REGISTER now for FREE 
|
FREE patent keyword monitoring and additional FREE benefits. REGISTER now for FREE
|
 
|
|
Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test StripMeasuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.06/07/07 - 20070128585 - (+)-trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a ... 06/07/07 - 20070128584 - Method for isolation of cells A method is disclosed for separating selected cells that have cell membranes which are selectively-permeable to a given solute from other non-selected cells. The combination of cells are exposed to the given solute and thereafter the cells are exposed to low or zero-solute solution to thereby osmotically shock and destroy ... 05/31/07 - 20070122797 - System for tracking biological samples Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection ... 05/31/07 - 20070122796 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same A basement membrane having a barrier function is formed by culturing alveolar epithelial cells or vascular endothelial cells on a fibrous collagen matrix coated with a polymer having a sugar chain that can localize a receptor that has an activity to accumulate a basement membrane component on the basal surface ... 05/31/07 - 20070122795 - Information processing apparatus, information processing method, information processing system, program, and recording medium Disclosed herein is an information processing apparatus, method, system, and program, and a recording medium. An information processing apparatus includes an acquisition unit, an arithmetic unit, and an output control unit. The acquisition unit acquires the amount of the molecules for detection which have been produced by control cells and ... 05/24/07 - 20070117087 - Method of providing readily available cellular material derived from peripheral blood, and a compositoin thereof Method of researching disease states using TVEMF-expanded cells. ... 05/24/07 - 20070117086 - Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to ... 05/17/07 - 20070111199 - Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as ... 05/17/07 - 20070111198 - Nanopatterned surfaces and related methods for selective adhesion, sensing and separation Nanodimensioned heterogeneous surface compositions and configurations, related systms ad methods for sensing particle or analyte interaction therewith. ... 05/17/07 - 20070111197 - Sample analyzer and sample analyzing method A sample analyzer comprising: a measurement section for measuring a sample of an animal; a memory for storing a measurement data by the measurement section; an analysis section for analyzing the measurement data stored on the memory in accordance with a first analysis condition corresponding to a previous setting of ... 05/17/07 - 20070111196 - Sterilization of biosensors The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and ... 05/17/07 - 20070111195 - Toxicity typing using liver stem cells This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and ... 05/17/07 - 20070111194 - Method for the concentration and purification of biological compounds The invention concerns materials and methods used for the concentration, desalination, purification or stabilization of biological compounds, in particular biological macromolecules and supramolecular structures, by means of superabsorbent polymers or superabsorptive composite materials. ... 05/17/07 - 20070111193 - Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation. ... 05/17/07 - 20070111192 - Detection of protein interactions The present invention relates to a method of detecting interactions, particularly peptide to peptide interactions, using fluorescence. Nucleic acids encoding fragments of fluorescent protein, a peptide of interest and a linker portion of different lengths interposed between the peptide of interest and a fragment of fluorescent protein is provided together ... 05/10/07 - 20070105089 - Interactive transparent individual cells biochip processor An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location. ... 05/10/07 - 20070105088 - Light scattering determination of treatment potencies Potencies (44) of treatments effecting cells (11) are measured by difference (42) between angular intensity distributions of light scattered by treated cells and by untreated cells. ... 05/10/07 - 20070105087 - Biological tissue processing substrate, processing apparatus, processing method and processing kit A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of ... 05/10/07 - 20070105086 - Compositions and methods for identifying modulators of trpv2 It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2. ... 05/10/07 - 20070105085 - Crystal of a transporter-ligand complex and methods of use The invention relates to the three-dimensional structure of a crystal of a transporter protein complexed with a ligand. The three-dimensional structure of the transporter-ligand complex is disclosed. The transporter-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug ... 05/03/07 - 20070099176 - Methods of expressing lim mineralization protein Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding ... 05/03/07 - 20070099175 - Modified fluorescent proteins Functional red fluorescent proteins, nucleic acids encoding them, and methods for their use. ... 05/03/07 - 20070099174 - Rapid testing for nutrients This invention presents the rapid testing for nutrients in products including, but not limited, medicines, food supplements or additives, cosmetics, drinks, fruits, vegetables, and etc. The rapid testing is performed on strips coated with indicators. Nutrients such as Vitamin C can be detected in very small volume. The detection is ... 05/03/07 - 20070099173 - Electronic device for communication with living cells The present invention provides a surface-substrate for adherence of cells thereto. The surface-substrate comprises at least one micronail structure protruding from the surface, at least a region of the micronail having cellular-internalization promoting properties. The invention also provides an electronic device comprising a transistor structure, in which a gate electrode ... 04/26/07 - 20070092865 - Detection and characterization of psychoactives using parallel multi-site assays in brain tissue This invention relates to methods and devices for the detection and characterization of psychoactive compounds by analyzing alterations of network level physiological characteristics before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample. The invention further provides a software package that enables an operator ... 04/26/07 - 20070092864 - Treatment planning methods, devices and systems Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one ... 04/26/07 - 20070092863 - Methods and agents of decalcifying bone Decalcification can be performed by using acid or other agents. It may be difficult to decalcify large bone block within ours. This invention provides a bone-decalcifying agent including a calcium desolving agent for desolving calcium ions of bones, and a bubble-forming agent for generating microbubbles when the bone-decalcifying agent is ... 04/26/07 - 20070092862 - Flow sensors for penile tumescence The disclosure describes blood flow sensors for detecting penile tumescence. A system according to the invention may include at least one sensor for sensing blood flow into the penis, and one sensor for sensing blood flow away from the penis. Detecting penile tumescence may be accomplished by comparing the flow ... 04/26/07 - 20070092861 - Environments that maintain function of primary liver cells Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, lamninin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present ... 04/19/07 - 20070087329 - Serum replacement for thyroid hormone-responsive cell culture A low thyroid hormone serum supplemented culture medium is provided comprising serum prepared from non-mammalian vertebrates having a developmental stage with low endogenous thyroid hormone (T3 and T4) levels; and a culture medium. The culture medium is for the study of cellular responses to thyroid hormones or chemicals that induce ... 04/19/07 - 20070087328 - Method of coating lipid membranes Method for the manufacturing of a supported lipid membrane comprising: providing a substrate, covered at least in part with a layer comprising proteins, glycoproteins, polypeptides and/or peptides; contacting and incubating said substrate with a solution comprising bicelles, which comprise at least one short chain and at least one long chain ... 04/19/07 - 20070087327 - Method and kit-of-parts for the electrophysiological examination of a membrane comprising an ion channel The invention relates to a collection (kit-of-parts) for producing a high electrical resistance in an electrophysiological examination of a membrane comprising an ion channel, comprising a first electrolytic solution and a second electrolytic solution, wherein the first electrolytic solution comprises 20-140 mM divalent cations of a first element and the ... 04/19/07 - 20070087326 - Method of measuring the biological activity of an urotensin ii receptor Administration of U-II to a cell having a functional urotensin II receptor caused an increase in the electrical impedance of the cell in a receptor specific and dose dependent manner. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the electrical impedance ... 04/19/07 - 20070087325 - Method of screening for cell colonies that express a soluble variant of a target protein The present invention concerns a method of identifying a cell colony which expresses a soluble variant of a target protein which method comprises (a) subjecting the cell colony to conditions which are capable of causing lysis thereof; (b) filtering the lysate through a filter having pores which allow only soluble ... 04/12/07 - 20070082329 - Infertility assessment and treatment system A method for assessing fertility for a couple that includes obtaining semen analysis results from a male member of the couple, obtaining fertility survey responses from at least a female member of the couple, determining an initial location in a diagnostic matrix using the semen analysis results and the fertility ... 04/12/07 - 20070082328 - Rotatable time varying electromagnetic force bioreactor and method of using the same A rotatable time varying electromagnetic force bioreactor comprising a culture chamber having an interior portion that removably receives a cell mixture and an exterior portion with an electrically conductive coil wrapped around the exterior portion, a motor for rotating the culture chamber, and a time varying electromagnetic force source operatively ... 04/12/07 - 20070082327 - Cellular phenotype Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may ... 04/05/07 - 20070077552 - High throughput screen for inhibitors of polypeptide aggregation We have developed a high through-put screen capable of isolating inhibitors of polypeptide aggregation, such as Alzheimer's Disease polypeptide Aβ aggregation, or other disease state aggregating proteins, from amidst large libraries of candidate inhibitors. The screen uses a fusion of a polypeptide domain that self-aggregates, such as an Aβ42 domain ... 04/05/07 - 20070077551 - Sample analyzer A sample analyzer for analyzing samples of a plurality of species of animals, comprising: a display; a memory for storing first icon data representing a first icon and second icon data representing a second icon, the first icon showing a first species of animal and being used for selecting a ... 04/05/07 - 20070077550 - Sample imaging apparatus, sample analyzing apparatus, and sample imaging method A sample imaging apparatus comprising: a sample image obtainer for obtaining an image of a sample smeared on a sample holder, the sample holder comprising an identification part which comprises identification information of the sample; an identification detector for detecting the identification information; an identification part image obtainer for obtaining ... 04/05/07 - 20070077549 - Violet laser excitable dyes and their method of use The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates. ... 04/05/07 - 20070077548 - Method for determination of cardiovascular risk factors in dried blood A method for the determination of cardiovascular risk factors in biological samples that comprising the steps of a) sampling, b) altering the sample into a dry blood sample c) conducting a sample preparation where appropriate and d) analysing the sample to offer a simple yet effective method for the determination ... 04/05/07 - 20070077547 - Assay assembly A cell based assay assembly includes a biochip assembly, a liquid delivery unit and detection and recording equipment is used for conducting an assay on a biological cell as it is delivered through the biochip assembly. The biochip assembly includes a plurality of separate biochips each comprising a microchannel with ... 03/29/07 - 20070072172 - Liver specific chimeric regulatory sequence and use thereof The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5 flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other ... 03/29/07 - 20070072171 - Solid surface for biomolecule delivery and high-throughput assay The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules. ... 03/29/07 - 20070072170 - Methods of determination of responsiveness to erythropoietin treatment Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; comparing VHf to a predetermined criterion; and reporting indication of ... 03/29/07 - 20070072169 - Process and apparatus for measuring binding events on a microarray of electrodes There is disclosed a process and apparatus for reading electrical current of electrodes on a microarray of electrodes. Those electrodes having binding events are detected by a difference in electrical current flow. Enzymes on targets catalyze the conversion of substrate to product, which is detectable by electrochemical reduction at each ... 03/29/07 - 20070072168 - Microplate sample tracking system The invention provides sample tracking systems and methods. A sample tracking system can comprise a plate having a plurality of sample wells and an apparatus for illuminating each individual sample well, wherein the manner with which the sample well is illuminated can track the loading of the sample components to ... 03/29/07 - 20070072167 - Tissue binding composition The invention relates to a tissue binding composition. The inventive composition is characterised in that it comprises: between 40 g/l and 80 g/l trehalose, preferably approximately 60 g/l; between 40% and 80% (v/v) ethanol, preferably approximately 70% (v/v): between 0% and 5% (v/v) acetic acid, preferably approximately 1% (v/v); and ... 03/22/07 - 20070065808 - Method and apparatus for sorting particles A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing ... 03/22/07 - 20070065807 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; a method for constructing a specimen of a basement membrane; a process ... 03/22/07 - 20070065806 - Gel spot picker The present invention relates to a gel sheet (1) for use in a spot picker device wherein said gel sheet is provide with reference marks (5′-5′″) which can be used to determine if the gel sheet (1) has been deformed between the stages of scanning the gel sheet and picking ... 03/22/07 - 20070065805 - Cell migration assay The present invention provides compositions and methods for preparation of a three-dimensional transendothelial cell migration (TEM) assay. These compositions and methods are uniquely suited for the high throughput TEM assay, and for the analysis and identification of TEM mediators which inhibit or stimulate this process. The composition for detecting migration ... 03/22/07 - 20070065804 - Method for pr-39 peptide mediated selective inhibition of ikappabalpha degradation The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are ... 03/22/07 - 20070065803 - Patterns for a skeletal system The present invention relates to a bone system model comprising a mineralized matrix and osteoblasts, chararacterized in that the osteoblasts are deposited onto the matrix so as to form a layer at confluence and/or nodules, and the osteoclasts are deposited onto said layer and/or said nodules, and also to bone ... 03/22/07 - 20070065802 - Method and system for measuring the penetration of drugs and other substances into tissue The failure of many anticancer drugs to control growth of solid cancers may stem in part from inadequate delivery to tumor regions distant from vasculature. However, extricating the effect of tissue penetration from the many other factors that affect a drug's efficacy in tumors with distance from vasculature is generally ... 03/22/07 - 20070065801 - Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4) The invention provides a human 5-HT4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver ... 03/15/07 - 20070059680 - System for cell enrichment The present invention provides systems useful for the enrichment of analytes, for example, cells of selected types, including but not limited to blood cells, stem cells, and pathogens, in samples. The invention also provides methods for analyzing the condition of a patient based on characteristics identified through analysis of the ... 03/15/07 - 20070059679 - Method for demonstrating efficacy of a topically applied active ingredient A method is disclosed for demonstrating the efficacy of a topically applied active ingredient, which method includes topically applying a composition containing an active ingredient to an area of skin, applying an absorbent material to the area of skin to extract at least a portion of the active ingredient from ... 03/15/07 - 20070059678 - Breast milk contaminant detection device A breast milk detection device includes a plurality of test strips slidably and removably coupled to a test housing. Each test strip is connected to an absorbent section so that a breast milk sample deposited thereon is communicated to the test strips. Each test strip includes an analyte-specific moiety for ... 03/08/07 - 20070054261 - Methods for retail measurement of skin moisture content Methods provide for measuring scalp moisture content of a consumer. More particularly, the present invention is directed to a method comprising the steps of: (a) collecting input information from said consumer regarding a plurality of characteristics associated with hair and scalp condition of said consumer; (b) providing a moisture meter ... 03/08/07 - 20070054260 - Pharmacodynamic assays The invention provides methods for quickly and easily screening mixed cell samples for a pharmacodynamic effect to a drug or test agent. ... 03/08/07 - 20070054259 - Modulation of hnrnp h and treatment of dm1 The present invention is directed to the discovery that the heterogeneous nuclear ribonucleprotein H (hnRNP H) is capable of binding mutant myotonic dystrophy (DM) protein kinase (DMPK) mRNA. The present invention is also directed to the discovery that modulation of the expression of hnRNP H results in reduced nuclear retention ... 03/01/07 - 20070048734 - Novel enhanced processes for drug testing including neoplasmic tissue slices and products thereby A novel method for testing neoplasmic tissue in a testing system is more effective than conventional cell culture systems and functions by treating the neoplasmic tissue slice system's samples with at least one compound and observing the effect on the neoplasmic tissue slices resident therein, or cells, tissue samples or ... 03/01/07 - 20070048733 - Novel enhanced processes for drug testing and screening using human tissue A novel method for testing human tissue in a testing system is more effective than conventional cell culture systems and functions by treating the human tissue slice system's samples with at least one compound and observing the effect on the human tissue slices resident therein, or cells, tissue samples or ... 