FREE patent keyword monitoring and additional FREE benefits. http://images1.freshpatents.com/images/triangleright (1K) REGISTER now for FREE triangleleft (1K)
FreshPatents.com Logo    FreshPatents.com icons
Monitor Keywords Patent Organizer File a Provisional Patent Browse Inventors Browse Industry Browse Agents

Binds Antigen Or Epitope Whose Amino Acid Sequence Is Disclosed In Whole Or In Part (e.g., Binds Specifically-identified Amino Acid Sequence, Etc.)

Binds Antigen Or Epitope Whose Amino Acid Sequence Is Disclosed In Whole Or In Part (e.g., Binds Specifically-identified Amino Acid Sequence, Etc.) patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

Related Categories:

Drug, Bio-affecting And Body Treating Compositions


Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material > Binds Antigen Or Epitope Whose Amino Acid Sequence Is Disclosed In Whole Or In Part (e.g., Binds Specifically-identified Amino Acid Sequence, Etc.)



Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines
05/28/15 - 20150147329 - The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections....

High-affinity monoclonal antibodies to glypican-3 and use thereof
05/28/15 - 20150147330 - Described herein is the identification of a panel of high affinity monoclonal antibodies that bind GPC3. The disclosed antibodies recognize native GPC3 on the surface of cancer cells, as well as soluble GPC3. The highest affinity antibody (YP7) was further characterized and shown to be highly sensitive in that it...

Neutralising antibody molecules having specificity for human il-17
05/28/15 - 20150147331 - The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule....

Bordetella outer-membrane protein antigens and methods of making and using the same
05/28/15 - 20150147332 - An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need...

Anti-rspo antibodies and methods of use
05/28/15 - 20150147333 - Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same....

Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
05/28/15 - 20150147334 - The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of...

Interferon antagonists, antibodies thereto, and associated methods of use
05/21/15 - 20150139999 - Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists...

Tlr3 binding agents
05/21/15 - 20150140000 - Disclosed herein are anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies....

Novel antibody specific for clec14a and uses thereof
05/21/15 - 20150140001 - Provided is an antibody specifically binding to the CTLD (C-type lectin like domain) of clecl4a (C-type lectin domain family 14, member A), a method for preparing the antibody, a composition for suppressing angiogenesis comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition...

Use of a pcsk9 inhibitor to treat hyperlipidemia
05/21/15 - 20150140002 - The present invention provides methods for treating hyperlipidemia in patients who are not on statin therapy. The methods of the present invention comprise administering to a patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred...

Anti-alpha-synuclein antibodies and methods of use
05/21/15 - 20150140003 - The invention provides anti-human alpha-synuclein antibodies and methods of using the same....

Methods of treating and preventing staphylococcus aureus infections and associated conditions
05/14/15 - 20150132310 - The present invention relates to methods of treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection a subject that involves administering a CD11b inhibitor. The present invention further relates to a non-human transgenic animal expressing human CD11b and its use in methods of identifying...

Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
05/14/15 - 20150132311 - The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to TL1A. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of...

Monoclonal antibodies and methods of use
05/07/15 - 20150125453 - This disclosure relates to immunogens and monoclonal antibodies useful in the identification and/or treatment of cancer cells, including those of the dog. In one example, chimeric anti-canine CD20 antibodies are provided. The antibodies can be used therapeutically to treat lymphoma in dogs....

Anti-fgfr2 antibody
05/07/15 - 20150125454 - The present invention provides an antibody which binds to a fibroblast growth factor receptor....

Antibodies directed to angiopoietin-2 and uses thereof
05/07/15 - 20150125455 - Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the...

Colon disease targets and uses thereof
05/07/15 - 20150125456 - The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as...

Bone repair promoter
05/07/15 - 20150125457 - The present invention provides a bone repair promoter containing as an active ingredient at least one kind of B-type natriuretic peptide receptor agonist....

Anti-ccl17 antibodies
05/07/15 - 20150125458 - The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing....

Apelin peptides, antibodies thereto, and methods of use
05/07/15 - 20150125459 - The present disclosure concerns the use of biologically active apelin peptides and compositions that are processed from larger precursor proteins and further post-translationally modified to influence cell growth. Particular methods are useful for promoting cell growth, while others are particularly useful for inhibiting cell growth....

