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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Implant Or Insert > Surgical Implant Or Material > Errodable, Resorbable, Or Dissolving Errodable, Resorbable, Or DissolvingErrodable, Resorbable, Or Dissolving patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/02/07 - 20070178138 - Biodegradable non-opthalmic implants and related methods Biodegradable non-ophthalmic implants include one or more agents dispersed within a biodegradable polymer component. The implants release the agents from the biodegradable polymer component to a target site of a patient as the implant degrades. The agents provided in the implants can be therapeutic agents or diagnostic agents and are ... 08/02/07 - 20070178137 - Local control of inflammation A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. ... 08/02/07 - 20070178136 - Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments Implantable or insertable medical devices are described, which include one or more polymeric regions and one or more therapeutic agents. The polymeric regions, which regulate the release of one or more therapeutic agent from the medical device, contain copolymer molecules, each of which includes one or more soft segments and ... 08/02/07 - 20070178135 - Medical articles containing biodegradable polymers and acid-neutralizing cationic species According to an aspect of the present invention, medical articles are provided, which are at least partially biodegradable. The medical articles comprise (a) biodegradable polymers that produce acidic molecules upon degradation; and (b) acid neutralizing cationic species. ... 07/19/07 - 20070166353 - Osteogenic proteins Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods ... 07/19/07 - 20070166352 - Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. ... 07/12/07 - 20070160648 - Methods for treating otic disorders Loss of hearing can be treated by implanting a sustained-release drug delivery device in the inner ear. The slow delivery of medication from the implanted device to the tissues of the ear, including the inner ear, can treat numerous conditions of the ear while avoiding the side effects associated with ... 07/05/07 - 20070154521 - Tri-branched biologically active copolymer The present invention discloses a tri-branched copolymer comprising a hydrophobic domain, a hydrophilic domain, a biologically active moiety, and an alkyl core of 2 to 10 carbon atoms. The hydrophobic domain, the hydrophilic domain, and the biologically active moiety are separately linked to the alkyl core of 2 to 10 ... 07/05/07 - 20070154520 - Pharmaceutical compositions having an ethylene carbonate content of 70 to 100 Mol %, an intrinsic viscosity of 0.4 to 4.0 dl/g measured in chloroform at 20° C. at a concentration of 1 g/dl and a glass transition temperature of from 5 to 50° C., degradable by surface erosion which is governed by ... 06/21/07 - 20070141113 - Unsymmetrical aromatic ether diacids and absorbable polymers therefrom Polymers formed from the functionalized unsymmetrical aromatic ether diacids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications. ... 06/21/07 - 20070141112 - Drug-eluting articles with improved drug release profiles The present invention relates to drug-eluting articles with multiple polymeric coatings arranged and constructed to provide improved drug release profiles. Specifically, the present invention relates to drug-eluting articles that each comprises a substrate, a first polymeric layer over said substrate, and a second polymeric layer over said first polymeric layer. ... 06/21/07 - 20070141111 - Porous medical device and method for its manufacture Porous bioabsorbable, bioactive and load-bearing composite medical device structure includes a plurality of regular textile planar layers (1a, 1b . . . ) formed of continuous bioabsorbable polymer matrix and bioceramic fibers acting as reinforcements, both included in continuous fibrous elements (3) forming the textile layers. The layers are placed ... 06/14/07 - 20070134296 - Polymeric stent having modified molecular structures in selected regions of the flexible connectors A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented ... 06/14/07 - 20070134295 - Polymeric stent having modified molecular structures A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented ... 06/14/07 - 20070134294 - Polymeric stent having modified molecular structures in selected regions of the flexible connectors A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented ... 06/07/07 - 20070128250 - Poly(ester urea) polymers and methods of use The invention provides high molecular weight, crystalline or semi crystalline biodegradable and biocompatible poly(ester urea) (PEU) polymers useful for making vascular stents and hard tissue replacement implants, such as bone substitutes. The PEU polymers are based on α amino acids and are made by a polycondensation reaction. PEU polymer compositions ... 05/31/07 - 20070122449 - Biodegradable implantable drug delivery device The invention relates to biodegradable and implantable devices for the in situ delivery of a pharmaceutical composition to a human or animal that comprise a generally discoid body, having at least one aperture through which the body is anchorable by suture, and that are formed from biodegradable polymeric compositions. The ... 05/31/07 - 20070122448 - Compositions and methods to create a vascularized environment for cellular transplantation The present invention generally relates to biocompatible devices suitable for increasing cellular HIF-1 α protein levels. In particular, the present invention relates to an implant comprising a biocompatible support loaded with at least one pharmaceutical agent capable of increasing cellular HIF-1 α protein levels to promote vascularization at or near ... 05/24/07 - 20070116739 - Resorbable thin membranes Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The membranes are formed to have very thin thicknesses, for example, thicknesses between ... 05/24/07 - 20070116738 - Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof consisting of: a core (i) comprising an active principle dispersed in a polymeric matrix of polylactic-glycolic acid (PLGA) copolymer, a coating in film form (ii), comprising as the main component a lactic-glycolic acid ... 05/24/07 - 20070116737 - Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers ... 05/10/07 - 20070104759 - Polymeric delivery formulations of leuprolide with improved efficacy The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The ... 05/03/07 - 20070098759 - Method for regenerating cartilage Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns. ... 04/19/07 - 20070087034 - Drug delivery system and method of manufacturing thereof In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, ... 04/19/07 - 20070087033 - Self-fixating scaffolds A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged. ... 04/12/07 - 20070082023 - Supple tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan Supple tissue dressing assemblies are formed from hydrophilic polymer sponge structures, such as chitosan. The supple tissue dressing assemblies are characterized by suppleness or multi-dimensional flexibility. The assemblies can be flexed, bent, folded, twisted, and even rolled upon itself before and during use, without creasing, cracking, fracturing, otherwise compromising the ... 04/05/07 - 20070077277 - Compositions and uses thereof Methods of controlling serum glucose levels in an individual are described, the methods including the step of administering to said individual a therapeutic food composition comprising a waxy and/or hydrothermally treated starch. The method may be used to treat or prevent hypoglycaemia in patients susceptible to hypoglycaemic episodes, for example ... 03/22/07 - 20070065484 - In situ occlusion using natural biodegradable polysaccharides In situ formed biodegradable occlusions including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. ... 