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Chemistry: Molecular Biology And Microbiology > Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test StripMeasuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.06/07/07 - 20070128585 - (+)-trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a ... 06/07/07 - 20070128584 - Method for isolation of cells A method is disclosed for separating selected cells that have cell membranes which are selectively-permeable to a given solute from other non-selected cells. The combination of cells are exposed to the given solute and thereafter the cells are exposed to low or zero-solute solution to thereby osmotically shock and destroy ... 05/31/07 - 20070122797 - System for tracking biological samples Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection ... 05/31/07 - 20070122796 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same A basement membrane having a barrier function is formed by culturing alveolar epithelial cells or vascular endothelial cells on a fibrous collagen matrix coated with a polymer having a sugar chain that can localize a receptor that has an activity to accumulate a basement membrane component on the basal surface ... 05/31/07 - 20070122795 - Information processing apparatus, information processing method, information processing system, program, and recording medium Disclosed herein is an information processing apparatus, method, system, and program, and a recording medium. An information processing apparatus includes an acquisition unit, an arithmetic unit, and an output control unit. The acquisition unit acquires the amount of the molecules for detection which have been produced by control cells and ... 05/24/07 - 20070117087 - Method of providing readily available cellular material derived from peripheral blood, and a compositoin thereof Method of researching disease states using TVEMF-expanded cells. ... 05/24/07 - 20070117086 - Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to ... 05/17/07 - 20070111199 - Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as ... 05/17/07 - 20070111198 - Nanopatterned surfaces and related methods for selective adhesion, sensing and separation Nanodimensioned heterogeneous surface compositions and configurations, related systms ad methods for sensing particle or analyte interaction therewith. ... 05/17/07 - 20070111197 - Sample analyzer and sample analyzing method A sample analyzer comprising: a measurement section for measuring a sample of an animal; a memory for storing a measurement data by the measurement section; an analysis section for analyzing the measurement data stored on the memory in accordance with a first analysis condition corresponding to a previous setting of ... 05/17/07 - 20070111196 - Sterilization of biosensors The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and ... 05/17/07 - 20070111195 - Toxicity typing using liver stem cells This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and ... 05/17/07 - 20070111194 - Method for the concentration and purification of biological compounds The invention concerns materials and methods used for the concentration, desalination, purification or stabilization of biological compounds, in particular biological macromolecules and supramolecular structures, by means of superabsorbent polymers or superabsorptive composite materials. ... 05/17/07 - 20070111193 - Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation. ... 05/17/07 - 20070111192 - Detection of protein interactions The present invention relates to a method of detecting interactions, particularly peptide to peptide interactions, using fluorescence. Nucleic acids encoding fragments of fluorescent protein, a peptide of interest and a linker portion of different lengths interposed between the peptide of interest and a fragment of fluorescent protein is provided together ... 05/10/07 - 20070105089 - Interactive transparent individual cells biochip processor An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location. ... 05/10/07 - 20070105088 - Light scattering determination of treatment potencies Potencies (44) of treatments effecting cells (11) are measured by difference (42) between angular intensity distributions of light scattered by treated cells and by untreated cells. ... 05/10/07 - 20070105087 - Biological tissue processing substrate, processing apparatus, processing method and processing kit A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of ... 05/10/07 - 20070105086 - Compositions and methods for identifying modulators of trpv2 It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2. ... 05/10/07 - 20070105085 - Crystal of a transporter-ligand complex and methods of use The invention relates to the three-dimensional structure of a crystal of a transporter protein complexed with a ligand. The three-dimensional structure of the transporter-ligand complex is disclosed. The transporter-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug ... 05/03/07 - 20070099176 - Methods of expressing lim mineralization protein Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding ... 05/03/07 - 20070099175 - Modified fluorescent proteins Functional red fluorescent proteins, nucleic acids encoding them, and methods for their use. ... 05/03/07 - 20070099174 - Rapid testing for nutrients This invention presents the rapid testing for nutrients in products including, but not limited, medicines, food supplements or additives, cosmetics, drinks, fruits, vegetables, and etc. The rapid testing is performed on strips coated with indicators. Nutrients such as Vitamin C can be detected in very small volume. The detection is ... 05/03/07 - 20070099173 - Electronic device for communication with living cells The present invention provides a surface-substrate for adherence of cells thereto. The surface-substrate comprises at least one micronail structure protruding from the surface, at least a region of the micronail having cellular-internalization promoting properties. The invention also provides an electronic device comprising a transistor structure, in which a gate electrode ... 04/26/07 - 20070092865 - Detection and characterization of psychoactives using parallel multi-site assays in brain tissue This invention relates to methods and devices for the detection and characterization of psychoactive compounds by analyzing alterations of network level physiological characteristics before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample. The invention further provides a software package that enables an operator ... 04/26/07 - 20070092864 - Treatment planning methods, devices and systems Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one ... 04/26/07 - 20070092863 - Methods and agents of decalcifying bone Decalcification can be performed by using acid or other agents. It may be difficult to decalcify large bone block within ours. This invention provides a bone-decalcifying agent including a calcium desolving agent for desolving calcium ions of bones, and a bubble-forming agent for generating microbubbles when the bone-decalcifying agent is ... 04/26/07 - 20070092862 - Flow sensors for penile tumescence The disclosure describes blood flow sensors for detecting penile tumescence. A system according to the invention may include at least one sensor for sensing blood flow into the penis, and one sensor for sensing blood flow away from the penis. Detecting penile tumescence may be accomplished by comparing the flow ... 