Anti-bcma antibodies
05/07/15 - 20150125460 - This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for depleting naïve B cells, plasma cells, and memory B cells, and for treating B cell-related disorders, including lymphomas and autoimmune...

Mecp2 isoform-specific antibody for detection of endogenous expression of mecp2e1
04/30/15 - 20150118235 - An antibody that binds a MeCP2E1 isoform of MeCP2 protein, wherein the antibody comprises a region comprising the amino acid sequence of SEQ ID NO:4. A method for detecting and/or monitoring a disease or a disorder caused by an over-expression or an under-expression of a MeCP2E1 isoform of MeCP2 protein,...

Method for predicting the risk of getting a cardiovascular event in a female subject
04/30/15 - 20150118236 - Subject of the present invention is a method for predicting the risk of getting a cardiovascular event in a female subject comprising determining the level of pro-neurotensin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said female subject; and correlating said level of...

Anti-human cd69 antibody, and use thereof for medical purposes
04/30/15 - 20150118237 - The present invention provides an antibody that specifically binds to human CD69, has an activity to suppress allergic inflammation, and has cross-reactivity with mouse CD69. In addition, the present invention provides an antibody having high binding affinity for human CD69 and an activity to suppress allergic inflammations. The antibody of...

Anti-c-met antibodies
04/30/15 - 20150118238 - The present invention relates to antibodies, or antigen-binding fragments thereof, that bind to the extracellular domain of human c-Met, compositions and kits comprising such c-Met antibodies, or antigen-binding fragments thereof, and methods of using the same for detection of human c-Met that aid in identifying patients with tumors expressing or...

Conformational-specific antibodies against a[beta] oligomers
04/30/15 - 20150118239 - The present disclosure relates to a conformational specific antibody molecule recognizing a conformational epitope of human trimeric or tetrameric oligomers, wherein said antibody molecule does not bind human monomeric Aβ 1-42 or human Ap 1-42 dimers; and pharmaceutical and diagnostic compositions comprising said antibody molecule as well as methods using...

Anti-fcrn antibodies
04/30/15 - 20150118240 - The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA....

Lingo-2 antagonists for treatment of conditions involving motor neurons
04/30/15 - 20150118241 - The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition...

Hepatitis c virus neutralizing antibody
04/30/15 - 20150118242 - A specific epitope on the surface of the hepatitis C virus that induces a neutralizing antibody response in vivo and neutralizing monoclonal antibodies that bind specifically to the epitope are disclosed. The antibodies block hepatitis C virus from infecting cells....

Methods and compositions for identifying, diagnosing, and treating neuroblastoma
04/30/15 - 20150118243 - Methods and compositions for identifying, diagnosing, and treating neuroblastoma are disclosed....

Anti-transferrin receptor antibodies and methods of use
04/23/15 - 20150110791 - The present invention relates to anti-transferrin receptor antibodies and methods of their use....

Anti-tim-1 antibodies and uses thereof
04/23/15 - 20150110792 - Antibodies and antibody fragments that bind to human TIM-1 on the BED face of the protein are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit or reduce TIM-1 binding to phosphatidylserine, inhibit or reduce TIM-1 binding to dendritic cells, and treat or prevent immunological...

Humanized anti-epiregulin antibody, and cancer therapeutic agent comprising said antibody as active ingredient
04/23/15 - 20150110793 - The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue...

Anti-human cytomegalovirus antibodies and use thereof
04/23/15 - 20150110794 - This disclosure provides anti-human cytomegalovirus antibodies and methods of treatment, prophylaxis, detection, and diagnosis using the same. In another aspect, the disclosure features therapeutic, prophylactic, and/or diagnostic compositions for human cytomegalovirus infection or for a human cytomegalovirus-related disease that include a binding agent (e.g., antibody) or polynucleotide disclosed herein. In...

Antibodies or fragments thereof for use in the treatment of ocular diseases
04/23/15 - 20150110795 - Antibodies for use in the treatment and/or prevention of retinal diseases, in particular a retinal disease that curses with dysfunction of the external blood-retinal barrier, the dysfunction being an alteration or impairment of the blood-retinal barrier for any etiology. Pharmaceutical and veterinary compositions are also disclosed in which the antibodies...

