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Drug, Bio-affecting And Body Treating Compositions > Whole Live Micro-organism, Cell, Or Virus Containing > Animal Or Plant Cell Animal Or Plant CellAnimal Or Plant Cell patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/16/07 - 20070190038 - Closed cell culture system An object of the present invention is to provide a tissue cell culture system whereby a call tissue can be efficiently and quickly proliferated in vivo and the onset bacterial infection in an injured part can be avoided in the course of a treatment. More specifically, a closed cell culture ... 08/16/07 - 20070190037 - Artificial vascular grafts, their construction and use The present relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more cell adhesion factors or one or more cell adhesion factors and one or more cell proliferation growth factors ... 08/16/07 - 20070190036 - Microencapsulation of pancreatic islets within a thin coat of glucagon-like peptide-1 functionalized poly(ethylene glycol) Microencapsulation of pancreatic islets within a thin poly(ethylene glycol) (PEG) coat is provided. The PEG coat is functionalized with an insulinotropic agent, glucagon-like peptide 1 (GLP-1). The encapsulated pancreatic islets may be used for the treatment of type I diabetes. ... 08/16/07 - 20070190035 - Diabetes treatment methods and drug targets therefor Provided are methods of treating insulin resistance or type II diabetes. Disrupting CAP in the macrophage can alter the inflammatory response associated with impaired insulin action and ultimately result in improved insulin action in target tissues. One aspect of the invention involves administering a CAP antagonist to a patient afflicted ... 08/16/07 - 20070190034 - Immunomodulation using placental stem cells The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations. ... 08/09/07 - 20070184035 - Artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity This invention relates to a bioactive artificial sintered composition for providing a morphology capable of consistently supporting bone cell activity thereon. The composition comprises stabilized calcium phosphate phases developed by the conversion of a hydroxyapatite substance in the presence of stabilizing entities at sintering temperatures into insolubilized and stabilized tricalcium ... 08/09/07 - 20070184034 - Combination pressure therapy for treatment of hypertension, blood production, and stem cell therapy Methods for administering pressure changes to a user for the treatment and prevention of diseases and conditions are disclosed herein. Methods of administering Cyclic Variations in Altitude Conditioning Sessions (CVAC Session(s)) for the treatment of hypertension, blood production, and stem cell therapy are disclosed herein. ... 08/09/07 - 20070184032 - Tissue harvesting device and method A tissue harvesting method and device for obtaining micrograft tissue particles within the size range of 50-1500 microns, and more preferably 500-1000 microns, and most preferably 600 microns. The particles may be processed after a piece of donor tissue has been excised from the donor site, or processed into the ... 08/09/07 - 20070184031 - Uses of bispecific antibody coated dendritic cells pulsed with antigens and gm-csf in immune regulation GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells ... 08/09/07 - 20070184030 - Large scale storage of viable somatic stem and/or progenitor cells A large scale storage system of viable somatic stem and/or progenitor cells for use in a method of treatment of a disease or a disorder of a patient is described. The storage system includes a large number of solid supports having cryopreserved/frozen viable somatic stem and/or progenitor cells from patients, ... 08/09/07 - 20070184029 - Method of treating cancer using platelet releasate Platelets are concentrated from the blood of a patient. The platelets are treated by a method such as ultrasound or agitation to obtain platelet releasate. This releasate as a whole or a component thereof is formulated into an injectable formulation which is administered to the same patient the platelets were ... 08/02/07 - 20070178074 - Chondrocyte culture formulations The present invention provides methods and compositions for providing graft recipients with chondrocytes. Specifically, the methods and compositions of the invention provide for populations of chondrocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of chondrocytes that exhibit great proliferation capacity. The ... 08/02/07 - 20070178072 - Method for inducing differentiation of regulatory t cells usinggip-anchored protein agonist and pharmaceutical composition therefor ( as amended An object of the present invention is to provide a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells, an immunosuppressive method using these methods, and pharmaceutical compositions for use in these methods. Furthermore, a method for inducing the differentiation of and/or promoting the proliferation ... 08/02/07 - 20070178071 - Stem-cell, precursor cell, or target cell-based treatment of multiorgan failure and renal dysfunction Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof. ... 07/26/07 - 20070172465 - Use of umbilical cord blood stem cells to treat ischemic event The invention relates generally to methods for isolation and culture of umbilical cord blood stem cells, cells isolated by the methods, and therapeutic uses for those cells. ... 07/26/07 - 20070172464 - Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation. ... 07/19/07 - 20070166290 - Lineage restricted glial precursors from the central nervous system A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from ... 07/19/07 - 20070166289 - Autologous human dna grafting - anti- & reverse aging process, method Anti-aging process and method for delivering younger human DNA to tissues, through the periodic infusion (auto-transfusion) of previously harvested autologous younger stem cells, resulting in re-establishment of an earlier relative biological clock set-point, with respect to the number of cell generations-divisions. ... 07/19/07 - 20070166288 - Formulation to improve survival of transplanted cells The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that enhance survival, and may be heat shocked prior to transplantation. ... 07/12/07 - 20070160584 - Method of bone regeneration It is an object of the present invention to provide a method for effectively regenerating bone, and more specifically to provide a method for regenerating bone that is capable of treating patients suffering from bone defect or bone injury. The present invention provides a method for regenerating bone, which comprises ... 07/12/07 - 20070160583 - Method for purifying mesenchymal stem cells The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner ... 07/12/07 - 20070160582 - Apparatus and methods for amplification of blood stem cell numbers The present invention provides an apparatus and methods for expansion of hematopoietic stem cell numbers. The stem cells are cultured and differentiated cells and endogenous growth factors are removed (depleted), permitting long term culture and expansion of the stem cells. The hematopoietic stem cells are used in numerous therapeutic procedures. ... 07/05/07 - 20070154463 - Stem cell originated from salivary gland duct epithelium and use of the same A stem cell which can be differentiated to a hepatic cell, a pancreas cell or to a salivary gland cell is disclosed. The stem cell according to the present invention is originated from salivary gland duct epithelium, which can be differentiated to an alpha-fetoprotein-positive cell, an albumin-positive cell, an amylase-positive ... 07/05/07 - 20070154462 - Augmentation and repair of tissue defects with in vitro cultured fibroblasts Certain embodiments here in are directed to a method of treating a tissue associated with a defect in a human including wrinkles, rhytids, depressed scar, cutaneous depressions, stretch marks, hyperplasia of the lip, nasolabial fold, melolabial fold, scarring from acne vulgaris, and post-rhinoplasty irregularity. The tissue defect may be treated ... 07/05/07 - 20070154461 - Tissue treatments with adipocyte cells Certain embodiments here in are directed to a method of treating a tissue associated with a defect in a human including wrinkles, rhytids, depressed scar, cutaneous depressions, stretch marks, hyperplasia of the lip, nasolabial fold, melolabial fold, scarring from acne vulgaris, and post-rhinoplasty irregularity. The tissue defect may be treated ... 07/05/07 - 20070154460 - Device and method for rapid aspiration and collection of body tissue from within an enclosed body space Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional ... 06/28/07 - 20070148143 - Human cytokine receptor Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.” ... 06/28/07 - 20070148142 - Pharmaceutical composition for treatment of wounds containing blood plasma or serum The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site. ... 06/28/07 - 20070148141 - Method of using hepatic progenitors in treating liver dysfunction Methods of using hepatic progenitors in treating liver dysfunction are provided. More particularly, methods of using hepatic progenitor cells, including hepatic stem cells, in treating liver dysfunction in the absence of immune-suppressing amounts of an immunosuppressant. ... 06/28/07 - 20070148140 - Compositions and methods to enhance viability and function of islet cells This invention uses placental alkaline phosphatase (“PALP”), and other members of the alkaline phosphatase family, to reduce the death and thereby maintain or enhance the viability and function of insulin-producing islet β-cells including insulin secretion. PALP may be administered to a patient that has received transplanted islet cells to protect ... 06/28/07 - 20070148139 - Fabrication of vascularized tissue using microfabricated two-dimensional molds A method and materials to create complex vascularized living tissue in three dimensions from a two-dimension microfabricated mold has been developed. The method involved creating a two dimensional surface having a branching structure etched into the surface. The pattern begins with one or more large channels which serially branch into ... 06/28/07 - 20070148138 - Hair follicle graft from tissue engineered skin The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention. ... 06/28/07 - 20070148137 - Regenerated corneal endothelial cell sheets, processes for producing the same, and methods of using the same The regenerated corneal endothelial cell sheet obtained by the process will adhere very well to living tissues. ... 06/21/07 - 20070141037 - Enhanced submucosal tissue graft constructs An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo. ... 06/21/07 - 20070141036 - Composition and procedure for tissue creation, regeneration and repair by a cell-bearing biological implant enriched with platelet concentrate and supplements A composition and method for enhancing tissue growth, regeneration, and repair includes a Biological Glue formed by extraction of an Extremely Platelet Rich Plasma (EPRP) derived from whole blood, and subsequent activation and clotting. The Biological Glue may be utilized alone to fill defects or may be used as an ... 06/21/07 - 20070141035 - Pluripotent olfactory stem cells Disclosed is a cultured pluripotent animal cell that is prepared from nasal polyps. Also disclosed are methods for making the cell and methods of treating a brain tissue damage or of promoting cerebral angiogenesis, cerebral neurogenesis, stem cell homing to the brain, neurotrophic factor expression in the brain. ... 06/21/07 - 20070141034 - Methods for isolating t cells and uses thereof Provided herein are methods for obtaining viable populations of T cells and enriched populations of T cells. ... 06/14/07 - 20070134211 - Differentiation of adipose stromal cells into osteoblasts and uses thereof The invention provides methods and compositions for differentiating stromal cells from adipose tissue into cells having osteoblastic properties, and methods for improving a subject's bone structure. The methods comprise culturing stromal cells from adipose tissue in β-glycerophosphate and ascorbic acid and/or ascorbate-2-phosphate for a time sufficient to allow differentiation of ... 06/14/07 - 20070134210 - Production of oligodendrocytes from placenta-derived stem cells The present invention provides methods and compositions for the production of glial cells and oligodendrocytes from placenta stem cells. The invention further provides for the use of these glia and oligodendrocytes in the treatment of, and intervention in, for example, trauma, ischemia and degenerative disorders of the central nervous system ... 06/14/07 - 20070134209 - Cellular encapsulation for self-assembly of engineered tissue Methods are disclosed of producing a cellular matrix for tissue self-assembly. Encapsulated living cells are provided, with each of the living cells separately encapsulated within a primary encapsulant. The encapsulated living cells are themselves encapsulated within a liquid or gel secondary encapsulant. The second encapsulant is polymerized. ... 06/14/07 - 20070134208 - Methods for purifying hematopoietic stem cells Described herein are methods for purifying hematopoietic stem cells. Also described herein are methods for purifying EPCR+ cells. The invention also provides substantially pure isolated hematopoietic stems cells, including EPCR+ hematopoietic stem cells. ... 06/07/07 - 20070128175 - Novel hydorgels and uses thereof The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the ... 06/07/07 - 20070128174 - Methods and compositions for organ and tissue functionality Materials and methods for treating tissue defects in human or animal tissues using implantable cells are described. Further, culture techniques and factors for enhancing these procedures, and cell survival and adaptation are described. Many of the tissue defects may be treated with autologous cells, while applications involving non-autologous cells or ... 06/07/07 - 20070128173 - Use of polysulphated alginate in cellular matrices The present invention describes an in vitro/ex vivo method for the cultivation of connective tissue cells or progenitor cells (e.g. chondrogenic cells) in matrix comprising polysulphated alginate. These cultivated cells can be used in the preparation of a medicament for the treatment or prevention of osteochondral defects. The invention also ... 06/07/07 - 20070128172 - Hair growth method A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an ... 06/07/07 - 20070128171 - Engineered blood vessels The present invention relates to engineered blood vessels and methods of making such vessels using matrices comprising endothelial and smooth muscle cells, or cells capable of differentiating into endothelial and smooth muscle cell lineages (e.g., stem cells, or the progenitors thereof). ... 05/31/07 - 20070122390 - Graft with increased resistance to enzymatic degradation Described are devices, methods, and systems for grafting tissues or organs that are exposed to bacterial or mammalian enzymes that degrade collagenous materials. Illustrative medical grafts are processed by contacting a collagenous extracellular matrix (ECM) material with a mono-carboxylic acid having from four to about twelve carbon atoms, or mixtures ... 05/31/07 - 20070122389 - Stage specific follicle maturation systems A three-dimensional matrix system is described herein. The system is used to surround developing tissue and support continued interaction between, for example, an oocyte and a supporting cellular structure. Oocytes grown to maturity can then be retrieved from the matrix for subsequent research use and/or fertilization. The systems and methods ... 05/31/07 - 20070122388 - Tissue graft compositions and methods for producing same A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for ... 05/31/07 - 20070122387 - Hair grafts derived from plucked hair The present invention is a hair graft derived from a plucked hair comprising a plucked hair having adhered epidermal stem cells and associated follicular dermal cells. The present invention also includes methods of making a hair graft, methods of implanting a hair graft and methods of identifying inductive follicular dermal ... 05/31/07 - 20070122386 - Preparation method of a hair dermal papilla cell preparation, composition and method for regenerating hair follicles, and animal having regenerated hair follicles The present invention provides a method for preparing a hair dermal papilla cell preparation comprising preparing a cell suspension by removing epidermal tissue from skin tissue and subjecting the resulting dermal tissue fraction to collagenase treatment, and cyropreserving the cell suspension to kill the follicular epidermal cells. The present invention ... 05/24/07 - 20070116685 - Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith Isolated, mammalian, bone marrow-derived, hematopoietic stem cell populations contain endothelial progenitor cells (EPC) capable of forming retinal blood vessels. At least about 50% of the cells in the isolated cell population express CD31 and c-kit. Up to about 8% of the cells can express Sca-1, and up to about 4% ... 05/24/07 - 20070116684 - Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cells by gene transfection and other means for therapeutic applications. ... 05/24/07 - 20070116683 - Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cells by gene transfection and other means for therapeutic applications. ... 05/24/07 - 20070116682 - Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cells by gene transfection and other means for therapeutic applications. ... 05/24/07 - 20070116681 - Ex vivo and in vivo methods and related compositions for generating hematopoietic stem cell populations Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production of HSCs ex vivo and in vivo by reducing latexin ... 05/24/07 - 20070116680 - Stem cells within gel microenvironments This invention provides a system to embed stem cells within three-dimensional (3D) hydrogel microenvironments consisting of naturally derived proteins, proteoglycans and/or polysaccharides. Pure matrices or combinations of materials can be used. The method involves suspending stem cells in solutions of the matrix components of interest, emulsifying these solutions in a ... 05/24/07 - 20070116679 - Augmentation of organ function The present invention provides methods and compositions for augmenting organ functions using small-scale matrix implants generated by seeding tissue-specific or undifferentiated cells onto a matrix materials (e.g., a wafer, sponge, or hydrogel). The seeded matrix composition can then be implanted and will develop into an organ-supplementing structure in vivo. Continued ... 