03/22/07 - 20070065483 - In vivo formed matrices including natural biodegradable polysaccharides and uses thereof In vivo formed matrices including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The matrix can also include a bioactive agent which can be released to provide a therapeutic effect to a patient. ... 03/22/07 - 20070065482 - Articles including natural biodegradable polysaccharides and uses thereof Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient. ... 03/22/07 - 20070065481 - Coatings including natural biodegradable polysaccharides and uses thereof Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. ... 03/15/07 - 20070059338 - Compositions and techniques for localized therapy A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the ... 03/15/07 - 20070059337 - Cyclic acetal biomaterials A novel class of Cylic Acetal biomaterials (CABs) based on a cyclic acetal unit is disclosed and claimed by Applicants. Two novel biomaterials suitable for use in a variety of biological applications including in the orthopedic field for joint and cartilage replacement and/or repair, and bone cement. The biomaterials are ... 03/15/07 - 20070059336 - Anti-angiogenic sustained release intraocular implants and related methods Biocompatible intraocular drug delivery systems include a anti-angiogenic therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three ... 03/08/07 - 20070053954 - Macromer-melt formulations The invention provides methods and articles for the administration of a biologically active substance (BAS). These methods and articles provide for the controlled and sustained delivery of relatively large quantities of these substances with a low burst effect. The articles made using the method of the invention have increased percentages ... 02/22/07 - 20070042018 - Absorbable endo-urological devices and applications therefor This invention deals with an absorbable/disintegratable endo-urological stent and applicators for introduction into biological conduits, including such as urethras and ureters, with said stent comprising a fiber-reinforced, multicomponent tube made of polyesters having a range of physicochemical properties. ... 02/15/07 - 20070036835 - Hermetically sealed devices for controlled release or exposure of reservoir contents Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the ... 02/15/07 - 20070036834 - Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome p450 enzymes and membrane efflux systems following vaginal and oral cavity administration A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents ... 02/01/07 - 20070026045 - Reinforced matrices A reinforced matrix membrane containing one or more scaffold-forming proteins suitable for cell growth and for use in chondrocyte cell transplantation, and method of making same. The scaffold is incubated with the collagen matrix in solutions, colloidal dispersions, or suspensions of stabilizing proteins. The reinforced matrix may be used in ... 02/01/07 - 20070026044 - Use of vegf for treating bone defects The present invention provides pharmaceutical compositions comprising VEGF or variants thereof for promoting bone formation, in vitro and in vivo. Methods of using those compositions are also provided. Compositions and methods of the present invention can be used for promoting and improving the repair process in subjects with bone defects. ... 02/01/07 - 20070026043 - Medical devices combined with diblock copolymer compositions The present invention provides a medical device combined with a polymeric coating material comprising a bioerodable diblock copolymer and optionally a therapeutic agent. ... 02/01/07 - 20070026042 - System for treating aneurysmal disease Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed ... 02/01/07 - 20070026041 - Pea-tempo/pea-bz coatings for controlled delivery of drug from implantable medical devices Provided herein are coating comprising PEA-TEMPO/PEA-BZ for implantable medical devices, the coating being useful for the controlled delivery of bioactive agents into a patient's body. ... 01/25/07 - 20070020312 - Method of fabricating a bioactive agent-releasing implantable medical device The present invention relates to methods of controlling the loading of a bioactive agent into a polymeric carrier to be coated on an implantable medical device to achieve controlled release of the bioactive agent. ... 01/25/07 - 20070020311 - Medicament delivery device and a method of medicament delivery A medicament delivery device and method of delivery a medicament is provided wherein the device is insertable into the uterine myometrium for the delivery of medicaments to the pelvic area and organs thereof, for example, the bladder, peritoneum, the vulva, vagina, fallopian tubes, ovaries and uterus and then to the ... 01/18/07 - 20070014832 - Therapeutic compositions and methods Methods of promoting healing through enhanced regeneration of tissue (e.g. hard tissue or soft tissue) by contacting the tissue or the surrounding tissue with an anti-inflammatory agent. These methods are useful in a variety of dental and orthopedic applications. ... 01/18/07 - 20070014831 - Biodegradable occlusive device with moisture memory The present invention relates to a biodegradable occlusive device and methods for treating aneurysm of a patient comprising deploying a flexible biodegradable occlusive device with a moisture memory and a controlled biodegradation, and deploying a retaining stent for preventing the occlusive device from being inadvertently dislodged from the sac. ... 01/18/07 - 20070014830 - Drug-releasing sinus stent The present invention relates to a stent, adapted for deployment in a nasal sinus, comprising a matrix metalloproteinase-inhibiting substance and capable of locally releasing in a controlled manner a therapeutically effective amount of said matrix metalloproteinase-inhibiting substance. The invention further relates to a method for treatment of a diseased or ... 01/11/07 - 20070009573 - Method of forming immediate release dosage form Provided among other things is a method of making an elongate dosage form comprising: providing an elongate core with two ends and a waist, the core comprising a bioactive agent and a release agent that swells on contact with water; coating the core with a polymer coating; enrobing the ends ... 01/11/07 - 20070009572 - Micro-structured and nano-structured surfaces on biodegradable polymers In embodiments of the present invention, a biodegradable/biodegradable polymer film may be used as a scaffold for tissue engineering scaffolds for engineering organized organs, such as vascular grafts, for example. In one embodiment, an ultraviolet (UV) resin made from a diacrylated biodegradable oligomer is molded into a flexible scaffold having ... 01/04/07 - 20070003599 - Implantable or insertable medical devices for controlled delivery of a therapeutic agent The present invention is directed to novel implantable or insertable medical devices that provide controlled release of a therapeutic agent. According to an embodiment of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at ... 01/04/07 - 20070003598 - Osteogenic implants for soft tissue An osteogenic implant includes a degradation agent in solid form and an osteogenerative agent in solid form. The osteogenic implant is configured to release the degradation agent prior to releasing the osteogenerative agent. ... 01/04/07 - 20070003597 - Polymerized and modified rapamycins and their use in coating medical prostheses Compositions of matter comprise linked pluralities of mTOR-binding molecules, such as rapamycin. The compositions may be directly polymerized or may comprise rapamycin or other mTOR-binding molecules covalently or non-covalently attached to a backbone molecule. The compositions may be bound to vascular prostheses and other implantable devices in order to inhibit ... 01/04/07 - 20070003596 - Drug depot for parenteral, in particular intravascular, drug release A drug depot suitable for the parenteral, in particular intravascular, release of at least one drug which may be present as a base or corresponding protonised salt, wherein the base has a pKb value ranging from 2 to 6. The drug depot contains elementary magnesium in a biocorrodible form for ... 