Surgical Implant Or Material

Surgical Implant Or Material patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

08/02/07 - 20070178134 - Pyridines and uses thereof
The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells. ...

08/02/07 - 20070178133 - Medical device, materials, and methods
Dual thermal and photo curable materials are used for fabricating, functionalizing, and utilizing devices, such as medical devices, surgical devices, and medical implants. The materials include thermal and photo curable components that can adhere layers of the materials to one another, to other substrates, or to biologic tissues to form ...

08/02/07 - 20070178132 - Injectable chondrocyte implant
The present invention relates to a flowable implantable composition comprising a support material, such as various forms of collagen or alginate beads or threads, which can support the attachment and growth of chondrocyte cells thereto, ad a method of making a flowable implantable composition comprising a support material and chondrocytes ...

08/02/07 - 20070178131 - Medical device for insertion into human body, and method of manufacture
A medical device for insertion into the human body has improved sliding characteristics compared to similar devices with fluororesin surfaces. The medical device for insertion into the human body includes a substrate having given shape, and an agent for improving the sliding characteristics having a hydrophilic block and a hydrophobic ...

08/02/07 - 20070178130 - Cohesive osteogenic putty and materials therefor
Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients. ...

08/02/07 - 20070178129 - Bioabsorbable metal medical device and method of manufacture
A method and apparatus is provided for processing a medical device formed from a bioabsorbable metallic material. The method begins by generating a beam of radiation onto the bioabsorbable metallic material. The radiation beam is transmitted through a fluid medium and onto a heat affected zone (HAZ) of the bioabsorbable ...

07/26/07 - 20070172507 - Transluminal drug delivery methods and devices
Transluminal drug delivery method and device embodiments may include a urethral suppository formulated to treat diseases of the urethra and surrounding organs by enhancing the absorption of a therapeutic agent of the suppository into body tissues without adversely affecting the natural defense mechanisms of these tissues. Adverse affects on the ...

07/19/07 - 20070166351 - Polycationic peptides for cardiovascular therapy
Implantable medical devices including polycationic peptide coatings are disclosed. ...

07/19/07 - 20070166350 - Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for ...

07/19/07 - 20070166348 - Keratin bioceramic compositions
A malleable bone graft composition is described. The composition comprises: (a) keratose; (b) particulate filler; (c) antibiotic; and (f) water. The invention may be provided in sterile form in an container, and optionally lyophilized. Methods of treating a fracture with such compositions are also described. ...

07/19/07 - 20070166347 - Channeled endomural therapy
Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by ...

07/19/07 - 20070166346 - Method for coating an object with hydrophobin at low temperatures
The invention relates to methods for coating objects with hydrophobins. Provided is a method for providing the surface of an object with a hydrophobin coating, comprising contacting at least a part of an object with a hydrophobin-containing solution to form a hydrophobin layer on the surface of the object and ...

07/19/07 - 20070166345 - Vascular occlusion methods, systems and devices
Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures are used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment of one or more vascular occlusion devices ...

07/19/07 - 20070166344 - Non-leaching surface-active film compositions for microbial adhesion prevention
Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings with long-lasting antimicrobial efficacy without formation of a zone of inhibition. Optionally the films can be hydrophilic. Specific long-chain molecules of certain chemical reactivity are covalently bonded ...

07/19/07 - 20070166343 - Matrix, cell implantation and method for their production and use
The invention relates to porous matrices based on a biologically compatible polymer or polymer mixture, to a cell implantation that is established on said matrices and to additional cell implantation based on cell mixtures of hepatocytes and islets of Langerhans. The invention also relates to a method for producing porous ...

07/12/07 - 20070160647 - Materials for medical implants and occlusive devices
An embodiment is a swellable medical device that swells after introduction into a patient to occlude a lumen or void in a patient. The device may be anisotropically swellable so that it swells unequally in some dimensions to create an improved fit of the device into the patient. Anisotropically swellable ...

07/12/07 - 20070160646 - Stent coated by a compound
where R denotes alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl. ...

07/12/07 - 20070160645 - Postconditioning system and method for the reduction of ischemic-reperfusion injury in the heart and other organs
A postconditioning method and system for preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue. The system can exemplarily include a catheter configured for insertion therein a vessel of the subject; a means for modulating the ...

07/12/07 - 20070160644 - Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells ...

07/12/07 - 20070160642 - Implantable medical devices coated with a polymer-bound superoxide dismutase mimic
This invention relates to implantable medical devices having a coating comprising small molecule superoxide dismutase mimics bonded to biocompatible durable polymers and to uses thereof in the treatment or prevention of vascular diseases. ...

07/12/07 - 20070160641 - Coated medical devices and methods of making the same
The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that ...

07/12/07 - 20070160640 - Halofuginone delivering vascular medical devices
A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 μg and 0.2 μg of halofuginone per mm2 of stent surface area. ...

07/12/07 - 20070160639 - Drug delivery systems using mesoporous oxide films
Sustained-release drug-delivery devices employing a mesoporous oxide coating that functions as a drug reservoir, and the use of mesoporous oxide coatings for improved adhesion of organic polymers to inorganic substrates. ...

07/05/07 - 20070154517 - Methods and devices for promoting endothelial morphogenesis
In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can ...

07/05/07 - 20070154516 - Drug delivery system
A pharmaceutical composition comprises a first active (e.g., antibacterial) agent and a second (e.g., antifungal) active agent, and comprises a component that is adapted for bioadhesion to a vulvovaginal surface. The composition provides differential release of the active agents at such a surface, wherein the second active agent exhibits a ...

07/05/07 - 20070154513 - Medical devices having multiple charged layers
According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least ...

07/05/07 - 20070154512 - Low temperature drying methods for forming drug-containing polymeric compositions
The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 wt % to about 10 wt % of the total ...

07/05/07 - 20070154511 - Retention of endothelial cells on vascular grafts
An implantable device including a surface containing a plurality of first zones and a plurality of second zones depressed relative to the first zones so as to provide valleys below a plane defined by the first zones, wherein a first zone to second zone width ratio is non-random throughout the ...

