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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Matrices > Synthetic Polymer Synthetic PolymerSynthetic Polymer patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.07/19/07 - 20070166384 - Methods , composition and preparations for delivery of immune response modifiers A soluble IRM-polymer complex, preparations thereof, and methods of use, wherein the soluble IRM-polymer complex includes one or more IRM compounds attached (e.g., covalently attached) to a polymer (e.g., an alkylene oxide-containing polymer). ... 07/19/07 - 20070166383 - Anionic hydrogel matrices with ph dependent modified release as drug carriers Compositions with pH-dependent modified release are described, consisting of hydrogel matrices containing one or more active ingredients, in which said matrices are suitable for releasing said active ingredients in a prolonged manner in given sites of the body. ... 07/19/07 - 20070166382 - Bioresponsive polymer system for delivery of microbicides The polymer systems of the present invention degrade in the presence of an ejaculate. They may further provide degradable sequences that degrade upon contact with an ejaculate and/or microbicides. The polymer systems of the present invention are of use in the oral, rectal or vaginal cavities of an individual for ... 07/05/07 - 20070154556 - Injectable gel-type bone-repairing material and preparing method thereof The present invention provides an injectable gel-type bone-repairing bioactive material and its preparation method. Each unit dose of said material is composed of 1 ml of component A and 45 to 55 mg of component B, wherein each milliliter sterile saline of component A contains: 10 to 40 mg alginate, ... 07/05/07 - 20070154555 - Augmentation of intraluminal microvessel formation to facilitate guide wire crossing in chronic total occlusions Method of preparing a clogged animal vessel, e.g. chronic total occlusion of an artery so as to be capable of crossing by a guidewire of an intraluminal device, e.g., angioplasty balloon. The method includes delivering an angiogenic agent to the occlusion site to promote angiogenesis within the occlusion to increases ... 07/05/07 - 20070154554 - Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix ... 06/28/07 - 20070148247 - Pharmaceutical composition which reduces or eliminates drug abuse potential A pharmaceutical composition which reduces or eliminates the drug abuse potential of central nervous system stimulant comprising: (a) a drug selected from the group consisting of methylphenidate, amphetamine, methamphetamine, and combinations thereof; and (b) a gel forming polymer wherein the gel forming polymer is a polymer that forms a gel ... 06/28/07 - 20070148246 - Nucleic acid-based matrixes Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis. ... 06/28/07 - 20070148245 - Compressed solid dosage forms with drugs of low solubility and process for making the same One of the objects of the present invention is directed to a process of preparing a pharmaceutical formulation of a drug of low aqueous solubility, comprising (A) fixing the drug in a strong matrix comprising at least one at least partially amorphous sugar to obtain a sugar-drug matrix; and (B) ... 06/28/07 - 20070148244 - Drug delivery systems wherein x, y, m, m′, R, R1, R2, R3, R4, R5, R6, R7, X, Z and Z′ are as defined herein and (b) silicon hydride-containing monomers are provided, wherein the matrix controlled diffusion drug delivery systems are sized and configured for back of the eye delivery. ... 06/21/07 - 20070141156 - Compositions and methods for preventing or reducing postoperative ileus and gastric stasis Disclosed are compositions and methods for preventing or reducing postoperative ileus and gastric stasis. Such compositions comprise a combination of an oxidized regenerated cellulose component and a non-steroidal anti-inflammatory drug (NSAID) which functions as an inhibitor of cyclooxygenase enzyme (Cox) activity. Such methods comprise administering an effective amount of the ... 06/14/07 - 20070134333 - Methods of bonding or modifying hydrogels using irradiation This invention provides methods and processes to attach or bond hydrogels to suitable surfaces using irradiation techniques and also provides methods and processes to create crosslinked regions in hydrogel articles using these irradiation techniques. Specifically, lasers at wavelengths tuned to the irradiation absorption bands of hydroxyl groups, carboxylic acid groups ... 06/14/07 - 20070134332 - Polymer particles for delivery of macromolecules and methods of use The present invention provides biodegradable polymer particle delivery compositions for delivery of macromolecular biologics, for example in crystal form, based on polymers, such as polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers, which contain amino acids in the polymer. The polymer particle delivery compositions can be formulated ... 06/07/07 - 20070128284 - Treatment of xerostomia Xerostomia is treated with a sulfur-containing antioxidant, such as N-acetylcysteine. Delivery compositions including polyoxyalkylene block copolymers may be used, which may be formulated to exhibit reverse-thermal viscosity behavior. ... 05/24/07 - 20070116766 - Gel compositions as muscle tissue simulant and related articles and methods Gel composition comprising thermoplastic block copolymer and oil suitable for use as simulants for body tissue, and methods related to the compositions. ... 05/24/07 - 20070116765 - Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation An aqueous dispersion of hydrogel nanoparticles and methods of making the aqueous dispersion of hydrogel nanoparticless having an interpenetrating polymer network (“IPN”) are described. The uniformed sized mono-disperse IPN nanoparticles have inverse thermo gelation properties that allow therapeutic medications to be uniformly distributed in a liquid form of the aqueous ... 05/17/07 - 20070110811 - Methods for reducing the mitogenicity of lectin compositions Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions. Additionally or alternatively, the reduction in T-cell mitogenicity is achieved by removing unmodified subunits chemically modified mixtures. Modified lectin compositions with reduced T-cell mitogenicity ... 05/17/07 - 20070110810 - Transdermal drug delivery systems, devices, and methods employing hydrogels Systems, devices, and methods for transdermal delivery of one or more therapeutic active agents to a biological interface. An iontophoretic drug delivery system is provided for transdermal delivery of one or more therapeutic active agents to a biological interface of a subject. The iontophoretic drug delivery system includes at least ... 05/17/07 - 20070110809 - Stabilised compositions This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE protein, compositions comprising a substantially integral bARE class protein and immunogenic composition ... 05/03/07 - 20070098799 - Mineralized hydrogels and methods of making and using hydrogels The present invention provides mineralized hydrogels and methods of making and using mineralized hydrogels, by combining a first mixture including a calcium derivative, a second mixture including a phosphate derivative and a hydrogel to form a calcium phosphate dispersion containing the hydrogel. The hydrogel in the calcium phosphate dispersion are ... 05/03/07 - 20070098798 - Method and article to restore function to a flow control location in a patient Article and method of restoring function to a flow control location in a patient. A biological agent is inserted into a region near the flow control location. The biological agent is stabilized in the region. The biological agent is a biological agent selected from a group consisting of growth factors, ... 