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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Tablets, Lozenges, Or Pills > Sustained Or Differential Release Type > Layered Unitary Dosage Forms Layered Unitary Dosage FormsLayered Unitary Dosage Forms patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/02/07 - 20070178156 - Pharmaceutical formulations The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug ... 07/19/07 - 20070166380 - Zolpidem tablets A zolpidem tablet having modified release is designed as a tablet-in-tablet dosage form. ... 07/19/07 - 20070166379 - Coated tablet containing venlafaxin or its salts with controlled release A venlafaxin containing coated tablet with controlled release, which contains venlafaxin, or its salt with an inorganic or carboxylic acid, in amounts from 20 to 60 weight %, and a hydrophilic polymer in amounts from 30 to 70 weight %, based on the weight of the core, in its core, ... 07/12/07 - 20070160670 - Compression-coated tablets and manufacture thereof Tablets for the treatment of migraine comprise a core, containing the active agent sumatriptan or a pharmaceutically-acceptable salt or ester thereof, and a mantle, free of sumatriptan. Tablets are prepared by compressing mantle components, free of the active agent, around a partially-compressed, active-containing core. ... 07/05/07 - 20070154551 - Coating method The present invention concerns a method for coating granules comprising mesalazine, with a coating mixture comprising two polymers, polymer I and polymer II; said polymer I being selected to allow formation of a closing membrane around said granules in the absence of said polymer II, and said polymer II being ... 07/05/07 - 20070154550 - Pharmaceutical composition comprising anticonvulsant with taste mask coating A pharmaceutical composition in the form of coated core particles comprising an anticonvulsant drug, which can be sprinkled onto food, wherein said core particles are coated with a taste mask coating which is less than 7% by weight of the pharmaceutical composition. ... 06/28/07 - 20070148241 - Use of an intermediate for controlling the release profile of an oral formulation of a medicament A swellable intermediate layer that includes a swellable material selected from the group of starch, starch derivatives such as pregelatinised starch, sodium carboxyethyl starch, sodium starch gycolate, cellulose, cellulose ethers such as HPMC, HPC, HEC MC, sodium carboxymethyl cellulose, carrageenans, aginates, pectins, xanthanes and their derivatives, guar gum, tragacanth, polyvinyl ... 06/28/07 - 20070148240 - Oral formulation containing itraconazole and methods for manufacturing and using the same The present invention provides oral pharmaceutical formulation for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The oral pharmaceutical formulation contains a core and a drug coating layer. The drug coating layer contains the azole antimicrobial drug and a binder, but not containing an emulsion (such as polyoxypropylene-polyoxyethylene ... 06/21/07 - 20070141155 - Pharmaceutical tablets having height greater than width An immediate release compressed pharmaceutical tablet that has two or more segments and a top and a bottom and has a height that exceeds the width of the tablet. The height is measured vertically from the top to the bottom of the tablet while it is in the tablet die ... 06/21/07 - 20070141154 - Antidiabetic formulation and method An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in the formulation so that the glipizide does not hydrolyze, yet the metformin is compressible, if necessary. A method for treating diabetes is ... 06/21/07 - 20070141153 - Orally administered pharmaceutical composition An object of the present invention is to provide an orally administered pharmaceutical composition comprising a drug-containing layer and a functional layer wherein cracks and gaps in the drug-containing layer are prevented even if the amount of glycerin contained in the drug-containing layer is not sufficient to cause bleeding of ... 06/21/07 - 20070141152 - Orally administered pharmaceutical composition It is an object of the present invention to provide an orally administered pharmaceutical composition capable of completely masking the flavor, odor and the like of a drug contained in a drug-containing layer, and to achieve this object, the outer edge of a first water-swellable gel-forming layer 12a and the ... 06/21/07 - 20070141151 - Lansoprazole orally disintegrating tablets The invention provides orally disintegrating tablets that readily disintegrates in the mouth, releasing enteric coated drug sub-tablets. ... 06/21/07 - 20070141150 - Pharmaceutical composition A solid pharmaceutical dosage form comprises a core particle containing at least one pharmaceutical active ingredient and/or excipient that is sensitive to acid, a subcoating containing a chemically reactive component disposed over the core, and an enteric coating over the subcoating. ... 06/14/07 - 20070134331 - Orodispersible pharmaceutical composition for oromucosal or sublingual administration of agomelatine The invention relates to a coated solid orodispersible pharmaceutical composition for the administration of agomelatine by the oral, oromucosal or sublingual route. ... 06/14/07 - 20070134330 - Methods and compositions for improved image quality The present invention is directed to consumable coating compositions for use on consumable products, such as pharmaceutical products (e.g., tablets, pills, capsule, gel cap, caplet). ... 06/07/07 - 20070128279 - Extended release dosage form A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form ... 06/07/07 - 20070128278 - Pharmaceutical formulations The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid. ... 06/07/07 - 20070128277 - Coated tablets The invention relates to coated tablets comprising the pharmaceutically active substance diclofenac. Said tablets are characterized by a special, very beneficial coating based on hydroxypropyl methylcellulose. ... 05/31/07 - 20070122481 - Modified release compositions comprising a fluorocytidine derivative for the treatment of cancer The invention relates to a multiparticulate modified release composition comprising a fluorocytidine derivative, preferably capecitabine, and a modified release component comprising a modified release coating, a modified release matrix material, or both. Following oral delivery, the composition in operation delivers the fluorocytidine derivative in a pulsatile manner at about six ... 