06/28/07 - 20070148207 - Therapeutic inhibitor of vascular smooth muscle cells
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle ...

06/28/07 - 20070148206 - Method and systems for forming and using nanoengineered sculptured thin films
A method of forming a sculptured thin film on a surface includes rotating the surface and depositing a sculptured thin film comprised of a polymer on the surface to form submicron wires during the step of rotating. The submicron wires may be columnar, helically columnar, chevron shaped, chiral shaped, distinct ...

06/28/07 - 20070148205 - Prevention of arterial restenosis with active vitamin d compounds
The present invention relates to a method for preventing, treating, or ameliorating arterial restenosis after angioplasty in an animal by administering to the animal active vitamin D compounds. The invention further relates to a method for preventing, treating, or ameliorating restenosis after angioplasty in an animal by administering to the ...

06/21/07 - 20070141110 - Continuous phase compositions for acl repair
An implantable interference screw for use in a soft tissue repair, the screw having a bioresorbable body comprising a plurality of interconnected pores, the body having an instrument interface in one end and a thread around an exterior of the body starting from distal end. The plurality of interconnected pores ...

06/21/07 - 20070141109 - Local deliver of 17-beta estradiol for preventing vascular intimal hyperplasia and for improving vascular endothelium function after vascular injury
A device for local intracoronary delivery comprising 17-β estradiol or a derivative thereof in a dosage of 1 to 5000 μg/Kg of patient's body weight, and a pharmaceutically acceptable parenteral vehicle ...

06/21/07 - 20070141108 - Fiber-reinforced water-swellable articles
This invention provides water-swellable materials including polymeric fibers dispersed in a water-swellable polymer, and fiber-reinforced articles made from such water-swellable materials. The invention also provides a method of forming a fiber-reinforced, water-swellable material. These water-swellable materials and fiber-reinforced articles may be used in biomedical and pharmaceutical applications and may be ...

06/21/07 - 20070141107 - Progenitor endothelial cell capturing with a drug eluting implantable medical device
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical ...

06/21/07 - 20070141106 - Drug eluting implant
The present invention provides a medical system for the administration of a pharmaceutical agent in vivo to a patient. The medical system includes a medical implant positionable in a body of a patient. A pharmaceutical agent in disposed on the medical implant and at least partially coated with a reactive ...

06/21/07 - 20070141105 - Engineered biological matrices
Biocompatible matrices or implants on which one or more specific cell-interactive molecules (“biomolecules”) can be immobilized have been developed. The matrices allow for the independent control of ligand concentration and matrix strength. In one embodiment, the matrix or implant is modified with one or more moieties capable of complexing bioconjugates ...

06/21/07 - 20070141104 - Room temperature-curable polymers
Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical ...

06/21/07 - 20070141103 - Pliable medical device and method of use
A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of ...

06/21/07 - 20070141102 - Drug delivery system based on polyethylene vinylacetate copolymers
Disclosed herein is a drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic polyethylene vinylacetate copolymer. Also disclosed are a contraceptive kit or hormone-replacement therapy kit comprising the drug delivery system, and a combination preparation that simultaneously provides contraception and treatment ...

06/21/07 - 20070141101 - Method for stimulating angiogenesis and wound healing
A device comprising an extracellular matrix having an internal pH between 4.0 and 6.0 is discussed. This matrix contains heparin or a heparin-related compound such as heparan sulfate. Preferably the matrix also contains fibronectin or a fragment thereof. The matrix will bind to a protein having a pH dependent binding ...

06/21/07 - 20070141100 - Drug-eluting biodegradable stent
The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured ...

06/14/07 - 20070134291 - Composition for cartilage
Provided herein is a composition for cartilage formation or regeneration. ...

06/14/07 - 20070134290 - Drug eluting implantable medical device
A drug eluting medical device is provided for implanting into vessels or luminal structures within the body of a patient. The coated medical device, such as a stent, vascular, or synthetic graft comprises a coating consisting of a controlled-release matrix of a bioabsorbable, biocompatible, bioerodible, biodegradable, nontoxic material, such as ...

06/14/07 - 20070134289 - Polymeric stent having modified molecular structures
A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented ...

06/14/07 - 20070134288 - Anti-adhesion agents for drug coatings
Coated medical devices and methods for coating such devices are disclosed. The invention is directed to the use of an anti-adhesion agent in a coating for a medical device. More particularly, the invention is directed to a medical device comprising an anti-adhesion agent that prevents the self-adhesion of different portions ...

06/14/07 - 20070134287 - Method for coating biocompatible substrates with antibiotics
A method for coating a biocompatible substrate with an antibiotic is provided. The method includes dissolving at least one antibiotic in an antibiotic compatible solvent to provide an antibiotic solution. The antibiotic solution is applied to the substrate and the antibiotic compatible solvent is removed from the substrate. Methods of ...

06/14/07 - 20070134286 - Methods for reducing intimal hyperplasia, smooth muscle cell proliferation and restenosis in mammals
The present invention relates to methods for reducing small muscle cell proliferation, restenosis or intimal hyperplasia in mammals. ...

06/14/07 - 20070134285 - Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans
A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution comprising collagen, a calcium source and a phosphorous source and one or more glycosaminoglycans, and precipitating the collagen, the brushite and the ...

06/07/07 - 20070128249 - Osteogenic paste compositions and uses thereof
Described are osteogenic paste compositions with enhanced osteoinductive properties for use in bone repair. Compositions comprising a quickly resorbable paste carrier, a more slowly resorbed mineral matrix, and Bone Morphogenetic Protein (BMP) or other osteogenic factor are described which enable increased osteoinductive activity while retaining a reliable scaffold for the ...

06/07/07 - 20070128248 - Composite bone graft substitute cement and articles produced therefrom
The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is ...

06/07/07 - 20070128247 - Method for ionically cross-linking polysaccharide material for thin film applications and products produced therefrom
A method for producing ionically cross-linked polysaccharide material (e.g. pectin) that includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial ...

06/07/07 - 20070128246 - Solventless method for forming a coating
Provided herein are medical device having a coating substantially free from effects of drying kinetics and methods of forming the coating. ...

