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Chemistry: Molecular Biology And Microbiology > Maintaining Blood Or Sperm In A Physiologically Active State Or Compositions Thereof Or Therefor Or Methods Of In Vitro Blood Cell Separation Or Treatment

Maintaining Blood Or Sperm In A Physiologically Active State Or Compositions Thereof Or Therefor Or Methods Of In Vitro Blood Cell Separation Or Treatment

Maintaining Blood Or Sperm In A Physiologically Active State Or Compositions Thereof Or Therefor Or Methods Of In Vitro Blood Cell Separation Or Treatment patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

05/17/07 - 20070111191 - Storage of blood
A ribose-related compound is added to whole blood or packed red cells which have suboptimal function as measured by decreased levels of 2,3-DPG in order to rejuvenate the red blood cells to normal function as seen by raised levels of 2,3-DPG. Two representative ribose-related compounds are D-ribose and inosine. ...

05/03/07 - 20070099172 - Methods and device for freezing and thawing biological samples
A method for changing the temperature of a sample from an initial temperature via an intermediate temperature to a final temperature, one of the initial and final temperatures being above the freezing point of the sample and the other being below the freezing point is provided. The method is for ...

05/03/07 - 20070099171 - Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection ...

05/03/07 - 20070099170 - Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
Methods are provided for treatment and storage of blood and blood products using at least endogenous alloxazines and acetate. Methods include adding a blood component additive solution comprising at least an endogenous alloxazine and acetate to a fluid comprising at least one collected blood component. ...

04/26/07 - 20070092860 - Sperm suspensions for use in insemination
The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection ...

04/19/07 - 20070087324 - Method of providing readily available cellular material derived from peripheral blood
Process for preparing a peripheral blood cell composition in a TVEMF-bioreactor. ...

04/19/07 - 20070087323 - Sampling system
A device for collecting and storing a biological sample for subsequent analysis, comprising tamper-evident storage means for storing said sample, said storage means being suitable for digestion together with said biological sample. ...

04/19/07 - 20070087322 - Method of preserving early embryos of experimental animals by vitrification
This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol and ...

04/05/07 - 20070077546 - Concentration techniques in chromatographic separation
Apparatus and methods are disclosed for concentrating one or more components in a fluid effluent, which comprises fractions comprising separated components of interest. The fluid effluent is passed through a concentration device comprising a hollow element comprising a wall at least a portion of which is porous wherein the hollow ...

04/05/07 - 20070077545 - Sperm protective polypeptides and uses thereof
The present invention relates to polypeptides capable of binding chaperone receptors, composition and methods for protecting, restoring, or improving the physiological properties of sperm cells. More particularly, the invention relates to protection of the motility, survival, fertility capability, resistance to cooling, freezing, and thawing of sperm cells put in contact ...

03/29/07 - 20070072166 - Semen preservation
The present invention provides a method for determining the suitability of a sample of mammalian semen for cooling and/or cryopreservation or storage, which comprises: (a) providing said sample of semen; (b) determining the level of a hydrophobic stimulator of 11β-HSD activity in said sample; and (c) assessing, from the level ...

03/08/07 - 20070054258 - Method of removing mucus and cell treatment solution and preservative solution used therefor
Mucus can be removed from cell surfaces so as to enable immunochemical labeling by bringing a cell treatment solution containing cysteine and/or a compound derived therefrom in an amount of 5 mass % or more into contact with a cell specimen containing mucus producing cells, such as uterine cervix cells. ...

02/22/07 - 20070042342 - Separation systems of frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
Devices, compositions, and methods for handling, separating, packaging, and utilization of spermatozoa (1) that can be derived from previously frozen sperm samples collected from a male mammal. Specifically, techniques to uniformly stain (2) spermatozoal DNA even when derived from previously frozen sperm and separation techniques to separate and isolate spermatozoa ...