04/26/07 - 20070092861 - Environments that maintain function of primary liver cells Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, lamninin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present ... 04/19/07 - 20070087329 - Serum replacement for thyroid hormone-responsive cell culture A low thyroid hormone serum supplemented culture medium is provided comprising serum prepared from non-mammalian vertebrates having a developmental stage with low endogenous thyroid hormone (T3 and T4) levels; and a culture medium. The culture medium is for the study of cellular responses to thyroid hormones or chemicals that induce ... 04/19/07 - 20070087328 - Method of coating lipid membranes Method for the manufacturing of a supported lipid membrane comprising: providing a substrate, covered at least in part with a layer comprising proteins, glycoproteins, polypeptides and/or peptides; contacting and incubating said substrate with a solution comprising bicelles, which comprise at least one short chain and at least one long chain ... 04/19/07 - 20070087327 - Method and kit-of-parts for the electrophysiological examination of a membrane comprising an ion channel The invention relates to a collection (kit-of-parts) for producing a high electrical resistance in an electrophysiological examination of a membrane comprising an ion channel, comprising a first electrolytic solution and a second electrolytic solution, wherein the first electrolytic solution comprises 20-140 mM divalent cations of a first element and the ... 04/19/07 - 20070087326 - Method of measuring the biological activity of an urotensin ii receptor Administration of U-II to a cell having a functional urotensin II receptor caused an increase in the electrical impedance of the cell in a receptor specific and dose dependent manner. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the electrical impedance ... 04/19/07 - 20070087325 - Method of screening for cell colonies that express a soluble variant of a target protein The present invention concerns a method of identifying a cell colony which expresses a soluble variant of a target protein which method comprises (a) subjecting the cell colony to conditions which are capable of causing lysis thereof; (b) filtering the lysate through a filter having pores which allow only soluble ... 04/12/07 - 20070082329 - Infertility assessment and treatment system A method for assessing fertility for a couple that includes obtaining semen analysis results from a male member of the couple, obtaining fertility survey responses from at least a female member of the couple, determining an initial location in a diagnostic matrix using the semen analysis results and the fertility ... 04/12/07 - 20070082328 - Rotatable time varying electromagnetic force bioreactor and method of using the same A rotatable time varying electromagnetic force bioreactor comprising a culture chamber having an interior portion that removably receives a cell mixture and an exterior portion with an electrically conductive coil wrapped around the exterior portion, a motor for rotating the culture chamber, and a time varying electromagnetic force source operatively ... 04/12/07 - 20070082327 - Cellular phenotype Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may ... 04/05/07 - 20070077552 - High throughput screen for inhibitors of polypeptide aggregation We have developed a high through-put screen capable of isolating inhibitors of polypeptide aggregation, such as Alzheimer's Disease polypeptide Aβ aggregation, or other disease state aggregating proteins, from amidst large libraries of candidate inhibitors. The screen uses a fusion of a polypeptide domain that self-aggregates, such as an Aβ42 domain ... 04/05/07 - 20070077551 - Sample analyzer A sample analyzer for analyzing samples of a plurality of species of animals, comprising: a display; a memory for storing first icon data representing a first icon and second icon data representing a second icon, the first icon showing a first species of animal and being used for selecting a ... 04/05/07 - 20070077550 - Sample imaging apparatus, sample analyzing apparatus, and sample imaging method A sample imaging apparatus comprising: a sample image obtainer for obtaining an image of a sample smeared on a sample holder, the sample holder comprising an identification part which comprises identification information of the sample; an identification detector for detecting the identification information; an identification part image obtainer for obtaining ... 04/05/07 - 20070077549 - Violet laser excitable dyes and their method of use The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates. ... 04/05/07 - 20070077548 - Method for determination of cardiovascular risk factors in dried blood A method for the determination of cardiovascular risk factors in biological samples that comprising the steps of a) sampling, b) altering the sample into a dry blood sample c) conducting a sample preparation where appropriate and d) analysing the sample to offer a simple yet effective method for the determination ... 04/05/07 - 20070077547 - Assay assembly A cell based assay assembly includes a biochip assembly, a liquid delivery unit and detection and recording equipment is used for conducting an assay on a biological cell as it is delivered through the biochip assembly. The biochip assembly includes a plurality of separate biochips each comprising a microchannel with ... 03/29/07 - 20070072172 - Liver specific chimeric regulatory sequence and use thereof The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5 flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other ... 03/29/07 - 20070072171 - Solid surface for biomolecule delivery and high-throughput assay The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules. ... 03/29/07 - 20070072170 - Methods of determination of responsiveness to erythropoietin treatment Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; comparing VHf to a predetermined criterion; and reporting indication of ... 03/29/07 - 20070072169 - Process and apparatus for measuring binding events on a microarray of electrodes There is disclosed a process and apparatus for reading electrical current of electrodes on a microarray of electrodes. Those electrodes having binding events are detected by a difference in electrical current flow. Enzymes on targets catalyze the conversion of substrate to product, which is detectable by electrochemical reduction at each ... 03/29/07 - 20070072168 - Microplate sample tracking system The invention provides sample tracking systems and methods. A sample tracking system can comprise a plate having a plurality of sample wells and an apparatus for illuminating each individual sample well, wherein the manner with which the sample well is illuminated can track the loading of the sample components to ... 03/29/07 - 20070072167 - Tissue binding composition The invention relates to a tissue binding composition. The inventive composition is characterised in that it comprises: between 40 g/l and 80 g/l trehalose, preferably approximately 60 g/l; between 40% and 80% (v/v) ethanol, preferably approximately 70% (v/v): between 0% and 5% (v/v) acetic acid, preferably approximately 1% (v/v); and ... 03/22/07 - 20070065808 - Method and apparatus for sorting particles A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing ... 03/22/07 - 20070065807 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; a method for constructing a specimen of a basement membrane; a process ... 