20070059734 - Reagent for detecting biopolymer and method for detecting biopolymer Detects the presence of binding between a sample biopolymer and a probe biopolymer and the amount of binding, without modifying the sample biopolymer in any way. The present invention provides a reagent for biopolymer detection comprising semiconductor nanoparticles on which a functional group having a positive or negative charge is ... 03/15/07 - 20070059733 - Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups The present methods and apparatus concern nucleic acid sequencing by incorporation of nucleotides into nucleic acid strands. The incorporation of nucleotides is detected by changes in the mass and/or surface stress of the structure. In some embodiments of the invention, the structure comprises one or more nanoscale or microscale cantilevers. ... 03/15/07 - 20070059732 - Detection of target analytes using particles and electrodes The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte ... 03/15/07 - 20070059731 - Ubiquitin mediated fluorescence complementation assay The present invention relates to methods and compositions for identifying covalent joining or modification of proteins. In particular, the present invention relates to covalent fluorescence complementation assays for the detection of modified (e.g., ubiquitinated proteins). The present invention further relates to the use of such fluorescence complementation assays in drug ... 03/15/07 - 20070059730 - Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic ... 03/15/07 - 20070059729 - Nucleic acids and corresponding proteins entitled 282p1g3 useful in treatment and detection of cancer A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or ... 03/15/07 - 20070059728 - Computer-implemented biological sequence identifier system and method A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained ... 03/15/07 - 20070059727 - Directional self-assembly of biological electrical interconnects Microtubules are excellent candidates for the fabrication of nanostructures, including nanowires. A method for controlled nucleation and growth of microtubules on substrates (e.g., gold on a silicon wafer) is provided. The substrate is functionalized with a nucleating agent for microtubule growth. The method can be employed to generate nanoscale structures ... 03/15/07 - 20070059726 - Differential transcript expression Multiple transcripts from the same gene maybe differentially regulated. Finding such differential regulation under distinct physiological conditions implicates the gene in the generation or response to the physiological condition. Transcripts have been identified from five genes which appear to be differentially regulated in lung cancer and normal cells. We have ... 03/15/07 - 20070059725 - Apparatus and method for detecting microscopic organisms using bacteriophage Methods and apparatus are provided for detection of microorganisms in a sample. Methods and apparatus of the invention are based on the specificity that phage, for example bacteriophage, have for target microorganisms, for example bacterium. Typically, phage adsorption to target microorganisms act as signal, or a signal target, for the ... 03/15/07 - 20070059724 - Novel compositions and methods for lymphoma and leukemia The present invention relates to novel sequences for use in diagnosis and treatment of lymphoma and leukemia. In addition, the present invention describes the use of novel compositions for use in screening methods. ... 03/15/07 - 20070059723 - Secreted epithelial colon stromal-1 molecules and uses thereof The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing Secs-1 polypeptides. The invention further provides methods for the treatment, diagnosis, amelioration, or prevention of diseases associated with ... 03/15/07 - 20070059722 - Novel genes and markers associated to type 2 diabetes mellitus Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D using polymorphisms in the T2D risk genes are also disclosed. The genes, gene products and agents of the invention are ... 03/15/07 - 20070059721 - Magi polynucleotides, polypeptides, and antibodies MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays. ... 03/15/07 - 20070059720 - Rna expression profile predicting response to tamoxifen in breast cancer patients The present invention regards predicting a response to a therapy using RNA expression profiling. In particular, a resistance to a chemotherapy, such as tamoxifen, is predicted by comparing expressed genes in a patient on the therapy to a patient sensitive to the chemotherapy. In further embodiments, there is an RNA ... 03/15/07 - 20070059719 - Business methods for prenatal diagnosis The present invention relates to business methods in which screening services and diagnostics for the condition of a fetus are provided. Fetal abnormalities, include chromosomal and other genetic ies, are detected through the analysis of fetal cells obtained from maternal blood samples. ... 03/15/07 - 20070059718 - Systems and methods for enrichment of analytes The present invention relates to methods for detecting and concentrating minute amounts of biohazard analytes, including but not limited to bacteria, protozoa, viral pathogens, and toxins, in environmental and other samples. These analytes can be substantially enriched by the methods of the invention, and further, a second analyte can be ... 03/15/07 - 20070059717 - Systemic lupus erythematosus diagnostic assay The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile ... 03/15/07 - 20070059716 - Methods for detecting fetal abnormality The invention relates to a method of identifying fetal abnormality from a maternal blood sample by capturing an image of a fetal nucleated red blood cell obtained from the maternal blood sample; inputting probe intensities for a plurality of nucleic acid probes that bind fetal nucleic acids of interest; analyzing ... 03/15/07 - 20070059715 - Quantitative gene expression profiling Described herein are approaches to the measurement of gene expression for chosen genes in a biological sample. The methods permit the quantitation of target nucleic acids, e.g., DNAs or RNAs in a nucleic acid sample, both singly and in a multiplex format that permits the determination of levels (e.g., expression ... 03/15/07 - 20070059714 - Detection of presence and antibiotic susceptibility of enterococci The present invention relates in general to the detection of antibiotic resistance genes in Enterococci. The present invention discloses a micro-array for the detection of the presence of bacteria of the genus Enterococcus and antibiotic resistance genes in said organism, a method for the detection of said genes and a ... 03/15/07 - 20070059713 - Ssb-dna polymerase fusion proteins Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR). ... 03/15/07 - 20070059712 - Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein ... 03/15/07 - 20070059711 - Microarray for evaluation of stress-related genes in skin The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 ... 03/15/07 - 20070059710 - Genetic polymorphisms associated with stroke, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, ... 03/15/07 - 20070059709 - Staphylococcus aureus antibacterial target genes This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are ... 03/15/07 - 20070059708 - Gene screen We describe a method for the identification of genes which show regulated expression in response to carbon source utilisation, typically genes associated with the initiation and/or promotion of cell transformation from a non-cancerous to a cancerous phenotype, typically of cells found in the colon; the use of these genes in ... 03/15/07 - 20070059707 - Methods for prenatal diagnosis of chromosomal abnormalities Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus, ... 