01/04/07 - 20070003595 - Three dimensional micro-environments and methods of making and using same The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties ... 01/04/07 - 20070003594 - Tissue engineering scaffold A tissue engineering scaffold for cell, tissue or organ growth comprises a biocompatible porous polyurethane cellular material comprising a plurality of substantially spherical voids of diameter from 20 to 300 microns, preferably 80 to 200 microns, interconnected by generally elliptically shaped pores. The cellular material has a void content of ... 01/04/07 - 20070003593 - Bone paste A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in ... 01/04/07 - 20070003592 - Biodegradable phase separated segmented multi block co-polymers The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. According to the invention a biodegradable, phase separated copolymer is provided, comprising segments of a soft prepolymer (A) having a ... 12/28/06 - 20060292201 - Methods for the in situ treatment of bone cancer The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning an implant containing and/or coated with at least one active agent for treating malignant cells directly in/on or ... 12/21/06 - 20060286146 - Hemostatic compositons and methods The present invention provides methods and compositions involving resorbable hemostatic agents that have the essential absence of microfibrillar collagen. Resorbable hemostatic agents of the present invention comprise polyethylene glycol, which controls bleeding in tissue and does not delay or interfere with healing. The resorbable hemostatic agents of the present invention ... 12/21/06 - 20060286145 - Deployment system for a medical device A delivery and deployment system for a self-expanding stent comprises a proximal handle having a rotatable thumbscrew and a sliding component which is attached to a distal stent restraining sheath. A rigid open coil spring is provided for converting rotation of the thumbscrew into translation of the sliding component). The ... 12/21/06 - 20060286144 - Reinforced collagen scaffold A fiber reinforced basic collagen scaffold with neutralization capacity for delivery of protein based bioactives that have higher solubilities under acidic condition than at neutral pH. ... 12/14/06 - 20060280775 - Biabsorbable implant having a varying characteristic A bioabsorbable implant or its part consists of a structure having a varying characteristic in at least in one direction defining a gradient corresponding this characteristic. The structure comprises bioabsorbable polymer and another substance within or next to said bioabsorbable polymer. The structure is constituted of a wound or folded ... 12/14/06 - 20060280774 - Compositions and methods for treating glaucoma Implants and methods are provided for modulating wound healing and controlling infection to improve the success of glaucoma filtration surgery. Formulations of one or more therapeutically active agents and a biodegradable polymer provide a substantially constant rate of release for an extended period of time. ... 12/14/06 - 20060280773 - Methods and devices for maintaining patency of surgically created channels in a body organ This is directed to methods and devices suited for maintaining an opening in a wall of a body organ for an extended period. More particularly devices and methods are directed maintaining patency of channels that alter gaseous flow within a lung to improve the expiration cycle of, for instance, an ... 12/14/06 - 20060280772 - Methods and devices for maintaining surgically created channels in a body organ This is directed to methods and devices suited for maintaining an opening in a wall of a body organ for an extended period. More particularly devices and methods are directed maintaining patency of channels that alter gaseous flow within a lung to improve the expiration cycle of, for instance, an ... 12/14/06 - 20060280771 - Drug delivery system The subject invention provides a drug delivery system comprising at least one compartment consisting of (i) a drug-loaded thermoplastic polymer core, (ii) a drug-loaded thermoplastic polymer intermediate layer and (iii) a non-medicated thermoplastic polymer skin covering the intermediate layer, wherein said intermediate layer is loaded with (a) crystals of a ... 12/07/06 - 20060275341 - Thin foam coating comprising discrete, closed-cell capsules This application relates to a thin foam coating comprising discrete, closed-cell capsules. The coating may be applied to an implantable medical device, such as a stent. The closed-cell capsules each having an outer polymeric shell and an inner liquid core containing the drug. The polymeric shells degrade in vivo to ... 12/07/06 - 20060275340 - Biocompatible controlled release coatings for medical devices and related methods Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with ... 12/07/06 - 20060275339 - Use of antiseptic active principles in pmma bone cements The invention concerns the use of polyhexamethylene biguanide in PMMA bone cements, which preferably do not contain antibiotics. The cements exhibit a concentration of active principle not exceeding 1 wt. % relative to the total weight of the cement, which is a concentration sufficiently high to prevent microbial colonization of ... 11/30/06 - 20060269587 - Antisense restenosis composition and method The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel ... 11/23/06 - 20060263408 - Implantable medical device seeded with mammalian cells and methods of treatment The present invention relates to an implantable medical device containing a porous scaffold which is seeded with at least one mammalian cell other than immune cells and which is disposed within the device, which device is suitable for the treatment of a mammalian disease, more specifically, diabetes mellitus. ... 11/16/06 - 20060257449 - Methods, compositions, systems, and devices for bone fusion The present invention is directed to methods, compositions, systems, and medical devices for fusing bone. ... 11/16/06 - 20060257448 - Resorbable polymer composition, implant and method of making implant Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making the implants are disclosed. Polymer compositions include a base material having a polymer matrix of resorbable polymer(s) or copolymer(s), and a glycerol mono-, di-, or triester derivative, wherein the glycerol ... 11/09/06 - 20060251702 - Implantable materials and methods for inhibiting tissue adhesion formation Described are materials and methods for inhibiting the formation of tissue adhesions. In one aspect, a prosthetic tissue support mesh, and especially such a mesh comprised of a remodelable material that promotes tissue ingrowth, incorporates an effective amount of an anti-inflammatory compound such as a non-steroidal anti-inflammatory drug (NSAID) to ... 11/09/06 - 20060251701 - Localized delivery of nucleic acid by polyelectrolyte assemblies The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods ... 11/02/06 - 20060246110 - Sustained release pharmaceutical composition A sustained release delivery apparatus including a silicone support material formed from a methyl-vinyl siloxane polymer including a fumed silica as a reinforcing filler; a pharmaceutically active composition carried in or on the silicone support material; the pharmaceutically active composition including at least one growth and/or reproduction-associated pharmaceutical component; analogue ... 11/02/06 - 20060246109 - Concentration gradient profiles for control of agent release rates from polymer matrices The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In ... 11/02/06 - 20060246108 - Amorphous poly(d,l-lactide) coating Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, ... 11/02/06 - 20060246107 - Use of one or more elements from the group containing yttrium, neodymium and zirconium and pharmaceutical compositions containing said elements A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a ... 10/26/06 - 20060240072 - Crosslinkable macromers A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or ... 