02/22/07 - 20070042341 - Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpopulations and in cryopreservation, culture and transplantation of cells
The invention discloses a biodegradable particle-cell composition having at least one biodegradable particle, at least one receptive group covalently linked thereto, and a cell anchored thereto. The particle can be polylactide, a polylactide-lysine copolymer, polylactide-lysine-polyethylene glycol copolymer, starch, or collagen. The receptive group can be an antibody, a fragment of ...

02/22/07 - 20070042340 - Method and apparatus for protecting biological specimens
A biological specimen is preserved by surrounding the biological specimen with a protective enclosing structure. The protective enclosing structure reacts with corrosive components in the surrounding atmosphere or environment to reduce their degradative effect and also protects the preparations from bacterial and fungal growth. ...

02/22/07 - 20070042339 - Preservation of biomaterials with transported preservation agents
Biomaterial are preserved by exposing them to a preservation agent having preservation properties. The biomaterial has at least one transporter that allows uptake of the preservation agent into the biomaterial for loading the biomaterial with the preservation agent to an intracellular concentration sufficient for preserving the biomaterial. The preservation agent ...

02/22/07 - 20070042338 - Method for storing tumor cells
The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of −196° C. to 37° C., characterized in that the liposomes comprise one or more sterols and that the cells ...

02/15/07 - 20070037132 - Separation of platelets from fluid suspensions
A device for separating platelets from a fluid suspension comprises a mixing chamber operable to receive and mix fluid suspensions and an aggregating agent to form platelet aggregates and residual fluid components. A filter can be configured to be in fluid communication with the mixing chamber and can be further ...

02/08/07 - 20070031812 - Processing of platelet-containing biological fluids
Platelet resuspension solutions, platelet storage solutions and systems for processing platelet-containing biological fluids are disclosed, wherein a platelet resuspension solution comprises an aqueous solution having a pH in the range of from about 4 to about 6: dextrose; and citrate; wherein the solution is substantially free of adenine, and wherein ...

02/08/07 - 20070031811 - Methods of inducing a t cell mediated immune response by administering antigen presenting b cells
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B cells can be obtained from peripheral blood in large numbers. These cells can be activated in vitro by coculture ...

02/01/07 - 20070026379 - Collection systems for cytometer sorting of sperm
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and ...

02/01/07 - 20070026378 - Methods and apparatus for reducing protein content in sperm cell extenders
The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein content in a sperm cell extender; techniques for reducing protein content in a cryoprotectant-containing B fraction of a sperm cell ...

02/01/07 - 20070026377 - Methods for preserving nucleated mammalian cells
Methods and compositions are provided for increasing the survival of nucleated mammalian cells following drying and rehydration. The methods include introducing a disaccharide such as trehalose into said cells, optionally including heat shock proteins, apoptosis inhibitors, and arbutin, drying said cells, and rehydrating them. The invention further provides nucleated mammalian ...

01/25/07 - 20070020607 - Methods for the storage and deglycerolization of red blood cells
The present invention relates to improved methods for the anticoagulation of whole blood and the subsequent refrigerated storage of red blood cells and to improved methods for removing glycerol from frozen-thawed red blood cells. ...

12/28/06 - 20060292544 - Systems, methods, compositions and solutions for perfusing an organ
The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ. ...

11/30/06 - 20060269908 - Cryopreservation of primate embryonic stem cells
Primate embryonic stem cells are cryopreserved by resuspension in a freezing medium and slow cooling at a controlled rate. In some embodiments, prior to the controlled freezing step, the suspension of cells is cooled to a temperature just below freezing, and ice crystal formation is induced. The cryopreserved cell aggregates ...

11/30/06 - 20060269907 - Decontamination of biological fluids using diphenylpyrilium compounds
The present invention affords means for decontaminating biological fluids such as blood and blood components. The method involves contacting a biological fluid with a diphenylpyrilium compound, and irradiating the mixture with red light. The method is a potent and effective means for eliminating or diminishing active pathogens such as viruses, ...

11/23/06 - 20060263759 - Dried blood plasma product
The present invention provides a fluidized bed dried blood plasma. ...

