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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Tablets, Lozenges, Or Pills > Sustained Or Differential Release Type > Discrete Particles In Supporting Matrix Discrete Particles In Supporting MatrixDiscrete Particles In Supporting Matrix patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.05/03/07 - 20070098796 - Controlled release compositions comprising a combination of isosorbide dinitrate and hydralazine hydrochrloride The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate ... 03/29/07 - 20070071820 - Delayed release pharmaceutical formulations Delivery of a drug is controlled to impart a delay before release after administration by formulating the drug with a disruption agent to provide a core, and coating the core with a regulatory membrane comprising a water-soluble gel-forming polymer and a water-insoluble film-forming polymer. ... 03/22/07 - 20070065512 - Modified and immediate release formulations of memantine The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or ... 03/15/07 - 20070059368 - Modified release formulations of anti-irritability drugs Modified or extended release formulations containing mesalamine compounds and associated methods are disclosed and described. In some aspects, such formulations may be substantially bioequivalent to known FDA approved mesalamine formulations such as PENTASA®. ... 03/15/07 - 20070059367 - Drug delivery system and associated methods A modified release pharmaceutical composition is provided and includes: at least one pharmaceutical; at least one compressible material; and at least one tableting material; wherein the composition has a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters ... 03/01/07 - 20070048378 - Nanoparticulate anticonvulsant and immunosuppressive compositions Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer. ... 02/15/07 - 20070036856 - Diltiazem controlled release formulation and method of manufacture A controlled release diltiazem dosage formulation comprising a plurality of diltiazem pellets and a gel-forming material where the time of maximum diltiazem blood plasma levels occurs more than 8 hours after administration and preferably more than 10 hours after administration. ... 01/04/07 - 20070003621 - Dosage forms for movement disorder treatment The invention relates to the improvement in the treatment of certain neural disorders/diseases, such as Parkinson's disease and other motor disorders. One aspect of the invention relates to drug compositions and dosage forms comprising said drug composition. Another aspect of the invention relates to methods of manufacturing the drug compositions ... 01/04/07 - 20070003620 - Morphine sulfate microgranules, method for preparing same and compositions containing same The present invention relates to sustained-release morphine sulfate microgranules each comprising a neutral support grain coated with an active layer and with a sustained-release layer, wherein the sustained-release layer contains a copolymer of methacrylic acid, and a silica selected from hydrophobic fumed silica, as well as pharmaceutical compositions containing them. ... 01/04/07 - 20070003619 - Coated particles for sustained-release pharmaceutical administration Coated microparticles for sustained-release of an active pharmaceutical ingredient after parenteral administration, and methods of producing such coated microparticles, are provided. The coated microparticles comprise core particles of an active pharmaceutical ingredient and a first polymeric coating on the core particles. The first polymeric coating is permeable to the active ... 12/07/06 - 20060275367 - Extended release formulations The present invention relates to an extended release formulation containing a poorly water soluble active ingredient and to a method for preparing the formulation. The formulation contains a wax-based extended release material, which provides the extended release of the active ingredient. ... 11/23/06 - 20060263429 - Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof A compressible mixture prepared from a waxy filler, cellulose filler, or a mixture thereof and a disintegrant is disclosed for the preparation of compressed pharmaceutical compositions containing coated pellets. The resulting compressed compositions exhibit substantially the same dissolution profiles as the pellets in the absence of the compressible mixture. ... 11/16/06 - 20060257482 - Modified release, multiple unit drug delivery systems The invention relates to novel modified release multiple unit systems, and methods of preparing these systems, which can be easily compressed into tablets or filled into capsules or sachets without affecting the desired release characteristics of the pharmaceutical active ingredients incorporated within the systems. The multiple unit tablet includes multiple ... 11/02/06 - 20060246135 - Micronized tanaproget, compositions, and methods of preparing the same The present invention provides compositions, desirably pharmaceutical compositions, containing micronized tanaproget. The compositions can also contain microcrystalline cellulose, croscarmellose sodium, anhydrous lactose, magnesium stearate, micronized edetate calcium disodium hydrous, and micronized sodium thiosulfate pentahydrate. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention ... 11/02/06 - 20060246134 - Timed, pulsatile release systems A unit multiparticulate dosage form for delivering one or more basic, active pharmaceutical ingredients into the body in need of such medications to achieve target PK (pharmacokinetics) profiles is described. The dosage form comprises one or more multicoated drug particles (beads, pellets, mini-/micro-tablets) having a barrier coating and a lag-time ... 10/19/06 - 20060233880 - Controlled release dosage forms A zero-order release pharmaceutical dosage form for oral administration to a patient comprising a core tablet sheathed in an annular body of compressed powder or granular material is provided. A preferred embodiment of the zero-order release pharmaceutical dosage form is a solid pharmaceutical dosage form which reduces contact of the ... 