04/26/07 - 20070092571 - Non-irritating formulation and method for the intradermal delivery of substances This invention describes a composition of matter to facilitate intra-dermal delivery of a great variety of active substances, especially including high molecular weight cosmicuticals. Also disclosed is a method of forming the composition of matter and applying topically to patients, especially using a cream or patch. The active substance is ... 04/19/07 - 20070087060 - Ultrasound coupling medium for use in medical diagnostics A composition of an ultrasound coupling medium is provided. The composition comprises at least 90% water, at least one preservative, and at least one base substance, wherein the composition is extensible into a film with a thickness of up to 1/10 mm, wherein the composition can withstand a pressure of ... 04/12/07 - 20070082053 - Solid dispersions of opioid antagonists Solid dispersions of stable, amorphous opioid antagonists, particularly [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid, with improved water solubility and bioavailability are disclosed. Also disclosed are methods of preventing or treating a side effect associated with an opioid. In addition, methods of treating or preventing pain, ileus, and opioid bowel dysfunction are disclosed. ... 04/12/07 - 20070082052 - Tympanic membrane repair constructs The invention features methods of making hydrogel constructs that can be used to repair perforations in tympanic membranes, the hydrogel constructs themselves, and methods of repair. ... 04/05/07 - 20070077304 - Sustained release small molecule drug formulation An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and ... 04/05/07 - 20070077303 - Methods for providing oxidatively stable ophthalmic compositions This invention relates to a process for improving the stability of an ophthalmically compatible solution comprising at least one oxidatively unstable ophthalmic compound. ... 04/05/07 - 20070077302 - Methods for stabilizing ophthalmic compositions The present invention relates to a method comprising stabilizing, during autoclaving, an oxidatively unstable ophthalmic compound dissolved in an ophthalmic solution by incorporating a stabilizing effective amount of at least one electron rich polymer in said ophthalmic solution. ... 03/29/07 - 20070071824 - Treatment of mucositis using n-acetylcysteine This present invention provides a therapeutic composition for use in the treatment of mucositis and a method for using such a therapeutic composition. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer. ... 03/15/07 - 20070059369 - Subcutaneous delivery system, process for the preparation of the same and use of the same for the treatment of cholinergic deficient disorders The present invention relates to a subcutaneous delivery system comprising a biodegradable polymeric matrix and at least one of the pharmacologically active substances of general formula (I): wherein A represents an amino group —NH2 or an ammonium group —NH3+ or a residue of general formula (II): wherein each of X1 ... 03/08/07 - 20070053985 - Coenzyme q10-containing fine particle with excellent dispersibility The present invention has an object to provide coenzyme Q10-containing particles, which can be easily and simply dispersed into water without any surfactants or other additives, and their production method. The present invention makes it easier to prepare an aqueous dispersion containing coenzyme Q10, which is hard to disperse in ... 03/08/07 - 20070053984 - Topical gels compositions Topical alcoholic gel compositions are disclosed that are useful for delivering therapeutic levels of an NSAID to target in and below the skin. The compositions comprise a topically active drug, an alcoholic solvent, a polymeric thickener, and optionally a keratolytic agent. In one embodiment, excellent viscosity for dermal application is ... 03/08/07 - 20070053983 - Extended release compositions of metoprolol succinate The present invention relates to sustained release solid pharmaceutical composition comprising antihypertensives, in particular, Metoprolol succinate or pharmaceutically acceptable derivatives thereof and a process for preparing such a formulation. The present invention is a composition comprising Metoprolol succinate or its pharmaceutically acceptable derivatives thereof and the composition releases the drug ... 02/15/07 - 20070036866 - Cationic block copolymers The invention relates to cationic block copolymers of formula A(—X—B)n or C(—Y—D)m, wherein A represents a hydrophilic polymer, B represents polyethyleneimine (PEI), X represents a bridge, n represents 1-200, C represents PEI, D represents the residue of a polyethylene glycol, Y represents a bridge and m represents 1-200. The invention ... 02/15/07 - 20070036865 - Endosomolytic polymers We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment. ... 02/15/07 - 20070036864 - Hygeine product for mouth An oral hygiene product, such as tooth paste, is described. A methos for controlling undesirable bacterial flora in the oral cavity, as well as the use of the plant Sphagnum, are also described. ... 02/08/07 - 20070031500 - Long-acting solid formulation comprising triptorelin acetate The invention relates to a long-acting solid formulation for parenteral administration, comprising a) triptorelin acetate and b) one or more excipients comprising a polymer or copolymer of lactic and/or glycolic acid or a mixture of polymers and/or copolymers of lactic acid and/or glycolic acid, said formulation containing 10 to 99% ... 02/08/07 - 20070031499 - Readily shapeable xerogels having controllably delayed swelling properties Hydrogels are described which have delayed swelling properties. A hydrogel is formed by reacting a hydrophilic monomer, a first crosslinker, and a second crosslinker. The first crosslinker defines the volume expansion of the hydrogel in an aqueous environment, and the second crosslinker, which is biodegradable, can modulate the swelling rate ... 02/08/07 - 20070031498 - Gel composition for cellular adhesion inhibition The invention includes compositions for inhibiting cellular adhesion, methods of preparation of such compositions, and methods for preventing cell adhesion at a surgical site comprising application of such compositions. The compositions generally comprise a cellular adhesion inhibitory agent, such as dextran sulfate, and a crosslinked hydrogel matrix, preferentially physically entrapping ... 02/01/07 - 20070026073 - Amorphous efavirenz and the production thereof Efavirenz compositions of enhanced bioavailability are described that contain efavirenz with at least one solubility-enhancing polymer. Described methods to produce the bioenhanced products comprise solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising efavirenz, a solubility-enhancing polymer and a single solvent, a solvent ... 02/01/07 - 20070026072 - Benzoquinones of enhanced bioavailability Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q1O. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the ... 02/01/07 - 20070026071 - Magnesium salt proton pump inhibitor dosage forms The present invention concerns oral dosage formulations of sparingly to very slightly water soluble proton pump inhibitors, the oral dosage forms so made, and methods of use thereof. The oral dosage form has a core tablet of compressed particles composed of powder particles of a pharmaceutically acceptable material, having coated ... 02/01/07 - 20070026070 - Cross-linked polysaccharide composition The present invention provides a process for making cross-linked polysaccharide gels under basic conditions. More particularly, the present invention provides a process for forming cross-linked hyaluronic acid gels under basic conditions. The resulting gels possess improved degradation characteristics, and are useful in a variety of medical and cosmetic applications. ... 02/01/07 - 20070026069 - Biommetic hierarchies using functionalized nanoparticles as building blocks The invention provides a three-dimensional construct including a polymeric matrix and a nanoparticle as shown in FIG. 1 having a diameter of about 5 nm to about 10 microns, wherein the nanoparticle is (a) coated with at least two monomolecular layers each carrying biological information and (b) dispersed in the ... 