05/24/07 - 20070116678 - Medical device with living cell sheet A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The obtained living cell sheet is administered to a joint adapted for implantation and for cartilage regeneration. ... 05/24/07 - 20070116677 - Brain tissue damages A method of treating brain tissue damage, including administering to a subject in need thereof an effective amount of secretoneurin. Disclosed are methods of promoting angiogenesis or neurogenesis in the brain of subject. Also disclosed are a method of homing of stem cells to the brain of a subject and ... 05/24/07 - 20070116676 - Method for three-dimensional cartilage tissue engineering using bone marrow cells in tissue engineering bone marrow cells in simulated microgravity environment This invention provides a method for three-dimensional cartilage tissue engineering by culturing bone marrow cells in a simulated microgravity environment that is realized by a bioreactor such as an RWV. ... 05/24/07 - 20070116675 - Drug and method for proliferating natural killer cells NK cells are obtained by administering a Toll-like receptor ligand such as polyinosinic-polycytidylic acid into the peritoneal cavity of an animal to which lactoferrin has been administered to proliferate NK cells in the peritoneal cavity and collecting NK cells from the peritoneal cavity. ... 05/24/07 - 20070116674 - Use of adipose tisue cells for initiating the formation of a fuctional vascular network The invention relates to the use of cells of a medullary or extra-medullary white adipose tissue, in particular of an extra-medullary stromal vascular fraction (SVF) and/or mature dedifferentiated adipocytes of any origin for initiating the formation of a functional vascularisation. ... 05/17/07 - 20070110732 - Use of synovium and omentum for tissue engineering A method for treating a patient to repair or regenerate damaged tissues or organs in which synovium from a joint or omentum from the abdomen are harvested to provide explants, optionally separating cells from the synovium or omentum explants for culture or tissue specification, and introducting the explants or separated ... 05/17/07 - 20070110731 - Integument cell regeneration formulation The invention relates to a composition-of-matter and method of using a topical composition having 10-99 999% by weight of a topical base formulation and other active ingredients including stem cell or growth factors and/or antioxidants, as well as others for the purpose of regenerating integument cells ... 05/17/07 - 20070110730 - Multipotent stem cells from peripheral tissues and uses thereof This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues. ... 05/17/07 - 20070110729 - Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for ... 05/17/07 - 20070110728 - Method for preventing and treating diabetes using dg119 The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a DG119-1 product or a DG119-1 agonist and/or an antagonist To a DG 119-2 product. ... 05/17/07 - 20070110727 - Multipotent stem cells isolated from umbilical cord blood and the cellular therapeutic agent comprising the same for treating ischemic disease The present invention relates to multipotent stem cells, adult stem cells isolated by culturing umbilical cord blood in a medium containing human serum or plasma, and a cellular therapeutic agent for ischemic necrosis resulting from occlusive arterial disease, which contains the multipotent stem cells as active ingredients. The multipotent stem ... 05/10/07 - 20070104695 - Breast augmentation and reconstruction system A breast template for delivering stem cell formulation to a breast defect of a patient for treating or augmenting a breast tissue defect comprising a flexible band with at least one throughput hole for guiding an injecting needle to penetrate into the breast of the patient, wherein the flexible band ... 05/10/07 - 20070104694 - Breast stimulation and augmentation system A stem-cell-seeded porous scaffold implant and electromagnetic growth stimulation for treating or augmenting a breast tissue defect in a patient. ... 05/10/07 - 20070104693 - Breast augmentation system A stem-cell-seeded porous scaffold implant and delivery systems for treating or augmenting a breast tissue defect in a patient. ... 05/10/07 - 20070104692 - Breast tissue regeneration A stem-cell-seeded porous scaffold implant and methods for treating a breast tissue defect in a patient. ... 05/10/07 - 20070104691 - Follicular fluid for prolonged growth and survival of cells for cell therapies The invention provides a method for preventing senescence and death of somatic cells by culturing the cells in the presence of serum and follicular fluid or components of follicular fluid. The somatic cells with a limited lifespan in vitro acquire properties of stem cells and can be passaged continuously, but ... 05/03/07 - 20070098699 - Process for preparing bone marrow stem cells, and composition related thereto Process for preparing a composition comprising TVEMF-expanded bone marrow stem cells, anti the composition resulting therefrom. ... 05/03/07 - 20070098698 - Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent. ... 05/03/07 - 20070098697 - Preventing transfusion related complications in a recipient of a blood transfusion This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion ... 05/03/07 - 20070098696 - Immortalized fibroblasts Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early stage mouse embryo is provided. Methods of preparing an immortalized fibroblast cell line from an early stage mouse embryo are ... 05/03/07 - 20070098695 - Methods of islet separation during isolation The present invention relates to methods for improving the viability and recovery of islets that are separated from a donor organ for subsequent transplantation. In a preferred embodiment, the islets are separated from a donor pancreas and transplanted into the liver of a diabetic patient. A protective agent is mixed ... 05/03/07 - 20070098694 - Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts. ... 05/03/07 - 20070098693 - Methods for enhancing engraftment of purified hematopoietic stem cells in allogenic recipients CD8+/TCR− bone marrow cells facilitate engraftment of hemapoietic stem cells (HSQ in allogeneic recipients without causing graft versus host disease. The present invention identifies the main subpopulation (55-65%) of CD8+/TCR− facilitating cells (FQ as plasmacytoid precursor dendritic cells (p-preDC). The present invention notably demonstrates that FC and p-preDC share many ... 04/26/07 - 20070092497 - Cytotherapeutics, cytotherapeutic units and methods for treatments using them The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells. Assurance of the nature and identities of such cells is achieved through assay and certification of said numbers and identities. Therapeutic modalities are provided. Libraries of cell preparations with assayed and preferably certified populations are ... 04/26/07 - 20070092496 - Method of delivering cells to the skin The present invention is a method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed from the hair follicle progenitor cells. The present invention is also a method of forming new ... 04/26/07 - 20070092495 - Methods for regulating differentiation of neural cells and uses thereof The present invention provides methods for promoting or suppressing differentiation of neural stem/progenitor cells, for producing differentiated neural cells, and for isolating/purifying differentiated neural cells. Also provided are differentiated neural cells, cell populations and transgenic animals comprising same, and uses of same. The present invention further provides methods for treating ... 04/26/07 - 20070092494 - Composition for wound healing using lyophilized skin or skin-derived collagen A wound healing composition for repairing a wound in a human or animal subject, comprising a first skin tissue material and a carrier comprising collagen derived from a second skin tissue material. Methods of making the wound healing composition and methods of augmenting a wound site with the composition are ... 04/26/07 - 20070092493 - Living cell sheet A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The coated hydrogel system is reusable and can be used for culturing a multi-layer cell sheet. The obtained living cell sheets may be used for tissue reconstructions. ... 04/26/07 - 20070092492 - Three-dimentional tissue structure The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing ... 04/19/07 - 20070086987 - Skeletal musle-derived cells and methods related thereto The disclosure provides methods of propagating skeletal muscle cell (SkMC) cultures enriched in differentiation-competent myoblasts that express normal levels of CD56 and reduced levels of desmin. The methods comprise culturing SkMCs in a mitogen-rich cell culture medium supplemented with TGF-β. The disclosure also provides therapeutic methods utilizing SkMCs propagated in ... 04/19/07 - 20070086986 - Preparation of three-dimensional mammalian ovarian follicular cell and ovarin follicle culture systems in a biocompatible matrix A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro, and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules ... 04/12/07 - 20070081980 - Culture cells from pancreatic islets A cell composition of endocrine progenitor cells derived from mammalian pancreatic islet cells that can be trans-planted planted into a diabetic patient such t the cells of the cell composition differentiates into functioning insulin-producing beta cells. ... 04/12/07 - 20070081979 - Multi-functional chimeric hematopoietic receptor agonists Disclosed are novel multi-functional chimeric hematopoietic receptor agonist proteins, DNAs which encode the multi-functional chimeric hematopoietic receptor agonist proteins, methods of making the multi-functional chimeric hematopoietic receptor agonist proteins and methods of using the multi-functional chimeric hematopoietic receptor agonist proteins. ... 04/05/07 - 20070077237 - Method for freezing, thawing and transplantation of viable cartilage Disclosed is a method for providing a patient having impaired cartilage in an organ at a target site, with corresponding viable cartilage, possibly osteochondral cartilage. The method comprises freezing the cartilage by cooling it at a cooling rate of 0.01° C./min to 3° C./min. Thawing of the cartilage may be ... 04/05/07 - 20070077236 - Method for cell implantation An endoscopic method for treating cartilage or bone defects in an animal, said method comprising the steps of: I) identifying the position of the defect, ii) applying cells selected from the group consisting of chondrocytes, chondroblasts, osteocytes and osteoblasts and combinations thereof into the cartilage or bone defect. In particular, ... 03/29/07 - 20070071733 - Synthetic substrate for tissue formation The invention relates to a substrate on which to grow synthetic cartilage, a method for preparing the substrate, a synthetic cartilage patch comprising the substrate, and methods of using the synthetic cartilage patch. ... 03/29/07 - 20070071732 - Secretory cell-containing macrobeads comprising seakem gold agarose, and uses thereof The invention describes the manufacture and use of secretory cell containing bead structures that are coated with agarose. The beads, which are preferably 4 mm-12 mm in diameter, and which preferably contain islets, are made of a particular agarose, i.e., Seakem Gold agarose. ... 03/29/07 - 20070071731 - Promotion of neurogenesis of endogenous and transplanted human neural stem cells Disclosed herein are methods and materials for promoting neurogenesis of endogenous and transplanted stem cells. Specifically exemplified herein are methods that comprise transplanting neural stem cells in conjunction with a regimen of (+)phenserine treatment. ... 03/29/07 - 20070071730 - Stem cells of the islets of langerhans and their use in treating diabetes mellitus Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker ... 03/29/07 - 20070071729 - Dermal fillers for biomedical applications in mammals and methods of using the same A method of tissue augmentation in mammals comprising implanting or injecting into the tissue of a mammal elastic material derived from solar elastosis or other sun-damaged sites in humans is disclosed. The method further comprises injecting into the tissue of a mammal, alone, or in combination with the solar elastosis, ... 03/29/07 - 20070071728 - Biomimetic nanocomposite A biomimetic nanocomposite including hydroxyapatite nanocrystals, gelatin, and polymer, wherein the biomimetic nanocomposite is crosslinked is described. Also described is a process for making the nanocomposite. Additionally, a method for using the nanocomposite, and articles formed from the nanocomposite are also described. ... 03/29/07 - 20070071727 - Melanocytes in therapy of neurodegenerative diseases In vitro cultivation method for producing human melanocytes which are capable of melanin and/or L-dopa synthesis, and to various uses of said melanocyte(s). In one preferred aspect, said melanocyte(s) are used in an autologous implantation method in a patient suffering from a neurodegenerative disease, e.g. Parkinson's disease. In another aspect, ... 03/22/07 - 20070065420 - Ultrasound therapy resulting in bone marrow rejuvenation A method and system for treating a patient to repair damaged tissue which includes exposing a selected area of bone marrow of a patient to ultrasound waves or ultra shock waves so that cells comprising stem cells, progenitor cells or macrophages are generated in the area of the bone marrow ... 03/22/07 - 20070065419 - Keratinocytes useful for the treatment of wounds The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds. ... 03/22/07 - 20070065418 - Method and device for cellular therapy A device and method for performing a therapeutic treatment at a treatment site in a patient's vessel, the device configured to be introduced by means of a catheter, the device including an expandable portion capable of being expanded between a contracted position and a deployed position at the treatment site, ... 03/22/07 - 20070065417 - Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying ... 03/22/07 - 20070065416 - Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying ... 03/22/07 - 20070065415 - Compositions and methods for the augmentation and repair of defects in tissue Compositions and methods of treating a defect in a patient are disclosed, including expanding a culture of autologous cells in vitro to form cultured cells, collecting the cultured cells for introduction into the patient, and depositing the cultured cells with ancillary proteins. ... 03/22/07 - 20070065414 - Enhanced delivery of cells The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or ... 03/15/07 - 20070059293 - Tissue engineered construct for supplementing or replacing a damaged organ The present invention provides methods and compositions for supplementing or replacing a damaged organ. The damaged organ to be supplemented or replaced in accordance with the present invention include, for example, kidney, heart, liver, spleen, pancreas, bladder, ureter and urethra. In one embodiment, the tissue-engineered construct of the invention has ... 03/08/07 - 20070053888 - Use of umbilical cord blood to treat individuals having a disease, disorder or condition The present invention provides methods of using cord blood and cord blood-derived stem cells in high doses to treat various conditions, diseases and disorders. The high-dose cord blood and cord blood-derived stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and ... 03/08/07 - 20070053887 - Method for production of neuroblasts A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts. ... 03/08/07 - 20070053886 - Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between ... 03/08/07 - 20070053885 - Mesenchymal stem cell It is intended to obtain a mesenchymal stem cell in the early stage of differentiation from a pluripotent stem cell differentiated in vitro. A mesenchymal stem cell is obtainable by: a) the step of culturing pluripotent stem cells, b) the step of confirming the appearance of a cell with stroma ... 03/08/07 - 20070053884 - Novel adult tissue-derived stem cell and use thereof Subjects of the present invention are to establish a technology for separating, isolating and culturing a stem cell derived from adult tissue while retaining the in vivo properties thereof, and to provide a preventive and/or therapeutic agent for diseases which accompany tissue injury, which comprises a stem cell derived from ... 03/08/07 - 20070053883 - Neuronal cell lineages and methods of production thereof Methods are provided in which a sterol-depleting agent such as β-cyclodextrin (βCD), is used to modulate signaling by a differentiation signaling protein such as Hedgehog protein or a BMP in vitro. As illustrated herein, the use of βCD in conjunction with Sonic Hedgehog N-terminal peptide (ShhN) causes substantially all of ... 03/01/07 - 20070048292 - Cell-containing sheet In accordance with the present invention, an implant in which cells are arranged in a fine pattern that is available for immediate implantation and that does not need to be removed after implantation is provided. The present invention relates to a cell-containing sheet, which comprises cells and a support comprising ... 03/01/07 - 20070048291 - Method and material for enhanced tissue-biomaterial integration The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and ... 03/01/07 - 20070048290 - Development of natural killer cells and functional natural killer cell lines The invention relates to natural killer cells and methods for the development of immortalized natural killer cells and use of the natural killer cells. A growth and culture system is described that supports increased natural killer cell development, and provides for the establishment of continuous natural killer cell lines. Additionally, ... 03/01/07 - 20070048289 - Cellular intervention to treat damaged myocardium A system and method for treating damage myocardial tissue includes delivering replacement cells to the myocardium of a patient and electrically stimulating the spinal column of the patient to affect a cellular environment within the myocardium. ... 03/01/07 - 20070048288 - Shear thinning polymer cell delivery compositions Cell delivery compositions including shear thinning polymers and their use in cell delivery are described. The cell delivery compositions include shear thinning polymers that confer higher viscosity when at rest and decreased viscosity when subject to shear stress when dissolved or suspended in a carrier liquid. These shear thinning properties ... 