03/15/07 - 20070059706 - Materials and methods relating to breast cancer classification The inventors set out to identify a set of genes for use as prognostic markers for breast tumours which correlate with the Nottingham Prognostic Index (NPI). Initially they were unable to identify a single set of genes whose expression correlates with the NPI. However after segregating the dataset into molecular ... 03/15/07 - 20070059705 - Fluorescent magnetic nanoparticles and process of preparation This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be ... 03/15/07 - 20070059704 - Detection system The invention provides a methods and materials for detecting an activity of a glycopeptide antibiotic (such as a vancomycin-type antibiotic), in a sample, the method comprising the steps of: (a) providing a microorganism in which a first endogenous gene encoding peptidyltransferase activity is inactivated, which activity is necessary for growth ... 03/15/07 - 20070059703 - Genome mapping of functional dna elements and cellular proteins The disclosure provides methods of examining the binding of proteins to DNA across a genome (e.g., the entire genome or a portion thereof, such as one or more chromosomes or a chromosome regions). In particular, the disclosure relates to a method of identifying a regulatory region (e.g., a protein or ... 03/15/07 - 20070059702 - Disease related protein network The present invention relates to a method for generating a network of direct and indirect interaction partners of a disease-related (poly)peptide comprising the steps of (a) contacting a selection of (poly)peptides suspected to contain one or several of said direct or indirect interaction partners with said disease-related (poly)peptides and optionally ... 03/15/07 - 20070059701 - Fluorescence assays for nucleic acid polymerase activity The present invention provides methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity. ... 03/15/07 - 20070059700 - Methods and compositions for optimizing multiplex pcr primers This invention relates generally to the field of PCR. In particular, the invention provides methods, compositions and kits for optimizing multiplex PCR primers using, inter alia, a plurality of 5′ and 3′ specific primers and a 5′ and a 3′ universal primer at various ratios. ... 03/15/07 - 20070059699 - Methods for detecting toxic and non-toxic cyanobacteria This invention is related to a method for detecting toxic and non-toxic cyanobacteria. The method comprises that nucleic acid from a biological sample is brought into contact with an oligonucleotide designed to be specific for the mcy gene, in particular mcyE and/or mcyD, and with an oligonucleotide designed to be ... 03/15/07 - 20070059698 - Marks as modifers of the pten pathway and methods of use Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that ... 03/15/07 - 20070059697 - Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, ... 03/15/07 - 20070059696 - Assessment method The present invention relates generally to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response in a mammal. More particularly, the present invention relates to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response by analysing one or ... 03/15/07 - 20070059695 - Sgk1 as diagnostic and therapeutic target The invention relates to the utilization of a substance for diagnostic determination of sgk1 (serum and glucocorticoid dependent kinase 1) and to the utilization of an active agent in order to influence sgk1 for therapeutic treatment of diseases associated with disordered activity of the tissue factor and to a diagnostic ... 03/15/07 - 20070059694 - Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep1 (prostaglandin e2 ep1) The invention provides a human prostaglandin E2 EP1 which is associated with the cardiovascular diseases, respiratory diseases, hematological diseases, urological diseases, gastrointestinal diseases, endocrinological diseases and metabolic diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, hematological ... 03/15/07 - 20070059693 - Hybridization-based biosensor containing hairpin probes and use thereof A sensor chip that includes: a fluorescence quenching surface; a nucleic acid probe that contains first and second ends with the first end bound to the fluorescence quenching surface, a first region, and a second region complementary to the first region, the nucleic acid probe having, under appropriate conditions, either ... 03/15/07 - 20070059692 - Array oligomer synthesis and use The present disclosure provides efficient and reproducible methods for individually synthesizing oligomers in a parallel manner (e.g., oligonucleotides) on a solid support to produce pools of oligomers. Pools of oligonucleotides can be used for a variety of genomic and proteomic applications, including synthesis of genes or long DNA of any ... 03/15/07 - 20070059691 - Method for determining the susceptibility of a subject to infection A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii) optionally comparing the level of LL-37 in said sample to a control sample; and (iv) determining the susceptibility of said ... 03/15/07 - 20070059690 - met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands Disclosure of a method for the detection and quantitation of polynucleotide sequences in a sample of biological or non-biological material through target poly nucleotide sequence amplification by polymerase chain reaction using chemically labeled oligonucleotide amplification primers and formation of an entity between the amplified polynucleotide sequence and chemically labeled polynucleotide ... 03/15/07 - 20070059689 - Hybrid glycosylated products and their production and use Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also produces or is supplied with an aglycone template. At least some of the components ... 03/15/07 - 20070059688 - Gastrointestinal chemosensory receptors This invention provides isolated nucleic acid and amino acid sequences of gastrointestinal endocrine cell specific G-protein coupled receptors, methods of detecting such receptors, and methods of screening for ligands of such receptors. Furthermore, this invention demonstrates that SrC-1 enteroendocrine cells express multiple bitter taste receptors as well as a-subunits of ... 03/15/07 - 20070059687 - Process for evaluating phagocytotic function and use thereof A digested phagocyte prepared by contacting in vitro a phagocyte with a foreign microorganism and isolating the phagocyte so contacted; a process for producing the same; and a process and a kit in which these are utilized are disclosed. An experimental model, which enables in vitro evaluation of a phagocytotic ... 03/08/07 - 20070054314 - Adiponectin receptor and gene encoding the same The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is ... 03/08/07 - 20070054313 - Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided. ... 03/08/07 - 20070054312 - Human transmembrane proteins The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN. ... 03/08/07 - 20070054311 - Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library ... 03/08/07 - 20070054310 - Novel polypeptide, cdna encoding the same, and use thereof Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or ... 03/08/07 - 20070054309 - Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific ... 03/08/07 - 20070054308 - Fluorescence polarization assay The present invention relates to methods for detecting the presence of one or more analytes of interest in a sample by measuring changes in fluorescence anisotropy as a result of binding of the analytes to specific aptamers. The aptamers are immobilized on a solid support and may be in the ... 03/08/07 - 20070054307 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of ... 03/08/07 - 20070054306 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/08/07 - 20070054305 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/08/07 - 20070054304 - Compositions and methods for detection and isolation of phosphorylated molecules The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and ... 