10/26/06 - 20060240071 - Non-hormonal vaginal contraceptive An intravaginal contraceptive device has a biocompatible support structure constructed and configured to be inserted into a mammal's vagina without substantially blocking the cervix, coated by a multilayer coating having one or more biodegradable polymers. The multilayer coating can be constructed and formed of materials such that the multilayer coating ... 10/26/06 - 20060240070 - Delivery of highly lipophilic agents via medical devices An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, ... 10/19/06 - 20060233857 - Degradable elastomeric network One aspect of the invention provides a degradable/biocompatible elastomer. The elastomer comprises a degradable cross-linked network of a hydrophobic, hydrolysable amorphous star polymer and a hydrophilic, biocompatible polymer. The network may be crosslinked thermally or by irradiation. In a preferred embodiment, the elastomer is used for a drug delivery system, ... 10/05/06 - 20060222681 - Controlled degradation materials for therapeutic agent delivery According to an aspect of the present invention, polymeric release regions are provided, which contain one or more partially biodegradable progenitor polymers and which control the release of one or more therapeutic agents disposed beneath or within the same. The progenitor polymers within the release regions are composed of a ... 10/05/06 - 20060222680 - Method of preparing crosslinked collagen microspheres The present invention is drawn to methods of preparing crosslinked collagen microspheres and microparticles, where a solution of soluble collagen in an aqueous acidic medium is combined with an emulsifying agent to form a first mixture of the soluble collagen solution and the emulsifying agent, the first mixture then is ... 09/28/06 - 20060216327 - Multilayer coating for releasing biologically-active agents and method of making A composition for use with healthcare products such as medical device includes one or more biologically-active agents for release into bodily fluids. The composition can be applied to a substrate to form an erodible layer and a polymer layer. Biologically-active agent(s) are releasable from the erodible layer and the polymer ... 09/28/06 - 20060216326 - Implantable devices formed of non-fouling methacrylate or acrylate polymers Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total ... 09/14/06 - 20060204547 - Drug delivery stent with extended in vivo release of anti-inflammatory A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as Pimecrolimus, from the stent to vascular tissue in need of treatment in a controlled and extended drug release profile for a period of ... 09/14/06 - 20060204546 - Methods and systems for delivering immunosuppressant and anti-inflammatory agents from a stent A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an immunosuppressant or anti-inflammatory agent from reservoirs in a stent to vascular tissue in need of treatment in a controlled, two phase drug release profile. It is envisioned ... 09/07/06 - 20060198870 - Medical devices containing rapamycin analogs This drug can be used in combination with a drug selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, cytostatic drugs, or combinations of these drugs. ... 09/07/06 - 20060198869 - Bioabsorable medical devices A medical device that is at least partially formed of a bioabsorbable metal alloy that includes a majority weight percent of magnesium and at least one metal selected of calcium, rare earth metal, yttrium, zinc, and/or zirconium. ... 09/07/06 - 20060198868 - Biodegradable coating compositions comprising blends The invention provides devices for treatment of a patient, wherein at least a portion of the device is provided with a biodegradable coating composed of a blend of bioactive agent and at least two biodegradable polymers or copolymers. The invention further provides methods of treatment utilizing the devices. ... 09/07/06 - 20060198867 - Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, ... 08/31/06 - 20060193893 - Medical devices The invention relates to medical devices, compositions and methods useful for administrating or delivering a cephalotaxine to a host. The cephalotaxines are useful in treating or preventing an angiogenic condition or disease. The invention provides for medical devices including coatings containing a matrix and a cephtalotaxine to treat an angiogenic ... 08/31/06 - 20060193892 - Polymer biodegradable medical device A medical device that is at least partially formed of a biodegradable polymer. The medical device can be at least partially formed by MEMS technology. The medical device can include one or more micro-structures that are also formed by MEMS technology. The medical device can include one or more biological ... 08/31/06 - 20060193891 - Medical devices and therapeutic delivery devices composed of bioabsorbable polymers produced at room temperature, method of making the devices, and a system for making the devices A method is provided of making a bioabsorbable appliance that includes selecting a first bioabsorbable polymer having a first glass transition temperature above about room temperature and selecting a second bioabsorbable polymer having a second glass transition temperature below about room temperature. The method also includes combining the first and ... 08/24/06 - 20060188547 - Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z′CH2COO— where z′ is an integer between ... 08/24/06 - 20060188546 - Medical devices employing novel polymers Medical devices with at least one surface comprising a polymer or polymers on the surface are provided. The polymer or polymers are capable of breaking down (e.g., including, but not limited to, hydrolyzing) in the physiologic milieu to form an active agent or agents under physiologic conditions, and can contain ... 08/24/06 - 20060188545 - Bioabsorbable composition and coatings including same Bioabsorbable compositions of A) blends of bioabsorbable homopolymers and/or copolymers containing glycolide and lactide and B) salts of fatty acids and/or fatty acid esters are described. Processes for making the compositions and surgical articles made totally or in part therefrom, including suture coatings, are also described. ... 08/17/06 - 20060182782 - Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same A polymer coating for medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. ... 08/17/06 - 20060182781 - Methods for treating ocular conditions with cyclic lipid contraining microparticles Biocompatible microparticles include a ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can ... 08/17/06 - 20060182780 - Resorbable hollow devices for implantation and delivery of therapeutic agents A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. ... 08/10/06 - 20060177482 - Stent with coatings containing self-assembled monolayers A medical device with a coating, particularly a drug eluting stent, is described. The coating includes a self-assembled monolayer. ... 08/10/06 - 20060177481 - Methods for forming regional tissue adherent barriers and drug delivery systems Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical ... 08/10/06 - 20060177480 - Drug-eluting biodegradable stent The present invention relates to a biodegradable stent comprising a luminal surface portion with a second degree of crosslink, an outer surface portion with a first degree of crosslink, and a wall between the luminal and outer surface portions, wherein the wall comprises a crosslinked material characterized by the first ... 08/10/06 - 20060177479 - Methods and devices for promoting epithelial cell differentiation and keratinization In one aspect, the present invention provides a biomaterial having at least one biocompatible surface. The biocompatible surface comprises a plurality of immobilized Notch ligand molecules, wherein the plurality of immobilized Notch ligand molecules are capable of promoting differentiation in one or more epithelial cells. In another aspect, the present ... 08/03/06 - 20060171990 - Drug delivery materials made by sol/gel technology The present invention relates to a method of producing a drug delivery material by encapsulating a biologically or therapeutically active agent in a shell, combining the encapsulated agent with a sol, and converting the combination into a solid or semi-solid drug delivery material. The present invention further relates to drug ... 