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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets) patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

07/31/14 - 20140212494 - Methods of improving digestive health
A method of treating constipation is disclosed. The method includes administering starch-entrapped microbeads....

07/31/14 - 20140212495 - Nanoparticulate compositions of tubulin inhibitor compounds
The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment...

07/31/14 - 20140212496 - New abuse-resistant pharmaceutical composition for the treatment of opioid dependence
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles...

07/31/14 - 20140212497 - Coated nanoparticles
The present invention relates to a method for preparing a composition comprising nanoparticles of a noble metal functionalised with at least one type of metal complex and surfactant. The method comprises providing a first solution comprising nanoparticles and surfactant, and a second solution comprising a first type of metal complex,...

07/31/14 - 20140212498 - Oil-in-water emulsions that contain nucleic acids
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the...

07/31/14 - 20140212499 - Compositions and methods for repairing bone
Bone repair compositions comprising bone particles and periosteum tissue. The bone particles may be demineralized, and may comprise powder or fibers from cortical bone or from cancellous bone. The periosteal tissue can be micronized periosteal tissue, and may comprise periosteal powder, particulates, pieces, or combinations thereof. The bone repair composition...

07/31/14 - 20140212500 - Compositions containing diverse natural antigens and uses thereof in balancing immune responses
Compositions containing sterilized antigens with a high diversity, which can be collected from primitive jungle areas, and uses thereof for balancing immune responses and treating immunological diseases in a subject....

07/31/14 - 20140212501 - Compositions of lopinavir
The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester,...

07/24/14 - 20140205665 - Bioresorbable microparticles
Polyurethane microparticles are derived from structural units comprising poly(alkylene oxide) moieties, caprolactone moieties and urethane moieties. The microparticles may include an active agent and have a particle size from 0.1 to 100 microns. Microparticles for injection have a particle size of 15 to 80 microns; for use as a aerosol...

07/24/14 - 20140205666 - Iminosugar in crystalline form
Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof....

07/24/14 - 20140205667 - Method
There is provided a method of producing a mixed metal compound comprising at least Mg2+ and at least Fe3 + having an aluminium content of less than 10000 ppm, having an average crystal size of less than 20 nm (200 A) comprising the steps of: (a) combining a Mg2+ salt...

07/24/14 - 20140205668 - Surface modified proteinaceous spherical particles and uses thereof
An aspect of embodiments of the invention relates to surface modified proteinaceous spherical particles (SMOP). SMOPs according to an embodiment of the invention may comprise a protein layer and an amyloid-binding moiety bound to the protein. In an embodiment, the protein layer is spherical in shape and comprises proteins linked...

07/17/14 - 20140199395 - Novel formulation of meloxicam
The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way...

07/17/14 - 20140199396 - Process for the manufacture of a powder containing lutein
Process for the manufacture of a powder containing lutein, powder obtainable by said process and food composition containing said powder....

07/17/14 - 20140199397 - Benzoyl peroxide microparticle process
The present invention relates to the manufacture of microparticle benzoyl peroxide. The process of the invention provides for an aqueous slurry of USP benzoyl peroxide, optionally containing additives, being processed via microfluidization technology. The process comprises forcing a slurry of benzoyl peroxide at high pressure through a narrow channel designed...

07/17/14 - 20140199398 - High capacity diektopiperazine microparticles and methods
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation....

07/17/14 - 20140199399 - Use of tgf-beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia
The disclosure relates to methods of treating an infant at risk of developing bronchopulmonary dysplasia, including premature infants, by administering a TGF-β antagonist during the perinatal period, including the prenatal period and/or the postnatal period. For administration during the prenatal period, the TGF-β antagonist can be administered either directly to...

07/10/14 - 20140193499 - Bioactive glass composition, its applications and respective preparation methods
The present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor...

07/10/14 - 20140193500 - Dry shampoo comprising urea-formaldehyde
A method of treating hair and/or skin of a human or animal, the method comprising applying to the hair and/or skin a composition comprising particles of a urea formaldehyde polymer wherein the particles have an average size of less then 300 microns; an oil absorption value of greater than 40...

07/10/14 - 20140193501 - Pulmonary delivery in treating disorders of the central nervous system
A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is at least about...

07/10/14 - 20140193502 - Foam prepared from nanoemulsions and uses
The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum, and methods of using such a composition to treat, alleviate, or prevent a disorder of the skin,...

07/10/14 - 20140193503 - Aqueous suspension concentrate comprising an acid salt of dodecylguanidine
The invention concerns a suspension concentrate comprising, expressed by weight based on the total weight of the composition: a) 40 to 80% particles of dodecylguanidine or an acid salt of dodecylguanidine of the structure (1), wherein X represents an acid residue of a monocarboxylic, dicarboxylic or a mineral acid, b)...

07/03/14 - 20140186442 - Topical minocycline compositions and methods of using the same
Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent associated with porous calcium particles. Also provided are methods of using the compositions, e.g., in the treatment of acne....

07/03/14 - 20140186443 - Cyclodextrin nanotechnology for ophthalmic drug delivery
The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), and a solid phase of...

07/03/14 - 20140186444 - Drug formulations having improved pharmacokinetic properties
The present application relates to novel drug formulations of vardenafil which dissolve rapidly in the mouth and lead to increased bioavailability and to a plateau-like plasma concentration profile, and to processes for their preparation....

07/03/14 - 20140186445 - Method for making customised nanoparticles, nanoparticles and uses thereof
A method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. In a first step, a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises...