03/01/07 - 20070048732 - Chemosensitivity tester A novel method for testing the chemosensitivity of a substance in a bioartificial tissue slice system is more effective than conventional cell culture systems and function by treating the bioartificial tissue slice system's samples with at least one compound and observing the effect on the bioartificial tissue slices resident therein, ... 03/01/07 - 20070048731 - High throughput use-dependent assay based on stimulation of cells on a silicon surface The invention pertains generally to the field of drug discovery science. More specifically, the invention refers to a drug screening assay and device that is used to test the effect of specific chemical compounds as use dependent ion channel blockers. The invention includes a unique method for stimulating cells with ... 03/01/07 - 20070048730 - Global alignment of sequence data To determine optimal alignment of two molecules, an alignment space of two strings representing element sequences of the molecules is conceived as a grid of cells, where each cell represents alignments between substrings of the two strings. The cells are tested against conditions that are framed, in the context of ... 03/01/07 - 20070048729 - Method of creating a collection of biological specimens, and collection of specimens The invention relates to a method of creating a collection of isolated biological specimens, wherein each isolated biological specimen is preserved within a defined length of time following isolation of the specimen from its natural environment and is subsequently stored, and wherein the defined length of time between isolation and ... 03/01/07 - 20070048728 - Hydroxylases and modulators thereof A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates ... 02/22/07 - 20070042347 - High throughput biological heart rate monitor that is molecularly determined This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and ... 02/22/07 - 20070042346 - Method and apparatus for detection of rare cells Fluorescent dye-tagged rare cells are disposed in a biological fluid layer contained in an annular gap (12) between an inside test tube wall (14) and a float wall (16). One or more analysis images are acquired at one or more focus depths using a microscope system (10, 10′, 10″, 10′″). ... 02/22/07 - 20070042345 - Polypeptide having intracellular calcium ion indicator function The present invention provides a polypeptide having an intracellular calcium ion indicator function, which contains the following elements (a)-(c): (a) a polypeptide residue consisting of a membrane localization signal sequence; (b) a first fluorescent polypeptide residue; and (c) a second fluorescent polypeptide residue in the order of (a), (b) and ... 02/22/07 - 20070042344 - Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient The present invention relates to a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into natural killer cells as an effective ingredient, more precisely, a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into premature natural killer cells as an effective ingredient ... 02/22/07 - 20070042343 - Forward mutation assay based on 5-fluorouracil resistance Disclosed herein is a novel forward mutation assay based on 5-fluorouracil (5-FU) resistance which utilizes a strain of Salmonella typhimurium derived from the Ames strain TA100. More specifically, the invention provides a high throughput alternative to the standard Ames mutation assay for the evaluation of the genotoxicity activity of compounds ... 02/15/07 - 20070037136 - Method of preparing cell cultures from biological specimens for assaying a response to an agent An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly ... 02/15/07 - 20070037135 - System and method for the identification and quantification of a biological sample suspended in a liquid A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at ... 02/15/07 - 20070037134 - Functional coupling of t1rs and t2rs by gi proteins, and cell-based assays for the identification of t1r and t2r modulators The invention resides in part in the discovery that G proteins other than Gα15 couples to T1R and T2R taste receptors, particularly Gi proteins such as Gαi. Related to this discovery, the invention provides cell-based assay methods for identifying compounds that modulate the activity of specific T1R or T2R taste ... 02/15/07 - 20070037133 - Method and apparatus for use of thermally switching proteins in sensing and detecting devices An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance ... 02/08/07 - 20070031821 - Screening molecules with anti-prion activity: kits, methods and screened molecules A kit and a method for identifying compounds having anti-prion activity are provided. The kit comprises a yeast of phenotype [PSI+]; an antibiogram; and a prion curing agent in a sub-effective dose, wherein the yeast has the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene. Compounds and ... 02/08/07 - 20070031820 - Specific bacterial inclusions in bone marrow cells indicate systematic lupus erthematosus, and treatment for lupus A method for diagnosing for the presence of systemic lupus erythematosus (SLE) in a patient is disclosed. In accordance with this method, megakaryocytes present in bone marrow of a person suspected of having SLE are assayed for the presence of internal bacterial structures that specifically stain with an intercalating dye. ... 02/08/07 - 20070031819 - Microfluidic systems for biological and molecular analysis and methods thereof Disclosed herein are systems, components, devices and methods for automated yeast pedigree analysis. Systems, components, devices and methods for analyzing microorganisms, cells, particles and molecules are also disclosed. ... 02/08/07 - 20070031818 - Assay for distinguishing live and dead cells Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is ... 02/08/07 - 20070031817 - Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with ... 02/08/07 - 20070031816 - Mounting device for mounting a retainer means for a biological object and corresponding method for laser micro-dissection To enable contactless laser microdissection in a closed container (10, 11), for example in the form of a Petri dish, it is proposed according to the invention to use a holding device which comprises a receiving portion (4) for arrangement in the container (10, 11) and a holding portion (1) ... 02/08/07 - 20070031815 - Screening method for identifying hsp90 modulators A screening method for identifying and/or analysing Hsp90 inhibitors and/or Hsp90 agonists comprises the steps of contacting a compound with at least two of yeast strains A-E wherein each yeast strain comprises expression vectors from which a pair of binding partners for a yeast two-hybrid assay are expressed. The binding ... 02/08/07 - 20070031814 - Methods of modulating and identifying agents that modulate intracellular calcium Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium. ... 02/08/07 - 20070031813 - Method of examining cell An object of the present invention is to provide a more accurate diagnostic method of a tissue or a cell for carrying out definite diagnosis of cancer, drug resistance test and prognosis. More accurate examination of cancer tissues or cancer cells is enabled by a method of the examination of ... 02/01/07 - 20070026385 - Marker for antidepressant therapy and methods related thereto The present invention relates generally to methods for determining the effectiveness of ongoing antidepressant therapy via analysis of the association of Gsα with components of the plasma membrane or cytoskeleton of cells from peripheral tissues of the depressed individual as well as to methods involved in screening for effective antidepressant ... 02/01/07 - 20070026384 - Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in ... 02/01/07 - 20070026383 - Methods and compositions for extracting membrane proteins The present invention provides methods and compositions for the isolation and use of membrane proteins and other membrane associated molecules (e.g., peptides, carbohydrates, lipids, or combinations thereof). In particular, the present invention provides amphiphilic polymer compositions and methods of using the compositions to solubilize, enrich and isolate components of biological ... 02/01/07 - 20070026382 - Cytometer on a chip An assay technique for label-free, highly parallel, qualitative and quantitative detection of specific cell populations in a sample and for assessing cell functional status, cell-cell interactions and cellular responses to drugs, environmental toxins, bacteria, viruses and other factors that may affect cell function. The technique includes a) creating a first ... 02/01/07 - 20070026381 - Devices and methods for enrichment and alteration of cells and other particles The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present ... 02/01/07 - 20070026380 - System for water removal and solvent evaporation An apparatus and method for separating residual water from a solvent and removing a solvent. The apparatus may be sealed and automated. The method comprises providing a solution comprising solvent and residual water and an analyte. The solution may be passed through a membrane to reduce water content wherein an ... 01/25/07 - 20070020613 - Devices and methods for pharmacokinetic-based cell culture system Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ... 01/25/07 - 20070020612 - Method of measurement of cellular hemoglobin A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the ... 01/25/07 - 20070020611 - Hematology reference control containing an immature granulocyte component A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of ... 01/25/07 - 20070020610 - Methods for ex vivo propagation of adult hepatic stem cells The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. ... 01/25/07 - 20070020609 - Method of determining and prognosing severity of pregnancy toxemia and method of estimating fetus/placenta function under pregnancy toxemia Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for ... 01/25/07 - 20070020608 - Method for the generation of neural progenitor cells A rapid, simple and efficient method for the generation of neural progenitor cells from pluripotent/undifferentiated human blastocyst-derived stem (hBS) cells, neural progenitor cells obtained by the method and further differentiation of these cells into the three neural cell lineages, and the use of the neural progenitor cells and the differentiated ... 01/18/07 - 20070015138 - Methods for identifying agents and conditions that modulate neurogenesis Methods and tools for identifying agents and conditions that modulate neurogenesis are disclosed. The disclosure also relates to methods and tools for identifying populations of neural stem cells suitable for transplantation. ... 01/18/07 - 20070015137 - Microfluid device and method of producing diffusively built gradients A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir, ... 01/18/07 - 20070015136 - Controlling dendritic cell maturation state in the lymphoid tissue equivalent of an artificial immune system The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates ... 01/18/07 - 20070015135 - Methods and computer systems for analyzing high-throughput assays The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the ... 01/18/07 - 20070015134 - Quantitative stabilized cell reference control products and methods The invention relates to quantitative stabilized cell reference control products, their methods of manufacture, and their methods of use. Receptors, antigens, and ligands associated with stabilized cells may be quantitated by the methods of the present invention. Those quantitated stabilized cells may then be used to determine the receptor, antigen, ... 01/18/07 - 20070015133 - Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-β structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides ... 01/18/07 - 20070015132 - System and methods for measuring at least one metabolic rate of a plurality of cells A system and methods for calculating at least one unknown metabolic flux of a plurality of cells. In one embodiment, the method includes the steps of constructing a metabolic network having a plurality of reaction components, the reaction components representing at least glycolysis, reduction of pyruvate to lactate, TCA cycle, ... 01/11/07 - 20070009883 - Low fluorescence assay platforms and related methods for drug discovery One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform ... 01/11/07 - 20070009882 - In vitro platform for screening agents inducing islet cell neogenesis The present invention relates to an in vitro method for screening agents inducing islet cell neogenesis or duct-to-islet cell transdifferentiation, which comprises the steps of: a) expanding in vitro cells of a duct-like structure obtained by inducing cystic formation in cells in or associated with post-natal islets of Langerhans; b) ... 01/04/07 - 20070003922 - Diagnostic biomarkers for neurodevelopmental disorders The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using cytometry and mass spectrometry. The invention further provides methods of using the identified biomarkers to diagnose the presence of a neurodevelomental disorder, including an autism ... 01/04/07 - 20070003921 - Method of grading disease by fourier transform infrared spectroscopy The infrared spectrum of cells or tissues in the frequency range 900cm−1-1750cm−1 is digitally separated by the method of the invention into the component contributions by protein, RNA and DNA. By comparing the relative sizes of the component spectra, relative quantities of these components can be specified. The ratios protein/DNA ... 12/28/06 - 20060292550 - Method for determining fish composition using bioelectrical impedance analysis A method for determining the freshness of fish. The method includes applying electrodes to the fish, passing an electrical current between the electrodes, determining an impedance for tissue of the fish between the electrodes, and correlating the determined impedance with a freshness value to determine the freshness of the fish. ... 12/28/06 - 20060292549 - Psychotropic drug screening device based on long-term photoconductive stimulation of neurons The invention pertains generally to the field of psychotropic drug discovery and neuroscience. More specifically, the invention refers to a device that allows the long-term stimulation of cultured neurons grown on a silicon die, thereby replacing the use of intact animal models. The device consists of a controlled sterile environment ... 12/28/06 - 20060292548 - Trp8, a transient receptor potential channel expressed in taste receptor cells The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion ... 12/28/06 - 20060292547 - Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of ... 12/28/06 - 20060292546 - Herg channel-expressing cell It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high ... 12/28/06 - 20060292545 - Moleculary imprinted polymers for extraction of components from foodstruffs The present invention relates to a novel class of water compatible molecularly imprinted polymers (AquaMIPs) capable of selectively binding target molecules such as riboflavin, or analogues thereof, in water or aqueous media, their synthesis and use thereof in food processing and extraction or separation processes. ... 12/21/06 - 20060286544 - Establishment of a human embryonic stem cell line using mammalian cells Purified preparations of human embryonic stem cells with certain population-specific characteristics are disclosed. This preparation is characterized by the positive expression of the following pluripotent cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); alkaline phosphatase (+), as well as a set of ES cell markers including Oct-4, ... 12/14/06 - 20060281071 - Stearoyl-coa desaturase assay A yeast-based method for identifying an agent that can modulate the activity of a human or mouse stearoyl-CoA desaturase (SCD) is disclosed. Further disclosed are substrate specificities of various human and mouse SCDs, which facilitate the identification of modulators for human and mouse SCDs. ... 12/14/06 - 20060281070 - Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in ... 12/14/06 - 20060281069 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 12/14/06 - 20060281068 - Cytological methods for detecting a disease condition such as malignancy by raman spectroscopic imaging Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment ... 12/14/06 - 20060281067 - Microluminometer chip and method to measure bioluminescence An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the ... 12/07/06 - 20060275745 - Method for optically determining dynamic behaviour of contracting muscle cells The invention refers to a method for optically determining the dynamic behaviour of contracting muscle cells, such as cardiomyocytes in a cell culture, for example, wherein a video sequence of the contracting muscle cells is made using a video camera (3), an image processing unit (4) is used to calculate ... 12/07/06 - 20060275744 - Modified human embryonic stem cells and methods of use to treat neuron-associated disorders The invention is directed to methods for promoting the differentiation and maturation of embryonic and adult stem cells to dopamine neurons by increasing expression of the transcription factors Nurr1 and PitX3 in the stem cells. The invention provides embryonic and adult stem cells expressing Nurr1 and PitX3 from nucleic acid ... 12/07/06 - 20060275743 - Counting, viability assessment, analysis and manipulation chamber A transparent plastic slide has a recessed chamber which receives a transparent plastic cover. The cover has a fluid inlet opening which overlies a recessed center well in the slide. The well has a sloping ramp which extends to a viewing platform which has a surface which is closely spaced ... 11/30/06 - 20060269909 - Screening assay for improvement of epithelial barrier function The present invention relates to the use of an air-liquid interface culture model using asthmatic bronchial epithelial cells, which exhibit impaired epithelial barrier function. It is proposed to use asthmatic epithelial cultures, in the absence of added Th2 or proinflammatory cytokines such as IL-13, as an in vitro model to ... 11/23/06 - 20060263763 - Analyte sensing biointerface Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a ... 11/23/06 - 20060263762 - Cytoskeletal integrity testing as a filter for creating homogeneous samples for further analysis The present invention is generally directed to the integration of cytoskeletal manipulation with genetic and proteomic analysis. “Cytoskeletal manipulation” references any technology that uses either cytoskeletal integrity or cell adhesion to isolate symptomatic cells from asymptomatic cells as a gatekeeping step for genetic and proteomic analysis. As used in the ... 11/23/06 - 20060263761 - Methods and compositions for beryllium-induced disease The present invention provides for methods for detection, diagnosis and prognosis of beryllium-induced disease. In one embodiment, the methods include exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing the Th-1 cytokines produced. Other embodiments include the use of exposing immune cells from subjects suspected ... 11/23/06 - 20060263760 - Screening method of substance with antidepressant action There is provided a rapid and simple screening method of a substance with an antidepressant action. The screening method of a substance with an antidepressant action in accordance with the invention includes a cell preparation step for preparing a cell showing a predetermined electrophysiological response on a given stimulation and ... 11/16/06 - 20060257848 - Methods of preventing or treating cell migration mediated conditions or diseases The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or disease in a subject are also provided. ... 11/16/06 - 20060257847 - Magnetic separation apparatus and methods Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic capture structure may be on the transparent collection wall ... 