08/03/06 - 20060171989 - Control of drug release by transient modification of local microenvironments Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the ... 08/03/06 - 20060171988 - Method of treatment using foams as artificial lymph nodes The present invention relates to pharmaceutical compositions for the improved activation of cells of the immune system that comprise a biocompatible implantable and an active pharmaceutical ingredient to be integrated into said foam, wherein said composition specifically activates cells of the immune system. In one preferred embodiment, said active pharmaceutical ... 08/03/06 - 20060171987 - Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix Using ethanol as plasticizer for preparing subcutaneous implants containing a dispersed active principle in a PLGA-based matrix by means of extrusion, the extrusion temperature, generally higher than 75° C., can be reduced to temperatures higher than the Tg of the PLGA, but lower than the boiling point of ethanol and ... 07/20/06 - 20060159721 - Drug-containing implants and methods of use thereof The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia ... 07/13/06 - 20060153896 - Methods and devices for improving biofixation of implantable vascular devices Methods and devices for improving biofixation of implantable vascular devices are provided. The methods and devices improve biofixation of implantable vascular devices by providing one or more thrombus-eliminating agents at a treatment site before and/or during and/or after vascular device implantation. ... 07/13/06 - 20060153895 - Drug-containing implants and methods of use thereof The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia ... 07/13/06 - 20060153894 - Multi-compartment delivery system This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the ... 07/13/06 - 20060153893 - Therapeutic composition for bone infectious disease A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment ... 07/06/06 - 20060147492 - Medical implants and anti-scarring agents Implants are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. The agent may be any suitable anti-scarring agent, e.g., a cell cycle inhibitor, and may be used in conjunction with a second pharmaceutical agent, ... 07/06/06 - 20060147491 - Biodegradable coating compositions including multiple layers The invention provides devices for treatment of a patient, wherein at least a portion of the device is provided with a biodegradable coating composed of multiple coated layers of biodegradable material. The invention further provides methods of treatment utilizing the devices. ... 07/06/06 - 20060147490 - New polymers and applications The present invention provides a biodegradable, biocompatible polymer that is capable of forming particles (micelles), vesicles, surfaces and membranes, and other structures in which a biologically active agent, e.g. a drug, can be incorporated in such a way that its release to the host can be controlled to a high ... 06/29/06 - 20060141006 - Methods and apparatus for treatment of aneurysmal tissue The present invention encompasses methods and apparatus for aiding aneurysm repair. ... 06/29/06 - 20060141005 - Compositions and medical devices utilizing bioabsorbable polymeric waxes The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about ... 06/29/06 - 20060141004 - Compositions and medical devices utilizing bioabsorbable polymeric waxes The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about ... 06/15/06 - 20060127445 - Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions. ... 06/08/06 - 20060121089 - Coatings for implantable medical devices The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof. ... 06/08/06 - 20060121088 - Compositions and methods for treating or preventing diseases of body passageways The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-proliferative agents, anti-inflammatory agents, and antibiotics. ... 06/08/06 - 20060121087 - Polymeric endoprostheses with modified erosion rates and methods of manufacture An erodible prosthesis comprising alternate rates of erosion is disclosed, wherein said alternate rates of erosion can be selectively initiated. Some embodiments according to the invention may comprise an agent for initiating an alternative rate of erosion, such as, for example, a sensitizer, dissolution inhibitor, photo-acid generator, biochemically active additive, ... 06/08/06 - 20060121086 - Drug-eluting stents coated with non-nucleotide p2y12 receptor antagonist compound The present invention provides a drug-eluting stent, wherein the stent is coated with one or more non-mucleotide P2Y12 receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed or damaged arterial vessel, a therapeutically effective amount of the P2Y12 receptor ... 06/08/06 - 20060121085 - Formulations for cell-schedule dependent anticancer agents The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, ... 06/08/06 - 20060121084 - Continuous phase composite for musculoskeletal repair A composite material for positioning in the anatomy to form a selected function therein. The composite may be resorbable over a selected period of time. The composite may allow for selected bone ingrowth as absorption of the composite occurs. ... 06/08/06 - 20060121083 - Anti-microbial medical implants and uses thereof A medical device or implant is disclosed. The medical device or implant comprises a body having at least one surface coated with, or including a peptide having at least 9 amino acid residues and less than 51 amino acid residues, the peptide including an amino acid sequence derived from an ... 06/01/06 - 20060115515 - Biodegradable implant and method for manufacturing one A biodegradable implant and a method for manufacturing one. The implant comprises a matrix component containing at least one biodegradable polymer or copolymer and a pyrrolidone plasticizer that is adapted to reduce the rigidity of the implant. The plasticizer substantially exits from the implant after coming into contact with tissue ... 05/18/06 - 20060105019 - Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque. ... 05/18/06 - 20060105018 - Therapeutic driving layer for a medical device The present invention regards the delivery of therapeutic at a target site. Systems that employ the present invention may employ a medical device sized to be inserted into a target site, a driving layer covering at least a portion of an accessible surface of the medical device, and a therapeutic ... 05/04/06 - 20060093648 - Hydrogels for orthopedic repair Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may ... 05/04/06 - 20060093647 - Multiple layer coating composition A multiple layer coating for application upon surfaces of an implantable medical device, a first layer of such coating includes an anti-thrombogenic factor and a second layer of such coating includes a hyperplasia inhibiting factor that is releasably contained therein. The hyperplasia inhibiting factor is controllably released from the multiple ... 04/27/06 - 20060088572 - Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function Medical devices with polymer coatings designed to control the release of angiotensin-(1-7) receptor agonists from medical devices are disclosed. The present application also discloses providing vascular stents with angiotensin-(1-7) receptor agonist-containing controlled-release coatings. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients ... 04/27/06 - 20060088571 - Biocompatible and hemocompatible polymer compositions Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings. Additional embodiments of the present invention ... 04/20/06 - 20060083772 - Coating compositions for bioactive agents A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a ... 04/20/06 - 20060083771 - Block-shaped scaffold for tissue engineering and production method thereof A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it ... 