03/08/07 - 20070054303 - Expression vectors and methods Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage. ... 03/08/07 - 20070054302 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of ... 03/08/07 - 20070054301 - Methods, compositions and kits for isothermal amplification of nucleic acids Methods and compositions are described for isothermal nucleic acid amplification of a nucleic acid template strand by using an oligonucleotide primer that includes an AT-rich nucleotide sequence and a polymerase having strand displacement activity. ... 03/08/07 - 20070054300 - Method for the identification and quantification of microorganisms useful in biomining processes The method comprises performing a two-stage PCR known as nested PCR, where in the first stage, called primary PCR, 16S ribosomal DNA sequences (nucleotides 27 to 1492, with E. coli rDNA numbering) are amplified using universal primers for the Bacteria and Archaea kingdoms. In the second stage, these primary amplicons ... 03/08/07 - 20070054299 - Apparatus for active programmable matrix devices A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. Preferably, a fluidic system flow a sample across an active area of the biochip, increasing diagnostic efficiency. Preferably, the fluidic system includes ... 03/08/07 - 20070054298 - Methods for enzyme-mediated coupling of oligomers The present invention is directed to a method for synthesizing sequence specific short and long chain length heteropolymers. More specifically, the method is directed to enzyme-mediated ligation of telechelic sequence specific oligomers to generate abiotic linked oligomers and concatenated synthetic oligomers. The invention also encompasses abiotic linked oligomers and abiotic ... 03/08/07 - 20070054297 - Mammalian relaxin receptors High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are orphan leucine-repeat-containing, G protein-coupled receptors. These receptors have a wide and a unique tissue expression pattern. The receptors, particularly soluble fragments thereof, are useful ... 03/08/07 - 20070054296 - Methods for multiplexing recombinase polymerase amplification This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. ... 03/08/07 - 20070054295 - Gc tag-modified bisulfite genomic dna sequencing for continuous methylation spectra The present invention relates to a tag-modified bisulfite genomic sequencing (tBGS) method developed for simplified evaluation of DNA methylation sites. The method employs direct cycle sequencing of PCR products at kilobase scale, without conventional DNA fragment cloning. The method entails subjecting bisulfite-modified genomic DNA to a second-round PCR amplification employing ... 03/08/07 - 20070054294 - Cotton event pv-ghgt07(1445) and compositions and methods for detection thereof The present invention provides DNA compositions and assays for detecting the presence of the DNA compositions in PV-GHGT07(1445) cotton event based on the DNA sequence of the recombinant construct inserted into the cotton genome and of the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the ... 03/08/07 - 20070054293 - Microfluidic chaotic mixing systems and methods Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump ... 03/08/07 - 20070054292 - Bacteriophage linked immunosorbent assay for rapid, sensitive detection of multiple analytes The invention is a method for the development of a platform that enables the efficient and simultaneous creation of multiple detection assays. The invention entails the use of any bacteriophage, modified to carry a reporter gene, to which any analyte-recognizing moiety is attached via the capsid. The modified bacteriophage is ... 03/08/07 - 20070054291 - System for detection of nucleic acids System, including methods, apparatus, and kits, for detection of nucleic acids. ... 03/08/07 - 20070054290 - Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of ... 03/08/07 - 20070054289 - Identification of genes involved in fertility, ovarian function and/or fetal/newborn viability A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, ... 03/08/07 - 20070054288 - Programmable molecular barcodes The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind ... 03/08/07 - 20070054287 - Method for identifying medically important cell populations using micro rna as tissue specific biomarkers The present teachings provide methods for diagnosing biological conditions, including cancer. In some embodiments, a test sample is collected from a subject such as a clinical patient, wherein the test sample comprises background tissue and may or may not contain cells from a tissue of interest. Observation of a target ... 03/08/07 - 20070054286 - Arrays of nucleic acid probes for analyzing biotransformation genes The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three ... 03/08/07 - 20070054285 - Method for isolating nucleic acids Described herein is a method in which genomic nucleic acid of a cell can be separated from nucleic acid having a molecular weight that is lower than the molecular weight of the genomic nucleic acid (e.g., plasmid DNA) of the cell directly from a cell growth culture. Also described herein, ... 03/08/07 - 20070054284 - Nucleic acid and corresponding protein entitled 184p1e2 useful in treatment and detection of cancer A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene ... 03/08/07 - 20070054283 - Dna sequencing method using step by step reaction The present invention provides an inexpensive DNA sequencing method with high-sensitivity. The method of the present invention comprising the steps of, adding an given amount of dATP for step by step complementary strand synthesis and subtracting the background luminescence intensity caused by dATP from the measured luminescence intensity to obtain ... 03/08/07 - 20070054282 - Method for the detection of gene transcripts in blood and uses thereof The present invention relates generally to the identification of biomarkers of conditions including disease and non disease conditions as well as identifying compositions of biomarkers. The invention further provides a method of diagnosing disease, monitoring disease progression, and differentially diagnosing disease. The invention further provides for kits useful in diagnosing, ... 03/08/07 - 20070054281 - Compositions and methods relating to osteoarthritis Described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having osteoarthritis. Also described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having a particular stage of ... 03/08/07 - 20070054280 - High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics An optical micro-array reader system includes microchip, VCSEL, microlens and detector arrays. The microchip array includes multiple sample spots to be separately analyzed. The VCSEL array is disposed to simultaneously illuminate more than one of the multiple spots. The microlens array focuses fluorescences or other optical emissions from the sample ... 03/08/07 - 20070054279 - Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one ... 03/08/07 - 20070054278 - Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof The present invention is based on the discovery of polymorphisms in enzyme genes and encoded enzyme protein variants. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and ... 03/08/07 - 20070054277 - Computer-directed assembly of a polynucleotide encoding a target polypeptide The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding ... 03/08/07 - 20070054276 - Polynucleotide analysis and methods of using nanopores Polynucleotide analysis systems and methods of nanopore analysis are provided. ... 03/08/07 - 20070054275 - Method evolved for recognition of thrombophilia (mert) Methods for predicting an individual's genetic risk for developing venous thrombosis in diverse ethnic populations is disclosed, as are arrays and kits which can be used to practice the method. The method includes screening for mutations, polymorphisms, or both, in at least eight venous thrombosis-related molecules, such as antithrombin III, ... 