02/22/07 - 20070041956 - Vaccine immunotherapy for immune suppressed patients A method for overcoming mild to moderate immune suppression includes the steps of inducing production of naïve T-cells and restoring T-cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naïve T-cells and exposing the naïve T-cells to endogenous or exogenous antigens at an appropriate site. ... 02/22/07 - 20070041955 - Hedgehog signaling promotes the formation of three dimensional cartilage matrices The present invention provides methods and compositions for promoting the formation of three dimensional cartilage matrices. The present invention further provides methods of treating diseases and injuries involving cartilage and bone using the three dimensional cartilage matrices provided herein. ... 02/22/07 - 20070041954 - Compositions of placentally-derived stem cells for the treatment of cancer Disclosed are preparations of placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the ... 02/22/07 - 20070041953 - Smooth muscle progenitor cells Purified populations of smooth muscle progenitor cells are provided as well as methods of making and using the cells. ... 02/22/07 - 20070041952 - Three-dimensional fiber scaffolds for tissue engineering A tissue restoration implant adapted for use with a pre-determined tissue, and methods of making and using the same. The tissue restoration implant adapted for use with a pre-determined tissue can include a three-dimensional fiber scaffold, the scaffold comprising at least three systems of fibers; wherein two of the three ... 02/22/07 - 20070041951 - Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present ... 02/22/07 - 20070041950 - Method and device for selective addition of a bioactive agent to a multi-phase implant A method and device for assembling a multi-phase implant for insertion into a patient defect site that spans more than one tissue type. The assembly device comprises a base and cover portion for constructing a two-phase implant separated by a membrane. A repeating intermediate portion that connects the base and ... 02/22/07 - 20070041949 - Ultrasonic modification of soft tissue matrices The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices ... 02/22/07 - 20070041948 - Method for culturing and proliferating hematopoietic stem cells and progenitor cells using human endometrial cells Disclosed herein is a method for culturing and proliferating hematopoietic stem cells or progenitor cells. The method comprises co-culturing the hematopoietic stem cells or the progenitor cells with human endometrial stromal cells so as to promote the expansion of hematopoietic stem cell-derived CD34+ cells or the growth of the progenitor ... 02/15/07 - 20070036768 - Systems and methods for treating patients with processed lipoaspirate cells Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are ... 02/15/07 - 20070036767 - Postpartum cells derived from umbilical cord tissue, and methods of making and using the same Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described. ... 02/15/07 - 20070036766 - Tissue graft composition comprising autologous bone marrow and purified autologous thrombin A method for the preparation of an autologous tissue graft composition is disclosed. Bone marrow is harvested from the patient. In one embodiment, the nucleated cells of the bone marrow are subsequently concentrated. Autologous thrombin is purified from a volume of whole blood also taken from the patient. The bone ... 02/15/07 - 20070036765 - Therapeutic and diagnostic applications of genes differentially expressed in lympho-hematopoietic stem cells The invention is based at least in part on the discovery of novel group of genes and/or their encoded gene products that are differentially represented in two substantially enriched CD34+/CD38−/Lin− and CD34+/[CD38/Lin]++ hematopoietic cell populations isolated from normal human bone marrow, cord blood, and peripheral blood stem cell preparations. ... 02/08/07 - 20070031389 - Transplants for myocardial scars A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart. ... 02/08/07 - 20070031388 - Cell-charged multi-layer collagen membrane A multi-layer sheet of collagen membrane material includes a barrier layer including an outer smooth barrier face and further including a fibrous face opposite the smooth barrier face, and a matrix layer of collagen material adhered to the fibrous face, the matrix layer including collagen I, collagen III, or a ... 02/08/07 - 20070031387 - Method for treating and/or preventing spinal cord injury A method of preventing or treating neurologic function deficit of vertebrates undergone spinal cord injury, comprising administering an effective amount of BM-MNCs to a vertebrate in need thereof through cerebrospinal fluid. ... 02/08/07 - 20070031386 - Modalities for the treatment of degenerative diseases of the retina This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. ... 02/08/07 - 20070031385 - Apparatus and method to treat a wound area A method is disclosed to treat a patient having a wound area, such as a burn injury. The method provides a plurality of epidermal/dermal cells, and applies that plurality of epidermal/dermal cells to the wound area. ... 02/08/07 - 20070031384 - Regeneration of pancreatic islets by amniotic fluid stem cell therapy A method of treating diabetes in a mammalian subject is carried out by: (a) providing mammalian amniotic fluid stem cells, and then (b) administering the cells to the subject in an amount effective to treat diabetes. Optionally, the cells may be differentiated into pancreatic-like cells or at least treated to ... 02/01/07 - 20070025973 - Reprogramming of adult or neonic stem cells and methods of use The present invention relates to methods of reprogramming adult stem cells or stem cells obtained from umbilical or placental cord blood or more preferably, the placeta or umbilical cord tissue itself or the amniotic fluid or amnion. The resulting stem cells and methods of using these stem cells represent additional ... 02/01/07 - 20070025972 - Methods and compositions for smooth muscle reconstruction This invention also provides a purified or isolated population of ADSCs that can differentiate into a cell of the leiomyogenic lineage, e.g., smooth muscle or skeletal muscle. In yet another aspect, the population additionally can be differentiated into a lineage selected from the group consisting of osteogenic, adipogenic, chondrogenic, myogenic ... 01/25/07 - 20070020247 - Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs ... 01/25/07 - 20070020246 - Use of microchimeric cells in the treatment of malignancy Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy approaches to hematologic malignancies that are expected to be well tolerated immunologically. Studies will confirm that parous females who display MC are ... 01/25/07 - 20070020245 - Composition for the treatment of arthrosis/arthritis, especially for treating joints The invention especially relates to a composition for the treatment of arthrosis/arthritis, especially for treating joints, said composition containing at least one carrier substance for receiving at least one anti-inflammatory agent and chondrogenetic cells, in addition to at least one anti-inflammatory agent, and chondrogenetic cells. ... 01/25/07 - 20070020244 - Fiber constructs and process of fiber fabrication Described herein are fiber compositions, methods of generating the fiber compositions, and methods of using the fiber compositions in various applications utilizing fiber constructs, including for example, tissue engineering. ... 01/25/07 - 20070020243 - Methods and compositions related to modulating the extracellular stem cell environment This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell ... 01/25/07 - 20070020242 - Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway The subject invention relates to a method of transdifferentiating mammalian non-pancreatic stem cells, such a mesenchymal stem cells (MSCs), to enter the pancreatic differentiation pathway. The MSCs are cultured under conditions that permit the expression of pancreatic differentiation markers, and these conditions include use of: (a) culture conditions that promote ... 01/18/07 - 20070014772 - Engineered biografts for repair of damaged myocardium A method for repairing a damaged myocardium in a mammal, comprising: a) providing a three-dimensional porous polysaccharide matrix; b) introducing mammalian cells into said matrix; c) growing said cells in said matrix in vitro, until a tissue-engineered biograft is formed, comprising a contracting tissue; and d) transplanting the tissue-engineered biograft ... 01/18/07 - 20070014771 - Postpartum cells derived from umbilical cord tissue, and methods of making and using the same Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described. ... 01/11/07 - 20070009495 - Method for treating or preventing systemic inflammation in formula-fed infants The present invention is directed to a novel method for treating or preventing systemic inflammation in a formula-fed infant. The method administering to the infant a therapeutically effective amount of LGG in combination with at least one LCPUFA. ... 01/11/07 - 20070009494 - Postpartum cells derived from umbilical cord tissue, and methods of making and using the same Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described. ... 01/11/07 - 20070009493 - Chondrogenic compositions and methods of use The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of cells enhanced with at least one bioactive factor capable of causing at least a portion of the plurality of cells to express ... 01/11/07 - 20070009492 - Multipotent postnatal stem cells from human periodontal ligament and uses thereof The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation. ... 01/11/07 - 20070009491 - Platelet-derived growth factor-responsive neural precursor cells and progeny thereof This invention provides platelet-derived growth factor-responsive neural precursor (PRP) cells and methods of producing such cells in vivo or in vitro. These cells can further be used to generate neurons, oligodendrocytes and/or astrocytes. ... 01/04/07 - 20070003528 - Intracoronary device and method of use thereof Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. ... 01/04/07 - 20070003527 - Method for enhancing leukocyte immune function The present invention provides a method for enhancing the immune function of leukocytes in a subject, which comprises the steps of: (a) isolating leukocytes from the subject; (b) treating the leukocytes obtained from step (a) with an inhibitor of the endoplasmic reticulum calcium ion pump; and (c) administrating the treated ... 01/04/07 - 20070003526 - Blood vessel-specific organogenesis from embryonic stem cells on three-dimensional matrigel layer The present invention provides use of embryonic stem cells or embryonic stem cell-derived embryoid bodies cultured on growth factor-reduced Matrigel™, for treating diseases caused by ischemia or arteriosclerosis. ... 01/04/07 - 20070003525 - Hydrogel compositions comprising nucleus pulposus tissue Disclosed are methods and compositions useful in the treatment, augmentation and/or repair of soft and/or hard tissues of animals, and in particular, vertebrates such as humans. The invention provides hydrogel compositions for use in the preparation of medicaments for wound healing, cartilage and meniscus repair, dermal augmentation, and bone fusion, ... 12/28/06 - 20060292128 - Methods of treating schizophrenia The invention provides methods for the treatment of abnormal psychiatric states, particularly the negative symptoms of schizophrenia and extrapyramidal side effects (EPS) of antipsychotic drugs. The inventive methods relate to the administration of therapeutic cells (which produce dopamine or dopamine precursors) adhered to support matrices to subjects suffering from the ... 12/28/06 - 20060292127 - Beta cell growth and differentiation The invention includes methods that can be used to increase β cell populations in vivo and in vitro, useful in the treatment of diabetes and related disorders. ... 12/28/06 - 20060292126 - Epidermal and dermal equivalents The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for primary, as well as subsequent organotypic cultures (i.e., epidermal equivalents) in fully-defined media supplemented by autologous human serum and substances isolated form blood ... 12/28/06 - 20060292125 - Methods for treating ischemic tissue Compositions and methods for treating ischemic tissue are provided herein. ... 12/21/06 - 20060286079 - Use of cytokines and mitogens to inhibit pathological immune responses The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders. ... 12/21/06 - 20060286078 - Methods of treating cardiorenal syndrome and hepatorenal syndrome A method of treating a patient with cardiorenal syndrome and hepatorenal syndrome are provided in which a portion of the body fluid of the patient is exposed to renal epithelial cells, outside of the kidney of the patient, whereby the body fluid is in fluid communication with renal epithelial cells ... 12/21/06 - 20060286077 - Perivascular mesenchymal precursor cell induced blood vessel formation Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 ... 12/14/06 - 20060280727 - Dendritic cell isolation methods Disclosed are methods for isolating dendritic cells and/or dendritic progenitor cells. The methods include contacting a population of cells with a plurality of FRIL family member molecules, and removing the unbound cells, wherein the cells bound to the FRIL family member molecules are an isolated population of dendritic cells and/or ... 12/14/06 - 20060280726 - Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying ... 12/07/06 - 20060275273 - Intervertebral disc repair, methods and devices therefor The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise ... 12/07/06 - 20060275272 - Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases The present invention relates to a treatment of an autoimmune demyelinating disease/disorder. Also included in the present invention is the use of bone marrow stromal cells for the treatment of multiple sclerosis (MS). ... 12/07/06 - 20060275271 - Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma ... 12/07/06 - 20060275270 - In vitro mucosal tissue equivalent The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with pathogens and vaccines in mammals. The artificial immune system can be used to test the efficacy of ... 12/07/06 - 20060275269 - Method and data system for the treatment at birth of a patient who is identified at birth as having an elevated risk of a previously unidentified disorder The present invention provides a procedure used in the overall treatment of a patient who is identified at birth as having an elevated risk of a previously unidentified disorder and method of using a data system to assist in the procedure. In a preferred embodiment, the procedure involves, at the ... 12/07/06 - 20060275268 - Compositions for activating the infiltration activity of dendritic cells, and immunopotentiating agents The present invention's compositions for activating the infiltration activity of dendritic cells comprise retinoid. Retinoid increases the production of MMP-9, which is required for dendritic cells to exert their infiltration activity, and thereby activates the dendritic cells' infiltration activity. Therefore, the compositions exhibit immunopotentiating effects and can be used in ... 11/30/06 - 20060269527 - Isolation of cells from bone The present invention provides a method for isolating cells from bone(s) harvested from a mammal. The method comprising the steps of: (a) obtaining a bone(s) containing bone marrow from the mammal; (b) fragmentation of the bone(s); (c) washing the bone fragments produced from step (b) and recovery of dislodged cells; ... 11/30/06 - 20060269526 - Stromal antigen-presenting cells and use thereof There is provided a stromal antigen-presenting cell capable of antigen presentation in the context of MHC II. When stimulated with IFNγ the stromal cell expresses B7-H1 and/or CD80. These stromal cells can be used to generate an immune response in an animal. ... 11/30/06 - 20060269525 - Co-grafts for treating parkinson's disease This invention relates to a graft for treating Parkinson's Disease, wherein, in one embodiment, the graft contains an effective amount of both a) adrenal chromaffin cells (ACCs), and b) olfactory ensheathing cells (OECs), and GDF-5. ... 11/30/06 - 20060269524 - Composition for nkt cell activation R2 represents hydrogen, or α-galactose, α-glucose, α-mannose, α-glucosamine, β-glucosamine or a combination thereof. ... 11/23/06 - 20060263341 - Selected cell delivery for heart failure This invention provides methods of increasing blood flow to tissue in a subject in need thereof, methods of regenerating tissue in a subject, methods of treating diseased tissue in a subject, methods of forming new blood vessels in tissue and new tissue, such as myocardial tissue, in a subject in ... 11/23/06 - 20060263340 - Treating gastrointestinal diseases with modulators of retinoic acid T cells are programmed to target the gastrointestinal tract by activation with dendritic cells capable of producing and/or transporting retinoic acid. Methods for using the programmed dendritic cells and/or T and/or B cells to treat a variety of pathogens and infectious agents residing in the intestine are also disclosed. Similarly, ... 11/23/06 - 20060263339 - Recovery of tissue function following administration of b cells to injured tissue The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells ... 11/23/06 - 20060263338 - Catheter-based delivery of skeletal myoblasts to the myocardium of damaged hearts The present invention provides improved systems and methods for the minimally invasive treatment of heart tissue deficiency, damage and/or loss, especially in patients suffering from disorders characterized by insufficient cardiac function, such as congestive heart failure or myocardial infarction. In certain embodiments, a cell composition comprising autologous skeletal myoblasts and, ... 11/23/06 - 20060263337 - Immunomodulatory properties of multipotent adult progenitor cells and uses thereof Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. ... 11/23/06 - 20060263336 - Cell targeting methods and compositions In certain aspects, the invention relates to cell delivery compositions comprising a progenitor cell and a targeting moiety, and methods related thereto. Such compositions and methods may be used, for example, in administering a targeted cell therapy to a subject. ... 11/23/06 - 20060263335 - Porous matrix A porous matrix suitable for use as a tissue scaffold is described. The matrix may be shaped before insertion into or at the target tissue site, or injected via a minimally invasive method. The matrix may be pre-seeded with cells of the target tissue or may be used to support ... 