11/16/06 - 20060257846 - Method of assaying for high performance mammals A method of assaying for animals having a high innate immunity level by assessing the total white blood cell count of the mammal or at least one of the mammal's parents and/or the acute phase protein level of the mammal or at least one of its parents. Alternatively, genetic markers ... 11/16/06 - 20060257845 - Cosmetic treatment of xerosis A method for decreasing the level of skin ashiness in an individual with xerosis and having a Fitzpatrick type 4 or higher score comprising topically applying to the skin of said individual a composition (a) having a cleansing surfactant or mixture of cleansing surfactants in quantity sufficient to cleanse the ... 11/09/06 - 20060252027 - Cellulosic-based resistance domain for an analyte sensor The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain. ... 11/02/06 - 20060246419 - Layered support sheet for high-yield spot cutting from gels or membranes The excision of sample spots from a gel or membrane by pressing a cutting tool terminating in a hollow cylinder against the gel or membrane supported on a rigid surface is made more reliable by interposing a relatively pliable, intermediate layer on the side of the surface facing the gel ... 11/02/06 - 20060246418 - Method for screening compounds & uses therefor In accordance with the present invention, it has been discovered that glucose and incretin hormones promote pancreatic islet cell survival via the calcium and cAMP dependent induction, respectively, of the transcription factor CREB. Specifically, a signaling module has been identified which mediates cooperative effects of calcium and cAMP on islet ... 11/02/06 - 20060246417 - System for functional analysis of polypeptides The present application discloses a polypeptide assay system that includes a non-mammalian cell in a non-mammalian cell culture medium expressing a heterologous polypeptide that is either displayed on its cell surface such that the polypeptide is the predominant polypeptide displayed on the cell surface or the polypeptide is secreted, and ... 11/02/06 - 20060246416 - On-chip bioassay method and kit The present invention provides an on-chip bioassay system which reduces preoperations including culture, and is highly versatile and capable of conducting high throughput analyses. A microfluidic chip for introducing a cell is fixed on the undersurface of a microporous chip composed of a substrate through which a plurality of micropores ... 11/02/06 - 20060246415 - Methods for detection of breast cancer The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without ... 10/26/06 - 20060240404 - Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle ... 10/26/06 - 20060240403 - Tape magazine for a hand-held device The present invention concerns a tape magazine especially for a hand-held device for analysing a body fluid with a test tape that can be unwound from a storage unit and wound onto a waste unit where the waste unit can be driven in order to wind forward the test tape. ... 10/26/06 - 20060240402 - Marine invertebrate gametes and embryos as an assay system for therapeutic screening The invention provides methods of using of marine invertebrate gametes and preparations thereof for drug discovery and therapeutic screening. ... 10/26/06 - 20060240401 - Handheld raman body fluid analyzer Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface ... 10/26/06 - 20060240400 - High-density cell array board, process for producing the same and method of using the same Culture substrates, cell arrays, automatic chemical dispensers and assay systems necessary for conveniently assaying multiple chemicals such as drugs and toxic agents are provided. Herein used is a substrate for a high-density cell array characterized in that it has a surface comprising an ordered array of discrete microdomains coated with ... 10/19/06 - 20060234207 - Device for evaluating in vitro cell migration under flow conditions, and methods of use thereof The current invention is directed towards a device that useful for studying cell migration. It is preferred that the device is configured to study stem cell, particularly hematopoetic stem/precursor cell homing. The device allows for detailed analysis of the various phases of the multiphase homing process. There are also provided ... 10/19/06 - 20060234206 - Fluorescent probes for biological studies and methods monitoring protein-protein interactions. ... 10/19/06 - 20060234205 - In vitro test system for predicting patient tolerability of therapeutic agents Methods for predicting patient tolerability to therapeutic agents, such as cytokines, lymphokines and immunotoxins, are disclosed. The methods utilize an in vitro model of vascular leak syndrome (VLS) to assess the effect of the agent in question on the permeability of large proteins across confluent monolayers of endothelial cells (EC). ... 10/12/06 - 20060228695 - Predicting hepatotoxicity using cell based assays Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, ... 10/12/06 - 20060228694 - Methods to individualize combination therapy Compositions which comprise delivery vehicles having stably associated therewith predetermined, patient-specific combinations of two or more agents, such as antineoplastic agents, are useful in achieving optimal therapeutic effects on a patient-by-patient basis when combinations of drugs are administered. ... 10/05/06 - 20060223051 - System and method for performing g protein coupled receptor (gpcr) cell assays using waveguide-grating sensors The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells ... 09/28/06 - 20060216690 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/28/06 - 20060216689 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/28/06 - 20060216688 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/21/06 - 20060210964 - Prevention and treatment of amyloid-associated disorders The present invention provides assays to identify compounds that affect microglial cell activation, and specifically assays to identify compounds that affect secretion of cytokines from these microglial cells by modulating PGE2-mediated activity. The assays of the invention include assays for testing microglial cell activation by contacting microglia with compounds that ... 09/21/06 - 20060210963 - Induction of a beta cell differentiation in human cells The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are ... 09/21/06 - 20060210962 - Cell observation device and cell observation method The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a ... 09/21/06 - 20060210961 - Method and system for analysing a liquid sample discharging reagents located in the reaction loop (42). The present invention also relates to a system for analyzing a liquid sample. ... 09/14/06 - 20060204953 - Method and apparatus for automated analysis of biological specimen Apparatus and methods for automatic classification of cells in biological samples is disclosed. Aggregation parameters of identified objects are calculated using relative spatial positions of the objects, and the aggregation parameters are used in the classification. Centres of cells may be located using an edge detector and parameterisation across at ... 09/14/06 - 20060204952 - Technique for measuring cell-membrane properties in cultured cells grown on biomaterials in an ussing chamber The present invention is directed to a system and method which measures transcellular parameters in which cells are cultured in a monolayer on a biomaterial. The parameters measured are indicative of in vivo values such as cell-cell and cell-matrix adhesion parameters. ... 09/14/06 - 20060204951 - Platelet biomarkers for the detection of disease The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other ... 09/07/06 - 20060199173 - Device and method for characterizing spheroids The present invention relates to a device and a method for characterizing spheroids. The to-be-characterized spheroid is introduced into a tube of an electrically insulating material and with an inner diameter which is smaller than the diameter of the to-be-characterized spheroid in such a manner that the latter is in ... 09/07/06 - 20060199172 - Laminated cell culture containing hepatocytes and method for detecting endocrine-like substance A laminated cell culture obtained by lamination of a cell layer containing hepatocytes and a cell layer containing one or more kinds of cells selected from the group consisting of vascular endothelial cells, vascular smooth muscle cells, adipocytes, hemocytes, and macrophages; a laminated cell culture system obtained by lamination of ... 09/07/06 - 20060199171 - Assays for tert promoter modulatory agents Methods and compositions for assaying an agent for TERT promoter modulatory activity are provided. In the subject methods, an agent is contacted with a normal cell under assay conditions that provide for a detectable phenotype, e.g., cell death, upon modulation of TERT promoter transcription control activity. Also provided are compositions, ... 09/07/06 - 20060199170 - Ferromagnetic cell and tissue culture microcarriers A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also provided is a method for creating batches of microcarriers which have inserted within them magnetite (Fe3O4) in the presence of collagen, thus creating a ... 09/07/06 - 20060199169 - Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation unit for performing the production of the tissue column ... 09/07/06 - 20060199168 - Cell recovery The present invention relates to apparatus for recovering selected particles having predetermined properties from a number of particles. The apparatus includes a stimulation system, a detection system, a retriever and a control system. In use, the control system is adapted to activate the stimulation system to attempt to stimulate one ... 08/31/06 - 20060194194 - Diagnostic measurement of disease Diagnostic systems and methods that can be used to perform direct tests on immune system or other proliferative cells, which are capable of identifying abnormal cell function associate with disease without use of labeled reagents; that also permit, but do not require provision of an autoantigen; that are capable of ... 08/31/06 - 20060194193 - Biological sample culturing and observation system, incubator, supplying device, and culture vessel The present invention provides a biological sample culturing and observation system which includes: an incubator in which a biological samples are housed, and whose interior is maintained in a culturing environment satisfying predetermined conditions, and the interior is isolated from the outside; an observation optical system that from outside the ... 08/24/06 - 20060188870 - Identification of active sites in enzymes A method for determining the location of the active site of an enzyme is provided. The method comprising: determining a location of a reference point inside a functional unit of the enzyme; determining a limiting distance from the reference point; and identifying one or more molecular surface portions within the ... 08/24/06 - 20060188869 - Method and apparatus for uv imaging A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with ... 08/24/06 - 20060188868 - Direct detection method for products of cellular metabolism using tof-sims A rapid and efficient method for novel biological substance screening by surface analysis has been developed using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). This method relies on the surface screening of an array of micro-organisms grown on porous membranes, which had previously been in contact with a solid growth medium. ... 08/17/06 - 20060183105 - Human brain-derived tissue-specific potassium channel A novel human brain-derived potassium channel polypeptide is described which is developmentally regulated and tissue-specific to differentiated neurons. A full length cDNA which encodes the novel potassium channel polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the human brain potassium channel ... 08/17/06 - 20060183104 - Cellular models of neuron-associated disorders and uses thereof The present invention describes two new cell lines derived from embryonic stem cells and useful for analyzing and studying neuron-associated disorders. The present invention further relates to methods of analyzing stem cell differentiation, and methods of identifying new therapies for neuron-associated diseases ... 08/10/06 - 20060177816 - Cellular rhogtpase activation assay The invention relates to a cellular RhoGTPase activation assay based on the determination of changes in the actin cytoskeleton (actin cytoskeletal rearrangement assay); to the recombinant cell lines used to carry out this assay; to the constructs required to produce these cell lines; to the use of these recombinant cell ... 08/10/06 - 20060177815 - Dielectrophoretic particle sorter Provided are methods, devices and systems that utilize dielectrophoretic forces to separate a target species from a plurality of species in a sample. ... 08/10/06 - 20060177814 - Systemic lupus erythematosus This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose ... 08/10/06 - 20060177813 - Novel high-throughput screening method of drug for bioactive protein The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have strenuously studied to solve the matters above ... 08/10/06 - 20060177812 - Method and device for manipulating samples The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (2) for punching holes (34) in sample carriers (4) and at least one further needle (3) for punching samples out of preparations (5), wherein a device for detecting the ... 08/03/06 - 20060172280 - System for monitoring cell motility in real-time The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper ... 08/03/06 - 20060172279 - Cell-based sensing: biological transduction of chemical stimuli to electrical signals (nose-on-a-chip) Methods and compositions for the reliable detection of chemical stimuli using a “nose-on-a-chip” are presented. The invention uses cells sensitive to chemical stimuli and detects and processes the signals given by the cells upon contact with chemical stimuli. ... 08/03/06 - 20060172278 - Target activated microtransfer A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a ... 08/03/06 - 20060172277 - Method for determining the influence of a test substance on the heart activity of a vertebrate In a method for determining the influence of a test substance on the heart activity of a vertebrate the following steps are performed: a) preparation of a culture of spontaneously active heart cells of the vertebrate, b) extracellular measurement of electrophysiological data of the heart cells from step a), c) ... 07/27/06 - 20060166185 - System for and method of patch clamp analysis A system and method for automated patch clamp analysis of biological tissue such as cellular membrane. A biological membrane is applied to a porous semiconductor substrate, and laser energy is imparted thereon. Voltage clamped electrodes detect current across the membrane to indicate ion channel activity. ... 07/27/06 - 20060166184 - Apparatus for cell reaction examination and method of cell reaction examination Disclosed herein are an inspection apparatus for cell reaction by a device for liquid processor, which can set a fluid running route to a cell reaction site required according to the kind of an inspection of a cell reaction to be conducted with a great degree of freedom, and an ... 07/27/06 - 20060166183 - Preparation of coatings through plasma polymerization The invention provides a method to prepare at least part of at least one surface of a substrate comprising; depositing on said surface at least one plasma monomer wherein during deposition of said monomer, means are provided which move the monomer source across a surface to be treated to manufacture ... 07/20/06 - 20060160066 - Cellular microarrays for screening differentiation factors Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel. ... 07/20/06 - 20060160065 - Method for classifying plant embryos using raman spectroscopy A three-step method for classifying plant embryo quality using Raman spectroscopy is provided. First, a classification model is developed based on Raman spectral data of reference samples of plant embryos or any portions of plant embryos of known embryo quality. The embryo quality may be known based on a comparison ... 07/20/06 - 20060160064 - Devices and methods for removing target agents from a sample The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample. ... 07/20/06 - 20060160063 - Method of screening physilogically active substance The present invention relates to a method of screening a physiologically active substance, comprising the steps of (1) contacting a transformed yeast with a test sample, wherein the transformed yeast is capable of expressing a heterogeneous protein, and shows a change in a growing state in an expression state of ... 07/13/06 - 20060154236 - Computer-assisted analysis The present invention provides methods and systems for automated morphological analysis of cells also known as phenotypic screening. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen or in the screening for agents with a particular mechanism of action. Agents which cause ... 07/13/06 - 20060154235 - Human hepatocyte-like cells and uses thereof The present invention provides modified methods of producing human hepatocyte-like cells which exhibit phenotypes more similar to those of human hepatocytes. The present invention also provides the human hepatocyte-like cells and uses thereof. The methods of the present invention comprises a prolonged incubation period and addition of dexamethasone to the ... 07/13/06 - 20060154234 - Standard Disclosed is a reference standard for a detectable entity, the reference standard comprising a support medium, such as an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a biological, such ... 07/13/06 - 20060154233 - Method and device for manipulating individual small objects A method for individually moving small objects, such as cells, from one location to another as well as a device for implementing the method is disclosed. A small object such as a cell is isolated at some initial location and moved to some destination location by the movement of the ... 07/06/06 - 20060147904 - Use of resveratrol to regulate expression of apolipoprotein a1 Described are new methods for promoting the expression of apolipoprotein A1 (APO A1) for increasing levels of HDL, and assays for screening and identifying compounds for regulating expression of the APO A1 protein. ... 07/06/06 - 20060147903 - In vitro organ modeling with cell culture tool A method of culturing different cell types from a single organ in a cell culture tool having more than one well includes depositing the different cell types from the single organ in separate wells, culturing the different cell types in the separate wells and filling the cell culture tool to ... 07/06/06 - 20060147902 - Yeast screens for treatment of human disease Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein ... 07/06/06 - 20060147901 - Devices and methods to image objects by time delay integration Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDI technology into ... 07/06/06 - 20060147900 - Compositions and methods for determining oocyte development potential The present invention relates to the field of reproduction (e.g., human reproduction). In particular, the present invention provides markers (e.g., pentraxin 3 and Annexin A6), and methods of using the same to determine oocyte development potential. The present invention also provides compositions and methods for modifying oocyte development potential and ... 07/06/06 - 20060147899 - Multicellular metabolic models and methods The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of ... 07/06/06 - 20060147898 - Cell microchip A cell microchip with which various measurements of the action of medicaments, etc. by the use of biological reaction using a small amount of cells can be accomplished simply within a brief period of time; and a method of assay with the use of the cell microchip. In particular, there ... 