Biological materials related to cxcr7
04/23/15 - 20150110796 - The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes....

Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
04/23/15 - 20150110797 - Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the peptides. Pharmaceutical compositions including the peptides and antibodies and methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders....

Anti-human folate receptor beta antibodies and methods of use
04/23/15 - 20150110798 - Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FRβ....

Anti-c.difficile toxin antibodies and associated methods
04/16/15 - 20150104454 - Embodiments of the invention are directed to a composition comprising a recombinant protein in soluble form wherein said recombinant protein comprises a portion of the Clostridium difficile toxin B sequence that comprises an epitope for anti-toxin B antibody. Other embodiments of the invention are directed to the generation of antibodies...

Methods and compositions for treating and diagnosing acute myocardial infarction
04/16/15 - 20150104455 - Compositions and methods for treating and diagnosing acute myocardial infarction are described. The invention also provides a method of treating an individual to prevent or inhibit damage to myocardial tissue from an acute myocardial infarction comprising administering to the individual an antibody to BMP-1-3, or an antibody to BMP-1-4, or...

Antagonists of il-17 isoforms and their uses
04/16/15 - 20150104456 - The invention relates to antagonists of IL-17 isoforms and their uses in diagnosis and therapy, especially for the treatment or prevention of cancers or autoimmune and chronic inflammatory diseases....

Il-17 antagonist antibodies
04/16/15 - 20150104457 - The disclosure relates to antibodies against human IL-17 which act as antagonist antagonists of IL-17, and their use in the diagnosis or treatment of IL-17 mediated diseases....

House dust mite allergen
04/16/15 - 20150104458 - A polypeptide containing an amino acid sequence having at least 60% identity to the amino acid sequence SEQ ID No. 1 or containing at least one amino acid fragment of at least 6 consecutive amino acid residues of the amino acid sequence SEQ ID No. 1 or having immunological cross-reactivity...

Compositions and methods for the therapy and diagnosis of influenza
04/16/15 - 20150104459 - The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides....

Anti-robo4 antibody
04/09/15 - 20150098945 - The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the...

Compositions and methods for the diagnosis and treatment of tumor
04/09/15 - 20150098946 - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid...

Monoclonal olfml-3 antibodies and uses thereof
04/09/15 - 20150098947 - Provided herein are monoclonal antibodies against Olfml-3. In some aspects, methods for treating angiogenesis-related conditions, such as cancer, are provided comprising administering an Olfml-3-binding antibody of the embodiments....

Clostridium difficile antigens
04/02/15 - 20150093389 - The present invention relates to recombinant Clostridium difficile antigens based on a polypeptide, consisting of or comprising an amino acid sequence having at least 80% sequence identity with an amino acid sequence consisting of residues 1500-700 of a C. difficile Toxin A sequence or a C. difficile Toxin B sequence;...

Humanized and chimeric anti-factor bb antibodies and uses thereof
04/02/15 - 20150093390 - A method of inhibiting complement activation mediated by Bb inhibitors in a subject includes administering a Bb inhibitor to the subject to inhibit at least one of Bb binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation...

Oncostatin m (osm) antagonists for preventing cancer metastasis and il-6 related disorders
04/02/15 - 20150093391 - A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM...

Antibodies
04/02/15 - 20150093392 - The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to CDH17 with high affinity. Nucleic acid molecules encoding CDH17 antibodies, expression vectors, host cells and methods for expressing CDH17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CDH17 antibodies are also provided. Methods for...

Anti-activin a antibodies and uses thereof
03/26/15 - 20150086556 - The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such...

Novel integrin alpha9 beta1 ligand and uses thereof
03/26/15 - 20150086557 - (B) an amino acid sequence the same as the amino acid sequence represented by SEQ ID NO: 1 except for having deletion, substitution or addition of 1 to 3 amino acids. The novel ligand for integrin α9β1 has a higher binding affinity than those of tenascin-C and osteodontin, which are...

Anti-mige antibodies that bind to the junction between ch4 and cemx domains
03/26/15 - 20150086558 - Antibodies binding to junction regions between the CH4 and CεmX domains of membrane-bound IgE and uses thereof in treating IgE-mediated diseases such as allergic diseases....

Antibody formulation
03/26/15 - 20150086559 - Anti-CD40 antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an...

