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Drug, Bio-affecting And Body Treating Compositions > Enzyme Or Coenzyme Containing > Hydrolases (3. ) (e.g., Urease, Lipase, Asparaginase, Muramidase, Etc.) > Acting On Peptide Bonds (3.4) (e.g., Urokinease, Etc.) > Sh-proteinases (3.4.22) (e.g., Papain, Chymopapain, Bromelains, Ficin, Etc.)

Sh-proteinases (3.4.22) (e.g., Papain, Chymopapain, Bromelains, Ficin, Etc.)

Sh-proteinases (3.4.22) (e.g., Papain, Chymopapain, Bromelains, Ficin, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

06/14/07 - 20070134232 - Topical bite care composition
The present invention is directed to a topical bite care composition for treating insect bites. The composition contains a steroid and a proteolytic enzyme and/or an antipruritic. The composition can be applied to the skin in any liquid form over the affected area. ...

02/08/07 - 20070031401 - Catalytic domain of adam33 and methods of use thereof
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, ...

01/04/07 - 20070003541 - Methods and compositions for therapeutics
The invention encompasses composition and methods for cell culture and for therapeutic and cosmetic use. The compositions and methods utilize collagenase, e.g., bacterial collagenase, other isolated collagenase, or synthetic collagenase, e.g., recombinant collagenase. One form of collagenase that can be used in some embodiments of the invention is matrix metalloproteinase-1. ...

01/04/07 - 20070003540 - Stem cells having increased sensitivity to sdf-1 and methods of generating and using same
The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation. ...

12/07/06 - 20060275280 - Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of ...

11/23/06 - 20060263347 - Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the lyophilized composition are described herein. ...

11/09/06 - 20060251643 - Regulatory zinc finger proteins
Disclosed are chimeric zinc finger proteins that can regulate endogenous genes. Examples of such proteins include proteins that can regulate VEGF-A expression. The proteins and nucleic acid encoding them can be used to modulate angiogenesis. ...

11/09/06 - 20060251642 - Modulation of stem cells using zinc finger proteins
Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stems cells into the desired phenotype, propagating stem cells and/or facilitating cloning. ...

11/02/06 - 20060246054 - Bromelain preparation and pharmaceutical composition containing the same
The present invention relates to improved preparation of Bromelain in which the Bromelain is coated with an organic network polymer constructed by cross-linkage between organic acids and polysaccharides. The present invention also relates to a pharmaceutical composition comprising the present Bromelain preparation for treating inflammation, alleviating pains, and/or enhancing immuno-defense ...

10/19/06 - 20060233784 - Adamts13 genes and proteins and variants, and uses thereof
The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, ...

10/19/06 - 20060233783 - Topical composition in the form of a gel for treating skin burns
The present invention relates to novel topical compositions for treating burns, grazes, erythema, eczema, herpes infection, evulsion, sores and any skin damage leading to sloughing, including at least three components, namely a first barrier gel, a second barrier gel and an active principle having proteolytic activity. The novel compositions have ...

08/17/06 - 20060182737 - Wet wipes including a composition for reduction and prevention of wrinkles on the skin
Wet wipes comprising a composition for reducing and preventing wrinkles on the skin is disclosed. The composition is provided in the form of an aqueous composition comprising containing papain, urea, boric acid, preservatives, the sodium salt of 2-pyrrolidone-5-carboxylic acid, and almond extract. ...

08/17/06 - 20060182736 - Transducible dna-binding proteins
Disclosed is a chimeric protein comprising: a) a plurality of zinc finger domains; and b) a heterologous protein transduction domain, effective for translocating the protein across a cellular membrane. The chimeric protein can be efficiently transduced into cultured eukaryotic cells in which they regulate specific target genes. Thus, artificial transcription ...

08/03/06 - 20060171939 - Remedy for degenerative intervertebral discs
To treat diseases accompanied by degenerative intervertebral discs, in particular, disk herniation, lumbar pain, discopathy and osteoarthritits of the spine, it is intended to provide a drug for administering a human-origin protease directly to an affected part of such a disease accompanied by degenerative intervertebral discs. As the human-origin protease, ...

04/13/06 - 20060078555 - Intraventricular hemorrhage thrombolysis
The invention provides methods of treating intraventricular hemorrhage using thrombolytic agents. ...

03/23/06 - 20060062776 - Modified anticholinergic neurotoxins as modulators of the autoimmune reaction
Disclosed a modified and detoxified anticholinergic neurotoxic peptide that can suppress and prevent the onset of a T-cell mediated autoimmune reaction. The invention has application to the treatment of certain human autoimmune diseases, including especially multiple sclerosis, myasthenia gravis, and rheumatoid arthritis. More specifically, the method of treatment of autoimmune ...

02/16/06 - 20060034824 - Pharmaceutical composition comprising carriers for products
The present patent application refers to a new product composition comprising: BROMELINE . . . more than 0.01%. ...

01/26/06 - 20060018894 - Administration of enoxoparin sodium to patients 75 years and older with st-segment elevation myocardial infarction
Methods for treating ST-segment elevation myocardial infarction in a human patient 75 years of age or older. The methods comprise administering a dose of less than 1 mg per kg body weight, about 0.75 mg per kg of body weight, or 0.75 mg per kg of body weight of enoxaparin ...

12/22/05 - 20050281806 - Compositions for topical enzymatic debridement
Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, ...

12/01/05 - 20050265990 - Treatments and nutritional supplements for assisting post-exercise recovery
Compositions are provided for use in post-exercise recovery. An effective amount of leucine, valine and isoleucine in the ratio of 3:1:1 is administered following exercise, and thereafter on a daily basis for some days following exercise. ...

12/01/05 - 20050265989 - Non-toxic purification and activation of prothrombin and use thereof
The present invention relates to a prothrombin activator for activating prothrombin to thrombin comprising of an extract of fish gills or a combination of fish egg and fish gills. Said activator is suitable for use in medical applications as well as in food products. ...

11/10/05 - 20050249720 - Cosmetic skin formulation
A cosmetic formulation is shown which includes as a blend of ingredients natural honey as an antiseptic and a blend of natural fruits including pineapple, mango and papaya as active dermal exfoliating agents. The blend also includes at least two melons as buffering agents for the active exfoliating agents. ...

10/20/05 - 20050232915 - Matrix metalloproteinase inhibitors in combination with hypothermia and/or radiotherapy for the treatment of cancer
The invention provides a method of treating cancer in a subject in need of such treatment which comprises: radio-therapy, or cytotoxic therapy in combination with heat shock, and further comprises administering to the subject an effective amount of a matrix metalloproteinase. ...

10/13/05 - 20050226860 - Defense and counter-defense compositions and methods
Contemplated compositions and methods are directed to the use of a proteinase to reduce capsaicin-induced pain sensation in a mammal. Preferably, the proteinase comprises a bromelain preparation in a liquid formulation for topical or enteral administration. In additional aspects of the inventive subject matter, a proteinase inhibitor is present in ...

07/07/05 - 20050147601 - Regulation of cell migration and adhesion
Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene ...



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