01/25/07 - 20070020336 - Cyclodextrin nanotechnology for ophthalmic drug delivery The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), and a solid phase of ... 01/25/07 - 20070020335 - Sustained release pharmaceutical compositions for highly water soluble drugs The present invention provides pharmaceutical compositions for controlled release of pharmaceutically active agents, especially those with a high water solubility, high dose, and/or short half-life. In addition, the present application provides methods for preparing and using such pharmaceutical compositions. ... 01/18/07 - 20070014861 - Treatment of proctitis A method for treatment of proctitis is disclosed in which a therapeutic composition is introduced into the rectum to contact a mucosal surface within the rectum. The pharmaceutical composition comprises a reverse-thermal gelation polyoxyalkylene block copolymer, a pharmaceutical substance and a pharmaceutical substance selected from the group consisting of glutathione ... 01/18/07 - 20070014860 - Treatment of esophagitis A method for treatment of esophagitis is disclosed in which a therapeutic composition is introduced into the esophagus to contact a mucosal surface within the esophagus. The pharmaceutical composition comprises a reverse-thermal gelation polyoxyalkylene block copolymer, a pharmaceutical substance and a pharmaceutical substance selected from the group consisting of glutathione ... 01/11/07 - 20070009602 - Direct drug delivery system based on thermally responsive biopolymers A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) ... 01/11/07 - 20070009601 - Composition and method for the treatment of water related ear disorders This invention provides a method for the treatment of water related outer ear canal disorders comprising the steps of applying a water resistant and antimicrobial film topically to the external ear canal. The invention includes a composition for the treatment of water related outer ear canal disorders comprising a water ... 01/04/07 - 20070003626 - Sterile in-situ microcarrier forming gelled polymeric dispersions and processes to manufacture the same These inventions is in the field of drug delivery systems comprising of sterile gelling agents and in-situ polymeric gelled dispersions which maybe microparticulate for parentral administration and contain a therapeutically active component. They may release the active agent immediately or over a period of time. ... 01/04/07 - 20070003625 - Biodegradable branched polylactide derivatives capable of forming polymeric micelles, and their preparation method and use The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: <formula 1> 1-(R—X)n wherein each of X, R, I and n is defined as in the detailed description. ... 12/28/06 - 20060292223 - Gel compositions for topical administration Pharmaceutical gel compositions containing pharmacologically active agent for topical administration, as well as a method of making the same, are disclosed. ... 12/21/06 - 20060286171 - Bone morphogenetic protein formulations Protein formulations that can be lyophilized and are stable in organic solvents. The formulations contain bone morphogenetic proteins, lyoprotectants, and oxidation/reduction stabilizers. Optionally, the formulations may also contain solvent environment stabilizers. The protein formulations can be incorporated into a polymeric matrix to make medical devices for delivering the protein, and ... 12/21/06 - 20060286170 - Method and composition for treating cancer using cellular organelle crystallizing agents This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular organelle and/or cytoskeleton crystallizing agents (e.g. tetrazolium salts and their derivatives), pharmaceutical compositions containing a therapeutically effective amount of organelle and/or cytoskeleton crystallizing agents, and compositions containing ... 12/21/06 - 20060286169 - Lipophilic compositions There is described dry compositions comprising lipophilic compounds associated with low viscosity grades of water insoluble polymer and optionally hydrophilic agent/s associated either as monomolecular or amorphous complexes. There is also described a method of preparing said lipophilic polymer complexes from a solution or homogeneous dispersion employing either water miscible ... 12/14/06 - 20060280797 - Blends of temperature sensitive and anionic polymers for drug delivery A physical blend of inverse thermal gelling and shear-thinning, thixotropic polymers that has a lower gelation temperature than the thermal gelling polymer alone is provided. The blend results in an injectable hydrogel that does not flow freely at room temperature, but is injectable due to its shear-thinning properties. The thermal-gelling ... 12/07/06 - 20060275370 - Method and compositions for treatment of epithelial damage The present invention is directed to methods and compositions of treating or preventing epithelial lining tissue damage from dermatitis or mucositis induced by radiation exposure and/or chemotherapy, by applying to skin, mucosa or other tissues of the body an amount of a therapeutic composition which comprises a histone deacetylase inhibitor ... 12/07/06 - 20060275369 - Orally therapeutic plastics and devices formed therefrom The present invention provides methods whereby a thermally formable plastic is compounded with releasable active ingredients. The compounded plastic is then formed into a desired dental delivery device such as an anatomical membrane, tray or strip. The dental device is then placed in the oral environment where it will release ... 12/07/06 - 20060275368 - Biocompatible polymer The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the ... 11/30/06 - 20060269608 - Pharmaceutical formulation The present invention provides processes for making and forms of solid dispersions of pharmaceutical active ingredients. ... 11/23/06 - 20060263431 - Opioid sustained release formulation A solid, oral, controlled release dosage form comprising a therapeutically effective amount of an opioid compound, or a salt thereof, a matrix-forming polymer and an ionic exchange resin. ... 11/16/06 - 20060257488 - Injectable hydrogels and methods of making and using same A biocompatible hydrogel and method for augmenting soft and hard tissue, wherein the hydrogel comprises at least one gel former and the hydrogel is used to augment tissue when introduced into a desired tissue site. The hydrogel may comprise at least one of a carbomer, a poloxamer and a combination ... 11/16/06 - 20060257487 - Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders Topical aqueous suspension compositions of sparingly soluble ophthalmic drugs are disclosed. The compositions comprise a combination of a poloxamer or meroxapol surfactant and a glycol tonicity-adjusting agent such as propylene glycol. ... 11/16/06 - 20060257486 - Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders Topical aqueous suspension compositions of sparingly soluble ophthalmic drugs are disclosed. The compositions comprise a combination of a poloxamine nonionic surfactant and a glycol tonicity-adjusting agent such as propylene glycol. ... 11/16/06 - 20060257485 - Method of producing hybrid polymer-inorganic materials The present invention describes a new approach to producing hybrid composite materials with multiscale morphologies. We doped polymer submicrometer spheres with semiconductor or metal (e.g. CdS or Ag, respectively) nanoparticles and used these doped microspheres as the functional building blocks in production of hybrid periodically structured materials. The preparation of ... 11/02/06 - 20060246139 - Bioabsorbable pharmaceutical formulation A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the ... 11/02/06 - 20060246138 - Polyoxaester suspending vehicles for use with implantable delivery systems Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can ... 