07/06/06 - 20060147897 - Characterization of arteriosclerosis by optical imaging A method and system for detecting abnormalities in the properties of the walls of a subject's blood vessels by observing the characteristics of blood flow in vessels which are optically accessible, such as the retinal vasculature. A time sequenced series of images is taken, and the images are processed to ... 07/06/06 - 20060147896 - Method and device for manipulating samples The invention relates to a method and a device for manipulating samples, in particular tissue samples, with at least one needle (3) for punching samples from preparations (5), in particular prepared tissue specimen, at defined positions and a control device (13) to control the needle (3). The aim of the ... 06/29/06 - 20060141449 - Yeast screens for treatment of human disease Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein ... 06/29/06 - 20060141448 - Whole cell assay This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods. ... 06/29/06 - 20060141447 - Cell culture media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells. ... 06/29/06 - 20060141446 - Substrates, devices, and methods for cellular assays The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention ... 06/29/06 - 20060141445 - Method for manufacturing a sensor chip and sensor chip blank In a process for manufacturing a sensor chip a support is prepared having at least one surface region in which at least one reactive group is arranged. A buffer solution is applied to the surface region for coating at least one surface region. Then, at least one receptor having binding ... 06/29/06 - 20060141444 - Adherent entities and uses therefor The present invention is directed to reproductive function-modulating organisms especially of the genera Ureaplasma and Mycoplasma, which adhere more strongly to spermatozoa than other organisms and which correlate with the presence or risk of a condition selected from male infertility, an adverse pregnancy outcome or an adverse assisted reproductive technology ... 06/29/06 - 20060141443 - Apparatus and method for transcellular testing The present invention relates to a device and method for facilitating high throughput transcellular flux testing of compounds, such as pharmaceuticals or drugs, other compounds, or compound combinations. In one embodiment, the system and methods of the present invention may be used to identify the optimal components (e.g., solvents, carriers, ... 06/22/06 - 20060134605 - Platelet biomarkers for the detection of disease The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other ... 06/22/06 - 20060134604 - Flexible method and apparatus for high throughput production and purification of multiple proteins A plurality of proteins of interest, or peptides of interest, or other genetically expressed materials, are screened and subsequently produced using any of a variety of expression systems. The plurality of proteins are extracted from a plurality of separate, processed green juices, each green juice containing one of the proteins ... 06/22/06 - 20060134603 - Automated extraction and purification of samples using optical tweezers An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; ... 06/22/06 - 20060134602 - Methods of identifying cytotoxic effects in quiescent cells The present invention provides a system for measuring the cytotoxicity of a test compound against quiescent cells. The inventive methods and reagents may also be used to determine whether a compound, such as a chemotherapeutic agent, will have undesired toxicity toward normal tissues, which generally do not include a significant ... 06/22/06 - 20060134601 - Osmotic reaction detector for detecting biological and non-biological reactions A method and apparatus for measuring the presence or absence of interaction between at least a first and second material of interest by measuring osmotic pressure changes in an osmotic cell. Changes in osmotic pressure are determined by measuring the amount of compression exhibited by a compressible, semi-permeable material positioned ... 06/22/06 - 20060134600 - Method and devices for non-traumatic movement of a probe through biological cell material A method for moving a probe (10, 91) through a cell material (20), which is formed from biological cells (21), is described, the probe (10) displacing the cells (21) without injury. A probe (10, 91) for performing the method and a cell manipulator, which is equipped with at least one ... 06/22/06 - 20060134599 - Microfluidic device for cell separation and uses thereof The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a mixture of ... 06/15/06 - 20060127884 - Toll-like receptor 9 modulators TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of ... 06/15/06 - 20060127883 - Spatially directed ejection of cells from a carrier fluid This invention is directed to the use of focused energy, particularly focused acoustic energy, in the spatially directed ejection of cells suspended in a carrier fluid, e.g., for providing a pattern of cells on a substrate surface, such as a cellular array. ... 06/15/06 - 20060127882 - Circuit and method to non-invasively detect the electrical potential of a cell or neuron A system and method for non-invasively measuring the electrical potential radiated by a cell. To do this, a probe is positioned within ten microns distance from the cell for receiving the signal. Also, a reference potential is determined for the cell's environment. A sensor records the signal and compares the ... 06/15/06 - 20060127881 - Automated segmentation, classification, and tracking of cell nuclei in time-lapse microscopy Methods and apparatus are provided for the automated analysis of images of living cells acquired by time-lapse microscopy. The new methods and apparatus can be used for the segmentation, classification and tracking of individual cells in a cell population, and for the extraction of biologically significant features from the cell ... 06/15/06 - 20060127880 - Computerized image capture of structures of interest within a tissue sample A computerized method of automatically capturing an image of a structure of interest in a tissue sample. The computer memory receives a first pixel data set representing an image of the tissue sample at a low resolution and an identification of a tissue type of the tissue sample, and selecting ... 06/15/06 - 20060127879 - Electrodynamic profiling of genomic response in the cell A method of cellular evaluation based on the electronic nature of cells is reveled though cellular reproductions use of a magnetic force. The dynamic process of nuclear response is shown to be electronic in nature relative to DNA mediating electrons hydrogen bonding in bases pairing of DNA though out the ... 06/15/06 - 20060127878 - Hydrogel preparation and process of manufacture thereof A polymeric hydrogel having a network of a macropores and micropores formed by copolymerizing at least one monomer having at least one double bond and at least one crosslinker having at least two double bonds in the presence of an organic additive forming a hydro-organic system with water, and uses ... 06/15/06 - 20060127877 - Fluorescent protein (2) the molar absorption coefficient at 494 nm is 94600 M−1cm−1; (3) the quantum yield is 0.65; and (4) the pH sensitivity of the fluorescent property is low in the range between pH 4 and pH 11. ... 06/08/06 - 20060121446 - Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms. ... 06/08/06 - 20060121445 - Scoring method for determining pancreas suitability for islet isolation The invention relates to a method for evaluating a pancreas as a source of therapeutically useful islets. A scoring system is set forth whereby 5 criteria are listed. If three criteria are positive, then the pancreas is a suitable source of therapeutically useful islets. ... 06/08/06 - 20060121444 - Use of flow-cytrometric analysis to optimize cell banking strategies for cho cells Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with regard to the desire to establish production processes that are completely devoid of serum ... 06/08/06 - 20060121443 - Determination of cell viability This invention provides methods and compositions for determining cell viability by use of a reagent that is detectable in viable, or living, cells even after they have been fixed. The invention may be advantageously used with a sample of cells destined for transplantation or with cells to be used in ... 06/08/06 - 20060121442 - Method for dosing a biological or chemical sample producing an image including the image of the beam (18) diffused by the sample (10), analysing the image according to reference criteria, extracting information specific to the light/sample beam interaction, calculating the assay. ... 06/08/06 - 20060121441 - Methods of determining the effect of an agent on diploid cells and/or on the pattern of expression of polypeptides expressed therewith A method of determining the effect of an agent on a diploid cell and/or on an expression or activity of a polypeptide expressed within the diploid cell is provided. The method is effected by: (a) administering an exogenous RNA molecule encoding the polypeptide into the diploid cell; (b) contacting the ... 06/01/06 - 20060115805 - Gelatine-based materials as swabs A swab comprising gelatine or collagen has been found to have a remarkably high recovery of microorganisms. Furthermore, the samples, such as microorganisms, spores, nucleotides and other biologically or biochemically relevant compounds can be fully recovered from the collagen- or gelatine-comprising swab. The invention thus provides a method and swab ... 06/01/06 - 20060115804 - Method of studying living cells The present invention provides a method of eliciting a Raman signal from a living cell, or a plurality of living cells, said method comprising irradiating the cell with a laser having a wavelength of 785±60 nm. ... 05/25/06 - 20060110722 - Cell mimic platform and method A platform and method for mimicking the environment within a cell is provided. The platform includes a microfluidic device defining a chamber. At least one hydrogel post is positioned within the chamber of the microfluidic device. Each hydrogel post defines a corresponding pore for receiving a first molecule therein. Second ... 05/18/06 - 20060105322 - Intracellular metabolic flux analysis method using substrate labeled with isotope A method for analyzing an intracellular metabolic flux comprising determining the intracellular metabolic flux from analytical values of cells cultured in a medium containing an isotope-labeled substrate as a carbon source on the basis of an intracellular metabolic flux model constructed for the intracellular metabolic flux to be analyzed, wherein ... 05/18/06 - 20060105321 - Methods for evaluating cell membrane properties Methods for measuring cell membrane property are disclosed. A computer readable medium includes instructions for deriving from transcellular impedance a measurement of a cell membrane property and provides the stability and error of the measurement. The derivation from the transcellular impedance includes the real and imaginary components of the transcellular ... 05/18/06 - 20060105320 - Electrical conductors and devices from prion-like proteins The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing. ... 05/18/06 - 20060105319 - Method for converting venous blood values to arterial blood values, system for utilising said method and devices for such system The invention relates to methods of converting venous blood values to arterial blood values. This has the advantage that arterial blood samples need not be taken, and the disadvantages compared to venous blood samples when taking arterial blood samples are eliminated. The method is basically based on three steps, namely ... 05/18/06 - 20060105318 - Compositions and methods for non-targeted activation of endogenous genes The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment ... 05/11/06 - 20060099571 - Stabilized bioactive peptides and methods of identification, synthesis, and use An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group ... 05/11/06 - 20060099570 - Device and method for non-invasive measurement of the individual metabolic rate of a substantially spherical metabolizing particle The present invention relates to methods and devices for non-invasive and non-disturbing measurements of metabolizing rates of substantially spherical metabolizing particles, such as an embryo, and to a method and device for controlling oxygen partial pressure at the level of the embryo. Furthermore, the invention relates to a method for ... 05/11/06 - 20060099569 - Method and device for diagnosing oncological diseases The invention relates to medicine and can be used for diagnosing oncological diseases, manly on early stages thereof and for evaluating a treatment efficiency. The inventive method consists in studying an aqueous solution of native plasma or a native blood serum of a patient with the aid of a laser ... 05/11/06 - 20060099568 - Signals and molecular species involved in senescence The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the ... 05/04/06 - 20060094003 - Acetylcholine-dependent current as a novel ionic target for atrial fibrillation A method for treating a cardiac pathology. The method includes the administration to a mammal of a therapeutically effective amount of a substance interfering with an acetylcholine-dependent potassium current. Also, a method for identifying a compound for treating atrial fibrillation in a mammal. ... 05/04/06 - 20060094002 - Eukaryotic biosensor making use of a calcium regulated light emitting enzyme The present invention provides a method of using eukaryotic cells being transformed with a light emitting Ca2+ regulated photoprotein gene for determining the presence or absence of at least one toxic substance in a sample and for assisting in the identification of the toxicant(s). More specifically there is provided a ... 05/04/06 - 20060094001 - Method and device for image processing and learning with neuronal cultures It is disclosed a device for image processing and learning comprising at least a “multi electrode array” (MEA), over which an homogeneous culture of interconnected neurons, so that forming a cell network, is grown on, wherein said MEA is able to stimulate and record the electric activity of said neurons. ... 05/04/06 - 20060094000 - Destructible surfactants and uses thereof Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group that enable degradation of the surfactant under acidic conditions. The invention also includes methods of using anionic surfactants in a variety of applications relating to samples containing small molecules. ... 04/27/06 - 20060088817 - Method of determining plant species with pyrolysis-gas chromatography A method of identifying a plant species includes the steps of: preparing a fragment of the plant; heating the fragment to obtain lignin from the fragment; gasifying the lignin at a high temperature to obtain components of the lignin; obtaining a flux profile of the components; and determining the species ... 04/27/06 - 20060088816 - Detection of transmembrane potentials using n,n,n'-trialkyl thiobarbituric acid-derived polymethine oxonols wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl and heteroalkyl; n is an integer from 1 to 3; Z is Na, K, ammonium or other biologically acceptable salt. ... 04/27/06 - 20060088815 - Method for evaluation of endocrine disruptive action There is provided a method for a quick and easy evaluation of a substance which is an object of evaluation for its endocrine disruptive action. An evaluating method according to the present invention is a method for the evaluation of endocrine disruptive action which is characterized in comprising a step ... 04/20/06 - 20060084051 - Grid etcher An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and placing intersecting channels across the extracellular matrix components by removing the extracellular matrix components ... 04/13/06 - 20060078877 - Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location ... 04/13/06 - 20060078876 - Methods of determining deficiencies in intracellular levels of cysteine and glutathione The present invention provides cell culture media and methods useful for determining levels of intracellular function of glutathione or cysteine and for providing biochemical analysis of antioxidant function in human lymphocytes. ... 04/13/06 - 20060078875 - Genetic selection of small molecule modulators of protein-protein interactions The present invention provides a method of production and screening of small molecule modulation of inter-macromolecule interaction. The method involves providing a living cell containing a gene that directs expression of a gene product to be assayed for the ability to modulate inter-macromolecule interactions and an inter-macromolecule interaction whose interaction ... 04/13/06 - 20060078874 - Use of nuclear hormone receptors The present invention presents the means to identify agonists and antagonists of the NR/ligand interaction by using NRs. The term “NR” refers to any proteins either derived from a naturally occurring NR (from any species), or which shares significant structural and functional characteristics peculiar to a naturally occurring NR. Such ... 04/13/06 - 20060078873 - Blood analysis device and blood analysis method A blood analysis device for centrifugally separating plasma in a channel, wherein conveyance of blood, plasma and calibration liquid is effected within the device without using a pump or the like. The calibrator solution is reliably discharged from a sensor portion so as to make high precision analysis possible. A ... 04/06/06 - 20060073473 - Cytotoxic assay and new established cell line of sturgeon origin An object of the present invention is to provide a cytotoxic assay using a new established fish cell line. The invention attained according to the object is a cytotoxic assay, wherein an evaluation of toxicity of a specimen is performed on the basis of its toxicity to an established cell ... 04/06/06 - 20060073472 - Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death A novel class of pyridazine compositions and related methods of use. ... 04/06/06 - 20060073471 - Method of using molecularly imprinted polymers for noninvasive diagnosis The invention outlines a method for using Molecularly Imprinted Polymers (MIP's) in conjunction with specific, narrow wavelength light sources to non-invasively test for disease precursors. The invention makes it possible for a real time analysis to be carried out on the human body with minimal effort and greater efficiency than ... 04/06/06 - 20060073470 - Method of counting microorganisms or cells A method of counting microorganisms or cells in a sample by labeling the microorganisms or cells with a fluorescent labeling reagent, which comprises contacting the sample containing the microorganisms or cells with an adhesive sheet having an adhesive layer laminated on at least one surface of a substrate to capture ... 04/06/06 - 20060073469 - Methods and compositions for monitoring cell migration and identifying clinically relevant cytotoxic t lymphocyte activity A three-dimensional reconstruct model containing solid layers of collagen and fibroblasts closely mimic the condition of patients in vivo, preserving in vivo phenotypic and functional characteristics of the cells. Reconstructs can be used to detect cellular migration, including active migration of cytotoxic T lymphocytes towards tumor cells, which can be ... 04/06/06 - 20060073468 - Genetically modified cyclic-nucleotide controlled ion channels and the use thereof The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits have been altered so as to have higher sensitivity to cAMP and/or higher selectivity for cAMP compared to cGMP in comparison with the wild type according to SEQ ID NO 1 and 2. ... 03/30/06 - 20060068377 - Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location ... 03/30/06 - 20060068376 - Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location ... 