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Drug, Bio-affecting And Body Treating Compositions > Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material

Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material

Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

08/21/14 - 20140234291 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods...

08/21/14 - 20140234292 - Process for producing a plasma protein-containing medicament
finishing the medicament....

08/21/14 - 20140234293 - Combination therapy using immunoglobulin and c1-inhibitor
Methods are disclosed for treating cerebral ischemia using a combination of C1-INH and immunoglobulin, such as human plasma derived immunoglobulin (IVIG)....

08/14/14 - 20140227249 - Screening methods and uses thereof
The present invention relates to improved screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands....

08/07/14 - 20140219995 - Inhibitors of bacterial type iii secretion system
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive...

08/07/14 - 20140219996 - Ruthenium carbon monoxide releasing molecules and uses thereof
The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been...

08/07/14 - 20140219997 - Templated islet cells and small islet cell clusters for diabetes treatment
A population of small reaggregated islets or clusters engineered from individual islet cells and having improved characteristics as compared to native isolated islets....

08/07/14 - 20140219998 - Armet as a marker for cancer
Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of...

07/31/14 - 20140212407 - Treatment of obesity
The present disclosure relates to the treatment, e.g. reduction, of body fat mass levels for example in overweight and obese subjects. The present disclosure also relates to weight control in a subject where obesity should be avoided. Disclosed herein are methods of reducing body fat mass e.g. reducing obesity or...

07/24/14 - 20140205591 - Metabolite biomarkers for diagnosis and prognosis of pediatric septic shock
The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome (SIRS). Also provided is a method of predicting pediatric septic shock mortality in a pediatric septic shock patient....

07/24/14 - 20140205592 - Stratification of cancer patients for susceptibility to therapy with ptk2 inhibitors
The present invention relates to a method for determining whether a cancer patient is susceptible to treatment with a protein tyrosine kinase 2 (PTK2) inhibitor, comprising detecting the expression of the E-cadherin protein in a cancer sample of said cancer patient, wherein an E-cadherin protein immunoreactivity score (IRS) of 0-2...

07/17/14 - 20140199289 - Use of matrix metalloproteinase inhibitors to treat tuberculosis
The present invention provides a method for treating a subject suffering from tuberculosis which comprises administering to the subject a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to treat the subject, such that the therapeutic effect of said composition is different...

07/17/14 - 20140199290 - Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods...

07/10/14 - 20140193395 - Secretory iga compositions, methods of making and methods of use thereof
Described herein is secretory IgA isolated from the intestinal luminal fluid and intestinal mucosal of animals such as pigs and cows. Also included are methods of isolating secretory IgA. The secretory IgA is useful in food compositions such as animal and human food compositions as well as pharmaceutical compositions to...

07/10/14 - 20140193396 - Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
The invention provides immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway...

07/03/14 - 20140186332 - Biomarkers of preterm birth
The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's...

07/03/14 - 20140186333 - Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular VT and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for...

07/03/14 - 20140186334 - Surface, anchored fc-bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is...

07/03/14 - 20140186335 - Certain compounds, compositions and methods
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds....

06/26/14 - 20140178360 - Novel pyrimidine compounds as mtor and pi3k inhibitors
which are useful in treating mTOR kinase- or PI3K kinase-related diseases....

06/26/14 - 20140178361 - Method for polyclonal immunoglobulin g production by human b cells
This application relates to an in vitro method of producing a polyclonal IgG preparation. The method comprises (i) placing a polyclonal B-cell population enriched in IgG-secreting B cells in a culture medium; and (ii) culturing the polyclonal B-cell population under conditions enabling the production of the polyclonal IgG preparation from...

06/12/14 - 20140161790 - Engineered immunoglobulins with extended in vivo half-life
The present application relates to immunoglobulin compositions with improved half-life, and their application, particularly for therapeutic purposes....

06/12/14 - 20140161791 - Diagnostic markers and therapeutic targets of kawasaki disease
The present invention provides for compositions and methods for diagnosing and treating Kawasaki disease. More specifically, the proteomes of patients with KD are enriched for the meprin A, filamin B, and filamin C, which serve as biomarkers (and potential therapeutic targets) for KD. Accordingly, detection of these biomarkers, using compositions...

06/05/14 - 20140154238 - Compositions and methods for treating, diagnosing and monitoring disease
Compositions and methods which inhibit the expression of the TMEM92 gene or which inhibits the function of die TMEM92 protein can be used for treating, diagnosing and monitoring disease, for example cancer....

05/29/14 - 20140147434 - Ncor1 is a physiological modulator of muscle mass and oxidative function
The present invention provides methods of increasing muscle mass and muscle mitochondrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, muscular dystrophy disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging....

05/22/14 - 20140140986 - Materials and methods for directing an immune response to an epitope
The present invention relates to compositions, kits, and methods useful for directing an immune response to an epitope of an antigen in a subject, by sensitizing the subject to the epitope and/or by tolerizing the subject to the epitope. The sensitizing method comprises co-administering to the subject the epitope and...