05/31/07 - 20070122480 - Sustained release formulations Provided is a sustained-release formulation: (a) a sustained-release core including an active ingredient and a polymer having erosion and swelling property in mammalian intestinal secretions, (b) an enteric film coating layer coated on the sustained-release core, and (c) an active ingredient-containing film coating layer coated on the enteric film coating ... 05/24/07 - 20070116764 - Method for treatment of solid pharmaceutical preparation prior to printing and solid pharmaceutical preparation subjected to treatment prior to printing The present invention provides a method for treating a solid dosage form to improve the printability and abrasion resistance of a print to be produced on a surface of the solid dosage form, which includes treating the surface of the solid dosage form with a polyethylene glycol-containing aqueous solution before ... 05/17/07 - 20070110807 - Delayed release tablet with defined core geometry A press-coated tablet comprising a core containing an drug substance, and a coating, the core being disposed within the coating such that the coating has a first thickness about an axis A-B and a thickness about an orthogonal axis X-Y, such that the coating about the axis X-Y is thicker ... 05/10/07 - 20070104789 - Gastro-resistant and ethanol-resistant controlled-release formulations comprising hydromorphone The invention provides a controlled-release composition comprising hydromorphone or a pharmaceutically acceptable form thereof in association with a gastro-resistant and ethanol-resistant compound and method of use thereof. ... 05/03/07 - 20070098797 - Modified release composition of at least one form of venlafaxine The present invention relates to a modified release composition of at least one form of venlafaxine, which is a delayed controlled release composition. The composition comprises a core comprising at least one form of venlafaxine selected from the group consisting of venlafaxine, an active metabolite of venlafaxine, a pharmaceutically acceptable ... 04/26/07 - 20070092569 - Extended release formulation of levetiracetam The present invention relates to extended release pharmaceutical compositions of Levetiracetam and processes for preparing the same. The extended release tablet of Levetiracetam is with a core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of water non-dispersible ... 04/26/07 - 20070092568 - Galantamine compositions The present invention relates to controlled release compositions of galantamine, processes to prepare the compositions, their in-vitro release profiles and method of use and method of treatment using the said compositions. ... 04/19/07 - 20070087057 - Hydrogel-driven drug dosage form A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least ... 04/19/07 - 20070087056 - Pharmaceutical form with sustained ph-independent active ingredient release for active ingredients having strong ph-dependent solubility Solid pharmaceutical formulation for a sustained pH-independent active ingredient release comprising at least one layer of one or more water-insoluble polymers, at least one layer of one or more pH-dependently water-soluble polymers and an active ingredient-containing core, having strong pH-dependent water solubility and comprises at least one osmagent. ... 04/05/07 - 20070077300 - Oral compositions containing a salivation inducing agent Oral dosage forms, and particles used therein, containing salivation inducing agents are disclosed. The salivation agents may be in the core of the dosage form and/or in coatings applied thereto, or alternatively may be within particles and/or the matrix of such dosage forms, in coatings applied to such particles, or ... 04/05/07 - 20070077299 - Oral formulation for 5-ht-receptor agonists, uses and methods of treatment employing the same A pharmaceutically acceptable oral formulation comprising core material which comprises a therapeutically effective amount of a 5-HT-receptor agonist, or a pharmaceutically acceptable salt, solvate or derivative thereof, which core material is provided with a substantially water resistant coating comprising one or more substantially water resistant materials. ... 03/01/07 - 20070048380 - Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof The invention relates to a stable medicament for oral administration which comprises (a) a core which contains an active ingredient selected from Omeprazole, Lansoprazole and Pantoprazole, together with customary pharmaceutical adjuvants, (b) an intermediate layer applied onto the core, and (c) a gastric juice-resistant outer layer. The intermediate layer in ... 03/01/07 - 20070048379 - Valproate tablet A process for preparing a pharmaceutical tablet comprising: (a) mixing a valproate compound with at least one excipient to form a premix; (b) adding a sufficient amount of water to the premix of Step (a) and mixing to form a wet granulation; (c) drying the wet granulation of Step (b) ... 02/22/07 - 20070042045 - Multilayer dosage form comprising a matrix that influences release of a modulatory substance d) an outer controlling layer comprising at least 60% by weight of one or a mixture of a plurality of (meth)acrylate copolymers composed of 98 to 85 C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 15% by weight of methacrylate monomers with a quaternary ammonium group in ... 02/22/07 - 20070042044 - Matrix compositions for controlled delivery of drug substances A novel matrix composition for pharmaceutical use. The matrix composition has been designed so that it is especially suitable in those situation where an improved bioavailability is desired and/or in those situation where a slightly or insoluble active substance is employed. Accordingly, a controlled release pharmaceutical composition for oral use ... 02/15/07 - 20070036863 - Oxacarbazepine film-coated tablets The invention relates to formulations, e.g. film-coated tablets containing oxcarbazepine and to processes for the production of said formulations. The film-coated tablets have a tablet core comprising a therapeutically effective dose of oxacarbazepine being in a finely ground form having a mean particle size of from 4 to 12 μm ... 