03/30/06 - 20060068375 - Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location ... 03/30/06 - 20060068374 - Cell motility assay An electrooptical method is disclosed for quantifying the motility response of cells to external stimuli, wherein a target cell population (formed as a function of said response) is subsequently optically differentiated by the addition of an optical differentiation solution, and whereby the targeted cell population becomes more or less detectable ... 03/30/06 - 20060068373 - Systems and methods of identifying biomarkers for subsequent screening and monitoring of diseases A system for generating an image of ultrastructural biomarkers from a biological sample is provided. The system includes a grid onto which a sample to be imaged may be placed and a cryogenic reservoir into which the grid and sample may be immersed for vitrification of the sample. The system ... 03/30/06 - 20060068372 - Method of classifying plant embryos using penalized logistic regression A method is disclosed for classifying plant embryos according to their quality using a penalized logistic regression (PLR) model. First, sets of image or spectral data are acquired from plant embryos of known quality, respectively. Second, each of the acquired sets of image or spectral data is associated with one ... 03/30/06 - 20060068371 - Methods for analyzing inter-cellular phenomena Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological ... 03/30/06 - 20060068370 - Liver specific chimeric regulatory sequence and use thereof The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer of 5′ flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific cell lineages, such as liver cells, ... 03/23/06 - 20060063145 - Mass spectrometric differentiation of tissue states The invention relates to the determination and visualization of the spatial distribution of tissue states in histologic tissue sections on the basis of mass spectrometric signals acquired so as to be spatially resolved. The invention provides a method which determines the tissue state for the tissue spots as a state ... 03/23/06 - 20060063144 - Methods for identifying stem cells based on nuclear morphotypes Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing ... 03/23/06 - 20060063143 - Immortalized hypothalamic neuronal cell lines The present invention is directed to a method of preparing cell lines of hypothalamic origin. The method involves infecting fetal hypothalamic cells with a retroviral vector harbouring a viral oncogene, preferably SV-40 large T antigen, followed by selection and cloning. A plurality of cell lines have been prepared which express ... 03/16/06 - 20060057560 - System and method for denaturing and fixing collagenous tissue A method for modifying a geometry of a collagenous tissue mass includes heating the collagenous tissue mass to a temperature sufficient to cause denaturation, and introducing a biocompatible fixative, such as genepin, into the collagenous tissue mass. ... 03/16/06 - 20060057559 - High-throughput cell migration screening assay The invention relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate cell activation or migration, e.g., lymphocyte migration, via modulation of the expression and/or activity of migration molecules such as, for example, ... 03/16/06 - 20060057558 - Method to measure the effect of topically applied agents using skin maintained in organ culture The method employs a piece of skin of area greater than 1 cm2 cultured under conditions that maintain its viability and substantially normal structure for sufficient time for topically applied test material to potentially exert an effect. The skin includes the majority of the epidermal layer plus an appropriate amount ... 03/16/06 - 20060057557 - Method for identifying an image of a well in an image of a well-bearing component A method for identifying images of wells in an image of a well-bearing object such as multiwell plates or picowell carriers is provided. An observation component, such as a camera, is used to approach focus of a focal point of a well-bottom. An image of the focal point is acquired. ... 03/16/06 - 20060057556 - Contiguous capillary electrospray sources and analytical devices Contiguous capillaries useful for separating and electrospraying a fluid comprising analyte and electrolyte are provided. The contiguous capillaries have spray tips at one end of the capillaries and electrically conductive portions in proximity to the spray tips. Methods for making the contiguous capillaries and their use as electrospray sources are ... 03/16/06 - 20060057555 - Method and system for controlling the development of biological entities A method and system are presented for use in controlling the processing of components, e.g. biological entities. Each component is assigned with a unique machine readable identification mark. Data records are provided representative of matching sets of the identification marks relating to at least two associated components. Each component-containing holder ... 03/16/06 - 20060057554 - Sample collecting device and mass spectrometry of device A sample collection device comprising a support bearing an inert absorbing matrix for a fluid sample is described. The device may or may not have a lancet. Also described for a sample device is a method of using a mass spectrometer in a laboratory where the sample in its matrix ... 03/16/06 - 20060057553 - Chimeric viral vectors for gene therapy The invention relates to a single nucleic acid vector comprising both adenoviral and retroviral sequences for gene therapy. The vectors described herein (See FIG. 2) are capable of transducing all cis and trans components of a retroviral vector for the generation of high titer recombinant retroviral vectors. The chimeric vectors ... 03/09/06 - 20060051738 - Dual glucose-turbidimetric analytical sensors Diagnostic dry reagent tests capable of reacting with a single drop of whole blood and reporting both glucose and light-scattering analytes, such as chylomicrons, are taught. Such dry reagent tests may employ electrochemical detection methodologies, optical detection methodologies, or both methodologies. These tests alert diabetics to excessive levels of postprandial ... 03/09/06 - 20060051737 - Nucleic and amino acid sequences of human rif1 and methods of use thereof The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various ... 03/09/06 - 20060051736 - Paraffin-control marker A sample configured to be cut to form a set of serial sections. The sample includes a sample block; at least one tissue sample substantially embedded in the sample block; and a least one control-marker core substantially embedded in the sample block and having a select shape as viewed from ... 03/09/06 - 20060051735 - Method and devices for transferring biological cells between a carrier and a probe A cell transfer method is described, in which transfer of at least one biological cell (21) describing a natural cell locomotion between a carrier (80) and a probe (10) is provided, and whereby positioning the probe (10) and the carrier (80) relative to one another in a transfer arrangement is ... 03/09/06 - 20060051734 - Apparatus for mapping biological tissue quality The present invention provides an apparatus suitable for use in investigating multi-phase biological tissue histology, which apparatus comprises a trans-ductally deployable probe mounting a periodically displaceable body of at least one tactile sensing device, said periodically displaceable body having an excitation frequency bandwidth in the range of from 1 Hz ... 03/09/06 - 20060051733 - Monitoring of cells A method for monitoring cells in a microfluidic-device, wherein the device includes a chamber comprising a sensor, and the monitoring is under conditions such that attachment of cells to the surface of the chamber is inhibited. ... 03/02/06 - 20060046245 - Porous device A porous device for use in a method of synthesis comprising a body having an internal region which is porous wherein an active material, for example a solid support resin, is entrapped within the internal region. ... 03/02/06 - 20060046244 - Automated seed sampler and methods of sampling, testing and bulking seeds An automated seed sampler includes a sampling station; a sampler for removing material from a seed in the sampling station; a seed conveyer for conveying the seed from the sampling station to a compartment in a seed tray; and a conveyor for conveying the material removed from the seed to ... 02/23/06 - 20060040256 - Determination of testosterone by mass spectrometry Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present ... 02/23/06 - 20060040255 - Cell line designated kt-1 established from tongue epithelial and use thereof A cell line KT-1 isolated from mouse tongue epithelium using high-level expression of integrin β1 as the indicator and established by a long time culture, and which expresses a taste receptor; a taste sensor comprising the cell line KT-1; the use of the cell line KT-1 to search for a ... 02/23/06 - 20060040254 - Method for identifying bronchoconstriction relaxing substances In a method of measuring a relaxing effect on constricted human bronchi of a candidate substance a bronchus tissue preparation is mounted to a force transducer in a test apparatus. After conditioning the preparation is exposed for a contraction-effective dose of a known contraction-effective substance to make it assume a ... 02/23/06 - 20060040253 - Use of smad3 inhibitor in the treatment of fibrosis dependent on epithelial to mesenchymal transition as in the eye and kidney The invention is related to inhibition of Smad3 to ameliorate Smad3 mediated epithelial to mesenchymal transition. ... 02/23/06 - 20060040252 - Prognostic tests for development of dermal stretch marks and implications for the preventive treatment thereof Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method of monitoring the aging process of the ... 02/23/06 - 20060040251 - Portable medical measurement device and method A portable medical measurement device and method are used for biomedical measurements. The medical measurement device comprises a medical measurement unit for analyzing the reaction of a measured target, a signal receiving unit for receiving a measurement signal, a lookup table for storing reference signals and corresponding parameters, and a ... 02/23/06 - 20060040250 - Systems for sensitive detection of g-protein coupled receptor and orphan receptor function using reporter enzyme mutant complementation Methods for detecting G-protein coupled receptor (GPCR) activity; methods for assaying GPCR activity; and methods for screening for GPCR ligands, G-protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process are described. Included are methods for expanding ICAST technologies for assaying GPCR activity with ... 02/23/06 - 20060040249 - Screening method involving transfected primary cells A screening assay for identifying an agent that modulates T cells. ... 02/16/06 - 20060035211 - Methods for identifying conditions affecting a cell state The present invention is directed to methods for identifying agents which affect cell state. The instant invention provides rapid and efficient methods for identifying agents which affect cell state. Methods are directed toward the screening of complex combinations of agents for their ability to affect cell state. In one embodiment, ... 02/16/06 - 20060035210 - Method of analyzing metabolism for plant, method of producing labeled plants, labeled plants, and method of measuring nmr for plants The present invention provides a method of analyzing metabolism of a plant in which measurement sensitivity for nuclides such as 13C and 15N having low natural abundance ratios is improved using NMR. A labeled plant uniformly labeled with a stable isotope is produced by providing the plant with a nutrition ... 02/16/06 - 20060035209 - Screening method The present invention provides a screening method for a prophylactic or therapeutic substance for a disease associated with a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence shown by SEQ ID NO:2 or a salt thereof, for example, a renal disease or ... 02/16/06 - 20060035208 - Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip. This aim, and also others, are achieved, in accordance with the invention, by means ... 02/09/06 - 20060029927 - Method for quantitative analysis of blood vessel structure We disclose quantitative geometrical analysis enabling the measurement of several features of images of tissues including perimeter, area, and other metrics. Automation of feature extraction creates a high throughput capability that enables analysis of serial sections for more accurate measurement of tissue dimensions. Measurement results are input into a relational ... 02/09/06 - 20060029926 - Blocking compositions for immunoassays Compositions and processes for qualitative or quantitative one-step, two-site, tag/anti-tag or competitive non-bibulous lateral flow (immunochromatographic) assays for analytes in body fluids including chemically modified proteins as blocking and/or dispersing agents in conjunction with additives eliminating non-specific interference with the detection agents and/or binding partner caused by endogenous polypeptide constituents. ... 02/09/06 - 20060029925 - Solid bio-material for a sensor that detects bio-electric signals through the use of the characteristics and functions of bio-epidermal tissues and epidermal tissues of living organisms and the methods for producing the same The present invention discloses a solid bio-material for the detection of a bio-electromagnetic signal, which senses an information signal generated from living organisms and changes thereof by using fish scale, feathers of fowl and carapaces of tortoises among epidermal tissues of animals having the function of detecting, memorizing and transferring ... 02/09/06 - 20060029924 - Assay device for liquid sample Disclosed is an assay device comprising liquid transport means adapted to take up a liquid sample and conduct the liquid to an analyte detection region operable to provide a test signal indicative of the presence and/or amount of an analyte in the liquid sample; the assay device further comprising a ... 02/02/06 - 20060024665 - Prmts as modifiers of the p53 pathway and methods of use Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided. ... 02/02/06 - 20060024664 - Methods and products related to evaluating the quality of a polysaccharide The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described. ... 02/02/06 - 20060024663 - Methods for determining the potency, specificity, and toxicity of microsomal prostaglandin e2 synthase Methods of determining the potency, specificity, and toxicity of microsomal prostaglandin E2 synthase inhibitors are provided that utilize one cell-based assay system. ... 02/02/06 - 20060024662 - Methods for magnetic resonance imaging In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are generated in situ via genetic instructions and become potent upon sequestering available metal atoms. Exemplary contrast agents include metal-binding proteins. ... 02/02/06 - 20060024661 - Modulation of crf potentiation of nmda receptor currents via crf receptor 2 This invention pertains to the discovery that CRF increases NMDAR (N-methyl-D-aspartate receptor)-mediated currents at excitatory synapses onto a subset of dopamine cells in the ventral tegmental area (VTA) in the mammalian brain. This effect is not blocked by a CRF receptor 1 (CRF-R1) antagonist, but is blocked by a CRF ... 02/02/06 - 20060024660 - Method for relative quantification of proteins The invention relates to a method for comparative analysis of two or more samples to determine ratios of the amounts of proteins of the samples, which method comprises labeling lysine residues of the proteins, separating the labeled proteins by 2D gel electrophoresis, before cleavage and mass spectrometry analysis. ... 02/02/06 - 20060024659 - Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. ... 02/02/06 - 20060024658 - Composition and methods for evaluating an organism's response to alcohol or stimulants This invention pertains to the identification of genes whose expression levels are altered by chronic exposure of a cell, tissue, or organism to one or more drugs of abuse (e.g. alcohol, stimulants, opiates, etc.). In one embodiment, this invention provides a method of monitoring the response of a cell a ... 01/26/06 - 20060019237 - In vitro wound healing assay and device Devices for creating model wounds in vitro are provided, along with kits and systems including the devices. Methods for making such devices and for modeling wounds are also provided. ... 01/26/06 - 20060019236 - Membrane fusion assay The present invention relates to an assay for detecting membrane fusion. More particularly the present invention relates to assays for detecting exocytosis and/or endocytosis wherein membrane fusion is detected by an increase in fluorescence of a lipophilic fluorescent dye due to fluorescence resonance energy transfer (FRET) occurring from one lipophilic ... 01/26/06 - 20060019235 - Molecular and functional profiling using a cellular microarray Cells are profiled with respect to their expression of cell surface molecules, and ability to respond to external stimulus in the microenvironment. External stimuli include cell-cell interactions, response to factors, and the like. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused ... 01/19/06 - 20060014137 - System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect neurite outgrowth. ... 01/19/06 - 20060014136 - Method of screening for protection from microbial infection Screening assays that allow for the identification of agents that modulate host cell response to microbial infection. The methods of the invention provide the ability to measure the reduction in toxicity to the host cell, which is directly related to the ability of a compound to alter the cell's responses ... 01/19/06 - 20060014135 - Assay for distinguishing live and dead cells Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is ... 01/12/06 - 20060008796 - Methods for screening cellular proliferation using isotope labels The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis. In particular, the methods utilize non-radioactive stable isotope labels to endogenously label DNA synthesized through the de novo nucleotide synthesis pathway in a cell. The amount of label incorporated ... 01/12/06 - 20060008795 - Method and an apparatus for determining well or fully differentiated mammal cells The invention relates to a method for the in-vitro determination, especially typification, of well or fully differentiated mammal cells comprising the steps of: a) irradiating the cells with infrared light and recording the absorption spectrum obtained; b) carrying out a Fourier transformation of the absorption spectrum from (a) to obtain ... 01/12/06 - 20060008794 - Hox code functions as a growth synchronizing moving reference frame The determination of position during metazoan growth appears complex, in part, because we observe that growth does not occur at a constant rate, as temperatures fluctuate, so do the growth rates. One positioning method, a moving reference frame (MRF), is used in engineering, and navigation, to assign positions when velocity ... 01/12/06 - 20060008793 - Protein chips detecting system which can simultaneously detect multi target The present invention provides a protein chips detecting system which can simultaneously detect multi target, and the method for manufacturing the system. The invention increases the stability and sensitivity of the system by improving the present protein chips system and the manufacture. ... 01/05/06 - 20060003313 - Methods for identifying factors for differentiating definitive endoderm Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube. ... 