03/22/07 - 20070065806 - Gel spot picker The present invention relates to a gel sheet (1) for use in a spot picker device wherein said gel sheet is provide with reference marks (5′-5′″) which can be used to determine if the gel sheet (1) has been deformed between the stages of scanning the gel sheet and picking ... 03/22/07 - 20070065805 - Cell migration assay The present invention provides compositions and methods for preparation of a three-dimensional transendothelial cell migration (TEM) assay. These compositions and methods are uniquely suited for the high throughput TEM assay, and for the analysis and identification of TEM mediators which inhibit or stimulate this process. The composition for detecting migration ... 03/22/07 - 20070065804 - Method for pr-39 peptide mediated selective inhibition of ikappabalpha degradation The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are ... 03/22/07 - 20070065803 - Patterns for a skeletal system The present invention relates to a bone system model comprising a mineralized matrix and osteoblasts, chararacterized in that the osteoblasts are deposited onto the matrix so as to form a layer at confluence and/or nodules, and the osteoclasts are deposited onto said layer and/or said nodules, and also to bone ... 03/22/07 - 20070065802 - Method and system for measuring the penetration of drugs and other substances into tissue The failure of many anticancer drugs to control growth of solid cancers may stem in part from inadequate delivery to tumor regions distant from vasculature. However, extricating the effect of tissue penetration from the many other factors that affect a drug's efficacy in tumors with distance from vasculature is generally ... 03/22/07 - 20070065801 - Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4) The invention provides a human 5-HT4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver ... 03/15/07 - 20070059680 - System for cell enrichment The present invention provides systems useful for the enrichment of analytes, for example, cells of selected types, including but not limited to blood cells, stem cells, and pathogens, in samples. The invention also provides methods for analyzing the condition of a patient based on characteristics identified through analysis of the ... 03/15/07 - 20070059679 - Method for demonstrating efficacy of a topically applied active ingredient A method is disclosed for demonstrating the efficacy of a topically applied active ingredient, which method includes topically applying a composition containing an active ingredient to an area of skin, applying an absorbent material to the area of skin to extract at least a portion of the active ingredient from ... 03/15/07 - 20070059678 - Breast milk contaminant detection device A breast milk detection device includes a plurality of test strips slidably and removably coupled to a test housing. Each test strip is connected to an absorbent section so that a breast milk sample deposited thereon is communicated to the test strips. Each test strip includes an analyte-specific moiety for ... 03/08/07 - 20070054261 - Methods for retail measurement of skin moisture content Methods provide for measuring scalp moisture content of a consumer. More particularly, the present invention is directed to a method comprising the steps of: (a) collecting input information from said consumer regarding a plurality of characteristics associated with hair and scalp condition of said consumer; (b) providing a moisture meter ... 03/08/07 - 20070054260 - Pharmacodynamic assays The invention provides methods for quickly and easily screening mixed cell samples for a pharmacodynamic effect to a drug or test agent. ... 03/08/07 - 20070054259 - Modulation of hnrnp h and treatment of dm1 The present invention is directed to the discovery that the heterogeneous nuclear ribonucleprotein H (hnRNP H) is capable of binding mutant myotonic dystrophy (DM) protein kinase (DMPK) mRNA. The present invention is also directed to the discovery that modulation of the expression of hnRNP H results in reduced nuclear retention ... 03/01/07 - 20070048734 - Novel enhanced processes for drug testing including neoplasmic tissue slices and products thereby A novel method for testing neoplasmic tissue in a testing system is more effective than conventional cell culture systems and functions by treating the neoplasmic tissue slice system's samples with at least one compound and observing the effect on the neoplasmic tissue slices resident therein, or cells, tissue samples or ... 03/01/07 - 20070048733 - Novel enhanced processes for drug testing and screening using human tissue A novel method for testing human tissue in a testing system is more effective than conventional cell culture systems and functions by treating the human tissue slice system's samples with at least one compound and observing the effect on the human tissue slices resident therein, or cells, tissue samples or ... 03/01/07 - 20070048732 - Chemosensitivity tester A novel method for testing the chemosensitivity of a substance in a bioartificial tissue slice system is more effective than conventional cell culture systems and function by treating the bioartificial tissue slice system's samples with at least one compound and observing the effect on the bioartificial tissue slices resident therein, ... 03/01/07 - 20070048731 - High throughput use-dependent assay based on stimulation of cells on a silicon surface The invention pertains generally to the field of drug discovery science. More specifically, the invention refers to a drug screening assay and device that is used to test the effect of specific chemical compounds as use dependent ion channel blockers. The invention includes a unique method for stimulating cells with ... 03/01/07 - 20070048730 - Global alignment of sequence data To determine optimal alignment of two molecules, an alignment space of two strings representing element sequences of the molecules is conceived as a grid of cells, where each cell represents alignments between substrings of the two strings. The cells are tested against conditions that are framed, in the context of ... 03/01/07 - 20070048729 - Method of creating a collection of biological specimens, and collection of specimens The invention relates to a method of creating a collection of isolated biological specimens, wherein each isolated biological specimen is preserved within a defined length of time following isolation of the specimen from its natural environment and is subsequently stored, and wherein the defined length of time between isolation and ... 03/01/07 - 20070048728 - Hydroxylases and modulators thereof A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates ... 02/22/07 - 20070042347 - High throughput biological heart rate monitor that is molecularly determined This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and ... 02/22/07 - 20070042346 - Method and apparatus for detection of rare cells Fluorescent dye-tagged rare cells are disposed in a biological fluid layer contained in an annular gap (12) between an inside test tube wall (14) and a float wall (16). One or more analysis images are acquired at one or more focus depths using a microscope system (10, 10′, 10″, 10′″). ... 02/22/07 - 20070042345 - Polypeptide having intracellular calcium ion indicator function The present invention provides a polypeptide having an intracellular calcium ion indicator function, which contains the following elements (a)-(c): (a) a polypeptide residue consisting of a membrane localization signal sequence; (b) a first fluorescent polypeptide residue; and (c) a second fluorescent polypeptide residue in the order of (a), (b) and ... 