06/07/07 - 20070128245 - Porous calcium phosphate bone material
Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced ...

06/07/07 - 20070128244 - Bioceramic scaffolds for tissue engineering
This invention relates to a porous ceramic sphere comprising a particulate micro-porous bioinert material, in the form of spheres or scaffolds, having interconnected pores. Pores on the surface of each sphere are connected to pores inside such sphere via blow-holes and the internal pores are in turn interconnected, so that ...

06/07/07 - 20070128243 - Implantable microbial cellulose materials for various medical applications
This invention relates to polysaccharide materials and more particularly to microbial cellulose having suitable implantation properties for repair or replacement of soft tissue. The invention also relates to the use of the implantable microbial cellulose as scaffolds for tendon and ligament repair, tissue closure reinforcement, buttresses for reinforcement of the ...

06/07/07 - 20070128242 - Polymeric compositions for controlled release or delivery of pharmacologically active agents
The present invention relates to polymeric compositions for controlled release or delivery of pharmacologically active agents. Each polymeric composition comprises a biocompatible polymeric matrix containing at least one pharmacologically active agent that is susceptible to oxidative degradation. The biocompatible polymeric matrix comprises at least a first polymeric material with an ...

06/07/07 - 20070128241 - Methods, compositions, apparatuses containing tetrameric oxygen
Compositions and methods of treating conditions requiring oxygen or resulting from molecular damage induced by reactive metabolites, hypoxia or ischema. Tetrameric oxygen is administered alone as an aqueous solution or in conjunction with additional agents. Treatable conditions include cancer, viral disease, ocular disease, autoimmune, inflammatory disease and other conditions required ...

05/31/07 - 20070122447 - Shaped bodies and methods for their production and use
Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use. ...

05/31/07 - 20070122446 - Implants for treatment of symptomatic or degenerated intervertebral discs
Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, provide for the controlled release of one or more active agents into the disc. The active agent can be a chemonucleolytic agent such as chymopapain. The device can also ...

05/31/07 - 20070122445 - Absorbable fatigue-enduring phosphate composites
Precursors of fatigue-enduring phosphate composites, particularly useful as self-hardening bone cement, are formed of a calcium phosphate cement grafted with trimethylene carbonate, phosphate glass, a liquid amine-bearing derivative poly(ethylene glycol-b-propylene glycol) and a liquid C-succinylated polyalkylene glycol and preferably contain at least one bioactive agent. ...

05/31/07 - 20070122444 - Medical devices employing triazine compounds and compositions thereof
The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth ...

05/31/07 - 20070122443 - Amphiphilic copolymer compositions
The present invention provides an amphiphilic coating material for applying on at least a portion of one surface of an article. The amphiphilic coating material comprises a copolymer containing one or more alkyl methacrylate or alkyl acrylate co-monomer units; one or more vinyl acetate co-monomer units; and up to 40% ...

05/24/07 - 20070116735 - Apparatus and method for preventing adhesions between an implant and surrounding tissues
An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, such as a transplanted organ, or non-biological material such as a medical device. The membrane may be ...

05/24/07 - 20070116734 - Porous, load-bearing, ceramic or metal implant
A method and apparatus for adjusting the modulus of elasticity, flexural strength, or porosity of metal and ceramic implants is disclosed in one embodiment of the invention as including a green tape comprising metal or ceramic particles, or a combination thereof, for incorporation into a solid implant structure. Apertures are ...

05/24/07 - 20070116733 - Surface immobilised multilayer structure of vesicles
A surface-immobilised multilayer structure of a plurality of vesicles (2), said structure comprising at least one linker (4) immobilised onto said surface, said at least one linker (4) being bound to at least one other linker, which is attached to a vesicle, which optionally may have another linker (5) bound ...

05/17/07 - 20070110786 - Medical articles having enhanced therapeutic agent binding
According to an aspect of the present invention, medical articles are provided which comprise the following (a) a polymeric region having a first charge, and (b) a charged therapeutic agent having a second charge that is opposite in sign to that of the first charge. In certain beneficial embodiments, the ...

05/17/07 - 20070110785 - Medical devices with proteasome inhibitors for the treatment of restenosis
Methods, compositions and devices for inhibiting restenosis are provided. Specifically, proteasome inhibitor compositions and medical devices useful for the site specific delivery of proteasome inhibitors are disclosed. In one embodiment the medical device is a vascular stent coated with a proteasome inhibitor selected from the group consisting of a boronic ...

05/17/07 - 20070110784 - Thermally reversible implant
The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, ...

05/10/07 - 20070104758 - Biofunctional, antimicrobial coatings for medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding ...

05/10/07 - 20070104757 - Latent reactive blood compatible agents
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function ...

05/10/07 - 20070104756 - Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and augmented by inducing flacid paralysis ...

05/10/07 - 20070104755 - Method and system for treatment of eating disorders
The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric ...

05/10/07 - 20070104754 - Method and system for treatment of eating disorders
The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity ...

05/10/07 - 20070104753 - Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s)
The present invention relates generally to coated medical devices, such as a stent, that has a surface completely or partially covered with a coating that comprises a first region containing an inactive form of a therapeutic agent and a second region containing an active form of a therapeutic agent. The ...

05/03/07 - 20070098758 - Biologically absorbable coatings for implantable devices and methods for fabricating the same
Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer. ...

05/03/07 - 20070098757 - E-ptfe foil impregnated with an encapsulated bioactive substance
A method of impregnating an e-PTFE (expanded polytetrafluoroethylene) foil with a biologically-active substance. ...

05/03/07 - 20070098756 - Bone matrix compositions and methods
An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the ...

05/03/07 - 20070098755 - Tissue augmentation devices and methods
Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion ...

05/03/07 - 20070098754 - Method and article to restore function to gi or urinary tract of a patient
Method and article for restoring function to a region of a body selected from the group consisting of a gastrointestinal tract and a urinary tract of a patient. A biological agent is optionally associated with a carrier and inserted into the region of the body. The biological agent is stabilized ...