01/05/06 - 20060003312 - Circulating stem cells and uses related thereto The disclosure provides, inter alia, methods for enhancing the contribution of circulating stem cells to a target tissue. Such methods may be useful for treating a variety of disorders. In a preferred embodiments, circulating stem cell contribution is enhanced by causing damage to the target tissue, or by administering an ... 01/05/06 - 20060003311 - In vitro screening of cellular events using 3d cell culture systems The present invention relates to in vitro cell culture conditions wherein transfected cells containing promoter-reporter constructs are cultivated in a 3D tissue-like environment. The referred 3D culture conditions may eventually implement appropriate biomaterial or scaffolds. ... 01/05/06 - 20060003310 - Device for performing cell assays A device for performing cell assays has at least one assay site. The site comprises a pair of stimulating electrodes and a cell confinement cavity for confining at least one cell in an extracellular fluid medium. The cell confinement cavity and the stimulating electrodes are arranged so that, in use, ... 12/29/05 - 20050287520 - Screening method and device, and new drug screening method and device The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of ... 12/29/05 - 20050287519 - Methods, compositions and compound assays for inhibiting amyloid-beta protein production A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a KINASE polypeptide, or fragment thereof, and measuring a compound-KINASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including phosphorylated kinase substrate and/or amyloid ... 12/29/05 - 20050287518 - Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes ... 12/29/05 - 20050287517 - T1r hetero-oligomeric taste receptor Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are ... 12/22/05 - 20050282152 - Drug testing with bio-artificial organ slices including for example those derived from liver A drug testing system using any number of bio-artificial organs, for example liver-slices based in a culture apparatus. The apparatus has a chamber with plasma and gas valves, animal organ slices being positioned securely in the chamber so as to maximize the surface area of organ slices exposed to the ... 12/22/05 - 20050282151 - Method and apparatus for sorting particles with a mems device A micromechanical particle sorting chip uses laser light directed through at least one of a reflective and refractive surface to come to a focus in an optically transparent layer. The laser light impinges on a particle of interest, causing it to fluoresce. Upon detecting the fluorescence, a micromemchanical actuator is ... 12/22/05 - 20050282150 - Antibodies to cyclin e2 protein Disclosed are nucleic acid molecules encoding novel cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules. ... 12/22/05 - 20050282149 - Closed-loop electrical stimulation system for cell cultures The present invention provides a sensitive system for measuring the physiological response of an in-vitro cell culture to an environmental parameter. An electrical property of the cell culture is measured as a control signal, and a parameter of a stimulus is adjusted in real time to maintain the control signal ... 12/22/05 - 20050282148 - Artificial immune system: methods for making and use The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates ... 12/22/05 - 20050282147 - Methods for assaying gene imprinting and methylated cpg islands Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for ... 12/22/05 - 20050282146 - Methods to predict additional nodal metastases in breast cancer patients A method and system to predict the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy. ... 12/22/05 - 20050282145 - Method for identifying anti-neoplastic compounds Aspects of the present invention relate to methods of evaluating substances for their effects on cellular proliferation. Particular aspects of the invention use cultures of cells containing more than one type of cell. ... 12/15/05 - 20050277111 - Measuring method using surface acoustic wave device, and surface acoustic wave device and biosensor device A measuring method using a surface acoustic wave device, with which even in a case where a target substance having a different viscosity is added to a buffer liquid on the surface acoustic wave device it is possible to measure a mass load accurately without suffering an effect of this ... 12/15/05 - 20050277110 - Method of measuring the activity of g(alpha)i- or g(alpha)o-coupled receptors using ca2+ influx in cells A method of measuring the activation or deactivation of G(alpha)i- or G(alpha)o-coupled receptors, and methods of identifying agonists or antagonists of such receptors. ... 12/15/05 - 20050277109 - Predictive assay for immune response The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) ... 12/08/05 - 20050272028 - Myostatin and mimetics thereof An isolated mimetic of functional myostatin comprising part of the amino acid sequence of functional myostatin, such that the mimetic is capable of inhibiting muscle growth. ... 12/08/05 - 20050272027 - Real-time clinical diagnostic systems for fluorescent spectrum analysis of tissue cells and methods thereof Real-time clinical diagnostic expert systems for fluorescent spectrum analysis of tissue cells and methods thereof. An exemplary system includes a set of optical fibers, wherein the first optical fiber introduces an incident light to an subject epidermal tissue, and the second optical fiber receives an auto-fluorescent signal, a set of ... 12/08/05 - 20050272026 - Apparatus and method for cell analysis A cell analysis apparatus is described that includes a test sample preparation part for preparing a test sample by treating an analyte with a dye for staining an intracellular substance of the cells in the analyte, a detector for detecting scattered light and fluorescence from each cell in the test ... 12/08/05 - 20050272025 - Method of detecting and preventing alzheimer's disease, particularly at prodromal and early stages A method of detecting Alzheimer's disease includes detecting a disruption or alteration in normal sub-cellular distribution of G-protein receptor kinases (GRKs), particularly GRK2 and GRK5. The disruption is caused by abnormal accumulation of soluble β-amyloid. The prevention or suppression of the disease progression at prodromal or early stages includes correction ... 12/01/05 - 20050266396 - Dielectric relaxation spectroscopy apparatus and methods of use Methods and apparatus for measuring the dielectric relaxation properties of a sample are disclosed. Methods are disclosed for amplifying or controlling the dielectric relaxation properties of a sample by adding particles, such as functionally coated particles. In certain methods, the particles amplify or control the dielectric relaxation properties of the ... 12/01/05 - 20050266395 - Method and system for morphology based mitosis identification and classification of digital images A method and system for morphology based mitosis identification and classification of digital images. Luminance parameters such as intensity, etc. from a digital image of a biological sample (e.g., tissue cells) to which a chemical compound (e.g., a marker dye) has been applied are analyzed and corrected if necessary. Morphological ... 12/01/05 - 20050266394 - Magnetophoretic cell clarification One aspect of the present invention relates to magnetophoretic devices for cell clarification. In one embodiment, the magnetophoretic device is a counter-current device, comprising a plurality of pairs of magnets selected from the group consisting of permanent magnets and electromagnets; a chain rotated by a motor; tubing; a feed inlet; ... 12/01/05 - 20050266393 - Circulating flow device for assays of cell cultures, cellular components and cell products In vitro culture devices and methods are described. The subject methods and devices provide a means whereby cells and/or subcellular material are grown or held in a culture device that maintains the cells and/or subcellular material in a physiologically representative environment, thereby improving the predictive value of toxicity and metabolism ... 11/24/05 - 20050260558 - Comparative phenotype analysis of cells including testing of biologically active chemicals The present invention relates to growing and testing any cell type in a multitest format. The present invention is suited for the characterization of microorganisms, as well as animal and plant cells. The present invention is also particularly suited for analysis of phenotypic differences between strains of organisms, including cultures ... 11/24/05 - 20050260557 - Method of quantifying the cell-binding properties of a medical device The invention provides a method for quantifying the cell-binding properties of a medical device. In practicing the method, a medical device having at least one type of binding agent is incubated with cells expressing a ligand having an affinity for the binding agent on the medical device. The cells that ... 11/24/05 - 20050260556 - Novel ubiquitin ligases as therapeutic targets The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, ... 11/24/05 - 20050260555 - Chemosensitivity measurement using caspase activity A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the apoptosis is determined from the accumulated caspase activity of a sample comprising cells and a medium by adding said at least one substance to ... 11/17/05 - 20050255453 - Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample Multilayer reagent test strips for quantitating glycated protein in a fluid sample, as well as methods for using the same, are provided. The subject multilayer test strips include at least a filter layer, a proteinase layer and a ketoamine oxidase signal producing and fluid flow control system layer. In using ... 11/17/05 - 20050255452 - Mapping molecular interactions in plants with protein fragments complementation assays The present invention describes a method of expressing PCA interacting partners in plant material comprising: (A) transforming said material with: (1) a first construct coding for a first fusion product comprising (a) a first fragment of a first molecule whose fragments can exhibit a detectable activity when associated and (b) ... 11/17/05 - 20050255451 - Toll-like receptor 9 modulators TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of ... 11/17/05 - 20050255450 - Methods of identifying lead compounds that modulate toxicity of neurotoxic polypeptides Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's ... 11/17/05 - 20050255449 - Targeted fusion proteins and methods for the characterization of cellular membrane domains Cell membranes containing glycolipid-enriched membrane (GEM) and non-glycolipid-enriched membrane (non-GEM) domains are targeted using fusion proteins that are anchored in the cell membrane. Fusion proteins to target GEM (or non-GEM) domains are comprised of a selected fluorescent polypeptide, a membrane-targeting sequence of p56Lck (or pp60c-Src for non-GEM domains) and a ... 11/17/05 - 20050255448 - System for amplifying optical detection of cantilever deflection A sensor system configured to amplify cantilever deflection, having: a reflective membrane connected to a cantilever, wherein the reflective membrane rotates more than the cantilever when the cantilever deflects. A sensor system, including: a cantilever having a first end and a second end, the first end being held at a ... 11/17/05 - 20050255447 - Hematology reference control containing an immature granulocyte component A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of ... 11/17/05 - 20050255446 - Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration A system and method for high throughput patch clamp measurements to study the effect of various chemicals on ion transfer channels is provided. One or more patch clamp configurations is established, each comprising a cell sealed to a pipette. The pipettes are affixed to a pipette fixture. The pipette fixture ... 11/17/05 - 20050255445 - Method for high throughput cell-based assays using versatile living microarrays The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules ... 11/17/05 - 20050255444 - Method for detecting arcenic iions with iindicator bacteria The invention is concerned with a biologically based test system for the detection of inorganic and organic pollutants in water samples. In particular, the present invention is concerned with the development of a strategy for the control of background expression of biosensors in said biologically based test system. Furthermore, the ... 11/17/05 - 20050255443 - Method of screening cell growth inhibitor and cell growth inhibitor The present invention provides a method for screening a cytostatic agent characterized by determining an effect of inhibiting intracellular signaling mediated by a remaining fragment of a cell membrane-anchored growth factor, and the cytostatic agent. In growth factors of the EGF family, the physiological significance of the remaining fragment is ... 11/10/05 - 20050250091 - Raman molecular imaging for detection of bladder cancer Raman molecular imaging is used to differentiate between normal tissue and benign and malignant lesions of bladder and other tissues, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the cancerous state of cells ... 11/10/05 - 20050250090 - Assay systems and methods for detecting molecules that interact with sk2 channels The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that ... 11/10/05 - 20050250089 - Biological soil detector and method of using same A biological soil detector and a method for detecting bio soil are provided. The biological soil detector comprises: A solid support member; a specific indicator immobilized on the solid support member, the specific indicator comprising a material sensitive to the presence of blood; and the solid support and specific indicator ... 11/03/05 - 20050244812 - Kits and methods for detection of apoptotic cells The present invention provides kits and in vitro, in vivo or ex vivo detection methods by using compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their cell membranes, such as cells undergoing apoptosis, while binding to a lesser degree to normal cells. ... 11/03/05 - 20050244811 - Matrix array nanobiosensor An apparatus for detecting multiple analytes comprising an array of nanobiosensors, each comprising a biological entity immobilized onto carbon nanotubes, wherein a plurality of the nanobiosensors in the array have unique biological entities, wherein a first one of the plurality of nanobiosensors has a first biological entity immobilized onto carbon ... 11/03/05 - 20050244810 - Taste signaling in gastrointestinal cells Disclosed are materials and methods relevant to taste transduction. Also disclosed are human gastrointestinal cells that comprise or are capable expressing endogenous taste signaling proteins. Also disclosed are human gastrointestinal cells that comprise or are capable of expressing endogenous taste signaling proteins as well as hormones, neurotransmitters or soluble mediators ... 11/03/05 - 20050244809 - Array biosensor and method of using same for detecting the concentration of one or more analytes in one or more biological samples A device for detections of one or more analytes in one or more samples is disclosed. The device can simultaneously detect multiple analytes in a sample or an analyte in a plurality of samples. The device has a plurality of wells formed thereon. Each of the well has a respective ... 11/03/05 - 20050244808 - Screening methods using zebrafish to identify thrombotic and anti-thrombotic compounds and genes Disclosed are improved methods using zebrafish to identifying anti-thrombotic substances for use in therapy and to identify genes associated with all aspects of thrombus formation, including those associated with an increased risk of thrombosis in humans. The preferred screening assays described include laser irradiation injury, sodium hydroxide-induced gill bleeding and ... 11/03/05 - 20050244807 - Two-photon absorption heteroaromatic chromophores and compositions thereof The present invention relates to new heteroaromatic compounds with high two-photon absorption activity, useful in particular as optical power limiting agents via two-photon absorption or as imaging agents in confocal laser scanning fluorescence microsopy via two-photon absorption or excitation. ... 11/03/05 - 20050244806 - Mutant proteins and use thereof for the manufacture of medicaments and the treatment of humans or animals suffering from conformational diseases The invention relates to a mutant prion protein (PrP), the globular domain of which comprises an engineered second disulfide bond in a similar position as in the human doppel protein (hDpl). In an embodiment, the prion protein has an engineered extra disulfide bond in the presumed ‘factor X’ binding epitope ... 10/27/05 - 20050239051 - Use of isogenic human cancer cells for high-throughput screening and drug discovery A strategy for drug-screening is based on cells that are isogenic except for a gene of interest. Each cell can be tranfected with a vector that encodes a different fluorescent protein that can be differentially detected to monitor cell growth. Co-culture of both cells allows facile screening for compounds with ... 10/27/05 - 20050239050 - Use of mdck cell line to predict corneal penetration of drugs A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ... 10/27/05 - 20050239049 - Method for the identification and/or validation of receptor tyrosine kinase inhibitors An in vivo method for the identification and/or validation of receptor tyrosine kinase inhibitors is described. Said method is characterised by the following steps: providing host cells comprising a nucleic acid construct encoding a peptide which comprises a tyrosine kinase domain of a receptor tyrosine kinase wherein said peptide lacks ... 10/27/05 - 20050239048 - Method and apparatus for enhancing biological photon receptors using plasmon resonance A method for enhancing the light detection capabilities of a chromophore. In one embodiment the method includes the steps of providing a plasmon resonant nanoparticle and placing the nanoparticle in close juxtaposition to the chromophore. In one embodiment the chromophore includes 11-cis-retinal and the nanoparticle is a metal such as ... 10/27/05 - 20050239047 - Methods and devices for determining a cell characteristic, and applications employing the same The present invention provides methods of determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, and biological state. The method generally involves detecting membrane movement in a cell to determine a characteristic of a cell. The methods of the invention are useful for ... 10/27/05 - 20050239046 - Method and apparatus for measuring changes in cell volume A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The current flow ... 10/27/05 - 20050239045 - Microorganism or cell collecting method, and microorganism or cell collecting implement used for the method A method capable of easily collecting microorganisms or cells in a short time without using a special device, comprising the steps of preparing a centrifugal tube (1) in which the inside thereof is divided into upper and lower parts by a filter (14) and water absorbing resin particles (15) are ... 10/27/05 - 20050239044 - Fluorescence technique for on-line monitoring of state of hydrogen-producing microorganisms In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H2 under sulfur depletion, comprising: a) providing sulfur-deprived algal culture; b) illuminating culture; c) measuring onset of H2 percentage in produced gas phase at multiple times to ascertain point immediately after anerobiosis to obtain H2 data ... 10/27/05 - 20050239043 - Subtilisin carlsberg proteins with reduced immunogenicity The present invention provides methods for the identification of CD4+ T-cell epitopes in subtilisin Carlsberg proteins. The present invention also provides for the production of altered peptides which, when incorporated into a wild-type subtilisin Carlsberg protein produce an altered immunogenic response, preferably a low immunogenic response in humans. In particular, ... 