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Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form > Implant Or Insert Implant Or InsertImplant Or Insert patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.07/26/07 - 20070172506 - Osteochondral implant procedure A surgical procedure for preparing a damaged area of a human knee to receive at least one graft, according to which a moldable material is positioned over the damaged area and removed after it hardens. The mold is used as a template to determine the number and/or a dimension of ... 07/12/07 - 20070160638 - Hemostatic agent delivery system A hemostatic agent delivery system includes a hemostatic agent which is inert and non-reactive yet is capable of forming a stable clot when applied to an actively bleeding wound. The system also includes a delivery assembly to structure to facilitate delivery of the hemostatic agent proximate the hemorrhage site. More ... 07/05/07 - 20070154510 - Adsorbent-containing hemostatic devices The present invention utilizes a combination of a porous carrier and inorganic material is selected from the group consisting of diatomaceous earth, glass powder or fibers, precipitated or fumed silica, kaolin and montmorillonite clays, and Ca exchanged permutites to make a more effective hemostatic device to treat wounds in mammalian ... 07/05/07 - 20070154509 - Adsorbent-containing hemostatic devices The present invention utilizes a combination of a porous carrier and an adsorbent such as a molecular sieve to make a more effective hemostatic device to treat wounds in mammalian animals. These hemostatic devices provide a lower heat rise to the skin as compared to direct application of zeolites to ... 06/21/07 - 20070141099 - Coils Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed. ... 06/07/07 - 20070128240 - Compliant biocompatible packaging scheme based on niti shape memory alloys for implantable biomedical microsystems A compliant biocompatible packaging scheme, (i.e., coating) for implantable medical device, particularly implantable biomedical microsystems is provided. In accordance with the present invention, the compliant biocompatible coating includes an optional dielectric undercoating and an overcoat comprising a NiTi shape memory alloy. ... 05/10/07 - 20070104752 - Aneurysm embolization material and device The present invention includes a method for treating an aneurysm. The method includes providing a biocompatible polymeric string or hollow tube and transporting the string or hollow tube to the aneurysm. The aneurysm is filled with the string. The string is cut when the aneurysm is substantially filled. ... 02/22/07 - 20070042014 - Combination of a serotonin reuptake inhibitor and loxapine The present invention relates to the use of a combination of Loxapine and a serotonin reuptake inhibitor (SRI), for the treatment of depression and other affective disorders. ... 12/28/06 - 20060292199 - Pmma bone cement containing antibiotic/antibiotics A PMMA bone cement containing an antibiotic/antibiotics is described which is characterized in that, in the powder component, 0.1-5.0% by weight of water soluble, glasstype antibiotic/antibiotics granules with a particle diameter in the region of 50-1000 μm are contained which are built up of glass-type antibiotic/antibiotics primary particles bonded to ... 12/28/06 - 20060292198 - Porous beta-tricalcium phosphate granules for regeneration of bone tissue A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive ... 12/21/06 - 20060286137 - Kits, apparatus and methods for magnetically coating medical devices with living cells Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be ... 12/21/06 - 20060286136 - Surface treatment of biomedical implant for improved biomedical performance The invention provides a method of preparing a biomedical implant comprising the steps of providing a biomedical implant comprising a metal and having a surface, wherein the surface comprises a metal oxide layer, contacting the biomedical implant with a composition comprising an alkaline earth element, disrupting the metal oxide layer ... 11/23/06 - 20060263404 - Assembly for the preparation of a medical device having a coating comprising hydrogen peroxide The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other ... 11/09/06 - 20060251696 - Ophthalmic devices for sustained delivery of active compounds The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery ... 11/09/06 - 20060251695 - Adding microscopic porosity to the surface of a microcoil to be used for medical implantation A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate ... 11/09/06 - 20060251694 - Hydrophilic coating and a method for the preparation thereof The present invention provides a method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, involving the use of a polymer solution comprising 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance ... 11/09/06 - 20060251693 - Sugar binding surface The invention provides a method for the immobilisation of at least one type of carbohydrate molecule comprising contacting a surface with a plasma of at least one monomer to provide a plasma polymer coated surface and contacting said polymer surface with a carbohydrate molecule. ... 11/02/06 - 20060246103 - Implantable devices for the delivery of therapeutic agents to an orthopaedic surgical site Bioabsorbable drug delivery devices including modular drug delivery devices having shapes and sizes adapted to be inserted within a recess on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend ... 