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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)

Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets) patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

09/18/14 - 20140271869 - High drug load buprenorphine microspheres and method of producing same
A sustained release microsphere formulation with a high drug load may be formed by a continuous oil-in-water emulsion process by combining an organic dispersed phase with an aqueous continuous phase. The dispersed phase may include an encapsulating polymer, a primary solvent, such as dichloromethane, a pharmaceutically effective amount of an...

09/18/14 - 20140271870 - Treatment of pain using protein solutions
Methods for treating pain using a protein solution comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets....

09/18/14 - 20140271871 - Methods and compositions for treating pulmonary hypertension
The present invention features methods for treating, stabilizing, preventing, and/or delaying pulmonary hypertension by administering nanoparticles that comprise rapamycin or a derivative thereof and/or nanoparticles that comprise a taxane (e.g., paclitaxel) or a derivative thereof. The invention also provides compositions (e.g., unit dosage forms) comprising nanoparticles that comprise a carrier...

09/18/14 - 20140271872 - Drug delivery system
Disclosed herein are novel methods of treating diseases, novel dosage forms, and novel methods of modulating the pharmacokinetics of active ingredients....

09/18/14 - 20140271873 - Application of encapsulated capsaicin and analogues thereof for controlling calorie intake
A zero-calorie to near-zero-calorie snacking product that, when consumed, provides a feeling of fullness prior to absorption of energy-providing food, i.e., pre-absorptive satiation is disclosed. The snacking product is based on the stimulation of vagal nerve endings in the gastro-intestinal tract by encapsulated capsaicin. The encapsulation of capsaicin avoids the...

09/18/14 - 20140271874 - Stable crystalline monohydrate of epirubicin hydrochloride and method of production
The present invention relates to a stable crystalline monohydrate of epirubicin hydrochloride having water content in the range between 2.7% and 3.5% (w/w) and being devoid of residual solvents as well as to a corresponding method for its production. The method comprises: (a) adding at least a first solvent and...

09/18/14 - 20140271875 - Compositions including encapsulated isotretinoin and methods for use thereof
The present invention provides topical dermal compositions including microsphere encapsulated isotretinoin. Pharmaceutically acceptable salts, esters, or amides of isotretinoin are also contemplated for use in the practice of the invention. The compositions of the invention are useful for treating a variety of conditions associated with excess sebum production, such as,...

09/18/14 - 20140271876 - Ophthalmic formulations
The present invention relates to an ophthalmic formulation which comprises a fine particle of Compound A in an aqueous suspension and a manufacturing process thereof. More specifically, the present invention relates to a topically applied ophthalmic aqueous suspension which is obtainable by suspending fine particles of Compound A in an...

09/18/14 - 20140271877 - Substantially surfactant-free, submicron dispersions of hydrophobic agents containing high levels of water miscible solvent
A composition is provided to apply to the skin, hair, or external mucosa of a human or animal, and a method for using the composition. The composition includes for example a composition for application to skin, hair or external mucosa comprising: a) dispersed submicron particles of hydrophobic agent(s) having average...

09/18/14 - 20140271878 - Crystals of laquinimod sodium and improved process for the manufacture thereof
f) an amount of methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (MCQME) in the mixture is no more than 0.12% relative to the amount of laquinimod sodium as measured by HPLC....

09/18/14 - 20140271879 - Fine dry particulate retinoid active agent compositions and topical formulations including the same
Fine dry particulate retinoid compositions suitable for use in topical formulations, as well as methods of making the same, are provided. In the dry particulate retinoid compositions, the retinoid active agent is associated with the particles, e.g., via entrapment in the pores of the particles and/or ionic binding and/or non-covalent...

09/18/14 - 20140271880 - Fine dry particulate resveratrol active agent compositions and topical formulations including the same
Fine dry particulate resveratrol compositions suitable for use in topical formulations, as well as methods of making the same, are provided. In the dry particulate resveratrol composition, the resveratrol active agent is associated with the particles, e.g., via entrapment in the pores of the particles and/or ionic binding and/or non-covalent...

09/18/14 - 20140271881 - Antiseptic composition
The invention relates to an antiseptic composition. The composition comprises an association of at least silver metal, preferably in a micronised form, and hyaluronic acid or one of the salts thereof having a molecular weight of between 50 kDa and 2000 kDa. The invention can be especially applied to the...