02/15/07 - 20070036862 - Treatment with azetidinone-based cholesterol absorption inhibitors and omega-3 fatty acids and a combination product thereof Combinations of one or more azetidinone-based cholesterol absorption inhibitors with mixtures of omega-3 fatty acids, methods of administering such combinations, and unit dosages of such combinations. ... 02/15/07 - 20070036861 - Orally-dispersible multilayer tablet The present invention relates to a multilayer orodispersible tablet and to the process for preparing it. ... 02/08/07 - 20070031494 - Method of administering a partial dose using a segmented pharmaceutical tablet A method for providing partial doses of a drug or drugs is disclosed. The method includes breaking of a tablet configured to have an active layer as a first segment and an inactive support layer or substrate as a second segment, or breaking a layered tablet through a first active ... 01/25/07 - 20070020334 - Benzimidazole formulation A dry manufacturing process for the production of a pharmaceutical formulation of a benzimidazole and an alkaline substance is described. A tablet is compressed directly from a dry powder or a dry particulate matter avoiding any liquid or excipient conventionally used as a wet binder. The manufacturing process has the ... 01/11/07 - 20070009599 - Asymmetrically coated table A tablet for the controlled release of a drug. The tablet is in the form of an asymmetrically coated tablet so that immediate release or time-delayed release times can be precisely controlled and the extended release slab may provide zero-order or first-order extended release and pulsatile release depending on the ... 01/04/07 - 20070003623 - Formulations of conjugated estrogens and bazedoxifene The present invention relates to solid dosage formulations containing conjugated estrogens and bazedoxifene, or a salt thereof. In some embodiments, the compositions include a core comprising conjugated estrogens, and at least one coating that comprises bazedoxifene, or a salt thereof. ... 01/04/07 - 20070003622 - Diphenhydramine containing dosage form A pharmaceutical dosage form which comprises diphenhydramine and/or a pharmaceutically acceptable salt thereof. The dosage form is capable of providing a diphenhydramine plasma concentration within a therapeutic range for at least about 24 hours per single dose. This Abstract is neither intended to define the invention disclosed in this specification ... 12/14/06 - 20060280795 - Specific time-delayed burst profile delivery system The invention provides a delivery device for the delayed release of an active agent in the gastrointestinal tract comprising a core, comprising an active agent; a first outer coating, comprising a relatively hydrophobic substantially water insoluble polymer having substantially water insoluble hydrophilic particles embedded therein; and a first inner coating ... 12/14/06 - 20060280794 - Solid pharmaceutical preparation A solid preparation comprising an insulin sensitizer and an HMG-CoA reductase inhibitor without deteriorating the stabilities of these drugs, wherein said preparation comprises particles containing an insulin sensitizer and particles containing an HMG-CoA reductase inhibitor. ... 11/30/06 - 20060269606 - Cores and microcapsules suitable for parenteral administration as well as process for their manufacture Process for producing parenterally administrable cores. The cores are intermediates suitable for manufacturing sustained release preparations. Microcapsules incorporating a core and a shell and pharmaceutical compositions incorporating such cores and microcapsules are also provided. ... 11/30/06 - 20060269605 - Multilayer pharmaceutical dosage form containing a substance that acts in a modulatory manner with regard to the release of active substances The invention relates to a multilayer pharmaceutical dosage form for the controlled release of active substances, containing: a) a core layer containing a substance that acts in a modulatory manner with regard to the release of active substances, optionally a neutral core and/or an active substance; b) an inner control ... 11/09/06 - 20060251723 - Formulations of a src/abl inhibitor The invention relates to pharmaceutical compositions of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, and to methods of using the pharmaceutical compositions in the treatment of oncological and immunological disorders ... 11/09/06 - 20060251722 - Multi-component vitamin and mineral supplement for the optimal absorption of components The present invention relates to compositions and methods for administration of vitamin-mineral supplements, including those given to women prenatally. A multi-component vitamin delivery system is described comprising a first layer able to release a first set of components at a first location in the gastrointestinal tract, the first set of ... 11/02/06 - 20060246136 - Systems, methods and apparatuses for manufacturing dosage forms Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, injection molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via a transfer device, into an overall system ... 10/26/06 - 20060240108 - Cellulosic films incorporating a pharmaceutically acceptable plasticizer with enhanced wettability An enteric coating for a solid pharmaceutical carrier or substrate wherein the enteric coating includes a cellulosic polymeric material selected from selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose acetate phthalate, cellulose acetate succinate, cellulose ... 10/26/06 - 20060240107 - Controlled-release compositions A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is ... 10/26/06 - 20060240106 - Enteric coated composition comprising prostaglandin analogs as chloride channel opener The present invention provides an enteric coated composition for oral administration of a chloride channel opener which can provide improved pharmaceutical activity with reduced adverse side effect such as nausea. ... 10/19/06 - 20060233881 - Modified release dosage form The present invention relates to a medicinal dosage form having a first core, a second core, and a shell that surrounds a first portion of each core and a fill material that covers a second portion of at least one core, wherein the fill material that is provided over at ... 