10/19/06 - 20060233879 - Controlled released dosage forms A zero-order release pharmaceutical dosage form for oral administration to a patient comprising a core tablet sheathed in an annular body of compressed powder or granular material is provided. A preferred embodiment of the zero-order release pharmaceutical dosage form is a solid pharmaceutical dosage form which reduces contact of the ... 10/12/06 - 20060228414 - Method for the preparation of controlled release formulations The methods disclosed herein are of use for the production of controlled release compositions. In particular, the methods provide the contacting of an organic phase containing a bioactive agent and a polymer with an aqueous phase containing an organic ion to create controlled release compositions containing bioactive agents. The present ... 09/14/06 - 20060204575 - Amphetamine formulations Amphetamine formulations comprise a plurality of particles comprising two or more pharmaceutically active amphetamine salts, wherein the dosage form, when administered under fed conditions provides a reduced variability in bioavailability as compared to the dosage form administered under fasted conditions. ... 08/31/06 - 20060193914 - Crush resistant delayed-release dosage forms The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance ... 08/10/06 - 20060177508 - Fast disintegrating tablet The invention concerns an improved multiparticulate tablet disintegrating in the mouth in contact with saliva in less than 40 seconds. The invention is characterised in that it is based on particles of coated active principle, said particles having intrinsic compression properties and a mixture of carriers, the proportion of carrier ... 07/20/06 - 20060159756 - Method to obtain microparticles containing an h+,k+-atp-ase inhibitor A method for the preparation of homogeneous microparticles containing a H+,K+-ATPase inhibitor by a spray freezing technique characterized in that the medium to be atomized into droplets is having a high solid content and comprising besides the acid labile H+,K+-ATPase inhibitor also a polymer and a liquid in which the ... 07/20/06 - 20060159755 - Method for producing a controlled release preparation The invention concerns a method for producing a controlled-release pharmaceutical preparation with a particle-containing coating, the coating being derived from an aqueous dispersion of a film-forming water insoluble polymer and a water soluble pore-forming agent. By suspending, instead of dissolving the pore-forming agent, the resulting coating will contain particles of ... 07/13/06 - 20060153915 - Sustained-release preparations and method for producing the same The present invention relates to sustained-release preparations prepared by double granulation and methods for producing the same. The sustained-release preparation according to the present invention enables maintenance of effective blood concentration of drug for many hours via sustained release of the drug over 12 hours or more, and further its ... 07/06/06 - 20060147529 - Granulate comprising an oily substance, corresponding production method and tablet The invention relates to a process for the preparation of granules comprising an oily substance. It relates also to granules for a pharmaceutical formulation and to a tablet as a product of further processing. ... 06/22/06 - 20060134209 - Sustained-release nanoparticle compositions and methods for using the same The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition. ... 06/08/06 - 20060121114 - Method of manufacturing sustained release microbeads containing venlafaxine hcl A sustained release Venlafaxine composition that includes a plurality of non-agglomerated, uniformly-shaped and sized microbeads of inert core particles having a first coating layer. The first coating layer includes an active agent of Venlafaxine or a pharmaceutical acceptable salt thereof, a binder, and an anti-tack agent. The active agent is ... 05/11/06 - 20060099256 - Microspheres and related processes and pharmaceutical compositions The instant invention provides microspheres and related processes and pharmaceutical compositions useful in the controlled delivery of a wide variety of active ingredients. In one embodiment, the microspheres comprise an active ingredient dispersed within a polymeric composition comprising a first pH insensitive hydrophobic polymer and second pH sensitive hydrophobic polymer, ... 04/13/06 - 20060078614 - Taste-masked pharmaceutical compositions There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity in about 60 seconds forming a smooth, ... 04/06/06 - 20060073203 - Dry polymer and lipid composition The present invention provides an orally administrable composition comprising a dry mixture of polymer, lipid and bioactive agent, being capable on contact with water or GI tract liquid of forming particles comprising said lipid and said bioactive agent and optionally also water. It is preferable that such particles have a ... 03/30/06 - 20060068010 - Method for improving the bioavailability of orally delivered therapeutics The disclosed invention is a method and composition for improving the bioavailability of a pharmaceutically active ingredient comprising an oral dosage form consisting essentially of a granulation of active ingredient, amino acid, and hydrophilic polymer, wherein the granulation is dispersed in an immediate release or extended release excipient. ... 03/16/06 - 20060057199 - Orally disintegrating tablets of atomoxetine A coated multi-particulate pharmaceutical dosage form such as an orally disintegrating tablet (ODT) presentation for delivering atomoxetine or a pharmaceutically acceptable salt thereof, a selective norepinephrine reuptake inhibitor indicated for the treatment of ADHD, into the body to maintain a therapeutically effective amount of atomoxetine in the plasm. The dosage ... 