11/16/06 - 20060257379 - Surgical system for the preparation of an implant and method for the preparation of an implant In order to improve a surgical system for the preparation of an implant for filling a defect on a bone and/or a cartilage of a human or animal body formed as a result of a trauma and/or degeneration, so that the defect can be filled with the implant with as ... 11/16/06 - 20060257378 - Adaptive sol-gel immobilization agents for cell delivery The present invention relates to formulations which form hydrogels at physiological temperatures. More specifically, the present invention relations to formulations having a prepolymer, an additive, and a temperature protectant, wherein the prepolymer and additive polymerize at physiological conditions to form a hydrogel. The formulations can further comprise cell suspensions such ... 11/16/06 - 20060257377 - Production of tissue engineered digits and limbs The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite ... 11/16/06 - 20060257376 - Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem ... 11/09/06 - 20060251629 - Muscle-based grafts/implants The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for ... 11/09/06 - 20060251628 - Defatted, dewatered bone marrow Bone marrow aspirate from which water and fat have been substantially removed. ... 11/02/06 - 20060246042 - Cells, culture methods, and their use in autologous transplantation therapy The present invention provides use of a host cell population obtained from a non-diseased host organism for the preparation of a cell-composition for use in subsequent autologous transplantation therapy of said host organism. ... 11/02/06 - 20060246041 - Methods and reagents for tissue engineering of cartilage in vitro The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient. ... 10/26/06 - 20060239983 - Methods and compositions for the repair and/or regeneration of damaged myocardium Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and ... 10/26/06 - 20060239982 - Debulking catheters and methods A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking ... 10/26/06 - 20060239981 - Bioreactor system and method of enhancing functionality of muscle cultured in vitro A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) ... 10/26/06 - 20060239980 - Cartilage-derived stem cells and applications thereof The invention relates to methods of isolating adult stem cells, to the cells thus isolated and to applications thereof. More specifically, the invention relates to isolated adult stem cells, which are derived from dedifferentiated chondrocytes, which can be differentiated and which can give rise to a series of cell lineages, ... 10/26/06 - 20060239979 - Dendritic cell presenting a-glycosylceramide derivative and antigent and usable in suppressing immune response The present invention relates to dendritic cell and cell mixture which is capable of suppressing T cell-dependent immune response specific for an antigen. The dendritic cell according to the present invention is a dendritic cell capable of suppressing T cell-dependent immune response specific for an antigen, which presents antigen fragment ... 10/26/06 - 20060239978 - Gene expressed specifically in dopamine-producing neuron precursor cells after termination of division A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network ... 10/19/06 - 20060233769 - Established cell line of microglia A subcultivatable, established microglia having the following properties. (a) Form: Both or either of a macrophage-like or spherical form in the presence of a granulocyte-macrophage colony stimulation factor and a branched form similar to branched microglia present in the brain in the absence of the factor. (b) Functional characteristics: specific ... 10/19/06 - 20060233768 - Elective collection and banking of autologous peripheral blood stem cells An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or “pre-disease” state, for future distribution for his ... 10/19/06 - 20060233767 - Process for producing a tissue transplant construct for reconstructing a human or animal organ A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue ... 10/19/06 - 20060233766 - Treatment of parkinson's disease and related disorders using postpartum derived cells Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided. ... 10/19/06 - 20060233765 - Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed. ... 10/19/06 - 20060233764 - Skin regeneration system A cell culture medium and system are provided which eliminate or at least reduce the requirement for exogenous components such as serum and feeder cells. The cell culture medium comprises an IGF and vitronectin or fibronectin and, optionally an IGFBP, and is particularly suitable for propagating keratinocytes for subsequent use ... 10/19/06 - 20060233763 - Cartilaginous cell culture medium and the use thereof A cartilage cell culture medium comprising a basic medium suitable for culturing primary human cells and, said culture medium additionally containing 0.5 to 50.0 ng/ml of EGF, 0.5 to 50.0 ng/ml of FGF, 0.1 to 10.0 ng/ml of PDGF, 0.5 to 50.0 ng/ml of IGF, 1.0 to 100.0 ng/ml of ... 10/12/06 - 20060228341 - Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. ... 10/12/06 - 20060228340 - Hematopoietic stem cells treated by in vitro fucosylation and methods of use A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an α1,3-fucosyltransferase, e.g., α1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derived hematopoietic stem cells to convert non-functional PSGL-1 or other ... 10/12/06 - 20060228339 - Methods of preparing transplantable product for treatment of skin defects A method for preparing a tissue culture insert that is used for constructing a transplantable graft of an engineered tissue equivalent comprising living main functional cells, stromal cells and tissue matrix on/in a biological supporting membrane for treatment of body tissue defects. ... 10/12/06 - 20060228338 - Isolated/cloned human nt2 cell lines expressing serotonin and gaba Human cells isolated and/or cloned from human NT2 cells for expressing serotonin (5HT) and gamma-aminobutyric acid (GABA) are disclosed. These cells can be used as cellular minipumps to release serotonin and/or GABA to treat various neurological diseases, conditions, or disorders, particularly neurodegenerative disorders and the consequences of brain and spinal ... 10/05/06 - 20060222634 - Amnion-derived cell compositions, methods of making and uses thereof The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived ... 10/05/06 - 20060222633 - Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host The invention includes compositions and methods for depleting and/or inactivating antigen presenting cells, or for otherwise impairing the biological function of antigen presenting cells, which compositions are useful for treatment of graft versus host disease and other immune diseases. ... 09/28/06 - 20060216276 - Use of materials for treatment of central nervous system lesions Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells. ... 09/21/06 - 20060210543 - Method of treating infarcted myocardium A method of treating an infarcted myocardium, the method comprising administering to the myocardium of a subject in need thereof a therapeutically effective amount of osmotically activated immune cells, thereby treating the infarcted myocardium. ... 09/21/06 - 20060210542 - Use of tpo mimetic compounds and pharmaceutical compositions in the treatment of anemia A method of treating anemia is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier as well as diagnostic methods employing a labeled TPO mimetic compound are also disclosed. ... 09/14/06 - 20060204483 - Cellular telomerase vaccine and its use for treating cancer The invention provides dendritic cell (DC) preparations that present a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DCs may be pulsed with a TRT polypeptide, or may comprise a recombinant polynucleotide encoding TRT. The invention also describes the ... 09/14/06 - 20060204482 - Methods of islet isolation and transplantation The present invention relates to methods for improving the viability and recovery of islets that are separated from a donor organ for subsequent transplantation. In a preferred embodiment, the islets are separated from a donor pancreas and transplanted into the liver of a diabetic patient. One or more emulsified perfluorocarbons ... 09/14/06 - 20060204481 - Methods of promoting cell viability Methods for promoting viability of a transplant cell population by administering a hydrophilic bile acid, such as ursodeoxycholic acid (UDCA), salts thereof, and analogs thereof (e.g., glycoursodeoxycholic acid and tauroursodeoxycholic acid). ... 09/07/06 - 20060198827 - Engineering vascularized muscle tissue A tissue engineered construct. The construct includes endothelial cells, muscle cells, and a three-dimensional support matrix on which the endothelial cells and the myoblasts are seeded. ... 08/31/06 - 20060193839 - Method of providing readily available cellular material derived from peripheral blood, and a composition thereof The present invention is directed to the TVEMF-expansion of mammalian peripheral blood stem cells, preferably CD34+/CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions. ... 08/31/06 - 20060193838 - Method and composition for treating diabetes The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+/CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions. ... 08/31/06 - 20060193837 - Method and composition for repairing epithelial and other cells and tissue The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+/CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating a disease or condition or repairing tissue of skin, mouth or ear with the compositions. ... 08/31/06 - 20060193836 - Method and composition for repairing heart tissue The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+/CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating heart disease or repairing heart tissue with the compositions. ... 08/31/06 - 20060193835 - Treatment of congestive heart failure A method of treating congestive heart failure (CHF) in a human patient comprises treating an aliquot of the patient's blood ex vivo with at least one stressor selected from the group consisting of a temperature above or below body temperature, an electromagnetic emission and an oxidative environment, followed by administering ... 08/24/06 - 20060188488 - Prevascularized constructs for implantation to provide blood perfusion This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream. ... 08/24/06 - 20060188487 - Blend hydrogels and methods of making The present invention provides blend water-swellable materials and hydrogels suitable for use in biomedical or other applications. The blend water swellable materials and hydrogels have at least one hydrophilic polymer and at least one other polymer or oligomer having both hydrophobic and hydrophilic recurring units where the blend phase separates ... 08/24/06 - 20060188486 - Wound care polymer compositions and methods for use thereof The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of ... 08/24/06 - 20060188485 - Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations The invention relates to cells of monocytic origin suitable for the prevention and/or treatment of diseases associated with disturbed self-tolerance, in particular autoimmune diseases and allergies, and to pharmaceutical preparations containing these cells. The cells are autologous in relation to the patient to whom they are to be administered. The ... 08/17/06 - 20060182725 - Treatment of tissue with undifferentiated mesenchymal cells The present invention provides compositions and methods for correcting cosmetic, aesthetic, and degenerative defects in the skin, soft tissue, and bone of a subject. In particular, methods of the invention involve the injection or implantation of autologous UMC, fibroblasts, and/or keratinocytes into the tissue (e.g., subcutaneous tissue) adjacent or subadjacent ... 08/17/06 - 20060182724 - Method for expansion of stem cells A method of increasing the growth of stem cells by mixing the stem cells with a growth medium that has been conditioned by an incubation with placental tissue. The method increases the expansion of the stem cell population. ... 08/17/06 - 20060182723 - Methods for treating refractory infections in neutropenic individuals The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic compositions and methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by ... 08/17/06 - 20060182722 - Methods and materials for isolating isogenic islet cells Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients. ... 08/17/06 - 20060182721 - Method of preparing langerhans cell from cd14-positive cell being human peripheral blood mononuclear cell with use of notch ligand delta-1, gm-csf and tgf-ss This invention provides a method for preparing Langerhans cells from CD14-positive cells, which are human peripheral blood mononuclear cells. This method comprises culturing human peripheral blood mononuclear cells in the presence of Notch ligand, GM-CSF, and TGF-β. ... 08/17/06 - 20060182720 - Cell preparation and use of the preparation for treating joints and cartilage defects, and methods for the production thereof The invention relates to a cell preparation for therapeutic and/or cosmetic use in humans and/or animals, containing: a) human or animal cells, which; b) had been cultured while using a substance or substance mixtures that activates) CD44 expression of these cells, and which present an increased CD44 expression of these ... 08/10/06 - 20060177427 - Dna coding for endo-beta-galactosidase A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of Clostridium perfringens as a template to thereby obtain a fragment of cDNA encoding endo-β-galactosidase, effecting cassette PCR by using the ... 08/10/06 - 20060177426 - Method of preserving lyophilized microorganisms for transport, storage and recovery of viable microorganisms Incorporation of a microbial cell suspension throughout a fibrous network provides a physical environment that allows greater removal of water during lyophilization or desiccation thereby yielding a device with improved stability and recovery of viable microbial cells. Strands of appropriate fibers in a tightly knit network absorb aqueous cell suspensions ... 08/03/06 - 20060171932 - Adipose derived stromal cells exhibiting characteristics of endothelial cells The present invention encompasses an adipose-derived adult stromal (ADAS) cell exhibiting at least one characteristic of a pre-endothelial cell and/or an endothelial cell. The present invention also encompasses compositions and methods for generating an adipose-derived adult stromal to exhibit at least one characteristic of a pre-endothelial cell and/or an endothelial ... 08/03/06 - 20060171931 - Methods and compositions for modulating stem cell growth and differentiation Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit ... 08/03/06 - 20060171930 - Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described. ... 08/03/06 - 20060171929 - Regulation of dendritic cell functions by the dcal-2 receptor This invention provides antibodies that specifically bind to DCAL-2 and other DCAL-2 reagents that modulate dendritic cell function. Modulators of the receptor, including modulators that alter DCAL-2 associated signals to and from DCs, can be used to alter dendritic cell function and to enhance or inhibit immune responses to cancer ... 08/03/06 - 20060171928 - Monocyte-origin multipotent cell momc The present invention is to provide a multipotent cell wherein the sufficient amount necessary can be stably and conveniently supplied with a minimum invasion, that will not cause rejection at the time of cell transplantation, that has a potential to differentiate into various cells such as mesenchymal cells including bone, ... 07/27/06 - 20060165663 - Scaffold material for regeneration of hard tissue/soft tissue interface This invention relates to a scaffold consisting of a biodegradable polymeric material with a composition gradient of calcium phosphate that is capable of effectively regenerating the hard/soft tissue interface and an implant for hard/soft tissue filling with the utilization of such scaffold. ... 07/27/06 - 20060165662 - Isolation of target cells, capillaries and microorgans An isolation method for target cells, capillaries and microorgans comprises perfusion of an organism with a solution containing magnetic beads, removal of a selected tissue or region of the organism, digestion of the portion removed and isolation of the target cells, capillaries or microorgans using a magnet. Filtration may be ... 07/20/06 - 20060159668 - Resorbable extracellular matrix for reconstruction of bone A bone healing combination material includes a matrix carrying cultivated bone-forming cells which may be osteocytes, osteoblasts, stromal stem cells or stem cells committed to differentiation into bone-forming osteoblasts. The matrix is a purified collagen matrix material derived from natural collagen-containing animal tissue, a collagen-free porous bone mineral matrix material ... 07/20/06 - 20060159667 - Rapamycin-resistant t cells and therapeutic uses thereof Methods for generating highly enriched Th1/Tcl and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also ... 07/20/06 - 20060159666 - Method of potentiating inflammatory and immune modulation for cell and drug therapy A method for repairing animal tissue damage due to an inflammatory reaction in an animal has the steps of providing umbilical cord blood cells (UCBCs) in a pharmaceutically acceptable form; and administering a sufficient dose of UCBC at an optimal time thereby reducing the injury from the inflammatory reaction. Also ... 07/20/06 - 20060159665 - Seed tear resistant scaffold A seeded tear resistant scaffold comprising a biocompatible, tear resistant substrate, a biocompatible biodegradable material and optionally cells. ... 07/20/06 - 20060159664 - Tissue graft scaffold Bioengineered tissue graft scaffolds and method for producing such scaffolds are provided. The scaffolds are useful to replace or repair damaged mammalian tissues and organs. ... 07/20/06 - 20060159663 - Growth factor encapsulation system for enhancing bone formation This invention provides articles of manufacture, compositions of matter and methods related to a growth factor encapsulation system for enhancing bone formation. ... 07/20/06 - 20060159662 - Therapeutic anti-melanoma compounds The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides methods for inducing an immune response and administering immunotherapy to a subject by delivering the ... 