10/12/06 - 20060228415 - Modified release tablet of bupropion hydrochloride A modified-release tablet of bupropion hydrochloride comprising (i) a core comprising an effective amount of bupropion hydrochloride, a binder, a lubricant; and (ii) a control releasing coat surrounding said core; and (iii) a moisture barrier surrounding said control releasing coat, wherein the modified-release tablet is bioequivalent to Wellbutrin® or Zyban®/Wellbutrin®SR ... 10/05/06 - 20060222709 - Metformin methods and formulations for treating chronic constipation The present invention is directed to methods and formulations for treating chronic constipation. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of metformin for treating chronic constipation and further comprise at least one pharmaceutically acceptable ingredient to control the release of ... 09/21/06 - 20060210632 - Sublingual coated tablet of fentanyl The present invention relates to a fentanyl coated tablet and to the method for the preparation thereof. ... 09/14/06 - 20060204577 - Pharmaceutical compositions of drugs and neutralized acidic polymers Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed. ... 09/14/06 - 20060204576 - Multilayer dosage forms, which contain active substances and which comprise a neutral core, and an inner and outer coating consisting of methacrylate copolymers and methacrylate monomers The invention relates to a multilayer dosage form comprised of: a) a neutral core; b) an inner coating consisting of a methacrylate copolymer; c) an outer coating consisting of a copolymer of which 40 to 95% by weight is composed of radically polymerized C1 to C4 alkyl esters of acrylic ... 08/31/06 - 20060193915 - Compression coated tablets A pharmaceutical composition for oral administration comprising a compression coated solid dosage form of a bitter or unpleasant tasting pharmaceutically active agent. Included are compression coated oral dosage forms of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide or a pharmaceutically acceptable salt or solvate thereof as active ingredient. The compression coated solid dosage forms are of ... 07/27/06 - 20060165797 - Dosage form for treating gastrointestinal disorders The present invention is directed to drug dosage forms that can be used to treat diseases characterized by abnormal gastric acid secretion. The dosage forms have a core containing a proton pump inhibitor surrounded by an enteric coating or multiple particles containing proton pump inhibitor, each particle being surrounded by ... 07/27/06 - 20060165796 - Extended release formulation of levetiracetam An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam is with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of ... 07/27/06 - 20060165795 - Medicinal compositions comprising a core and a film based on modified cellulose derivatives A medicinal composition comprising: (a) a core in combination with a medicinally effective unit dose of one or more active medicaments; (b) the core being enclosed within a non-expanded film material comprising a modified cellulose material. ... 07/27/06 - 20060165794 - Spheroids, preparation method thereof and pharmaceutical compositions The invention relates to a directly-compressible gastro-resistant spheroid. The spheroid comprises: (i) a core containing one or more active substances; (ii) a flexible, deformable film which directly coats the aforementioned core and which comprises an enteric polymer and a mixture of saturated and/or unsaturated polyglycosylated glycerides, the fatty acids of ... 07/20/06 - 20060159762 - Stable pharmaceutical composition comprising an active substance in the form of solid solution The present invention relates to a novel pharmaceutical comprising an active substance in the form of solid solution. The stability of active substance in the pharmaceutical composition is significantly improved relative to the stability of non-formulated active substance. ... 07/20/06 - 20060159761 - Stable extended release oral dosage composition A film-coated extended release solid oral dosage composition containing a nasal decongestant, pseudoephedrine or salt thereof, e.g., pseudoephedrine sulfate in a core effective to provide a geometric maximum plasma concentration of pseudoephedrine of about 345 ng/mL to about 365 ng/mL at a time of about 7.60 hrs to about 8.40 ... 07/20/06 - 20060159760 - Drug composition having active ingredient adhered at high concentration to spherical core Granule, fine particle or tablet of excellent leaching property, comprising a drug active ingredient in high content realized by forming a layer containing drug active ingredient on core particles through a combination of a method of dispersing and adhering an active ingredient while spraying or adding a binder with a ... 07/20/06 - 20060159759 - Tablet containing water-absorbing amino acid The present invention provides a tablet which comprises a water-absorbent amino acid and a coating agent which is soluble in ethanol and hardly soluble in water. The tablet of the present invention is useful as amino acid preparations for sports, dieting, or pharmaceuticals, and also useful as nutritional supplements, pharmaceuticals ... 07/20/06 - 20060159758 - Coating composition for taste masking coating and methods for their application and use The present invention relates to coating compositions for taste masking and methods for applying the coating compositions to dosage forms to mask the taste of a medicinal substance. The taste masking coating compositions generally include a copolymer of acrylate and methacrylate with a quaternary ammonium group in combination with sodium ... 06/29/06 - 20060141037 - Bilayer tablets of oxcarbazepine for controlled delivery and a process of preparation thereof Bilayer tablet comprising an immediate release first layer comprising an effective amount of oxcarbazepine and at least one pharmaceutically acceptable excipients and a controlled release second layer comprising an effective amount of oxcarbazepine and pharmaceutically acceptable excipients wherein the total amount of oxcarbazepine impurities is less than or equal to ... 