10/26/06 - 20060240061 - Tissue engineered blood vessels The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow. ... 10/26/06 - 20060240060 - Lubricious compound and medical device made of the same The present invention includes a lubricious polymer blend wherein at least one of the polymer materials is a water insoluble polymer and one of the materials is a lubricious water-soluble polymer. The invention includes a method of forming a desired medical device by melt mixing the selected polymers and then ... 10/26/06 - 20060240059 - Lubricious eluting polymer blend and coating made from the same The present invention relates to a drug eluting polymer blend. More particularly, the present invention relates to a medical device with a drug eluting polymer blend incorporated therein wherein the drug elution rate is controlled by cross-linking the polymer blend. Once formed, the polymer blend can be used to create ... 10/26/06 - 20060240058 - Combinatorial surface chip compositions for selection, differentiation and propagation of cells A combinatorial library high-throughput technique for varying polymer surface structures has been developed that allows rapid, efficient, and accurate investigation of the effects of microstructure, roughness, and surface chemistry on stem cell adhesion, proliferation and differentiation. Bloactive molecules, such as cytokines, growth factors, and extracellular matrix components can be attached ... 10/19/06 - 20060233855 - Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the ... 10/19/06 - 20060233854 - Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration. ... 10/19/06 - 20060233853 - Bone growth compositions and methods The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. ... 10/19/06 - 20060233852 - Prosthetic for tissue reinforcement A process for the manufacture of a prosthetic sheet with improved tissue healing characteristics useful in reinforcing tissue defects is disclosed. Generally the prosthetic may be comprised of any material that does not promote fibrosis and inflammation. In particular, the prosthetic may be comprised of non-absorbable hydrogel reinforced with fiber, ... 10/19/06 - 20060233851 - Composite bone graft material A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed. ... 10/19/06 - 20060233850 - Hydrogel bioscaffoldings and biomedical device coatings Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other ... 10/19/06 - 20060233849 - Composite bone graft material A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium phosphate compound or salt matrix material. A bioactive substance may be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone ... 10/12/06 - 20060228391 - Methods of tissue repair and compositions therefor The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, ... 10/12/06 - 20060228390 - Intravitreal implant A device and method for drug delivery is shown. In particular, a drug delivery device for implanting in an eye is shown. Advantages of drug delivery devices shown include an increased surface area allowing an increased drug dosage from a delivery mechanism such as a drug-containing coating. Another advantage of ... 10/12/06 - 20060228389 - Vascular implant device Vascular smooth muscle cells (VSMCs) adhere to and orient along micropatterned grooves having a depth of 1 to 10 μm and a width of 1 to 20 μm that are imposed on the surface of a vascular implant device. The VSMCs maintain an elongated morphology and reduced proliferation resulting in ... 10/05/06 - 20060222677 - Method of protecting sensitive molecules from a photo-polymerizing environment In one embodiment, the present invention is a substrate system of photopolymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules ... 09/28/06 - 20060216324 - Composition and method for preparing biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material ... 09/28/06 - 20060216323 - Polyurethanes for osteoimplants Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an ... 09/28/06 - 20060216322 - Feed composition and method for breeding animals The present invention relates to a feed composition which contains silver-carrying zeolite and an animal-breeding method comprising the step of administering, to an animal, the foregoing silver-carrying zeolite-containing feed composition. The feed composition has almost no influence on the useful lactobacillus, but exerts an antimicrobial effect on various kinds of ... 09/28/06 - 20060216321 - Solvent based processing technologies for making tissue/polymer composites An improved osteoimplant device and method for producing it. Bone particles are mixed with a polymer and a solvent. The mixture is formed into the shape of an osteoimplant and substantially all of the solvent is removed. The osteoimplant may be osteoinductive, osteoconductive, and load-bearing. ... 09/28/06 - 20060216320 - Composite of support matrix and collagen, and process for producing support substrate and composite A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g/m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the ... 09/21/06 - 20060210599 - High viscosity liquid controlled delivery system and medical or surgical device The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of ... 