03/08/07 - 20070054274 - Gene modulation by rb2/p130 expression The present invention discloses a set of molecular signatures modulated by RB2/p130 for lung cancer cells and a method of determining whether to use a RB2/p130 gene expression system or a protein encoded by the system to modulate a gene or gene expression pattern in lung cancer cells of mammals. ... 03/08/07 - 20070054273 - Microarray devices having controllable reaction volume This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction, ... 03/08/07 - 20070054272 - Method of preparing dna fragments by selective fragmentation of nucleic acids and applications thereof The invention relates to a method of preparing DNA fragments by selective fragmentation of nucleic acid fragments. The inventive method comprises a first selection step involving selection of short fragments, consisting in: a) preparing first double-stranded DNA fragments F1 using at least one restriction enzyme E1 which can randomly fragment ... 03/08/07 - 20070054271 - Gene expression in breast cancer The invention features nucleic acids encoding proteins that are expressed at a higher or a lower level in breast cancer cells than in normal breast cells or in a cell of one grade or stage of breast cancer than in a cell of another grade or stage of breast cancer. ... 03/08/07 - 20070054270 - Preloaded microfluidic devices A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a ... 03/08/07 - 20070054269 - Molecular cardiotoxicology modeling The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of ... 03/08/07 - 20070054268 - Methods of diagnosis and prognosis of ovarian cancer The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expression of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific scanner sub-type. The ovarian cancer-associated genes and ... 03/08/07 - 20070054267 - Primer and probe for detecting vibrio vulnificus and detection method using the same To produce a high-performance specific gene amplification primer for detecting, quantifying, or identifying Vibrio vulnificus, having low risk of misidentification and practically sufficient amplification efficiency and amplification specificity. We have determined partial nucleotide sequences of gyrB, rpoD, and recA genes of Vibrio vulnificus and the closely related species, revealed their ... 03/08/07 - 20070054266 - Chemical sensor system A chemical sensor utilizing a chemical receptor (for example, one stimulating the sense of taste or smell) is provided. More specifically speaking, such a receptor is introduced into cells and the cells are immobilized on a support to form a chip. This chip is then employed as a component of ... 03/01/07 - 20070048784 - Novel human hydrolase family members and uses thereof The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and ... 03/01/07 - 20070048783 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 03/01/07 - 20070048782 - Methods for assessing and treating leukemia Methods for treating leukemia patients include analyzing gene expression profiles of a patient to determine whether the patient is likely to respond to treatment with farnesyl transferase inhibitor (FTI) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes ... 03/01/07 - 20070048781 - Mammalian cytokines; related reagents and methods Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. ... 03/01/07 - 20070048780 - Circovirus sequences associated with piglet weight loss disease (pwd) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a ... 03/01/07 - 20070048779 - Method for detecting target plant genus The method for detecting species in a target plant genus, particularly an allergenic plant genus such as the genus Fagopyrum, can make it possible to detect with high sensitivity, for example, about 1 ppm of the plant(s) in cases where the plant(s) is contained in a food ingredient or food ... 03/01/07 - 20070048778 - Uses of human zven antagonists The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine. ... 03/01/07 - 20070048777 - Method of nucleic acid analysis by optical detection using disk There is provided a method or structure of carrying out optical measurement for the change of the state of the reactive sample solution at two or more measurement points of the channel simultaneously and continuously in a flow system reaction in which the reactive proceeds according to the elapsed time ... 03/01/07 - 20070048776 - Translation enhancer-element dependent vector systems A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods ... 03/01/07 - 20070048775 - Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites. ... 03/01/07 - 20070048774 - Continuous in-vitro evolution Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby ... 03/01/07 - 20070048773 - Detection of polyphosphate using fluorescently labeled polyphosphate acceptor substrates Provided herein are methods and compositions for fluorogenic detection of a polyphosphate released from a nucleoside polyphosphate by the enzymatic action of a nucleic acid polymerase. The methods and compositions are based on the transfer of a free polyphosphate (or polyphosphate labeled with a fluorescence dye) to a polyphosphate acceptor ... 03/01/07 - 20070048772 - Mammalian iap gene family, primers, probes and detection methods Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. ... 03/01/07 - 20070048771 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the ... 03/01/07 - 20070048770 - Reagents and methods for processing biological samples Methods and processing reagents for improving washing and aging a biological sample in an assay are disclosed. The processing reagents comprise an aqueous base reagent and a low vapor pressure composition in sufficient amount to raise the boiling point of the base reagent. The methods comprise applying the base reagent ... 03/01/07 - 20070048769 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to ... 03/01/07 - 20070048768 - Methods for screening for gene specific hybridization polymorphisms (gshps) and their use in genetic mapping and marker development A method for identification of gene specific hybridization polymorphisms (GSHPs) and their use is presented. The method involves the steps of a) global screening for hybridization polymorphisms using microarray; b) enzyme mediated genome complexity reduction; c) enzyme mediated differential signal amplification and noise reduction; d) data extraction and GSHP identification; ... 03/01/07 - 20070048767 - Marker for a psychosis or a mood disorder An association of a genetic marker with psychosis, a mood disorder, or a combination thereof is provided. Polymorphisms in the GRIN2B gene or alteration in the levels of GRIN2B gene products can be used to diagnose or identify a susceptibility to psychosis, a mood disorder, or a combination thereof. In ... 03/01/07 - 20070048765 - Use of genetic information for identity authentication This invention incorporates genetic information about an individual for use in verifying said individual's identity in transactions where improper identity, identity theft or other use of false identifying information creates financial, personal or other risks. The invention utilizes secure methods wherein an individual's genetic identity is stored by an authenticating ... 03/01/07 - 20070048764 - Indicator polynucleotide controls Methods of selecting indicator polynucleotide controls for use, for example, in determining amounts of indicated polynucleotides in a sample are described. Devices that include indicator polynucleotide controls and data representations relevant to them are also described. A storage medium comprising data obtained from a study using a nucleotide array that ... 03/01/07 - 20070048763 - Polymorphism in the macrophage migration inhibitory factor (mif) gene as marker for prostate cancer The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence ... 