04/20/06 - 20060083770 - Medical devices and methods of preparation and use An implantable device having a coating with an eluting membrane and a permeable membrane disposed on a surface of the device is provided. The eluting membrane is typically a polymeric material capable of being infused with a biologically active, therapeutic substance. The permeable membrane is typically a polymeric material having ... 04/20/06 - 20060083769 - Method and apparatus for preparing bone Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a ... 04/13/06 - 20060078591 - Systems and methods for augmenting tissue volume A method of treating volume deficiency in cosmetic surgery and in urological stress incontinence is based upon the transplantation of one or more biologic collagen based tissues into the subcutaneous, deep dermal, or peri urethral space. In the preferred embodiment, mechanically morsellized dehydrated embryonic bovine matrix tissue is used, which ... 04/13/06 - 20060078590 - Resorbable ceramic compositions Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including ... 04/13/06 - 20060078589 - Device for treating oral wound gaps A device for treating oral wounds that form a gap and hence too large to suture. The device is intended to fill the resulting wound gap and upon contact with bleeding tissues cause local hemostasis. The device will remain in and protect the wound gap during the healing process. The ... 04/06/06 - 20060073183 - Therapeutic composition and a method of coating implantable medical devices A therapeutic composition is provided including a polysaccharide or a cationic peptide dissolved in an organic substance. The polysaccharide can be heparin or a derivative of heparin. The cationic peptide can be L-arginine, oligo-L-arginine or poly-L-arginine. The organic substance can be formamide. A method of coating an implantable medical device ... 04/06/06 - 20060073182 - Conveniently implantable sustained release drug compositions This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states. ... 03/30/06 - 20060067977 - Pre-dried drug delivery coating for use with a stent A method and apparatus for the provision of a coating for application to a medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component and solvent can also be provided. The ... 03/30/06 - 20060067976 - Formation of barrier layer A barrier layer and corresponding method of making provide anti-inflammatory and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The barrier layer is generally formed ... 03/30/06 - 20060067975 - Uv cured gel and method of making A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, ... 03/30/06 - 20060067974 - Drug delivery coating for use with a stent A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical ... 03/30/06 - 20060067973 - Bone void filler Novel biodegradable bone void filler compositions. The bone void filler compositions have a biodegradable material component, a porous osteoconductive component, and a therapeutic agent. The bone void filler optionally contains an osteoinductive component. Also disclosed is a method of using the bone void filler compositions to fill a bone void. ... 03/30/06 - 20060067972 - Devices for renal-based heart failure treatment Methods and devices are provided to preferentially deliver biologically active substances to a patient's renal artery, particularly for the treatment of congestive heart failure. The apparatus will comprise an implantable depot which may be in the form of a biodegradable vascular implant, a replenishable reservoir, a drug pump, or combinations ... 03/30/06 - 20060067971 - Bone void filler Novel biodegradable bone void filler compositions. The bone void filler compositions have a biodegradable material component, an osteoconductive component, and a therapeutic agent. The bone void filler optionally contains an osteoinductive component. Also disclosed is a method of using the bone void filler compositions to fill a bone void. ... 03/16/06 - 20060057184 - Process to treat avascular necrosis (avn) with osteoinductive materials A method of treating avascular necrosis (“AVN”) comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of ... 03/16/06 - 20060057183 - Indwelling stent As a therapy for angiostenosis, angioplasty (PTA, PTCA), in which a small balloon is inflated in a blood vessel to expand the vessel, has been widely practiced as a minimally invasive treatment. In this therapy, however, repeated stenosis (restenosis) occurs at a high incidence. In order to reduce the restenosis ... 03/02/06 - 20060045904 - Joint therapy A method for synergistically treating a joint of an animal, including introducing a cushioning agent into a joint; and introducing an enzyme or hormone adapted to stimulate cartilage production into the joint. The joint may be subjected to a compression regimen following injection of the cushioning agent and enzyme/hormone. Alternatively, ... 03/02/06 - 20060045903 - Musculo-skeletal implant having a bioactive gradient This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient. ... 03/02/06 - 20060045902 - Polymeric wrap for in vivo delivery of osteoinductive formulations The application discloses a polymeric wrap having one or more osteoinductive formulations, wherein each osteoinductive formulation comprises one or more osteoinductive agent(s). In one embodiment, the osteoinductive formulation(s) is contained within a biodegradable polymer sheet. In another embodiment of the invention, the polymeric wrap comprises at least two or more ... 03/02/06 - 20060045901 - Stents with drug eluting coatings The present invention relates generally to medical devices, preferably a stent, having a drug eluting surface coated or covered with a coating of particles comprising at least an outer layer, an inner layer, and a core comprising a therapeutic agent. Specifically, the invention relates to medical devices having a hydrophilic ... 02/16/06 - 20060034889 - Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof A water soluble, biodegradable AB type diblock copolymer which comprises 61 to 85% by weight of a biodegradable, hydrophobic A block comprising a biodegradable polyester, and 15 to 39% by weight of a biocompatible, hydrophilic B block comprising a monofunctional polyethylene glycol(PEG) having a number average molecular weight less than ... 02/16/06 - 20060034888 - Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety. ... 02/16/06 - 20060034887 - Implantable structure for prolonged and controlled release of an active principle The invention relates to an implantable structure of flexible consistency for the sustained and controlled release of an active substance, consisting of a bioresorbable support and an active substance, in which the bioresorbable support is formed of a material comprising an aliphatic polyester of therapeutic value as the main component. ... 01/26/06 - 20060018948 - Biodegradable implantable medical devices, methods and systems The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices. ... 01/26/06 - 20060018947 - Bioresorbable nerve guide rail A biologically resorbable nerve guide rail with a microporous guide tube of polymers of hydroxycarboxylic acids, where the porosity allows a metabolism through the tube wall, but prevents the passage of cells, and optionally several monofilaments of polymers of hydroxycarboxylic acids located in the guide tube, is characterized in that ... 01/19/06 - 20060013857 - Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects Component 2, a dispersing vehicle, may be esters unsubstituted and N-substituted pyrrolidones of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as ... 01/19/06 - 20060013856 - New and advantageous hydrogel composition New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine. ... 01/12/06 - 20060008505 - Product A delivery system for a haemostatic material comprises a self adhesive strip of a bioadhesive, especially pectin and a glycerol plasticiser. The haemostatic material may be a microdispersed oxidised cellulose which is dispersed in the strip. The strip is applied to control localised bleeding from surface skin wounds such as ... 01/12/06 - 20060008504 - Flexible bone composite The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric layer including a synthetic polymer. The calcium-containing layer can include ... 