11/02/06 - 20060246137 - Complex matrix for biomedical use A complex matrix is constituted by at least one biocompatible polymer of natural origin, cross linked and to which are grafted small chains of a molecular weight less than 50,000 Da with an amount of grafting of 10 to 40%, as well as a process for preparation of a biocompatible ... 10/26/06 - 20060240110 - Multifunctional and biologically active matrices from multicomponent polymeric solutions The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the ... 10/12/06 - 20060228416 - Methods for modulating topical inflammatory response A method of modulating topical inflammatory response is disclosed. The method generally includes the selective removal of certain proteins, e.g., one or more cytokines such as interleukin-1β (IL-1β) and/or interleukin-6 (IL-6), from a topical site without substantially altering the local concentrations of other proteins that may be present at or ... 10/05/06 - 20060222712 - Acne gel This combination of clindamycin (1%) and tretinoin (0.025%), solubilized in a hydrogel, resulted in significantly greater improvements in acne vulgaris (reduced lesion counts and ISGA) than either drug alone or vehicle and effectively treated both non-inflammatory and inflammatory lesions with a convenient, once-daily application. ... 09/21/06 - 20060210635 - Injectable gel-forming compositions based on cross-linked and non-cross-linked polymers and the use thereof The invention relates to injectable gel-forming compositions which contain an association of linear and cross-linked polymers and are embodied in the form of a suspension. The use of said compositions, in particular for filling pipes and cavities is also disclosed. ... 09/14/06 - 20060204583 - Chemoembolisation A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin. ... 09/14/06 - 20060204582 - Multiple phase cross-linked compositions and uses thereof The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the ... 09/14/06 - 20060204581 - Biomimetic organic/inorganic composites, processes for their production, and methods of use The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion ... 09/14/06 - 20060204580 - Biomimetic organic/inorganic composites, processes for their production, and methods of use The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion ... 09/14/06 - 20060204579 - Method for improving adsorption of a drug from ethylene oxide derivative The present invention relates to a method for improving adsorption on the gastrointestinal mucous layers of one or more selected from polyethylene glycol, polyethylene oxide, and polyoxyethylene polypropylene copolymer wherein the average number of repeating oxyethylene units of one ethylene oxide chain length is 17 or greater. It is possible ... 09/07/06 - 20060198892 - Polymeric systems for controlled drug therapy Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are ... 09/07/06 - 20060198891 - Solid formulations of liquid biologically active agents The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably ... 08/31/06 - 20060193918 - Solvent/polymer solutions as suspension vehicles A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group ... 08/31/06 - 20060193917 - Radiosensitizer formulations and methods for use The present invention provides radiosensitizer compositions, in controlled-release formulations or other acceptable formulations, particularly nitrohistidine radiosensitizer compositions, which may be administered by any suitable means including oral, intravenous, arterial infusion, intraperitoneal, intramuscular, subcutaneous, surgical, and topical. Optionally, radiosensitizer compositions may be formulated with other agents, including chemotherapy agents and agents ... 08/31/06 - 20060193916 - Formulations of peptides for periodontal and dental treatments Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and/or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to ... 08/10/06 - 20060177511 - Antiseptic compositions and methods Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least ... 07/27/06 - 20060165800 - Short duration depot formulations Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The ... 07/27/06 - 20060165799 - Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can easily be administered into the missing part of injured bone. Since the composition of the present ... 07/20/06 - 20060159764 - Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte ... 07/13/06 - 20060153920 - Lyophilized pharmaceutical compositions Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a ... 07/13/06 - 20060153919 - Ligand-mediated controlled drug delivery Disclosed are systems and methods that can be utilized to define and control the delivery rate of a biological agent from a carrier matrix such as a biocompatible hydrogel. The carrier matrices of the present invention can include ligands incorporated within the matrix at a predetermined concentration level (CLT). In ... 07/06/06 - 20060147534 - Methods of inhibiting or inducing bone formation The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding ... 07/06/06 - 20060147533 - Antimicrobial biomaterial for blood bags An antimicrobial biomaterial including a polymer substrate and silver particles bound to at least a portion of a surface of the polymer substrate. The antimicrobial biomaterial is useful in various medical devices, particularly blood or blood component storage bags, that contact or contain human blood, blood components, and/or other bodily ... 06/29/06 - 20060141040 - Injectable non-aqueous suspension The present invention relates generally to compositions and methods for administering a biologically active agent, and more specifically to injectable non-aqueous suspensions. ... 06/29/06 - 20060141039 - Oral compositions containing oxidized camellia Oral composition comprising a Camellia extract of semi-oxidized tissue from a member of the genus Camellia and an enhancing agent. ... 06/29/06 - 20060141038 - Bilayer tablets of oxcarbazepine for controlled delivery and a process of preparation thereof The present invention describes how to obtain composite products comprising an active substance supported by a carrier, in which the carrier is the linear copolymer of N-vinyl-2-pyrrolidone with vinyl acetate. The composite products are obtained by co-grinding of the dry mixture of the active substance and of the aforesaid carrier. ... 06/22/06 - 20060134218 - Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting ... 06/15/06 - 20060127482 - Combination of immuno gene therapy & chemotherapy for treatment of cancer & hyperproliferative diseases Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection. ... 06/15/06 - 20060127481 - Ophthalmic drug delivery system using polymer micell The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective ... 06/08/06 - 20060121118 - Antimycotic gel having high active compound release is suitable for the treatment and prophylaxis of dermatomycoses. ... 06/08/06 - 20060121117 - Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions. ... 06/08/06 - 20060121116 - Hydrogel for cell separation and method of separating cells Cell/organism is separated by using a hydrogel capable of selectively moving a cell in accordance with a difference in the concentration of a physiologically active substance. The invention provides a hydrogel capable of conducting separation (fractionation, differential separation, fractional collection) of cell/organism having a variety of taxes, which could not ... 06/08/06 - 20060121115 - Composition having gelling properties for the prolonged delivery of bioactive substances The invention relates to a heat-sensitive composition in liquid form, containing: an organic hydrophobic liquid; an organogelling substance, the molecules of which can be bound to one another by low energy linkages; and a bioactive substance, which switches to organogel form upon coming into contact with a physiological fluid during ... 05/18/06 - 20060105046 - Polymer conjugates of opioid antagonists The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the ... 