05/03/07 - 20070098753 - Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed ...

04/26/07 - 20070092549 - Water-soluble compound
A water-soluble magnetic anti-mitotic compound with a water-solubility of at least 100 micrograms per milliliter, a molecular weight of at least 150 grams per mole, a mitotic index factor of at least 10 percent, a positive magnetic susceptibility of at least 1,000×10−6 cgs, and a magnetic moment of at least ...

04/19/07 - 20070087031 - Curable bone substitute
A novel composition, kit, and method of using the composition as a bone substitute for dental, orthopedic and drug delivery purposes. Specifically, the bone substitute comprises a plurality of polymeric beads having a crosslinkable shell where the shell is cured by light and/or chemical curing. ...

04/19/07 - 20070087030 - Product for controlling dissolving rate of orthopedic implant material and process of producing the same
A product controlling dissolving rate of biomedical orthopedic implant material and a process of manufacturing the same are disclosed. At constant temperature and humidity and under vacuum, treatment solution is forced to diffuse to the material to form a second phase as a means of controlling the dissolving rate. Different ...

04/19/07 - 20070087029 - Localized delivery to the lymphatic system
The present invention provides methods for the localized delivery of an agent to the lymphatic system, including localized delivery to a lymphatic capillary bed. ...

04/19/07 - 20070087028 - Intraluminal devices for the prevention and treatment of vascular disease
An intralumen medical device comprising anti-inflamatory and anti-thrombotic or anti-coagulant drugs, agents or compounds may be utilized in the treatment of vascular disease. The intralumen medical device is selectively coated with the drugs, agents or compounds for local delivery, thereby increasing their effectiveness and reducing potential toxicity associated with systemic ...

04/19/07 - 20070087027 - Electrospun skin capable of controlling drug release rates and method
A versatile covering process enabled through the identification and manipulation of a plurality of variables present in the electrospinning method of the present invention. By manipulating and controlling various identified variables, it is possible to use electrospinning to predictably produce thin materials having desirable characteristics. The fibers created by the ...

04/19/07 - 20070087026 - Drug-eluting tissue marker
A drug-eluting tissue marker for marking a site in a tissue mass comprises a drug-eluting portion having a drug for timed release to the site and a material that can be imaged using an imaging technique. ...

04/19/07 - 20070087025 - Reiteratively layered medical devices and method of preparing same
A method for preparing a nitric oxide-releasing substrate that includes contacting an amine-functionalized silane with a substrate, contacting at least one additional amine-functionalized silane with the substrate, and contacting the substrate with nitric oxide, and repeating these steps if and as desired to produce a coating of the desired thickness ...

04/19/07 - 20070087024 - Article comprising fibers embedded in a glassy protein
The application relates to an object (30) having a plurality of elongate elements (10) embedded in a matrix (20). The matrix (20) is made from a glassy protein, preferably including serines. The elongate elements can be fibres such as polymers fibrous protein, glass fibres, carbon fibres, carbon nanotubes and montmorilonite ...

04/12/07 - 20070082022 - Latent reactive blood compatible agents
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function ...

04/12/07 - 20070082021 - Coated vaso-occlusion device
Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the ...

04/12/07 - 20070082020 - Blood clot filter having coating
The present invention is directed to a blood clot filter for implantation in a patient comprising a blood clot filter having a coating comprising one or more pharmaceutically active compounds. ...

04/12/07 - 20070082019 - Photocrosslinked hydrogel surface coatings
A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. ...

04/05/07 - 20070077276 - Multilayer films, coatings, and microcapsules comprising polypeptides
Disclosed herein is a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolye comprises a composite polypeptide comprising one or more surface adsorption regions covalently linked to one or more functional regions forming a single polypeptide chain. The surface ...

04/05/07 - 20070077275 - Multilayer films, coatings, and microcapsules comprising polypeptides
Disclosed herein are multilayer films comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more first amino acid sequence motifs has a length of 5 to 15 amino ...

04/05/07 - 20070077274 - Method for producing shaped bodies based on crosslinked gelatine
A method for producing shaped bodies based on crosslinked gelatin, which may be used as carrier material for tissue implants and have an individually adjustable degradation time, is disclosed, comrising: a) preparing an aqueous gelatin solution; b) partially crosslinking the dissolved gelatin; c) producing a shaped body starting off from ...

04/05/07 - 20070077273 - Microfabricated nanopore device for sustained release of therapeutic agent
A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication ...

04/05/07 - 20070077272 - Solid polymer delivery compositions and methods for use thereof
The present invention provides an implantable solid polymer delivery composition that can be formulated to release a bioactive agent to an interior body site at a controlled rate over an extended period of time by adjusting the various components of the composition. The controlled delivery of the composition avoids an ...

04/05/07 - 20070077271 - Medical devices coated with a fast dissolving biocompatible coating
The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body ...

04/05/07 - 20070077270 - Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
Disclosed are devices and methods for targeted delivery of therapeutic agents. The devices include selectively permeable hollow fiber membranes which allow for the outward diffusion of therapeutic agents while the contents of the device are protected from host humoral and cellular immunologic attack. The methods include implanting the devices in ...

04/05/07 - 20070077269 - Method of birth control and hormone regulation
A method of birth control and hormone regulation comprises utilizing a vaginal ring worn continuously during each menstrual cycle. A vaginal ring delivers predetermined doses of progesterone and beta-estradiol. Beta-estradiol does not cause an increase in sex hormone binding globulin and thereby does not decrease a woman's levels of free ...

04/05/07 - 20070077268 - Hydrophobic carrier modified implants for beneficial agent delivery
Disclosed is a bearing material for a medical implant or medical implant part, the bearing material comprising: (a) a matrix of crosslinked polyethylene, (b) a biocompatible hydrophobic carrier, and (c) a beneficial agent soluble in the biocompatible hydrophobic carrier. Also disclosed are methods for preparing a bearing material in accordance ...

04/05/07 - 20070077267 - Bioactive composite implants
A composite spinal implant device including collagen and/or synthetic fibers impregnated with a bioactive formulation is disclosed. Also disclosed are methods of making the composite spinal implant devices, surgeries using the device, and kits containing the device. ...