09/18/14 - 20140271882 - 17-hydroxyprogesterone ester containing oral compositions and related methods
The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically...

09/18/14 - 20140271883 - Curcuminoids and metabolites thereof for treating allergic nasal conditions
A pharmaceutical composition for nasal administration comprising: a nanoemulsified curcumin component; a liquid medium for the curcumin component; and a pharmaceutically acceptable excipient. The curcumin component is a natural curcuminoid, a synthetic curcuminoid, a metabolite of a natural or synthetic curcuminoid, or a mixture thereof. The excipient is effective in...

09/18/14 - 20140271884 - High-loading nanoparticle-based formulation for water-insoluble steroids
Compositions comprising water-insoluble steroids encapsulated into nanoparticle forms are provided. Methods of preparing water-insoluble steroids encapsulated in a nanoparticle form are provided. Methods of treating disease by delivering a water-insoluble steroid encapsulated into nanoparticle form to a patient in need thereof are provided....

09/11/14 - 20140255488 - Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof
The present invention relates to a long-acting sustained-release dosage form for treatment of Parkinson Disease, comprising a dopamine receptor agonist and a pharmaceutically acceptable biodegradable polymer accessories, wherein the content of the dopamine receptor agonist in the sustained-release dosage form is 5-50% by weight, and the content of the pharmaceutically...

09/11/14 - 20140255489 - Consistent calcium content bone allograft systems and methods
Embodiments of the present invention provides bone graft compositions, and methods for their use and manufacture. A bone graft composition may include a first amount of non-demineralized cancellous bone. The composition may further include a second amount of demineralized cancellous bone. The composition may also include a third amount of...

09/11/14 - 20140255490 - Particularly storage-stable and thixotropically stable prophylaxis paste for professional dental use
where the buffer component c.) is based on hydrogen phosphate and keeps the pH of the prophylaxis paste, measured in a 10% suspension (w/w) of the paste in water against a pH electrode, between 7 and 8....

09/11/14 - 20140255491 - Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
Inhalation solutions for administration of muscarinic antagonists for the treatment of breathing disorders, such as COPD, are provided....

09/11/14 - 20140255492 - Fine dry particulate adenosine compositions and topical formulations including the same
Fine dry particulate adenosine compositions suitable for use in topical formulations, as well as methods of making the same, are provided. In the dry particulate adenosine composition, the adenosine active agent is associated with the particles, e.g., via entrapment in the pores of the particles and/or ionic binding and/or non-covalent...

09/11/14 - 20140255493 - Extrudate and methods of using said extrudate
The invention relates to a method for the preparation of a silicic acid comprising extrudate, comprising the steps of: i) forming of stabilised silicic acid, by hydrolysing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound, or...

09/11/14 - 20140255494 - Novel formulation of indomethacin
The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way...

09/11/14 - 20140255495 - Colon lavage system
The present invention provides compositions, systems, kits, and methods for preparation prior to a colonoscopy or other gastrointestinal procedure. In particular, the present invention provides a colon lavage system comprising an aqueous portion and a solid portion....

09/11/14 - 20140255496 - Micronized placental tissue compositions and methods of making and using the same
Described herein are compositions composed of micronized placental components, extracts of micronized placental components, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions and the extracts thereof are also described herein....

09/11/14 - 20140255497 - Organic compounds
A solid pharmaceutical composition suitable for oral administration, comprising: (a) S 1 P receptor agonist; and (b) a sugar alcohol....

09/11/14 - 20140255498 - Pharmaceutical nanosuspension
The present invention in general relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one active ingredient and at least one dicarboxylic acid. It in particular relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one anthelmintic drug and at least one dicarboxylic acid. The invention...

09/11/14 - 20140255499 - Method of forming fine particles of a drug substance
A method of forming fine particles of a drug substance using a piston-gap high pressure homogeniser....

09/04/14 - 20140248354 - Controlled release vaccines and methods for treating brucella diseases and disorders
Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates...

09/04/14 - 20140248355 - 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients....

09/04/14 - 20140248356 - 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients....