09/21/06 - 20060210598 - Resorbable structure for treating and healing of tissue defects Devices and processes (e.g., improved Plasticized Melt Flow processes (PMF) or improved Phase Separation Polymer Concentration (PSPC), etc.) used to make resorbable and non-resorbable structures for treating and/or healing of tissue defects are disclosed. Among the advantages of using these improved processes are the preservation of molecular weight and the ... 09/21/06 - 20060210597 - Prosthetic implants including ecm composite material Described are preferred prosthetic valve devices including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components ... 09/21/06 - 20060210596 - Seeding implantable medical devices with cells Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction ... 09/21/06 - 20060210595 - Device containing cytophilic islands that adhere cells separated by cytophobic regions The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The ... 09/21/06 - 20060210594 - Composite spinal nucleus implant with water absorption and swelling capabilities Embodiments relate to a spinal nucleus implant with water absorption and swelling capabilities, compositions for producing the spinal nucleus implants, and methods of preparing and using the spinal nucleus implants. The spinal nucleus implant can be created from a composition comprising a mixture of non-hydrogel polymer material and at least ... 09/14/06 - 20060204536 - Biointerface membranes incorporating bioactive agents A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen ... 09/14/06 - 20060204535 - Cell-friendly cannula and needle An improved cannula and method for making the same are disclosed. The cannula includes a lumen having a polished inner surface, and a first hydrophilic coating on the polished inner surface of the lumen. The cannula can also include a polished outer surface, and a second hydrophilic coating on the ... 09/14/06 - 20060204534 - Drug delivery system and method of manufacturing thereof Medical devices implanted or otherwise used in a mammal are made less prone to trigger adverse reactions by use of gas cluster ion-beam (GCIB) surface modification adhere various drug molecules directly into or onto the surface of medical devices, and optionally building adhered drug layers upon the first adhered layer ... 09/14/06 - 20060204533 - Drug delivery compositions and related methods A drug delivery composition includes a polymer, and one or more drugs and a bioactive polyelectrolyte complex dispersed within the polymer where the polyelectrolyte complex regulate the release of the drugs from the polymer. The bioactive polyelectrolyte complex comprises a polyelectrolyte and an oppositely charged component, wherein the polyelectrolyte and/or ... 09/14/06 - 20060204532 - Drug delivery systems and methods for modulating the fetal environment and pregnancy process Systems and Methods are described for treatment of fetal disorders, promotion of fetal health, and extension of the pregnancy period. A drug delivery system (DDS) can perform both bolus and continuous delivery of substances in accordance with sensed data reflecting the current state of a fetus. The methods and systems ... 09/07/06 - 20060198864 - Biointerface membranes incorporating bioactive agents A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen ... 09/07/06 - 20060198863 - Ceramic composition for filling bone defects The invention is directed toward a formable ceramic composition for application to a bone defect site which comprises a ceramic compound of beta tricalcium phosphate particles. The particle size ranges from about 40 microns to 500 microns and is mixed in a hydrogel carrier containing citric acid buffer, the hydrogel ... 08/31/06 - 20060193885 - Implantable biomaterial and a method of producing same The present invention relates to an implantable biomaterial and methods of producing same. In particular, the present invention relates to a method for producing an implantable biomaterial comprising (a) exposing a biomaterial to an alcohol-containing solution for at least 24 hours. ... 08/31/06 - 20060193884 - Novel biomaterial drug delivery and surface modification compositions Compositions are provided which include a polymer made at least in part from a polyoxyalkylene copolymer, such as a poloxamer. The polymer may be combined with a second component to form a blend or emulsion. The resulting composition may be utilized to form medical devices, drug delivery devices, or coatings ... 08/24/06 - 20060188541 - Coating an implant for increased bone in-growth A method of preparing an implant for bone in-growth comprising: providing a metal implant body, the metal implant body having a metal load bearing layer on an outer surface, the metal load bearing layer having a plurality of pores therein, the pores configured to promote bone in-growth into the load ... 08/17/06 - 20060182777 - Method of modulating drug release from a coated substrate A method of modulating drug release from coated substrates by modulating the drying rate of the coatings on the substrates. Each coating is a mixture of a polymer, a solvent, and drug and the method includes modulating the release rate of the drug particles from the outer surface of the ... 08/10/06 - 20060177475 - Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but ... 