04/05/07 - 20070077266 - Drug/gene eluting stent
The present invention provides a more safe and highly effective stent having functions such as anti-inflammatory action, antithrombotic action, maintenance of tissue restoration response and maintenance of endothelial regeneration. More specifically, the drug/gene eluting stent has a layer containing a gene encoding a hybrid polypeptide on the surface. The hybrid ...

04/05/07 - 20070077265 - Article tissue systems and uses thereof
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site ...

03/29/07 - 20070071791 - Delivery system for bone growth promoting material
A delivery system that includes a bone growth promoting material encapsulated within a water absorptive gelatinizable covering is used to promote bone growth in order to repair a bone defect and/or strengthen a weakened bone region. The delivery system may be shaped and sized in order to fit within a ...

03/29/07 - 20070071790 - Biodegradable nanocomposites with enhance mechanical properties for soft tissue
The present invention is directed to a novel poly(diol citrates)-based nanocomposite materials created using completely biodegradable and biocompatible polymers that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using nanocomposites comprised of citric acid copolymers and polymers including but not limited ...

03/29/07 - 20070071789 - Bioactive material delivery systems comprising sol-gel compositions
Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed. ...

03/29/07 - 20070071788 - Skin integrated device
A skin integrated device for implantation with an improved device-skin interface for the ingrowths of skin cells and tissues throughout the pores, having a solid frame, which may also be permeable. The characteristics of pore size, porosity and size of the compressed and sintered particles constitute a long-term skin integrated ...

03/29/07 - 20070071787 - Composite material comprising a porous semiconductor impregnated with an organic substance
The invention provides a composite material comprising a porous semiconductor impregnated with at least one beneficial organic substance, wherein the beneficial organic substance is present in an amount of at least 15% by weight, based on the weight of the material. Also provided are methods for the preparation of such ...

03/22/07 - 20070065480 - Block copolymers of acrylates and methacrylates with fluoroalkenes
A block copolymer comprising a fluorinated block and a non-fluorinated block and method of making the block copolymer are provided. Also provided herein are a coating on an implantable device comprising the block copolymer and method of using the implantable device. ...

03/22/07 - 20070065479 - Therapeutic composition and a method of coating implantable medical devices
A method of making a therapeutic composition, as well as the therapeutic composition so made, is disclosed. The method comprises mixing a hydrophobic drug with an aqueous buffer solution and adding a surfactant to the aqueous buffer solution to form the therapeutic composition. A implantable medical device with the therapeutic ...

03/22/07 - 20070065478 - Polycationic peptides for cardiovascular therapy
Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes polycationic peptides, for example R7. ...

03/22/07 - 20070065477 - Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility
An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected ...

03/15/07 - 20070059335 - Seeding implantable medical devices with cells
Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction ...

03/15/07 - 20070059334 - Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E prior to irradiating the UHMWPE blend with electron beam ...

03/08/07 - 20070053953 - Method of loading beneficial agent to a prosthesis by fluid-jet application
An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a ...

03/08/07 - 20070053952 - Nitric oxide-releasing polymers derived from modified polymers
Modified polyimines and derivatives thereof suitable as implantable medical devices and coatings therefore are provided. Specifically, implantable medical devices and/or coatings comprise amphiphilic polymers derived from modified polyimines. The medical devices and coatings of the present invention can also be used for in situ nitric oxide release/controlled release drug delivery ...

03/08/07 - 20070053951 - Composite biomaterial for bone implants
Biomaterials for bone implants constituted by an inorganic phase formed by calcium salts, mainly phosphates, hydroxy- and carbonate-apatite and an organic phase formed by polymers obtained from vinyl acetate and crotonic acid. These biomaterials can be dense or porous and present different speeds of resorption when they are used as ...

03/01/07 - 20070048352 - Method for attachment of biomolecules to medical device surfaces
A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a ...

03/01/07 - 20070048351 - Drugs coated on a device to treat vulnerable plaque
A treatment for vulnerable plaque may include a device having a polymeric coating that contains a statin and/or one or more other drugs, where the statin and/or one or more other drugs may be locally released in a sustained fashion at the point of insertion of the device. The coating ...

03/01/07 - 20070048350 - Antithrombotic coating for drug eluting medical devices
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed ...

03/01/07 - 20070048349 - Surface-modified medical devices and methods of making
A surface-modified medical device comprises a hydrophilic coating that comprises units of a hydrophilic monomer and a coupling agent that has coupling functional groups, at least a portion of which is coupled to the surface functional groups of the medical device. A method for producing such a surface-modified medical device ...

03/01/07 - 20070048348 - Lubricious composites for medical devices
A medical device having at least one composite region thereon formed of composite material comprising a polymer and a fluorinated sol-gel derived ceramic. The composite material is useful as a coating material for imparting a low coefficient of friction to a substrate. ...

03/01/07 - 20070048347 - Intra-oral device for treating obesity
The present invention relates to an intra-oral device including a carrier that has an outside wall, an inside wall and an occlusal wall connecting the outside wall to the inside wall. The carrier has at least one inset and at least one insert carrying a beneficial agent that is adapted ...

02/22/07 - 20070042017 - Medical device with coating that promotes endothelial cell adherence and differentiation
Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize ...

02/22/07 - 20070042016 - Methods and systems for treating injured cardiac tissue
Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing ...

02/22/07 - 20070042015 - Coating composition for polymeric surfaces comprising serpin or serpin derivatives
The invention relates generally to a coating composition for a polymeric surface, methods for coating a polymeric surface, methods for preparing coated medical devices, polymeric surfaces coated with the coating composition, and medical devices comprising the coating composition. In particular, a coating composition for association with a polymeric surface, preferably ...

02/08/07 - 20070031469 - Dyed polymethyl methacrylate bone cement and process for its production
A dyed polymethyl methacrylate bone cement is described which is characterised by at least the surface of the polymer particles of the powder component being coated partially or completely with a mixture of one or several dyes and a hydrophobic, low molecular or oligomeric organic coupling agent, such a quantity ...