10/20/05 - 20050233309 - Kinetic process for the detection, diagnosis, processing, and monitoring of clonal cell populations A process for identifying the developmental history of a cell. In this process, a tissue sample is obtained from a living biological organism and, thereafter, is disaggregated to produce fragments whose maximum dimension is less than about 5 millimeters; the tissue sample is preferably disaggregated within about 10 minutes of ... 10/20/05 - 20050233308 - Method for modifying a property of a protein A property of a protein is modified by the following steps: (a) selecting 1000 or more genes from the genome of a first microorganism, and selecting 1000 or more genes from the genome of a second microorganism, wherein the genes from the first microorganism are orthologs to the genes from ... 10/20/05 - 20050233307 - Site-specific labeling of affinity tags in fusion proteins The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical ... 10/20/05 - 20050233306 - Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry The methods are useful in biology and medicine, including clinical ... 10/20/05 - 20050233305 - Sugar chain library constructed via cargo receptor gene modification The present invention relates to a method for modifying a carbohydrate moiety of a glycoprotein and a glycoprotein having a modified carbohydrate moiety. The present invention further relates to a cell expressing a glycoprotein with a modified carbohydrate moiety and a method for preparing the same. The present invention further ... 10/20/05 - 20050233304 - Method of screening remedy for renal failure A screening tool and a convenient screening method for obtaining a renal failure treating agent, and a pharmaceutical composition for treating renal failure and a production method thereof are disclosed. The aforementioned screening tool is a G protein coupling type receptor FGK which is a polypeptide capable of activating CTGF ... 10/20/05 - 20050233303 - Polymeric ammonium and or phosphonium salts having added ii-electrons and higher molecular weight as enhancers for chemiluminescent systems A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker with either a trisubstituted amine or trisubstituted phosphine. A fluorescent molecule may be attached to polymer along with the trisubstituted amine or ... 10/13/05 - 20050227222 - Pathogen identification method Methods and apparatuses for detecting, identifying, characterizing, and tracking pathogenic agents in any of a wide range of samples. ... 10/13/05 - 20050227221 - Methods and systems for evaluating and for comparing methods of testing tissue samples Using contextual response profiles to group genes into “equivalent” classes to infer biological functionality. Comparing such classes from different contexts (conditions) to identify genes that change functionality. Also, methods, systems and computer readable media to separate gene expression signatures and distinguish differential gene expression specific to pure tissue in a ... 10/13/05 - 20050227220 - Compositions and methods for evaluating and designing nuclear receptor ligands that modulate co-regulator affinity Isolated corepressor peptides derived from a nuclear receptor interacting motif of corepressor Nuclear Receptor Corepressor (NCoR) or Silencing Mediator of Retinoid and Thyroid receptors (SMRT) are provided which binds to nuclear receptor ligand binding domains. Methods of using these peptides to evaluating selectivity of a ligand for a nuclear receptor ... 10/06/05 - 20050221282 - High throughput screen The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. ... 10/06/05 - 20050221281 - Self-contained microfluidic biochip and apparatus A biochip and apparatus is disclosed for performing biological assays in a self-contained microfluidic platform. The disposable biochip for multi-step reactions comprises a body structure with a plurality of reagent cavities and reaction wells connected via microfluidic channels; the reagent cavities with reagent sealing means for storing a plurality of ... 10/06/05 - 20050221280 - Protein-protein interactions for pharmacological profiling The present invention provides methods for performing pharmacological profiling of a chemical compound, in particular to improve drug safety and efficacy at an early stage in the drug development process. The chemical compound may be a test compound, drug lead, known drug or toxicant. The compound is profiled against a ... 10/06/05 - 20050221279 - Method for creating chemical sensors using contact-based microdispensing technology Contact based rigid pin tool technology is utilized to print one or more indicator chemistries on an optical array or a disposable sheath configured on such arrays. Each indicator chemistry contains predetermined material, such as, light energy absorbing dye(s), optically responsive particles, etc., whose optical characteristics change in response to ... 10/06/05 - 20050221278 - Method for determining metabolic flux Sflux: Vector representing metabolic flux distribution to be determined, S(i): Vector selected for substance for which inputted value can be obtained, A(i): Adjustment vector, a, b: Coefficients for linear combination (b may be 0), p: Coefficient for obtaining consistency with input value as numerical value, q: Coefficient of adjustment vector. ... // - 1 - ... // - 1 - ... // - 1 - ... // - 1 - ... // - 1 - ... // - 4) performing linear combination for the selected vectors in accordance with the following equations to obtain a vector representing metabolic flux distribution: - ... 10/06/05 - 20050221277 - Intracorporeal substance measuring assembly An intracorporeal substance measuring assembly to be provided in an embedded-type substance sensor for detecting and measuring an intercorporeal analyte includes: a detection layer containing at least one fluorescent indicator for generating fluorescence according to the concentration of the analyte; and an optical separation layer which is provided on the ... 10/06/05 - 20050221276 - Sensor system A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detectable change when the probe is exposed to the ... 10/06/05 - 20050221275 - Hepatocyte free uptake assays The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits. ... 10/06/05 - 20050221274 - Multiwell plate assembly for use in high throughput assays A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can ... 10/06/05 - 20050221273 - Method for detecting diseases that are associated with defects of cystic fibrosis transmembrane conductance regulator (cftr)protein The invention concerns a method for the diagnosis of membrane channel defects in cells by comparing defective with non-defective cells with the following steps: influencing the volume regulation of the cells; recording the change of volume regulation resulting therefrom in non-defective cells; determining the existence of defective cells with a ... 10/06/05 - 20050221272 - Methods of identifying agents that mediate polypeptide aggregation The present invention is based, in part, on the discovery of methods for identifying compounds that mediate (by promoting or inhibiting) protein-protein interaction (e.g., aggregation, dimerization, or other physiologially significant association). Compounds that mediate such interaction, which are also within the scope of the invention, can be used to treat ... 10/06/05 - 20050221271 - Substrates, devices, and methods for cellular assays The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention ... 10/06/05 - 20050221270 - Process for identifying and treating cells types within a living organism A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated. ... 09/29/05 - 20050214742 - Screen for cdc7 inhibitors Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that encodes a mammalian Dbf4 protein. The yeast cell is dependent on the mammalian Cdc7 and Dbf4 proteins ... 09/29/05 - 20050214741 - Method for formulating and immobilizing a matrix protein and a matrix protein for use in a sensor A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein ... 09/29/05 - 20050214740 - Device for measuring extracellular potential and manufacturing method of the same A device for measuring extracellular potential includes a diaphragm and a detecting electrode. The diaphragm is formed on one surface thereof with a depression including at least one curved surface, and a hole is provided so as to penetrate from the curved surface of the depression through to the other ... 09/29/05 - 20050214739 - Expression of g protein coupled receptors in yeast Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protein-coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian Gα). The first and second heterologous DNA sequences are capable of expression in the ... 09/29/05 - 20050214738 - Conditional allele system A conditional allelic system is provided where recombinant cells express a fusion protein, where the fusion protein comprises at least a functional portion of a target protein and a destabilizing peptide. The destabilizing peptide binds to a small stabilizing molecule that results in the stabilization of the fusion protein in ... 09/29/05 - 20050214737 - Transparent filtered capillaries A microfluidic reactor (10) for trapping one or more particles of predetermined nominal size or range of sizes that have entered a flow inlet (12) includes a transparent reaction zone (14) which also serves as an in-situ detection zone wherein the detection zone is arranged so as substantially to correspond ... 09/29/05 - 20050214736 - Cell transporter for a biodevice A method of transporting cells comprising transporting a plurality of cells through a transport path of a biodevice and maintaining substantially free individual movement of each cell during the transporting of the cells through the transport path. ... 09/29/05 - 20050214735 - Method of visualizing proteins bound to protein-binding membranes A method of visualizing proteins bound to a protein-binding membrane is provided herein, comprising reacting proteins bound to protein-binding membranes with a compound of formula (I) wherein Ra, R1, R2, R3, R4, M, n, and m are as defined herein. ... 09/29/05 - 20050214734 - Cell population provided with identification codes and method of screening cell population The invention of this application provides a cell population with identification codes, which is a population of cells that can be distinguished from one another based on a difference in luminescent signals emitted by luminescent substances, wherein the difference in the luminescent signals is caused by either or both (a) ... 09/22/05 - 20050208478 - Support with crosslinked marine collagen for tissue engineering and manufacture of biomaterials The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least ... 09/22/05 - 20050208477 - Raised surface assay plate The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimentation. The sample receiving surface preferably has at least one sharp ... 09/22/05 - 20050208476 - Three-dimensional ex vivo angiogenesis system An in vitro tissue angiogenesis and vasculogenesis system is disclosed that allows the outgrowth of microvessels from a three-dimensional tissue fragment implanted in a matrix. The matrix may, for example, be a fibrin- or collagen-based matrix fed by a growth medium, for example, a mixture of tissue culture medium, serum, ... 09/22/05 - 20050208475 - Process and apparatus comprising episcopic differential contrast (edic) microscopy plus epifluorescence microscopy (ef) for the detection or identification of biological materials on surfaces The present invention relates to a microscopy system for rapid and sensitive detection and identification of biological material on surfaces by implementing episcopic differential contrast (EDIC) microscopy plus epifluorescence (EF) microscopy wherein the microscope incorporates a DIC prism in the nosepiece and long distance objectives so that the materials can ... 09/22/05 - 20050208474 - Method and cell composition for screening compounds for anti-inflammatory activity A method and cell line for screening test compounds for antiinflammatory activity are disclosed. The cell line is a human cell line capable of producing a selected cytokine associated with an inflammatory response in humans, and transfected with (i) a vector containing DNA encoding a cytokine regulatory factor under the ... 09/22/05 - 20050208473 - Decision-making spectral bioreactor This invention fills several voids in bioreactor technology that allows efficient connection of aspects of physical science (optics, electronics, physical chemistry, sensors) to aspects of microbial and cell culture physiology in a uniquely interactive manner. This is accomplished mathematically through decision making software that utilizes detected changes in the course ... 09/22/05 - 20050208472 - Modulators of angiogenesis The present invention relates to regulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis; as well as to the use of expression profiles and compositions in ... 09/22/05 - 20050208471 - Method of characterizing potential therapeutics by determining cell-cell interactions A method quantitatively analyzes images of two different cell types that interact in producing and maintaining a disease state or other biological condition. The two separate cell types are exposed to an agent or stimulus suspected of influencing the biological condition (e.g., the agent might be a potential therapeutic for ... 09/22/05 - 20050208470 - Toll-like receptor assays Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR are described. Methods of identifying molecules that interact with a TLR are also described. ... 09/22/05 - 20050208469 - Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting the mixture and polymerizing. The array ... 09/22/05 - 20050208468 - Assays with primary cells Systems, including methods, apparatus, compositions, and kits, for performing assays with primary cells. ... 09/22/05 - 20050208467 - Micro-pattern embedded plastic optical film device for cell-based assays In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a coordinate system that allows identification of each location on the ... 09/22/05 - 20050208466 - Method of selective isolation or visualization of target cells differentiated from embryonic cells or kit for visualization A method for selectively isolating or visualizing a target cell differentiated from an embryonic stem cell, which comprises transferring a first recombinant DNA in which a first promoter, a gene having recombinase recognition sequences on both ends, and a selective marker gene of a target cell differentiated from an embryonic ... 09/22/05 - 20050208465 - Method of apparatus for collecting micromaterial A substance (for example, methylcellulose) that undergoes a reversible gel to sol phase transition is utilized in a recovery method for specific micromaterials such as DNA molecules, cells, microorganisms and the like, approximately several μm in size, from a mixture containing other micromaterials, and a micromaterial is accurately and conveniently ... 09/22/05 - 20050208464 - Apparatus for retaining magnetic particles within a flow-through cell An apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell comprises (a) optionally, an electrical current source; (b) an electromagnet having a winding connected to the current source and an air gap between at least one pair of poles ... 09/15/05 - 20050202412 - Serotonergic agents with long-acting in vivo effects have a long duration of action and are useful for the treatment of chronic diseases resulting from the dysfunction of the serotonergic 5-HT1A system, such as schizophrenia and other psychotic disorders such as paranoia and mano-depressive illness. ... 09/15/05 - 20050202411 - Precise efficacy assay methods for active agents including chemotherapeutic agents An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best ... 09/15/05 - 20050202410 - Precise efficacy assay methods for active agents inlcluding chemotherapeutic agents An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly ... 09/15/05 - 20050202409 - Method of predicting thermostable protein from mesophilic bacteria based on amino acid composition of thermophilic bacteria and its closely related methophilic bacteria, predicting program therefor and recording medium thereof The invention relates to a method of judging the thermostability of a protein, comprising the steps of calculating an analytical value specific to a test protein by a principal component analysis based on the amino acid composition of the protein calculated from the data of the amino acid sequence of ... 09/15/05 - 20050202408 - Chemical screening using a proline-rich nuclear receptor co-regulatory protein/nuclear receptor co-expression system Assays are presented for screening for chemicals which affect the binding between proteins comprising an SH3 binding motif and nuclear receptor proteins. PNRC (Proline-rich Nuclear Receptor Co-regulatory protein) is a co-regulatory protein comprising an SH3 binding motif and was identified using bovine SF1 as the bait in a yeast two-hybrid ... 09/15/05 - 20050202407 - Methods and assays for screening anti-neoplastic therapeutic agents The present invention provides methods and assays for screening and identifying agents that will be useful in the treatment and prevention of neoplastic disorders. The methods and assays of the present invention are particularly useful for identifying therapeutic agents for steroid sensitive neoplastic disorders such as prostate cancer. ... 09/15/05 - 20050202406 - Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the ... 09/15/05 - 20050202405 - Methods, compositions, and kits for protein crystallization The present invention provides methods, compositions, and kits for protein crystallization. The present invention involves electrophoretically focusing at least a first protein species within a matrix comprising at least 2 regions of different pH, the protein being present in amount sufficient to permit crystallization within said pH gradient. ... 09/15/05 - 20050202404 - Method for separating a cell group contained in a sample into individual cells In a method for separating a cell group contained in an image of a sample into individual cells for a subsequent classification of the sample, wherein the cell group has a plurality of mutually overlapping cells, first a cell nucleus of a first cell which is to be separated from ... 09/15/05 - 20050202403 - Yeast cells expressing modified g proteins and methods of use therefor The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coupled receptors. Specifically, the invention provides ... 09/15/05 - 20050202402 - Tandem signaling assay Chemical, biological, and/or biochemical assays of the invention utilize intermediate binding entities for binding interactions. For example, a colloid particle carrying a species that could harm a component in the assay is allowed to binding interact in the assay only after other, more sensitive components have finished their binding interactions. ... 09/15/05 - 20050202401 - Nucleic acid sequences found in drosophilia melanogaster that encode proteins essential for viability and method of use Within the unique Triplo-lethal region (Tpl) of the Drosophila melanogaster genome we have found a cluster of 20 genes encoding a novel family of proteins. This family is also present in the Anopheles gambiae genome and displays remarkable synteny and sequence conservation with the Drosophila cluster. The family is also ... 09/15/05 - 20050202400 - Method of classifying counting leucocytes There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the ... 09/15/05 - 20050202399 - Method of assay by oxidation-reduction reaction with formazan The present invention provides a highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a formazan compound is added to a sample prior to a redox reaction so as to eliminate the influence of any reducing substance in the sample. Thereafter, a ... 