03/01/07 - 20070048762 - Real-time monitoring of nucleic acid target-identifying signals This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other ... 03/01/07 - 20070048761 - System and method for authenticating multiple components associated with a particular product A method for authenticating a product where the product is composed of a plurality of components is described. The method for authenticating the product comprises providing a liquid compound, e.g. paint, that comprises at least one invisible market, e.g. nucleic acid, in which the compound is associated with a first ... 03/01/07 - 20070048760 - Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated ... 03/01/07 - 20070048759 - Detection of target molecules with labeled nucleic acid detection molecules The invention is directed to a detection molecule for detection of a target molecule. The detection molecule includes a probe specific to the target molecule. One or more multimer nucleic acid molecules are connected to the probe, whereby the multimer is also coupled to at least one detectable label. The ... 03/01/07 - 20070048758 - Improved primer-based amplification methods The present invention provides methods for amplifying a target nucleic acid with greater efficiency and accuracy by using one or more flap primers. ... 03/01/07 - 20070048757 - Methods for characterizing cells using amplified micro rnas The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. In some embodiments, the present teachings provide methods of forming micro RNA signatures from single cells, including stem cells. In some embodiments, the present teachings provide methods for determining the ... 03/01/07 - 20070048756 - Methods for whole genome association studies Methods for determining the genotype of more than 400,000 Single Nucleotide Polymorphisms (SNPs) in samples of genomic DNA are provided. A collection of SNPs that may be interrogated by the methods is disclosed in SEQ ID NO: 1-1,074,930. Each sequence is the sequence of a human SNP allele and the ... 03/01/07 - 20070048755 - Assay for determining the sex of primates The present invention relates to methods for identifying the sex of a primate by providing a biological sample collected from the primate and contacting the biological sample with one or more probes that hybridize to a target SRY nucleic acid molecule at a particular location within a consensus SRY nucleotide ... 03/01/07 - 20070048754 - Epidermal growth factor receptor mutations Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“Pl3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant Pl3K, and/or mutant B-Raf ... 03/01/07 - 20070048753 - Sodium channel protein type iii alpha-subunit splice variant The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same. ... 03/01/07 - 20070048752 - Mass tags for quantitative analyses This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes. ... 03/01/07 - 20070048751 - Method of diagnosing type ii diabetes mellitus using multilocus marker, polynucleotide including marker associated with type ii diabetes mellitus, and microarray and diagnostic kit including the polynucleotide Provided are a polynucleotide including a marker associated with type II diabetes mellitus and a method of diagnosing type II diabetes mellitus in an individual, which includes determining a nucleotide of a polymorphic site of at least one polynucleotide of Table 1 in the specification. ... 03/01/07 - 20070048750 - Rapid efficacy assessment method for lung cancer therapy The present invention discloses a method for rapid assessment of lung cancer therapy efficacy in a few days instead of weeks by conventional imaging methods. This method can also be used to detect relapse of the cancer and to improve the current TNM cancer staging method for more accurate prognosis. ... 03/01/07 - 20070048749 - Method for survival prediction in gastric cancer patients after surgical operation using gene expression profiles and application thereof Disclosed is a method for survival prediction in gastric cancer patents after surgical operation, which uses a survival prediction model determined by known statistical method and gene expression microarray profiles. The survival prediction model is established by selecting special genes expressing significantly differential from pairs of cancerous and noncancerous tissue ... 03/01/07 - 20070048748 - Mutant polymerases for sequencing and genotyping The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods. ... 03/01/07 - 20070048747 - Methods for assaying analytes Described herein are methods for assaying analytes. ... 03/01/07 - 20070048746 - Multiplex data collection and analysis in bioanalyte detection Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and ... 03/01/07 - 20070048745 - Systems and methods for partitioned nanopore analysis of polymers Devices, systems, and methods for nanopore analysis of polymers are provided. One exemplary device, among others, includes a substrate having a plurality of partitioned nanopores configured to receive a polymer sample. In addition, the device includes a plurality of sets of resonant tunneling electrodes adjacent the partitioned nanopore. At least ... 03/01/07 - 20070048744 - Single molecule sequencing of captured nucleic acids The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques. ... 03/01/07 - 20070048743 - Methods and compositions for assessing candidate acgh probe nucleic acids Methods for evaluating surface-bound polynucleotides, e.g., candidate aCGH probe nucleic acids, are provided. Specifically, the methods involve contacting an array of surface-bound polynucleotides with a validation nucleic acid composition and assessing binding of the surface-bound polynucleotides. The methods may be used to screen for surface bound polynucleotides that have desirable ... 03/01/07 - 20070048742 - Detection method for chromosome abnormality and microarray chip The present invention relates to a method of detecting a chromosome abnormality and a microarray chip for detecting a chromosome abnormality. More specifically, the present invention is directed to a method of detection for chromosome abnormality in order to easily diagnosing the health condition and disease of the subject by ... 03/01/07 - 20070048741 - Methods and kits for sense rna synthesis Methods and kits are provided for performing sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... 03/01/07 - 20070048740 - Full-length cdna Novel full-length cDNAs are provided. 1,995 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information ... 03/01/07 - 20070048739 - Method for identifying biological species The present invention provides a method for identifying species and subspecies in a biological sample through the selective amplification of segments of nucleic acid that code a target region of the cytoplasmatic beta-actin protein, which is present in all the organisms concerned. The method comprises DNA extraction from the sample; ... 03/01/07 - 20070048738 - Methods and compositions for diagnosis, staging and prognosis of prostate cancer The present invention provides, inter alia, novel methods and compositions for the diagnosis, staging and prognosis of prostate cancer, based on DNA methylation and/or modulation of gene expression, including transcriptional silencing. Preferred diagnostic and/or prognostic nucleic acid and protein markers include at least one of: the differentially (relative to benign ... 03/01/07 - 20070048737 - Calcium phosphate ceramics and particles for in vivo and in vitro transfection The invention relates to a method of modifying the surface of calcium phosphate ceramics and powders. The inventive method involves maturation in a culture medium, thereby causing epitaxial carbonated apatite growth at the surface of the aforementioned ceramics and powders. The invention also relates to the use of said modified ... 