08/03/06 - 20060171983 - Use of vitamin d receptor activators or vitamin d analogs to treat cardiovascular disease Disclosed are pharmaceutical compositions containing Vitamin D receptor activators or Vitamin D analogs to treat, prevent or inhibit vascular disease among other conditions. The pharmaceutical compositions may also include ACE inhibitors or other agents. Also disclosed are methods of reducing PAI-1 expression by administering effective amounts of Vitamin D receptor ... 08/03/06 - 20060171982 - Deforming surface of drug eluting coating to alter drug release profile of a medical device A method is provided for altering a drug release profile of a coating of a medical device. The method includes determining the drug release profile of the coating of the medical device; determining an increased surface area necessary to alter the drug release profile to an altered drug release profile; ... 08/03/06 - 20060171981 - Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon ... 08/03/06 - 20060171980 - Implantable or insertable medical devices having optimal surface energy An implantable or insertable medical device is provided that contains at least one polymeric region which comes into contact with a subject upon implantation or insertion of the device into the subject. The polymeric region(s) contain at least one bulk polymer moiety and at least one surface-active polymer moiety that ... 07/27/06 - 20060165751 - Medicament incorporation matrix A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released ... 07/20/06 - 20060159718 - Method for the production of porous carbon-based molded bodies, and use thereof as cell culture carrier systems and culture systems The present invention relates to methods for producing carbon-based molded bodies. In particular, the present invention relates to methods for producing porous carbon-based molded bodies by carbonizing organic polymer materials mixed with non-polymeric fillers and subsequently dissolving the fillers out from the carbonized molded bodies. The present invention further relates ... 07/20/06 - 20060159717 - Three dimensional cell protector/pore architecture formation for bone and tissue constructs Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material. ... 07/13/06 - 20060153892 - Protein-resistant articles This invention relates to the reduction of interaction of biological systems with foreign substrates. Some applications require that the contact of a biological fluid with a foreign surface, such as a container for that fluid, have minimal interactions with that surface. Because the adsorption of proteins at surfaces mediates much ... 07/06/06 - 20060147487 - Smart textile vascular graft The smart textile vascular graft is used with an electrical control unit. The vascular graft includes a tube structure formed of a textile material. At least one active fiber is incorporated in the textile material. The active fiber provides electrical coupling thereof to the electrical control unit to provide for ... 07/06/06 - 20060147486 - Biodegradable dual porous scaffold wrapped with semi-permeable membrane and tissue cell culture using thereof Disclosed is a scaffold including a semi-permeable membrane on an outer surface thereof. The present invention also discloses a method of preparing a scaffold covered with a semi-permeable membrane, including loading one or more scaffolds into a mold with a predetermined form and size; and adding a semi-permeable agent and ... 06/29/06 - 20060141003 - Antifungal paints and coatings Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compositions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building ... 06/29/06 - 20060141002 - Coated implants and methods of coating A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer that promotes osseointegration. An apparatus comprising a substrate having a dimension suitable as a medical or dental ... 06/29/06 - 20060141001 - Pharmaceutical product A pharmaceutical and pharmaceutical-like product is provided. The product provides a plurality of components having active agents that are delivered in a single delivery entity or vehicle. The product allows for selective control of the release rates of each of the active agents while still being delivered in a single ... 06/29/06 - 20060141000 - Porous biodegradable polymeric materials for cell transplantation Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted ... 06/29/06 - 20060140999 - Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect The present invention relates to drug release systems which employ shape memory materials. ... 06/22/06 - 20060134168 - Coatings with crystallized active agent(s) and methods The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a ... 06/22/06 - 20060134167 - Methods of therapy with thrombin derived peptides The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the ... 06/22/06 - 20060134166 - Absorbable biocompatible materials Biocompatible carrier materials are described herein for enhanced delivery of therapeutic agents. Embodiments include materials and methods for making a biodegradable coating on a surface of a medical device by forming a biodegradable layer on at least a portion of the surface of the medical device, the layer comprising a ... 06/22/06 - 20060134165 - Polymers of fluorinated monomers and hydrocarbon monomers A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such ... 06/22/06 - 20060134164 - Th2-inducing adjuvant treatment for osteolysis Active immunization and a formulation for treating or preventing osteolysis caused by Wear Particles, comprising: a) a Th2 -inducing adjuvant, and b) Wear Particles. ... 