02/08/07 - 20070031468 - Modified chitosan for vascular embolization
A therapeutic composition and a method are provided for occlusion of a vascular site. The vascular site may be within a blood vessel or a lymph duct, and may include an aneurysm, an arteriovenous malformation. The composition comprises an acrylated chitosan dissolved in an aqueous medium. The composition is preferably ...

02/08/07 - 20070031467 - Composition and method for vascular embolization
A therapeutic composition and a therapeutic method are provided for occlusion of a vascular site. The vascular site may be within a blood vessel or a lymph duct, and may include an aneurysm or an arteriovenous malformation, or may be in a normal section of the vessel or duct. A ...

02/08/07 - 20070031466 - Method, apparatus and system for preventing or reducing the severity of hemorrhoids
Devices and methods for preventing or reducing the severity of hemorrhoids include a raised portion and a base, where the raised portion extends in a first direction away from the base and is shaped to engage and apply pressure to a region of a patient subject to hemorrhoids. The devices ...

02/08/07 - 20070031465 - Implant for regenerating bone or cartilage with the use of transcriptional factor
This invention provides an implant that enable satisfactory bone/cartilage regeneration by allowing sustained release of virus vectors carrying the transcription factor gene in vivo and persistent maintenance of transcription factor activity. ...

02/01/07 - 20070026038 - Method of coating a stent with a polysaccharide layer and associated stents
The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved ...

02/01/07 - 20070026037 - Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes ...

02/01/07 - 20070026036 - Drug/drug delivery systems for the prevention and treatment of vascular disease
A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of ...

02/01/07 - 20070026035 - Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one ...

02/01/07 - 20070026034 - Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one ...

02/01/07 - 20070026033 - Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one ...

02/01/07 - 20070026032 - Percutaneous access device system facilitating cell growth thereon
A biocompatible implantable portal is provided that has a wall defining a communicative passage through an interior bore. The exterior of the portal has a neck region adapted to promote autologous cell growth on the neck region. A series of channels are provided on the exterior neck region to facilitate ...

02/01/07 - 20070026031 - Composite self-cohered web materials
The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials ...

02/01/07 - 20070026030 - Method of preparing rheological materials for bone and cartilage repair
Methods of mixing delivering biocompatible cement, paste, putty, or gel for bone and cartilage repair are described in this invention. Powder-like solid materials are loaded into a first syringe. Liquids are loaded into one or multiple syringes. The liquids are injected into the first syringe containing the solid materials. To ...

02/01/07 - 20070026029 - Apheresis device
The invention relates to an apharesis device for use in the treatment of Alzheimer patients. Said device comprises a solid support with which a flow of blood or plasma can be contacted. ...

01/25/07 - 20070020310 - Self-assembled, micropatterned, and radio frequency (rf) shielded biocontainers
The present invention relates to a nanoscale or microscale container for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the container, with subsequent release of the therapeutic materials in situ, methods of fabricating the container by folding a ...

01/25/07 - 20070020309 - Safe and effective biofilm inhibitory compounds and health related uses thereof
The present invention provides compounds and materials that reduce the accumulation of microorganisms a surface, by interfering with the attachment of the organisms to the surface. The compounds and materials are thus useful in preventing the formation of biofilms on surfaces in health-related environments. By preventing the formation of biofilms, ...

01/25/07 - 20070020308 - Polymers having covalently bound therapeutic agents
Therapeutic polymers are described, which contain at least one polymeric portion and at least one therapeutic agent. The therapeutic agent and the polymeric portion are covalently linked via one or more linkages which hydrolyze in an aqueous environment, for example, one or more linkages selected from an Si—N linkage, an ...

01/25/07 - 20070020307 - Medical devices containing radiation resistant polymers
The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least ...

01/25/07 - 20070020306 - Endovascular implant with an at least sectional active coating made of radjadone and/or a ratjadone derivative
An endovascular implant, comprising an at least sectional active coating (8) in which a (re)stenosis-inhibiting substance (10) based on a ratjadone derivative is embedded. ...

01/18/07 - 20070014829 - Biocatalytic and biomimetic generation of nitric oxide in situ at substrate/blood interfaces
Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g., polyurethane, poly(vinyl chloride), silicone rubbers), metals, such as stainless steel, carbon, and the like are provided with biocatalysts or biomimetic catalysts ...

01/18/07 - 20070014828 - Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same
The invention provides a method for preparing a nitric oxide-releasing medical device. The method includes contacting an amine-functionalized silane residue with a substrate, e.g., a metallic substrate, contacting the amine-functionalized silane residue with a cross-linking agent, contacting at least one nucleophilic residue with the cross-linked amine-functionalized silane residue, and contacting ...

01/18/07 - 20070014827 - Gamma-tocopherol therapy for restenosis prevention
A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal ...

01/11/07 - 20070009571 - Novel haptotactic peptides
A group of novel peptides having a sequence selected from the group consisting of KGSWYSMRKMSMKIRPFFPQQ (SEQ ID NO:1), KTRWYSMKKTTMKIIPFNRL (SEQ ID NO:2) and RGADYSLRAVRMKIRPLVTQ (SEQ ID NO:3) are provided. Compositions and methods of use of these peptides are also provided. ...

01/11/07 - 20070009570 - Method for preparing porous polymer scaffold for tissue engineering using gel spinning molding technique
The present invention relates to a method of preparing a porous polymer scaffold for tissue engineering using a gel spinning molding technique. The method of the present invention can prepare a porous polymer scaffold having a uniform pore size, high interconnectivity between pores and mechanical strength, as well as high ...

01/11/07 - 20070009569 - Methods and compositions for the treatment and prevention of staphylococcus and other bacterial infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in which a RAP-type and/or TRAP-type molecule plays a role in pathogenesis. This includes Staphylococcus species. ...

01/11/07 - 20070009568 - Methods for immobilizing molecules on surfaces
The invention provides methods for immobilizing molecules on metallic surfaces, and compositions containing one or more surfaces that have been treated by these methods. The compositions may be used, e.g., to improve or repair cell, tissue, organ, or whole-body function. ...