07/13/06 - 20060153819 - Bone marrow stromal cells for immunoprotection of transplanted neural stem cells The present invention encompasses methods and compositions for reducing an immune response to a transplant recipient receiving NSCs by treating said recipient with an amount of bone marrow stromal effective to reduce or inhibit host rejection of the NSCs. ... 07/13/06 - 20060153818 - Cartilage and bone repair and regeneration using postpartum-derived cells Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products ... 07/13/06 - 20060153817 - Cartilage and bone repair and regeneration using postpartum-derived cells Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products ... 07/13/06 - 20060153816 - Soft tissue repair and regeneration using postpartum-derived cells and cell products Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such ... 07/13/06 - 20060153815 - Tissue engineering devices for the repair and regeneration of tissue Tissue engineering devices for use in the repair or regeneration of tissue made of support scaffolds and cell sheets. ... 07/13/06 - 20060153814 - Porous, matrix, preparation thereof, and methods of using the same A porous matrix, preparation thereof, and methods of using the same. The porous matrix of calcium alginate is prepared using a plurality of particles containing a multivalent cation, admixing the particles with ionic cross-linked polysaccharides and water to form a mixture, introducing a cross linker to solidify the mixture, dissolving ... 07/13/06 - 20060153813 - Methods of producing differentiated hematopoietic cells for treatment of cytopenia The present invention generally provides methods for producing differentiated hematopoietic cells, including macrophages, platelets, and granulocytes, by adding cytokines to cultured synchronized bone marrow stem cells at specific phases of the cell cycle. The invention further provides differentiated hematopoietic cells produced by the methods of the invention, as well as ... 07/13/06 - 20060153812 - Medium for stem cells to be used in intervertebral disk generation and regeneration of intervertebral disk using stem cells A medium for stem cell in regeneration of intervertebral disc comprising an autologous serum obtained by sterilization and immobilization of serum of an individual having the intervertebral disc to be regenerated, a medium for cell culture and at least one antibiotic and a method for regenerating an intervertebral disc comprising ... 07/06/06 - 20060147433 - Extracellular matrix composite materials, and manufacture and use thereof Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components ... 07/06/06 - 20060147432 - Tolerogenic antigen-presenting cells It has been found that dendritic cells can be prepared which cannot mature. These cells can provide signal 1 to T cells but cannot provide co-stimulatory signal 2. T cells which are stimulated by the permanently immature dendritic cells therefore anergise, so the dendritic cells are tolerogenic rather than immunogenic. ... 07/06/06 - 20060147431 - Methods for the treatment of lysosomal storage disorders Provided herein are methods for the treatment of lysosomal storage disorders characterized by a missing or defective secreted lysosomal enzyme. Such lysosomal storage disorders include, but are not limited to neuronal ceroid lipofuscinoses. The disclosed methods involve the transplantation of human multipotent neural stem cells into the CNS of patients ... 07/06/06 - 20060147430 - Adipose-derived stem cells for tissue regeneration and wound healing Compositions and methods for promoting tissue regeneration, particularly skin regeneration, with adipose-derived stem cells are provided. Additionally methods and compositions for promoting tissue regeneration with adipose-derived stem cell side population cells are provided. The adipose-derived cells are administered in a tissue regenerating effect amount optionally with a bioactive agent. Additionally ... 07/06/06 - 20060147429 - Facilitated cellular reconstitution of organs and tissues One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non-human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or ... 07/06/06 - 20060147428 - Allogeneic and xenogeneic transplantation The invention provides methods for restoring or inducing imnmunocompetence, the methods including the step of introducing donor thymic tissue into the recipient. The invention also provides methods for inducing tolerance in a recipient including introducing donor thymic tissue into the recipient. The invention further provides methods of inducing tolerance including ... 07/06/06 - 20060147427 - Method for immunotherapy of tumors A method for making dendritic cells reactive to an antigen comprises obtaining a sample of dendritic cells and contacting the cells with the antigen and at least one Toll-like receptor stimulant. Dendritic cells activated by this method provide a means for treating tumors and for creating animal models of autoimmune ... 07/06/06 - 20060147426 - Multilineage-inducible cells and uses thereof Described herein are post natal, multilineage inducible cells (MIAMI cells). In some examples, the cells are isolated from non fractionated, adult (males and females 3 to 72 years old) human bone marrow under cell culture conditions, which are believed to resemble an in vivo niche microenvironment in which primitive multipotent ... 07/06/06 - 20060147425 - Use of enteric glia to promote functional nerve connections Methods of promoting functional regeneration of injured nerve fibers are described. The methods involve administering enteric glial cells to an animal with a nerve injury or neurodegenerative disease. The method is also useful in inducing formation of a blood-brain barrier in the nervous system. ... 07/06/06 - 20060147424 - Human bone stem cells A bone stem cell which may be supplied stably and which is free from the problem about the compatibility in transplantation is disclosed. The bone stem cell according to the present invention is separated from human amniotic mesenchymal cell layer. The bone stem cell may be used for osteogenesis in ... 06/29/06 - 20060140919 - Methods for selectively stimulating proliferation of t cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors ... 06/29/06 - 20060140918 - Bioartificial device for propagation of tissue, preparation and uses thereof The present invention relates to a device and corresponding methods for its use, in the propagation of tissue. The device comprises a bioartificial composite comprised of a substrate having at least one surface capable of the reception and growth promoting retention of a cellular preparation, and a first layer of ... 06/29/06 - 20060140917 - Compositions and methods for selective dissolution of nascent intravascular blood clots Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing hemostatic clots, are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell ... 06/29/06 - 20060140916 - Methods and compositions for treating congestive heart failure Compositions and methods for treating congestive heart failure are provided herein. ... 06/29/06 - 20060140915 - Veterinary protocol for cellular regeneration A medicament and corresponding treatment protocol for in-vivo cellular regeneration within a mammal is described. Applications include the treatment of injuries to bone, cartilage, ligaments and tendons in humans and animals. Treatment includes the step of administering one or more therapeutically effective doses of medicament into an injured, living mammal. ... 06/29/06 - 20060140914 - Repairing or replacing tissues or organs In general, this invention provides methods and compositions for stabilizing, repairing, or replacing damaged or diseased tissues or organs by engineering blood vessels in such tissues or organs. In addition, the invention further provides methods and compositions for producing functional microvascular networks useful in tissue engineering. ... 06/29/06 - 20060140913 - Regeneration initiating cells Methods and compositions for treating hyperglycemia and pancreatic damage as well as stimulating the repair or regeneration of islet cells are disclosed. ... 06/29/06 - 20060140912 - Methods for enhancing engraftment of purified hematopoietic stem cells in allogeneic recipients This invention provides a method of achieving a higher rate of allogeneic hematopoietic stem cell engraftment by either (i) matching the major histocompatibility complex class I K locus between donors and recipients or (ii) identifying how class I K on HSC interact with FC (CD8/33Kd receptor complex) works thus allowing ... 06/22/06 - 20060134076 - Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor This invention relates to a three dimensional bioengineered sphincter such as a bioengineered internal anal sphincter (IAS) and three-dimensional physiological models of smooth muscle cells. The invention also related to methods for generating a bioengineered sphincter and smooth muscle rings in culture. In addition, the invention provides for methods of ... 06/22/06 - 20060134075 - Composition and method for improving function of embryonic kidney transplants Methods and compositions are disclosed for use with embryonic metanephric tissue so as to increase the functioning renal mass obtained upon transplantation into a recipient. ... 06/22/06 - 20060134074 - Compositions and methods for promoting hair growth The present disclosure provides compositions and methods for promoting the growth of hair for cosmetic purposes as well as for treating disorders of hair growth. The compositions are conditioned media obtained from a three dimensional tissue that produce a combination of cellular factors effective to induce, promote, or enhance hair ... 06/22/06 - 20060134073 - Compositions and methods for ex vivo preservation of blood vessels for vascular grafts using analogues of camp and cgmp The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts. The present invention also relates to compositions comprising an analogue of cAMP and/or an analogue of cGMP for use in the methods of the invention, which compositions are free of: ... 06/22/06 - 20060134072 - Self-assembling protein matrix prepared from natural extracellular matrices The present invention provides a method for preparing a biomaterial involving extracting Collagen Type I (Col I) protein from small intestine submucosa (SIS) under conditions that preserve the native helical configuration. The extract of the present method contains a substantial amount of the alpha helical form of Col I. Further ... 06/22/06 - 20060134071 - Use of extracellular matrix and electrical therapy The invention provides methods and devices useful for cardiac repair. ... 06/22/06 - 20060134070 - Tissue regeneration A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an ... 06/22/06 - 20060134069 - Erythrocytic cells and method for preserving cells A dehydrated composition is provided that includes freeze-dried erythrocytic cells. Alcohol (e.g., sterol or cholesterol) is at least partially removed from erythrocytic cells including erythrocytic membranes. After removal of at least part of the alcohol, the erythrocytic cells have a low phase transition temperature range, an intermediate phase transition temperature ... 06/15/06 - 20060127375 - Cryopreservation of human red blood cells A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the ... 06/15/06 - 20060127374 - Method for the in vitro production of cartilage-like tissues A method for the in vitro production of cartilage-like tissue is disclosed. Said method comprises the cultivation of chondrogenic cells in presence of bivalent cation dependent constituents of the extracellular matrix (BCDM) and/or human serum wherein an inhibitory activity of cartilage maturation has been selectively removed from said human serum. ... 06/15/06 - 20060127373 - Use of substance p for mobilization of mesenchymal stem cells or proliferation of mesenchymal stem cells and for wound healing or facilitating wound healing The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing. ... 06/15/06 - 20060127372 - Hypoxia-mediated neurogenesis Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells ... 06/15/06 - 20060127371 - Asb transcription repressor proteins and nucleic acids and their application in expansion of stem cells The present invention relates to methods for expansion of stem or progenitor cells. These methods rely on Asb-a polypeptides or nucleic acids to temporarily suppress differentiation of the cells, thus allowing proliferation and self-renewal of the stem or progenitor cells. Abs-a polypeptides and coding sequences define a class of polypeptides ... 06/15/06 - 20060127370 - Composition for culturing multipotent stem cells and utilization of the same The invention aims to proliferate or establish undifferentiated pluripotent stem cells that retain their differentiation potency by culturing pluripotent stem cells in a medium free of a feeder cell, or a serum. The aim is attained by using a culture medium for pluripotent stem cells comprising the known ingredients, which ... 06/15/06 - 20060127369 - Spatially encoded polymer matrix The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially ... 06/15/06 - 20060127368 - Support for tissue regeneration and process for producing the same The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation ... 06/15/06 - 20060127367 - Compositions containing macrophages and uses thereof The invention relates to the use of macrophages for the preparation of a drug for the treatment of a disease or of a lesion involving cellular apoptosis, reduction of the survival of cells and/or destruction of cells. ... 06/15/06 - 20060127366 - Method and device for inducing biological processes by micro-organs A method, extract, and pharmaceutical composition for inducing angiogenesis in a tissue of a mammal, and of a device for the preparation and delivery of micro-organs into a mammal, are provided. ... 06/15/06 - 20060127365 - Method of cell therapy using fused cell hybrids The present invention relates generally to the field of tissue engineering and more particularly to a method for generating tissue suitable for use in tissue replacement and/or tissue rejuvenation therapy and/or as a source of cell-derived therapeutic or diagnostic agents including proteins and hormones. Even more particularly, the present invention ... 06/08/06 - 20060121007 - Combined regulation of neural cell production This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing ... 06/08/06 - 20060121006 - Production of nutritional and therapeutic products from cultured animal cells The present invention describes methods and products involving the use of cultured animal cells as ingredients in nutritional and therapeutic products. Said animal cells are preferably cultured on an industrial scale prior to their incorporation into any of a number of edible, topical, oral, or other products. ... 06/08/06 - 20060121005 - Activation and expansion of cells The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in ... 06/08/06 - 20060121004 - Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin The use of antithrombin to improve the therapeutic efficacy of cell and organ transplantation. ... 06/08/06 - 20060121003 - In situ maturation of dendritic cells A method for eliciting an immune response to an antigen in a subject via (a) loading isolated antigen presenting cells with an antigen ex vivo; and (b) administering the antigen presenting cells to a subject at a pre-treated site. ... 06/08/06 - 20060121002 - Methods and compositions for tissue regeneration The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and stages of differentiation. Also provided are unencapsulated preparations (mixed with or applied to extracellular matrix material or synthetic biocompatible substances) ... 06/08/06 - 20060121001 - Method for preparing animal or human adult stem cells and therapeutic use thereof The invention relates to tissue regeneration and repair by cell transplant. More particularly, the invention concerns a method for preparing adult stem cells which preserves the diversity and plasticity of said cells. The invention also concerns the use of said stem cells obtained by the inventive extraction method for therapeutic ... 06/01/06 - 20060115459 - Sickle cell anemia treatment This patent is an evolution of U.S. Pat. No. 4,216,770 named “sickle cell therapeutic treatment”. That patent is one in which blood is taken out of the subject and treated with anti-sickling agents which are then washed out. In this application blood is removed from a subject and instead filtered ... 06/01/06 - 20060115458 - Material for repairing biological tissues, product for repairing biological tissues, and method of manufacturing material for repairing biological tissues Osteoblast activity is promoted and a large amount of extracellular substrates are produced so as to promote cell proliferation and/or differentiation. A material for repairing biological tissues, the material comprising a biocompatible material containing at least one of niobium and tantalum, is provided. These metal salts are not toxic even ... 06/01/06 - 20060115457 - Biocompatible hydrogel compositions Compositions, instruments, systems, and methods are providing for creating families of materials having diverse therapeutic indications and possessing enhanced biocompatibility. One genus platform for the families includes a biocompatible synthetic electrophilic component mixed with a nucleophilic component. The electrophilic component can include a functionalized electrophilic poly (anhydride ester) material. The ... 05/25/06 - 20060110374 - Method to accelerate stem cell recruitment and homing A method is provided for facilitating treatment of a patient, including stressing a portion of the patient to an extent sufficient to induce homing of progenitor cells to the portion of the patient. A method is additionally provided for use with tissue of a patient, including evaluating an indication of ... 05/25/06 - 20060110373 - Ptu compounds for promoting the in vitro culture of (highly pigmented) melanocytes A method for promoting the in vitro multiplication of human melanocytes and/or the freezing thereof, notably human melanocytes obtained from individuals of phototype IV, V or VI or from hyperpigmentary lesions, entails introducing into a culture of same, a thus effective amount of at least one 1-phenyl-3-(2-thiazolyl)-2-thiourea (PTU) compound or ... 05/25/06 - 20060110372 - Regulatory cells that control t cell immunoreactivity [Solution means] CD8+CD122+ T cell subsets are provided as regulatory T cells that suppress activity of activated CD8+ killer T cells. Administration of these T cell subsets can suppress tissue/cell damages. In addition, it has become possible to explore agents that augment immunosuppressive activity of these T cell subsets by ... 