05/18/06 - 20060105045 - Cyclodextrin solubilizers for liquid and semi-solid formulations This invention is directed to compositions comprising a water-miscible organic solvent or solvent mixture and one or more cyclodextrin derivatives soluble in the organic water-miscible organic solvent or solvent mixture. In some embodiments, the composition comprises one or more compounds. The invention is further directed to capsules containing the compositions ... 05/18/06 - 20060105044 - Sustained release formulations of sotalol Sustained release compositions of sotalol, or a pharmaceutically acceptable salt thereof, are provided. In certain examples, sotalol, or a pharmaceutically acceptable salt thereof, may be administered in an effective amount to provide a therapeutic effect to a patient, such as, for example, a patient suffering from a cardiac disorder. In ... 05/11/06 - 20060099265 - Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C2-8 alkoxyl, substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an ... 05/11/06 - 20060099264 - Polyaminoacids functionalized by alpha tocopherol and uses thereof, particular for therapeutic applications The invention concerns novel biodegradable polyaminoacid materials, useful in particular for vectoring active principle(s). The invention also concerns novel pharmaceutical, cosmetic, dietetic or phytosanitary compositions based on said polyaminoacids. The invention aims at providing a novel polymer raw material, capable of being used for vectoring active principles and enabling optimal ... 05/04/06 - 20060093674 - Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, ... 05/04/06 - 20060093673 - Controlled release of anti-arrhythmic agents Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti-arrhythmia drugs are incorporated along with ... 04/13/06 - 20060078617 - Pharmaceutical compositions for the treatment of cancer This invention relates to novel pharmaceutical compositions comprising a solid dispersion of the compound of Formula I below, to processes for preparing these novel pharmaceutical compositions and to their use for treating hyper-proliferative disorders, such as cancer, either as a sole agent or in combination with other therapies. Formula I ... 04/13/06 - 20060078616 - Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol The present invention provides a pharmaceutical formulation having thermoreversible properties, comprising: a) an anti-microbial agent; b) a poloxamer mixture containing at least two poloxamer polymers; and c) a hydroxy fatty acid ester of polyethylene glycol, wherein the formulation is a solid at room temperature and is a liquid-gel at body ... 03/23/06 - 20060062854 - Hydrogel having anti-microbial properties A method of making a hydrogel having antimicrobial properties. The hydrogel includes a hydrogel-forming polymer and an anti-microbial agent. The method includes mixing a hydrogel-forming polymer, such as a hydrophilic polymer, with water and cross-linking the polymer and water using an energy source. The method does not require any chemical ... 03/23/06 - 20060062853 - Treating neuromuscular disorders with an oral formulation of creatine derivatives Treating human muscle tissue by the oral administration of a formulation of creatine derivative and in particular creatine esters and more particularly ethyl esters of creatine are described. The formulations comprise a phosphate such as dicalcium phosphate, a biodegradable polymer such as a polyvinyl pyrrolidine and a starch. The formulation ... 03/16/06 - 20060057212 - Polyolefin additive composition comprising 3,4-dimethyl dibenzylidene sorbitol and p-methyl dibenzylidene sorbitol and method of using such composition in a polyolefin A specific combination of two different polyolefin clarifying and nucleating agents, namely 3,4-dimethyldibenzylidene sorbitol and p-methyldibenzylidene sorbitol is provided. Such a combination surprisingly provides improved clarification and crystallization temperatures to polypropylene articles and formulations, better than bis-p-methyldibenzylidene sorbitol alone and equivalent or better than 3,4-dimethyldibenzylidene sorbitol. Such a combination of ... 03/16/06 - 20060057211 - Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of ... 03/16/06 - 20060057210 - Controlled release oxycodone compositions A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formulation ... 03/16/06 - 20060057209 - Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating ... 03/16/06 - 20060057208 - Biocompatible drug delivery apparatus and methods Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution ... 03/09/06 - 20060051422 - Stabilised solid drug dispersions in an organic carrier and a process for preparing the same New solid drug dispersions are described in which the drug is present in amorphous form and massively dispersed (in bulk) inside the particles of an organic carrier selected from cross-linked polymers and/or a complexing agents. These dispersions are obtainable by mixing together the drug and the carrier and applying an ... 02/23/06 - 20060039980 - Process of preparing a biodegradable polymer using an enzyme catalyst and a biodegradable polymer prepared through the process Disclosed is a process of preparing a biodegradable polymer using an enzyme catalyst and a biodegradable polymer prepared through the process. The process includes polycondensing a polyhydric alcohol monomer having a secondary hydroxyl functional group and an acid monomer having a dicarboxylic group in the presence of the enzyme catalyst. ... 02/23/06 - 20060039979 - Drug delivery system using subconjunctival depot The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the ... 02/16/06 - 20060034932 - Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions. ... 02/16/06 - 20060034931 - Solvent-assisted loading of therapeutic agents Methods are provided for loading polymeric regions of medical devices with therapeutic agents. In these methods, a polymeric region of a medical device is first pretreated with a solvent system. Subsequently, therapeutic-agent-containing particles are impacted into the pretreated polymeric region at a velocity that is effective to at least partially ... 02/09/06 - 20060029675 - Method for coating substrate with antimicrobial agent and product formed thereby A method for uniformly coating a foam or dressing with antimicrobial polymer incorporating agents, such as silver, and a foam or dressing formed by this process. Such foam or dressing is particularly useful in combination with negative pressure wound therapy. ... 02/09/06 - 20060029674 - Stable amorphous cefdinir The present invention relates to stable amorphous 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer), methods for its preparation, and pharmaceutical compositions comprising stable amorphous 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer). ... 02/09/06 - 20060029673 - Transdermal administration of (r)-3,3-diphenylpropylamin-monoesters The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3 alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, ... 02/02/06 - 20060024371 - Biocompatible material composition adaptable to diverse therapeutic indications A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication. ... 01/26/06 - 20060018967 - Method for treating pipelines A method for treating and sanitizing a pipeline, such as a drinking water line, wherein the pipeline is freed from internal deposits, if any, and then internally covered with a coating material. The coating material may be easily applied to the interior of the pipeline by the disclosed methods, and ... 01/19/06 - 20060013883 - Poloxamer and poloxamine compositions for nucleic acid delivery The invention features selected polymers such as poloxamer 188 (Pluronic® F68), poloxamer 237 (Pluronic® F87), poloxamer 401 (Pluronic® L121), poloxamer 338 (Pluronic® F108), Poloxamer 124 (Pluronic® L44), Poloxamer 184 (L-64), and poloxamines (Tetronics® 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in ... 