01/11/07 - 20070009567 - Methods and compositions for the treatment and prevention of staphylococcal infections
Methods and compositions are provided for the treatment of staphylococcal infections. ...

01/11/07 - 20070009566 - Method and apparatus for treating bacterial infections in devices
An apparatus and method for treating or preventing bacterial colonization of medical devices, or the host itself, comprise combining an RNAIII inhibiting peptide (RIP) with the medical device, optionally with an antibiotic. Further, RIP may be used in a lock technique, comprising adding sufficient solution comprising RIP to occupy a ...

01/11/07 - 20070009565 - Functionalized chemically inert polymers for coatings
Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer. ...

01/11/07 - 20070009564 - Drug/polymer composite materials and methods of making the same
A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a compressed gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which ...

01/04/07 - 20070003591 - Use of a propolis as a coating material for medical implants
Propolis as a coating material for medical implants. It also relates to the application of propolis, particularly of the constituent caffeic acid phenylethyl ester, for the manufacture of a drug for re-stenosis prophylaxis after percutaneous transluminar coronary angioplasty (PTCA) inhuman coronary arteries. ...

01/04/07 - 20070003590 - Methods of treating microbial infections
R1, R2, R3 and R4 are selected from the group consisting of hydrogen, actinium, silicon, germanium, cyano, alkyl, alkoxy, allyl, alkenyl, alkynyl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkene, alkyne, aryl, halide, alkylhalide, alkyloxyalkyl, thioalkyl, alkylthioalkyl, alkylamino, cycloalkyl, heterocyclyl, unsubstituted or substituted; or a pharmaceutically acceptable salt thereof. The present invention further ...

01/04/07 - 20070003589 - Coatings for implantable medical devices containing attractants for endothelial cells
Provided herein is a coating that includes a chemo-attractant for endothelial cells and methods of making and using the same. ...

01/04/07 - 20070003588 - Multifunctional medical articles
The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making ...

12/28/06 - 20060292200 - Porous beta-tricalcium phosphate and methods for producing the same
Methods are provided for producing porous β-Tricalcium Phosphate (β-TCP). In the subject methods, β-TCP is combined with graphite to produce an intermediate greenware product. The intermediate greenware product is then sintered to produce porous β-TCP. The subject methods and compositions produced thereby find use in a variety of applications. ...

12/21/06 - 20060286143 - Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof
Absorbable, essentially non-absorbable, and non-absorbable crystalline, amphiphilic, block/graft copolymeric compositions exhibit an inherent viscosity of at least 0.5 dL/g, a heat of fusion of at least 10 J/g and undergo swelling in the biological environment due to a water up-take of at least 10 percent of original dry mass. These ...

12/21/06 - 20060286142 - Gold surfaces coated with a thermostable chemically resistant polypeptide layer and applications thereof
The present invention provides a method for producing biomolecular coatings on devices having gold surfaces. The method describes the production of recombinant fusion proteins consisting of one or more polypeptide domains of interest and a high affinity gold binding peptide consisting of 1 to 7 repeats of a gold binding ...

12/21/06 - 20060286141 - Systems for gel-based medical implants
Systems, including methods and apparatus, for medical implants including a gel. ...

12/21/06 - 20060286140 - Implants with attached silylated therapeutic agents
The present invention is directed to implants that include therapeutic molecules bonded to their surfaces. The therapeutic molecules interact with cells that are adjacent, near, or adhering to the implant. The covalently-bonded therapeutic molecules may be released from the implant surface by changes in pH or enzymes characteristic of cells ...

12/21/06 - 20060286139 - Polymeric drug release system for medical devices
A coating composition comprising a mixture of a poly(vinylacetal-co-vinylalcohol-co-vinylacetate) and a poly(vinylpyrrolidone-co-vinylacetate) allows a medical device to be coated with a first layer containing a first bioactive material (such as rapamycin) and a second layer containing a second bioactive material (such as dexamethasone) for release in vivo at different release ...

12/21/06 - 20060286138 - Novel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof
Novel biodegradable aliphatic polyesters derived from fatty diacids and fatty diols with even number of carbon atoms, pharmaceutical compositions and applications thereof wherein the said pharmaceutical compositions comprises at least one pharmaceutically active ingredient and the said biodegradable aliphatic polyester and the said pharmaceutical compositions is in the form of ...

12/14/06 - 20060280770 - Coating for implantable devices and a method of forming the same
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. ...

12/14/06 - 20060280769 - Terminal sterilization of injectable collagen products
Methods of sterilizing dermal fillers and injectable collagen material have been developed which reduce the level of active biological contaminants or pathogens without adversely affecting the material, i.e., wherein the dermal fillers and injectable collagen material retain their same properties before and after its terminal sterilization. In one embodiment the ...

12/14/06 - 20060280768 - Meniscal repair device and method
Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a stent. The tissue repair device is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth ...

12/14/06 - 20060280767 - In vivo grafting material
An intracorporeally implanting material comprising a composite body of a formed finely-porous or non-porous resin article, which is finely-porous, the pore diameter of which is smaller than 0.45 μm, or is non-porous and has vital tissue-blocking ability and a formed porous resin article, which is porous, the pore diameter of ...

12/07/06 - 20060275338 - Drug-eluting intravascular prostheses and methods of use
The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth factor. The device can be coated with a biodegradable drug-eluting polymer that is ...

12/07/06 - 20060275337 - Complex coacervate core micelles as surface modification or surface treatment
Complex coacervate core micelles as surface modification or surface treatment The present invention relates to devices carrying on the surface polymeric micelles and a process for the preparation thereof. It further relates to the use of polymeric micelles as a surface coating for rendering a surface anti-fouling and/or protein-resistant. The ...

12/07/06 - 20060275336 - Preparation of an osteoinductive agent
This invention relates to a method for the preparation of an osteoinductive agent, the use of such an agent, and to a kit for preparing such an agent. This invention further relates to the use of the said kit in the preparation and dispensing of such an osteoinductive agent in ...