05/25/06 - 20060110371 - Control of indoleamine 2,3 deoxygenase expression and activity The present invention relates to controlling and/or manipulating of dendritic cells by controlling the expression and activity of indoleamine 2,3 deoxygenase expression and activity. ... 05/25/06 - 20060110370 - Treatments for reduction of cytotoxicity and viral contamination of implantable medical devices A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective to render the biomaterial resistant to in vivo calcification upon implantation in a host animal. The anticalcification treatment solutions comprise higher alcohol solutions, a ... 05/25/06 - 20060110369 - Cell-filled device of modifield cross-section hollow fiber membrane type To provide a cell-filled device that is suitable for use in, for example, an implantable or circulation type hybrid artificial organ. In a cell-filled device including hollow fiber membranes whose hollow portions are filled with cells, the hollow fiber membranes have modified cross sections, and a cell aggregate provided in ... 05/25/06 - 20060110368 - Medium for culturing autologous human progenitor stem cells and applications thereof Described is a medium for the autologous culture of autologous human progenitor stem cells, which comprises: between 0.1 and 90 wt.-% autologous human serum; between 0.1 and 10,000 UI/ml heparin; between 0.1 and 10,000 UI/ml protamine; and a culture medium consisting of basic nutrients with or without glutamine, in a ... 05/18/06 - 20060104960 - Pharmaceuticals containing retinal stem cells The invention relates to stem cells isolated from the retina of mammals and retinal cells differentiated from these stem cells. The invention also relates to a method of isolating retinal stem cells and inducing retinal stem cells to produce retinal cells. Retinal stem cells may also be induced in vivo ... 05/18/06 - 20060104959 - Cell lines The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302. ... 05/18/06 - 20060104958 - Tissue engineered cardiac constructs Tissue-engineered bio-active cardiac constructs (BACCS) are described. These constructs are prepared by combining a suspension of isolated cells with a suitable support such as an extra-cellular filament or matrix. The isolated-cell component of the constructs is prepared from mammalian cardiac tissue, or from cells that differentiate into cardiac tissue. Extra-cellular ... 05/18/06 - 20060104957 - Bioartificial lacrimal gland The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the housing interior to the housing exterior; and (c) a population of lacrimal epithelial cells within the housing interior. ... 05/11/06 - 20060099192 - Method for generating an expandable tissue culture from progenitor cells and tissue so generated This invention relates to neuronal tissue which is suitable to restore neuronal deficits following transplantation. To reduce immunological side effects and to increase the microbiological and genetic safety of the tissue we propose tissue that does not contain glial cells and is maintained in vitro for prolonged periods. The method ... 05/11/06 - 20060099191 - Cell-seeded tissue-engineered polymers for treatment of intracranial aneurysms Methods and materials for treating intracranial aneurysms with a tissue-engineered biopolymer are disclosed. A novel technique has been developed which utilizes a tissue-engineering biopolymer (TEBP) with living endothelial cells such that the endothelial cells will produce a neoendothelium across the aneurysm ostium. Alternatively, biocompatible materials can be coated onto aneurysm ... 05/11/06 - 20060099190 - Method for transdifferentiating mesenchymal stem cells into neuronal cells This inventive discloses a method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor in the mesenchymal stem cells, said cells being useful in cell therapy or gene therapy for treating brain neurological diseases such as Parkinson's disease, Alzheimer ... 05/04/06 - 20060093588 - Device for bio-affinity material Bio-affinity material containing at least one biologically active saccharide which is covalently bound via at least one spacer to a cross-linked matrix and that the material is autoclaved. Apparatus for contacting body fluids with the bio-affinity material is disclosed. ... 05/04/06 - 20060093587 - Transplants for myocardial scars A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart. ... 05/04/06 - 20060093586 - Generation and differentiation of adult stem cell lines The present invention teaches a new method of stem cell generation involving the establishment of a mesenchymal cell culture, induction of epithelial marker expression and isolation and cloning of the cells expressing epithelial markers and expansion of these cell lines. Further processes are described for a two-step method to induce ... 04/27/06 - 20060088510 - Targeted delivery of biological factors using self-assembling peptide nanofibers The present invention is directed to methodology that allows a variety of compounds to be attached to self-assembling peptides using biotin/streptavidin linkages. The peptides can be used to form a biologically compatible membrane that promotes the growth and differentiation of cells. The attached therapeutic agents can be used to promote ... 04/27/06 - 20060088509 - Isolated clk-1 -/- cells from clk-1 heterozygous animals and their use in treating oxidative stress disorders The invention relates to the field of oxidative stress disorder and more specifically to isolated cells from clk-1 +/− animals that do not express CLK1. The invention also relates to methods for treating a subject or a diseased tissue in need of treatment for oxidative stress disorder using isolated clk-1 ... 04/27/06 - 20060088508 - Method for obtaining characterized muscle-derived cell populations and uses A method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products includes culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of ... 04/27/06 - 20060088507 - Rhodamine derivatives for photodynamic diagnosis and treatment The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of ... 04/27/06 - 20060088506 - Process for producing cartilage cells for transplantation This invention is intended to provide a method to quickly obtain a large amount of normal human chondrocytes or a mass thereof without fear of bacterial or viral infection. Namely, a method of producing human chondrocytes characterized by comprising co-culturing chondrocytes obtained from a cartilage having perichondrium, for example, auricular ... 04/27/06 - 20060088505 - Hair follicle mesenchymal stem cells and use thereof The present invention relates to a method for isolating hair follicle mesenchymal stem cells and to the use thereof for therapy and prophylaxis as well as for cosmetic treatments. ... 04/20/06 - 20060083721 - Injectable cross-linked polymeric preparations and uses thereof A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic ... 04/20/06 - 20060083720 - Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions Adipose derived regenerative cells are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells, e.g., stem and/or progenitor cells, obtained from the adipose tissue to a patient. The methods may be ... 04/20/06 - 20060083719 - Fixed-dried red blood cells Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by ... 04/06/06 - 20060073122 - Method for activating human antigen presenting cells, activated human antigen - presenting cells, and use thereof The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts thereof [preferred example: (2S,3S,4R)-1-(α-D-galactopyranosyloxy)-2-hexacosanoylamino-3,4-octadecanediol], and to human antigen-presenting cells activated by the method. The invention also relates to a method for ... 03/30/06 - 20060067918 - Cell lines The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302. ... 03/30/06 - 20060067917 - Insulin delivery system Aspects of the disclosure generally relate to insulin delivery systems and compositions having a insulin secreting β cell line or insulin secreting recombinant non-β cells sequestered in a glucose-responsive material. The disclosed insulin delivery systems can be surgically implanted in a host and can provide a continuous source of insulin ... 03/30/06 - 20060067916 - Sperm cell process system A semen or sperm cell process system to maintain or enhance the biological, chemical, physical, physiological, or functional attributes of sperm cells within the context of various collecting, handling, storage, transportation, separation, or insemination procedures. ... 03/23/06 - 20060062771 - Therapeutic autologous-cell delivery support system, financial system for use therewith, and method therefor Disclosed is a therapeutic autologous-cell delivery support system 100, in which a therapeutic autologous cell extracted from a member is reserved in reserve means 34, and an autologous-cell delivery request from the member which includes ID information and positional information is received. Membership information is retrieved in accordance with the ... 03/23/06 - 20060062770 - Organogenesis from dissociated cells A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method ... 03/23/06 - 20060062769 - Method of pre-inducing a state of immune tolerance before organ transplantation Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker ... 03/23/06 - 20060062768 - Biocompatible hydrogel compositions Compositions, instruments, systems, and methods are providing for creating families of materials having diverse therapeutic indications and possessing enhanced biocompatibility. The genus platform for the families includes a biocompatible synthetic electrophilic component mixed with a nucleophilic component. The electrophilic component can include a functionalized electrophilic poly (anhydride ester) material. The ... 03/23/06 - 20060062767 - Method of intervertebral disc treatment using articular chondrocyte cells Harvesting articular chondrocyte cells from a non-critical location of a patient and growing additional cells for transplantation into a damaged or diseased disc of the patient. ... 03/23/06 - 20060062766 - Remedy for cancer The present invention is directed to a therapeutic drug for cancer, containing, as an active ingredient, dendritic cells stimulated with an antigen derived from vascular endothelial cells which have been cultured in a medium containing a cancer cell culture supernatant. ... 03/16/06 - 20060057126 - Device and method for hair growth from stem cells A method for utilizing an individual's undifferentiated papilla and/or bulge area stem cells to stimulate hair growth. The inventor has discovered that bulge area stem cells can be harvested, isolated, cloned, and successfully transplanted into an area of the donor's skin where increased growth of hair is desired to increase ... 03/16/06 - 20060057125 - Liver stromal cells for prevention and treatment of immune responses in transplantation The present invention encompasses methods and compositions for reducing an immune response to a transplant in a recipient by treating said recipient with an amount of liver stromal cells effective to reduce or inhibit host rejection of the transplant. Also disclosed is a method of inducing a reduced immune response ... 03/16/06 - 20060057124 - Methods and compositions for culturing cardiomyocyte-like cells The present invention provides cardiomyocyte-like cells that have been cultured from populations of bone marrow cells. The culture method includes the use of defined media that are free of agents such a 5-azacytidine. The cardiomyocyte-like cells can be engrafted to heart tissue to repair damage resulting from an ischaemic episode. ... 03/16/06 - 20060057123 - Method of inducing memory b cell development and terminal differentiation A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B ... 03/16/06 - 20060057122 - Functional assessment, specific enrichment and specific depletion of alloreactive human t cells Alloreactive immune cell populations, clinical uses thereof and a means for specifically depleting alloreactive immune cells, while sparing other immune cell populations and thereby retaining broad specificity for other immune stimuli are disclosed. The present disclosure relates a means for specifically depleting alloreactive T cells, while sparing other T cell ... 03/16/06 - 20060057121 - Compositions and treatments using ex vivo activated cells for myelosuppressed patients The disclosure includes protocols for activating and administering human blood cells to severely myelosuppressed patients, including patients treated for cancer, e.g., by chemotherapy or radiation. The protocol may include culturing blood cells in the presence of activating agents, for example, a cytokine and an ionophore. ... 03/16/06 - 20060057120 - Administration of dendritic cells partially matured in vitro for the treatment of tumors The present invention provides populations of cells comprising partially matured dendritic cells that can be used for administration individuals having a tumor. Partially matured dendritic cells, those contacted with a dendritic cell maturation agent for about 1 to about 10 hours, or more, efficiently take up and process tumor antigens ... 03/16/06 - 20060057119 - Biologic skin repair and enhancement Muscle cell materials and methods are provided for refurbishing skin. Skin surfaces are prepared by removing dead cells and myoblasts are added in a cell-nutritive solution. An embodiment provides autologous human myoblast cells from the individual to be treated, serum from the individual, and an angiogenesis factor for stimulation of ... 03/09/06 - 20060051329 - Microfluidic device for the encapsulation of cells with low and high cell densities Devices and methods for the encapsulation of cells on microfluidic platforms are disclosed. The microfluidic device generally includes a plurality of functional regions to shear, focus, and encapsulate a desired cell or group of cells into a droplet. The microfluidic device can further comprise a polymerization zone to form a ... 03/09/06 - 20060051328 - Mobilization of cells via physical means A method for treating a patient to repair or regenerate damaged tissue which comprises exposing the patient to an internal physical treatment of the body, for example ultrasound waves or ultra shock waves, MRI or bone surgery so that stem cells, progenitor cells and/or macrophages are released into the bloodstream ... 03/09/06 - 20060051327 - Use of synovium and omentum for tissue engineering A method for treating a patient to repair or regenerate damaged tissues or organs in which synovium from a joint or omentum from the abdomen are harvested to provide explants, optionally separating cells from the synovium or omentum explants for culture or tissue specification, and introducting the explants or separated ... 03/09/06 - 20060051326 - Neural transplantation using pluripotent neuroepithelial cells The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are ... 03/09/06 - 20060051325 - Isolation and use of solid tumor stem cells A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give ... 03/09/06 - 20060051324 - Pharmaceutical composition for inducing an immune response in a human or animal The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and no lineage specific differentiation antigens or substantially no lineage specific differentiation antigens provided from at least one cancer cell line, as ... 03/02/06 - 20060045872 - Use of adipose tissue-derived stromal stem cells in treating fistula Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae. ... 02/23/06 - 20060039896 - Augmentation and repair of age-related soft tissue defects The present invention discloses methods for the long-term augmentation and/or repair of skin defects (scars, skin laxness, skin thinning, and skin augmentation), cellulite, breast tissue, wounds and burns, urological and gastroesophageal sphincter structures, hernias, periodontal disease and disorders, tendon and ligament tears and baldness, by the injection or direct surgical ... 02/23/06 - 20060039895 - Ex-vivo rescue of hematopoietic stem cells after lethal irradiation A method of autologous rescue of an individual exposed to a harmful hematopoietic stem cell condition is described. The method includes removing hematopoietic stem cells from the individual, culturing the hematopoietic stem cells and reintroducing cultured hematopoietic stem cells into the individual. Stem cells are grown in a stromal-cell free ... 02/16/06 - 20060034809 - Dry platelet preparation containing stabilized platelets and platelet microparticles as tissue regenerative and non-infusible hemostat The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a hemostat, such as for treating bleeding or injuries associated with bleeding. It also provides methods of treating injuries or wounds, and methods of causing blood to clot. Likewise, it provides methods of promoting healing of ... 02/16/06 - 20060034808 - Amorphous cell delivery vehicle treated with physical/physicochemical stimuli Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular ... 02/16/06 - 20060034807 - Innervated artificial tissues and uses thereof A three dimensional, innervated artificial tissue comprising a bio-synthetic matrix is provided. The artificial tissue supports cell growth, including surface coverage and three-dimensional cell in-growth, as well as nerve in-growth. Methods of preparing the innervated artificial tissue and methods of innervating artificial tissues or tissue substitutes are also provided. The ... 02/09/06 - 20060029581 - Human growth hormone to stimulate mobilization of pluripotent hematopoietic stem cells The invention relates to the field of hematopoietic CD34+ cell mobilization. In particular, this invention relates to a method for increasing the mobilization of pluripotent hematopoietic CD34+ cells by administration of human growth hormone or one of its derivates to the individual. ... 02/09/06 - 20060029580 - Method for treating a condition with neural progenitor cells derived from whole bone marrow A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). Further methods of the present invention are directed to ... 02/09/06 - 20060029579 - Methods and compositions for producing target cell reactive lymphocytes in a subject Methods and compositions for producing target cell reactive lymphocytes, e.g., cytolytic T-lymphocytes, in a subject are provided. In practicing the subject methods, a lymphocyte population is contacted with an effective amount of a target cell peptide mixture of active and inactive peptides to produce lymphocytes reactive, e.g., cytolytic, for the ... 