11/16/06 - 20060257844 - Disinfection of biological fluids using asymmetric cyanine dyes
Asymmetric cyanine dyes of Formula I bind nucleic acid but not red blood cell membrane, and function as photosensitizers when rigidly bound but not when free in solution. Unbound dye thus causes minimal oxidative damage. The dyes do not substantially accumulate in red blood cells, thereby minimizing hemolysis due to ...

11/09/06 - 20060252026 - Cryopreservation method for bivalve oocytes
A method for cryopreserving bivalve oocytes, particularly those of Pacific oysters, by preparing a solution of a cryoprotectant in water, combining this with the oocytes, carrying out a first cooling step to a temperature of about −4° C. to −20° C., and carrying out a second cooling step to a ...

11/09/06 - 20060252025 - Low temperature deparaffinization
Methods and apparatuses for gently removing embedding media from biological samples at temperatures below the embedding medium melting point with liquid composition using batch methods or automated instruments prior to immunohistochemical (IHC), in situ hybridization (ISH) or other special staining or histochemical or cytochemical manipulations. ...

11/02/06 - 20060246414 - Method for microdrop vitrification of cells
The present invention relates to a method for microdrop vitrification of cells comprising providing cells, culturing the cells in a culture medium containing cryoprotectants for a short period, forming a microdrop from the culture medium containing the cells, and contacting the microdrop with liquid nitrogen to obtain a glass-like bead. ...

10/05/06 - 20060223050 - Therapeutic platelets and methods
The invention provides methods for loading a preservative into blood platelets comprising providing a preservative solution having a preservative, water and protein, and loading blood platelets with the preservative solution to produce preservative-loaded blood platelets having the preservative solution generally including higher glass transition temperatures than glass transition temperatures for ...

09/28/06 - 20060216687 - Reconstitutable dried blood products
The invention provides a process for the preparation of a dried particulate blood product the particles whereof comprise anuclear blood cells in a protective agent, said process comprising: obtaining a blood sample from a mammalian subject; adding an anticoagulant to said sample; concentrating the cells of said sample; recovering a ...

09/21/06 - 20060210960 - Method for processing and preserving collagen-based tissues for transplantation
A method for processing and preserving an acellular collagen-based tissue matrix for transplantation is disclosed. The method includes the steps of processing biological tissues with a stabilizing solution to reduce procurement damage, treatment with a processing solution to remove cells, treatment with a cryoprotectant solution followed by freezing, drying, storage ...

08/31/06 - 20060194192 - Stabilization of cells and biological specimens for analysis
Compositions and methods for stabilizing rare cells in blood specimens, preserving the quality of blood specimens, and also serving as cell fixatives are disclosed which minimize losses of target cells (for example, circulating tumor cells) and formation of debris and aggregates from target cells, non-target cells and plasma components, thereby ...

08/31/06 - 20060194191 - Processing method for the long-term stabilization of biological red blood cell volume
The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention comprises contacting the sample with a solution comprising a membrane-fixation ...

08/24/06 - 20060188867 - Method of cryopreserving cells and tissues by liposomal delivery of sugars to enhance post-thaw viability
A method for cryopreserving cells entails the liposomal delivery of intracellular sugar(s), such as trehalose, sucrose, raffinose, stachyose, and combinations thereof, into cells and tissues, such as red blood cells, for enhancing post-thaw viability. This method enables rapid and easy delivery of protective molecules into cells which thus greatly simplifies ...

08/24/06 - 20060188866 - Diaminophenothiazine compositions and uses thereof
Cell senescence is delayed by contacting a cell specifically determined to be in need of delayed cell senescence with an effective amount of a diaminophenothiazine. ...

08/17/06 - 20060183103 - Method for enriching adherent monocyte populations
The present invention provides methods and apparatus for the rapid and efficient collection and purification of activated monocytes. The methods and apparatus of the present invention provide means for effecting the collection and purification in an aseptic environment. The method involves filtering a blood component mixture through a monocyte-adhering filter; ...

08/10/06 - 20060177811 - Composition for preserving platelets and method of using the same
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, ...