06/22/06 - 20060134217 - Leukotriene and integrin inhibitor combination and treatment method The present invention provides novel solid pharmaceutical dosage forms for oral administration comprising a therapeutically active amount of montelukast, or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine-2-(diethylamino)ethyl ester, or a pharmaceutically acceptable thereof, and one or more pharmaceutically acceptable excipients. These novel solid pharmaceutical dosage forms ... 06/22/06 - 20060134216 - Enteric film coating composition containing enteric polymer micronized with detackifier Dry, enteric, film-coating compositions and aqueous dispersions containing the same are disclosed. When applied to orally-ingestible substrates such as oral solid dosage forms, the film coatings are capable of preventing the substrates from disintegrating in media with pH values from about 1 to about 4.5 or higher values. One preferred ... 06/22/06 - 20060134215 - Film coating composition, and coating and tablet of the composition A film coating composition comprises polyvinyl alcohol and talc, and a content of the talc is 50 to 86% by mass based on 100% by mass of the total solid components of the film coating composition. A film consists of the film coating composition, and a tablet comprises the film. ... 06/22/06 - 20060134214 - Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof Disclosed is an enteric coated bead comprising at least one epothilone or epothilone analog; and a capsule comprising a multitude of the enteric coated beads. Also disclosed are a method of preparing the enteric coated bead and a method of treating cancer or other proliferative diseases using the enteric coated ... 06/22/06 - 20060134213 - Stabilized ramipril compositions and methods of making The present invention relates to ramipril compositions with improved stability. More particularly, the present invention is directed to pharmaceutical compositions comprising ramipril that are stabilized against decomposition into degradation products, namely, ramipril-diketopiperazine and ramipril-diacid, during formulation and storage conditions. The present invention also relates to methods for making and methods ... 06/22/06 - 20060134212 - Lercanidipine immediate release compositions The present invention provides an immediate release composition for the low solubility drug, lercanidipine. The immediate release composition of the present invention comprises a core; a first layer, comprising lercanidipine, a surfactant and a binder, and optionally, a second layer comprising a film coating. ... 06/22/06 - 20060134211 - Multi-layer drug delivery device and method of manufacturing same This application relates to a multi-layer drug delivery device and a method of manufacture. The device comprises a substrate; at least one first layer on the substrate containing the drug and a first solvent; and at least one second layer applied to the first layer to regulate release of the ... 06/15/06 - 20060127479 - Solvent free taste masked pharmaceutical compositions A taste masked pharmaceutical composition comprising: (a) a core comprising a bitter tasting drug, such as cetirizine dihydrochloride; and (b) a coating comprising a pharmaceutically acceptable cationic co-polymer based on mono- or dialkylaminoalkyl methacrylate and neutral acrylic or methacrylic esters, wherein the alkyl group independently has 1 to 6 carbon ... 06/15/06 - 20060127478 - Oral dosage formulation A multi-layer oral dosage form, preferably a tablet, comprising a matrix core comprising a therapeutically effective amount of a first drug (NSAID), wherein the matrix core allows sustained release of the first drug; a first layer, which is in contact with the matrix core, comprising a first portion of a ... 05/25/06 - 20060110456 - Method for biocidal and/or biostatic treatment and compositions therefor There is provided a method of biocidal and/or biostatic treatment and compounds and compositions thereof. In particular, there is provided a composition comprising at least one compound having the formula R1R2NR3, wherein R1, R2 and R3, are selected from the group consisting of hydrido, alkyl, aryl, heteroaryl, cycloalkyl, cycloaryl, cycloheteroaryl, ... 05/18/06 - 20060105040 - Pharmaceutical tablet and process for making thereof A pharmaceutical tablet as well as a process for manufacturing the tablet are described herein. More specifically, a tablet and process of manufacture is described where a drug having a defined rate of delivery is applied by compression onto a compressible coating deposited on a tablet having the same or ... 05/11/06 - 20060099262 - Methods and formulations for making controlled release oral dosage form Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. ... 05/11/06 - 20060099261 - Methods and formulations for making controlled release oral dosage form Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. ... 05/11/06 - 20060099260 - Methods and formulations for making pharmaceutical compositions containing bupropion Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. ... 05/11/06 - 20060099259 - Propranolol formulations Controlled-release propranolol formulations comprise a core comprising a pharmaceutically acceptable propranolol salt and an inert core; and a coating disposed on the core, the coating comprising about 70:30 to about 85:15 of ethylcellulose:polyvinylpyrrolidone or about 60:40 to about 75:25 of ethylcellulose:hydroxypropylmethylcellulose. ... 05/11/06 - 20060099258 - Propranolol formulations Controlled-release propranolol formulations comprise a core comprising a pharmaceutically acceptable propranolol salt and a sugar sphere; and a coating disposed on the core, the coating comprising about 70:30 to about 85:15 of ethylcellulose:polyvinylpyrrolidone. ... 05/11/06 - 20060099257 - Controlled drug delivery systems providing variable release rates A controlled release dosage form with variable release rates comprising: 1) a bilayer or multilayer tablet core in which at least one of the layers contains one or more pharmaceutically active ingredients and at least one of the layers contains one or more rate controlling polymers; 2) a substantially insoluble ... 