02/22/07 - 20070042344 - Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient The present invention relates to a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into natural killer cells as an effective ingredient, more precisely, a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into premature natural killer cells as an effective ingredient ... 02/22/07 - 20070042343 - Forward mutation assay based on 5-fluorouracil resistance Disclosed herein is a novel forward mutation assay based on 5-fluorouracil (5-FU) resistance which utilizes a strain of Salmonella typhimurium derived from the Ames strain TA100. More specifically, the invention provides a high throughput alternative to the standard Ames mutation assay for the evaluation of the genotoxicity activity of compounds ... 02/15/07 - 20070037136 - Method of preparing cell cultures from biological specimens for assaying a response to an agent An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly ... 02/15/07 - 20070037135 - System and method for the identification and quantification of a biological sample suspended in a liquid A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at ... 02/15/07 - 20070037134 - Functional coupling of t1rs and t2rs by gi proteins, and cell-based assays for the identification of t1r and t2r modulators The invention resides in part in the discovery that G proteins other than Gα15 couples to T1R and T2R taste receptors, particularly Gi proteins such as Gαi. Related to this discovery, the invention provides cell-based assay methods for identifying compounds that modulate the activity of specific T1R or T2R taste ... 02/15/07 - 20070037133 - Method and apparatus for use of thermally switching proteins in sensing and detecting devices An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance ... 02/08/07 - 20070031821 - Screening molecules with anti-prion activity: kits, methods and screened molecules A kit and a method for identifying compounds having anti-prion activity are provided. The kit comprises a yeast of phenotype [PSI+]; an antibiogram; and a prion curing agent in a sub-effective dose, wherein the yeast has the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene. Compounds and ... 02/08/07 - 20070031820 - Specific bacterial inclusions in bone marrow cells indicate systematic lupus erthematosus, and treatment for lupus A method for diagnosing for the presence of systemic lupus erythematosus (SLE) in a patient is disclosed. In accordance with this method, megakaryocytes present in bone marrow of a person suspected of having SLE are assayed for the presence of internal bacterial structures that specifically stain with an intercalating dye. ... 02/08/07 - 20070031819 - Microfluidic systems for biological and molecular analysis and methods thereof Disclosed herein are systems, components, devices and methods for automated yeast pedigree analysis. Systems, components, devices and methods for analyzing microorganisms, cells, particles and molecules are also disclosed. ... 02/08/07 - 20070031818 - Assay for distinguishing live and dead cells Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is ... 02/08/07 - 20070031817 - Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with ... 02/08/07 - 20070031816 - Mounting device for mounting a retainer means for a biological object and corresponding method for laser micro-dissection To enable contactless laser microdissection in a closed container (10, 11), for example in the form of a Petri dish, it is proposed according to the invention to use a holding device which comprises a receiving portion (4) for arrangement in the container (10, 11) and a holding portion (1) ... 02/08/07 - 20070031815 - Screening method for identifying hsp90 modulators A screening method for identifying and/or analysing Hsp90 inhibitors and/or Hsp90 agonists comprises the steps of contacting a compound with at least two of yeast strains A-E wherein each yeast strain comprises expression vectors from which a pair of binding partners for a yeast two-hybrid assay are expressed. The binding ... 02/08/07 - 20070031814 - Methods of modulating and identifying agents that modulate intracellular calcium Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium. ... 02/08/07 - 20070031813 - Method of examining cell An object of the present invention is to provide a more accurate diagnostic method of a tissue or a cell for carrying out definite diagnosis of cancer, drug resistance test and prognosis. More accurate examination of cancer tissues or cancer cells is enabled by a method of the examination of ... 02/01/07 - 20070026385 - Marker for antidepressant therapy and methods related thereto The present invention relates generally to methods for determining the effectiveness of ongoing antidepressant therapy via analysis of the association of Gsα with components of the plasma membrane or cytoskeleton of cells from peripheral tissues of the depressed individual as well as to methods involved in screening for effective antidepressant ... 02/01/07 - 20070026384 - Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in ... 02/01/07 - 20070026383 - Methods and compositions for extracting membrane proteins The present invention provides methods and compositions for the isolation and use of membrane proteins and other membrane associated molecules (e.g., peptides, carbohydrates, lipids, or combinations thereof). In particular, the present invention provides amphiphilic polymer compositions and methods of using the compositions to solubilize, enrich and isolate components of biological ... 02/01/07 - 20070026382 - Cytometer on a chip An assay technique for label-free, highly parallel, qualitative and quantitative detection of specific cell populations in a sample and for assessing cell functional status, cell-cell interactions and cellular responses to drugs, environmental toxins, bacteria, viruses and other factors that may affect cell function. The technique includes a) creating a first ... 02/01/07 - 20070026381 - Devices and methods for enrichment and alteration of cells and other particles The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present ... 02/01/07 - 20070026380 - System for water removal and solvent evaporation An apparatus and method for separating residual water from a solvent and removing a solvent. The apparatus may be sealed and automated. The method comprises providing a solution comprising solvent and residual water and an analyte. The solution may be passed through a membrane to reduce water content wherein an ... 01/25/07 - 20070020613 - Devices and methods for pharmacokinetic-based cell culture system Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ... 01/25/07 - 20070020612 - Method of measurement of cellular hemoglobin A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the ... 01/25/07 - 20070020611 - Hematology reference control containing an immature granulocyte component A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of ... 01/25/07 - 20070020610 - Methods for ex vivo propagation of adult hepatic stem cells The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. ... 01/25/07 - 20070020609 - Method of determining and prognosing severity of pregnancy toxemia and method of estimating fetus/placenta function under pregnancy toxemia Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for ... 