01/19/06 - 20060013882 - Tri-block copolymers for nanosphere-based drug delivery Biocompatible non-toxic triblock copolymers having an A-B-A structure wherein each A is a hydrophilic, biocompatible end block and the B middle block is a hydrophobic desaminotyrosyl tyrosine polycarbonate or polyarylate. The copolymers spontaneously self-assemble to form low critical aggregation concentration nanospheres having utility as delivery vehicles for hydrophobic biologically or ... 01/19/06 - 20060013881 - Hydrophilic antimicrobial composition for an air conditioner evaporator of a vehicle The present invention relates to a hydrophilic antimicrobial coating composition for an air conditioner evaporator of a vehicle with improved durability. In one embodiment of the present invention, the antimicrobial composition comprises a hydrophilic organic polymer with molecular weight in the range of about 4,000 to 8,000, a smoothing agent, ... 01/19/06 - 20060013880 - Formulation stabilizer for proton pump inhibitors The present invention provides a composition containing a benzimidazole derivative proton pump inhibitor and a polymeric base. The polymeric base is cholestyramine-OH, Eudragit E-PO, chitosan, or a mixture thereof. The composition stabilizes the benzimidazole derivative proton pump inhibitor in a humid environment so that degradation during storage. ... 01/19/06 - 20060013879 - Gel composition and methods Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 ... 01/12/06 - 20060008530 - Tissue matrix system The present application discloses matrix compositions to support the repair of tissue defects such as an osteochondral injury. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. ... 01/12/06 - 20060008529 - Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers A method for increasing, prolonging, and/or controlling the release rates of nitric oxide (NO) from polymeric materials containing NO adducts. Such NO-containing polymeric materials may find use in devices such as blood contacting devices, and biocompatible devices utilizing the same. The method and device utilizes anionic site additives, acidic site ... 01/05/06 - 20060003009 - Slow release protein polymers The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles. ... 01/05/06 - 20060003008 - Polymeric devices for controlled release of active agents Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and ... 12/29/05 - 20050287218 - Biomaterial Biomaterial formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer. ... 12/29/05 - 20050287217 - Transdermal delivery system for water insoluble drugs The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and ... 12/29/05 - 20050287216 - Medical imaging agents for injectable compositions Medically useful compositions, methods and devices comprising insoluble particulate imaging agents are described. The individual particles of the imaging agents of these compositions, methods and devices exhibit regular, smooth morphologies and uniform particle size distributions that allow for enhanced endovascular delivery of the compositions to a mammalian body. ... 12/22/05 - 20050281880 - Methods for making injectable polymer hydrogels Methods for preparing injectable hydrogels, particularly hydrogels containing hyaluronan, are described herein. Also described are hydrogel products made by the methods provided herein. ... 12/22/05 - 20050281879 - Excipients in drug delivery vehicles Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form ... 12/22/05 - 20050281878 - Process The present invention provides a process for the preparation of a functionalised porous material comprising the steps of sintering polymer components to provide a porous substrate and grafting a chemical species selected from a molecularly imprinted to polymer and a functionalised moiety onto the porous substrate to provide the functionalised ... 12/15/05 - 20050276857 - Hydrogels formed by non-covalent linkages In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent ... 12/15/05 - 20050276856 - Non-aqueous single phase vehicles and formulations utilizing such vehicles The present invention is related to materials and methods for forming polymeric delivery vehicles that reduces risk of oxidative degradation of a carried drug and the resulting compositions. ... 12/15/05 - 20050276855 - Composition and method using local application of lipophilic lathyrogens sustained release formulations A method is disclosed to treat a patient having a wound in a tissue structure, where the wound is defined by a wound line, by inhibiting the crosslinking of collagen during the healing of that wound. The method provides a lipophilic lathyrogen, and injects that lipophilic lathyrogen into the tissue ... 12/08/05 - 20050271727 - Biodegradable and biocompatible crosslinked polymer hydrogel prepared from pva and/or peg macromer mixtures Biodegradable and biocompatible polymeric hydrogels based on the mixtures of poly(vinyl alcohol) and poly(ethylene glycol) macromers, and methods for their preparation and use, are disclosed. The polymerization may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked hydrogels include prevention of ... 12/08/05 - 20050271726 - Immune enhancing compositions and methods of use thereof A method of administering parenterally, particularly intramuscularly, glutamine and cystine and glycine plus selenium; or lactalbumin plus selenium; or lactalbumin and glutamine and cystine and glycine plus selenium, through a long-acting pharmaceutically acceptable carrier to a patient. The method comprises injecting a mixture of glutamine, cystine, glycine, lactalbumin and selenium ... 12/08/05 - 20050271725 - Adhesive gel composition for iontophoresis preparation and process for producing the same The present invention provides an adhesive gel composition for iontophoretic formulations which is useful for the application through the skin or the mucosa, which excels in all of drug absorption, drug stability, gel shape retention and gel adhesion, which is easy to prepare and fill at the time of production, ... 12/01/05 - 20050266086 - Intrauterine applications of materials formed in situ Certain embodiments herein are directed to method of preventing adhesions in a uterus by introducing a flowable material into a uterus to tamponade a surface of the uterus. Such a material may be a hydrogel. The hydrogel may be formed in situ from at least one precursor, for example, a ... 12/01/05 - 20050266085 - Gelled emulsion and microemulsion formulations for dermal drug delivery The present invention is drawn to gelled emulsion and microemulsions formulations for dermal drug delivery, including transdermal drug delivery. In one embodiment, a drug-containing gelled emulsion can comprise a continuous gelled aqueous phase, and a discontinuous drug-containing oil phase dispersed within the continuous gelled aqueous phase, wherein the drug-containing gelled ... 12/01/05 - 20050266084 - Modified release dosage forms In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches ... 11/24/05 - 20050260270 - Inhibition of gene expression by delivery of small interfering rna to post-embryonic animal cells in vivo A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of ... 11/24/05 - 20050260269 - Composition containing nano-crystalline apatite This invention describes compositions containing nano-crystalline apatite useful as bone—or preferably as tooth restorative materials. The materials produced, using the composition have improved properties in the areas of esthetics, hardness, translucency, surface polishability, strength and the capability to release and to take ions up in respect of a biological environment. ... 11/17/05 - 20050255161 - Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water A stabilized pharmaceutical composition that comprises a pharmaceutical compound that is labile to degradation in the presence of water is disclosed. That composition contains water, an effective amount of labile pharmaceutical compound and a degradation-inhibiting amount of a C4-C12 polyol that is substantially free of aldehyde or ketone carbonyl groups. ... 