07/13/06 - 20060154232 - Stack of supports, in particular for cryopreservation of biological samples
Substrates (100) are described for receiving a plurality of samples, especially for the preservation of biological samples at cryotemperatures comprising a plurality of substrate plates (11, 12, 13) arranged on top of one another as a stack (10) and comprising an anchoring axis (20) to which the substrate plates (11, ...

07/06/06 - 20060147895 - System, chamber, and method for fractionation, elutriation, and decontamination of fluids containing cellular components
A chamber, system, and method for separating a selected component from a fluid are provided. The chamber is capable of rotating about the central axis of a centrifuge device and includes a radially-extending duct having an optimized variable cross-sectional area that decreases in relation to the outward radial distance from ...

07/06/06 - 20060147894 - Jacketed vessel for holding semen for sex biasing mammals through artificial insemination and systems and methods for enhancing the probability of sex biasing using the same
A jacketed container for holding a semen sample from a mammalian donor at a predetermined temperature for a predetermined period of time prior to incubation to enhance the probability of obtaining offspring of a selected sex through artificial insemination is disclosed. In one embodiment, the semen sample is collected and ...

06/22/06 - 20060134597 - Apparatus and method for rapid separation of cells without using density gradient and antibodies
A method and an apparatus for rapid cell separation without using density gradient and antibody but using a column packed with resin particles. The interactions between cell surfaces and resin particles resulting in the different retention time of different cells in the column contribute to the separation of the specific ...

06/22/06 - 20060134596 - Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method
An improved method for vitrification of biological cells, especially blastocyst-derived stem cells (BS cells). The method is very mild for the cells that remain viable after they have been thawed. The method comprises, i) transfer of the cells to a first solution (solution A), ii) optionally incubation of the cells ...

06/22/06 - 20060134595 - Polymer affinity matrix, a method for the production and use thereof
A polymer affinity matrix for the binding of one or more substances in a fluid for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating, or reducing undesired activation of components in said fluid is described, as ...

06/15/06 - 20060127876 - Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor the tissue is trimmed and thereafter soaked in a ...

06/15/06 - 20060127875 - Device for separation of platelets from whole blood
A method is described for separating, retrieving and concentrating platelets from whole blood relying on aggregation of the platelets followed by filtration. This method eliminates the need of a centrifuge for separating said cells from blood. To obtain cellular concentrates of platelets, blood is mixed with compatible agents that will ...

06/15/06 - 20060127874 - Plasma preparation or serum preparation and process for producing the same
The present invention relates to a plasma product or a serum product with an extremely low risk of viral contamination and a method for producing the same. Before treating plasma or serum to be used as a raw material for producing a plasma product or a serum product using a ...

06/15/06 - 20060127873 - Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive ...

06/08/06 - 20060121440 - Low pressure sperm cell separation system
A sperm cell process system providing to generate sperm cell insemination samples having controlled sperm cell fertility characteristics of sperm cells. ...

05/18/06 - 20060105317 - Method and solutions for cryopreserving oocytes, especially fresh human oocytes
In a method for cryopreserving fresh human oocytes, freezing and thawing solutions are used, which solutions include 1,2 propanediol (PROH) and sucrose at a concentration of at least 0.3M. The oocytes are exposed for 13-15 minutes to a solution including 1.5M PROH and 0.3M sucrose before starting the freezing process. ...

05/04/06 - 20060093999 - Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix ...

04/27/06 - 20060088814 - Enhanced cell preservative solution and methods for using same
The present invention relates to an aqueous alcohol buffer solution for substantially ambient, in vitro preservation of mammalian cells for a selected duration. ...

04/27/06 - 20060088813 - Glyoxal/zinc fixative
This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention comprises glyoxal (pyruvate aldehyde) and zinc sulfate and permits staining of biological samples without use of toxic compounds, such as formaldehyde and mercury-containing compounds. ...