01/25/07 - 20070020608 - Method for the generation of neural progenitor cells A rapid, simple and efficient method for the generation of neural progenitor cells from pluripotent/undifferentiated human blastocyst-derived stem (hBS) cells, neural progenitor cells obtained by the method and further differentiation of these cells into the three neural cell lineages, and the use of the neural progenitor cells and the differentiated ... 01/18/07 - 20070015138 - Methods for identifying agents and conditions that modulate neurogenesis Methods and tools for identifying agents and conditions that modulate neurogenesis are disclosed. The disclosure also relates to methods and tools for identifying populations of neural stem cells suitable for transplantation. ... 01/18/07 - 20070015137 - Microfluid device and method of producing diffusively built gradients A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir, ... 01/18/07 - 20070015136 - Controlling dendritic cell maturation state in the lymphoid tissue equivalent of an artificial immune system The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates ... 01/18/07 - 20070015135 - Methods and computer systems for analyzing high-throughput assays The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the ... 01/18/07 - 20070015134 - Quantitative stabilized cell reference control products and methods The invention relates to quantitative stabilized cell reference control products, their methods of manufacture, and their methods of use. Receptors, antigens, and ligands associated with stabilized cells may be quantitated by the methods of the present invention. Those quantitated stabilized cells may then be used to determine the receptor, antigen, ... 01/18/07 - 20070015133 - Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-β structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides ... 01/18/07 - 20070015132 - System and methods for measuring at least one metabolic rate of a plurality of cells A system and methods for calculating at least one unknown metabolic flux of a plurality of cells. In one embodiment, the method includes the steps of constructing a metabolic network having a plurality of reaction components, the reaction components representing at least glycolysis, reduction of pyruvate to lactate, TCA cycle, ... 01/11/07 - 20070009883 - Low fluorescence assay platforms and related methods for drug discovery One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform ... 01/11/07 - 20070009882 - In vitro platform for screening agents inducing islet cell neogenesis The present invention relates to an in vitro method for screening agents inducing islet cell neogenesis or duct-to-islet cell transdifferentiation, which comprises the steps of: a) expanding in vitro cells of a duct-like structure obtained by inducing cystic formation in cells in or associated with post-natal islets of Langerhans; b) ... 01/04/07 - 20070003922 - Diagnostic biomarkers for neurodevelopmental disorders The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using cytometry and mass spectrometry. The invention further provides methods of using the identified biomarkers to diagnose the presence of a neurodevelomental disorder, including an autism ... 01/04/07 - 20070003921 - Method of grading disease by fourier transform infrared spectroscopy The infrared spectrum of cells or tissues in the frequency range 900cm−1-1750cm−1 is digitally separated by the method of the invention into the component contributions by protein, RNA and DNA. By comparing the relative sizes of the component spectra, relative quantities of these components can be specified. The ratios protein/DNA ... 12/28/06 - 20060292550 - Method for determining fish composition using bioelectrical impedance analysis A method for determining the freshness of fish. The method includes applying electrodes to the fish, passing an electrical current between the electrodes, determining an impedance for tissue of the fish between the electrodes, and correlating the determined impedance with a freshness value to determine the freshness of the fish. ... 12/28/06 - 20060292549 - Psychotropic drug screening device based on long-term photoconductive stimulation of neurons The invention pertains generally to the field of psychotropic drug discovery and neuroscience. More specifically, the invention refers to a device that allows the long-term stimulation of cultured neurons grown on a silicon die, thereby replacing the use of intact animal models. The device consists of a controlled sterile environment ... 12/28/06 - 20060292548 - Trp8, a transient receptor potential channel expressed in taste receptor cells The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion ... 12/28/06 - 20060292547 - Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of ... 12/28/06 - 20060292546 - Herg channel-expressing cell It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high ... 12/28/06 - 20060292545 - Moleculary imprinted polymers for extraction of components from foodstruffs The present invention relates to a novel class of water compatible molecularly imprinted polymers (AquaMIPs) capable of selectively binding target molecules such as riboflavin, or analogues thereof, in water or aqueous media, their synthesis and use thereof in food processing and extraction or separation processes. ... 12/21/06 - 20060286544 - Establishment of a human embryonic stem cell line using mammalian cells Purified preparations of human embryonic stem cells with certain population-specific characteristics are disclosed. This preparation is characterized by the positive expression of the following pluripotent cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); alkaline phosphatase (+), as well as a set of ES cell markers including Oct-4, ... 12/14/06 - 20060281071 - Stearoyl-coa desaturase assay A yeast-based method for identifying an agent that can modulate the activity of a human or mouse stearoyl-CoA desaturase (SCD) is disclosed. Further disclosed are substrate specificities of various human and mouse SCDs, which facilitate the identification of modulators for human and mouse SCDs. ... 12/14/06 - 20060281070 - Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in ... 12/14/06 - 20060281069 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 12/14/06 - 20060281068 - Cytological methods for detecting a disease condition such as malignancy by raman spectroscopic imaging Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment ... 12/14/06 - 20060281067 - Microluminometer chip and method to measure bioluminescence An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the ... 12/07/06 - 20060275745 - Method for optically determining dynamic behaviour of contracting muscle cells The invention refers to a method for optically determining the dynamic behaviour of contracting muscle cells, such as cardiomyocytes in a cell culture, for example, wherein a video sequence of the contracting muscle cells is made using a video camera (3), an image processing unit (4) is used to calculate ... 12/07/06 - 20060275744 - Modified human embryonic stem cells and methods of use to treat neuron-associated disorders The invention is directed to methods for promoting the differentiation and maturation of embryonic and adult stem cells to dopamine neurons by increasing expression of the transcription factors Nurr1 and PitX3 in the stem cells. The invention provides embryonic and adult stem cells expressing Nurr1 and PitX3 from nucleic acid ... 