07/03/14 - 20140186446 - Delivery of biologic therapeutics
Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an...

06/26/14 - 20140178475 - Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles....

06/26/14 - 20140178476 - Highly efficient delivery of a large therapeutic mass aerosol
Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included....

06/26/14 - 20140178477 - Solid preparation
The present invention provides a solid preparation formulation containing a poorly water-soluble agent having a low melting point, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose, in which the saccharide/cellulose weight ratio exceeds 2 and the cellulose content is not less than 5 wt...

06/26/14 - 20140178478 - Immuno-adjuvant emulsion
The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process....

06/26/14 - 20140178479 - Concentrated felbamate formulations for parenteral administration
Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved...

06/19/14 - 20140170220 - Multimodal particulate formulations
Multimodal particulate formulations of medicaments and methods for their use, e.g. by nasal or pulmonary administration for the treatment of various medical conditions, are provided....

06/19/14 - 20140170221 - Methods and compositions for localized delivery of agents to virally infected cells and tissues
The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy...

06/19/14 - 20140170222 - Xanthophyll compositions and methods of use
The present invention encompasses a carotenoid composition, a process for producing a carotenoid composition, and methods of use thereof....

06/19/14 - 20140170223 - Post oxidative hair treatment agent with silicone
b) subsequently, within a time span from about one second to about 24 hours after step a), a post-treatment agent that contains at least one 4-morpholinomethyl-substituted silicone of formula (V), applied onto the keratinic fibers, in particular onto the hair....

06/12/14 - 20140161881 - Reduced dose pharmaceutical compositions of fenofibrate
The present invention provides a reduced dose oral pharmaceutical composition comprising mixture of nanoparticulate fenofibrate and micronized fenofibrate and one or more pharmaceutically acceptable excipients....

06/12/14 - 20140161882 - Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
Particular embodiments disclosed herein relate to electrokinetically altered gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for eye related conditions and/or diseases. In certain embodiments, the electrokinetically altered gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic...

06/12/14 - 20140161883 - Cosmetic compositions with near infra-red (nir) light - emitting material and methods therefor
Cosmetic or dermatological compositions and substrates, containing a NIR light-emitting material, and methods for stimulating healing and/or regenerative properties in the skin, hair and/or scalp are provided....

06/12/14 - 20140161884 - Multistage nanoparticle drug delivery system for the treatment of solid tumors
Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or...

06/12/14 - 20140161885 - Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
The present invention is a method of producing a lanthanum carbonate hydroxide or lanthanum oxycarbonate which has improved properties. The method involves the use of a water soluble lanthanum and a water soluble non-alkali metal carbonate or bicarbonate. The resulting material can be used as a phosphate binder individually or...

06/05/14 - 20140154322 - For injectable formulations containing asenapine and method of treatment using same
The present invention provides a formulation comprising asenapine hemipamoate suspended particles, which formulation can be administered via a Depot provided by an IM injection of the formulation, and which depot does not display a particle-size dependent release rate. The present invention provides also methods of treatment using the same....

06/05/14 - 20140154323 - Method for treating bronchial diseases
Administration of a loop diuretic in nebulized dry powder form directly to a patient's lungs for treating bronchial disease....

05/29/14 - 20140147503 - Pharmaceutical composition comprising deferasirox
The present invention relates to a pharmaceutical composition comprising deferasirox, a process for preparing such pharmaceutical composition, and its use in the treatment of chronic iron overload. The pharmaceutical composition comprises nanosized deferasirox having improved surface area and solubility. It also relates to a method for treatment of chronic iron...

05/29/14 - 20140147504 - Tetracycline topical formulations, preparation and uses thereof
The invention relates to a topical suspension formulation that includes a tetracycline, a liquid medium and a polymeric gelling agent. The tetracycline may be in the form of its pharmaceutically acceptable salts, hydrates, or polymorphs and is in a suspended form within the formulation. The liquid medium is selected such...

05/29/14 - 20140147505 - Solid pharmaceutical dosage form of ticagrelor
The present invention relates to a solid pharmaceutical dosage form comprising ticagrelor as pharmaceutically active ingredient, to certain particles of ticagrelor and to processes of preparing the same....

05/29/14 - 20140147506 - Delivery of submicrometer and nanometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery
Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol...

05/22/14 - 20140141083 - Nanoparticulate meloxicam formulations
The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm....

05/22/14 - 20140141084 - Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
The present invention relates to an amphiphilic polymer whose property and structure can change under hypoxic conditions, and to nanoparticles formed by self-assembly of the amphiphilic polymer. The hypoxia-responsive nanoparticles according to the present invention release a drug selectively under hypoxic conditions. Thus, the nanoparticles can be used for the...

05/22/14 - 20140141085 - Tracer particles, and methods for making same
The invention relates generally to tracer particles for product identification and/or authentication. When incorporated into a manufactured item, that item can be subsequently authenticated by either detecting, or failing to detect, the tracer particle. The tracer particles of the invention are magnetically attractable, with micromarkings, and in some embodiments, are...

05/22/14 - 20140141086 - Injectable depot compositions and uses thereof
Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent....

05/22/14 - 20140141087 - Oral composition comprising an antacid, an anaesthetic and an inorganic matrix comprising silicon dioxide and titanium dioxide
The invention provides an oral composition comprising a pharmaceutically acceptable carrier, at least one antacid, an inorganic matrix comprising at least silicon dioxide and titanium dioxide, and an anaesthetic, wherein the composition is substantially evenly dispersed in the carrier and is palatable....