05/04/06 - 20060093672 - Biodegradable oxidized cellulose esters The present invention relates to the preparation of a series of oxidized cellulose esters suitable for use as a drug carrier in the development of biodegradable controlled and/or sustained release pharmaceutical, agricultural, and veterinary compositions, such as films, compacts, microspheres, and pellets. The esters are prepared by acylation of oxidized ... 04/27/06 - 20060088596 - Solubilizing a drug for use in a coating A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is ... 03/30/06 - 20060068011 - Simultaneous encapsulation technique for use in pharmaceutical compositions Multiple active pharmaceutical ingredients may be simultaneously encapsulated into pellets using the melt pelletization technique. The resulting pellets exhibit high active ingredient content and good handling characteristics, such as flowability, lubrication, compression, and size distribution, for production of a solid dosage form of a pharmaceutical composition. A method for preparing ... 03/16/06 - 20060057205 - Phenylepherine containing dosage form A pharmaceutical dosage form which comprises phenylepherine or a pharmaceutically acceptable salt thereof and a second drug. The dosage form provides a plasma concentration within the therapeutic range of the second drug over a period which is coextensive with at least about 70% of the period over which the dosage ... 03/16/06 - 20060057204 - Pharmaceutical compositions containing venlafaxine The invention provides a delayed burst release formulation comprising a core formed as a compressed tablet and an outer coating that surrounds the core; said core comprising venlafaxine, or a pharmaceutically acceptable salt thereof, at least one burst controlling agent and a disintegrant; and said outer coating comprising a water ... 03/16/06 - 20060057203 - Modified release formulations of oxcarbazepine and derivatives thereof Oral once a day dosage forms comprising oxcarbazepine are disclosed. ... 03/16/06 - 20060057202 - Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them A novel patient-convenient, cost effective pharmaceutical composition, comprising of thiazolidinediones and biguanide for controlling hyperglycemia manufactured as multilayer tablet and its process of manufacturing, for immediate release of thiazolidinediones or thiazolidinediones and biguanide and prolonged release of the biguanide only, the tablet comprising of minimum two layers wherein one outer ... 03/09/06 - 20060051421 - Stable pharmaceutical formulations of benzimidazole compounds Provided are stable pharmaceutical formulations of benzimidazole compounds, particularly esomeprazole magnesium, and processes for their preparation. ... 03/09/06 - 20060051420 - Pharmaceutical tablets containing tibolone and a coating The present invention relates to a stabilized pharmaceutical tablet comprising an amount of from 0.1 to 10% by weight of tibolone provided with a coating, such as a film coating, a sugar coating, a sugar film coating or a “wrap” coating. The invention further relates to the use of a ... 03/02/06 - 20060045913 - Controlled-release formulations containing tryptophan or its metabolites New controlled-release formulations containing tryptophan and/or its metabolites are described, as well as the process to obtain them in tablet forms suitable for oral administration in the treatment of pathologies or conditions related to serotonin deficiency in the Nervous System. The formulations are comprised in double-layer tablets, one layer containing ... 02/23/06 - 20060039976 - Controlled release composition using transition coating, and method of preparing same The present invention is concerned with the use of transition coating and transition coating composition to control and or target the release of active pharmaceutical ingredients, and biological, chemical, neutraceutical, agricultural and nutritional materials and a method of preparing controlled release systems utilizing these components. ... 02/16/06 - 20060034928 - Tablet comprising cetirizine and pseudoephedrine The present invention concerns a tablet comprising two distinct segments. More particularly, the invention relates to combinations of two pharmaceutical substances and methods of treatment of allergic disorders. ... 02/16/06 - 20060034927 - Means of delivering drugs in an ascending zero order release pattern Disclosed are dosage forms and methods for sustained release of a drug including: a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is ... 02/09/06 - 20060029671 - Tablet coating composition Disclosed is a method for coating a tablet with a coating composition. The tablet generally comprises a biologically active material, and generally one or more biologically acceptable excipients. The coating composition comprises hemicellulose, partially depolymerized hemicellulose, or a mixture thereof. In preferred embodiments, the coating composition includes a plasticizer, and ... 01/19/06 - 20060013876 - Novel floating dosage form Present invention relates to a novel pharmaceutical composition containing an active ingredient(s) which is retained in the stomach or upper part of gastrointestinal tract for controlled delivery of medicament for improved local treatment, and/or better absorption from upper parts of gastrointestinal tract for effective therapeutic results. Present invention also provides ... 01/05/06 - 20060003007 - Controlled extended drug release technology A controlled extended drug release technology for the controlled extended release of hydrophobic or hydrophilic drugs or therapeutically active agents consisting of a homogeneous blend of one or more therapeutic agents, gas generators and surrounded by one or more layers of coat made of thermoplastic water insoluble cellulose derivatives, acrylic ... 01/05/06 - 20060003006 - Controlled delivery system for bioactive substances A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: at least a biologically active ingredient, and an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend ... 12/22/05 - 20050281875 - Promethazine containing dosage form A pharmaceutical dosage form which comprises promethazine and/or a pharmaceutically acceptable salt thereof. The dosage form is capable of providing a promethazine plasma concentration within a therapeutic range for at least about 24 hours per single dose. This Abstract is neither intended to define the invention disclosed in this specification ... 