11/30/06 - 20060269586 - Polymers of fluorinated monomers and hydrophilic monomers
A polymer blend that contains a polymer of fluorinated monomers and another biocompatible polymer. The polymer blend can form a coating on a medical device. The medical device can be used for treat, prevent or ameliorate a medical condition. ...

11/23/06 - 20060263407 - Compositions and minimally invasive methods for treating dysfunction of cardiac muscle
Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions. Particularly, delivery of platelet-rich plasma to connective tissue is described. The described method and compositions have been shown to provide both pain relief and improved mobility in treatment of lateral epicondylitis. ...

11/23/06 - 20060263406 - Implantable system for cell growth control
An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks ...

11/23/06 - 20060263405 - Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation
A bioartificial implant comprises a semipermeable barrier designed from one side to allow diffusion or prevent diffusion of predetermined substances/materials/molecules/cells/cell lines produced in the human body to the other opposite side of the barrier, and from said other opposite side to allow diffusion or prevent diffusion of predetermined substances which ...

11/16/06 - 20060257447 - Composite graft
Composite vascular grafts, their methods of construction, and methods of use are disclosed. In some embodiments, the grafts are tubular multilayer composite grafts having a luminal blood-contacting elastin layer and an outer collagen layer to impart mechanical strength to the elastin layer. The elastin and collagen layers may comprise substantially ...

11/16/06 - 20060257446 - Devices for augmentation of lumen walls
A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion ...

11/16/06 - 20060257445 - Devices for augmentation of lumen walls
A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion ...

11/16/06 - 20060257444 - Devices for augmentation of lumen walls
A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion ...

11/09/06 - 20060251700 - Adding microscopic porosity to the surface of a microcoil to be used for medical implantation
A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate ...

11/09/06 - 20060251699 - Anti-angiogenic peptides from the n-terminus of endostatin
Provided herein are anti-angiogenic comprising the N-terminal end of endostatin, nucleic acids encoding the same, pharmaceutical preparations comprising an effective amount of the peptide and nucleic acids and use of the pharmaceuticals in treating or preventing diseases or conditions associated with undesirable angiogenesis. ...

11/09/06 - 20060251698 - Device for axon and neurite growth and method for producing the same
The present invention relates to a device for directing and accelerating the growth of neuronal axon or neurite. The invention accelerates the growth speed of axon of nerve cells by using a substrate configured with a discontinuous micropattern of neuronal path-finding molecules or material thereon. The invention can reduce the ...

11/09/06 - 20060251697 - Injectable bulking compositions
According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of ...

11/02/06 - 20060246106 - Infection resistant medical implants
There is provided a medical device which is resistant to bacterial infection, especially Staphylococcus infection. The device is at least partially coated or impregnated with a composition comprising rifampicin and tobramycin. The medical device can be a vascular graft, vascular patch or a heart valve. The device can include 0.05 ...

11/02/06 - 20060246105 - Coatings on medical implants to guide soft tissue healing
Embodiments include coatings or surface treatments for medical instruments, devices, and/or implants that promote soft tissue healing. More particularly, embodiments relate to treating portions of instruments, devices, and implants where tissue healing is desired with tissue healing promoting treatments. ...

11/02/06 - 20060246104 - Stable rgd peptidomimetic composition
Disclosed herein are a chemical composition of 2-amino-6-[(2-amino-5{guanidine}pentanoyl)amino]hexanoic acid (AAGPAHA) and a method of making it. The pharmaceutical composition includes AAGPAHA and a pharmaceutical excipient. Such a composition is used in cell attachment in culture, as a coating of biomaterials and implants. The pharmaceutical composition of AAGPAHA can be used ...

10/26/06 - 20060240069 - Catheter assembly with bactericidal effect
A use in a medical device of at least one salt of organic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent is disclosed, and in particular for the manufacturing of an antimicrobial coating for a medical device for the prevention of bacterial infection. This is very ...

10/26/06 - 20060240068 - Pharmaceutical composition as solid dosage form and method for manufacturing thereof
The present invention relates to a novel pharmaceutical composition as a solid dosage form comprising desmopressin as a therapeutically active ingredient, and to a method for manufacturing thereof. The invention relates to a pharmaceutical composition as a solid dosage form comprising desmopressin, or a pharmaceutically acceptable salt thereof, as a ...

10/26/06 - 20060240067 - Biocompatible articles and related methods
Biocompatible articles and related methods are disclosed. ...

10/26/06 - 20060240066 - Elastin stabilization of connective tissue
A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm ...

10/26/06 - 20060240065 - Compositions for medical devices containing agent combinations in controlled volumes
The present invention generally encompasses controlled-volume materials that may, for example, be in a medical device or applied on a medical device as a coating, as well as methods of applying these materials. ...

10/26/06 - 20060240064 - Medical implants and fibrosis-inducing agents
Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue. ...

10/26/06 - 20060240063 - Medical implants and fibrosis-inducing agents
Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue. ...

10/26/06 - 20060240062 - Metal implant coated under reduced oxygen concentration with osteoinductive protein
The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of ...

10/19/06 - 20060233856 - Method for hand rejuvenation
The present invention provides a method of rejuvenating human skin by implanting a sheet formed of a pliable biocompatible material beneath the skin surface so as to generate a substantially smooth layer that augments a thickness of the skin portion. The biocompatible sheet has preferably a thickness sufficient for substantially ...

10/12/06 - 20060228392 - Nell-1 enhanced bone mineralization
This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for modulators of bone mineralization. In addition, NELL-1 can be used to facilitate repair of bone fractures and/or to generally increase ...

10/05/06 - 20060222679 - System and method for loading a beneficial agent into a medical device
A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. The loading of a beneficial agent in a paste form also provides the ability to deliver large and potentially ...

10/05/06 - 20060222678 - Biomcompatible implant coated with biocompatible fluor-hydroxyapatite and a coating method of the same
The present invention relates to a biocompatible implant coated with a biocompatible fluor-hydroxyapatite and a coating method of the same, and in particular to a method for coating a hydroxyapatite(HA) and a fluor-hydroxyapatite on a biocompatible implant Ti metal substrate having an excellent biocompatibility and mechanical pro