09/15/05 - 20050202398 - Use of biological photoreceptors as directly light-activated ion channels Use of a biological photoreceptor as light-controlled ion channel for the alteration of the ion conductivity of a membrane by means of light. The photoreceptor used comprises an apoprotein and a light-sensitive polyene covalently bound to the apoprotein, said polyene interacting with the apoprotein and functioning as a light-sensitive gate. ... 09/15/05 - 20050202397 - Method and device for determining the hematocrit and/or blood volume A method for determining the hemocrit and/or blood volume during an extracorporeal blood treatment with an extracorporeal blood circuit, in which blood is taken with a blood pump via an arterial cannula and an arterial flexible-tube line and blood is fed back via a venous flexible-tube line and a venous ... 09/15/05 - 20050202396 - Surface-attached polyfunctional polymer networks for sensor chips The invention relates to polyfunctional polymer networks comprising an assembly of cross-linked polymer subchains attached to a surface, with each polymer subchain comprising a multitude of identical or different repeating units carrying one or more functional groups which allows an interaction with a sample or probe molecule. ... 09/08/05 - 20050196748 - Method and device for monitoring platelet function The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the ... 09/08/05 - 20050196747 - Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid This invention provides a device for determining the concentration of an analyte like glucose, cholesterol, free fatty acids, triglycerides, proteins, ketones, phenylalanine or enzymes, in a physiological or aqueous fluid like blood, serum, plasma, saliva, urine, interstitial and/or intra-cellular fluid, the device having an integrated calibration and quality control system ... 09/08/05 - 20050196746 - High-density ion transport measurement biochip devices and methods The present invention provides novel biochips, biochip-based devices, and device configurations that can be used for ion transport measurement. The chips, devices, and designs of the present invention are particularly suited to high-throughput assays such as compound screening assays using patch clamping techniques. The invention includes high-density biochips made by ... 09/08/05 - 20050196745 - Guided deposition in spatial arrays An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in ... 09/08/05 - 20050196744 - Method of screening cocaine antagonists The present invention provides a method of screening for antagonists of cocaine and other abused psychostimulants that exert their effects via the dopamine transporter protein, of therapeutic value in treating psychostimulant addiction. More particularly, the invention provides a method of screening for compounds that prevent inhibition of dopamine transport by ... 09/08/05 - 20050196743 - Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those ... 09/01/05 - 20050191616 - Method of stabilization of functional nanoscale pores for device applications A membrane is disclosed made from a compound having a hydrophilic head group, an aliphatic tail group, and a polymerizable functional group. The membrane spans an aperture and may be polymerized. The membrane may be useful for DNA sequencing when the membrane includes an ion channel. ... 09/01/05 - 20050191615 - Method for analysis of cell structure, and cell structure A method for analysis of a cell structure includes a macroanalysis step and a microanalysis step. The macroanalysis step includes replacing a cell structure or a part of the cell structure with an anisotropic solid body having property values of equivalent rigidity characteristics, creating a finite element model of the ... 09/01/05 - 20050191614 - High-throughput formation, identification and analysis of diverse solid forms The invention concerns arrays of solid-forms of substances, such as compounds and rapid-screening methods therefor to identify solid-forms, particularly of pharmaceuticals, with enhanced properties. Such properties include improved bioavailability, solubility, stability, delivery, and processing and manufacturing characteristics. The invention relates to a practical and cost-effective method to rapidly screen hundreds ... 09/01/05 - 20050191613 - Device for monitoring cells The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of ... 09/01/05 - 20050191612 - Method of screening insulin content enhancer A screening tool for an agent for promoting insulin production and/or an agent for increasing insulin content, wherein the tool is a G protein-coupled receptor exhibiting an activity of promoting insulin production by activation, or a cell expressing the polypeptide, is disclosed. Further, a method for screening an agent for ... 08/25/05 - 20050186559 - Abeta42 lowering agents The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ38 are increased, and levels of Aβ40 are unchanged. The invention provides methods and ... 08/25/05 - 20050186558 - Treatment of diabetes with milk protein hydrolysate A milk protein hydrolysate which is preferably caseinoglycomacropeptide and/or a whey protein in a bioavailable form is used for the manufacture of a composition for the treatment or prevention of diabetes or syndrome X. The invention also relates to a method of treatment or prevention of diabetes or syndrome X ... 08/25/05 - 20050186557 - Cytotoxicity assay Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel containing living cells in culture medium. The cells are then incubated for a pre-determined amount of time. ... 08/25/05 - 20050186556 - Cell migration assay The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers. ... 08/25/05 - 20050186555 - Naphthofluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to naphthofluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... 08/25/05 - 20050186554 - Image analysis and assay system Systems for determining and/or analyzing the distribution and dynamics of cellular components. ... 08/18/05 - 20050181354 - Methods of assaying physiological states The present application provides, among other things, methods for monitoring biological states in a subject, as well as methods for monitoring the effect of interventions or therapies upon the biological states of a subject. ... 08/11/05 - 20050175984 - Molecular device, molecule array, rectifier device, rectifying method, sensor device, switching device, circuit device, logical circuit device, operational device and information processing device A rectifier device, based on a novel operation principle completely different from that of conventional molecular electronic devices, is made by coupling two or more molecules or molecule arrays (11) at certain joints. By making use of the phenomenon that transfer of an excited state or exciton from one molecule ... 08/11/05 - 20050175983 - Reagent kit for detecting lupus anticoagulunt A first aspect of the present invention relates to a reagent kit for detecting lupus anticoagulant comprising a first coagulation time measurement reagent containing phospholipid including phosphatidylserine and phosphatidylethanolamine and a second coagulation time measurement reagent containing phospholipid including phosphatidylserine and phosphatidylethanolamine wherein the concentration of phosphatidylethanolamine of said first ... 08/11/05 - 20050175982 - Intracellular metabolic flux analysis method using substrate labeled with isotope A method for intracellular metabolic flux analysis comprising (a) culturing cells in a medium not containing any isotope-labeled substrate to a target phase of the metabolic flux analysis, (b) adding an isotope-labeled substrate to the medium, and continuing culture and collecting samples from the medium in time course, (c) measuring ... 08/11/05 - 20050175981 - Microscale sorting cytometer The present invention provides a device and methods of use thereof in microscale cell sorting. This invention provides sorting cytometers, which trap individual cells within vessels following exposure to dielectrophoresis, allow for the assaying of trapped cells, such that a population is identified whose isolation is desired, and their isolation. ... 08/11/05 - 20050175980 - Quantitative assay of the angiogenic and antiangiogenic activity of a test molecule A method of measuring the angiogenic or antiangiogenic activity of a test molecule comprising (i) utilizing a modified CAM assay to assign an FVD value for a test region of interest and comparing this value to an FVD value for a control region of interest, or (ii) utilizing a modified ... 08/11/05 - 20050175979 - Methods for absolute cell counting The invention concerns a method for determining the absolute cell count of an identifiable cell sub-population contained in a sample by introducing into an aliquot of said biological sample a pre-determined amount of a fluid reagent comprising a known concentration of fixed and labelled cells; then using flow cytometry to ... 08/04/05 - 20050170332 - Measuring method and measuring device The measuring device according to the present invention has a support on which cells to be observed are arranged, an imaging lens that forms an image of reflected light reflected from the cells at an image capturing position as a result of being irradiated with excitation light, and a photoelectric ... 08/04/05 - 20050170331 - Method for characterizing metabolic stability of a drug An NMR based method for characterising the metabolic stability of a drug candidate comprising the steps of enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed “hyperpolarisation”), contacting the drug candidate with liver cells or cell organelles, and carrying out NMR analysis. ... 08/04/05 - 20050170330 - Angiogensis models using nestin-expressing stem cells to image nascent blood vessels The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. ... 08/04/05 - 20050170329 - Screening assays using intramitochondrial calcium The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens ... 08/04/05 - 20050170328 - Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell, wherein at least two different samples taken during the purification process of the pharmaceutical product are incubated with at least one protein biochip array and in that the contaminants bound ... 07/28/05 - 20050164162 - Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities The present invention relates to the field of selecting cells producing compounds that fulfil at least 2 predetermined functionalities. The invention primarily focuses on methods for screening of cells for two or more functionalities related to small molecules generated by host cells with novel gene assemblies. The methods in one ... 07/28/05 - 20050164161 - Electrical field stimulation of eukaryotic cells Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the open/close state transition of the voltage-gated ion channels. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled ... 07/28/05 - 20050164160 - Method and device for the measurement of chemical and/or biological samples A device for the measurement of chemical and/or biological samples, in particular by means of luminescence spectroscopy, comprises an irradiation unit (12), a sample receiver (10), at least one optical unit (30) and a detector unit (40). Electromagnetic radiation of various wavelength ranges and/or polarizations are led from the sample ... 07/21/05 - 20050158706 - Methods and compositions for the differentiation of human preadipocytes into adipocytes The present invention provides methods and compositions for the consistent and quantitative differentiation of human preadipocytes isolated from adipose tissue into adipocytes bearing biochemical, genetic, and physiological characteristics similar to that observed in isolated primary adipocytes. The methods of the invention comprise incubating isolated human preadipocytes, plated at least about ... 07/21/05 - 20050158705 - Gene screening method using nuclear receptor A system in which a ligand is formed by the expression of a polypeptide that converts a ligand precursor into a ligand, and the ligand thus formed binds to a nuclear receptor to thereby induce the expression of a reporter gene located downstream of the target sequence is constructed. Searching ... 07/21/05 - 20050158704 - Method of analyzing blood A method of analyzing blood comprises delivering a blood sample to a test device, applying a spatially varying electric field to the blood sample to provide a depleted cell concentration in a portion of the blood sample, and sensing a property of the portion of the blood sample. ... 07/21/05 - 20050158703 - Cytocapacity test for the prediction of the hematopoietic recovery, neutropenic fever, and antimicrobial treatment following high-dose cytotoxic chemotherapy The present invention relates to a method for determining the hematopoietic cytocapacity of a subject comprising the steps of: (a) determining the amount of leukocytes present in a blood sample obtained from a subject, wherein said subject has been subjected to administration of a single dose of G-CSF and has ... 07/21/05 - 20050158702 - Cellular arrays comprising encoded cells A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and biological materials, are deployed in a plurality of discrete sites on a substrate. In a preferred embodiment, the discrete sites comprise microwells ... 07/14/05 - 20050153275 - Kits for measuring cellular transmembrane potential changes The invention encompasses kits for an improved method for measuring membrane potential using compounds of the formula I as potentiometric probes. These probes may be used in combination with other fluorescent indicators such as Indo-1, Fura-2, and Fluo-3, such probes may be used in microplate reading devices such as FLIPR™, ... 07/14/05 - 20050153274 - Methodology of using raman imaging microscopy for evaluating drug action within living cells A method of using Raman imaging microscopy to evaluate drug actions in living cells is disclosed. Specifically the invention describes the methods of using Raman imaging microscopy to detect drug uptake, distribution, binding, and metabolism in a single cell, and to study drug pharmacokinetics at the cellular level. The method ... 07/14/05 - 20050153273 - Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opposite second ... 07/07/05 - 20050147960 - In vitro development of tissues and organs A method for producing a differentiated tissue is provided, which method comprises isolating at least one population of homogeneous multipotent cells, and culturing the cells in the presence of at least one differentiation factor, wherein the cells are supported by a solid phase scaffold. Differentiated tissues produced by this method, ... 06/30/05 - 20050142534 - Methods and compositions related to a matrix chip Embodiments of the invention relate to devices and methods for evaluating the interactions between cells and between cells and matrix materials wherein the cellular distribution patterns formed as a result of such interactions are indicators of the invasive potential(s) of the cells. Furthermore, such devices and methods can provide indications ... 06/30/05 - 20050142533 - Compositions and methods for promoting nerve regeneration Analogs of FK506 that do not bind FKBP-12 have been found to effectively promote nerve cell growth and regeneration, thereby speeding functional recovery of damaged nervous tissue and axonal regeneration without causing immunosuppression. ... 06/23/05 - 20050136394 - Cell-based assay for identifying peptidase inhibitors The present invention provides assays for the identification of inhibitors of endopeptidase toxins. The assays utilize genetically engineered yeast cells that contain a conditionally expressed endopeptidase toxin. When conditions for expression of the toxin are met, the toxin cleaves a yeast (natural or engineered) peptide product that is required for ... 06/23/05 - 20050136393 - Oligodoxynucleotide (odn) libraries, their use in screening for antibacterial agents, and catalytic odn sequence for use as an antibacterial agent A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial gene(s) related to cell growth and toxin production and secretion. The screening library ... 06/23/05 - 20050136392 - Amplification of enzymatic reactions for use with an enthalpy array Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring. ... 06/16/05 - 20050130122 - Male fertility assay method and device A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm ... 06/16/05 - 20050130121 - Analysis of chemically crosslinked cellular samples A method of analyzing cellular samples that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry. ... 06/16/05 - 20050130120 - Devices for the detection of multiple analytes in a sample The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore. ... 06/16/05 - 20050130119 - Real-time impedance assay to follow the invasive activities of metastatic cells in culture The present invention provides methods for the assessment of the metastatic potential of cells by measuring the effect of the cells on the impedance of an electrode. Accordingly, the present invention similarly provides methods for testing the efficacy of anti-cancer therapies and for establishing indicators of metastatic potential based on ... 06/16/05 - 20050130118 - Methods for identifying inhibitors of chlorophyll synthase The present inventors have discovered that antisense suppression of a chlorophyll synthase (CS) gene results in plants exhibiting one or more of chlorosis, reduced growth, and altered development. Thus, the present inventors have discovered that the protein encoded by the CS gene is essential for normal plant growth and development, ... 06/16/05 - 20050130117 - Modulators of lymphocyte activation and migration The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLCγ1, PAG, SHP/PTP1C, CSK, ... 06/16/05 - 20050130116 - Stable expression of polymorphous forms of human cytochrome p450 2d6 The present invention relates to a test system containing cell lines expressing human cytochrome P450 2D6 as well as to the use of said test system for the study of pharmacological and toxicological aspects of the hCYP2D6 polymorphism. The present invention further relates to methods for the detection of novel ... 06/09/05 - 20050123897 - Method for the improvement of transport across adaptable semi-permeable barriers The invention relates to a method, a kit and a device for controlling the flux of penetrants across an adaptable semi-permeable porous barrier the method comprising the steps of: preparing a formulation by suspending or dispersing said penetrants in a polar liquid in the form of fluid droplets surrounded by ... 06/09/05 - 20050123896 - Screening system for modulators of her2 mediated transcription and her2 modulators identified thereby This invention pertains to the development of a screening system to identify (screen for) HER2 promoter silencing agents. Such agents are expected to be of therapeutic value in the treatment of cancers characterized by HER2 amplification/upregulation. In addition, this invention pertains to the discovery that histone deacetylase (HDAC) inhibitors like ... 06/02/05 - 20050118565 - Systems and methods for assessing neuronal degeneration The invention relates to systems and methods for assessing neuronal degeneration in vitro. A multielectrode probe is used to culture and measure synaptic transmission of a neuronal sample in the presence of various compounds and culturing conditions capable of inducing or protecting against neuronal damage. ... 06/02/05 - 20050118564 - Methods and compositions for identification and therapeutic use of genes involved in vascular and proliferative diseases The present invention comprises compositions and methods for identification of genes involved in vascular diseases using human endothelial and smooth cell “artery wall” models to capture the cell-cell and cell-matrix communications that are operative in normal and diseases conditions. The present invention further comprises the capture of the complexity of ... ### FreshPatents.com Support - Terms & Conditions |