06/22/06 - 20060134163 - Immobilizing anti-microbial compounds on elastomeric articles A method for modifying the surface chemistry of an elastomeric substrate and articles embodying the substrate is described. The method involves pre-treating the substrate surface to create active oxygen groups on the substrate for immobilizing securely an antimicrobial agent to the substrate. The active oxygen groups can react and bind ... 06/22/06 - 20060134162 - Methods for fabricating a drug delivery device A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent ... 06/22/06 - 20060134161 - Water-swellable polymers A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is ... 06/22/06 - 20060134160 - Calcium phosphate coated implantable medical devices and processes for making same This invention relates to novel calcium phosphate-coated implantable medical devices and processes of making same. The calcium-phosphate coatings are designed to minimize the immune response to the implant (e.g. restenosis in stenting procedures) and can be used to store and release a medicinally active agent in a controlled manner. Such ... 06/22/06 - 20060134159 - Device for the surgical treatment of female prolapse A device is described having a reticular or laminar structure to be surgically implanted in uro-gynaecological treatments, useful in particular for the surgical treatment of total or partial prolapse of the female pelvic organs or of prolapse of the vaginal vault. ... 06/22/06 - 20060134158 - Chitosan/acidic biopolymer hybrid fiber and culture base for animal cells It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the ... 06/22/06 - 20060134157 - Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications Tissue-compatible polymer composites characterized by a co-continuous, integrated multi-phase, three-dimensional microstructured network of two or more immiscible biocompatible polymers. ... 06/15/06 - 20060127440 - Drug delivery systems for the prevention and treatment of vascular diseases Provided are drug delivery systems for the prevention and treatment of proliferative diseases, particularly vascular diseases, comprising rapamycin or a rapamycin derivative having mTOR inhibiting properties, optionally in conjunction with one or more active co-agents. ... 06/15/06 - 20060127439 - Medical assembly suitable for long-term implantation and method for fabricating the same A process for fabricating a medical assembly having a medical device at least a portion of which is formed of inorganic material is provided. The medical assembly is suitable for substantially long-term implantation in a host animal. The process includes modifying a surface of the medical device to form a ... 06/15/06 - 20060127438 - Compositions and methods for coating medical implants Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant. ... 06/15/06 - 20060127437 - Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids A semisolid system and combination semisolid, multiparticulate system for controlling biological fluids is provided which includes a body fluid control composition. The body fluid control composition is adapted for utilization both as an independent mixture for direct topical application to body tissue for human or veterinary application and for incorporation ... 06/08/06 - 20060121079 - Medicament and method of treatment of patients with heavy metals A method of treatment of a diseased patient in which a dose of at least one heavy metal is delivered to the patient, with a surface area which is accessible for direct contact with the patient's tissue and effects release of heavy metal ions for uptake by immuno reactive cells. ... 06/08/06 - 20060121078 - Antimicrobial medical device According to the present invention there are provided antimicrobial catheters and other medical devices having controlled release of an antimicrobial metal or metal ion. Specifically, antimicrobial catheters and other medical devices manifest antimicrobial properties as a result of the incorporation therein of antimicrobial microcapsules comprising an inorganic antimicrobial agent and ... 06/08/06 - 20060121077 - Method for treating patients with implants of islets which have been kept in long term, in vitro culture The invention relates to the use of macrobeads which have been kept in in vitro storage for long term culture, i.e., for at least about 8 months. The macrobeads surprisingly exhibit continued efficacy in producing therapeutically useful materials. The fact that the macrobeads can be used after long term culture ... 06/08/06 - 20060121076 - Orienting polymer domains for controlled drug delivery The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising ... 06/01/06 - 20060115512 - Metallic structures incorporating bioactive materials and methods for creating the same Disclosed herein are methods to create medical devices and implantable medical devices with an electrochemically engineered porous surface that contains one or more bioactive materials to form bioactive composite structures. The bioactive composite structures are prepared using electrochemical codeposition methods to create metallic layers with pores that can be loaded ... 06/01/06 - 20060115511 - Porous structures, and methods of use The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MPa. The present invention also provides methods for making ... 