12/07/06 - 20060275743 - Counting, viability assessment, analysis and manipulation chamber A transparent plastic slide has a recessed chamber which receives a transparent plastic cover. The cover has a fluid inlet opening which overlies a recessed center well in the slide. The well has a sloping ramp which extends to a viewing platform which has a surface which is closely spaced ... 11/30/06 - 20060269909 - Screening assay for improvement of epithelial barrier function The present invention relates to the use of an air-liquid interface culture model using asthmatic bronchial epithelial cells, which exhibit impaired epithelial barrier function. It is proposed to use asthmatic epithelial cultures, in the absence of added Th2 or proinflammatory cytokines such as IL-13, as an in vitro model to ... 11/23/06 - 20060263763 - Analyte sensing biointerface Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a ... 11/23/06 - 20060263762 - Cytoskeletal integrity testing as a filter for creating homogeneous samples for further analysis The present invention is generally directed to the integration of cytoskeletal manipulation with genetic and proteomic analysis. “Cytoskeletal manipulation” references any technology that uses either cytoskeletal integrity or cell adhesion to isolate symptomatic cells from asymptomatic cells as a gatekeeping step for genetic and proteomic analysis. As used in the ... 11/23/06 - 20060263761 - Methods and compositions for beryllium-induced disease The present invention provides for methods for detection, diagnosis and prognosis of beryllium-induced disease. In one embodiment, the methods include exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing the Th-1 cytokines produced. Other embodiments include the use of exposing immune cells from subjects suspected ... 11/23/06 - 20060263760 - Screening method of substance with antidepressant action There is provided a rapid and simple screening method of a substance with an antidepressant action. The screening method of a substance with an antidepressant action in accordance with the invention includes a cell preparation step for preparing a cell showing a predetermined electrophysiological response on a given stimulation and ... 11/16/06 - 20060257848 - Methods of preventing or treating cell migration mediated conditions or diseases The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or disease in a subject are also provided. ... 11/16/06 - 20060257847 - Magnetic separation apparatus and methods Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic capture structure may be on the transparent collection wall ... 11/16/06 - 20060257846 - Method of assaying for high performance mammals A method of assaying for animals having a high innate immunity level by assessing the total white blood cell count of the mammal or at least one of the mammal's parents and/or the acute phase protein level of the mammal or at least one of its parents. Alternatively, genetic markers ... 11/16/06 - 20060257845 - Cosmetic treatment of xerosis A method for decreasing the level of skin ashiness in an individual with xerosis and having a Fitzpatrick type 4 or higher score comprising topically applying to the skin of said individual a composition (a) having a cleansing surfactant or mixture of cleansing surfactants in quantity sufficient to cleanse the ... 11/09/06 - 20060252027 - Cellulosic-based resistance domain for an analyte sensor The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain. ... 11/02/06 - 20060246419 - Layered support sheet for high-yield spot cutting from gels or membranes The excision of sample spots from a gel or membrane by pressing a cutting tool terminating in a hollow cylinder against the gel or membrane supported on a rigid surface is made more reliable by interposing a relatively pliable, intermediate layer on the side of the surface facing the gel ... 11/02/06 - 20060246418 - Method for screening compounds & uses therefor In accordance with the present invention, it has been discovered that glucose and incretin hormones promote pancreatic islet cell survival via the calcium and cAMP dependent induction, respectively, of the transcription factor CREB. Specifically, a signaling module has been identified which mediates cooperative effects of calcium and cAMP on islet ... 11/02/06 - 20060246417 - System for functional analysis of polypeptides The present application discloses a polypeptide assay system that includes a non-mammalian cell in a non-mammalian cell culture medium expressing a heterologous polypeptide that is either displayed on its cell surface such that the polypeptide is the predominant polypeptide displayed on the cell surface or the polypeptide is secreted, and ... 11/02/06 - 20060246416 - On-chip bioassay method and kit The present invention provides an on-chip bioassay system which reduces preoperations including culture, and is highly versatile and capable of conducting high throughput analyses. A microfluidic chip for introducing a cell is fixed on the undersurface of a microporous chip composed of a substrate through which a plurality of micropores ... 11/02/06 - 20060246415 - Methods for detection of breast cancer The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without ... 10/26/06 - 20060240404 - Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle ... 10/26/06 - 20060240403 - Tape magazine for a hand-held device The present invention concerns a tape magazine especially for a hand-held device for analysing a body fluid with a test tape that can be unwound from a storage unit and wound onto a waste unit where the waste unit can be driven in order to wind forward the test tape. ... 10/26/06 - 20060240402 - Marine invertebrate gametes and embryos as an assay system for therapeutic screening The invention provides methods of using of marine invertebrate gametes and preparations thereof for drug discovery and therapeutic screening. ... 10/26/06 - 20060240401 - Handheld raman body fluid analyzer Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface ... 10/26/06 - 20060240400 - High-density cell array board, process for producing the same and method of using the same Culture substrates, cell arrays, automatic chemical dispensers and assay systems necessary for conveniently assaying multiple chemicals such as drugs and toxic agents are provided. Herein used is a substrate for a high-density cell array characterized in that it has a surface comprising an ordered array of discrete microdomains coated with ... 10/19/06 - 20060234207 - Device for evaluating in vitro cell migration under flow conditions, and methods of use thereof The current invention is directed towards a device that useful for studying cell migration. It is preferred that the device is configured to study stem cell, particularly hematopoetic stem/precursor cell homing. The device allows for detailed analysis of the various phases of the multiphase homing process. There are also provided ... 10/19/06 - 20060234206 - Fluorescent probes for biological studies and methods monitoring protein-protein interactions. ... 10/19/06 - 20060234205 - In vitro test system for predicting patient tolerability of therapeutic agents Methods for predicting patient tolerability to therapeutic agents, such as cytokines, lymphokines and immunotoxins, are disclosed. The methods utilize an in vitro model of vascular leak syndrome (VLS) to assess the effect of the agent in question on the permeability of large proteins across confluent monolayers of endothelial cells (EC). ... 