05/22/14 - 20140140987 - Manufacturing and purification processes of complex protein found in fraction iv to make a separated apo, transferrin, and alpha 1 anti strepsin (a1at) or a combined transferrin/apo/human albumin/a1at and all new found proteins
A method of introducing healthy good human cells to eat up bad damaged cells, comprising administering an effective amount of a healthy good protein containing transferrin, alpha 1-antitrypsin, apolipoprotein A and human albumin. The method further comprises administering an effective amount of a protein containing ApoA1/2/4, or administering an effective...

05/01/14 - 20140120079 - Compositions and methods for diagnosing and treating diabetic micro vascular complications
Disclosed herein are compositions and methods for the identification of a subject at risk for developing microvascular complications associated with diabetes such as diabetic nephropathy and diabetic retinopathy. Also disclosed is a therapeutic target for the prevention and treatment of microvascular complications associated with diabetes....

05/01/14 - 20140120080 - Method for treating or preventing an inflammatory disease and/or an autoimmune disease
The present invention relates to a method for treating or preventing either one or both of an inflammatory disease and an autoimmune disease in a patient, wherein the method comprises providing a pharmaceutical composition containing a therapeutically effective amount of soluble FcγR; administering said composition to a patient, followed by...

05/01/14 - 20140120081 - Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values...

04/24/14 - 20140112909 - Methods and formulations promoting tissue/organ regeneration, longevity and healthspan
A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound...

04/24/14 - 20140112910 - Modified glycoproteins
Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described....

03/27/14 - 20140086901 - Inhibition of post-radiation tumor growth
Compositions and methods for inhibiting the growth of solid tumors following radiation treatment are described. The compositions and methods target matrix metalloproteinases and bone marrow-derived cells expressing matrix metalloproteinases....

03/27/14 - 20140086902 - Determining immunoglobulins in non-blood body fluids of neonatal ungulates
Provided is a method for determining immunoglobulins in a neonatal ungulate. The method entails obtaining a sample of oral secretions from the neonatal ungulate and measuring an amount of immunoglobulins in the sample of oral secretions. The method is faster and more convenient than previously available methods for determining immunglobulins...

03/20/14 - 20140079688 - Methods for treating ophthalmic disorders, diseases and injuries
The invention is directed to methods for treating ophthalmic disorders, diseases and injuries. In particular, the invention is directed to treating disorders, diseases and injuries of the cornea and ocular surface. Such methods utilize novel compositions including, but not limited to, trophic factor secreting extraembryonic cells (herein referred to as...

03/13/14 - 20140072550 - Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid...

03/06/14 - 20140065132 - Diagnosis and treatment of autism spectrum disorder
Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD....

03/06/14 - 20140065133 - Jak/stat inhibitors and mapk/erk inhibitors for rsv infection
The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an inhibitor of the janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway or the mitogen-activated kinase (MAPK)/extracellular signal-regulated...

02/27/14 - 20140056871 - Anti-inflammatory antibodies and uses therefor
The invention provides antibodies that inhibit activation of complement, which may be used to treat various inflammatory diseases or disorders....

02/20/14 - 20140050718 - Methods and compositions for enhancing intranasal delivery of therapeutic agents
A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of MMP-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal...

01/30/14 - 20140030251 - Composition and method for reducing tissue damage from inflammatory disorder or pathogenic infection
Compositions and methods for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infections are described. In one aspect, a method for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infection comprises administering to a subject a therapeutically effective amount of a neuregulin....

01/30/14 - 20140030252 - Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described....

01/23/14 - 20140023635 - Single nucleotide polymorphisms and genes associated with t2d-related complications
The invention provides with means to predict, in subjects affected by type-2-diabetes (T2D), the probability of developing complications related to the disease. The invention involves (1) identification of genetic features such as single nucleotide polymorphisms (SNPs) for the establishment of a patient profile that can be used for prediction of...

01/23/14 - 20140023636 - Aminocarboxylic acid derivative and medicinal use thereof
wherein all symbols are described in the specification....

01/16/14 - 20140017226 - Treatment of multiple sclerosis with combination of laquinimod and fampridine
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject fampridine as an add-on therapy to or in combination with laquinimod. This invention also provides a package comprising laquinimod and fampridine for treating a subject afflicted...

01/16/14 - 20140017227 - Gene signatures for use with hepatocellular carcinoma
The present invention provides a method for predicting prognosis of hepatocellular carcinoma patients based on measurement of the relative level of expression of a combination of 15 immune genes of interest, or a subset thereof, in the tumors of such patients. Tumor material can come from surgical resection or biopsy....

01/02/14 - 20140004100 - Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an...

01/02/14 - 20140004101 - Smac peptidometics useful as iap inhibitors
or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals....

01/02/14 - 20140004102 - Methods for treating and/or limiting development of diabetes
The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes....

12/19/13 - 20130336957 - Novel purification of human, humanized, or chimeric antibodies using protein a affinity chromatography
Disclosed herein are compositions and methods for the isolation and purification of antibodies from a sample matrix. In particular, the present invention relates to compositions and methods for isolating and purifying antibodies exhibiting low or high binding capacity for Protein A resin. In certain embodiments, the methods herein employ a...

12/19/13 - 20130336958 - Notch inhibition in the treatment of cardiovascular disease
The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and...