02/22/07 - 20070042422 - Oligonucleotides for rapidly identifying microbial dna or rna An oligonucoeotide selected from the group consisting of ISN2 (SEQ ID NO: 43), ISN2* (SEQ ID NO: 44), ISN (SEQ ID NO: 34), ISP2 (SEQ ID NO: 46), ISP2* (SEQ ID NO: 45) and ISP (SEQ ID NO: 33). ... 02/22/07 - 20070042421 - Method of identifying nucleic acids Disclosed are methods for identifying nucleic acids in a sample of nucleic acids in which nucleic acids are initially present in unequal amounts. The methods include partitioning the starting population of nucleic acids to form one or more subpopulations, and then identifying nucleic acids that are present in different amounts ... 02/22/07 - 20070042420 - Liver tumor marker sequences Polypeptides whose expression is upregulated in liver tumor cells and cells from liver preneoplastic foci relative to expression in normal liver cells are disclosed as are polynucleotides that encode the polypeptides. In humans, the polynucleotide maps to a region of chromosome 15. The overexpression has also been confirmed in human ... 02/22/07 - 20070042419 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the ... 02/22/07 - 20070042418 - Therapeutic modulation of the fas pathway A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. ... 02/22/07 - 20070042417 - Methods of using zven polynucleotides The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The ... 02/22/07 - 20070042416 - Dendritic enriched secreted lymphocyte activation molecule The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and ... 02/22/07 - 20070042415 - Anti-fused antibodies The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused. ... 02/22/07 - 20070042414 - Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical ... 02/22/07 - 20070042413 - Platelet-derived growth factor d, dna coding therefor, and uses thereof PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in ... 02/22/07 - 20070042412 - Detection of biologically active compounds A probe comprises a supramolecular structure having a chemical or biological recognition moiety; a phosphorescent reporter label; and an effector which interacts with the label so that the probe alters its phosphorescent characteristics on recognition of a target. The phosphorescent reporter label may have an emission lifetime in the order ... 02/22/07 - 20070042411 - Multiplexed pcr assay for detection of bovine spongiform encephalopathy (bse)-associated bovine prion protein gene (prnp) polymorphisms A multiplexed PCR assay system and method are provided for detection of bovine prion protein gene (PRNP) insertion/deletion polymorphisms that are associated with bovine spongiform encephalopathy (BSE), thereby identifying a population of cattle or individual therefrom that possesses an elevated level of putative resistance or susceptibility to BSE. Such system ... 02/22/07 - 20070042410 - Screening method for genes of brewing yeast Provided herein are a method for selecting a gene participating in the desired brewing character and compiling a database of the whole genome sequence of industrial yeast; identifying a gene participating in a brewing characteristic from the database; functional analysis of the gene; and a DNA array of the whole ... 02/22/07 - 20070042409 - Mammalian obestatin receptors A high affinity obestatin receptor is provided; the orphan receptor GPR39. The receptor mediates obestatin activities. The obestatin receptor (GPR39) and fragments thereof, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of obestatin. In addition to use as a therapeutic agent, GPR39 polypeptides are ... 02/22/07 - 20070042408 - Nucleotide sequence for assessing transmissible spongiform encephalopathies The present invention is directed to the assessment of transmissible spongiform encephalopathy (TSE) using a sample from a living individual. The assessment is based on the use of an RNA marker molecule in a sample of whole blood. The RNA encodes a hypothetical cystein protease. The invention is further directed ... 02/22/07 - 20070042407 - Modified nucleosides and nucleotides and uses thereof The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing nucleosides and nucleotides which exhibit enhanced fluorophore intensity by virtue of reduced quenching effects. ... 02/22/07 - 20070042406 - Diffusion mediated clean-up of a target carrier fluid Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier ... 02/22/07 - 20070042405 - Enhanced diagnostic multimarker serological profiling The present invention is related to methods of early diagnosis of ovarian cancer in a patient by determining serum levels of blood markers using a novel LabMAP™ technology (Luminex Corp., Austin, Tex.), which allows for simultaneous measurement of the blood markers in serum. The panel of blood markers offers extremely ... 02/22/07 - 20070042404 - Compositions and method for detecting endonuclease activity The present invention relates to compositions and a cell-based assay for detecting endonuclease activity. The assay involves the basic principle of linking a endonuclease cleavage event with cell survival. When an endonuclease cleaves its cognate endonuclease recognition site located on a vector containing a toxic reporter protein, the vector is ... 02/22/07 - 20070042403 - Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions ... 02/22/07 - 20070042402 - Method for predicting human longevity The present disclosure concerns methods of detecting levels of one or more molecules(s), longevity predicting marker(s), in a sample, and using these levels of the marker(s) to predict a condition. In a particular embodiment, the present invention concerns methods of detecting longevity predicting marker(s), in a sample, preferably to assess ... 02/22/07 - 20070042401 - Methods for synthesis of encoded libraries The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. ... 02/22/07 - 20070042400 - Methods of preparing nucleic acid for detection Methods of preparing nucleic acid from polysaccharide-containing samples for detection by providing one or more glycosidases to the sample to degrade polysaccharides are provided. The nucleic acids can further be extracted from the sample. The method is particularly useful for detecting nucleic acid in samples with high starch content. ... 02/22/07 - 20070042399 - Biological materials and uses thereof The invention relates to a library, methods of making a library of biologically active molecules and uses thereof. The library comprises a plurality of chelating ligand pairs, each said ligand pair including two ligands that bind specifically to distinct epitopes on the same target molecule and the two ligands of ... 02/22/07 - 20070042398 - Cyanine dyes and methods of use The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological ... 02/22/07 - 20070042397 - Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding ... 02/22/07 - 20070042396 - Nucleic acid purification apparatus including photovoltaic device, microfluidic apparatus including the nucleic acid purification apparatus, and method of purifying nucleic acid using the nucleic acid purification apparatus Provided are a nucleic acid purification apparatus including a chamber that includes an inlet and an outlet, at least two electrodes that defines the chamber and form an electric field, a photovoltaic device that applies a bias to the electrodes, a microfluidic apparatus including the same, and a method of ... 02/22/07 - 20070042395 - Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide ... 02/22/07 - 20070042394 - Apparatus for producing a dna doped carbon cluster and method for producing the same The object of the present invention is to provide an apparatus for producing a DNA doped carbon cluster capable of introducing DNA into the cavity of a carbon cluster. An apparatus for producing a DNA doped carbon cluster comprising a radio frequency current applying electrode which is composed of a ... 