04/13/06 - 20060078872 - Cell-preservation liquid
A cell-preservation liquid containing at least a saccharide, sodium ion, and potassium ion, which is characterized in that the molar concentration of the contained sodium ion is equal to or more than that of the potassium ion is provided. The preservation liquid enables not only cryopreservation but also cold preservation, ...

04/06/06 - 20060073467 - Biocompatible polymer and filter for selectively eliminating leucocytes using the same
It is intended to provide a polymer which is scarcely eluted, has a high biocompatibility and is useful in a filter for selectively eliminating leucocytes. It is also intended to provide a filter for selectively eliminating leucocytes, a filtration apparatus for selectively eliminating leucocytes and a system for selectively eliminating ...

03/30/06 - 20060068369 - Blood component separation method and apparatus
An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is ...

03/09/06 - 20060051732 - Ambient stored blood plasma expanders
A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, ...

03/09/06 - 20060051731 - Processes for preparing lyophilized platelets
The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, and kits comprising those freeze-dried platelets. The freeze-dried platelets of the invention have similar characteristics to fresh platelets, have an exceptionally long shelf-life, and can be used for all ...

02/09/06 - 20060029923 - Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane
A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or ...

01/26/06 - 20060019234 - Modern blood banking employing improved cell preservation composition
An improved anticoagulant is based on a higher level of citric acid than is usual (at least about 0.2% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino acid citrate ...

01/19/06 - 20060014134 - Low-temperature storage of suspension samples in suspended sample chambers
A cryostorage device (100) is described that includes at least one data storage device (200) and at least one sample receptacle device (300) with at least one sample chamber (301, 302, etc.) for the uptake of a suspension sample, the at least one sample chamber (301, 302, etc.) being connected ...

01/12/06 - 20060008792 - Process for improvement of virus-safe biological fluids
The present invention relates to a process of disinfecting biological materials. In particular, a novel process is provided for removing detergent and/or solvent added to biological materials for the inactivation of viral contaminants. Safe, efficient, and economical methods for removing virucidal agents such as solvent-detergent from virus-inactivated pooled plasma by ...

01/12/06 - 20060008791 - Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method
The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, ...

01/05/06 - 20060003309 - Method of frozen donor egg banking
A method is provided for a frozen egg bank comprising a) retrieving egg cells from an egg donor; b) cryopreserving said eggs in a cryopreservation solution; c) quarantining said eggs; and d) testing the egg donor for an infectious agent following a quarantine period of time. Optionally the method may ...

01/05/06 - 20060003308 - Electrocompetent cells prepackaged for electroporation
Electrocompetent cells are prepackaged in a sterilized cuvette, and the cell contents frozen, such that electroporation can be performed simply by first thawing the cuvette contents, then electrically connecting the cuvette to a power source suitable for electroporation. The cuvette contains, in addition to the cells, a suspending medium, and ...

12/29/05 - 20050287516 - Medium and method for preserving platelets, red blood cells, and other non-nucleus cells and platelets-containing composition
The present invention provides a platelet-containing composition prepared by contacting platelets with a medium for preserving. The medium comprises anticoagulant, cryoprecipitate and thrombin. The present invention also provides a method for long-term preservation of platelets, comprising the steps of: (a) adding anticoagulants, cryoprecipitate, thrombin in normal saline; (b) adding a ...

12/29/05 - 20050287515 - Removal of bacterial dna from therapeutic fluid formulations
This invention discloses methods and devices useful for eliminating or reducing the adverse effects associated with the use of a variety of therapeutic fluids. It is proposed herein that the source of such side effects (e.g. fever and septic shock) is the oligonucleotides present in the fluid and that using ...

12/29/05 - 20050287514 - Compositions and methods useful for hcv infection
The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present invention also provides methods for assaying HCV production and methods for evaluating ...

12/29/05 - 20050287513 - Method for preserving intracellular molecular detail
A process and composition is described that allows the operator to fix and preserve tissue culture grown cells such that their intracellular molecular detail is retained for up to four years. This enables increased reproducibility of staining for antigens and small molecule targets for use in the areas of basic ...