02/09/06 - 20060029578 - Composition and method for the repair and regeneration of cartilage and other tissues The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere ... 02/02/06 - 20060024277 - Method of skin care and/or treatment using extracts enriched in mitochondria Methods for the prevention and treatment of skin aging arising from depletion of components of the mitochondrial membranes or the respiratory system using extracts rich in mitochondrial components in a dermatologically acceptable carrier that can be topically applied to the skin areas, including lips. In some embodiments, proteins such as ... 02/02/06 - 20060024276 - Hybrid device for cell therapies A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an ... 02/02/06 - 20060024275 - Methods for use of mpl ligands with primitive human stem cells Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin supports both megakaryocytic differentiation and primitive progenitor cell expansion of CD34+ and CD34+ sub-populations (CD34+Lin−, CD34+Thy-1+Lin−, and ... 01/26/06 - 20060018887 - Enhanced adipose tissue An enhanced adipose tissue containing native adipose tissue and a concentrated amount of an active agent derived from adipose tissue, wherein the enhanced adipose tissue is preferably injected into the intervertebral disc of a patient suffering from degenerative disc disease. ... 01/26/06 - 20060018886 - Modalities for the treatment of degenerative diseases of the retina This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. ... 01/26/06 - 20060018885 - Methods for increasing hsc graft efficiency This invention demonstrates that FC function via TNF-α to affect function of HSC. FC from TNF-α deficient mice are impaired in facilitating HSC engraftment in both the syngeneic and allogeneic models. Co-incubation of FC with HSC results in significant increase in TNF-α at the mRNA and protein level, and increase ... 01/19/06 - 20060013804 - Modulation of stem cell differentiation by modulation of caspase-3 activity Methods of directing stem cell fate for therapeutic purposes through the deliberate manipulation of caspase-3 activity are provided. The use of modulators of caspase-3 activity to modulate stem cell differentiation is described including activators and/or effectors of caspase-3, which can be used to induce stem cell differentiation, and inhibitors of ... 01/05/06 - 20060002903 - Anti-inflammatory conformal barriers for cell transplantation The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells with conformal barriers. The coatings comprise polymer layers deposited on a cell surface by layer-by-layer polymer assembly, wherein each layer contains a positive and ... 01/05/06 - 20060002902 - System for providing implant compatibility with recipient A system for providing or enhancing compatibility between an implant and a recipient. The system includes a recipient, typically a living biological organism, that further includes a target region; an implant having a first attraction means; and a plurality of cells. The cells are compatible with the target region and ... 01/05/06 - 20060002901 - Composition containing eosinophil cationic protein A therapeutic composition for a disease caused by a failure in the survival, proliferation and/or differentiation of a cell which contains eosinophil cationic protein and other components; and a medium composition for promoting the survival, proliferation and/or differentiation of a cell. ... 01/05/06 - 20060002900 - Retinal pigment epithelial cell cultures on amniotic membrane and transplantation The present invention relates to a composition for implantation in the subretinal space of an eye, the composition including amniotic membrane, which may be cryopreserved human amniotic membrane, and a plurality of retinal pigment epithelial (RPE) cells or RPE equivalent cells present at the amniotic membrane. The amniotic membrane may ... 01/05/06 - 20060002899 - Generation of dendritic cells from cd34+precursors The present invention relates to a method for inducing development of dendritic cells from CD34+ precursor cells. More particularly, the present invention relates to a method of differentiating CD34+ precursor cells into myeloid- and or lymphoid-dendritic cells. The present invention provides a protocol for the development of dendritic cells from ... 01/05/06 - 20060002898 - Methods and compositions for correction of cardiac conduction disturbances The invention provides methods for establishing electrical coupling between cardionyocytes and recombinant cells which have been genetically engineered to express a gap junction protein, eg., Connexin protein such as Connexin 43 (CX43) protein, n invention is based on the discovery that genetic modification of skeletal muscle cells to express a ... 12/29/05 - 20050287126 - Ectocornea-like sheet and method of constructing the same It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial ... 12/29/05 - 20050287125 - Cell delivery fluid for prevention of cell settling in delivery system A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific ... 12/29/05 - 20050287124 - Method for inducing bone marrow-derived cells in injured epithelial site and a method for repairing injured epithelium It is an object of the present invention to provide a method for repairing injured epithelial cells, impossibility of the repair of which results in fatal consequences. The present invention provides a method for inducing bone marrow-derived cells into the injured epithelial site of a patient and a method for ... 12/22/05 - 20050281790 - Mesenchymal precursor cell A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of ... 12/22/05 - 20050281789 - Transcutaneous and/or transdermal transport of materials The invention relates to transcutaneous and/or transdermal transport of materials, such as antigens, drugs, drugs, nucleic acids, (e.g., DNA and RNA), proteins, other therapeutic agents, dyes, and the like, into the skin and/or the body. The material is transported transcutaneously and/or transdermally using an antigen presenting cell (APC) by applying ... 12/22/05 - 20050281788 - Compositions comprising muscle progenitor cells and uses thereof The present invention shows in vivo myogenic differentiation of muscle progenitor cells (MPCs), being derived from joint tissue, in a mouse model of skeletal muscle regeneration. MPCs participated in the regeneration process by long-term persistence and contribution to the compartment of myonuclei and the pool of functional satellite cells. When ... 12/15/05 - 20050276794 - Composition and method for improving pancreatic islet cell survival The invention provides a composition for protecting islet cells during isolation and transplantation, as well as a method for increasing survival of islets and islet cells during harvest from the donor pancreas, isolation and culture, transportation, and transplantation into the recipient. The composition provides at least one Vitamin E homolog ... 12/15/05 - 20050276793 - Methods for in vitro expansion of hematopoietic stem cells The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells ... 12/15/05 - 20050276792 - Systems and methods for providing a stem cell bank Methods, computer systems, and computer program products for maintaining a stem cell registry comprising information about a plurality of stem cell units. A donor is enrolled in the stem cell registry. A stem cell unit from the donor is characterized. Information about the stem cell unit, obtained by the characterizing, ... 12/15/05 - 20050276791 - Multi-layer polymer scaffolds Three-dimensional single or multilayer polymer scaffolds for use in tissue engineering and other applications are provided. These scaffolds typically include at least two layers of biodegradable polymer of similar thickness, wherein each layer of polymer further includes a plurality of substantially uniform structural features having predetermined geometries, and wherein each ... 12/08/05 - 20050271635 - In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a ... 12/08/05 - 20050271634 - Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA, VEGFB, PLGF, VEGF121, VEGF145, VEGF165, VEGF189, and VEGF206; (ii) isolating the ... 12/08/05 - 20050271633 - Issue defect augmentation and repair with in vitro cultured fibroblasts Certain embodiments herein are directed to a method of treating a tissue associated with a defect in a human including wrinkles, rhytids, depressed scar, cutaneous depressions, stretch marks, hyperplasia of the lip, nasolabial fold, melolabial fold, scarring from acne vulgaris, and post-rhinoplasty irregularity. The tissue defect may be treated by ... 12/08/05 - 20050271632 - Methods of modulating hair growth The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. ... 12/08/05 - 20050271631 - Material compositions and related systems and methods for treating cardiac conditions A medical condition associated with a cardiac structure is treated by injecting an injectable polymer agent into the cardiac structure such that a therapeutic mechanical scaffolding is formed within the cardiac structure itself. In particular, the injectable scaffolding agent is a fibrin glue agent and is injected into regions of ... 12/08/05 - 20050271630 - Method for treating cancer A method for treating cancer having fewer side effects than conventional therapies and capable of improving a response ratio by combining a molecular targeting agent and an immuno-cell therapy. ... 12/01/05 - 20050265982 - Epidermal melanocyte culture formulations The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of epidermal melanocytes that exhibit growth, ... 12/01/05 - 20050265981 - Transdifferentiation of glial cells A process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate fetal or adult mammalian glial cells into multipotent cells. The multipotent cells may further be differentiated into particular types of nervous system cells, including neurons, astrocytes, and oligodendrocytes. A small sample of astrocytes is used ... 12/01/05 - 20050265980 - Cell culture environments for the serum-free expansion of mesenchymal stem cells Compositions and methods for promoting mesenchymal stem cell expansion while maintaining a pluripotent phenotype are disclosed. Serum-free cell culture systems and kits and methods of use for mesenchymal stem cell expansion are provided. Methods also comprise the use of the expanded mesenchymal stem cells to treat various disorders or diseases, ... 12/01/05 - 20050265979 - Method for cryopreserving microencapsulated living animal cells enclosed in immunoisolation membranes, such microencapsulated living animal cells in immunoisolation membranes, and biohybrid artificial organ modules using such microencapsulated living anim A method is disclosed for cryopreserving living animal cells in immunoisolation membranes, including: (1) cutting out a living organ from an animal, (2) digesting the cutout organ into the discrete living animal cells and separating the discrete cells, (3) suspending the separated cells in a solution of sodium chloride containing ... 12/01/05 - 20050265978 - Muscle-derived cells (mdcs) for treating muscle- or bone-related injury or dysfunction The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional segments of such genes, for delivery of the encoded gene products at or near sites of musculoskeletal, bone, ligament, meniscus, cartilage or genitourinary disease, injury, ... 12/01/05 - 20050265977 - Xenotransplant for cns therapy Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal. ... 12/01/05 - 20050265976 - Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired ... 11/24/05 - 20050260177 - Compounds for immunotherapy and diagnosis of colon cancer and methods for their use Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, ... 11/24/05 - 20050260176 - Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices. ... 11/24/05 - 20050260175 - Systems and methods for isolating and using clinically safe adipose derived regenerative cells Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating ... 11/24/05 - 20050260174 - Systems and methods for treating patients with processed lipoaspirate cells Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are ... 11/24/05 - 20050260173 - Arrrangement for using bioactive or osteoinductive material to build up a bone-based lateral support for implants in the jaw bone With the aid of bioactive or osteoinductive substances (10), a bone-based lateral support is built up for an implant (6) arranged in an assigned jaw bone hole in jaw bone (2) which extends defectively or irregularly. The implant is arranged so that it can be completely or partially covered by ... 11/24/05 - 20050260172 - Culture of goblet cells The invention encompasses isolation, culture and characterization of goblet cells in vitro form mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure ... 11/17/05 - 20050255091 - Hydrogels for biomedical applications The invention relates to methods for the formation of hydrogels by the intensive mixing of aqueous compositions containing copolymers of opposite chirality. Such hydrogels may he bioresorbable and are useful for medical applications within mammalian bodies. ... 11/10/05 - 20050249710 - Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer. ... 11/10/05 - 20050249709 - Bone substitute A bone substitute which consists of a porous metallic or a biocompatible, open-cell material which is wholly or partly impregnated with a solution comprising factor XIII, or at least some of its pores are filled with a solution comprising factor XIII, is described. ... 11/10/05 - 20050249708 - Cerebral intraventricular transplantation as method of treating amyotrophic lateral sclerosis (als) A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH+) expressing progenitor cells provides cell replacement and protection of motor neurons. ... 11/03/05 - 20050244387 - Entomopathogenic nematodes and methods of their use An isolated nematode, wherein the nematode is Heterorhabditis bacteriophora strain GPS11, which was deposited at the ATCC, 10801 University Blvd., Manassas, Va. 20110-2209, on Apr. 22, 2004, under accession number ______. Methods of use of this nematode are also described. ... 11/03/05 - 20050244386 - Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker ... 11/03/05 - 20050244385 - Intradermal cellular delivery using narrow gauge micro-cannula A method for delivering cells into a subject by administering cells into the intradermal space of the skin of the subject by a microneedle. The cells are associated with cellular based therapeutics and vaccines and delivered by perpendicular insertion of the microneedle. The microneedle is a hollow needle having an ... 11/03/05 - 20050244384 - Cellular transplantation for heart regeneration Myoblast cells obtained by culturing, particularly from satellite cells or other progenitor cells, are transplanted into tissue such as diseased heart tissue to form healthy repair tissue and reverse disease. This technique can be carried out in various ways and preferably includes a cellular integration factor to assist cellular survival, ... 10/27/05 - 20050238623 - Method for treating mammals with modified mammalian blood An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either ... 10/20/05 - 20050232903 - Method for producing human intervertebral disc cells There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a growth factor, or a cytokine or a bioactive agent to form monolayer primary cell cultures on ... 10/20/05 - 20050232902 - Injectable bioartificial tissue matrix The present invention encompasses a liquid bioartificial tissue for restoring tissue and organ function to an injured or damaged organ in a human subject. The liquid bioartificial tissue is injected into a target organ and can significantly restore organ function within two weeks. The invention also encompasses a cell culture ... 10/13/05 - 20050226857 - T cell therapy for the treatment of cachexia and chronic diseases The present invention relates to compositions and methods for the use of T cells and more particularly, activated T cells, in the treatment and/or amelioration of diseases associated with a proinflammatory state, such as cachexia, chronic diseases such as chronic renal failure, and hepatitis. ... 10/13/05 - 20050226856 - Autogenic living scaffolds and living tissue matrices: methods and uses thereof A 3-dimensional structure comprising suitable cells (or entities) and the ECM (or matrix) that has been completely produced and arranged by these cells (or entities) that promotes the differentiation, dedifferentiation and/or transdifferentiation of cells and/or formation of tissue in vitro and in vivo, while at the same time promoting cell ... 10/13/05 - 20050226855 - Method and instrumentation for control of stem cell injection into the body A method is described for repairing tissue of a selected organ from among heart, brain, liver, pancreas, kidney, and glands in a patient's body. In the method, stem cells that have the capability to repair tissue of the selected organ are intraluminally applied through a designated natural body vessel or ... 10/13/05 - 20050226854 - Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage. ... 10/13/05 - 20050226853 - Skin substitutes and uses thereof The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior to seeding with keratinocytes. In other embodiments, increased concentrations ... 10/13/05 - 20050226852 - Method of inducing growth of nerve stem cells It is intended to provide a method of efficiently inducing the growth of nerve stem cells, which are most important in transplantation therapy for nerve damage and neurological dysfunction, either in vitro or in vivo, a method of using the nerve stem cells obtained by the above growth induction method, ... 10/06/05 - 20050220771 - Methods of performing medical procedures that promote bone growth, methods of making compositions that promote bone growth, and apparatus for use in such methods Methods of performing medical procedures, and methods of making bone-growth-promoting compositions useful in performing medical procedures are provided. Apparatus useful both in methods of performing medical procedures, and in methods of making bone-growth-promoting compositions useful in performing medical procedures, are provided. The bone-growth-promoting compositions made according to the disclosed methods ... 09/29/05 - 20050214262 - Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for ... 09/29/05 - 20050214261 - Method for treating a skin defect A cell-containing artificial dermis is produced by a method comprising the steps of defrosting endothelial cells and fibroblasts preserved in a frozen state, impregnating a collagen sponge with PDWHF, and dispersing the endothelial cells and fibroblasts on the collage sponge to form an artificial dermis. The invention also provides a ... 