02/22/07 - 20070042393 - Discrimination method of target base in dna, and allele specific primer used in the method of the same An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one ... 02/22/07 - 20070042392 - Novel nucleic acids and polypeptides The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof. ... 02/22/07 - 20070042391 - Nucleic acid and amino acid sequences relating to staphylococcus epidermidis for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting ... 02/22/07 - 20070042390 - Method and device for critical dimension detection by molecular binding Critical Dimension (CD) of features on a semiconductor substrate may be indicated utilizing the site-specific binding properties of organic or biological molecules. In accordance with one embodiment of the present invention, a fluorescent tagged organic molecule is fabricated having a length corresponding to the desired CD. The semiconductor substrate is ... 02/22/07 - 20070042389 - Method and sequences for determinate nucleic acid hybridization Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be ... 02/22/07 - 20070042388 - Method of probe design and/or of nucleic acids detection It is provided a method of designing oligonucleotide probe(s) for nucleic acid detection comprising the following steps in any order: (i) identifying and selecting region(s) of a target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE; and (ii) designing oligonucleotide ... 02/22/07 - 20070042387 - Promoter, promoter control elements, and combinations, and uses thereof The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels. ... 02/22/07 - 20070042386 - Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system The present invention contemplates monitoring the amplification of nucleic acid using chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one ... 02/22/07 - 20070042385 - Novel compositions and methods in cancer The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention ... 02/22/07 - 20070042384 - Method for isolating and modifying dna from blood and body fluids This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses. ... 02/22/07 - 20070042383 - Mycobacterial diagnostics The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for ... 02/22/07 - 20070042382 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods ... 02/22/07 - 20070042381 - Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known ... 02/22/07 - 20070042380 - Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof The present invention relates to a first group of novel oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known “target” genes, many of which are known ... 02/22/07 - 20070042379 - Modified dna cleavage enzymes and methods for use (as amended by isa) Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme ... 02/22/07 - 20070042378 - Regulation of prokaryotic gene expression with zinc finger proteins Chimeric zinc finger proteins, and methods of using zinc finger proteins for regulating gene expression in prokaryotes are disclosed herein. ... 02/22/07 - 20070042377 - Biosensor A sensor for determining the presence of an analyte in a test sample, said sensor comprising a nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIII3 or VIIII3 of the Periodic Table, ... 02/22/07 - 20070042376 - Mn/ca ix and cancer prognosis Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic/neoplastic diseases subject to the prognostic methods of this ... 02/22/07 - 20070042375 - Isolated berovin photoprotein and use thereof The invention relates to the photoprotein berovin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein berovin. ... 02/22/07 - 20070042374 - Novel protein The present invention provides a protein containing the same or substantially the same amino acid sequence as the amino acid sequence starting at Amino Acid No. 1 in the amino acid sequence shown by SEQ ID NO:2 or 4, the nucleic acid that encodes it, a method of screening a ... 02/22/07 - 20070042373 - Protein identification methods and systems The present invention relates to methods and systems for identifying proteins. In particular the invention provides a method for identifying a protein through amino acid sequences of one or more query peptides generated from the protein. The method involves translating amino acid sequences of the query peptides to all possible ... 02/22/07 - 20070042372 - Method for designing dna codes used as information carrier The present invention provides a method for designing DNA code consisting of a set of information codes as an information carrier to write optional information into an optional noncoding region not including any DNA genetic information which can avoid an error occurring when the designed DNA is used. A set ... 02/22/07 - 20070042371 - Mptens as modifers of the pten/igf pathway and methods of use Human MPTEN genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of PTEN/IGF, comprising screening for agents that modulate the activity of MPTEN are provided. ... 02/22/07 - 20070042370 - Fluorescent substrates for detecting organophosphatase enzyme activity Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and ... 02/22/07 - 20070042369 - Methods of selection, reporting and analysis of genetic markers using borad-based genetic profiling applications Disclosed are a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals ... 02/22/07 - 20070042368 - Detection and monitoring of lung cancer Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used, ... 02/22/07 - 20070042367 - Lab-on-chip system for analying nucleic acid This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and ... 02/22/07 - 20070042366 - Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same Featured are devices and systems embodying one or more solid-state nanopores useable for sensing and/or characterizing single macromolecules as well as sequencing DNA or RNA and/or determining RNA secondary structures. In once solid state nanopore of the present invention the width and/or length of the nanopore is defined or established ... 02/22/07 - 20070042365 - Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid A method for detecting the presence of a target nucleic acid in a sample including treating a sample containing nucleic acid with an agent that modifies unmethylated cytosine; providing to the treated sample a detector ligand in the form of an intercalating nucleic acid (INA) capable of binding to a ... 02/22/07 - 20070042364 - Target genes for inflammatory bowel disease Two genes have been discovered that show single nucleotide polymorphisms that are differentially expressed in patients with inflammatory bowel disease (IBD) as compared to unaffected controls. These two genes, FLJ21425 and CSF1R (colony stimulating factor 1 receptor), are located close together on chromosome 5q33 which was known to have other ... 02/22/07 - 20070042363 - Novel polypeptide and nucleic acid encoding the same A novel protein which binds with tumor necrosis factor receptor associated factor 2, TRAF2, as well as a nucleic acid coding for the protein is disclosed. From a mouse cDNA library, a cDNA coding for a novel protein which binds with TRAF2 was discovered by mammalian two-hybrid assay, the cDNA ... 02/22/07 - 20070042362 - Methods and apparatus for use in genetics classification including classification tree analysis Methods and apparatus for use in genetic trait classification involving at least two genes associated with a genetic trait are described. In one illustrative method, a value for use in classifying an individual into one of a plurality of trait classes associated with the genetic trait is calculated. The value ... 02/22/07 - 20070042361 - Human secreted proteins The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and ... 02/22/07 - 20070042360 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers. ... 