05/25/06 - 20060110424 - Ceramic and metal compositions A novel metal/ceramic hybrid material in which the void space of the ceramic is filled with metal. The metal may be bonded to the ceramic, for example by formation of a metal oxide. The metal may be introduced into the ceramic as small particles in a suspension then heated to ... 05/25/06 - 20060110423 - Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. ... 05/25/06 - 20060110422 - Conversion of calcite powders into macro- and microporous calcium phosphate scaffolds for medical applications Disclosed is a method for forming carbonated calcium hydroxyapatite. The disclosed method can be used for forming bone cements or optionally cast, cured scaffolds such as may be used in many medical applications, including as implants for bone damage caused by, for instance, trauma, disease, or surgical excision due to ... 05/18/06 - 20060105012 - Pro-fibrotic coatings Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials. ... 05/18/06 - 20060105011 - Method and apparatus for computer-aided tissue engineering for modeling, design and freeform fabrication of tissue scaffolds, constructs, and devices A process and apparatus are provided for manufacturing complex parts and devices which utilize a CAD environment to design a part or device to be created (FIG. 1); Boolean, scaling, smoothing, mirroring, or other operations to modify the CAD design; a software interface to convert the CAD designed part (Data ... 05/18/06 - 20060105010 - Bladder implant The invention prevents the occurrence of bladder infections by means of a silver-doped bladder implant that, upon placement at the entry of the bladder, results in the elimination of up to 95% of the germs arriving in the bladder via the urethra. The device not only prevents the occurrence of ... 05/11/06 - 20060099237 - Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), ... 05/11/06 - 20060099236 - Coated stents The invention provides novel compositions and methods related to stents, such as coronary stents, comprising avicins, which are triterpene saponin compositions. In particular aspects of the invention, the avicins have growth-inhibiting properties and/or anti-inflammatory properties. In specific embodiments of the invention, the stent comprising the avicin reduces at least in ... 05/11/06 - 20060099235 - Medical devices and compositions useful for treating or inhibiting restenosis Medical devices and related methods for making and using same suitable for treating or inhibiting restenosis are proved. Specifically, compositions and methods for I kappa B alpha (IkBα)nuclear factor kβ (NFkβ) complex breakdown inhibition are provided. One embodiment includes a CRM-1 protein binding composition such as leptomycin B. Another embodiment ... 05/11/06 - 20060099234 - Implant containing cultured cartilage cells and method for producing this implant In order to regenerate joint defects in the human or animal body, the invention provides an implant that is placed in the joint area. Said implant is comprised of a supporting body and, in fact, is particularly comprised of a spongy bone of human or animal origin, has infiltrating channels ... 05/04/06 - 20060093639 - Method and device for destroying body tissue In general, the invention is directed to devices and methods for destroying targeted body tissue. A hydrogel implant, configured to be implanted in a target tissue, includes an associated chemical agent, such as a proteolytic chemical agent. When implanted in the targeted tissue, the implant expands and discharges the chemical ... 04/27/06 - 20060088569 - Sheet for guiding regeneration of mesenchymal tissue and production method thereof To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, ... 04/27/06 - 20060088568 - Implantation of tissue bulking devices One or more tissue bulking devices are implanted to bulk a structure within a patient. The tissue bulking devices may be implanted between the structure and an adventitial layer that at least partially covers the structure, or within the adventitial layer. In some embodiments, the structure is a luminal wall ... 04/27/06 - 20060088567 - Method of manufacturing a medical device having a porous coating thereon Methods of manufacturing drug-coated medical devices having a porous coatings thereon. The pores are created by solid particle additives added to a mixture comprising a solvent, a drug, and a polymer to create a suspension, which is applied to the medical device. The method includes adding a surfactant to the ... 04/27/06 - 20060088566 - Method of controlling drug release from a coated medical device through the use of nucleating agents A coated medical device have a drug and a nucleating agent thereon. Also provided are methods of increasing or decreasing the size of drug particles on a coated substrate through the use of nucleating agents to thereby increase or decrease the release rate of the drug from the coated substrate. ... 04/27/06 - 20060088565 - Device having osteoinductive and osteoconductive properties The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and ... 04/20/06 - 20060083767 - Surgical prosthesis having biodegradable and nonbiodegradable regions A prosthesis for repairing a hernia includes an adhesion-resistant biodegradable region and an opposing tissue-ingrowth biodegradable region. When the prosthesis is implanted into the patient, the adhesion-resistant biodegradable region covers a fascial defect of the hernia, and the tissue-ingrowth biodegradable region is located above the adhesion-resistant biodegradable region while being ... 04/06/06 - 20060073181 - Medical material made of titianium fiber It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions is provided. As a result, the time required for the formation of a stereoscopic bond can be shortened and, ... 03/30/06 - 20060067968 - Bioactive agent release coating A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The ... 03/30/06 - 20060067967 - Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures ... 03/30/06 - 20060067966 - Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time. ... 03/23/06 - 20060062822 - Medical devices to treat or inhibit restenosis Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of aldose reductase (AR) inhibitors are disclosed. Preferred AR inhibitors are enumerated. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated ... 03/23/06 - 20060062821 - Polycationic peptide coatings and methods of making the same Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes. ... 03/23/06 - 20060062820 - Metallic structures incorporating bioactive materials and methods for creating the same Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive ... 03/16/06 - 20060057180 - Tunable nonfouling surface of oligoethylene glycol An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer, preferably by the process of surface-initiated polymerization of monomeric units thereon, with each of the monomeric ... 03/16/06 - 20060057179 - Therapeutic polyesters and polyamides Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided. Medical implants based ... 03/09/06 - 20060051391 - Device for the controlled administration of substances to be inserted in a body cavity Device for the controlled administration of substances to be inserted in a body cavity, characterized by: an anchoring medium allowing for a firm anchorage of the device in said body cavity; at least one substance support medium for the release of at least one substance into the body cavity following ... 03/09/06 - 20060051390 - Medical devices having self-forming rate-controlling barrier for drug release Therapeutic-agent-releasing medical devices are provided herein, which contain a rate controlling release region that includes a biodisintegrable agent and a biostable low glass transition temperature polymer. Upon contact (e.g., implantation or insertion) of the medical device with a subject, at least the surface of the release region becomes depleted of ... 02/23/06 - 20060039947 - Biologically active implants This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as ... 02/23/06 - 20060039946 - Drug eluting medical device Medical devices configured to be implanted in two or more tissues simultaneously are discussed. A therapeutic agent is disposed on, in, or about at least a portion of an external surface of a medical device configured to be placed in one tissue, but not on, in or about a surface ... 02/16/06 - 20060034885 - Medical use of aglycon geniposidic acid The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured ... 02/16/06 - 20060034884 - Coated medical device having an increased coating surface area The present invention is directed to a coated medical device for delivering a biologically active agent to a body tissue such as a body lumen, said coated medical device having an increased coating surface area for adjusting the release rate of a biologically active agent, such as a drug, from ... 02/16/06 - 20060034883 - Composite stent with polymeric covering and bioactive coating A composite expandable stent for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. A porous imprevious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer ... 02/09/06 - 20060029635 - Growth hormone formulations A multi-dosage, storage stable liquid human growth hormone formulation consisting essentially of growth hormone in isotonic phosphate buffered solution, a preservative and a non-ionic surfactant, wherein isotonicity of the phosphate buffered solution is provided by a compound selected from the group consisting of a neutral salt, a monosaccharide, a disaccharide, ... 02/09/06 - 20060029634 - Porous structures A polyelectrolyte multilayer can be deposited on a surface and converted to a porous structure by aqueous processing. The porous structure can be loaded with a compound. ... 02/09/06 - 20060029633 - Biological patch for use in medical procedures A method for forming a patch using a laminated material and a process for forming the laminated material. Also a plurality of patches using the laminated material for various implantation purposes into an anatomy. In addition, an implant method for implanting one or a plurality of the selected patches for ... 01/26/06 - 20060018944 - Polycationic peptide coatings and methods of coating implantable medical devices Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed. ... 01/26/06 - 20060018943 - Antimicrobial material for implanting in bones The invention relates to an antimicrobial material for implanting in bones and for coating or producing an implant or an implantable medical device, whereby particles formed from an antimicrobial material are remotely dispersed inside a matrix material that forms a matrix when hardened. In order to improve the compatibility of ... 01/26/06 - 20060018942 - Polymeric microbeads having characteristics favorable for bone growth, and process including three dimensional printing upon such microbeads The invention includes a method of three dimensional printing comprising manufacturing microbeads by an emulsion solvent extraction/evaporation process, followed by three dimensional printing onto powder layers comprising the microbeads. The invention also includes polymeric microbeads containing a bioactive substance or Active Pharmaceutical Ingredient, particularly a substance which stimulates the formation ... 01/26/06 - 20060018941 - System and method for injecting liquid drug containing biological material A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity. ... 01/19/06 - 20060013850 - Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein ... 01/19/06 - 20060013849 - Medical devices containing radiation resistant block copolymer The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant block copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprise (a) a release region and (b) at ... 01/12/06 - 20060008498 - Nano-particle production Larger particles (e.g., larger than 100 μm) of a material are processed to generate smaller particles having dimensions smaller than 200 nm. At least a portion of the processing is performed under a cryogenic condition and based on at least a physical property of the material under the cryogenic condition. ... 01/12/06 - 20060008497 - Implantable apparatus having improved biocompatibility and process of making the same An implantable apparatus has a plurality of fixed and detoxified protein layers formed in situ overlying at least one surface to improve biocompatibility. A process of making the implantable apparatus can include repeatedly exposing at least one surface of the implantable apparatus to a protein solution to form a multi-layered ... 01/05/06 - 20060002966 - Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets. ... 12/22/05 - 20050281855 - Process for preparing a cross-linked carboxyl polysaccharide and the cross-linked carboxyl polysaccharide A process for preparing a cross-linked polysaccharide comprises providing a polysaccharide with free carboxyl and hydroxyl groups capable of forming an intermolecular ester bond and cross-linking the polysaccharide by using onium salt, phosphonium salt, uronium salt or carbenium salt and in the presence or in the absence of organic base ... 12/15/05 - 20050276836 - Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises a mucoadhesive composition comprising a therapeutical and/or health-promoting agent. ... 12/15/05 - 20050276835 - Photo-reactive polymer platform for use in biomedical devices where m is 0 to 10000 and n is 0 to 10000. The polymer may be used in a coating such as on a biomedical device. The polymer is an adhesion promotor for a drug delivery system wherein the polymer is coated onto a substrate such that it may be ... 11/03/05 - 20050244449 - Silicon substituted oxyapatite The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0<x<1.0. ... 11/03/05 - 20050244448 - Diagnosis and treatment of disorders of collagen and elastin metabolism This application discloses methods for diagnosing and treating SUI. The treatment methods are directed to inhibiting elastolysis in affected tissues and correcting imbalances in the expression of elastase enzymes and their inhibitors. ... 11/03/05 - 20050244447 - Novel drug dosing regimen A process for administering to an animal progressively increasing doses of one or more biologically active agents which are released over a predetermined period of time from a delivery means which is administered to an animal on a single occasion. ... 10/20/05 - 20050232961 - Deployment actuation system for intrafallopian contraception Contraceptive methods, systems, and devices generally improve the ease, speed, and reliability with which a contraceptive device can be deployed transcervically into an ostium of a fallopian tube. The contraceptive device may remain in a small profile configuration while a sheath is withdrawn proximally, and is thereafter expanded to a ... 08/25/05 - 20050186239 - Implantable sensors and implantable pumps and anti-scarring agents Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent (e.g., a cell cycle inhibitor) in order to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal. ... 08/18/05 - 20050181005 - Implantable sensors and implantable pumps and anti-scarring agents Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent (e.g., a cell cycle inhibitor) in order to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal. ... 08/18/05 - 20050181004 - Intravascular devices and fibrosis-inducing agents Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices ... 08/11/05 - 20050175657 - Medical implants and fibrosis-inducing agents Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue. ... 06/09/05 - 20050123579 - System for treating heart disease and cardiovascular disease in diabetic and non-diabetic patients The present invention is a system capable of improving the dietary fuel capabilities of diabetics and metabolically impaired patients and correct an overutilization of free fatty acids associated with heart and cardiovascular disease in diabetic and non-diabetic patients. The current invention is the treating of heart disease and cardiovascular disease ... ### FreshPatents.com Support |