09/29/05 - 20050214260 - Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease Acute and chronic heart disease is treated using a rational, multi-tier approach. A patient is pretreated with growth factor proteins or gene therapy, followed by the administration of adult stem cells. The progress of treatment is continuously monitored by echo-cardiogram with growth factor treatment and/or stem cell administration adjusted according ... 09/29/05 - 20050214259 - Corneal endothelium-like sheet and method of constructing the same It is our intention to provide a transplantation material applicable to the treatment of various diseases that require corneal endothelium transplantation. Corneal endothelial cells are collected, proliferated and then sown on amnion and cultured. Thus, a corneal endothelium-like sheet, which has a cell layer made up of the corneal endothelium-origin ... 09/22/05 - 20050208028 - Nutrient medium for maintaining neural cells in injured nervous system A method to improve neural cell viability in brain or spinal cord tissue after brain or spinal cord injury or surgery is provided. This method comprises applying a sterile liquid medium to the brain or spinal cord tissue, wherein the sterile aqueous liquid medium comprises 0 to about 3000 μM ... 09/22/05 - 20050208027 - Methods and compositions for regeneration of aged tissues The regenerative potential of aged stem cells is enhanced by activation of the Notch signaling pathway and/or inhibition of TGF-β signaling pathway. Stem cells in aged tissues are capable of proliferation and tissue regeneration, but in their native setting are not provided with the appropriate signals to do so. By ... 09/22/05 - 20050208026 - Tissue engineered uterus The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These ... 09/22/05 - 20050208025 - Enhancement of hematopoietic stem cell survival A composition is disclosed that includes lin− cells that are characterized as expressing CD31, CD34 and CD105, and not expressing c-kit, wherein the composition comprises fewer than 20% of lineage committed cells. Methods are disclosed for isolating CD31+CD34+CD45−CD105+c-kit− cells. Methods for reconstituting hematopoiesis using compositions including CD31+CD34+CD105+CD45−kit− cells are also ... 09/15/05 - 20050201990 - Endothelial progenitor cells and methods of use thereof Endothelial progenitor cells immunoreactive for VEGFR-2 or Tie-2, and CD45 are provided. Optionally the cell is immunoreactive with CD14. The cells are capable of differentiating in vivo into an endothelial cell or a smooth muscle cells. The cultures integrate well after transplantation into adult vasculature. ... 09/15/05 - 20050201989 - Compositions and methods for ex vivo preservation of blood vessels for vascular grafts using inhibitors of tumor necrosis factor-alpha The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts by inhibiting TNF-α. The present invention also relates to compositions comprising an inhibitor of a TNF-α for use in the methods of the invention, which compositions are free of active ... 09/15/05 - 20050201988 - Universal red blood cells, methods of preparing same, and uses thereof The present invention is directed to pegylated red blood cells comprising a polyethylene glycol (PEG) attached to a thiolated amino group on a membrane protein, and to compositions comprising the pegylated red blood cells. The invention also provides methods of preparing pegylated red blood cells comprising reacting red blood cells ... 09/15/05 - 20050201987 - Bone grafting material, method and implant A bone grafting material, a method of producing the same, and an implant. The bone grafting material comprises a porous carrier of ceramic or glass ceramic or glass material and at least one pyrrolidone arranged in the carrier. ... 09/08/05 - 20050196387 - Intervertebral disk repair, methods and devices therefor The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise ... 09/08/05 - 20050196386 - Regulatory t cells and their use in immunotherapy and suppression of autoimmune responses Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and culture-expanded isolated CD4+CD25+ suppressor Treg cells for the prevention or suppression of immune reactions in a host, particularly in ... 09/08/05 - 20050196385 - Methods for producing gamma delta t cells The invention concerns methods for producing lymphocytic cells, as well as tools, reagents and kits useful for implementing same. More particularly, it concerns methods for preparing gamma delta T cells, adapted to industrial production of functional cells of pharmaceutical quality in large amounts. The invention also concerns methods for activating ... 09/01/05 - 20050191282 - Method of cryopreserving pancreatic islet cells Isolated pancreatic islet cells are cultured and then cyropreserved in a polyvinyl pyrrolidone medium. ... 09/01/05 - 20050191281 - Tissue graft The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue. ... 09/01/05 - 20050191280 - Immune regulation A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject. ... 08/25/05 - 20050186183 - Stabilized products, processes and devices for preparing same Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological ... 08/25/05 - 20050186182 - Methods of using g-csf mobilized c-kit+ cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy The present invention relates to methods of using granulocyte colony stimulating factor (G-CSF) polypeptide, alone and in conjunction with stromal cell derived factor (SDF-1) polypeptide, to increase the mobilization of c-Kit+ stem cells in the blood, bone marrow, tissue, heart or other organs for the subsequent production of embryoid body-like ... 08/18/05 - 20050180958 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells A method of transplanting undifferentiated hemopoietic stem cells into a recipient is provided. The method comprising the steps of: (a) expanding/maintaining the undifferentiated hemopoietic stem cells by: (i) obtaining the undifferentiated hemopoietic stem cells; and (ii) culturing the undifferentiated hemopoietic stem cells in a medium containing a stromal cell conditioned ... 08/18/05 - 20050180957 - Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material with a growth factor and conjugate into a patient in need of treatment. Several methods are presented to accomplish transplanting several different types of biological materials. This invention also provides ... 08/18/05 - 20050180956 - Ssao enzyme substrates for vasorelaxation, and methods of use thereof Another embodiment relates to a method of processing a blood vessel comprising preparing a blood vessel for implantation in a patient and exposing the blood vessel to a physiological solution that comprises an exogenous substrate for an SSAO enzyme. Another embodiment is a composition having a concentration of an exogenous ... 08/11/05 - 20050175595 - Method for reinstalling control system for antigenic homeostasis of mammalian organisms (effect of kukharchuk-radchenko-sirman) The invention relates to a novel method for induction of immunological tolerance in a mammal with embryonic pluripotent progenitor cells (EPPC) via the formation of a new basis of immunocompetent cells with simultaneous de novo installation of the control system for the antigenic homeostasis (Kukharchuk-Radchenko-Sirman effect). This method can be ... 08/04/05 - 20050169896 - Bone marrow transplantation for treatment of stroke The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of stromal cells for the treatment of neural injury (stroke, traumatic brain injury, spinal cord injury) and neurodegeneration (i.e. Parkinson's disease). ... 08/04/05 - 20050169895 - Use of alginate matrices to control cell growth Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal's body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal's body are disclosed. Devices that have on their exterior surface ... 08/04/05 - 20050169894 - Compositions and methods for ex vivo preservation of blood vessels for vascular grafts using inhibitors of type iii and/or type iv phosphodiesterases The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts by specifically inhibiting Type III and/or Type IV phosphodiesterases. The present invention also relates to compositions comprising a specific inhibitor of a Type III and/or Type IV phosphodiesterase for use ... 08/04/05 - 20050169893 - Bone restorative carrier mediums Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities. ... 07/28/05 - 20050163759 - Compositions and methods for ex vivo preservation of blood vessels for vascular grafts using inhibitors of type i and/or type ii phosphodiesterases The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts by specifically inhibiting Type I and/or Type II phosphodiesterases. The present invention also relates to compositions comprising a specific inhibitor of a Type I and/or Type II phosphodiesterase for use ... 07/21/05 - 20050158287 - Methods for using the obese gene and its gene product to identify hematopoietic progenitor cells The present invention relates to methods for using various forms of a novel receptor expressed by hematopoietic and endothelial cells. An additional variant form of this receptor has been detected in brain cells and shown to bind to the obese gene product, leptin. Therefore, leptin may be used to stimulate ... 07/21/05 - 20050158286 - Differentiation of specialized dermal and epidermal cells into neuronal cells Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting of keritinocytes and/or melanocytes; taking a sample of tissue from the surface area; mechanically disaggregating the tissue ... 07/21/05 - 20050158285 - Method of re-profiling adult stem cells using embryonic stem cell electromagnetic signals Methods of re-profiling adult stem cells are disclosed, which include recording electromagnetic signals from an embryonic stem cell, cytoplasm thereof, individual components of the cytoplasm, nucleus thereof, or chromosome from the nucleus, using an electronic device and storing the electromagnetic signals; and then transmitting the electromagnetic signals to the adult ... 07/21/05 - 20050158284 - Method for treating, preventing, or inhibiting enterotoxigenic escherichia coli infections with bovine red blood cells Disclosed herein are red blood cell (RBC) preparations and methods of making and using thereof for treating, preventing or inhibiting enterotoxigenic Escherichia coli (ETEC) infections. In particular, bovine RBC preparations are shown to reduce ETEC adhesion when administered orally. Also disclosed are kits comprising RBC preparations for the treatment of ... 07/14/05 - 20050152883 - Compositions and methods for ligament growth and repair The present invention provides methods and compositions for treating and repairing ligament defects using a bone morphogenic protein. The present invention provides methods of treating ligament defects, repairing ligament defects, forming ligament tissue, regenerating ligament tissue, and promoting growth of ligament tissue by transplanting into a patient in need thereof ... 07/14/05 - 20050152882 - Particulate cartilage system The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions. ... 07/14/05 - 20050152881 - Muscle-based grafts/implants The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for ... 07/14/05 - 20050152880 - Matrix composition for human grafts/implants The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the ... 07/07/05 - 20050147597 - Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells ... 07/07/05 - 20050147596 - Method of using autologous fibroblasts to promote healing of wounds and fistulas The present invention provides a method of using autologous fibroblasts to promote wound or fistula healing in an animal. ... 07/07/05 - 20050147595 - Bead embedded cells A composition of beads formed from biologically compatible material and which hold comprise biologically active moieties. A method of treating of treating isolated biological moieties in culture media, embedding the moieties in biologically compatible material which does not incorporate adventitious excipients. A method of treating individuals in need of transplantation, ... 07/07/05 - 20050147594 - Semi-permeable microcapsule with covalently linked layers and method for producing same The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increased resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalently linked to a semi-permeable layer, made of a polycation cross-linking ... 06/30/05 - 20050142119 - Human mesenchymal progenitor cell There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such cells. Specifically, there is provided isolated MPCs which can be used for diagnostic purposes, to enhance ... 06/30/05 - 20050142118 - Human cord blood derived unrestricted somatic stem cells (ussc) A composition in human cord and placental blood which comprises unrestricted somatic stem cells is described here which can be amplified in vitro to large quantities sufficient for medical applications as regenerative medicines. Initiation and maintenance as well as ex vivo expansion protocols of such stem cells from cord blood ... 06/30/05 - 20050142117 - Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tolerance inducing treatment regimen, used optionally with adjunct immunosuppressive agents, prevents pancreatic ... 06/23/05 - 20050136039 - Adipocytes and uses thereof The invention features methods of making and using subpopulations or subtypes of adipose cells based on their differential regulation of gene expression, size or function in response to modulation of insulin signaling. ... 06/23/05 - 20050136038 - Injectable calcium salt bone filler comprising cells The invention relates to a bone filler comprising calcium salt particles, an organic binder having an affinity for calcium phosphate, cells chosen from the group of stem cells, osteogenic cells, and osteoprogenitor cells, and a pharmaceutically acceptable buffer. A great advantage of a bone filler, according to the invention, is ... 06/16/05 - 20050129668 - Methods, instruments and materials for chondrocyte cell transplantation The present invention provides a method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. The present invention is also directed to an instrument for placing and manipulating the implantable article ... 06/16/05 - 20050129667 - High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such ... 06/16/05 - 20050129666 - Compositions comprising preconditioned myoblasts having enhanced fusion properties The present invention relates to a method for preconditioning healthy donor's myoblasts in vitro before transplantation thereof in compatible patients suffering of recessive myopathies, particularly of muscular dystrophy. This in vitro preconditioning improves the success of the transplantation while not requiring an in vivo preconditioning of the patient's muscle by ... 06/16/05 - 20050129665 - Isolated lineage negative hematopoietic stem cells and methods of treatment therewith Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lini HSCs express the cell surface antigen CD31. The ... 06/16/05 - 20050129664 - Remedy for dysmnesia Use of a culture of neural stem cells originating from embryonic stem cells in production of a remedy for dysmnesia. the present invention enables treatment of dysmnesia associated, for example, with Alzheimer's disease. ... 06/16/05 - 20050129663 - Process for the manufacturing of human mononuclear phagocytic leukocytes A process for the manufacture of human mononuclear phagocytic leukocytes comprises incubating monocytes isolated from a blood sample of an individual and skin segments from the same individual, removing the dermis segments from the incubation mixture and sedimenting the obtained activated mononuclear phagocytic leukocytes by centrifugation, washing and resuspending the ... 06/09/05 - 20050123520 - Generation of living tissue in vivo using a mold The invention features methods of making living tissue constructs having a predetermined shape by obtaining a negative mold having a defined shape; suspending isolated tissue precursor cells in a hydrogel to form a liquid hydrogel-precursor cell composition; filling the liquid hydrogel-precursor cell composition into the mold; implanting the filled mold ... 06/02/05 - 20050118147 - Method of using mesenchymal stromal cells to increase engraftment The present application discloses a composition that includes a sample of donor stem cells that are desired to be engrafted to a subject; and a sample of mesenchymal stromal cells. ... 06/02/05 - 20050118146 - In vitro synthesis of a layered cell sorted tissue The present invention relates to a layered cell sorted tissue that is formed in vitro. The tissue is generated by the spontaneous sorting of cells from a homogenous cell mixture into discrete layers by cell type. Connective tissue components, such as fibronectin, may be used to manipulate orientation of the ... 06/02/05 - 20050118145 - Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants The present invention relates to the use of Sertoli cells and myoid cells for creating an immunologically privileged site in a mammalian subject, thereby facilitating the transplantation of cells that produce a biological factor in the treatment of a disease that results from a deficiency of such biological factor. Pharmaceutical ... 06/02/05 - 20050118144 - Fibrin-based biomatrix The invention involves methods and materials related to fibrin-based biomatrices. ... 06/02/05 - 20050118143 - Isolated mammalian neural stem cells, methods of making such cells, and methods of using such cells Using a novel culture approach, previously unknown populations of neural progenitor cells have been found within an adult mammalian brain. By limiting cell-cell contact, dissociated adult brain yields at least two types of cell aggregates. These aggregates or clones of stem/precursor cells can be generated from adult brain tissue with ... 06/02/05 - 20050118142 - Cellular compositions which facilitate engraftment of hematopoietic stem cells while minimizing the risk of gvhd The present invention provides for cellular compositions which facilitate engraftment of hematopoietic stem cells from a syngeneic, allogeneic or xenogeneic donor. The cellular compositions of the invention facilitate engraftment while minimizing the risk of graft versus host disease in the graft recipient. According to a preferred embodiment of the invention, ... 06/02/05 - 20050118141 - Feline bronchioloalveolar lung carcinoma xenograft and cell line The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in experimental models of carcinoma in order to dissect out the molecular basis of this phenotype. This experimental model of carcinoma can be ... ### FreshPatents.com Support - Terms & Conditions |