Influenza vaccine and therapy
03/26/15 - 20150086560 - The present invention is directed generally to M1 polypeptides that can be utilized as vaccines and/or antigens for generation of anti-M1 polypeptide antibodies for prophylactic treatment of individuals who are susceptible to infection by influenza virus. The anti-M1 polypeptide antibodies of the invention are useful for treatment of individuals infected...

Binding moieties for biofilm remediation
03/26/15 - 20150086561 - Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described....

Functional peptide analogs of pedf
03/19/15 - 20150079094 - The invention provides compositions and methods relating to bioactive peptide analogs of PEDF....

Preventon, treatment and diagnosis of p. gingivalis infection
03/19/15 - 20150079095 - The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases....

Method for the treatment of amyloidoses
03/19/15 - 20150079096 - The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aβ globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject....

S100a4 antibodies and therapeutic uses thereof
03/19/15 - 20150079097 - The invention relates to antibodies against S100A4, methods for the preparation of these antibodies, pharmaceutical compositions comprising these antibodies, and therapeutic and diagnostic uses thereof....

Lm-antibodies, functional fragments, lm-1 target antigen, and methods for making and using same
03/12/15 - 20150071931 - The invention provides LM-1 antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions. The invention also provides antibodies, functional fragments, modified and variant forms that bind to LM-1 antigen (e.g., NONO/nmt55). Antibodies, functional fragments, modified and variant forms, nucleic acid and other compositions are useful in treatment...

Combination therapy using c-met inhibitor and c-myc inhibitor
03/12/15 - 20150071932 - A method of preventing and/or treating a cancer including co-administering a c-Met inhibitor and a c-Myc Inhibitor to a subject in need thereof, a pharmaceutical composition comprising a c-Met inhibitor and a c-Myc inhibitor, and a kit comprising a pharmaceutically effective amount of a c-Met inhibitor as an active ingredient,...

Use of annexin a3 as a diagnostic and prognostic biomarker and therapeutic target for treating hepatocellular carcinoma
03/12/15 - 20150071933 - Annexin A3 (ANAX3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and the utilization of a monoclonal antibody against ANXA3 or antisense polynucleotide against ANXA3 mRNA for the suppression or treatment of HCC, alone or in combination with other HCC treatment. Monoclonal antibody against...

Methods for regulating hair growth disorders
03/12/15 - 20150071934 - The invention provides for methods for treating a hair loss disorder in a subject by administering a FGF13 inhibitor. The invention further provides for methods for treating a hair growth disorder in a subject by administering a FGF13 activator....

Fibrosis suppression by inhibiting integrin alpha-8 beta-1 function
03/05/15 - 20150064187 - Novel and effective anti-fibrosis agents are obtained. An anti-fibrosis agent containing an antagonist for integrin α8β1 is used. In addition, used is an antagonist containing an anti-integrin α8β1 antibody that specifically binds to at least one amino acid in a cap subdomain of an integrin α8 chain and a periphery...

Polypeptide structural motifs associated with cell signaling activity
03/05/15 - 20150064188 - Isolated polypeptides comprising or consisting essentially of specific structural motifs (e.g., three β-sheets and two α-helices) are provided, wherein the polypeptides exhibit at least one cell signaling and/or other non-canonical activity of biological relevance. Also provided are polynucleotides encoding such polypeptides, binding agents that bind such polypeptides, analogs, variants and...

Method of treating cancer with dll4 antagonist and chemotherapeutic agent
03/05/15 - 20150064189 - The invention provides methods for treating various types of cancer/tumor by administering the combination of Dll4 antagonists, in particular, Dll4 antibodies and fragments thereof that specifically bind human Dll4, and chemotherapeutic agents. Such combination therapies exhibit synergistic effects compared to the treatment with either agent alone. Thus, the methods of...

Antibodies to tumor endothelial marker 7r
03/05/15 - 20150064190 - Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors....

Anti-c-met-antibody formulations
03/05/15 - 20150064191 - Provided herein are pharmaceutical formulations comprising a one-armed, anti-c-met antibody and uses of the same....

Mammalian cell surface antigens; related reagents
03/05/15 - 20150064192 - Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided....

Advertise on FreshPatents.com - Rates & Info

###

FreshPatents.com Support - Terms & Conditions