01/05/06 - 20060002980 - High density fibrous polymers suitable for implant This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, ... 01/05/06 - 20060002979 - Multifunctional biodegradable composite and surgical implant comprising said composite A multifunctional biodegradable composite has: a) bioabsorbable polymer matrix phase (M) b) bioabsorbable reinforcing element (R), and c) bioactive tissue/cell reaction modifying agent (TRMA) dispersed in said bioabsorbable matrix phase and selected from the group consisting of anti-inflammatory drugs and statins. Said biodegradable composite may be in a surgical implant ... 01/05/06 - 20060002978 - Biodegradable scaffolds and uses thereof The invention is directed to scaffolds containing porous polymer material prepared by a process of gas foaming/particulate leaching and a wet granulation step prior to gas foaming and particulate leaching, particularly having a characteristic interconnected pore structure, as well as sustained release of protein, DNA or cells, and to methods ... 01/05/06 - 20060002977 - Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque ... 01/05/06 - 20060002976 - Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, linoleic, caprylic, capric, ... 12/22/05 - 20050281860 - Surgically implanted devices having reduced scar tissue formation An anti-proliferative drug, such as rapamycin or taxol, is placed onto or within a sheet of material or mesh. The strands onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. Surgical sutures or staples may also be coated and used ... 12/15/05 - 20050276837 - Controlled release bioactive agent delivery device The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of ... 12/08/05 - 20050271703 - Controlled release bioactive agent delivery device The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of ... 12/08/05 - 20050271702 - Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. ... 12/08/05 - 20050271701 - Progenitor endothelial cell capturing with a drug eluting implantable medical device A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding ... 12/08/05 - 20050271700 - Poly(ester amide) coating composition for implantable devices A poly(ester amide) (PEA) coating with enhanced mechanical and/or release rate for coating an implantable device, such as a drug-eluting stent, is disclosed. A method of forming the PEA coating onto a device and a method of treating a disorder, such as restenosis, are also disclosed. ... 12/08/05 - 20050271699 - Biodegradable composition with prolonged release of the biological active compound and preparation thereof Biodegradable antitumor composition with prolonged release has at least one antitumor agent and a biodegradable oligoester carrier, having a numeric mean relative molecular mass Mn of from 650 to 7,500, a mass mean relative molecular mass Mw from 800 to 10,000 and a glass transition temperature Tg from −35 to ... 11/17/05 - 20050255142 - Coatings for medical articles including natural biodegradable polysaccharides Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. ... 11/03/05 - 20050244460 - Biodegradable crosslinking strategies using triglycidyl amine (tga) The invention relates to implantable biodegradable bioprostheses and methods for making and using the bioprostheses. The implantable biodegradable bioprosthesis includes biomolecules having a reactive moiety and optionally a reactive group; and a biodegradable cross-linking moiety having (a) at least two linking moieties, wherein the at least two linking moieties are ... 11/03/05 - 20050244459 - Coating compositions for bioactive agents A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a ... 11/03/05 - 20050244458 - Sustained release intraocular implants and methods for treating ocular neuropathies Biocompatible intraocular implants include a beta adrenergic receptor antagonist and a polymer associated with the beta adrenergic receptor antagonist to facilitate release of the beta adrenergic receptor antagonist into an eye for an extended period of time. The beta adrenergic receptor antagonist may be associated with a biodegradable polymer matrix, ... 10/27/05 - 20050238691 - Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than ... 10/27/05 - 20050238690 - Controlling resorption of bioresorbable medical implant material The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve ... 10/27/05 - 20050238689 - Bioactive stents for type ii diabetics and methods for use thereof The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium ... 10/20/05 - 20050232971 - Biodegradable polymers for use with implantable medical devices The present invention relates to a stent fabricated of or coated with a composition comprising a biodegradable hydrophobic polymer containing water-labile bonds such that a device fabricated of the composition or the surface of a device coated with the requisite mechanical characteristics required of a stent and the polymer erodes ... 10/20/05 - 20050232970 - Process and systems for biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups. ... 10/13/05 - 20050226904 - Fibrous composite for tissue engineering Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation ... 09/29/05 - 20050214344 - Tissue engineered biomimetic hair follicle graft The present invention relates to an improved scaffold which is constructed to mimic the architecture of the native hair follicle. The present invention also relates to the use of specific compositions and methods of manufacture to produce scaffolds that combine biocompatibility with the desired rates of bioabsorption. In another embodiment, ... 09/29/05 - 20050214343 - Medical devices comprising a protein-tyrosine kinase inhibitor to inhibit restonosis Implantable medical devices having an anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of proteintyrosine kinase inhibitors are disclosed. The anti-restenotic protein-tyrosine kinase inhibitor is 4+4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2pyrimidinyl]amino]-phenyl]benzamide methanesulfonate and pharmaceutically acceptable derivatives thereof (imatinib mesylate). The anti-restenotic medial devices include stents, catheters, micro-particles, probes and vascular grafts. The medical ... 09/22/05 - 20050208101 - Coating composition for an implantable medical device and method for coating such a device The invention relates to a coating composition for an implantable medical device. The coating composition, which in this connection comprises at least one polymer and at least one bioactive agent, includes as bioactive substance naphthoquinone and/or a naphthoquinone derivative, in particular shikonin. ... 09/22/05 - 20050208100 - Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release The medical articles which comprise the following: (a) a ceramic or metallic region whose surface comprises a plurality of depressions, (b) a multilayer coating region comprising multiple polyelectrolyte layers deposited over the surface of the ceramic or metallic region; and (c) a therapeutic agent disposed beneath or within the multilayer ... 09/15/05 - 20050202061 - Optimized dosing for drug coated stents The inventors have found that both the drug dose and drug release profiles are significant factors for the safety and efficacy of drug coated stents. The inventors have identified optimum dosing and release kinetics for drug coated stents. In particular, the inventors have determined dosing and release kinetics that permit ... 09/15/05 - 20050202060 - Hydrogel forming system comprising peg derivative precursor Variation in precursor ratio and mass of double bond functionalized polyhydric alcohol precursor and polyethylene glycol diacrylate precursor provide a wide range of release rates of drug or other biologically active agent from hydrogel formed therefrom. ... 09/08/05 - 20050196426 - Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive ... 09/08/05 - 20050196425 - Positive modulator of bone morphogenic protein-2 Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone ... 09/01/05 - 20050191334 - Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time. ... 