09/04/14 - 20140248357 - Respiratory disease treatment
A pharmaceutical composition adapted for pulmonary administration by inhalation is described, wherein the composition comprises a glitazone and one or more pharmaceutically acceptable carriers and/or excipients, wherein the glitazone content of the composition consists of at least 95% by weight of the 5R enantiomer and less than 5% by weight...

09/04/14 - 20140248358 - Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles....

09/04/14 - 20140248359 - Novel formulation of diclofenac
The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way...

09/04/14 - 20140248360 - Nanoparticle tumour vaccines
The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a CTL response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier,...

09/04/14 - 20140248361 - Herbal extract composition and a process thereof
A composition is provided that includes extracts of green tea and rosemary extract optionally along with adjuvant and/or excipient. In addition, provided is a process for the preparation of said composition. Also provided is a composition including extract of green tea, rosemary extract and synthetic antioxidant optionally along with adjuvant...

09/04/14 - 20140248362 - Sustained-release preparation
Provided is a sustained-release preparation containing pioglitazone or a salt thereof as an active ingredient and showing superior sustainability. A sustained-release preparation containing pioglitazone or a salt thereof, which shows a dissolution ratio of pioglitazone of average 25-58% at the 2-hour time point, and average 60-100% at the 4-hour time...

08/28/14 - 20140242171 - Oil-in-water emulsion of mometasone and propylene glycol
Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, propylene glycol and water and the weight ratio between the propylene glycol and water...

08/28/14 - 20140242172 - Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith....

08/28/14 - 20140242173 - Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that...

08/28/14 - 20140242174 - Treating cough and tussive attacks
The invention is directed towards carcainium in the form of a salt having an anion An−, wherein An− is an anion of pharmaceutically acceptable acid for use in the treatment and/or suppression of cough, tussive attacks or tussive episodes in a patient....

08/21/14 - 20140234420 - Method of treating skin disorders using nanoscale delivery devices and transdermal enhancing compositions
The present invention describes methods and compositions for treating diverse dermatological conditions, including acne and psoriasis, using zein containing nanocarrier devices for topical delivery of methotrexate, retinoic acid and benzoyl peroxide to select targets in the skin....

08/21/14 - 20140234421 - Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration
The present invention relates to tetracaine based anesthetic formulations and methods of use thereof. The invention further relates to topical formulations of tetracaine and methods of topically anesthetizing body tissues. The present invention also relates to tetracaine based dental anesthetic formulations and methods for anesthetizing the maxillary dental arch using...

08/21/14 - 20140234422 - Vaccine composition with aluminium hydroxide nanoparticles
A vaccine composition comprising at least one antigen and one adjuvant, characterized in that the adjuvant comprises sterile-filterable nanoparticles comprising pseudo-boehmite and polyacrylate....

08/21/14 - 20140234423 - Programming of cells for tolerogenic therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease....

08/21/14 - 20140234424 - Prame purification
Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange; and (ii) exchanging protein from...

08/21/14 - 20140234425 - Aqueous fungicidal composition and use thereof for combating harmful microorganisms
up to 40% by weight, based on the total amount of the monomers M, of one or more ethylenically unsaturated monomers M2 other than the monomers M1....

08/21/14 - 20140234426 - Cosmetic
A cosmetic, includes: a composite powder containing titanium oxide and 4-tert-butyl-4-methoxybenzoylmethane and having an average particle diameter of less than 1 μm; and sorbitan fatty acid ester represented by the following Formula (I): wherein, in Formula (I), R1 to R4 each independently represent —(CH2)nCOOH, —(CH2)nOH, —R5, or —OR6; R5 represents...

08/21/14 - 20140234427 - Use of synthetic janus particles for preventing or reducing crystal growth
The invention provides a method of preventing or reducing the growth of crystals in a substance which is susceptible to crystal growth in which colloidal particles having an amphiphilic structure, e.g. Janus particles, are contacted with the substance. Colloidal particles suitable for use in the invention include cross-linked, colloidal materials...

08/14/14 - 20140227359 - Diketopiperazine salts for drug delivery and related methods
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described...

08/14/14 - 20140227360 - Stable pharmaceutical composition of clopidogrel free base for oral and parenteral delivery
The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, m) of 100-500 nm, wherein the oil phase comprises clopidogrel free base dispersed in pharmaceutical acceptable oil(s). The emulsion uses clopidogrel free base or premix of clopidogrel free base in oil(s) as the starting materials and may...