11/17/05 - 20050255160 - Polymide resin dermal composition A gel composition made from a polyamide resin combined with an lower carboxylic acid or anhydride alkyl amide; the compositions are suitable for making attractive topically-applied cosmetic, topical fragrance and topical dermatology drug products in translucent gel form. ... 11/03/05 - 20050244501 - Water-soluble stabilized self-assembled polyelectrolytes The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. ... 11/03/05 - 20050244500 - Intravitreal implants in conjuction with photodynamic therapy to improve vision A method for treating a posterior ocular condition so as to improve vision is provided. The method includes the steps of placing into an eye, a bioerodible implant comprising an anti-inflammatory component and a bioerodible polymeric component, introducing a photoactive agent into the eye, and irradiating the eye with electromagnetic ... 10/27/05 - 20050238722 - Multiblock biodegradable hydrogels for drug delivery and tissue treatment Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from ... 10/27/05 - 20050238721 - One step compounding extrusion of drug filled polymers The present invention relates to a method for providing an article which contains a pharmaceutical ingredient and a polymeric material. The pharmaceutical ingredient may be melt compounded into the polymeric material and extruded through a profile die to provide a product. ... 10/27/05 - 20050238720 - Stable pharmaceutical composition comprising erythropoietin The present invention provides a new stable pharmaceutical composition of erythropoietin (EPO) that is stabilized with PVP. ... 10/13/05 - 20050226933 - In situ forming hydrogels The invention features materials and methods for the liquid to solid transition of an injectable pre-hydrogel composition to a hydrogel. These methods can be carried out in situ. ... 10/13/05 - 20050226932 - Pharmaceutical formulations for itraconazole The present invention relates to a pharmaceutical composition containing as an active ingredient, itraconazole. More particularly, the present invention relates to the pharmaceutical composition comprising itraconazole, a polylactic acid derivative, and an amphiphilic block copolymer. The polylactic acid derivative may be combined with a metal ion at the carboxylic acid ... 10/13/05 - 20050226931 - Silver-containing compositions, devices, and methods for making The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any ... 10/06/05 - 20050220881 - Pharmaceutical composition The present invention provides a composition including an association complex of a pharmaceutical composition and one or more polyethylene-polypropylene glycol block co-polymers (poloxamers). The pharmaceutical composition may include a member selected from the group consisting of (a) an association complex of an eprosartan composition including eprosartan or a pharmaceutically acceptable ... 10/06/05 - 20050220880 - Drug carriers comprising amphiphilic block copolymers An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug, for instance having ... 09/29/05 - 20050214376 - Hydrogel-containing medical articles and methods of using and making the same Medical articles including a hydrophilic water-swellable hydrogel and methods of using and making the articles are provided. The hydrogel may include a crosslinked mixture of a biocompatible polymer and a protein, such as polyethylene glycol and a soy protein. The hydrogel may further include an agent, such as diazolidinyl urea ... 09/29/05 - 20050214375 - Process for producing block copolymer/drug composite A process for producing a block copolymer-drug composite that can be industrialized, wherein neither dialysis nor ultrafiltration is performed and wherein halogenated hydrocarbons are not used. The process for producing a block copolymer-drug composite is characterized by comprising the steps of dissolving an AB type block copolymer composed of hydrophilic ... 09/22/05 - 20050208138 - Local regional chemotherapy and radiotherapy using in situ hydrogel Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polyamino acid, with a therapeutic agent, such as a radionuclide or a ... 09/22/05 - 20050208137 - Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions. ... 09/22/05 - 20050208136 - Antitumor agent and process for producing the same The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA) and low molecule antitumor agent which is anthracyclins drug such as pirarubicin, doxorubicin, epirbicin, daunorbicin, acralbicin, or alkaloid antitumor agent such as cis-platinum, ... 09/15/05 - 20050202091 - Stable pharmaceutical composition comprising erythropoietin The present invention provides a new stable pharmaceutical composition of erythropoietin (EPO) that is stabilized with a combination of a poloxamer polyol and a polyhydric alcohol. ... 09/15/05 - 20050202090 - Novel pharmaceutical dosage forms and method for producing same Pharmaceutical dosage forms are produced by injection molding a mixture of an agent and a polymer under pressure, in the presence of a gas or supercritical fluid. Rapid release of the pressure causes the mixture to form a microcellular or supermicrocellular solid. The release of pressure takes place in the ... 09/08/05 - 20050196452 - Surface directed cellular attachment Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of ... 09/08/05 - 20050196451 - Tolperisone-containing pharmaceutical preparation with controllable active-substance release for oral administration The invention relates to a tolperisone-containing pharmaceutical preparation with controllable active-substance release for oral administration, characterised in that the active substance tolperisone and/or a pharmaceutical salt thereof is embedded in a pharmaceutically compatible material. By selecting the pharmaceutically compatible materials in the preparation and accordingly in the coating of a ... 09/08/05 - 20050196450 - Method and composition for burned skin This invention relates to compositions, methods and delivery systems for application on burns and surrounding tissue wherein said composition comprise ammonium hydroxide (or ammonium bicarbonate) and /or 15-70% volatile short chain mono-alcohols. ... 09/08/05 - 20050196449 - Embolization Embolization, as well as related particles, compositions, and methods, are disclosed. ... 09/01/05 - 20050191355 - Anti-microbial and antifungal fluid conduits and methods of manufacture thereof Antimicrobial/antifungal fluid conduits (are extruded, co-extruded, molded and/or otherwise thermoformed or thermoset), and films formed on non-thermoplastic conduit walls. One or more inorganic antimicrobial agents are selectively dispersed and concentrated near a surface at which antimicrobial/antifungal properties are desired. The agents resist wear from repeated fluid flows through embedding in ... 09/01/05 - 20050191354 - Promoting cell regeneration and/or cell differentiation with non-metabolizable sugar and a polymeric absorbent A composition comprising at least one absorbent and at least one non-metabolizable sugar, and a method for using the composition, for promoting cell regeneration and/or cell differentiation. ... 08/25/05 - 20050186280 - Method for stabilizing a composition having a biologically active epidermal growth factor as an active ingredient A method for stabilizing a composition having a biologically active EGF as an active ingredient includes the step of adding a carboxyvinyl polymer as a stabilizer of the EGF. The content of the EGF is within the range of 0.1 to 1000 μg/g on the basis of the total weight ... 08/18/05 - 20050181056 - Insect and microorganism control for buildings The intrusion of insects into a home or similar building is controlled by utilizing insect and/or microorganism controlling plastic materials in the construction of the building. The insect and/or microorganism controlling plastic building materials are manufactured by first blending one or more plastic resins with one or more insect and/or ... 