12/22/05 - 20050282144 - Method and system for removing solutes from a fluid using magnetically conditioned coagulation
A method for removing a solute from a fluid using magnetically conditioned coagulation includes magnetically conditioning the fluid by applying a conditioning magnetic field to enhance the precipitation of solute particles for coagulation; adding a coagulant to the fluid before, during, or after application of the conditioning magnetic field to ...

12/22/05 - 20050282143 - Use of visible light at wavelengths of 500 nm and higher to pathogen reduce blood and blood components
This invention is directed towards a method of using visible light at wavelengths of at least 500 nm and above in combination with a sensitizer having a flavin moiety to reduce any pathogens that may be contained in blood and blood components. By exposing the blood and blood components to ...

12/15/05 - 20050277108 - Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation
There are provided methods and compositions for the storage of red blood cells. The compositions are metabolic supplements that are preferably added to refrigerated red blood cells suspended in an additive solution. Red blood cells are preferably stored under conditions of oxygen-depletion. Metabolic compositions comprises pyruvate, inosine, adenine, and optionally ...

12/15/05 - 20050277107 - Systems and methods for cell preservation
The present invention generally relates to devices and methods for the preservation of cells using drying, freezing, and other related techniques. In one set of embodiments, the invention allows for the preservation of cells in a dried state. In another set of embodiments, the invention allows for the preservation of ...

12/01/05 - 20050266392 - Central control system of specimen preservation devices
An object is to provide electrical locks in a plurality of culture devices represented by incubators and in a plurality of preservation devices represented by chemical coolers, in order to build a system based on the idea of one chamber one donor; and to provide a central control system wherein ...

11/10/05 - 20050250088 - Cryopreservation media
A sodium-depleted media that does not employ PBS as the buffer for use in the cryopreservation of oocytes is provided. Also provided are methods of using said media and oocytes cryopreserved therewith. ...

11/03/05 - 20050244805 - Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
Sperm cell suspensions comprising a motility inhibitor are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduring the various process steps typically associated with the sorting of sperm cells into gender enriched populations, thereby resulting in post-sort compositions with an increased number of viable ...

10/27/05 - 20050239042 - Novel cellular compositions and methods for their preparation
The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells ...

10/27/05 - 20050239041 - Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products
Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce ...

10/27/05 - 20050239040 - In vitro fertilisation
The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two ...

10/20/05 - 20050233302 - Compositions and methods for the storage of red blood cells
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and ...

10/20/05 - 20050233301 - Cryopreservation of haptenized tumor cells
A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells ...

10/20/05 - 20050233300 - Method for preserving sperm
A method for preserving spermatozoa (sperm) by air-drying. A semen sample is received and the sperm are separated from contaminants in the semen sample. The sperm may be separated from the semen sample by layering the semen sample onto a two-layer discontinuous percoll layer followed by centrifugation or by centrifuging ...

10/13/05 - 20050227219 - Method for suppression or reversing of cellular aging
A method is provided for growing young cells that reduces and/or reverses age-related processes that would otherwise occur in those cells, and also compositions for growing cells in such a method. ...

09/29/05 - 20050214733 - Sperm suspensions for use in insemination
Processes of storing sorted and unsorted spermatozoa, in the form of a sperm dispersion, having reduced motility relative to endogenous ejaculated sperm are disclosed. The immotile spermatozoa of the dispersion tend to have a greater capacity for enduring the rigors associated with storage, transportation, and fertilization procedures. Processes for providing ...

09/22/05 - 20050208462 - Additive solution for blood preservation
There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or N4HCl. Composition are preferably used with oxygen-depletion refrigerated storage of red blood cells and may optionally be employed with nutrient supplements extending the ...

09/15/05 - 20050202395 - Methods for uniformly treating biological samples with electromagnetic radiation
Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate ...

08/25/05 - 20050186553 - Systems and methods for removing viral agents from blood
Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and ...

08/11/05 - 20050175978 - Methods and devices for mecroencapsulation of cells
Devices for the microencapsulation of cells include a first chamber for containing a cell-solution suspension. A plate covers one end of the first chamber. The plate has a plurality of apertures. A second chamber is provided for receiving encapsulated cells. The second chamber is separated from the first chamber by ...