02/15/07 - 20070037205 - Methods and apparatus for cell based screening Methods, kits and systems for identifying at least one compound, from a set of compounds, that modulates the growth or biological activity of a cell. Also high-throughput, tumor cell-based screening assay methods for identifying one or more cell-growth modulating compounds from among a library of compounds. ... 02/15/07 - 20070037204 - Gene overexpressed in cancer Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide ... 02/15/07 - 20070037203 - Novel 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, ... 02/15/07 - 20070037202 - Potentiation of cancer therapies by znf217 inhibition This invention provides methods, reagents and kits for treating cancer in a patient or subject, e.g., a human. Accordingly, the present methods can be used to monitor the efficacy of a cancer treatment and to treat cancer, e.g., by inhibiting the expression and/or activity of ZNF217 in a neoplastic cell. ... 02/15/07 - 20070037201 - Hybrid model for dna probe design and validation using nonlinear and linear regression methods Methods and systems for selecting oligonucleotide probes for use in microarray applications are provided herein. The described methods use a combination of measured probe performance and predicted probe performance to select probes. Nucleic acid arrays containing probes selected by the described methods are described. Also included are algorithms for performing ... 02/15/07 - 20070037200 - Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's ... 02/15/07 - 20070037199 - Individual discriminating method, as well as array, apparatus and system for individual discriminating test The invention provides a method of individual discriminating. The method includes selecting and using single nucleotide polymorphism satisfying any one of the conditions defined by this invention. ... 02/15/07 - 20070037198 - Methods for genetic analysis Methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait, and for predicting the effectiveness of a drug treatment regimen in an individual. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to ... 02/15/07 - 20070037197 - In vitro recombination method The present invention relates, e.g., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising contacting the ... 02/15/07 - 20070037196 - Method for in vitro recombination The present invention relates, e.g., to an in vitro method, using isolated protein reagents, for joining two double-stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising (a) chewing ... 02/15/07 - 20070037195 - Light transmitted assay beads A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling ... 02/15/07 - 20070037194 - Allelic variation in the serotonin transporter (sert) as an indicator of autism The present invention describes allelic variations in the SERT gene that are linked with the development of autism. ... 02/15/07 - 20070037193 - Modulation of peroxisome proliferator-activated receptors A method of treating a peroxisome proliferators-activated receptors related disease by administering to a subject in need thereof an effective amount of a modulator of 15-keto prostaglandin-Δ13-reductase. Also disclosed are methods of identifying a compound for inhibiting activity of the reductase and of lowering blood glucose levels by administering to ... 02/15/07 - 20070037192 - Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile Methods of purifying antithrombin from a variety of source materials including from the milk of transgenic mammals to enhance its safety profile vis-à-vis the removal and/or the inactivation of contaminants. Contaminants would include particulate matter, viruses, and/or prions. ... 02/15/07 - 20070037191 - Apo-2dcr Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided. ... 02/15/07 - 20070037190 - Dna ligase mutants It is intended to obtain DNA ligase improved in binding ability and reactivity with DNA, particularly thermostable DNA ligase improved in binding ability and reactivity with DNA. The present invention provides a DNA ligase mutant improved in binding ability and reactivity with DNA, which is obtained by partially or completely ... 02/15/07 - 20070037189 - Methods for amplification monitoring and gene expression profiling, involving real time amplification reaction sampling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herein provide methods for monitoring the amplification of one sequence or ... 02/15/07 - 20070037188 - Methods for modulating transcriptional activation using mint proteins The present invention is directed to isolated nucleic acids encoding Mint protein variants having enhanced abilities to modulate the transcriptional activation mediated by the cytoplasmic tail of the amyloid precursor protein (APP) relative to wild-type Mint proteins. The present invention is further directed toward purified Mint protein variants having enhanced ... 02/15/07 - 20070037187 - Identification and quantification of a plurality of biological (micro)organisms or their components Disclosed is a system and method conducting real-time PCR. Unlabeled capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is ... 02/15/07 - 20070037186 - Thyroid fine needle aspiration molecular assay The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes. ... 02/15/07 - 20070037185 - Estimating allele frequencies by small pool pcr Methods of the invention include the application of fluorescent technology, total genome amplification, high throughput automated microsatellite fragment analysis, robotics, and novel computational methods. Computational methods include determining a microsatellite instability (MSI) phenotype (frequency and significance of MSI over multiple loci) using SP-PCR at higher than 0.5 genome equivalents (0.5 ... 02/15/07 - 20070037184 - Methods and kits for evaluating dna methylation Methods and kits are disclosed for determining the degree of methylation of at least one target region. Typically a sample is exposed to a modifying agent to obtain a modified sample comprising a modified nucleotide. At least one target region in the modified sample is amplified. Some of the disclosed ... 02/15/07 - 20070037183 - Diagnostic and therapeutic target for macular degeneration The present invention is based on the discovery of genetic polymorphisms that are associated with ocular diseases and disorders, such as age-related macular degeneration (AMD). In particular, the present invention relates to methods for determining an individuals susceptibility to ocular disorders such as AMD by screening for mutations and/or polymorphisms ... 02/15/07 - 20070037182 - Multiplex assays for inferring ancestry Oligonucleotide primers and probes for detecting Ancestry informative marker (AIMs) polynucleotides that contain a single nucleotide polymorphism or that contain an insertion or deletion, are provided, as are methods of using the oligonucleotide primers and probes to draw an inference as to a trait of an individual. The trait can ... 02/15/07 - 20070037181 - Compositions and methods for detecting pathogen specific nucleic acids in urine The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. ... 02/15/07 - 20070037180 - Site-specific immunization in order to establish antibodies with specificity for the e7 oncoprotein of high-risk hpv's The present invention relates to a method for establishment of antibodies with specificity for high-risk HPVs compared to immunization using the whole antigen of high-risk HPVs, wherein the method includes an exclusion of evolutionary conserved motifs as well as regions with high similarity to E7 proteins of low-risk HPVs, as ... 02/15/07 - 20070037179 - Methods of diagnosing and prognosticating solid tumors and melanoma The invention relates to the diagnosis and prognosis of solid tumors and melanoma by detecting increased cellular levels of A3 receptors in tissue and/or leukocytes obtained from patients with cancer or patients at risk for developing cancer. ... 02/15/07 - 20070037178 - Endocrine cell lines and method of using the same In accordance with the present invention, there are provided (1) var |