08/18/05 - 20050181055 - Pharmaceutical compositions of quinapril The present invention relates to pharmaceutical compositions of quinapril and processes for their preparation. One pharmaceutical composition includes a therapeutically effective amount of quinapril or an acid addition salt thereof and between about 15% w/w to about 40% w/w of an alkaline substance. ... 08/11/05 - 20050175704 - Polyacrylamide hydrogel as a soft tissue filler endoprosthesis A hydrogel is obtained by combining acrylamide and methylene bis-acrylamide, radical initiation and washing with pyrogen-free water or saline solution to give less than 3.5% by weight polyacrylamide, based on the total weight of the hydrogel. The hydrogel may be used as a soft tissue filler endoprosthesis. Also disclosed is ... 08/11/05 - 20050175703 - Polymer compositions and methods for their use Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss. ... 08/11/05 - 20050175702 - Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis and therapy The invention relates to thermosensitive polymers which contain magnetic and/or metallic colloids and whose physical structure can be altered through magnetic induction or through the supply of energy. The invention also relates to processes for the production of such thermosensitive polymers, and the use of such polymers for diagnostic and ... 08/04/05 - 20050169998 - Stabilizing cgmp in aqueous formulation A cGMP containing aqueous composition exhibiting a reduced off-flavor even after extended storage, comprising a hydrophobic resin; and an agent, that chemically blocks functional groups in cGMP. Methods of preparing and using the product are also provided. ... 08/04/05 - 20050169997 - Method for preparing resinates A highly productive and environmentally friendly method of loading pharmaceutically active substances onto ion exchange resins using a water miscible or water-immiscible solvent is disclosed. ... 07/28/05 - 20050163856 - Abuse-resistant sustained-release opioid formulation A method for reducing the abuse potential of an oral dosage form of an opioid extractable by commonly available household solvents said method comprising combining a therapeutically effective amount of the opioid compound, or a salt thereof, a matrix-forming polymer and an ionic exchange resin. ... 07/28/05 - 20050163855 - Method of preparing low-crystallinity oltipraz or amorphous oltipraz Provided is a method of preparing low-crystallinity oltipraz or amorphous oltipraz. The method includes: obtaining a mixed solution containing oltipraz and a water-soluble polymer or a water-insoluble polymer in a solvent, the solvent being an organic solvent or purified water; and solid-dispersing the oltipraz in the polymer. In the solid-dispersing, ... 07/28/05 - 20050163854 - Antimicrobial composites, films, labelstocks and labels This invention relates to antimicrobial composites, films, labelstocks and labels. The antimicrobial composites comprise a mixture of (A) a terpolymer prepared from a mixture comprising (i) an olefin, (ii) at least one copolymerizable comonomer comprising ethylenically unsaturated organic acids or esters, vinyl esters of saturated carboxylic acids and mixtures of ... 07/28/05 - 20050163853 - Novel biomaterials their preparation and use The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anonic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: contacting the anionic polymeric component and ... 07/28/05 - 20050163852 - Process for loading and thermodynamically activating drungs on polymers by means of supercritical fluids The present invention refers to a process of loading drugs in a thermodynamic activated form into polymers by means of supercritical fluids. The process includes a pre-treatment step of the cross-linked polymer with pure supercritical fluid to allow a higher degree and a more rapid kinetic of drug loading into ... 07/21/05 - 20050158387 - Olopatadine formulations for topical administration Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations. ... 07/21/05 - 20050158386 - Process for producing a pharmaceutical solid preparation containing a poorly soluble drug Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in ... 07/07/05 - 20050147684 - Composition for delivery of hematopoietic growth factor A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first ... 07/07/05 - 20050147683 - Composition for delivery of hematopoietic growth factor A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first ... 07/07/05 - 20050147682 - Composition for delivery of hematopoietic growth factor A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first ... 07/07/05 - 20050147681 - Multi-arm block copolymers as drug delivery vehicles The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an ... 07/07/05 - 20050147680 - Injectable veterinary composition for small animals An injectable aqueous composition for veterinary use containing a non-steroidal anti-inflammatory compound in an amount of from about 0.25 to 30% (w/v) together with a physiologically acceptable oxygenated polymeric surfactant in an amount of from about 0.5 to 20% (w/v). ... 06/23/05 - 20050136114 - Taste masked pharmaceutical compositions comprising bitter drug and ph sensitive polymer The present invention discloses pharmaceutical compositions comprising of pH sensitive polymers used for taste masking highly bitter drugs. The pH sensitive polymer acts as a reverse enteric coating, which is soluble in the acidic pH range 1.0 to 3.0 normally found in the stomach but is insoluble in the pH ... 06/16/05 - 20050129770 - Ophthalmic compositions containing a pva/borate gelling system Ophthalmic compositions containing a polyvinyl alcohol/borate gelling system are described. The system forms a gel or partial gel when the composition is applied to the eye. The compositions are particularly useful as ocular lubricants or artificial tears. ... 06/16/05 - 20050129769 - Polymeric articles for carrying therapeutic agents Hydrophilic polymeric nanoarticles comprising a polymeric scaffold and one or more therapeutic agents, such as drug or drug-conjugate molecules, covalently attached to the scaffold. The articles may further optionally comprise recognition elements (REs) that bind to biomolecular structures expressed on certain cells or in certain tissues, to facilitate targeting and/or ... 06/16/05 - 20050129768 - Pharmaceutical formulation containing an ltb4-antagonist, as well as processes for the preparation thereof and the use thereof wherein A, R1, R2, R3 and R4 are defined as in claim 1, the pharmacologically acceptable acid addition salt, glycoside, O-sulphate or glucuronide thereof as active substance as well as optionally at least one pharmacologically acceptable excipient and/or carrier, the active substance being present as a solid solution or solid ... 06/16/05 - 20050129767 - Antifungal formulation and manufacturing method thereof A new antifungal formulation is provided. The present invention uses a sterol modified with polyethylene glycol (PEG) as a drug carrier. The drug carrier encapsulates Amphotericin B (AmB) by self-assembly to form polymeric micelles. The polymeric micelles can reduce toxicity of Amphotericin B and control release of Amphotericin B. The ... 06/16/05 - 20050129766 - Antimicrobial composition This invention relates to an antimicrobial composition comprising an antimicrobial compound and a polyethylene-polyvinylalcohol copolymer. It further relates to a medium having antimicrobial properties comprising a support and a layer comprising an antimicrobial composition comprising an antimicrobial compound and a polyethylene-polyvinylalcohol copolymer. ... 06/02/05 - 20050118271 - Polytartrate composition The invention provides a polytartrate composition for pulsatile release of a pharmaceutically active material that is in the form of a compressed tablet, and a process for preparing such a composition. ... ### FreshPatents.com Support |