08/11/05 - 20050175977 - Hemoglobin isolation and preparation of glycosylated hemoglobin
A method of treating of glycosylated hemoglobin and in particular the process of hemoglobin isolation and preparation of a stable glycosylated hemoglobin in which the glycosylated hemoglobin remains liquid. The method comprises steps including separating human red blood cells from anti-coagulated blood, washing the human red blood cells with physiological ...

08/11/05 - 20050175976 - Meiosis activating sterol augments implantation rate
The present invention relates to the use of a new principle for improving the viability and pregnancy potential of oocytes and pre-embryos obtained in connection with in vitro fertilisation and pre-embryo transfer treatment. More specifically, improvement by raising the content of Meiosis Activating Sterols (MAS) in the medium where the ...

08/04/05 - 20050170327 - Method for preparing platelet-rich plasma
An object of this invention is to provide platelet-rich plasma having high activity easily and at low cost. The object is achieved by a method for preparing platelet-rich plasma comprising a step of adding a water-soluble polymer compound to whole blood obtained by blood collection. For example, by adding poly-L-glutamic ...

07/28/05 - 20050164159 - Carrier for co-culturing a fertilized ovum of an animal and method for culturing a fertilized ovum of an animal using the carrier
There is provided a carrier for co-culturing a fertilized ovum of an animal by which behavior of the fertilized ovum of an animal can be easily observed in a culture system and by which adhesion and three-dimensional growth of the fertilized ovum become possible at first, as well as there ...

07/28/05 - 20050164158 - Microfluidic sorting device
Small particles, for example 5 μm diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises ...

07/28/05 - 20050164157 - System for cellular storage and genetic information retrieval
A system for storage of cellular material and retrieval of genetic information comprises a cell bank comprising a plurality of cell storage units for storage of cellular material from individual depositors. Cryo-preservation of the material is contemplated. Genetic information obtained from the cellular material is complied in a digital information ...

07/21/05 - 20050158700 - Devices for motile sperm separation
Device (10, 110) for separating motile sperm from a sample (100, 200), comprises a vessel (15, 115) having an inlet port (20, 120), an outlet port (35, 135) which is initially closed, a medium (40, 140) into which motile sperm in the sample (100, 200) can migrate into the vessel ...

07/21/05 - 20050158699 - Cryopreservation of plant cells
The present invention relates to methods for cryopreserving plant cells and to methods for recovering viable plant cells from long or short term cryopreservation. Plant cells to be cryopreserved can be grown in culture and pretreated with a solution containing an cryoprotective agent and, optionally, a stabilizer. Stabilizers are preferably ...

07/07/05 - 20050147959 - Tissue analogs for in vitro testing and method of use therefor
A test system and method are disclosed for using tissue analogs The method includes the following steps: (1) isolating the cells to be implanted from donor tissue; (2) seeding the cells onto a particulate microcarrier bead; (3) culturing the cells on the microcarriers to achieve an expansion in the number ...

06/16/05 - 20050130115 - Method for altering the gender ratio of offspring in mammals by manipulation of spermatozoa
The present invention describes a methodology for exploiting differences in the aging rates of X- and Y-bearing spermatozoa to enable pre-selection of gender of offspring in mammals. ...

06/09/05 - 20050123895 - Fat collection and preparation system and method
System and methods for collecting and preparing fat for autologous fat transplantation. The system includes a centrifuge, syringes, and filtering and transferring assemblies coupled with the syringes. Substances, including oil, fat, and denser substances (tumescent fluid, connective tissue, and other non-fat substances), are harvested into a syringe. A dye is ...

06/02/05 - 20050118563 - Method for determining embryo quality
A method for determining embryo quality involving measuring soluble HLA-G levels present in the embryo culture medium at least 44-46 hours post-fertilization is provided. Culture media and in vitro fertilization programs employing same are also provided. ...



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