12/22/05 - 20050281874 - Coating compositions for bitterness inhibition The present invention discloses coating compositions with taste masking property, comprising a blend of pH sensitive polymers and optionally a pH independent polymer or a blend of the pH sensitive polymer and pH independent polymer used for taste masking of highly bitter drugs. The pH sensitive polymers used comprise the ... 12/08/05 - 20050271724 - Sugar coatings and methods therefor Compositions particularly useful as coatings for solid dosage forms of therapeutic agents are provided, as are solid dosage forms comprising such coatings, processes for preparing such solid dosage forms, and the products of those processes. The coating compositions generally provide excellent strength and resistance to cracking, even when applied to ... 12/01/05 - 20050266080 - Coated tablet formulation and method or its HCl salt, which is subject to intra-molecular cyclization, which formulation includes a tablet core containing one or more fillers, and other conventional excipients, which tablet core includes a coating thereon which may include two or more layers, at least one layer of which is an inner seal coat ... 11/24/05 - 20050260267 - Tablets exhibiting reduced drug release variability A compressible extended release tablet or tablet layer having a drug release profile that is not strongly dependent on tablet hardness may be prepared by dry blending a pharmaceutically active ingredient with hydroxypropyl methylcellulose, wherein the hydroxypropyl methylcellulose has a bimodal or multimodal number average molecular weight distribution that includes ... 11/17/05 - 20050255158 - Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night The present invention relates to solid pharmaceutical combinations for oral administration comprising nicotinic acid or a nicotinic acid compound or mixtures thereof in an extended release form and an HMG-CoA reductase inhibitor, which are useful for altering lipid levels in subjects suffering from, for example, hyperlipidemia and atherosclerosis, without causing ... 11/10/05 - 20050249811 - Pharmaceutical compositions for the coordinated delivery of nsaids The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe ... 11/03/05 - 20050244498 - Modified-release compositions of at least one form of venlafaxine The present invention relates to a modified release composition of at least one form of venlafaxine, which is an enhanced absorption delayed controlled release composition for oral administration suitable for once daily dosing. The composition comprises a core comprising at least one form of venlafaxine selected from the group consisting ... 10/27/05 - 20050238719 - Film coating A film coating composition suitable for use in coating pharmaceutical formulations comprising: a) an acrylic polymer, which is Eudragit® NE30D, b) an anti-sticking agent, which is glyceryl monostearate (GMS), c) a surface active agent wherein the surface active agent is in an amount less than 1.3% by weight of the ... 10/27/05 - 20050238718 - Modified-release tablet of bupropion hydrochloride A modified-release tablet of bupropion hydrochloride comprising (i) a core comprising an effective amount of bupropion hydrochloride, a binder, a lubricant; and (ii) a control releasing coat surrounding said core; and (iii) a moisture barrier surrounding said control releasing coat, wherein the modified-release tablet is bioequivalent to Wellbutrin® or Zyban®/Wellbutrin® ... 10/13/05 - 20050226930 - Pain relief composition, method to form same, and method to use same An oral dosage form which includes a bi-layer tablet consisting of an Actives Granulation layer and an Osmagen Granulation layer is disclosed. An encapsulant is disposed over that bi-layer tablet. The encapsulated bi-layer tablet includes an orally therapeutically effective dose of oxycodone in combination with dextromethorphan, where the weight ratio ... 10/06/05 - 20050220877 - Bilayer tablet comprising an antihistamine and a decongestant A pharmaceutical composition in the form of a bilayer tablet comprising: (a) a first discrete portion made with Formulation (A) which comprises a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, and a first carrier base material which provides a sustained-release of the sympathomimetic drug or the pharmaceutically acceptable salt ... 09/29/05 - 20050214373 - Coated tablet formulation and method A coated tablet formulation is provided which includes a medicament such as the PPAR α/γ dual agonist peliglitazar or muraglitazar. The coated tablet includes a tablet core containing one or more fillers, one or more binders, one or more disintegrants, and other conventional excipients, and a coating on the tablet ... 09/29/05 - 20050214372 - Stable pharmaceutical composition comprising an acid labile drug The present invention provides a process of preparing a stable pharmaceutical composition of an acid labile drug such as a pharmaceutically active substituted benzimidazole compound, comprising: a) an inner core coated with the acid labile drug; b) a first intermediate coating devoid of an alkaline stabilizing agent and the benzimidazole ... 09/29/05 - 20050214371 - Stable pharmaceutical composition comprising an acid labile drug The present invention provides a stable pharmaceutical composition of an acid labile drug such as a pharmaceutically active substituted benzimidazole compound, comprising: a) an inner core coated with the acid labile drug; b) a first intermediate coating devoid of an alkaline stabilizing agent and the benzimidazole compound; c) a second ... 09/29/05 - 20050214370 - Stable coating agent comprising sterol An ingestible coating agent comprising: (a) sterol, and (b) solvent. The coating agent can be used to protect ingestible substrates from adverse conditions that would otherwise lead to degradation of the substrate. Preferably, the solvent comprises azeotropic solvent. In another aspect, the present invention provides a coated substrate comprising an ... 