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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets) patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

08/21/14 - 20140234420 - Method of treating skin disorders using nanoscale delivery devices and transdermal enhancing compositions
The present invention describes methods and compositions for treating diverse dermatological conditions, including acne and psoriasis, using zein containing nanocarrier devices for topical delivery of methotrexate, retinoic acid and benzoyl peroxide to select targets in the skin....

08/21/14 - 20140234421 - Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration
The present invention relates to tetracaine based anesthetic formulations and methods of use thereof. The invention further relates to topical formulations of tetracaine and methods of topically anesthetizing body tissues. The present invention also relates to tetracaine based dental anesthetic formulations and methods for anesthetizing the maxillary dental arch using...

08/21/14 - 20140234422 - Vaccine composition with aluminium hydroxide nanoparticles
A vaccine composition comprising at least one antigen and one adjuvant, characterized in that the adjuvant comprises sterile-filterable nanoparticles comprising pseudo-boehmite and polyacrylate....

08/21/14 - 20140234423 - Programming of cells for tolerogenic therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease....

08/21/14 - 20140234424 - Prame purification
Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange; and (ii) exchanging protein from...

08/21/14 - 20140234425 - Aqueous fungicidal composition and use thereof for combating harmful microorganisms
up to 40% by weight, based on the total amount of the monomers M, of one or more ethylenically unsaturated monomers M2 other than the monomers M1....

08/21/14 - 20140234426 - Cosmetic
A cosmetic, includes: a composite powder containing titanium oxide and 4-tert-butyl-4-methoxybenzoylmethane and having an average particle diameter of less than 1 μm; and sorbitan fatty acid ester represented by the following Formula (I): wherein, in Formula (I), R1 to R4 each independently represent —(CH2)nCOOH, —(CH2)nOH, —R5, or —OR6; R5 represents...

08/21/14 - 20140234427 - Use of synthetic janus particles for preventing or reducing crystal growth
The invention provides a method of preventing or reducing the growth of crystals in a substance which is susceptible to crystal growth in which colloidal particles having an amphiphilic structure, e.g. Janus particles, are contacted with the substance. Colloidal particles suitable for use in the invention include cross-linked, colloidal materials...

08/14/14 - 20140227359 - Diketopiperazine salts for drug delivery and related methods
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described...

08/14/14 - 20140227360 - Stable pharmaceutical composition of clopidogrel free base for oral and parenteral delivery
The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, m) of 100-500 nm, wherein the oil phase comprises clopidogrel free base dispersed in pharmaceutical acceptable oil(s). The emulsion uses clopidogrel free base or premix of clopidogrel free base in oil(s) as the starting materials and may...

08/07/14 - 20140220131 - Personal care compositions containing volumizing, fixative, and conditioning particles for fine hair
The present invention is directed to a personal care composition comprising: a personal care composition comprising a particle complex consisting of a hydrolyzed corn starch, a starch/cellulose polymer, a hydrogenated phospholipid, and gum arabic; and an aqueous carrier. The personal care composition is suitable for delivery as a sprayable composition...

08/07/14 - 20140220132 - Pharmaceutical formulation comprising compounds of the jasmonate family
The current invention pertains to pharmaceutical formulation including at least one jasmonate compound of the jasmonate family of compounds combined with a carrier, such as inclusion compounds, particularly those able to form nano or micro encapsulation systems. The invention generally refers to inclusion complexes which includes jasmonate compounds....

08/07/14 - 20140220133 - Nanotechnology based medicine for biodefense
A composition and methods to bind and remove toxic agents from a subject exposed to the toxic agents are described herein. The composition comprises a stealth agent and scavenging agent bound to a nanoparticle platform. The stealth agent prevents the nanomedicine from detection and elimination by the immune system allowing...

08/07/14 - 20140220134 - Method for treating diabetes with extended release formulation of glp-1 receptor agonists
The disclosure provides methods for treating diabetes, treating overweight, treating obesity, reducing body weight, treating cardiovascular diseases, treating fatty liver diseases, treating gastrointestinal diseases, and treating neurodegenerative diseases through the once monthly administration of pharmaceutical formulations containing a non-aqueous carrier and GLP-1 receptor agonists that provides therapeutically effective plasma concentration...