10/12/06 - 20060228695 - Predicting hepatotoxicity using cell based assays Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, ... 10/12/06 - 20060228694 - Methods to individualize combination therapy Compositions which comprise delivery vehicles having stably associated therewith predetermined, patient-specific combinations of two or more agents, such as antineoplastic agents, are useful in achieving optimal therapeutic effects on a patient-by-patient basis when combinations of drugs are administered. ... 10/05/06 - 20060223051 - System and method for performing g protein coupled receptor (gpcr) cell assays using waveguide-grating sensors The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells ... 09/28/06 - 20060216690 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/28/06 - 20060216689 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/28/06 - 20060216688 - Ion channel assay methods A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a ... 09/21/06 - 20060210964 - Prevention and treatment of amyloid-associated disorders The present invention provides assays to identify compounds that affect microglial cell activation, and specifically assays to identify compounds that affect secretion of cytokines from these microglial cells by modulating PGE2-mediated activity. The assays of the invention include assays for testing microglial cell activation by contacting microglia with compounds that ... 09/21/06 - 20060210963 - Induction of a beta cell differentiation in human cells The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are ... 09/21/06 - 20060210962 - Cell observation device and cell observation method The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a ... 09/21/06 - 20060210961 - Method and system for analysing a liquid sample discharging reagents located in the reaction loop (42). The present invention also relates to a system for analyzing a liquid sample. ... 09/14/06 - 20060204953 - Method and apparatus for automated analysis of biological specimen Apparatus and methods for automatic classification of cells in biological samples is disclosed. Aggregation parameters of identified objects are calculated using relative spatial positions of the objects, and the aggregation parameters are used in the classification. Centres of cells may be located using an edge detector and parameterisation across at ... 09/14/06 - 20060204952 - Technique for measuring cell-membrane properties in cultured cells grown on biomaterials in an ussing chamber The present invention is directed to a system and method which measures transcellular parameters in which cells are cultured in a monolayer on a biomaterial. The parameters measured are indicative of in vivo values such as cell-cell and cell-matrix adhesion parameters. ... 09/14/06 - 20060204951 - Platelet biomarkers for the detection of disease The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other ... 09/07/06 - 20060199173 - Device and method for characterizing spheroids The present invention relates to a device and a method for characterizing spheroids. The to-be-characterized spheroid is introduced into a tube of an electrically insulating material and with an inner diameter which is smaller than the diameter of the to-be-characterized spheroid in such a manner that the latter is in ... 09/07/06 - 20060199172 - Laminated cell culture containing hepatocytes and method for detecting endocrine-like substance A laminated cell culture obtained by lamination of a cell layer containing hepatocytes and a cell layer containing one or more kinds of cells selected from the group consisting of vascular endothelial cells, vascular smooth muscle cells, adipocytes, hemocytes, and macrophages; a laminated cell culture system obtained by lamination of ... 09/07/06 - 20060199171 - Assays for tert promoter modulatory agents Methods and compositions for assaying an agent for TERT promoter modulatory activity are provided. In the subject methods, an agent is contacted with a normal cell under assay conditions that provide for a detectable phenotype, e.g., cell death, upon modulation of TERT promoter transcription control activity. Also provided are compositions, ... 09/07/06 - 20060199170 - Ferromagnetic cell and tissue culture microcarriers A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also provided is a method for creating batches of microcarriers which have inserted within them magnetite (Fe3O4) in the presence of collagen, thus creating a ... 09/07/06 - 20060199169 - Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation unit for performing the production of the tissue column ... 09/07/06 - 20060199168 - Cell recovery The present invention relates to apparatus for recovering selected particles having predetermined properties from a number of particles. The apparatus includes a stimulation system, a detection system, a retriever and a control system. In use, the control system is adapted to activate the stimulation system to attempt to stimulate one ... 08/31/06 - 20060194194 - Diagnostic measurement of disease Diagnostic systems and methods that can be used to perform direct tests on immune system or other proliferative cells, which are capable of identifying abnormal cell function associate with disease without use of labeled reagents; that also permit, but do not require provision of an autoantigen; that are capable of ... 08/31/06 - 20060194193 - Biological sample culturing and observation system, incubator, supplying device, and culture vessel The present invention provides a biological sample culturing and observation system which includes: an incubator in which a biological samples are housed, and whose interior is maintained in a culturing environment satisfying predetermined conditions, and the interior is isolated from the outside; an observation optical system that from outside the ... 08/24/06 - 20060188870 - Identification of active sites in enzymes A method for determining the location of the active site of an enzyme is provided. The method comprising: determining a location of a reference point inside a functional unit of the enzyme; determining a limiting distance from the reference point; and identifying one or more molecular surface portions within the ... 08/24/06 - 20060188869 - Method and apparatus for uv imaging A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with ... 08/24/06 - 20060188868 - Direct detection method for products of cellular metabolism using tof-sims A rapid and efficient method for novel biological substance screening by surface analysis has been developed using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). This method relies on the surface screening of an array of micro-organisms grown on porous membranes, which had previously been in contact with a solid growth medium. ... 08/17/06 - 20060183105 - Human brain-derived tissue-specific potassium channel A novel human brain-derived potassium channel polypeptide is described which is developmentally regulated and tissue-specific to differentiated neurons. A full length cDNA which encodes the novel potassium channel polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the human brain potassium channel ... 08/17/06 - 20060183104 - Cellular models of neuron-associated disorders and uses thereof The present invention describes two new cell lines derived from embryonic stem cells and useful for analyzing and studying neuron-associated disorders. The present invention further relates to methods of analyzing stem cell differentiation, and methods of identifying new therapies for neuron-associated diseases ... 