09/22/05 - 20050208134 - Biocompatible polymeric beads and use thereof The present invention relates to biocompatible polymeric beads and to biocompatible delivery systems comprising same for controlled or sustained release of bioactive molecules. In particular, the invention relates to polymeric beads having a two-phase core and shell structure and to polymeric delivery systems comprising same that provide sustained release of ... 09/22/05 - 20050208133 - Gastrointestinal-specific multiple drug release system The present invention provides compositions and methods for the multiple release of a drug in the gastrointestinal tract of a subject through the use of an oral multiple drug release system. The system provides site-specific release of the drug to both the small intestine and the colon in the form ... 09/15/05 - 20050202089 - Sustained-release pharmaceutical formulations containing mizolastine A sustained-release pharmaceutical formulation containing mizolastine, a core formed of a sustained-release table containing mizolastine combined with a fatty matrix and an organic acid, the tablet being coated. ... 09/08/05 - 20050196445 - Edible microcrystalline cellulose and carrageenan coating composition The present invention relates to novel, edible, hardenable, prompt release coatings for pharmaceutical, nutraceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods, etc., comprising microcrystalline cellulose and a film forming amount of carrageenan, wherein such coatings do not contain a plasticizer, a strengthening polymer ... 09/08/05 - 20050196444 - Aqueous polymer dispersions based on alkyl (meth)acrylates ii) 0.05 to 5% by weight of a monoolefinically unsaturated C3-C8 carboxylic acid iii) 0 to 35% by weight of further free-radical polymerizable monomers, where the total of i), ii), and iii) equals 100% by weight, in the presence of 0.001 to 1.0% by weight, based on the total weight ... 08/25/05 - 20050186278 - Gastroprotected formulations containing alph-amylase inhibitors Disclosed are gastroresistant formulations of phaseolamin characterized in that the enteric coating consists of shellac or other coatings compatible with nutritional use. ... 08/18/05 - 20050181053 - Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) ... 08/18/05 - 20050181052 - Lansoprazole microtablets A pharmaceutical composition comprising microtablets, wherein said microtablets comprise lansoprazole, a lubricant, optionally one or more excipients, and an enteric coating, wherein the weight ratio of lansoprazole to lubricant is from about 1:4 to about 8:1, wherein said microtablets have a tablet size of about 1 mm to about 4 ... 08/11/05 - 20050175699 - Multilamellar system for the administration of active agents by means of ingestion Multilamellar device for the administration of active substances by ingestion. It is disclosed a device with a support film (2)(15) on which a preparation said matrix layer (12 to 14) constituted, of active(s), liquid or solid ingredients giving jellified preparations, is coated. It is possible to superimpose several matrix layers ... 08/04/05 - 20050169996 - Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) ... 08/04/05 - 20050169995 - Modulation of gastrointestinal epithelium proliferation through the wnt signaling pathway These results indicate the efficacy of systemic expression of secreted Wnt antagonists as a general strategy for conditional inactivation of Wnt signaling in adult organisms, and illustrate a striking reliance on a single growth factor pathway for the maintenance of the architecture of the adult small intestine and colon. These ... 07/28/05 - 20050163847 - Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug Disclosed is a pharmaceutical dosage form including a therapeutically effective amount of an NSAID and an antiulcerative agent. ... 07/28/05 - 20050163846 - Preparation composition containing acid-unstable physiologically active compound, and process for producing same It is intended to disclose a preparation composition which enables convenient production of a sustained-release preparation composition which contains an acid-unstable physiologically active compound and which has the desired sustained-release property. In other words, the preparation composition according to the present invention comprises: a core containing an acid-unstable physiologically active ... 07/28/05 - 20050163845 - System for the controlled release of active ingredients A new release system is disclosed for releasing one or more active substances vehicularised in it, at a predetermined rate and duration. The system is constituted by a pharmaceutical tablet, coated with a film of polymeric material impermeable and insoluble in aqueous fluids; on the coating film, one or more ... 07/21/05 - 20050158385 - Coating technique for deposition of drug substance on a substrate The present invention relates to a multi-layered, physiologically tolerated oral dosage form for pharmaceutically active compounds. The dosage form comprises a central core, a middle layer, and an outer shell, at least one of which includes at least one pharmaceutically active substance. By varying the diameter of the core, a ... 07/14/05 - 20050152978 - Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds This invention comprises pharmaceutical compositions for administering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver polycyclic, aromatic, antioxidant or anti-inflammatory compounds to the gastrointestinal tract after oral administration. ... 07/07/05 - 20050147678 - Controlled release oral dosage form A once a day bupropion hydrochloride formulation is disclosed. ... 06/30/05 - 20050142199 - Pharmaceutical dosage forms comprising tablet core having a tensile strength below 38 n/sqcm and a coating to protect the soft core A pharmaceutical dosage form comprising: a) a tablet core comprising a pharmaceutically active ingredient and one or more pharmaceutically active ingredient and one or more pharmaceutically acceptable adjuvants, the tablet core having a tensile strength of less than 38 N/cm2 before coating and fusion and b) a coating extending over ... 06/23/05 - 20050136111 - Novel composition and use A pharmaceutical composition which composition comprises an insulin sensitiser and a pharmaceutically acceptable carrier therefor, wherein the composition is arranged to provide a modified release of the insulin sensitiser and the use of such composition in medicine. ... ### FreshPatents.com Support |