08/07/14 - 20140220135 - Permeation enhanced active-carrying nanoparticles
Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein an active agent and a permeation enhancer are bound to or associated with the nanoparticles....

08/07/14 - 20140220136 - System and method for delivering protease inhibitors
The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“TA”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce...

08/07/14 - 20140220137 - High activity antiparasitic composition against rhynchophorus ferrugineus
Synergistic composition able to rapidly and efficiently terminate Rhynchophorus ferrugineus infestation, in palms or other species suffering from this parasite. The composition comprises one or more among permethrin, cypermethrin, lambda-cyhalothrin; one or more among chlorpyrifos methyl, and chlorpyrifos ethyl; furthermore, benzisothiazolin-3-one, piperonyl butoxide, imidacloprid. The parasite dies shortly after contact...

08/07/14 - 20140220138 - Enhanced nitric oxide delivery and uses thereof
Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions....

08/07/14 - 20140220139 - Skin composition for external use containing ceramides
The present invention provides a ceramide lamella structure comprising a glucoside surfactant, a preparation method thereof, and a skin composition for external use containing the same. According to the skin preparation composition for external use of the present invention, phase stability is very excellent and a greater amount of ceramides...

08/07/14 - 20140220140 - Compositions of efavirenz
The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester,...

08/07/14 - 20140220141 - Compositions of lopinavir and ritonavir
The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty...

08/07/14 - 20140220142 - Composition for bone regeneration
The present invention provides a composition for bone regeneration comprising: particulate demineralized bone matrix; fibrous demineralized bone matrix; and a hydrate. In addition, it is preferable that the present invention comprises a demineralized solution-derived isolated product obtained by neutralizing a demineralized solution, separated from a demineralization process, and separating the...

07/31/14 - 20140212494 - Methods of improving digestive health
A method of treating constipation is disclosed. The method includes administering starch-entrapped microbeads....

07/31/14 - 20140212495 - Nanoparticulate compositions of tubulin inhibitor compounds
The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment...

07/31/14 - 20140212496 - New abuse-resistant pharmaceutical composition for the treatment of opioid dependence
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles...

07/31/14 - 20140212497 - Coated nanoparticles
The present invention relates to a method for preparing a composition comprising nanoparticles of a noble metal functionalised with at least one type of metal complex and surfactant. The method comprises providing a first solution comprising nanoparticles and surfactant, and a second solution comprising a first type of metal complex,...

07/31/14 - 20140212498 - Oil-in-water emulsions that contain nucleic acids
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the...

07/31/14 - 20140212499 - Compositions and methods for repairing bone
Bone repair compositions comprising bone particles and periosteum tissue. The bone particles may be demineralized, and may comprise powder or fibers from cortical bone or from cancellous bone. The periosteal tissue can be micronized periosteal tissue, and may comprise periosteal powder, particulates, pieces, or combinations thereof. The bone repair composition...

07/31/14 - 20140212500 - Compositions containing diverse natural antigens and uses thereof in balancing immune responses
Compositions containing sterilized antigens with a high diversity, which can be collected from primitive jungle areas, and uses thereof for balancing immune responses and treating immunological diseases in a subject....

07/31/14 - 20140212501 - Compositions of lopinavir
The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester,...

07/24/14 - 20140205665 - Bioresorbable microparticles
Polyurethane microparticles are derived from structural units comprising poly(alkylene oxide) moieties, caprolactone moieties and urethane moieties. The microparticles may include an active agent and have a particle size from 0.1 to 100 microns. Microparticles for injection have a particle size of 15 to 80 microns; for use as a aerosol...

07/24/14 - 20140205666 - Iminosugar in crystalline form
Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof....

07/24/14 - 20140205667 - Method
There is provided a method of producing a mixed metal compound comprising at least Mg2+ and at least Fe3 + having an aluminium content of less than 10000 ppm, having an average crystal size of less than 20 nm (200 A) comprising the steps of: (a) combining a Mg2+ salt...