08/10/06 - 20060177816 - Cellular rhogtpase activation assay The invention relates to a cellular RhoGTPase activation assay based on the determination of changes in the actin cytoskeleton (actin cytoskeletal rearrangement assay); to the recombinant cell lines used to carry out this assay; to the constructs required to produce these cell lines; to the use of these recombinant cell ... 08/10/06 - 20060177815 - Dielectrophoretic particle sorter Provided are methods, devices and systems that utilize dielectrophoretic forces to separate a target species from a plurality of species in a sample. ... 08/10/06 - 20060177814 - Systemic lupus erythematosus This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose ... 08/10/06 - 20060177813 - Novel high-throughput screening method of drug for bioactive protein The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have strenuously studied to solve the matters above ... 08/10/06 - 20060177812 - Method and device for manipulating samples The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (2) for punching holes (34) in sample carriers (4) and at least one further needle (3) for punching samples out of preparations (5), wherein a device for detecting the ... 08/03/06 - 20060172280 - System for monitoring cell motility in real-time The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper ... 08/03/06 - 20060172279 - Cell-based sensing: biological transduction of chemical stimuli to electrical signals (nose-on-a-chip) Methods and compositions for the reliable detection of chemical stimuli using a “nose-on-a-chip” are presented. The invention uses cells sensitive to chemical stimuli and detects and processes the signals given by the cells upon contact with chemical stimuli. ... 08/03/06 - 20060172278 - Target activated microtransfer A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a ... 08/03/06 - 20060172277 - Method for determining the influence of a test substance on the heart activity of a vertebrate In a method for determining the influence of a test substance on the heart activity of a vertebrate the following steps are performed: a) preparation of a culture of spontaneously active heart cells of the vertebrate, b) extracellular measurement of electrophysiological data of the heart cells from step a), c) ... 07/27/06 - 20060166185 - System for and method of patch clamp analysis A system and method for automated patch clamp analysis of biological tissue such as cellular membrane. A biological membrane is applied to a porous semiconductor substrate, and laser energy is imparted thereon. Voltage clamped electrodes detect current across the membrane to indicate ion channel activity. ... 07/27/06 - 20060166184 - Apparatus for cell reaction examination and method of cell reaction examination Disclosed herein are an inspection apparatus for cell reaction by a device for liquid processor, which can set a fluid running route to a cell reaction site required according to the kind of an inspection of a cell reaction to be conducted with a great degree of freedom, and an ... 07/27/06 - 20060166183 - Preparation of coatings through plasma polymerization The invention provides a method to prepare at least part of at least one surface of a substrate comprising; depositing on said surface at least one plasma monomer wherein during deposition of said monomer, means are provided which move the monomer source across a surface to be treated to manufacture ... 07/20/06 - 20060160066 - Cellular microarrays for screening differentiation factors Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel. ... 07/20/06 - 20060160065 - Method for classifying plant embryos using raman spectroscopy A three-step method for classifying plant embryo quality using Raman spectroscopy is provided. First, a classification model is developed based on Raman spectral data of reference samples of plant embryos or any portions of plant embryos of known embryo quality. The embryo quality may be known based on a comparison ... 07/20/06 - 20060160064 - Devices and methods for removing target agents from a sample The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample. ... 07/20/06 - 20060160063 - Method of screening physilogically active substance The present invention relates to a method of screening a physiologically active substance, comprising the steps of (1) contacting a transformed yeast with a test sample, wherein the transformed yeast is capable of expressing a heterogeneous protein, and shows a change in a growing state in an expression state of ... 07/13/06 - 20060154236 - Computer-assisted analysis The present invention provides methods and systems for automated morphological analysis of cells also known as phenotypic screening. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen or in the screening for agents with a particular mechanism of action. Agents which cause ... 07/13/06 - 20060154235 - Human hepatocyte-like cells and uses thereof The present invention provides modified methods of producing human hepatocyte-like cells which exhibit phenotypes more similar to those of human hepatocytes. The present invention also provides the human hepatocyte-like cells and uses thereof. The methods of the present invention comprises a prolonged incubation period and addition of dexamethasone to the ... 07/13/06 - 20060154234 - Standard Disclosed is a reference standard for a detectable entity, the reference standard comprising a support medium, such as an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a biological, such ... 07/13/06 - 20060154233 - Method and device for manipulating individual small objects A method for individually moving small objects, such as cells, from one location to another as well as a device for implementing the method is disclosed. A small object such as a cell is isolated at some initial location and moved to some destination location by the movement of the ... 07/06/06 - 20060147904 - Use of resveratrol to regulate expression of apolipoprotein a1 Described are new methods for promoting the expression of apolipoprotein A1 (APO A1) for increasing levels of HDL, and assays for screening and identifying compounds for regulating expression of the APO A1 protein. ... 07/06/06 - 20060147903 - In vitro organ modeling with cell culture tool A method of culturing different cell types from a single organ in a cell culture tool having more than one well includes depositing the different cell types from the single organ in separate wells, culturing the different cell types in the separate wells and filling the cell culture tool to ... 07/06/06 - 20060147902 - Yeast screens for treatment of human disease Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein ... 07/06/06 - 20060147901 - Devices and methods to image objects by time delay integration Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDI technology into ... 07/06/06 - 20060147900 - Compositions and methods for determining oocyte development potential The present invention relates to the field of reproduction (e.g., human reproduction). In particular, the present invention provides markers (e.g., pentraxin 3 and Annexin A6), and methods of using the same to determine oocyte development potential. The present invention also provides compositions and methods for modifying oocyte development potential and ... 07/06/06 - 20060147899 - Multicellular metabolic models and methods The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plu |