03/16/06 - 20060057198 - Drug delivery from embolic agents A pharmaceutical composition for uterine fibroid embolisation comprises a polymer and, associated with the polymer in a releasable form, a COX inhibitor, e.g. a non-steroidal anti inflammatory drug, such as ibuprofen. The polymer is preferably in particulate form, such as in the form of microspheres. A suitable polymer is a ... 03/09/06 - 20060051419 - Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof An extended release pellet comprising an active ingredient selected from pramipexole and the pharmaceutically acceptable salts thereof, and at least one release-modifying excipient. ... 02/09/06 - 20060029670 - Pharmaceutical formulations and method for making The invention relates to a process of making an oral pharmaceutical formulation with variably adjustable release rate, which comprises one or more active ingredients, and one or more sucrose ester of a fatty acid as the sole release-controlling agent for said active ingredient wherein when the dosage form is a ... 12/29/05 - 20050287211 - Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition The present invention relates to an oral pharmaceutical composition in particle form, which comprises particles that contain a drug at the core of the pharmaceutical composition in particle form; a middle layer that contains two types of water-soluble components, an insolubilizer and an insolubilizing substance; and an outer layer for ... 12/15/05 - 20050276853 - Chronotherapeutic dosage forms and methods of treatment using chronotherapy A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core. ... 12/01/05 - 20050266077 - Resorbable matrices with coatings for delivery of bioactive compounds This invention relates to the production and use of coated inorganic-biopolymer complexes for the controlled release of bioactive compounds including medicinals. Advantageously, the delivery system compositions include an inorganic, a matrix polymer, and a coating. Advantageously, the inorganic used is calcium sulfate. ... 10/27/05 - 20050238716 - Colloidal drug carrier system The present invention relates to a drug carrier system comprising a plurality of colloidal particles having a core and a shell, said particles being comprised of copolymer molecules, which copolymer comprises at least one A block and at least one B block different from the at least one A block, ... 10/13/05 - 20050226928 - Novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described. ... 09/08/05 - 20050196443 - Pulsatile release compositions and methods for enhanced intestinal drug absorption Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and ... 08/18/05 - 20050181050 - Dosage forms using drug-loaded ion exchange resins A multiparticulate, modified release composition for oral administration has been developed. The formulation is made by complexing a drug with an ion-exchange resin in the form of small particles, typically less than 150 microns. The present invention provides novel extended release coated ion exchange particles comprising drug-resin complexes, produced by ... 08/18/05 - 20050181049 - Composition and method for enhancing bioavailability The present invention relates to compositions and methods for enhancing the bioavailability of beneficial agents with low water solubility. ... 08/18/05 - 20050181048 - Compositions and methods for timed release of a water-soluble nutritional supplement, methylsulfonylmethane The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain methylsulfonylmethane, C2-H6-O2-S and/or its dietary and nutraceutically acceptable salts of the same and/or hydrates of the active substance that provide a timed release formulation of the active substance. ... 08/18/05 - 20050181047 - Compositions and methods for timed release of water-soluble nutritional supplements The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain glucosamine sulfate, beta-(1,4)-2-amino-2-deoxy-D-glucose, and chondroitin, (C14H19NO14SNa2)n; N-acetylchondrosanine (2-acetamide-2-deoxi-D-galactopiranose) and D-gluoronic acid copolymer and/or their dietary and nutraceutically acceptable salts of the same and/or hydrates of the active substance that provide a timed ... 08/04/05 - 20050169994 - Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods The present invention also relates to carvedilol free base, salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and methods delivery of carvedilol forms to the lower gastrointestingal tract or methods to treat cardiovascular diseases, which may include, but are not limited to hypertension, congestive heart ... 07/14/05 - 20050152975 - Pharmaceutical composition The present invention relates to a granular pharmaceutical composition comprising a drug having a disagreeable taste, a wax and a sugar alcohol; a method for preparing the same; and a pharmaceutical product for oral administration, comprising the granular composition. The product excellently masks a disagreeable taste possessed by a drug ... 06/16/05 - 20050129759 - Sustained release compositions and controlled delivery method A sustained release composition comprising expanded thermoplastic microspheres, an active agent, and an optional release retardant is disclosed. The composition has an improved ability to stabilize and release the active agent over an extended time period. ... 06/02/05 - 20050118265 - Antifungal oral dosage forms and the methods for preparation The present invention relates to pharmaceutical dosage forms which include an antifungal having poor solubility. The pharmaceutical dosage forms of the present invention further comprise non-spherical granules, which do not contain a coated core region and may be formed into pharmaceutically acceptable dosage forms. The antifungal active pharmaceutical ingredients include ... 06/02/05 - 20050118264 - Extended release compositions comprising as active compound venlafaxine hydrochloride The present invention relates to an extended release composition comprising as active compound Venlafaxine Hydrochloride, in which Venlafaxine Hydrochloride is coated on a non pareil inert core, which coated core is then coated with polymeric layer which enables the controlled release of the Venlafaxine Hydrochloride. ... ### FreshPatents.com Support |