07/24/14 - 20140205668 - Surface modified proteinaceous spherical particles and uses thereof
An aspect of embodiments of the invention relates to surface modified proteinaceous spherical particles (SMOP). SMOPs according to an embodiment of the invention may comprise a protein layer and an amyloid-binding moiety bound to the protein. In an embodiment, the protein layer is spherical in shape and comprises proteins linked...

07/17/14 - 20140199395 - Novel formulation of meloxicam
The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way...

07/17/14 - 20140199396 - Process for the manufacture of a powder containing lutein
Process for the manufacture of a powder containing lutein, powder obtainable by said process and food composition containing said powder....

07/17/14 - 20140199397 - Benzoyl peroxide microparticle process
The present invention relates to the manufacture of microparticle benzoyl peroxide. The process of the invention provides for an aqueous slurry of USP benzoyl peroxide, optionally containing additives, being processed via microfluidization technology. The process comprises forcing a slurry of benzoyl peroxide at high pressure through a narrow channel designed...

07/17/14 - 20140199398 - High capacity diektopiperazine microparticles and methods
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation....

07/17/14 - 20140199399 - Use of tgf-beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia
The disclosure relates to methods of treating an infant at risk of developing bronchopulmonary dysplasia, including premature infants, by administering a TGF-β antagonist during the perinatal period, including the prenatal period and/or the postnatal period. For administration during the prenatal period, the TGF-β antagonist can be administered either directly to...

07/10/14 - 20140193499 - Bioactive glass composition, its applications and respective preparation methods
The present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor...

07/10/14 - 20140193500 - Dry shampoo comprising urea-formaldehyde
A method of treating hair and/or skin of a human or animal, the method comprising applying to the hair and/or skin a composition comprising particles of a urea formaldehyde polymer wherein the particles have an average size of less then 300 microns; an oil absorption value of greater than 40...

07/10/14 - 20140193501 - Pulmonary delivery in treating disorders of the central nervous system
A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is at least about...

07/10/14 - 20140193502 - Foam prepared from nanoemulsions and uses
The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum, and methods of using such a composition to treat, alleviate, or prevent a disorder of the skin,...

07/10/14 - 20140193503 - Aqueous suspension concentrate comprising an acid salt of dodecylguanidine
The invention concerns a suspension concentrate comprising, expressed by weight based on the total weight of the composition: a) 40 to 80% particles of dodecylguanidine or an acid salt of dodecylguanidine of the structure (1), wherein X represents an acid residue of a monocarboxylic, dicarboxylic or a mineral acid, b)...

07/03/14 - 20140186442 - Topical minocycline compositions and methods of using the same
Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent associated with porous calcium particles. Also provided are methods of using the compositions, e.g., in the treatment of acne....

07/03/14 - 20140186443 - Cyclodextrin nanotechnology for ophthalmic drug delivery
The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), and a solid phase of...

07/03/14 - 20140186444 - Drug formulations having improved pharmacokinetic properties
The present application relates to novel drug formulations of vardenafil which dissolve rapidly in the mouth and lead to increased bioavailability and to a plateau-like plasma concentration profile, and to processes for their preparation....

07/03/14 - 20140186445 - Method for making customised nanoparticles, nanoparticles and uses thereof
A method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. In a first step, a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises...

07/03/14 - 20140186446 - Delivery of biologic therapeutics
Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an...

06/26/14 - 20140178475 - Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles....

06/26/14 - 20140178476 - Highly efficient delivery of a large therapeutic mass aerosol
Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included....

06/26/14 - 20140178477 - Solid preparation
The present invention provides a solid preparation formulation containing a poorly water-soluble agent having a low melting point, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose, in which the saccharide/cellulose weight ratio exceeds 2 and the cellulose content is not less than 5 wt...

06/26/14 - 20140178478 - Immuno-adjuvant emulsion
The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process....

06/26/14 - 20140178479 - Concentrated felbamate formulations for parenteral administration
Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved...