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Drug, Bio-affecting And Body Treating Compositions > Antigen, Epitope, Or Other Immunospecific Immunoeffector (e.g., Immunospecific Vaccine, Immunospecific Stimulator Of Cell-mediated Immunity, Immunospecific Tolerogen, Immunospecific Immunosuppressor, Etc.) > Bacterium Or Component Thereof Or Substance Produced By Said Bacterium (e.g., Legionella, Borrelia, Anaplasma, Shigella, Etc.) > Toxin Or Toxoid, Except Endotoxin (e.g., Exotoxin, Enterotoxin, Etc.) > Clostridium (e.g., Clostridium Tetani, Etc.) Clostridium (e.g., Clostridium Tetani, Etc.)Clostridium (e.g., Clostridium Tetani, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.07/26/07 - 20070172497 - Bont/a peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides. ... 07/26/07 - 20070172496 - Conjugates of amyloid proteins as vaccines for amyloid-related diseases New conjugates comprising fragments of amyloid proteins, which may be used in vaccines for the treatment, prevention and/or amelioration of diseases associated with deposition of amyloid proteins, such as, e.g. Alzheimers disease. Methods for treating, preventing and/or ameliorating amyloid-related diseases, by administering a conjugate comprising fragments of an amyloid protein ... 07/19/07 - 20070166332 - Clostridial toxin activatable clostridial toxins The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate ... 07/12/07 - 20070160633 - Methods for enhancing therapeutic effects of a neurotoxin The present invention relates to methods for enhancing the therapeutic effects of a neurotoxin, e.g., a botulinum toxin, where the methods comprise a “wash-down” (e.g., a decreased intake) of a current pain medication and an administration of a neurotoxin. In some embodiments, the present inventions relates to methods for enhancing ... 07/05/07 - 20070154493 - Method of treating skin needing botulinum toxin type a treatment A treatment regimen for treating skin subject to a botulinum toxin type A cosmetic procedure involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition. ... 06/28/07 - 20070148189 - Stable liquid formulations of botulinum toxin The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1-2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of treatment using such formulations for various therapeutic and ... 06/07/07 - 20070128228 - Buttock deformity treatment Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock deformity or to the vicinity of a buttock deformity. ... 06/07/07 - 20070128227 - Multi-step therapy for injured muscles Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle. ... 06/07/07 - 20070128226 - Methods of treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot Disclosed is a method for treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot of a mammal comprising administering a therapeutically effective amount of neuromuscular toxin to the mammal. Preferred embodiments include administering neuromuscular toxins capable of inhibiting pain, e.g. botulinum toxin, to treat such abnormalities ... 05/24/07 - 20070116724 - Compositions and methods of topical application and transdermal delivery of botulinum toxins without reduced non-toxin proteins This invention relates to novel compositions of botulinum toxin that can be applied topically for various therapeutic, aesthetic and/or cosmetic purposes. The compositions may include botulinum toxin complexes, wherein the amounts of hemagglutinin, non-toxin non-hemagglutinin and/or exogenous albumin are selectively and independently reduced compared to conventional commercially available botulinum toxin. ... 05/24/07 - 20070116723 - Topically applied clostridium botulinum toxin compositions and treatment methods Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied directly to the skin by a patient as needed to suppress his or her hyperhidrosis, bromhidrosis, chromhidrosis, nevus sudoriferous, acne, seborrhiec dermatitis or other glandular condition. In ... 05/17/07 - 20070110769 - Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting ... 05/10/07 - 20070104737 - Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates ... 04/12/07 - 20070082013 - Use of botulinum toxin for producing drug for preventing or treating final phase of lung troubles The invention relates to the use of botulinum toxin for producing a drug for preventing or treating the final phase of lung troubles. ... 04/05/07 - 20070077259 - Compositions and methods for topical application and transdermal delivery of botulinum toxins Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations ... 03/22/07 - 20070065463 - Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions The invention is directed to topical formulations and methods of treating a migraines and/or cluster headaches, muscle sprains, muscle spasms, spasticity, tension headaches, tension related migraines and related conditions associated with muscle tension and pain with a therapeutically effective amount of an ergot alkaloid, skeletal muscle relaxant, serotonin agonist, combinations ... 03/15/07 - 20070059326 - Escherichia coli-derived vaccine and therapy against botulism A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture ... 03/01/07 - 20070048335 - Methods for treating pain and hyperhidrosis Agents for treating pain and for treating hyperhidrosis are disclosed. The agent comprises a light chain of a botulinum toxin or a fragment thereof and an alpha-2 adregenergic receptor pan agonist. ... 03/01/07 - 20070048334 - Use of a botulinum toxin to improve gastric emptying and/or to treat gerd Methods for treating gastric disorders, such as GERD and delayed gastric emptying, by intramuscular administration of a botulinum toxin to a head, neck and/or shoulder muscle of a patient with a gastric disorder. ... 02/15/07 - 20070036828 - Group b streptococcus vaccine This application relates to improved Group B Streptococcus (“GBS”) saccharide-based vaccines comprising combinations of GBS polysaccharides with polypeptide antigens, and vice versa, such that the polypeptide and the saccharide each contribute to the immunological response in a recipient. The combination is particularly advantageous where the saccharide and polypeptide are from ... 02/01/07 - 20070026019 - Botulinum toxin compositions A high potency botulinum toxin pharmaceutical composition comprising two excipients (such as albumin and sodium chloride) in a weight to weight ratio of between about 1 and about 100. ... 01/25/07 - 20070020295 - Controlled release neurotoxin system and method A botulinum toxin system for in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. ... 01/25/07 - 20070020294 - Use of botulinum toxin for treatment of articular pathologies Use of botulinum toxin to obtain a product intended to be administered intramuscular with lissive effect in treating articular pathologies, particularly coxarthrosis, or arthrosis of the hip, epicondylitis of the elbow and rotator muscle cap pathology of the shoulder. ... 01/18/07 - 20070014816 - Method for treating a trigeminal neuralgia by peripheral administration of a neurotoxin Methods for treating a trigeminal neuralgia by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... 01/11/07 - 20070009555 - Botulinum toxin and the treatment of primary disorders of mood and affect The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders comprising the administration of a neurotoxin. ... 01/11/07 - 20070009554 - Biologically active hemagglutinin from type a clostridium botulinum and methods of use An isolated, biologically active 33 kDa hemagglutinin purified from the type A Clostridium botulinum neurotoxin complex and its uses are described. ... 12/21/06 - 20060286127 - Treatment of autoimmune disorder with a neurotoxin Methods of treating one or more autoimmune disorders include a step of administering a Clostridial neurotoxin, such as a botulinum toxin, to a patient that has an autoimmune disorder. In one aspect, a method includes a step of administering the neurotoxin to the thymus gland or near the thymus gland ... 12/07/06 - 20060275327 - In vivo modulation of neuronal transport The invention relates to means for in vivo delivery of a composition into the human or animal central nervous system or spinal cord, wherein the composition comprises a non-toxic, proteolytic fragment of tetanus toxoid in association with at least a molecule having a biological function, and said molecule is capable ... 12/07/06 - 20060275326 - Method for treating hyperalgesia by peripheral administation of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... 12/07/06 - 20060275325 - Method for treating allodynia by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... 11/30/06 - 20060269575 - Botulinum toxin pharmaceutical compositions formulated with recombinant albumin A botulinum toxin pharmaceutical composition comprising a botulinum toxin and a non-pasteurized recombinant albumin. In some embodiments, the pharmaceutical composition comprises a reduced amount of recombinant albumin aggregates. ... 11/30/06 - 20060269574 - Method of repairing tendons by surgery A method of repairing tendons by surgery is provided in which the muscle associated with the tendon to be repaired is treated with a predetermined dose of a neurotoxin sufficient to effectively cause temporary paralysis of the muscle. Any other muscle inextricably linked to that tendon may also be subjected ... 11/30/06 - 20060269573 - Methods for treating peritoneal adhesions Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion. ... 11/23/06 - 20060263390 - Modified saccharides, conjugates thereof, and their manufacture Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, —C(O)— or —OC(O)—; R1 is selected from H or C1-C6 alkyl; L is a C1-C12 alkylene ... 11/16/06 - 20060257430 - Methods of modulating intracellular degradation rates of toxins The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin ... 11/02/06 - 20060246093 - Implant analog The present invention disclosures a method of stabilizing masticatory forces during re-mineralization around dental implants. The method includes installing a dental implant and injecting botulism toxin into masticatory muscles. ... 10/26/06 - 20060240043 - Methods and compositions for treating migraine pain The present invention provides novel methods and compositions for the treatment and prevention of headaches, vascular headaches, migraine headaches, cluster headaches, and migraine. One of the headaches, vascular headaches, migraine headaches, cluster headaches, and migraine treated by the methods and compositions of the invention is migraine. ... 10/19/06 - 20060233836 - Methods for identifying inhibitors of botulinum neurotoxins A system and method for identifying a botulinum neurotoxin inhibitor employing a botulinum neurotoxin substrate complex having a peptide substrate, preferably SNAP-25, a reporter domain on one side of said peptide substrate and an immobilization domain on the opposite side of said peptide substrate. The botulinum neurotoxin inhibitor is identified ... 10/05/06 - 20060222667 - Apparatus for treating asthma using neurotoxin Apparatus for providing intrabronchial delivery of neurotoxins to control the effects of asthma comprises a shaft having proximal and distal ends and a neurotoxin applicator assembly disposed on the distal end. The neurotoxin applicator assembly comprises a deployable needle assembly, a rotating needle assembly, and a needle-less injection assembly or ... 10/05/06 - 20060222666 - Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting ... 09/28/06 - 20060216313 - Methods for treating a stricture with a botulinum toxin Methods of treating a urethral stricture in a patient. The methods can include the step of administering an therapeutically effective amount of a botulinum toxin directly to a urethra of the patient, for example by use of a stent from which the botulinum toxin can elute or diffuse, thereby treating ... 09/21/06 - 20060210589 - Methods for treating myofascial pain A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G. ... 09/14/06 - 20060204524 - Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a ... 08/24/06 - 20060188525 - Transdermal botulinum toxin administration for the treatment of spastic muscle pain Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied ... 08/17/06 - 20060182767 - High-potency botulinum toxin formulations The present invention provides improved formulations of botulinum toxin that increase delivery of the botulinum toxin to neural and associated tissues and exhibit a higher specific neurotoxicity and higher potency (in LD50 Units) than available formulations of botulinum toxins. These improved formulations enable physicians to treat a wide variety of ... 08/17/06 - 20060182766 - Stabilized protein compositions for topical administration and methods of making same A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition comprises collagen, elastin, sphingoside and cerebroside. Also provided are pharmaceutical or cosmetic formulations comprising an effective amount of an active agent and the stabilizing composition as well as methods ... 08/03/06 - 20060171963 - Targeted delivery of botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the nerve endings of the trigeminal nerve, the occipital nerve and the intranasal terminals of the parasympathetic fibers originating in the Sphenopalatine ... 07/13/06 - 20060153877 - Remedies for dissease with hypermyotonia An M toxin of type A botulinum toxin (HA-negative substance) and a mixture of L toxin and LL toxin (HA-positive substance) are compared and examined in inhibitory action for neuromuscular transmission and therapeutic index. As a result, it is found that M toxin of type A botulinum toxin has characteristics ... 07/13/06 - 20060153876 - Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, ... 07/06/06 - 20060147471 - Compositions, methods and devices for preparing less painful botulinum toxin formulations Devices, methods and kits are disclosed for preparing and administering less-painful formulations of Botulinum toxin. The devices, methods and kits of the present invention are comprised of or use an acidic formulation of Botulinum toxin, or, in certain embodiments, a freeze- or flash-dried composition of Botulinum toxin, having a long ... 06/22/06 - 20060134140 - Compositions and methods for treating tumor spreading Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a ... 06/15/06 - 20060127417 - Methods for treating restenosis with a botulinum neurotoxin The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease. ... 06/08/06 - 20060121057 - Methods for treating headache The present invention features methods for selecting a patient with an enhanced therapeutic response to a botulinum toxin treatment of a headache. In some embodiments, the methods comprise the step of identifying a patient who is not using a prophylactic headache pain medication, a patient who is overusing an acute ... 06/08/06 - 20060121056 - Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby reduce or preferably prevent the transmission of afferent pain signals from peripheral to central pain fibres. They comprise a galactose-binding ... 05/25/06 - 20060110410 - Recombinant toxin fragments A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the ... 05/25/06 - 20060110409 - Targeted agents for nerve regeneration A conjugate, for delivery of a therapeutic agent to a neuronal cell, comprises the therapeutic agent, a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the binding domain is HC of botulinum C1 toxin or is ... 05/18/06 - 20060104995 - Methods for treating headache The present invention features a method for treating a headache in an acute pain medication overuse patient. In some embodiments, the method comprises the step of local administration of a botulinum toxin to a patient who is an acute pain medication overuse patient, thereby both countering a headache exacerbation caused ... 05/18/06 - 20060104994 - Clostridial toxin pharmaceutical composition containing a gelatin fragment A botulinum toxin pharmaceutical formulation comprising a botulinum toxin and a low molecular weight recombinant or native gelatin fragment suitable for administration to a human patient, and methods for treating patients with various diseases and afflictions using the formulation. ... 05/11/06 - 20060099227 - Polysaccharide containing botulinum toxin pharmaceutical compositions and uses thereof This invention relates to the use of a composition comprising a polysaccharide and a botulinum toxin for reducing a skin wrinkle. In some embodiments, the polysaccharide comprises disaccharides. In some embodiments, the average molecular weight of a disaccharide unit of the polysaccharide is between about 345 D and about 1,000 ... 05/04/06 - 20060093625 - Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting ... 05/04/06 - 20060093624 - Botulinum toxin for treating muscle contracture The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin. ... 04/20/06 - 20060083758 - Treatment of premenstrual disorders Methods for preventing or treating a premenstrual disorder by peripheral administration of a botulinum toxin. The botulinum toxin can be administered to or to the vicinity of a trigeminal sensory nerve, thereby preventing or treating one or more of the symptoms of a premenstrual disorder. ... 04/13/06 - 20060078571 - Methods for treating inflammation pain The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin component and a substance P component to a patient, thereby treating the neurogenic inflammation pain. ... 03/30/06 - 20060067950 - Clostridial neurotoxins for use in wound healing Naturally occurring and/or modified Clostridium neurotoxins, including those neurotoxins free of complexing proteins which naturally form complexes with Clostridial neurotoxins, are used to enhance healing of injured surface or superficial tissue of a patient by local administration into or in close proximity to the injured tissue. Such neurotoxins may be ... 03/23/06 - 20060062808 - Inactivation of smooth muscle tissue Treatment and procedures for treating bodily conduits involves deactivating, killing, or otherwise treating smooth muscle tissue of the conduit. ... 03/16/06 - 20060057166 - Methods for treating raynaud's syndrome Methods for treating Raynaud's syndrome by administering a botulinum toxin directly to an afflicted tissue of a patient. ... 03/16/06 - 20060057165 - Clostridium botulinum toxin formulation and method for reducing weight A method of altering taste sensation in an individual is provided, the method comprising administering an effective amount of botulinum toxin to the taste cells of the individual. The method can be used to effect reduced caloric consumption in an individual in need of reduced caloric consumption or to effect ... 03/09/06 - 20060051377 - Stretch mark treatment Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark. ... 02/23/06 - 20060039930 - Methods for enhancing wound healing A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three ... 02/23/06 - 20060039929 - Chimera botulinum toxin type e The present invention relates to a toxin comprising a modified light chain of a botulinum toxin type E, wherein the modified light chain comprises amino acid sequence PFVNKQFN (SEQ ID NO: 144) at the N-terminus, and amino acid sequence xExxxLL (SEQ ID NO: 112) at the C-terminus, wherein x is ... 02/02/06 - 20060024331 - Toxin compounds with enhanced membrane translocation characteristics The present invention relates to a compound comprising a toxin linked to a translocator. Non-limiting examples of toxins of the present invention are botulimum toxin, butyricum toxin, tetani toxins and the light chains thereof. In some embodiments, the translocator of the present invention comprises a protein transduction domain. ... 01/26/06 - 20060018931 - Therapeutic composition with a botulinum neurotoxin The present invention pertains to pharmaceutical compositions which comprise a botulinum neurotoxin from Clostridium botulinum, the neurotoxin being free of the complexing proteins naturally present in the botulinum neurotoxin complex or being chemically modified or being modified by genetic manipulation. Moreover the pharmaceutical compositions of the instant invention have good ... 12/22/05 - 20050281846 - Therapy for injured muscles Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle. ... 12/15/05 - 20050276820 - Leucine-based motif and clostridial neurotoxins Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods ... 12/01/05 - 20050266029 - Methods for treating pain associated with arthritis A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G. ... 11/24/05 - 20050260231 - Methods for treating neoplasms A method for treating a mammary gland disorder, including hyperplasic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue. ... 11/24/05 - 20050260230 - Leucine-based motifs and enhanced biological persistence of clostridial neurotoxins Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. ... 11/03/05 - 20050244435 - Recombinant toxin fragments Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said ... 10/27/05 - 20050238669 - Animal product free system and process for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... 10/27/05 - 20050238668 - Media for clostridium bacterium and processes for obtaining a clostridial toxin Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal ... 10/27/05 - 20050238667 - Botulinum toxin pharmaceutical compositions with enhanced potency with regard to a reference botulinum toxin pharmaceutical composition A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation. ... 10/27/05 - 20050238666 - Methods of enhancing stem cell engraftment The present invention provides improved methods and pharmaceutical compositions for enhancing stem cell engraftment, comprising the administration of an effective amount of a modulator of RhoGTPases. ... 10/27/05 - 20050238665 - Soluble recombinant botulinum toxin proteins The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A, type B and type E toxin proteins are provided. Methods which allow for the isolation of recombinant proteins free of significant endotoxin contamination are provided. The soluble, endotoxin-free recombinant proteins are ... 10/27/05 - 20050238664 - Botulinum toxin pharmaceutical compositions with multiple stabilizers A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation. ... 10/27/05 - 20050238663 - Recombinant stabilizer botulinum toxin pharmaceutical compositions A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation. ... 10/06/05 - 20050220821 - Pressure sore treatment Methods for treating a pressure sore or for preventing development of a pressure sore by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a pressure sore or to a pressure point, or to the vicinity thereof. ... 10/06/05 - 20050220820 - Treatment of holocrine gland dysfunction with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to control holocrine gland dysfunction in humans is provided. In preferred embodiments the methods provide beneficial effects in humans. ... 09/29/05 - 20050214328 - Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders Methods of treating, preventing, correcting and/or managing skin diseases or disorders characterized by overgrowths of the epidermis, keratoses, scleroderma, cutaneous vasculitis, acne or wrinkles are disclosed. Specific embodiments encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in ... 09/29/05 - 20050214327 - Neurotoxin-containing suppositories and related methods A botulinum toxin system for in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. The system may be a suppository effective in treating one or more anorectal disorders or conditions, such as anal fissures, hemorrhoids, anismus, and the like. ... 09/29/05 - 20050214326 - Amino acid and zinc containing botulinum toxin pharmaceutical compositions A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation. ... 09/29/05 - 20050214325 - Compositions and methods to increase the effect of a neurotoxin treatment The present invention discloses compositions and methods for enhancing the effect (e.g., duration) of a neurotoxin treatment. The compositions herein include neurotoxins and neuron growth inhibitors. Such compositions are administered locally to treat or prevent conditions, such as dermatological conditions, urological conditions, thyroid conditions, optical conditions, and neurological conditions. ... 09/22/05 - 20050208076 - Botulinum toxin pharmaceutical composition with enhanced potency A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions with the formulation. ... 09/22/05 - 20050208075 - Methods of using botulinum toxin for the treatment of hypervolemic lip deformity (lip ectropion) The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished using the disclosed methods thereby producing a favorable effect on a hypervolemic lip deformity. In other embodiments of the invention, the methods disclosed ... 09/15/05 - 20050202047 - Methods of treating abnormalities of the first metatarsophalangeal joint of the foot Disclosed is a method for treating abnormalities of the first metatarsophalangeal joint of the foot of a mammal comprising administering a therapeutically effective amount of neuromuscular toxin to the mammal. Preferred embodiments include administering toxins capable of interfering with the connection between muscle and nerve, e.g. botulinum toxin, to the ... 09/08/05 - 20050196414 - Compositions and methods for topical application and transdermal delivery of botulinum toxins A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and ... 09/01/05 - 20050191321 - Methods for treating headache A headache can be treated more effectively by co-administration of a botulinum toxin and a triptan drug to a patient and/or the effectiveness of a triptan medication can be increased. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the ... 09/01/05 - 20050191320 - Methods for treating pain and for treating a medication overuse disorder An acute pain medication overuse disorder (such as a medication overuse headache disorder) can be treated by administration of a botulinum toxin to a patient. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of where a patient ... 08/18/05 - 20050180995 - method to improve grafted hair growth and retain grafted hair This invention is a method for improving the growth and retention of any type of hair graft or hair transplant on the scalp of a human patient. The method comprises the step of administering a presynaptic neurotoxin into the scalp of the patient in a quantity and concentration to provide ... 08/11/05 - 20050175637 - Methods for enhancing wound healing A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three ... 08/11/05 - 20050175636 - Transdermal patch for botulinum toxin administration Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied ... 08/04/05 - 20050169942 - Novel dna sequences of the botulinum neurotoxin complex of clostridium botulinum type a-hall (allergan) strain for production of therapeutics This invention broadly relates to recombinant DNA technology, molecular biology, neuroscience, and medicine. Particularly, the present invention features novel sequences of the toxin and non-toxin components of the Clostridium botulinum toxin type A-Hall (Allergan) strain complex as well as the expression vector system in a heterologous organism and methods to ... 07/28/05 - 20050163809 - Remedy for hypermyotonia A remedy for muscle hyperactivity, comprising a purified botulinum neurotoxin as an active ingredient. ... 07/14/05 - 20050152925 - Method for treating pain by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... 07/14/05 - 20050152924 - Methods for treating sinus headache A sinus headache can be treated by administration of a botulinum toxin to a patient. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of a sinus membrane of a patient with a sinus headache. ... 07/14/05 - 20050152923 - Methods for treating vascular disorders Methods for treating vascular disorders by administering a botulinum toxin directly to a blood vessel of a patient. ... 07/07/05 - 20050147626 - Botulinum toxin treatments of neurological and neuropsychiatric disorders Methods for preventing or treating neuropsychiatric disorder and/or a neurological disorder including a neurological disorder mediated by the thalamus. Neuropsychiatric disorders and/or a neurological disorders, including a thalamically mediated disorder can be treated by peripheral administration of a botulinum toxin to or to the vicinity of a trigeminal sensory nerve, ... 07/07/05 - 20050147625 - Botulinum toxin treatment for kinesia Methods for treating kinesia (motion sickness) by local administration of a Clostridial toxin, such as a botulinum toxin, to a cranial or neck area of a patient susceptible to motion sickness. ... 06/30/05 - 20050142150 - Botulinum toxin formulations The invention provides for the use of a presynaptic neurotoxin (for example a bacterial neurotoxin such as botulinum toxin A) for the manufacture of a medicament for the treatment of cerebral palsy in juvenile patients. The juvenile patients are preferably juveniles of up to 6 years in age. ... 06/16/05 - 20050129716 - Therapeutic use of botulinum toxins types a and b A method of treating a patient suffering from a disease, disorder or condition includes the administration to the patient of a therapeutically effective amount of botulinum toxin of a selected serotype until the patient experiences loss of clinical response to the administered botulinum toxin and thereafter administering to the patient ... 06/09/05 - 20050123567 - Botulinum toxin therapy for skin disorders Methods for treating skin disorders by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a skin disorder. ... ### FreshPatents.com Support - Terms & Conditions |