08/25/05 - 20050186251 - Method of promoting osteogenesis Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making said implants are disclosed. Polymer compositions comprise a base material including a polymer matrix of resorbable polymer(s) or copolymer(s), and N-methyl-2-pyrrolidone (NMP), wherein NMP is present in an amount imparting ... 08/18/05 - 20050181016 - Decullularized extracellular matrix of conditioned body tissues and uses thereof The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix ... 08/18/05 - 20050181015 - Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles Medical articles (for instance, a drug delivery patch or an implantable or insertable medical device) are provided that comprise a release region, which in turn comprises (a) polymeric carrier comprising a polymer (for instance, a hydrophobic polymer) and (b) drug loaded nanoparticles, which are dispersed within the polymeric carrier. The ... 08/18/05 - 20050181014 - Polymer-filler composites for controlled delivery of therapetic agents from medical articles A medical article comprising: (a) a therapeutic agent; and (b) a release region comprising (i) a polymer and (ii) a filler comprising inorganic platelet particles. Upon placement of such a medical article at a position on or within a patient, the release region regulates the rate of release of the ... 08/11/05 - 20050175670 - Medical treatment system and production method therefor The present invention has a purpose to provide a non-invasive drug delivery system made of biodegradable material slowly releasing a medicament for a prolonged period in a stable manner while embedded within a portion of a body where a flow of blood and/or lymph is rapid, and a manufacturing process ... 08/04/05 - 20050169969 - Controlled delivery of therapeutic agents by insertable medical devices A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to ... 08/04/05 - 20050169968 - Conjugates comprising a biodegradable polymer and uses therefor Biologically active agents covalently linked to a polymer. The polymer is preferably a biodegradable polymer are provided. The biologically active agent is preferably a protein, such as an extracellular soluble protein, e.g., an extracellular enzyme. The enzyme can be an apyrase, e.g., NTPDase. Conjugates of the invention can be used ... 08/04/05 - 20050169967 - Surgical material comprising water glass fibres There is provided a surgical material formed using water soluble glass fibres, optionally together with a binding material such as polycaprolactone. One or more layers of non-woven glass fibre material may be present. The material, which is usually in sheet form, can be folded around a defective area of tissue ... 07/28/05 - 20050163822 - Biodegradable bio-absorbable material for clinical practice and method for producing the same Bio-absorbable polymers such as vascular stent and suture thread for use as materials for clinical practice have almost definite dynamic properties such as tensile strength and degradation rate for absorption. When the dynamic properties thereof are elevated, therefore, the bio-absorbable polymers turn fragile, involving slower degradation rate. When the degradation ... 07/28/05 - 20050163821 - Drug-eluting biodegradable stent and delivery means A biodegradable stent comprising a luminal surface portion with a second degree of crosslink, an outer surface portion with a first degree of crosslink, and a body between the luminal and outer surface portions, wherein the body comprises a crosslinked material characterized by the first degree of crosslink not less ... 07/28/05 - 20050163820 - Delivery system for bone growth promoting material A delivery system that includes a bone growth promoting material encapsulated within a water absorptive gelatinizable covering is used to promote bone growth in order to repair a bone defect and/or strengthen a weakened bone region. The delivery system may be shaped and sized in order to fit within a ... 07/21/05 - 20050158364 - Methods of making expandable foam-like biomaterials Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross ... 07/21/05 - 20050158363 - Multifaceted endovascular stent coating for preventing restenosis This invention deals with a carboxyl-bearing, amphiphilic, solid copolyester stent coating composition for multifaceted prevention of vascular restenosis through a plurality of physicopharmacological modes. The composition includes one or more bioactive compounds and a copolymerization product of polyalkylene glycol, end-grafted with one or more cyclic monomer and treated further to ... 07/21/05 - 20050158362 - Polymeric, fiber matrix delivery systems for bioactive compounds Multifunctional systems for delivery of bioactive compounds incorporated within or between polymeric fibers in a matrix are provided. Also provided are methods of delivering bioactive compounds via implementation, coating and/or wrapping of these systems and methods for modulating the rate of release of bioactive compounds from these delivery systems. ... 07/07/05 - 20050147647 - Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent. ... 07/07/05 - 20050147646 - Porous gelatin material, gelatin structures, methods for preparation of the same and uses thereof The present invention relates to a porous gelatin material in the form of spherical particles with a continuous pore structure and cast, three-dimensional, porous gelatin structures. The invention also comprises methods for preparation of the porous gelatin materials and structures. The method for preparing the porous gelatin material in the ... 06/30/05 - 20050142165 - Implant device with a retinoid for improved biocompatibility An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device. may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a ... 06/30/05 - 20050142164 - Osteogenic device and a method for preparing the device The present invention is related to an osteogenic device and its preparation. Said device comprises a bone morphogenetic protein (BMP), preferably a modified BMP complex obtainable by a modification of the conventional guanidum hydrochloride extraction method and collagens, preferably collagen I or collagen IV, impregnated in and/or adsorbed on a ... 06/23/05 - 20050136093 - Implant for transport and release for pharmacologically active agents as well as a process for producing the same The present invention relates to an implant comprising (a) a polymer of the general formula (I) as a matrix material of the implant, wherein n is from 2 to ∞, and R1 to R6 are the same or different and represent a halogenalkoxy, alkoxy, alkylsulfonyl, dialkylamino or aryloxy group or ... 06/16/05 - 20050129737 - Devices and methods for pain management The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a ... 06/16/05 - 20050129736 - Compositions and methods for treating or preventing diseases of body passageways The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-proliferative agents, anti-inflammatory agents, and antibiotics. ... 06/09/05 - 20050123583 - Medical use of reuterin Use of reuterin, a naturally occurring β-hydroxypropinoaldehyde, in the manufacture of a biocompatible implant is disclosed, which involves crosslinking an amine-containing biological material such as chitosan, collagen, elastin, gelatin, fibrin glue, and combination thereof with reuterin. ... 06/09/05 - 20050123582 - Drug-eluting stent having collagen drug carrier chemically treated with genipin A method for treating vulnerable plaques of a patient, comprising: providing a biodegradable stent comprising a first supporting zone made of a first biodegradable material, wherein the supporting zone comprises at least a portion of continuous circumference of the stent; and a second therapeutic zone made of a second biodegradable ... 06/02/05 - 20050118230 - Methods and compositions for regenerating connective tissue Connective tissue regenerative compositions and methods of repairing and regenerating connective tissue using such compositions are provided. The compositions generally comprise a bioactive hydrogel matrix comprising a polypeptide, such as gelatin, and a long chain carbohydrate, such as dextran. The hydrogel matrix may further include polar amino acids, as well ... ### FreshPatents.com Support - Terms & Conditions |